mucus

Summary

Summary: The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.

Top Publications

  1. Gundavarapu S, Wilder J, Mishra N, Rir Sima Ah J, Langley R, Singh S, et al. Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo. J Allergy Clin Immunol. 2012;130:770-780.e11 pubmed publisher
    Airway mucus hypersecretion is a key pathophysiologic feature in a number of lung diseases. Cigarette smoke/nicotine and allergens are strong stimulators of airway mucus; however, the mechanism of mucus modulation is unclear.
  2. Anagnostopoulou P, Riederer B, Duerr J, Michel S, Binia A, Agrawal R, et al. SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation. J Clin Invest. 2012;122:3629-34 pubmed publisher
    ..in wild-type and Slc26a9-deficient mice and compared the effects on airway ion transport, morphology, and mucus content...
  3. Kesimer M, Ehre C, Burns K, Davis C, Sheehan J, Pickles R. Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways. Mucosal Immunol. 2013;6:379-92 pubmed publisher
    b>Mucus, with its burden of inspired particulates and pathogens, is cleared from mucosal surfaces of the airways by cilia beating within the periciliary layer (PCL)...
  4. Button B, Cai L, Ehre C, Kesimer M, Hill D, Sheehan J, et al. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science. 2012;337:937-41 pubmed publisher
    b>Mucus clearance is the primary defense mechanism that protects airways from inhaled infectious and toxic agents...
  5. Jakab R, Collaco A, Ameen N. Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility. Dig Dis Sci. 2012;57:2826-45 pubmed publisher
    ..The aim of this study was to determine whether lubiprostone exerts secretory effects in the intestine by membrane trafficking of ion transporters and associated machinery...
  6. Kirch J, Schneider A, Abou B, Hopf A, Schaefer U, Schneider M, et al. Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus. Proc Natl Acad Sci U S A. 2012;109:18355-60 pubmed publisher
    In this study, the mobility of nanoparticles in mucus and similar hydrogels as model systems was assessed to elucidate the link between microscopic diffusion behavior and macroscopic penetration of such gels...
  7. Hasnain S, Tauro S, Das I, Tong H, Chen A, Jeffery P, et al. IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology. 2013;144:357-368.e9 pubmed publisher
    ..However, it is not clear how immune factors affect ER stress and therefore disease symptoms...
  8. Gustafsson J, Ermund A, Ambort D, Johansson M, Nilsson H, Thorell K, et al. Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype. J Exp Med. 2012;209:1263-72 pubmed publisher
    ..and bicarbonate ion channel (CF transmembrane regulator [CFTR]), but the link to the phenomenon of stagnant mucus is not well understood...
  9. Lynch J, Sonnenburg J. Prioritization of a plant polysaccharide over a mucus carbohydrate is enforced by a Bacteroides hybrid two-component system. Mol Microbiol. 2012;85:478-91 pubmed publisher
    ..We also found that BT0366 activation simultaneously leads to repression of distal PULs involved in mucus carbohydrate consumption...

More Information

Publications62

  1. Singh A, Xia W, Riederer B, Jurić M, Li J, Zheng W, et al. Essential role of the electroneutral Na+-HCO3- cotransporter NBCn1 in murine duodenal acid-base balance and colonic mucus layer build-up in vivo. J Physiol. 2013;591:2189-204 pubmed publisher
    ..of the lumen, while colonic mucosa counteracts damage by pathogens by building up a bacteria-free adherent mucus layer...
  2. Oehlers S, Flores M, Hall C, Crosier K, Crosier P. Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis. Dis Model Mech. 2012;5:457-67 pubmed publisher
    ..The intestinal mucus layer is an important structural barrier that is disrupted in IBD...
  3. Lee M, Shin I, Jeon W, Lim H, Kim J, Ha H. Pinellia ternata Breitenbach attenuates ovalbumin-induced allergic airway inflammation and mucus secretion in a murine model of asthma. Immunopharmacol Immunotoxicol. 2013;35:410-8 pubmed publisher
    ..Pinellia ternata is an important plant in traditional Chinese medicine. This study describes the anti-inflammatory effects of a water extract of P. ternata (PTE) in allergic airway inflammation in a model of asthma in mice...
  4. Gustafsson J, Ermund A, Johansson M, Schütte A, Hansson G, Sjovall H. An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants. Am J Physiol Gastrointest Liver Physiol. 2012;302:G430-8 pubmed publisher
    The colon mucus layers minimize the contact between the luminal flora and the epithelial cells, and defects in this barrier may lead to colonic inflammation...
  5. Livraghi Butrico A, Grubb B, Kelly E, Wilkinson K, Yang H, Geiser M, et al. Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction. Physiol Genomics. 2012;44:470-84 pubmed publisher
    b>Mucus clearance is an important airway innate defense mechanism...
  6. Cohen M, Zhang X, Senaati H, Chen H, Varki N, Schooley R, et al. Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase. Virol J. 2013;10:321 pubmed publisher
    ..The role of NA in viral entry remains unclear. Host respiratory epithelia secrete a mucus layer rich in heavily sialylated glycoproteins; these could inhibit viral entry by mimicking sialylated receptors ..
  7. Johansson M, Sjovall H, Hansson G. The gastrointestinal mucus system in health and disease. Nat Rev Gastroenterol Hepatol. 2013;10:352-61 pubmed publisher
    ..apical surface covered by transmembrane mucins and goblet cells produce the secreted gel-forming mucins that form mucus. The small intestine has a single unattached mucus layer, which in cystic fibrosis becomes attached, accounting ..
  8. Schreiber O, Petersson J, Waldén T, Ahl D, Sandler S, Phillipson M, et al. iNOS-dependent increase in colonic mucus thickness in DSS-colitic rats. PLoS ONE. 2013;8:e71843 pubmed publisher
    To investigate colonic mucus thickness in vivo in health and during experimental inflammatory bowel disease.
  9. Thiara G, Goldman R. Milk consumption and mucus production in children with asthma. Can Fam Physician. 2012;58:165-6 pubmed
    ..add milk to their children's diet because they believe it will worsen their children's asthma owing to increased mucus secretion...
  10. Saxena A, Baliga M, Ponemone V, Kaur K, Larsen B, Fletcher E, et al. Mucus and adiponectin deficiency: role in chronic inflammation-induced colon cancer. Int J Colorectal Dis. 2013;28:1267-79 pubmed publisher
    ..APN) in preventing goblet cell apoptosis and in differentiation of epithelial cells to goblet cell lineage resulting in greater mucus production and hence greater protection from chronic inflammation-induced colon cancer (CICC).
  11. Navabi N, McGuckin M, Linden S. Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation. PLoS ONE. 2013;8:e68761 pubmed publisher
    ..in vivo mucosal surface, are often not polarized, lack important components of the glycocalyx, and often lack the mucus layer...
  12. Rodríguez Piñeiro A, Bergström J, Ermund A, Gustafsson J, Schütte A, Johansson M, et al. Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins. Am J Physiol Gastrointest Liver Physiol. 2013;305:G348-56 pubmed publisher
    The mucus that protects the surface of the gastrointestinal tract is rich in specialized O-glycoproteins called mucins, but little is known about other mucus proteins or their variability along the gastrointestinal tract...
  13. Schuster B, Suk J, Woodworth G, Hanes J. Nanoparticle diffusion in respiratory mucus from humans without lung disease. Biomaterials. 2013;34:3439-46 pubmed publisher
    A major role of respiratory mucus is to trap inhaled particles, including pathogens and environmental particulates, to limit body exposure...
  14. Watanabe M, Kinoshita H, Huang I, Eguchi K, Tsurumi T, Kawai Y, et al. An adhesin-like protein, Lam29, from Lactobacillus mucosae ME-340 binds to histone H3 and blood group antigens in human colonic mucus. Biosci Biotechnol Biochem. 2012;76:1655-60 pubmed
    ..In addition, here we report that Lam29 also bound to an 18-kDa protein on human colonic mucus. By ligand blot assay and N-terminal amino acid sequence of the protein, it was identified as human histone H3...
  15. Johansson M, Hansson G. Mucus and the goblet cell. Dig Dis. 2013;31:305-9 pubmed publisher
    The discovery of an inner mucus layer normally impervious to bacteria has changed our way of understanding the interaction between commensal bacteria and the host epithelial cells...
  16. Cattoir V, Narasimhan G, Skurnik D, Aschard H, Roux D, Ramphal R, et al. Transcriptional response of mucoid Pseudomonas aeruginosa to human respiratory mucus. MBio. 2013;3:e00410-12 pubmed publisher
    ..isolate from a CF patient was determined following growth of the bacteria in the presence of human respiratory mucus. This stable mucoid strain responded to a number of regulatory inputs from the mucus, resulting in an unexpected ..
  17. Yang X, Forier K, Steukers L, Van Vlierberghe S, Dubruel P, Braeckmans K, et al. Immobilization of pseudorabies virus in porcine tracheal respiratory mucus revealed by single particle tracking. PLoS ONE. 2012;7:e51054 pubmed publisher
    ..Another important but often overlooked barrier is the substantial mucus layer which coats the mucosae...
  18. Tarran R, Sabater J, Clarke T, Tan C, Davies C, Liu J, et al. Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion. Am J Physiol Lung Cell Mol Physiol. 2013;304:L746-56 pubmed publisher
    b>Mucus clearance is an important component of the lung's innate defense system. A failure of this system brought on by mucus dehydration is common to both cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD)...
  19. Johansson M, Gustafsson J, Holmén Larsson J, Jabbar K, Xia L, Xu H, et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut. 2014;63:281-91 pubmed publisher
    The inner mucus layer in mouse colon normally separates bacteria from the epithelium...
  20. Long Y, Li Q, Zhou B, Song G, Li T, Cui Z. De novo assembly of mud loach (Misgurnus anguillicaudatus) skin transcriptome to identify putative genes involved in immunity and epidermal mucus secretion. PLoS ONE. 2013;8:e56998 pubmed publisher
    ..Secretion of mucus is among the most prominent characteristics of fish skin and numerous innate immune factors have been identified ..
  21. Varum F, Veiga F, Sousa J, Basit A. Mucus thickness in the gastrointestinal tract of laboratory animals. J Pharm Pharmacol. 2012;64:218-27 pubmed publisher
    The objective of this study was to systematically assess the mucus thickness in the gastrointestinal tract of laboratory animals commonly used in preclinical studies.
  22. Lillehoj E, Kato K, Lu W, Kim K. Cellular and molecular biology of airway mucins. Int Rev Cell Mol Biol. 2013;303:139-202 pubmed publisher
    Airway mucus constitutes a thin layer of airway surface liquid with component macromolecules that covers the luminal surface of the respiratory tract...
  23. Alemka A, Corcionivoschi N, Bourke B. Defense and adaptation: the complex inter-relationship between Campylobacter jejuni and mucus. Front Cell Infect Microbiol. 2012;2:15 pubmed publisher
    b>Mucus colonization is an essential early step toward establishing successful infection and disease by mucosal pathogens...
  24. Haley C, Colmer Hamood J, Hamood A. Characterization of biofilm-like structures formed by Pseudomonas aeruginosa in a synthetic mucus medium. BMC Microbiol. 2012;12:181 pubmed publisher
    The accumulation of thick stagnant mucus provides a suitable environment for the growth of Pseudomonas aeruginosa and Staphylococcus aureus within the lung alveoli of cystic fibrosis (CF) patients...
  25. Van Tassell M, Miller M. Lactobacillus adhesion to mucus. Nutrients. 2011;3:613-36 pubmed publisher
    b>Mucus provides protective functions in the gastrointestinal tract and plays an important role in the adhesion of microorganisms to host surfaces...
  26. Serra M, Anjos Valotta E, Olsen P, Couto G, Jurgilas P, Cotias A, et al. Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma. Anesthesiology. 2012;117:580-91 pubmed publisher
    ..The aim of this study was to assess the impact of lidocaine treatment using a murine model of allergic asthma characterized by expression of pivotal features of the disease: inflammation, mucus production, and lung remodeling.
  27. Chen E, Daley D, Wang Y, Garnica M, Chen C, Chin W. Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration. Sci Rep. 2012;2:211 pubmed publisher
    Luminal accumulation of viscous, poorly hydrated, and less transportable mucus has been associated with altered mucus rheology and reduced mucociliary clearance...
  28. Nie Y, Wu H, Li P, Luo Y, Zhang C, Shen J, et al. Characteristic comparison of three rat models induced by cigarette smoke or combined with LPS: to establish a suitable model for study of airway mucus hypersecretion in chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2012;25:349-56 pubmed publisher
    There is a need of in vivo COPD models for mucus hypersecretion study. The current study compared three rat models induced by cigarette smoke (CS) exposure alone or combined with pre- or post-treatment with lipopolysaccharide (LPS)...
  29. Iwashita H, Fujimoto K, Morita S, Nakanishi A, Kubo K. Increased human Ca²?-activated Cl? channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients. Respir Res. 2012;13:55 pubmed publisher
    The mechanisms underlying the association between smoking and mucus overproduction remain unknown...
  30. D Agostino E, Rossetti D, Atkins D, Ferdinando D, Yakubov G. Interaction of tea polyphenols and food constituents with model gut epithelia: the protective role of the mucus gel layer. J Agric Food Chem. 2012;60:3318-28 pubmed publisher
    The luminal surface of the gastrointestinal tract is covered by a mucus gel layer that acts to protect gut epithelial cells from the harsh luminal environment...
  31. McKew B, Dumbrell A, Daud S, Hepburn L, Thorpe E, Mogensen L, et al. Characterization of geographically distinct bacterial communities associated with coral mucus produced by Acropora spp. and Porites spp. Appl Environ Microbiol. 2012;78:5229-37 pubmed publisher
    Acropora and Porites corals are important reef builders in the Indo-Pacific and Caribbean. Bacteria associated with mucus produced by Porites spp. and Acropora spp...
  32. Zhu T, Zhang W, Wang D, Huang N, Bo H, Deng W, et al. Rosuvastatin attenuates mucus secretion in a murine model of chronic asthma by inhibiting the gamma-aminobutyric acid type A receptor. Chin Med J (Engl). 2012;125:1457-64 pubmed
    ..In this study, we investigated the effect of rosuvastatin on airway inflammation and its inhibitory mechanism in mucus hypersecretion in a murine model of chronic asthma.
  33. Jang S, Park J, Cha H, Jung S, Lee J, Jung S, et al. Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation. Int J Nanomedicine. 2012;7:1329-43 pubmed publisher
    ..The aim of this study was to investigate the effects of silver NPs on VEGF signaling pathways and mucus hypersecretion...
  34. Gustafsson J, Sjovall H, Hansson G. Ex vivo measurements of mucus secretion by colon explants. Methods Mol Biol. 2012;842:237-43 pubmed publisher
    An explant tissue system for the study and recording of mucus secretion has been developed...
  35. Wrzosek L, Miquel S, Noordine M, Bouet S, Joncquel Chevalier Curt M, Robert V, et al. Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent. BMC Biol. 2013;11:61 pubmed publisher
    The intestinal mucus layer plays a key role in the maintenance of host-microbiota homeostasis...
  36. Ouwerkerk J, de Vos W, Belzer C. Glycobiome: bacteria and mucus at the epithelial interface. Best Pract Res Clin Gastroenterol. 2013;27:25-38 pubmed publisher
    ..with a thin lining of host derived glycans, including the cell surface glycocalyx and the extracellular secreted mucus. The mucosa-associated microbial composition differs from the luminal content and could be particularly important ..
  37. Holmén Larsson J, Thomsson K, Rodríguez Piñeiro A, Karlsson H, Hansson G. Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution. Am J Physiol Gastrointest Liver Physiol. 2013;305:G357-63 pubmed publisher
    The mouse intestinal mucus is mainly made up by the gel-forming Muc2 mucin and the stomach surface mucus Muc5ac, both extensively O-glycosylated...
  38. Chakravorty I, Chahal K, Austin G. A pilot study of the impact of high-frequency chest wall oscillation in chronic obstructive pulmonary disease patients with mucus hypersecretion. Int J Chron Obstruct Pulmon Dis. 2011;6:693-9 pubmed publisher
    Chronic obstructive pulmonary disease (COPD) patients with mucus hypersecretion tend to demonstrate increased frequency of infective exacerbations and a steeper slope of decline in lung function...
  39. Hasnain S, McGuckin M, Grencis R, Thornton D. Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier. PLoS Negl Trop Dis. 2012;6:e1856 pubmed publisher
    The polymeric mucin component of the intestinal mucus barrier changes during nematode infection to provide not only physical protection but also to directly affect pathogenic nematodes and aid expulsion...
  40. Holm L, Phillipson M. Assessment of mucus thickness and production in situ. Methods Mol Biol. 2012;842:217-27 pubmed publisher
    The nature of the mucus gel layer covering the gastrointestinal tract makes it difficult to study outside its natural site attached to the mucosa...
  41. Reunanen J, von Ossowski I, Hendrickx A, Palva A, de Vos W. Characterization of the SpaCBA pilus fibers in the probiotic Lactobacillus rhamnosus GG. Appl Environ Microbiol. 2012;78:2337-44 pubmed publisher
    ..to be encoded by the spaCBA gene cluster, and the pilus-associated SpaC pilin was shown to confer on the cells a mucus-binding ability...
  42. Gersemann M, Becker S, Nuding S, Antoni L, Ott G, Fritz P, et al. Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD. J Crohns Colitis. 2012;6:425-34 pubmed publisher
    ..Olfactomedin-4 (OLFM4) is a glycoprotein characteristic of intestinal stem cells and apparently involved in mucosal defense of the stomach and colon. Here we studied its expression, regulation and function in IBD...
  43. Livraghi Butrico A, Kelly E, Klem E, Dang H, Wolfgang M, Boucher R, et al. Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation. Mucosal Immunol. 2012;5:397-408 pubmed publisher
    It has been postulated that mucus stasis is central to the pathogenesis of obstructive lung diseases...
  44. Alevy Y, Patel A, Romero A, Patel D, Tucker J, Roswit W, et al. IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. J Clin Invest. 2012;122:4555-68 pubmed publisher
    Increased mucus production is a common cause of morbidity and mortality in inflammatory airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis...
  45. Yang J, Yu H, Zhou X, Kolosov V, Perelman J. Study on TRPV1-mediated mechanism for the hypersecretion of mucus in respiratory inflammation. Mol Immunol. 2013;53:161-71 pubmed publisher
    ..is sensitized by the high affinity TrkA receptor, which promotes pro-inflammatory cytokine production and mediates mucus hypersecretion in bronchial epithelial cells...
  46. Barr J, Auro R, Furlan M, Whiteson K, Erb M, Pogliano J, et al. Bacteriophage adhering to mucus provide a non-host-derived immunity. Proc Natl Acad Sci U S A. 2013;110:10771-6 pubmed publisher
    ..Both bacteria and phage are associated with this mucus. Here we show that phage-to-bacteria ratios were increased, relative to the adjacent environment, on all mucosal ..
  47. Klein Júnior L, Santin J, Lemos M, Silveira A, Rocha J, Beber A, et al. Role of gastric mucus secretion, oxinitrergic system and sulfhydryl groups on the gastroprotection elicited by Polygala cyparissias (Polygalaceae) in mice. J Pharm Pharmacol. 2013;65:767-76 pubmed publisher
  48. Pales Espinosa E, Winnicki S, Allam B. Early host-pathogen interactions in a marine bivalve: Crassostrea virginica pallial mucus modulates Perkinsus marinus growth and virulence. Dis Aquat Organ. 2013;104:237-47 pubmed publisher
    ..Therefore, mucus covering these organs represents the first host effectors encountered by P. marinus...
  49. Landeira Dabarca A, Sieiro C, Alvarez M. Change in food ingestion induces rapid shifts in the diversity of microbiota associated with cutaneous mucus of Atlantic salmon Salmo salar. J Fish Biol. 2013;82:893-906 pubmed publisher
    ..This is the first report of an effect of feeding regime on the abundance of microbial communities associated with cutaneous mucus of fishes.
  50. Russo P, Stigliani M, Prota L, Auriemma G, Crescenzi C, Porta A, et al. Gentamicin and leucine inhalable powder: what about antipseudomonal activity and permeation through cystic fibrosis mucus?. Int J Pharm. 2013;440:250-5 pubmed publisher
    ..the permeation properties of gentamicin (G) in a novel dry powder form for inhalation through an artificial mucus model...
  51. Troge A, Scheppach W, Schroeder B, Rund S, Heuner K, Wehkamp J, et al. More than a marine propeller--the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus. Int J Med Microbiol. 2012;302:304-14 pubmed publisher
    ..These results and in vitro studies with different epithelial cells indicated that the presence of mucus is important for efficient mediation of adhesion by the flagellum of EcN...
  52. Wlodarska M, Thaiss C, Nowarski R, Henao Mejia J, Zhang J, Brown E, et al. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 2014;156:1045-59 pubmed publisher
    b>Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial protective mechanism at the interface between the eukaryotic and prokaryotic cells of the mammalian intestinal ecosystem...
  53. Gehrig S, Duerr J, Weitnauer M, Wagner C, Graeber S, Schatterny J, et al. Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease. Am J Respir Crit Care Med. 2014;189:1082-92 pubmed publisher
    ..However, the role of NE in the complex in vivo pathogenesis of CF lung disease remains poorly understood...