centrioles

Summary

Summary: Self-replicating, short, fibrous, rod-shaped organelles. Each centriole is a short cylinder containing nine pairs of peripheral microtubules, arranged so as to form the wall of the cylinder.

Top Publications

  1. Villumsen B, Danielsen J, Povlsen L, Sylvestersen K, Merdes A, Beli P, et al. A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis. EMBO J. 2013;32:3029-40 pubmed publisher
  2. Peters N, Perez D, Song M, Liu Y, MULLER REICHERT T, Caron C, et al. Control of mitotic and meiotic centriole duplication by the Plk4-related kinase ZYG-1. J Cell Sci. 2010;123:795-805 pubmed publisher
    ..Meiotic centriole amplification appears to result from the overduplication of centrioles during meiosis I and leads to the formation of multipolar meiosis II spindles...
  3. Dammermann A, Maddox P, Desai A, Oegema K. SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. J Cell Biol. 2008;180:771-85 pubmed publisher
    b>Centrioles are surrounded by pericentriolar material (PCM), which is proposed to promote new centriole assembly by concentrating gamma-tubulin...
  4. Bahtz R, Seidler J, Arnold M, Haselmann Weiss U, Antony C, Lehmann W, et al. GCP6 is a substrate of Plk4 and required for centriole duplication. J Cell Sci. 2012;125:486-96 pubmed publisher
    ..We found that GCP6 is localized in the pericentriolar material but also at distal portions of centrioles. In addition, GCP6 is required for centriole duplication and Plk4-induced centriole overduplication...
  5. Hatch E, Kulukian A, Holland A, Cleveland D, Stearns T. Cep152 interacts with Plk4 and is required for centriole duplication. J Cell Biol. 2010;191:721-9 pubmed publisher
    b>Centrioles are microtubule-based structures that organize the centrosome and nucleate cilia...
  6. Song M, Liu Y, Anderson D, Jahng W, O Connell K. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011;20:563-71 pubmed publisher
    b>Centrioles play a crucial role in mitotic spindle assembly and duplicate precisely once per cell cycle...
  7. Mahen R, Venkitaraman A. Pattern formation in centrosome assembly. Curr Opin Cell Biol. 2012;24:14-23 pubmed publisher
    ..Centrosomes consist of two centrioles surrounded by a cloud of proteins termed the pericentriolar material (PCM)...
  8. Bornens M. The centrosome in cells and organisms. Science. 2012;335:422-6 pubmed publisher
    ..Here I will discuss the role of the centrosome in cell polarity, resulting from its ability to position the nucleus at the cell center, and discuss how centrosome innovation might have been critical during metazoan evolution...
  9. Vulprecht J, David A, Tibelius A, Castiel A, Konotop G, Liu F, et al. STIL is required for centriole duplication in human cells. J Cell Sci. 2012;125:1353-62 pubmed publisher
    b>Centrioles are key structural elements of centrosomes and primary cilia. In mammals, only a few proteins including PLK4, CPAP (CENPJ), SAS6, CEP192, CEP152 and CEP135 have thus far been identified to be required for centriole duplication...

More Information

Publications62

  1. Mottier Pavie V, Megraw T. Drosophila bld10 is a centriolar protein that regulates centriole, basal body, and motile cilium assembly. Mol Biol Cell. 2009;20:2605-14 pubmed publisher
    ..Mutants that lack Bld10 assemble centrioles and form functional centrosomes, but centrioles and spermatid basal bodies are short in length...
  2. Fu J, Glover D. Structured illumination of the interface between centriole and peri-centriolar material. Open Biol. 2012;2:120104 pubmed publisher
    The increase in centrosome size in mitosis was described over a century ago, and yet it is poorly understood how centrioles, which lie at the core of centrosomes, organize the pericentriolar material (PCM) in this process...
  3. Lukinavicius G, Lavogina D, Orpinell M, Umezawa K, Reymond L, Garin N, et al. Selective chemical crosslinking reveals a Cep57-Cep63-Cep152 centrosomal complex. Curr Biol. 2013;23:265-70 pubmed publisher
    ..We reveal that Cep57, Cep63, and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles. Furthermore, we identify that STIL, together with HsSAS-6, resides at the proximal end of the procentriole, ..
  4. Cunha Ferreira I, Bento I, Bettencourt Dias M. From zero to many: control of centriole number in development and disease. Traffic. 2009;10:482-98 pubmed publisher
    b>Centrioles are essential for the formation of microtubule-derived structures, including cilia, flagella and centrosomes. These structures are involved in a variety of functions, from cell motility to division...
  5. Wu J, Cho H, Rhee D, Johnson D, Dunlap J, Liu Y, et al. Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication. J Cell Biol. 2008;181:475-83 pubmed publisher
    ..This inhibitory function requires centriole-associated Cdc14B catalytic activity. Together, these results suggest a potential function for Cdc14B phosphatase in maintaining the fidelity of centrosome duplication cycle...
  6. Hodges M, Scheumann N, Wickstead B, Langdale J, Gull K. Reconstructing the evolutionary history of the centriole from protein components. J Cell Sci. 2010;123:1407-13 pubmed publisher
    b>Centrioles are highly conserved structures that fulfil important cellular functions, such as nucleation of cilia and flagella (basal-body function) and organisation of pericentriolar material to form the centrosome...
  7. Azimzadeh J, Marshall W. Building the centriole. Curr Biol. 2010;20:R816-25 pubmed publisher
    b>Centrioles are conserved microtubule-based organelles that lie at the core of the animal centrosome and play a crucial role in nucleating the formation of cilia and flagella in most eukaryotes...
  8. Debec A, Sullivan W, Bettencourt Dias M. Centrioles: active players or passengers during mitosis?. Cell Mol Life Sci. 2010;67:2173-94 pubmed publisher
    b>Centrioles are cylinders made of nine microtubule (MT) triplets present in many eukaryotes. Early studies, where centrosomes were seen at the poles of the mitotic spindle led to their coining as "the organ for cell division"...
  9. Cavalier Smith T. Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution. Biol Direct. 2010;5:7 pubmed publisher
    ..Discussions on the origin of sex typically overlook its association with protozoan entry into dormant walled cysts and the likely simultaneous coevolutionary, not sequential, origin of mitosis and meiosis...
  10. Schrøder J, Schneider L, Christensen S, Pedersen L. EB1 is required for primary cilia assembly in fibroblasts. Curr Biol. 2007;17:1134-9 pubmed
    ..We conclude that localization of EB1 at the centriole/basal body is required for primary cilia assembly in fibroblasts...
  11. Wang X, Tsai J, Imai J, Lian W, Vallee R, Shi S. Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature. 2009;461:947-55 pubmed publisher
    ..duplication in dividing radial glia progenitors generates a pair of centrosomes with differently aged mother centrioles. During peak phases of neurogenesis, the centrosome retaining the old mother centriole stays in the VZ and is ..
  12. Bärenz F, Mayilo D, Gruss O. Centriolar satellites: busy orbits around the centrosome. Eur J Cell Biol. 2011;90:983-9 pubmed publisher
    ..The centrosome consists of two centrioles, which generally appear in electron microscopy as barrel-shaped structures usually composed of nine microtubule ..
  13. Nakamura A, Arai H, Fujita N. Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement. J Cell Biol. 2009;187:607-14 pubmed publisher
    ..Scc1 is cleaved by separase coincidentally with chromatin Scc1, suggesting a role of Scc1 as a connector of centrioles as well as sister chromatids. Interestingly, Scc1 depletion strongly induces centriole splitting...
  14. Schöckel L, Mockel M, Mayer B, Boos D, Stemmann O. Cleavage of cohesin rings coordinates the separation of centrioles and chromatids. Nat Cell Biol. 2011;13:966-72 pubmed publisher
    ..Following chromosome segregation, centrioles loosen their tight orthogonal arrangement, which licenses later centrosome duplication in S phase...
  15. Kim T, Park J, Shukla A, Choi S, Murugan R, Lee J, et al. Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152. Proc Natl Acad Sci U S A. 2013;110:E4849-57 pubmed publisher
    ..They are composed of two orthogonally arranged centrioles, whose duplication occurs only once per cell cycle...
  16. Courtois A, Schuh M, Ellenberg J, Hiiragi T. The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development. J Cell Biol. 2012;198:357-70 pubmed publisher
    ..which the spindle is self-assembled from randomly distributed microtubule-organizing centers (MTOCs) without centrioles, because of the concerted activity of dynein and kinesin-5...
  17. Rodrigues Martins A, Riparbelli M, Callaini G, Glover D, Bettencourt Dias M. Revisiting the role of the mother centriole in centriole biogenesis. Science. 2007;316:1046-50 pubmed
    b>Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication...
  18. Meehl J, Giddings T, Winey M. High pressure freezing, electron microscopy, and immuno-electron microscopy of Tetrahymena thermophila basal bodies. Methods Mol Biol. 2009;586:227-41 pubmed publisher
    ..In combination with identification and manipulation of a rapidly expanding list of basal body-associated gene products, these methods are being used to increase our understanding of basal body composition, assembly, and function...
  19. Lucas E, Raff J. Maintaining the proper connection between the centrioles and the pericentriolar matrix requires Drosophila centrosomin. J Cell Biol. 2007;178:725-32 pubmed
    Centrosomes consist of two centrioles surrounded by an amorphous pericentriolar matrix (PCM), but it is unknown how centrioles and PCM are connected...
  20. Stowe T, Wilkinson C, Iqbal A, Stearns T. The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. Mol Biol Cell. 2012;23:3322-35 pubmed publisher
    ..Finally, we show that loss of centriolar satellites in zebrafish leads to phenotypes consistent with cilium dysfunction and analogous to those observed in human ciliopathies...
  21. Balestra F, Strnad P, Flückiger I, GONCZY P. Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells. Dev Cell. 2013;25:555-71 pubmed publisher
    b>Centrioles are essential for forming cilia, flagella, and centrosomes and are thus critical for a range of fundamental cellular processes...
  22. Xu B, Hao Z, Jha K, Zhang Z, Urekar C, Digilio L, et al. TSKS concentrates in spermatid centrioles during flagellogenesis. Dev Biol. 2008;319:201-10 pubmed publisher
    ..In this study, the substrate of TSSK1 and 2, TSKS, was localized during spermiogenesis to the centrioles of post-meiotic spermatids, where it reached its greatest concentration during the period of flagellogenesis...
  23. Klos Dehring D, Vladar E, Werner M, Mitchell J, Hwang P, Mitchell B. Deuterosome-mediated centriole biogenesis. Dev Cell. 2013;27:103-12 pubmed publisher
    The ability of cells to faithfully duplicate their two centrioles once per cell cycle is critical for proper mitotic progression and chromosome segregation...
  24. Keller L, Geimer S, Romijn E, Yates J, Zamora I, Marshall W. Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control. Mol Biol Cell. 2009;20:1150-66 pubmed publisher
    b>Centrioles are intriguing cylindrical organelles composed of triplet microtubules. Proteomic data suggest that a large number of proteins besides tubulin are necessary for the formation and maintenance of a centriole's complex structure...
  25. Kleylein Sohn J, Westendorf J, Le Clech M, Habedanck R, Stierhof Y, Nigg E. Plk4-induced centriole biogenesis in human cells. Dev Cell. 2007;13:190-202 pubmed
    ..whereas Cep135 and CPAP formed a core structure within the proximal lumen of both parental and nascent centrioles. Finally, CP110 was recruited early and then associated with the growing distal tips, indicating that centrioles ..
  26. Pearson C, Giddings T, Winey M. Basal body components exhibit differential protein dynamics during nascent basal body assembly. Mol Biol Cell. 2009;20:904-14 pubmed publisher
    ..The bimodal dynamics found for centrin and Sas6a reveal unique protein assembly mechanisms at basal bodies that may reflect novel functions for these important basal body and centriolar proteins. ..
  27. Gudi R, Zou C, Li J, Gao Q. Centrobin-tubulin interaction is required for centriole elongation and stability. J Cell Biol. 2011;193:711-25 pubmed publisher
    ..1-associated protein (CPAP) and CP110. The function of centrobin is also required for the elongation of centrioles, which is likely mediated by its interaction with tubulin...
  28. Le Clech M. Role of CAP350 in centriolar tubule stability and centriole assembly. PLoS ONE. 2008;3:e3855 pubmed publisher
    b>Centrioles are microtubule-based cylindrical structures composed of nine triplet tubules and are required for the formation of the centrosome, flagella and cilia. Despite theirs importance, centriole biogenesis is poorly understood...
  29. Prosser S, Samant M, Baxter J, Morrison C, Fry A. Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification. J Cell Sci. 2012;125:5353-68 pubmed publisher
    Centrosome duplication is licensed by the disengagement, or 'uncoupling', of centrioles during late mitosis. However, arrest of cells in G2 can trigger premature centriole disengagement...
  30. Pearson C, Culver B, Winey M. Centrioles want to move out and make cilia. Dev Cell. 2007;13:319-21 pubmed
    Cilia formation in mammalian cells requires basal bodies that are either derived from centrioles that transition from their cytoplasmic role in centrosome organization or that form en masse in multiciliated cells...
  31. O TOOLE E, Greenan G, Lange K, Srayko M, MULLER REICHERT T. The role of ?-tubulin in centrosomal microtubule organization. PLoS ONE. 2012;7:e29795 pubmed publisher
  32. Tang C, Lin S, Hsu W, Lin Y, Wu C, Lin Y, et al. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. EMBO J. 2011;30:4790-804 pubmed publisher
    ..Together, our results indicate that the two MCPH-associated proteins STIL and CPAP interact with each other and are required for procentriole formation, implying a central role of centriole biogenesis in MCPH...
  33. Korzeniewski N, Zheng L, Cuevas R, Parry J, Chatterjee P, Anderton B, et al. Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels. Cancer Res. 2009;69:6668-75 pubmed publisher
    ..Here, we show that the core SKP1-cullin-F-box component cullin 1 (CUL1) localizes to maternal centrioles and that CUL1 is critical for suppressing centriole overduplication through multiplication, a recently ..
  34. Januschke J, Gonzalez C. The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts. J Cell Biol. 2010;188:693-706 pubmed publisher
    ..We have also found that the span of such memory is limited to the last mitosis. Furthermore, the orientation of the NB axis of polarity can be reset to any angle with respect to the surrounding tissue and is, therefore, cell autonomous...
  35. Schmidt T, Kleylein Sohn J, Westendorf J, Le Clech M, Lavoie S, Stierhof Y, et al. Control of centriole length by CPAP and CP110. Curr Biol. 2009;19:1005-11 pubmed publisher
    b>Centrioles function as the major components of centrosomes, which organize microtubule (MT) arrays in proliferating cells, and as basal bodies for primary cilia formation in quiescent cells...
  36. Wilkinson C, Carl M, Harris W. Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos. BMC Cell Biol. 2009;10:17 pubmed publisher
    ..Many centrosome proteins have been identified but the roles of most are still poorly understood. The centrioles of the centrosome are similar to the basal bodies of cilia, hair-like extensions of many cells that have ..
  37. Kobayashi T, Dynlacht B. Regulating the transition from centriole to basal body. J Cell Biol. 2011;193:435-44 pubmed publisher
    The role of centrioles changes as a function of the cell cycle. Centrioles promote formation of spindle poles in mitosis and act as basal bodies to assemble primary cilia in interphase...
  38. Graser S, Stierhof Y, Lavoie S, Gassner O, Lamla S, Le Clech M, et al. Cep164, a novel centriole appendage protein required for primary cilium formation. J Cell Biol. 2007;179:321-30 pubmed
    ..By immunogold electron microscopy, Cep164 could be localized to the distal appendages of mature centrioles. In contrast to ninein and Cep170, two components of subdistal appendages, Cep164 persisted at centrioles ..
  39. Salisbury J. A mechanistic view on the evolutionary origin for centrin-based control of centriole duplication. J Cell Physiol. 2007;213:420-8 pubmed
    ..This model provides an evolutionary basis for the preservation of essential features of the yeast spindle pole body (SPB) with the origin of the complex structure of the mammalian centriole...
  40. Gogendeau D, Basto R. Centrioles in flies: the exception to the rule?. Semin Cell Dev Biol. 2010;21:163-73 pubmed publisher
    b>Centrioles and basal bodies are MT based structures that present a highly conserved ninefold symmetry...
  41. McNally K, Fabritius A, Ellefson M, Flynn J, Milan J, McNally F. Kinesin-1 prevents capture of the oocyte meiotic spindle by the sperm aster. Dev Cell. 2012;22:788-98 pubmed publisher
    b>Centrioles are lost during oogenesis and inherited from the sperm at fertilization. In the zygote, the centrioles recruit pericentriolar proteins from the egg to form a mature centrosome that nucleates a sperm aster...
  42. Dix C, Raff J. Drosophila Spd-2 recruits PCM to the sperm centriole, but is dispensable for centriole duplication. Curr Biol. 2007;17:1759-64 pubmed
    ..upstream component of this module, and it is also essential for pericentriolar material (PCM) recruitment to the centrioles [1, 4, 15, 16]...
  43. Brito D, Gouveia S, Bettencourt Dias M. Deconstructing the centriole: structure and number control. Curr Opin Cell Biol. 2012;24:4-13 pubmed publisher
    b>Centrioles are very small microtubule-based organelles essential for centrosome, cilia and flagella assembly, which are involved in a variety of cellular and developmental processes...
  44. Archinti M, Lacasa C, Teixido Travesa N, Lüders J. SPICE--a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. J Cell Sci. 2010;123:3039-46 pubmed publisher
    ..of the mitotic spindle are organized by centrosomes, microtubule-organizing structures composed of a pair of centrioles surrounded by the so-called pericentriolar material...
  45. Peel N, Stevens N, Basto R, Raff J. Overexpressing centriole-replication proteins in vivo induces centriole overduplication and de novo formation. Curr Biol. 2007;17:834-43 pubmed
    ..Centrosomes consist of a pair of centrioles surrounded by a pericentriolar matrix (PCM), and their replication is tightly regulated...
  46. Marshall W. Centriole evolution. Curr Opin Cell Biol. 2009;21:14-9 pubmed publisher
    b>Centrioles are cylindrical structures found at the core of the mitotic spindle pole, which also act as basal bodies to nucleate the formation of cilia...
  47. Riparbelli M, Callaini G. Male gametogenesis without centrioles. Dev Biol. 2011;349:427-39 pubmed publisher
    ..that spindle alignment and asymmetric divisions are properly executed in male germline stem cells that lack centrioles. Spermatogonial divisions also correctly proceed in the absence of centrioles, giving rise to cysts of 16 ..
  48. Blachon S, Gopalakrishnan J, Omori Y, Polyanovsky A, Church A, Nicastro D, et al. Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication. Genetics. 2008;180:2081-94 pubmed publisher
    ..The clear absence of several centriolar markers in mecD mutants suggests that Asl is critical early in centriole duplication...
  49. Kitagawa D, Busso C, Flückiger I, GONCZY P. Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos. Dev Cell. 2009;17:900-7 pubmed publisher
    ..Overall, our findings establish that phosphorylation of the evolutionarily conserved protein SAS-6 is critical for centriole formation and thus for faithful cell division...
  50. Bettencourt Dias M, Carvalho Santos Z. Double life of centrioles: CP110 in the spotlight. Trends Cell Biol. 2008;18:8-11 pubmed
    b>Centrioles lead an important double life: they can give rise to the centrosome or convert to basal bodies and template cilia. Little is known about the control of centriole fate...
  51. Lopes C, Prosser S, Romio L, Hirst R, O Callaghan C, Woolf A, et al. Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome 1. J Cell Sci. 2011;124:600-12 pubmed publisher
    ..Furthermore, definition of how OFD1 and PCM-1 interact helps explain why different OFD1 mutations lead to clinically variable phenotypes...
  52. Dzhindzhev N, Yu Q, Weiskopf K, Tzolovsky G, Cunha Ferreira I, Riparbelli M, et al. Asterless is a scaffold for the onset of centriole assembly. Nature. 2010;467:714-8 pubmed publisher
    b>Centrioles are found in the centrosome core and, as basal bodies, at the base of cilia and flagella...
  53. Brownlee C, Klebba J, Buster D, Rogers G. The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification. J Cell Biol. 2011;195:231-43 pubmed publisher
    ..duplication is a tightly regulated process that must occur only once per cell cycle; otherwise, supernumerary centrioles can induce aneuploidy and tumorigenesis...