rutin

Summary

Summary: A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.

Top Publications

  1. Sánchez Gallego J, López Revuelta A, Sardina J, Hernández Hernández A, Sánchez Yagüe J, Llanillo M. Membrane cholesterol contents modify the protective effects of quercetin and rutin on integrity and cellular viability in oxidized erythrocytes. Free Radic Biol Med. 2010;48:1444-54 pubmed publisher
    ..We have previously proved that membrane cholesterol contents modify the protective power of quercetin and rutin against oxidative stress in erythrocytes...
  2. Sharma S, Ali A, Ali J, Sahni J, Baboota S. Rutin : therapeutic potential and recent advances in drug delivery. Expert Opin Investig Drugs. 2013;22:1063-79 pubmed publisher
    ..b>Rutin , a polyphenolic bioflavonoid has shown wide range of pharmacological applications due to its significant ..
  3. Tongjaroenbuangam W, Ruksee N, Chantiratikul P, Pakdeenarong N, Kongbuntad W, Govitrapong P. Neuroprotective effects of quercetin, rutin and okra (Abelmoschus esculentus Linn.) in dexamethasone-treated mice. Neurochem Int. 2011;59:677-85 pubmed publisher
    ..extract and its derivatives (quercetin and rutin) to protect neuronal function and improve learning and memory deficits in mice subjected to dexamethasone ..
  4. Al Rejaie S, Abuohashish H, Alkhamees O, Aleisa A, Alroujayee A. Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats. Lipids Health Dis. 2012;11:41 pubmed publisher
    ..b>Rutin and ascorbic acid showed a protective role against oxidative stress-mediated diseases...
  5. Wang S, Wang Y, Su Y, Zhou W, Yang S, Zhang R, et al. Rutin inhibits ?-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines. Neurotoxicology. 2012;33:482-90 pubmed publisher
    ..Here, we show that the common dietary flavonoid, rutin, can dose-dependently inhibit A?42 fibrillization and attenuate A?42-induced cytotoxicity in SH-SY5Y neuroblastoma ..
  6. Wu H, Chen M, Fan Y, Elsebaei F, Zhu Y. Determination of rutin and quercetin in Chinese herbal medicine by ionic liquid-based pressurized liquid extraction-liquid chromatography-chemiluminescence detection. Talanta. 2012;88:222-9 pubmed publisher
    ..liquid chromatography (HPLC) tandem chemiluminescence (CL) detection capable of quantifying trace amounts of rutin and quercetin in four Chinese medicine plants including Flos sophorae Immaturus, Crateagus pinnatifida Bunge, ..
  7. Araújo K, de M B Costa E, Pazini F, Valadares M, de Oliveira V. Bioconversion of quercetin and rutin and the cytotoxicity activities of the transformed products. Food Chem Toxicol. 2013;51:93-6 pubmed publisher
    Quercetin and rutin are well-know flavonoids. In spite of this, the comprehension of their metabolism is still incomplete...
  8. Hunyadi A, Martins A, Hsieh T, Seres A, Zupko I. Chlorogenic acid and rutin play a major role in the in vivo anti-diabetic activity of Morus alba leaf extract on type II diabetic rats. PLoS ONE. 2012;7:e50619 pubmed publisher
    ..of an extract of mulberry leaves (MA), and to examine to what extent three major constituents, chlorogenic acid, rutin and isoquercitrin, might contribute to the observed activity...
  9. Khan M, Ahmad A, Ishrat T, Khuwaja G, Srivastawa P, Khan M, et al. Rutin protects the neural damage induced by transient focal ischemia in rats. Brain Res. 2009;1292:123-35 pubmed publisher
    ..The present study was designed to assess the neuroprotective role of rutin (Vitamin P), and mechanism of action...

More Information

Publications69

  1. Isai M, Sakthivel M, Ramesh E, Thomas P, Geraldine P. Prevention of selenite-induced cataractogenesis by rutin in Wistar rats. Mol Vis. 2009;15:2570-7 pubmed
    To investigate whether rutin retards selenite-induced cataractogenesis in Wistar rat pups. On postpartum day ten, Group I rat pups received an intraperitoneal injection of saline...
  2. Abd El Fattah A, El Sawalhi M, Rashed E, El Ghazaly M. Possible role of vitamin E, coenzyme Q10 and rutin in protection against cerebral ischemia/reperfusion injury in irradiated rats. Int J Radiat Biol. 2010;86:1070-8 pubmed publisher
    To investigate the possible role of vitamin E, coenzyme Q10 and rutin in ameliorating the biochemical changes in brain and serum induced by cerebral ischemia/reperfusion (I/R) in whole body ?-irradiated rats...
  3. Nebbioso M, Belcaro G, Librando A, Rusciano D, Steigerwalt R, Pescosolido N. Forskolin and rutin prevent intraocular pressure spikes after Nd:YAG laser iridotomy. Panminerva Med. 2012;54:77-82 pubmed
    the purpose of this research was to evaluate whether an oral treatment with an association of forskolin and rutin can blunt the intraocular pressure (IOP) spikes and avoid the damage that may occur after laser iridotomy...
  4. Kim G, Jang H. Protective mechanism of quercetin and rutin using glutathione metabolism on HO-induced oxidative stress in HepG2 cells. Ann N Y Acad Sci. 2009;1171:530-7 pubmed publisher
    ..In contrast, the prolonged treatment of quercetin in high concentrations (100 micromol/L) shows that quercetin may act as a pro-oxidant rather than as an antioxidant, resulting in cell death (apoptosis). ..
  5. Gohlke A, Ingelmann C, Nurnberg G, Starke A, Wolffram S, Metges C. Bioavailability of quercetin from its aglycone and its glucorhamnoside rutin in lactating dairy cows after intraduodenal administration. J Dairy Sci. 2013;96:2303-2313 pubmed publisher
    ..27 mg of quercetin equivalents (QE)/kg of body weight] either as quercetin aglycone (QA) or as its glucorhamnoside rutin (RU). In addition, 2 control studies with duodenal administration of NaCl solution (0...
  6. Alonso Castro A, Dominguez F, Garcia Carranca A. Rutin exerts antitumor effects on nude mice bearing SW480 tumor. Arch Med Res. 2013;44:346-51 pubmed publisher
    ..and Croton lechleri exerted in vitro cytotoxic and in vivo antitumor effects and that their main component was rutin (RTN; 3-rhamnosyl-glucosylquercetin)...
  7. Florek E, Ignatowicz E, Piekoszewski W. Effect of pregnancy and tobacco smoke on the antioxidant activity of rutin in an animal model. Pharmacol Rep. 2009;61:935-40 pubmed
    ..The aim of the current study was to evaluate the effect of rutin on the total antioxidant status (TAS) in pregnant and non-pregnant rats that were exposed to cigarette smoke...
  8. Hsieh C, Peng C, Chen K, Peng R. Rutin (quercetin rutinoside) induced protein-energy malnutrition in chronic kidney disease, but quercetin acted beneficially. J Agric Food Chem. 2013;61:7258-67 pubmed publisher
    ..However, controversial reports are accumulating. We hypothesize that rutin (RT) and quercetin (QT) pharmacodynamically could act differently. To confirm this, doxorubicin (DR) (8...
  9. Hao H, Shao Z, Tang D, Lu Q, Chen X, Yin X, et al. Preventive effects of rutin on the development of experimental diabetic nephropathy in rats. Life Sci. 2012;91:959-67 pubmed publisher
    ..In this study, the preventive effect and mechanism of rutin on the development of DN in streptozotocin (STZ)-induced diabetic rats were investigated...
  10. Pandey A, Misra P, Chandrashekar K, Trivedi P. Development of AtMYB12-expressing transgenic tobacco callus culture for production of rutin with biopesticidal potential. Plant Cell Rep. 2012;31:1867-76 pubmed publisher
    ..a flavonol-specific transcription factor, AtMYB12, with an objective to use callus as an alternative source of rutin. Transgenic callus displayed enhanced expression of genes related to biosynthetic pathway leading to increased ..
  11. Bhandary B, Piao C, Kim D, Lee G, Chae S, Kim H, et al. The protective effect of rutin against ischemia/reperfusion-associated hemodynamic alteration through antioxidant activity. Arch Pharm Res. 2012;35:1091-7 pubmed publisher
    ..was designed to evaluate the preventive effects of various isoflavonoids such as biochanin A, daidzein, genistein, rutin and quercetin...
  12. Panchal S, Poudyal H, Arumugam T, Brown L. Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats. J Nutr. 2011;141:1062-9 pubmed publisher
    ..This study investigated preventive or reversal responses to rutin in high-carbohydrate, high-fat diet-fed rats as a model of metabolic syndrome...
  13. Nassiri Asl M, Naserpour Farivar T, Abbasi E, Sadeghnia H, Sheikhi M, Lotfizadeh M, et al. Effects of rutin on oxidative stress in mice with kainic acid-induced seizure. J Integr Med. 2013;11:337-42 pubmed publisher
    ..We assessed the effect of rutin (quercetin-3-O-rutinoside) on oxidative stress in kainic acid (KA)-induced seizure...
  14. Nassiri Asl M, Mortazavi S, Samiee Rad F, Zangivand A, Safdari F, Saroukhani S, et al. The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats. Epilepsy Behav. 2010;18:50-3 pubmed publisher
    ..Various synthetic derivatives of natural flavonoids are known to have neuroactive properties. Rutin is a flavonoid that is an important dietary constituent of foods and plant-based beverages...
  15. Gong G, Qin Y, Huang W, Zhou S, Yang X, Li D. Rutin inhibits hydrogen peroxide-induced apoptosis through regulating reactive oxygen species mediated mitochondrial dysfunction pathway in human umbilical vein endothelial cells. Eur J Pharmacol. 2010;628:27-35 pubmed publisher
    ..b>Rutin, an active flavonoid compound, is well known to possess potent antioxidant properties against oxidative stress ..
  16. Wagner C, Vargas A, Roos D, Morel A, Farina M, Nogueira C, et al. Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices. Arch Toxicol. 2010;84:89-97 pubmed publisher
    ..e., rutin and quercitrin) against MeHg toxicity were evaluated in rat cortical brain slices...
  17. Richetti S, Blank M, Capiotti K, Piato A, Bogo M, Vianna M, et al. Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish. Behav Brain Res. 2011;217:10-5 pubmed publisher
    ..The aim of our study was to investigate the potential protective role of quercetin and rutin against scopolamine-induced inhibitory avoidance memory deficits in zebrafish...
  18. Salvador M, Boiça A, de Oliveira M, da Graça J, da Silva D, Hoffmann Campo C. Do different casein concentrations increase the adverse effect of rutin on the biology of Anticarsia gemmatalis Hübner (Lepidoptera: Noctuidae)?. Neotrop Entomol. 2010;39:774-83 pubmed
    The flavonoid rutin is recognized as playing an important role in the protection of plants against lepidopterans. Bioassays with this compound are generally carried out using artificial diets...
  19. Domitrovic R, Jakovac H, Vasiljev Marchesi V, Vladimir Knežević S, Cvijanovic O, Tadić Z, et al. Differential hepatoprotective mechanisms of rutin and quercetin in CCl(4)-intoxicated BALB/cN mice. Acta Pharmacol Sin. 2012;33:1260-70 pubmed publisher
    To investigate the mechanisms underlying the protective effects of quercetin-rutinoside (rutin) and its aglycone quercetin against CCl(4)-induced liver damage in mice...
  20. Rabiskova M, Bautzová T, Gajdziok J, Dvorácková K, Lamprecht A, Pellequer Y, et al. Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: in vitro characteristics and in vivo evaluation. Int J Pharm. 2012;422:151-9 pubmed publisher
    Preparation of coated pellets intended for rutin colon delivery, their evaluation in vitro and in vivo in experimental colitis in rats was the purpose of this study...
  21. Yu C, Wu P, Hou Y, Lin S, Tsai S, Chen C, et al. Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4. J Agric Food Chem. 2011;59:4644-8 pubmed publisher
    Quercetin and rutin are popular flavonoids in plant foods, herbs, and dietary supplements...
  22. Hu Q, Wang C, Li J, Zhang D, Kong L. Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement. Am J Physiol Renal Physiol. 2009;297:F1080-91 pubmed publisher
    ..Lowering serum uric acid levels with allopurinol, rutin, and quercetin increased the urinary uric acid/creatinine ratio and FE(ur) and attenuated other fructose-induced ..
  23. Zhu Q. A novel chemiluminescent flow injection analysis of trace amounts of rutin by its inhibition of the luminol-hydrogen peroxide reaction catalyzed by tetrasulfonated colbalt phthalocyanine. Luminescence. 2009;24:250-4 pubmed publisher
    Based on the inhibition effect of rutin on the luminol-hydrogen peroxide chemiluminescence (CL) system catalyzed by tetrasulfonated colbalt phthalocyanine (CoTSPc), a sensitive flow-injection CL method has been developed for the ..
  24. Gao M, Ma Y, Liu D. Rutin suppresses palmitic acids-triggered inflammation in macrophages and blocks high fat diet-induced obesity and fatty liver in mice. Pharm Res. 2013;30:2940-50 pubmed publisher
    To elucidate the mechanism of rutin in blocking macrophage-mediated inflammation and high fat diet-induced obesity and fatty liver...
  25. Carrasco Pozo C, Mizgier M, Speisky H, Gotteland M. Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells. Chem Biol Interact. 2012;195:199-205 pubmed publisher
    ..The aim of this study was to evaluate the protective effects of dietary polyphenols quercetin, rutin, resveratrol and epigallocatechin gallate against the alterations of mitochondrial function induced by ..
  26. Zhao J, Lin D, Yao S. Adsorption of rutin with a novel ?-cyclodextrin polymer adsorbent: thermodynamic and kinetic study. Carbohydr Polym. 2012;90:1764-70 pubmed publisher
    The adsorption properties toward rutin of a cyclodextrin polymer adsorbent CroCD-TuC 3 have been studied. The adsorption capacity is reduced as temperature and pH of solution rises, but increases with the increase of solvent polarity...
  27. Gupta N, Sharma S, Rana J, Chauhan R. Expression of flavonoid biosynthesis genes vis-à-vis rutin content variation in different growth stages of Fagopyrum species. J Plant Physiol. 2011;168:2117-23 pubmed publisher
    Buckwheat is one of the field crops with the highest concentration of rutin, an important flavonoid of medicinal value. Two species of buckwheat, Fagopyrum esculentum and Fagopyrum tataricum, are the major sources of rutin...
  28. Nones J, Costa A, Leal R, Gomes F, Trentin A. The flavonoids hesperidin and rutin promote neural crest cell survival. Cell Tissue Res. 2012;350:305-15 pubmed publisher
    ..In the present work, we have investigated the actions of the flavonoids hesperidin, rutin and quercetin on NC cells of quail, in vitro...
  29. Wei S, Yan Z, Zhou J. Protective effect of rutin on testicular ischemia-reperfusion injury. J Pediatr Surg. 2011;46:1419-24 pubmed publisher
    ..This study aimed to investigate the effect of rutin, a well-known antioxidant, on testicular ischemia-reperfusion injury.
  30. Lapa F, Gadotti V, Missau F, Pizzolatti M, Marques M, Dafre A, et al. Antinociceptive properties of the hydroalcoholic extract and the flavonoid rutin obtained from Polygala paniculata L. in mice. Basic Clin Pharmacol Toxicol. 2009;104:306-15 pubmed publisher
    ..001-1.0 mg/kg orally) caused significant and dose-dependent inhibition of glutamate-induced pain. However, only rutin, but not phebalosin or aurapten, isolated from P...
  31. Jeong J, Ha Y, Jin Y, Lee E, Kim J, Kim H, et al. Rutin from Lonicera japonica inhibits myocardial ischemia/reperfusion-induced apoptosis in vivo and protects H9c2 cells against hydrogen peroxide-mediated injury via ERK1/2 and PI3K/Akt signals in vitro. Food Chem Toxicol. 2009;47:1569-76 pubmed publisher
    We investigated pharmacological effects of rutin isolated form Lonicera japonica on H2O2-induced cell death in H9c2 cells in vitro and rat myocardial ischemia-reperfusion injury model in vivo...
  32. Bourogaa E, Bertrand J, Despeaux M, Jarraya R, Fabre N, Payrastre L, et al. Hammada scoparia flavonoids and rutin kill adherent and chemoresistant leukemic cells. Leuk Res. 2011;35:1093-101 pubmed publisher
    ..We show that H. scoparia flavonoidic fraction and its compound rutin induce apoptosis specifically in adherent leukemic cells and abolish CAM-DR...
  33. Dimpfel W. Rat electropharmacograms of the flavonoids rutin and quercetin in comparison to those of moclobemide and clinically used reference drugs suggest antidepressive and/or neuroprotective action. Phytomedicine. 2009;16:287-94 pubmed publisher
    ..The present investigation aims at the prediction of efficacy and possible mechanisms of action of rutin and quercetin...
  34. Wu C, Lin M, Wang H, Yang M, Jou M, Wang C. Rutin inhibits oleic acid induced lipid accumulation via reducing lipogenesis and oxidative stress in hepatocarcinoma cells. J Food Sci. 2011;76:T65-72 pubmed publisher
    ..b>Rutin, a common dietary flavonoid that is consumed in fruits, vegetables, and plant-derived beverages, has various ..
  35. Challa S, Akula A, Metla S, Gopal P. Partial role of nitric oxide in infarct size limiting effect of quercetin and rutin against ischemia-reperfusion injury in normal and diabetic rats. Indian J Exp Biol. 2011;49:207-10 pubmed
    ..The present communication report the involvement of nitric oxide (NO) in cardioprotection offered by flavonoids (rutin and quercetin) against myocardial ischemia reperfusion...
  36. Annapurna A, Ansari M, Manjunath P. Partial role of multiple pathways in infarct size limiting effect of quercetin and rutin against cerebral ischemia-reperfusion injury in rats. Eur Rev Med Pharmacol Sci. 2013;17:491-500 pubmed
    ..Both experimental and epidemiological evidence demonstrate that bioflavonoid such as quercetin and rutin are neuroprotective in models of cerebral ischemia reperfusion injury...
  37. Franzoi A, Migowski P, Dupont J, Vieira I. Development of biosensors containing laccase and imidazolium bis(trifluoromethylsulfonyl)imide ionic liquid for the determination of rutin. Anal Chim Acta. 2009;639:90-5 pubmed publisher
    ..TDMI x Tf(2)N), along with laccase from Aspergillus oryzae, were constructed and optimized for determination of rutin. The laccase catalyzes the oxidation of rutin to the corresponding o-quinone, which is electrochemically reduced ..
  38. Cai E, Lin J. Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells. J Agric Food Chem. 2009;57:9817-27 pubmed publisher
    ..In this study, the tea polyphenol EGCG (epigallocatechin gallate) and the buckwheat flavonoid Rutin were investigated to attenuate the induced glucotoxicity in beta cells...
  39. Song W, Wang H, Bucheli P, Zhang P, Wei D, Lu Y. Phytochemical profiles of different mulberry (Morus sp.) species from China. J Agric Food Chem. 2009;57:9133-40 pubmed publisher
    ..resveratrol, oxyresveratrol, cyanidin-3-O-beta-glucoside (Cy-3-glu), cyanidin-3-O-beta-rutinoside (Cy-3-rut), and rutin in mulberry juice, fruits, and leaves of 8 species grown in China were examined...
  40. Dawidowicz A, Wianowska D. Application of the MSPD technique for the HPLC analysis of rutin in Sambucus nigra L.: the linear correlation of the matrix solid-phase dispersion process. J Chromatogr Sci. 2009;47:914-8 pubmed
    ..This idea has been developed for analysis of rutin amount in Sambucus nigra L. (elderberry)...
  41. Punithavathi V, Shanmugapriya K, Prince P. Protective effects of rutin on mitochondrial damage in isoproterenol-induced cardiotoxic rats: an in vivo and in vitro study. Cardiovasc Toxicol. 2010;10:181-9 pubmed publisher
    ..Pretreatment with rutin at the dose of 80 mg/kg daily for 42 days to isoproterenol-induced rats prevented all the biochemical alterations...
  42. Pashikanti S, de Alba D, Boissonneault G, Cervantes Laurean D. Rutin metabolites: novel inhibitors of nonoxidative advanced glycation end products. Free Radic Biol Med. 2010;48:656-63 pubmed publisher
    ..b>Rutin derivatives were tested as AGE inhibitors because rutin, a common dietary flavonoid that is consumed in fruits, ..
  43. Hu Q, Zhang X, Pan Y, Li Y, Kong L. Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats. Biochem Pharmacol. 2012;84:113-25 pubmed publisher
    ..The restoration of fructose-induced hyperuricemia and dyslipidemia by the treatment of allopurinol, quercetin and rutin blocked the NLRP3 inflammasome activation to improve the signaling impairments and reduce lipid accumulation in ..
  44. Kuntić V, Filipovic I, Vujić Z. Effects of rutin and hesperidin and their Al(III) and Cu(II) complexes on in vitro plasma coagulation assays. Molecules. 2011;16:1378-88 pubmed publisher
    Two flavonoids, rutin and hesperidin, were investigated in vitro for anticoagulant activity through coagulation tests: activated partial thromboplastin time (aPTT), prothrombin time (PT) and thrombin time (TT)...
  45. Li Y, Zhou F, Gao F, Bian J, Shan F. Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of alpha-glucosidase. J Agric Food Chem. 2009;57:11463-8 pubmed publisher
    Three flavonoids from tartary buckwheat bran, namely, quercetin (Que), isoquercetin (Iso) and rutin (Rut), have been evaluated as alpha-glucosidase inhibitors by fluorescence spectroscopy and enzymatic kinetics and have also been ..
  46. Korkmaz A, Kolankaya D. Protective effect of rutin on the ischemia/reperfusion induced damage in rat kidney. J Surg Res. 2010;164:309-15 pubmed publisher
    ..This study was designed to investigate the effect of rutin, a bioflavonoid, in I/R induced renal injury...
  47. Peng L, Wang Y, Zeng H, Yuan Y. Molecularly imprinted polymer for solid-phase extraction of rutin in complicated traditional Chinese medicines. Analyst. 2011;136:756-63 pubmed publisher
    ..were prepared based on bulk polymerization by water-bath heating and ultrasonic elution of the template, using rutin as the template, acrylamide (AM) as the functional monomer and 2,2'-azobisisobutyronitrile (AIBN) as the cross ..
  48. Krukoski D, Comar S, Claro L, Leonart M, do Nascimento A. Effect of vitamin C, deferoxamine, quercetin and rutin against tert-butyl hydroperoxide oxidative damage in human erythrocytes. Hematology. 2009;14:168-72 pubmed publisher
    ..C), deferroxamine (DFO) and the flavonoids quercetin and rutin in normal human erythrocytes, submitted to in vitro oxidative stress induced by tert-butylhydroperoxide ((t)BHP)...
  49. Khan R, Khan M, Sahreen S. CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat. BMC Complement Altern Med. 2012;12:178 pubmed publisher
    b>Rutin is a polyphenolic natural flavonoid which possesses antioxidant and anticancer activity. In the present study the hepatoprotective effect of rutin was evaluated against carbon tetrachloride (CCl?)-induced liver injuries in rats...
  50. Si Y, Yin S, Oh S, Wang Z, Ye S, Yan L, et al. An integrated study of tyrosinase inhibition by rutin: progress using a computational simulation. J Biomol Struct Dyn. 2012;29:999-1012 pubmed
    ..1 kcal/mol) and performed a molecular dynamics simulation to verify docking results between tyrosinase and rutin. The docking results suggest that rutin mostly interacts with histidine residues located in the active site...
  51. Annapurna A, Reddy C, Akondi R, Rao S. Cardioprotective actions of two bioflavonoids, quercetin and rutin, in experimental myocardial infarction in both normal and streptozotocin-induced type I diabetic rats. J Pharm Pharmacol. 2009;61:1365-74 pubmed publisher
    ..We attempted to evaluate the cardioprotective actions of quercetin and rutin in ischaemia-reperfusion-induced myocardial infarction in both normal and diabetic rats...
  52. Arjumand W, Seth A, Sultana S. Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NF?B, TNF-? and caspase-3 expression in wistar rats. Food Chem Toxicol. 2011;49:2013-21 pubmed publisher
    ..In the present study the wistar rats were subjected to concurrent prophylactic oral treatment of rutin (75 and 150 mg/kgb.wt...
  53. Zeng H, Wang Y, Liu X, Kong J, Nie C. Preparation of molecular imprinted polymers using bi-functional monomer and bi-crosslinker for solid-phase extraction of rutin. Talanta. 2012;93:172-81 pubmed publisher
    Molecular imprinted polymers (MIPs) were prepared using rutin as the template, different reagents as the functional monomer and different reagents as the cross-linker by solution polymerization...
  54. Jiménez Aliaga K, Bermejo Bescós P, Benedi J, Martin Aragon S. Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells. Life Sci. 2011;89:939-45 pubmed publisher
    Quercetin and rutin have been reported to exert numerous pharmacological activities, such as free-radical scavenging, effects on immune and inflammatory cell functions, and could have benefits in Alzheimer's disease (AD) by mitigating ..
  55. Deng P, Xu Z, Li J. Simultaneous determination of ascorbic acid and rutin in pharmaceutical preparations with electrochemical method based on multi-walled carbon nanotubes-chitosan composite film modified electrode. J Pharm Biomed Anal. 2013;76:234-42 pubmed publisher
    In this paper, the simultaneous voltammetric determination of ascorbic acid (AA) and rutin (Ru) has been achieved at an acetylene black paste electrode modified with multi-walled carbon nanotubes-chitosan composite film (denoted as ..
  56. Araujo J, Goncalves P, Martel F. Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Nutr Res. 2011;31:77-87 pubmed publisher
    ..The aim of this review is to summarize the main chemopreventive properties of some polyphenols (quercetin, rutin, myricetin, chrysin, epigallocatechin-3-gallate, epicatechin, catechin, resveratrol, and xanthohumol) against CRC, ..
  57. Berger L, Wein S, Blank R, Metges C, Wolffram S. Bioavailability of the flavonol quercetin in cows after intraruminal application of quercetin aglycone and rutin. J Dairy Sci. 2012;95:5047-5055 pubmed publisher
    ..was administered intraruminally in equimolar amounts, either in the aglycone form or as its glucorhamnoside rutin, each at 2 dosages [10 and 50 mg of quercetin/kg of body weight (BW)]. In a second trial, 0...
  58. Ali M, Mudagal M, Goli D. Cardioprotective effect of tetrahydrocurcumin and rutin on lipid peroxides and antioxidants in experimentally induced myocardial infarction in rats. Pharmazie. 2009;64:132-6 pubmed
    The present study was undertaken to evaluate the cardioprotective potential of tetrahydrocurcumin (THC) and rutin in an in vivo rat ischemia-reperfusion (I/R) model of myocardial infarction (MI)...
  59. Lin Y, Chang Y, Hsiao N, Hsieh J, Wang C, Kung S, et al. Fisetin and rutin as 3C protease inhibitors of enterovirus A71. J Virol Methods. 2012;182:93-8 pubmed publisher
    ..An in vitro inhibitor screening assay using recombinant EV-A71 3C protease (3Cpro) demonstrated fisetin and rutin inhibiting 3Cpro enzymatic activity in a dose-dependent manner...
  60. Uzan E, Portet B, Lubrano C, Milesi S, Favel A, Lesage Meessen L, et al. Pycnoporus laccase-mediated bioconversion of rutin to oligomers suitable for biotechnology applications. Appl Microbiol Biotechnol. 2011;90:97-105 pubmed publisher
    ..with the commercial Suberase® as reference, for their ability to synthesise natural active oligomers from rutin (quercetin-3-rutinoside, one of the best-known naturally occurring flavonoid glycosides)...