peroxisomes

Summary

Summary: Microbodies which occur in animal and plant cells and in certain fungi and protozoa. They contain peroxidase, catalase, and allied enzymes. (From Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology, 2nd ed)

Top Publications

  1. Schliebs W, Girzalsky W, Erdmann R. Peroxisomal protein import and ERAD: variations on a common theme. Nat Rev Mol Cell Biol. 2010;11:885-90 pubmed publisher
    ..functions, there is a surprising similarity between the composition of the machinery that imports proteins into peroxisomes and the machinery that degrades endoplasmic reticulum (ER)-associated proteins...
  2. Gronemeyer T, Wiese S, Grinhagens S, Schollenberger L, Satyagraha A, Huber L, et al. Localization of Rab proteins to peroxisomes: a proteomics and immunofluorescence study. FEBS Lett. 2013;587:328-38 pubmed publisher
    A proteomics screen was initiated to identify Rab proteins regulating transport to and away from peroxisomes. Mass spectrometry-based protein correlation profiling of rat liver organelles and immunofluorescence analysis of the peroxisome ..
  3. Kaur N, Li J, Hu J. Peroxisomes and photomorphogenesis. Subcell Biochem. 2013;69:195-211 pubmed publisher
    ..Possible mechanisms underlying this phenomenon are discussed. ..
  4. Sandalio L, Rodríguez Serrano M, Romero Puertas M, del Rio L. Role of peroxisomes as a source of reactive oxygen species (ROS) signaling molecules. Subcell Biochem. 2013;69:231-55 pubmed publisher
    b>Peroxisomes are very dynamic and metabolically active organelles and are a very important source of reactive oxygen species (ROS), H2O2, O2 (...
  5. Schuhmann H, Adamska I. Deg proteases and their role in protein quality control and processing in different subcellular compartments of the plant cell. Physiol Plant. 2012;145:224-34 pubmed publisher
    ..genome of Arabidopsis thaliana, six of which were experimentally shown to be located in chloroplasts, one in peroxisomes, one in mitochondria and one in the nucleus...
  6. Spiess G, Zolman B. Peroxisomes as a source of auxin signaling molecules. Subcell Biochem. 2013;69:257-81 pubmed publisher
    b>Peroxisomes house many metabolic processes that allow organisms to safely sequester reactions with potentially damaging byproducts...
  7. Singh J, Khan M, Singh I. HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes. J Lipid Res. 2011;52:2056-69 pubmed publisher
    ..These observations indicate that SAHA corrects both the metabolic disease of VLCFA as well as secondary inflammatory disease; therefore, it may be an ideal drug candidate to be tested for X-ALD therapy in humans...
  8. Kassmann C, Quintes S, Rietdorf J, Mobius W, Sereda M, Nientiedt T, et al. A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity. FEBS Lett. 2011;585:2205-11 pubmed publisher
    ..Here we show by confocal and electron microscopy that in myelin-forming glia peroxisomes are associated with myelin membranes...
  9. Goto S, Mano S, Nakamori C, Nishimura M. Arabidopsis ABERRANT PEROXISOME MORPHOLOGY9 is a peroxin that recruits the PEX1-PEX6 complex to peroxisomes. Plant Cell. 2011;23:1573-87 pubmed publisher
    b>Peroxisomes have pivotal roles in several metabolic processes, such as the detoxification of H?O? and ?-oxidation of fatty acids, and their functions are tightly regulated by multiple factors involved in peroxisome biogenesis, including ..

More Information

Publications62

  1. van der Zand A, Tabak H. Peroxisomes: offshoots of the ER. Curr Opin Cell Biol. 2013;25:449-54 pubmed publisher
    b>Peroxisomes are part of the ubiquitous set of eukaryotic organelles. They are small, single membrane bounded vesicles, specialized in the degradation of very-long-chain fatty acids and in synthesis of myelin lipids...
  2. Platta H, Hagen S, Erdmann R. The exportomer: the peroxisomal receptor export machinery. Cell Mol Life Sci. 2013;70:1393-411 pubmed publisher
    b>Peroxisomes constitute a dynamic compartment of almost all eukaryotic cells. Depending on environmental changes and cellular demands peroxisomes can acquire diverse metabolic roles...
  3. Liu X, Subramani S. Unique requirements for mono- and polyubiquitination of the peroxisomal targeting signal co-receptor, Pex20. J Biol Chem. 2013;288:7230-40 pubmed publisher
    ..This is the first description of the complete ubiquitination pathway of Pex20, which provides a better understanding of the recycling and degradation of this PTS2 cargo co-receptor...
  4. Hamada T, Tominaga M, Fukaya T, Nakamura M, Nakano A, Watanabe Y, et al. RNA processing bodies, peroxisomes, Golgi bodies, mitochondria, and endoplasmic reticulum tubule junctions frequently pause at cortical microtubules. Plant Cell Physiol. 2012;53:699-708 pubmed publisher
    ..Similarly, we show that Golgi bodies, peroxisomes, and mitochondria all pause at microtubules, and again the frequency of pauses is not appreciably changed after ..
  5. Grou C, Francisco T, Rodrigues T, Freitas M, Pinto M, Carvalho A, et al. Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate. J Biol Chem. 2012;287:12815-27 pubmed publisher
    ..The strategy described here will be useful in identifying deubiquitinases acting on other ubiquitin conjugates...
  6. Ching S, Gidda S, Rochon A, Van Cauwenberghe O, Shelp B, Mullen R. Glyoxylate reductase isoform 1 is localized in the cytosol and not peroxisomes in plant cells. J Integr Plant Biol. 2012;54:152-68 pubmed publisher
    ..GLYR2, and while GLYR2 is known to be localized in plastids, GLYR1 has been reported to be localized in either peroxisomes or the cytosol. Here, we reappraised the intracellular localization of GLYR1 in Arabidopsis thaliana L...
  7. Cepińska M, Veenhuis M, van der Klei I, Nagotu S. Peroxisome fission is associated with reorganization of specific membrane proteins. Traffic. 2011;12:925-37 pubmed publisher
    ..We speculate that peroxin reorganization events result in enhanced levels of peroxins involved in peroxisome biogenesis in nascent organelles...
  8. Aung K, Hu J. The Arabidopsis tail-anchored protein PEROXISOMAL AND MITOCHONDRIAL DIVISION FACTOR1 is involved in the morphogenesis and proliferation of peroxisomes and mitochondria. Plant Cell. 2011;23:4446-61 pubmed publisher
    b>Peroxisomes and mitochondria are multifunctional eukaryotic organelles that are not only interconnected metabolically but also share proteins in division...
  9. Chigri F, Flosdorff S, Pilz S, Kölle E, Dolze E, Gietl C, et al. The Arabidopsis calmodulin-like proteins AtCML30 and AtCML3 are targeted to mitochondria and peroxisomes, respectively. Plant Mol Biol. 2012;78:211-22 pubmed publisher
    ..established, there is growing evidence for the inclusion of organelles such as chloroplasts, mitochondria and peroxisomes into the calcium/calmodulin regulation network...
  10. Mast F, Fagarasanu A, Knoblach B, Rachubinski R. Peroxisome biogenesis: something old, something new, something borrowed. Physiology (Bethesda). 2010;25:347-56 pubmed publisher
    ..One set of membrane-bound, usually spherical compartments are commonly grouped together under the term peroxisomes. Peroxisomes function in regulating the synthesis and availability of many diverse lipids by harnessing the ..
  11. Okumoto K, Kametani Y, Fujiki Y. Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid ?-oxidation in peroxisomal matrix. J Biol Chem. 2011;286:44367-79 pubmed publisher
    ..The proteolytic activity of oligomeric Tysnd1 is in turn controlled by self-cleavage of Tysnd1 and degradation of Tysnd1 cleavage products by PsLon...
  12. Opaliński Ł, Veenhuis M, van der Klei I. Peroxisomes: membrane events accompanying peroxisome proliferation. Int J Biochem Cell Biol. 2011;43:847-51 pubmed publisher
    b>Peroxisomes are ubiquitous organelles surrounded by a single membrane that display a variety of metabolic functions. These vary with the organism in which they occur and with environmental conditions...
  13. Williams C, van der Klei I. Pexophagy-linked degradation of the peroxisomal membrane protein Pex3p involves the ubiquitin-proteasome system. Biochem Biophys Res Commun. 2013;438:395-401 pubmed publisher
    Peroxisome autophagy, also known as pexophagy, describes the wholesale degradation of peroxisomes via the vacuole, when organelles become damaged or redundant...
  14. Agrawal G, Joshi S, Subramani S. Cell-free sorting of peroxisomal membrane proteins from the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2011;108:9113-8 pubmed publisher
    Several yeast and mammalian peroxisomal membrane proteins (PMPs) are delivered to peroxisomes via the endoplasmic reticulum (ER)...
  15. Yagita Y, Hiromasa T, Fujiki Y. Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway. J Cell Biol. 2013;200:651-66 pubmed publisher
    ..Although the targeting of TA proteins to peroxisomes is dependent on PEX19, the mechanistic details of PEX19-dependent targeting and the signal that directs TA ..
  16. Fox M, Walsh L, Nieuwesteeg M, Damjanovski S. PEX11? induces peroxisomal gene expression and alters peroxisome number during early Xenopus laevis development. BMC Dev Biol. 2011;11:24 pubmed publisher
    b>Peroxisomes are organelles whose roles in fatty acid metabolism and reactive oxygen species elimination have contributed much attention in understanding their origin and biogenesis...
  17. Min K, Son H, Lee J, Choi G, Kim J, Lee Y. Peroxisome function is required for virulence and survival of Fusarium graminearum. Mol Plant Microbe Interact. 2012;25:1617-27 pubmed publisher
    b>Peroxisomes are organelles that are involved in a number of important cellular metabolic processes, including the ?-oxidation of fatty acids, biosynthesis of secondary metabolites, and detoxification of reactive oxygen species (ROS)...
  18. Deosaran E, Larsen K, Hua R, Sargent G, Wang Y, Kim S, et al. NBR1 acts as an autophagy receptor for peroxisomes. J Cell Sci. 2013;126:939-52 pubmed publisher
    ..We examined selective autophagic degradation of peroxisomes (pexophagy), and found that NBR1 is necessary and sufficient for pexophagy...
  19. Motley A, Nuttall J, Hettema E. Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae. EMBO J. 2012;31:2852-68 pubmed publisher
    b>Peroxisomes undergo rapid, selective autophagic degradation (pexophagy) when the metabolic pathways they contain are no longer required for cellular metabolism...
  20. Tabak H, Braakman I, van der Zand A. Peroxisome formation and maintenance are dependent on the endoplasmic reticulum. Annu Rev Biochem. 2013;82:723-44 pubmed publisher
    Looks can be deceiving. Although peroxisomes appear to be simple organelles, their formation and maintenance pose unique challenges for the cell...
  21. Amelina H, Sjödin M, Bergquist J, Cristobal S. Quantitative subproteomic analysis of age-related changes in mouse liver peroxisomes by iTRAQ LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2011;879:3393-400 pubmed publisher
    ..b>Peroxisomes recently emerged as another important source of reactive oxygen species (ROS) production in addition to ..
  22. Pan R, Hu J. The conserved fission complex on peroxisomes and mitochondria. Plant Signal Behav. 2011;6:870-2 pubmed
    b>Peroxisomes are eukaryotic organelles highly versatile and dynamic in content and abundance...
  23. Joshi S, Agrawal G, Subramani S. Phosphorylation-dependent Pex11p and Fis1p interaction regulates peroxisome division. Mol Biol Cell. 2012;23:1307-15 pubmed publisher
    ..PpPex11p transits to peroxisomes via the endoplasmic reticulum (ER)...
  24. Mast F, Li J, Virk M, Hughes S, Simmonds A, Rachubinski R. A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. Dis Model Mech. 2011;4:659-72 pubmed publisher
    ..b>Peroxisomes are ubiquitous membrane-bound organelles involved in several important biochemical processes, notably lipid ..
  25. Nuttall J, Motley A, Hettema E. Peroxisome biogenesis: recent advances. Curr Opin Cell Biol. 2011;23:421-6 pubmed publisher
    In recent years, it has become evident that peroxisomes form part of the endomembrane system...
  26. Gronemeyer T, Wiese S, Ofman R, Bunse C, Pawlas M, Hayen H, et al. The proteome of human liver peroxisomes: identification of five new peroxisomal constituents by a label-free quantitative proteomics survey. PLoS ONE. 2013;8:e57395 pubmed publisher
    ..To improve our knowledge of this important cellular structure, we studied for the first time human liver peroxisomes by quantitative proteomics...
  27. Otzen M, Rucktäschel R, Thoms S, Emmrich K, Krikken A, Erdmann R, et al. Pex19p contributes to peroxisome inheritance in the association of peroxisomes to Myo2p. Traffic. 2012;13:947-59 pubmed publisher
    During budding of yeast cells peroxisomes are distributed over mother cell and bud, a process that involves the myosin motor protein Myo2p and the peroxisomal membrane protein Inp2p...
  28. van Zutphen T, Veenhuis M, van der Klei I. Damaged peroxisomes are subject to rapid autophagic degradation in the yeast Hansenula polymorpha. Autophagy. 2011;7:863-72 pubmed
    ..g., mitophagy). Here we show that peroxisomes that are damaged by the abrupt removal of the membrane protein Pex3 are massively and rapidly degraded even ..
  29. Mao K, Wang K, Zhao M, Xu T, Klionsky D. Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol. 2011;193:755-67 pubmed publisher
    ..Slt2 is required for the degradation of both mitochondria and peroxisomes (via pexophagy), whereas Hog1 functions specifically in mitophagy...
  30. Kohlwein S, Veenhuis M, van der Klei I. Lipid droplets and peroxisomes: key players in cellular lipid homeostasis or a matter of fat--store 'em up or burn 'em down. Genetics. 2013;193:1-50 pubmed publisher
    Lipid droplets (LDs) and peroxisomes are central players in cellular lipid homeostasis: some of their main functions are to control the metabolic flux and availability of fatty acids (LDs and peroxisomes) as well as of sterols (LDs)...
  31. Burkhart S, Lingard M, Bartel B. Genetic dissection of peroxisome-associated matrix protein degradation in Arabidopsis thaliana. Genetics. 2013;193:125-41 pubmed publisher
    b>Peroxisomes are organelles that sequester certain metabolic pathways; many of these pathways generate H(2)O(2), which can damage proteins. However, little is known about how damaged or obsolete peroxisomal proteins are degraded...
  32. Williams C, Schueller N, Thompson C, van den Berg M, van Haren S, Erdmann R, et al. The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition. BMC Biochem. 2011;12:12 pubmed publisher
    ..In this study, we have tested the contribution of a second, ancillary receptor-cargo binding site, which was found in addition to the characterised Peroxisomal Target Signal type 1...
  33. Kawałek A, Lefevre S, Veenhuis M, van der Klei I. Peroxisomal catalase deficiency modulates yeast lifespan depending on growth conditions. Aging (Albany NY). 2013;5:67-83 pubmed
    ..These findings reveal for the first time an important role of enhanced cytochrome c peroxidase levels in yeast CLS extension...
  34. Lam S, Yoda N, Schekman R. A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2010;107:21523-8 pubmed publisher
    ..ER-peroxisome transport vesicles appear to rely on a novel budding mechanism requiring Pex19p and additional unknown factors...
  35. Ma C, Hagstrom D, Polley S, Subramani S. Redox-regulated cargo binding and release by the peroxisomal targeting signal receptor, Pex5. J Biol Chem. 2013;288:27220-31 pubmed publisher
    ..This interaction is also important for the release of PTS1 proteins. We suggest a redox-regulated model for Pex5 function during the peroxisomal matrix protein import cycle. ..
  36. Weng H, Ji X, Naito Y, Endo K, Ma X, Takahashi R, et al. Pex11? deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice. Am J Physiol Endocrinol Metab. 2013;304:E187-96 pubmed publisher
    ..b>Peroxisomes have many important functions in lipid metabolism, including fatty acid ?-oxidization...
  37. van Roermund C, Visser W, IJlst L, Waterham H, Wanders R. Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid ?-oxidation. Biochim Biophys Acta. 2011;1811:148-52 pubmed publisher
    ..Our earlier work showed that in yeast the uptake of fatty acids into peroxisomes may occur via two routes, either as (1.) free fatty acid or as (2.) acyl-CoA ester...
  38. Waterham H, Ebberink M. Genetics and molecular basis of human peroxisome biogenesis disorders. Biochim Biophys Acta. 2012;1822:1430-41 pubmed publisher
    ..In this review we describe the current status of genetic analysis and the molecular basis of PBDs...
  39. Bartoszewska M, Williams C, Kikhney A, Opaliński Ł, van Roermund C, de Boer R, et al. Peroxisomal proteostasis involves a Lon family protein that functions as protease and chaperone. J Biol Chem. 2012;287:27380-95 pubmed publisher
    ..The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln)...
  40. Koch J, Brocard C. PEX11 proteins attract Mff and human Fis1 to coordinate peroxisomal fission. J Cell Sci. 2012;125:3813-26 pubmed publisher
    ..Analysis of PEX11? mutants, which localize to peroxisomes, revealed essential domains for membrane elongation including an amphipathic region and regulatory sequences ..
  41. Baarine M, Andreoletti P, Athias A, Nury T, Zarrouk A, Ragot K, et al. Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins. Neuroscience. 2012;213:1-18 pubmed publisher
    ..Since peroxisomes are involved in the metabolism of reactive oxygen species (ROS) and nitrogen species (RNS), we examined the ..
  42. Giordano C, Terlecky S. Peroxisomes, cell senescence, and rates of aging. Biochim Biophys Acta. 2012;1822:1358-62 pubmed publisher
    ..associated with the organelle's biogenesis and function, there is a large gap in our understanding of how peroxisomes are incorporated into metabolic pathways and subcellular communication networks, how they contribute to ..
  43. Ortega Galisteo A, Rodríguez Serrano M, Pazmiño D, Gupta D, Sandalio L, Romero Puertas M. S-Nitrosylated proteins in pea (Pisum sativum L.) leaf peroxisomes: changes under abiotic stress. J Exp Bot. 2012;63:2089-103 pubmed publisher
    b>Peroxisomes, single-membrane-bounded organelles with essentially oxidative metabolism, are key in plant responses to abiotic and biotic stresses...
  44. Fransen M, Nordgren M, Wang B, Apanasets O. Role of peroxisomes in ROS/RNS-metabolism: implications for human disease. Biochim Biophys Acta. 2012;1822:1363-73 pubmed publisher
    b>Peroxisomes are cell organelles that play a central role in lipid metabolism. At the same time, these organelles generate reactive oxygen and nitrogen species as byproducts...
  45. Hu J, Baker A, Bartel B, Linka N, Mullen R, Reumann S, et al. Plant peroxisomes: biogenesis and function. Plant Cell. 2012;24:2279-303 pubmed publisher
    b>Peroxisomes are eukaryotic organelles that are highly dynamic both in morphology and metabolism...
  46. Shi R, Zhang Y, Shi Y, Shi S, Jiang L. Inhibition of peroxisomal ?-oxidation by thioridazine increases the amount of VLCFAs and A? generation in the rat brain. Neurosci Lett. 2012;528:6-10 pubmed publisher
    ..This work supports an emerging viewpoint that impaired peroxisomal function may play an important role in the progression of AD pathology...
  47. Bonekamp N, Sampaio P, de Abreu F, Lüers G, Schrader M. Transient complex interactions of mammalian peroxisomes without exchange of matrix or membrane marker proteins. Traffic. 2012;13:960-78 pubmed publisher
    b>Peroxisomes and mitochondria show a much closer interrelationship than previously anticipated. They co-operate in the metabolism of fatty acids and reactive oxygen species, but also share components of their fission machinery...
  48. Islinger M, Grille S, Fahimi H, Schrader M. The peroxisome: an update on mysteries. Histochem Cell Biol. 2012;137:547-74 pubmed publisher
    b>Peroxisomes contribute to several crucial metabolic processes such as ?-oxidation of fatty acids, biosynthesis of ether phospholipids and metabolism of reactive oxygen species, which render them indispensable to human health and ..
  49. Mano S, Nakamori C, Fukao Y, Araki M, Matsuda A, Kondo M, et al. A defect of peroxisomal membrane protein 38 causes enlargement of peroxisomes. Plant Cell Physiol. 2011;52:2157-72 pubmed publisher
    Peroxisome proliferation occurs through enlargement, elongation and division of pre-existing peroxisomes. In the Arabidopsis apem mutant, apem3, peroxisomes are dramatically enlarged and reduced in number, revealing a defect in ..
  50. Dastig S, Nenicu A, Otte D, Zimmer A, Seitz J, Baumgart Vogt E, et al. Germ cells of male mice express genes for peroxisomal metabolic pathways implicated in the regulation of spermatogenesis and the protection against oxidative stress. Histochem Cell Biol. 2011;136:413-25 pubmed publisher
    b>Peroxisomes are organelles with main functions in the metabolism of lipids and of reactive oxygen species. Within the testis, they have different functional profiles depending on the cell types...
  51. Debelyy M, Platta H, Saffian D, Hensel A, Thoms S, Meyer H, et al. Ubp15p, a ubiquitin hydrolase associated with the peroxisomal export machinery. J Biol Chem. 2011;286:28223-34 pubmed publisher
    ..Ubp15p partially localizes to peroxisomes and is capable of cleaving off ubiquitin moieties from the type I peroxisomal targeting sequence (PTS1) ..
  52. Ribeiro D, Castro I, Fahimi H, Schrader M. Peroxisome morphology in pathology. Histol Histopathol. 2012;27:661-76 pubmed publisher
    b>Peroxisomes are remarkably dynamic and versatile organelles that are essential for human health and development...
  53. Schrader M, Almeida M, Grille S. Postfixation detergent treatment liberates the membrane modelling protein Pex11? from peroxisomal membranes. Histochem Cell Biol. 2012;138:541-7 pubmed publisher
    Pex11 proteins are involved in membrane remodelling processes of peroxisomes, and are key components of peroxisomal division and proliferation. In mammals, three Pex11 isoforms, Pex11?, Pex11?, and Pex11? exist...