Summary: A large class of organic compounds having more than one PHENOL group.

Top Publications

  1. Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev. 1998;56:317-33 pubmed
    b>Polyphenols constitute one of the most numerous and ubiquitous groups of plant metabolites and are an integral part of both human and animal diets...
  2. De Santiago E, Domínguez Fernández M, Cid C, De Peña M. Impact of cooking process on nutritional composition and antioxidants of cactus cladodes (Opuntia ficus-indica). Food Chem. 2018;240:1055-1062 pubmed publisher
    ..Principal Component Analysis distributed heat treated cactus cladodes according to their distinctive polyphenols and antioxidant capacity.
  3. Gu W, Yin H, Liu Y, Gou X. [The mechanism underlying the effects of tea polyphenol on epirubicin-induced autophagy and apoptosis in T24 bladder cancer cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:772-777 pubmed
    ..Conclusion TP inhibits autophagy through JNK pathway to enhance EPI-induced apoptosis in T24 bladder cancer cell line. ..
  4. Parameswari R, Rao K, Manigandan P, Vickram A, Archana A, Sridharan T. Tea polyphenol-T. arjuna bark as sperm antioxidant extender in infertile smokers. Cryo Letters. 2017;38:95-99 pubmed
    ..The motility and morphology of sperm cells were maintained better in E4 extender, and DNA damage is reduced. Extender recipe with natural antioxidants (E3 and E4) was found to be apt for infertile semen preservation. ..
  5. Velander P, Wu L, Henderson F, Zhang S, Bevan D, Xu B. Natural product-based amyloid inhibitors. Biochem Pharmacol. 2017;139:40-55 pubmed publisher
    ..To enhance natural product bioavailability in vivo, emerging work using nanocarriers for delivery has also been described. Finally, issues and challenges as well as future development of such inhibitors are envisioned. ..
  6. Cabrera Bañegil M, Schaide T, Manzano R, Delgado Adámez J, Durán Merás I, Martín Vertedor D. Optimization and validation of a rapid liquid chromatography method for determination of the main polyphenolic compounds in table olives and in olive paste. Food Chem. 2017;233:164-173 pubmed publisher
    ..Chromatographic separation of 26 polyphenols from different families was optimized. This method provides high linearity, in all cases higher than 98...
  7. Perusko M, Al Hanish A, Mihailovic J, Minic S, Trifunovic S, Prodic I, et al. Antioxidative capacity and binding affinity of the complex of green tea catechin and beta-lactoglobulin glycated by the Maillard reaction. Food Chem. 2017;232:744-752 pubmed publisher
    ..The effects of glycation of proteins via Maillard reaction on the binding capacity for polyphenols and the antiradical properties of the formed complexes have not been studied previously...
  8. Szejk M, Poplawski T, Czubatka Bieńkowska A, Olejnik A, Pawlaczyk Graja I, Gancarz R, et al. A comparative study on the radioprotective potential of the polyphenolic glycoconjugates from medicinal plants of Rosaceae and Asteraceae families versus their aglycones. J Photochem Photobiol B. 2017;171:50-57 pubmed publisher
    ..In addition, they possess many advantages, compared to the synthetic polyphenolic compounds or the plant extracts, such as water-solubility and minor toxicity. ..
  9. Afsar T, Razak S, Batoo K, Khan M. Acacia hydaspica R. Parker prevents doxorubicin-induced cardiac injury by attenuation of oxidative stress and structural Cardiomyocyte alterations in rats. BMC Complement Altern Med. 2017;17:554 pubmed publisher
    ..The protective effect might attribute to its polyphenolic constituents and antioxidant properties. AHE might be helpful in combination therapies as safer and efficient. ..

More Information


  1. Thouri A, Chahdoura H, El Arem A, Omri Hichri A, Ben Hassin R, Achour L. Effect of solvents extraction on phytochemical components and biological activities of Tunisian date seeds (var. Korkobbi and Arechti). BMC Complement Altern Med. 2017;17:248 pubmed publisher
    The interest in natural antioxidants, especially polyphenols, is growing more and more thanks to their positive contribution to human health...
  2. Wu P, Huang C, Chu Y, Huang Y, Lin P, Liu Y, et al. Alleviation of Ultraviolet B-Induced Photodamage by Coffea arabica Extract in Human Skin Fibroblasts and Hairless Mouse Skin. Int J Mol Sci. 2017;18: pubmed publisher
    ..The results indicated that CAE exhibits antiphotodamage activity by inhibiting UV-induced oxidative stress and inflammation. Therefore, CAE is a candidate for use in antioxidant, antiinflammatory, and antiphotodamage products. ..
  3. Commisso M, Bianconi M, Di Carlo F, Poletti S, Bulgarini A, Munari F, et al. Multi-approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar-dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry (Prunus avium L.). PLoS ONE. 2017;12:e0180889 pubmed publisher
    ..Our data therefore indicate that the total antioxidant activity of sweet cherry fruits may originate from cultivar-dependent interactions among different classes of metabolite. ..
  4. Zagayko A, Kravchenko G, Fylymonenko V, Krasilnikova O. Effect of apple polyphenol concentrate on lipid metabolism in rats under experimental insulin resistance. Wiad Lek. 2017;70:200-204 pubmed
    ..Total apple polyphenol food concentrate had a more pronounced effect on studied indices that is probably due to synergism and additive effect of extract numerous components. ..
  5. Desta K, Kim G, Abd El Aty A, Raha S, Kim M, Jeong J, et al. Flavone polyphenols dominate in Thymus schimperi Ronniger: LC-ESI-MS/MS characterization and study of anti-proliferative effects of plant extract on AGS and HepG2 cancer cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1053:1-8 pubmed publisher
    ..schimperi being characterized using HPLC-ESI-MS/MS. Being components of many edible vegetables, fruits, and spices, the identified polyphenols suggest that T. schimperi could be a potential food with promising health benefits.
  6. Lopes G, Schulman H, Hermes Lima M. Polyphenol tannic acid inhibits hydroxyl radical formation from Fenton reaction by complexing ferrous ions. Biochim Biophys Acta. 1999;1472:142-52 pubmed
    ..The antimutagenic and anticarcinogenic activity of TA, described elsewhere, may be explained (at least in part) by its capacity to prevent Fenton reactions. ..
  7. Pereira Caro G, Polyviou T, Ludwig I, Nastase A, Moreno Rojas J, Garcia A, et al. Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes. Am J Clin Nutr. 2017;106:791-800 pubmed publisher
    ..This trial was registered at clinicaltrials.gov as NCT02627547. ..
  8. Sytar O, Borankulova A, Hemmerich I, Rauh C, Smetanska I. Effect of chlorocholine chlorid on phenolic acids accumulation and polyphenols formation of buckwheat plants. Biol Res. 2014;47:19 pubmed publisher
    Effect of chlorocholine chloride (CCC) on phenolic acids composition and polyphenols accumulation in various anatomical parts (stems, leaves and inflorescences) of common buckwheat (Fagopyrum esculentum Moench) in the early stages of ..
  9. Haseeb S, Alexander B, Baranchuk A. Wine and Cardiovascular Health: A Comprehensive Review. Circulation. 2017;136:1434-1448 pubmed publisher
    ..On the basis of published work, we describe the composition of wine and the effects of constituent polyphenols on chronic cardiovascular diseases.
  10. Boncler M, Golanski J, Lukasiak M, Redzynia M, Dastych J, Watala C. A new approach for the assessment of the toxicity of polyphenol-rich compounds with the use of high content screening analysis. PLoS ONE. 2017;12:e0180022 pubmed publisher
    ..This approach should be recommended for series of compounds producing a non-sigmoidal cell response, and for agents with unknown toxicity or mechanisms of action. ..
  11. Vazquez Gomez M, Garcia Contreras C, Torres Rovira L, Pesantez J, Gonzalez Añover P, Gomez Fidalgo E, et al. Polyphenols and IUGR pregnancies: Maternal hydroxytyrosol supplementation improves prenatal and early-postnatal growth and metabolism of the offspring. PLoS ONE. 2017;12:e0177593 pubmed publisher
    ..These results suggest that maternal supplementation with hydroxytyrosol may improve pre- and early post-natal development of offspring in pregnancies at risk of IUGR. ..
  12. Hallmann E, Kazimierczak R, Marszałek K, Drela N, Kiernozek E, Toomik P, et al. The Nutritive Value of Organic and Conventional White Cabbage (Brassica Oleracea L. Var. Capitata) and Anti-Apoptotic Activity in Gastric Adenocarcinoma Cells of Sauerkraut Juice Produced Therof. J Agric Food Chem. 2017;65:8171-8183 pubmed publisher
    ..contains considerable amounts of bioactive compounds such as glucosinolates, vitamin C, carotenoids, and polyphenols. Some experiments indicate that vegetables from organic production contain more bioactive compounds than those ..
  13. Hassan S, Svajdlenka E, Berchová Bímová K. Hibiscus sabdariffa L. and Its Bioactive Constituents Exhibit Antiviral Activity against HSV-2 and Anti-enzymatic Properties against Urease by an ESI-MS Based Assay. Molecules. 2017;22: pubmed publisher
    ..Our results present Hibiscus sabdariffa L. and its bioactive compound PCA as potential therapeutic agents in the treatment of HSV-2 infection and the treatment of diseases caused by urease-producing bacteria. ..
  14. Peron G, Sut S, Pellizzaro A, Brun P, Voinovich D, Castagliuolo I, et al. The antiadhesive activity of cranberry phytocomplex studied by metabolomics: Intestinal PAC-A metabolites but not intact PAC-A are identified as markers in active urines against uropathogenic Escherichia coli. Fitoterapia. 2017;122:67-75 pubmed publisher
    ..On the other hand, significant metabolites that were detected are mainly metabolites of intestinal action on polyphenols and PACs, as well as glucuronidated and sulphated quercetin, suggesting an important role of intestinal ..
  15. Zhu W, Chen S, Chen R, Peng Z, Wan J, Wu B. Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats. BMC Complement Altern Med. 2017;17:455 pubmed publisher
    ..In this study, we explored the effects of taurine, tea polyphenols (TPs), or a combination thereof, on NASH rats...
  16. Affes M, Fakhfakh J, Daoud I, Brieudes V, Halabalaki M, El Feki A, et al. UHPLC/HR-ESI-MS/MS Profiling of Phenolics from Tunisian Lycium arabicum Boiss. Antioxidant and Anti-lipase Activities' Evaluation. Chem Biodivers. 2017;14: pubmed publisher
    ..These results showed that the MeOH extracts of stems and leaves of L. arabicum can be considered as a potential source of biological active compounds. ..
  17. Teugwa C, Mejiato P, Zofou D, Tchinda B, Boyom F. Antioxidant and antidiabetic profiles of two African medicinal plants: Picralima nitida (Apocynaceae) and Sonchus oleraceus (Asteraceae). BMC Complement Altern Med. 2013;13:175 pubmed publisher
    ..The present study aims at evaluating the antioxidant and antidiabetic potential of methanol and hydroethanol extracts of the stem bark and leaves of Pricralima nitida and the Sonchus oleraceus whole plant respectively...
  18. Heyman L, Houri Haddad Y, Heyman S, Ginsburg I, Gleitman Y, Feuerstein O. Combined antioxidant effects of Neem extract, bacteria, red blood cells and Lysozyme: possible relation to periodontal disease. BMC Complement Altern Med. 2017;17:399 pubmed publisher
    ..Neem leaf extract, containing polyphenols that adhere to oral surfaces, have the potential to provide long-lasting antibacterial as well as synergic ..
  19. Tafesse T, Hymete A, Mekonnen Y, Tadesse M. Antidiabetic activity and phytochemical screening of extracts of the leaves of Ajuga remota Benth on alloxan-induced diabetic mice. BMC Complement Altern Med. 2017;17:243 pubmed publisher
    ..remota extracts in reducing blood glucose levels presumably due to the presence of antioxidant constituents such as flavonoids. The effect of the extract supported the traditional claim of the plant. ..
  20. Liu S, Ai Z, Qu F, Chen Y, Ni D. Effect of steeping temperature on antioxidant and inhibitory activities of green tea extracts against ?-amylase, ?-glucosidase and intestinal glucose uptake. Food Chem. 2017;234:168-173 pubmed publisher
    ..Green tea steeped at 60°C had significantly stronger glucose uptake inhibitory activity (p<0.05). The integrated data suggested that steeping temperature should be considered when evaluating the biological activities of green tea. ..
  21. Zheng C, Liu R, Xue B, Luo J, Gao L, Wang Y, et al. Impact and consequences of polyphenols and fructooligosaccharide interplay on gut microbiota in rats. Food Funct. 2017;8:1925-1932 pubmed publisher
    Both fructooligosaccharide (FOS) and polyphenols can be individually and directly transferred to the large intestine of mammals and are beneficial for human health as they reshape the composition of gut microbiota...
  22. Watychowicz K, Janda K, Jakubczyk K, Wolska J. Chaenomeles – health promoting benefits. Rocz Panstw Zakl Hig. 2017;68:217-227 pubmed
    ..The aim of this review was to summarize the information and data on the chemical composition and therapeutic properties of Chaenomeles. ..
  23. Fiesel A, Gessner D, Most E, Eder K. Effects of dietary polyphenol-rich plant products from grape or hop on pro-inflammatory gene expression in the intestine, nutrient digestibility and faecal microbiota of weaned pigs. BMC Vet Res. 2014;10:196 pubmed publisher
    ..05). The present study suggests that dietary plant products rich in polyphenols are able to improve the gain:feed ratio in growing pigs...
  24. Li Y, Li L, Cui Y, Zhang S, Sun B. Separation and purification of polyphenols from red wine extracts using high speed counter current chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1054:105-113 pubmed publisher
    b>Polyphenols are important compounds of red wine owing to their contribution to sensory properties and antioxidant activities...
  25. Luna Vital D, Li Q, West L, West M, Gonzalez de Mejia E. Anthocyanin condensed forms do not affect color or chemical stability of purple corn pericarp extracts stored under different pHs. Food Chem. 2017;232:639-647 pubmed publisher
    ..8 to 3weeks), compared to pH 2 (44.6 to 60.7weeks). Condensed forms had degradation kinetics similar to monomeric anthocyanins. Purple corn pericarp pigments can be used in acid beverages with an acceptable shelf-life. ..
  26. Martinez Gonzalez A, Díaz Sánchez A, Rosa L, Vargas Requena C, Bustos Jaimes I, Alvarez Parrilla A. Polyphenolic Compounds and Digestive Enzymes: In Vitro Non-Covalent Interactions. Molecules. 2017;22: pubmed publisher
    ..Existing studies conducted in vitro allow one to elucidate the characteristics of the structure-function relationships, where differences between the structures of PCs might be the reason for different in vivo effects. ..
  27. Losada Barreiro S, Bravo Diaz C. Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases. Eur J Med Chem. 2017;133:379-402 pubmed publisher
    ..Recent strategies explore chemical modifications of the hydrophobicity of potent, natural antioxidants to improve their efficiency by fine-tuning their concentrations at the reaction site. ..
  28. Boehm K, Borrelli F, Ernst E, Habacher G, Hung S, Milazzo S, et al. Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database Syst Rev. 2009;:CD005004 pubmed publisher
    ..If not exceeding the daily recommended allowance, those who enjoy a cup of green tea should continue its consumption. Drinking green tea appears to be safe at moderate, regular and habitual use. ..
  29. Yamakawa M, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H, et al. Anthocyanin suppresses the toxicity of A? deposits through diversion of molecular forms in in vitro and in vivo models of Alzheimer's disease. Nutr Neurosci. 2016;19:32-42 pubmed publisher
    ..of the amyloid beta (A?1-42) peptide in fibrillar form, and many studies have shown that plant-derived polyphenols are capable of attenuating AD progression in various disease models...
  30. Clementino M, Shi X, Zhang Z. Prevention of Polyphenols Against Carcinogenesis Induced by Environmental Carcinogens. J Environ Pathol Toxicol Oncol. 2017;36:87-98 pubmed publisher
    ..Of all cancers, 19% are attributed to exposure to environmental chemical carcinogens. Dietary polyphenols from teas, vegetables, fruits, and many others exhibit multiple activities against cancers...
  31. Correia R, Grace M, Esposito D, Lila M. Wild blueberry polyphenol-protein food ingredients produced by three drying methods: Comparative physico-chemical properties, phytochemical content, and stability during storage. Food Chem. 2017;235:76-85 pubmed publisher
    ..Spray dried matrices produced with soy protein isolate had the highest concentration of polyphenols (156.2mg GAE/g) and anthocyanins (13.4mg/g) and the most potent DPPH scavenging activity (714.1?molesTE/g)...
  32. Sun X, Ma T, Han L, Huang W, Zhan J. Effects of Copper Pollution on the Phenolic Compound Content, Color, and Antioxidant Activity of Wine. Molecules. 2017;22: pubmed publisher
    ..At low copper concentrations, the concentrations of nearly all polyphenols increased, and the antioxidant activity values of the wine also increased...
  33. Jiang Q, Li X, Tian Y, Lin Q, Xie H, Lu W, et al. Lyophilized aqueous extracts of Mori Fructus and Mori Ramulus protect Mesenchymal stem cells from •OH-treated damage: bioassay and antioxidant mechanism. BMC Complement Altern Med. 2017;17:242 pubmed publisher
    ..By comparison, two non-flavonoids with catechol moiety produce only a weak single peak. ..
  34. Margalef M, Pons Z, Iglesias Carres L, Bravo F, Muguerza B, Arola Arnal A. Flavanol plasma bioavailability is affected by metabolic syndrome in rats. Food Chem. 2017;231:287-294 pubmed publisher
    ..In conclusion, this study demonstrated that MeS pathological state modified flavanol bioavailability, supporting the hypothesis that flavanol metabolism, and therefore flavanol functionality, depend on the organism's state of health. ..
  35. Chen T, Li Y, Zhang L. Nine Different Chemical Species and Action Mechanisms of Pancreatic Lipase Ligands Screened Out from Forsythia suspensa Leaves All at One Time. Molecules. 2017;22: pubmed publisher
    ..suspensa leaves for the first time, IC50 notably reached 2.9 ± 0.5 μmol/L), two polyphenols (chlorogenic acid, 3150 ± 120 μmol/L; caffeic acid, 1394 ± 52 μmol/L), two lignans (phillyrin, promoter; ..
  36. Garcia Villalba R, Vissenaekens H, Pitart J, Romo Vaquero M, Espín J, Grootaert C, et al. Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract. J Agric Food Chem. 2017;65:5480-5493 pubmed publisher
    A TWIN-SHIME system was used to compare the metabolism of pomegranate polyphenols by the gut microbiota from two individuals with different urolithin metabotypes...
  37. Konaté K, Zerbo P, Ouedraogo M, Dibala C, Adama H, Sytar O, et al. Anti-nociceptive properties in rodents and the possibility of using polyphenol-rich fractions from sida urens L. (Malvaceae) against of dental caries bacteria. Ann Clin Microbiol Antimicrob. 2013;12:14 pubmed publisher
    ..Malvaceae) and demonstrate the potential of this herbaceous as a potential antibacterial agent of dental caries that could be effectively used for future health care purposes. ..
  38. Rahman I, Chung S. Dietary polyphenols, deacetylases and chromatin remodeling in inflammation. World Rev Nutr Diet. 2010;101:84-94 pubmed publisher
  39. Li C, Suzuki K, Hung Y, Yang M, Yu C, Lin S, et al. Aloe Metabolites Prevent LPS-Induced Sepsis and Inflammatory Response by Inhibiting Mitogen-Activated Protein Kinase Activation. Am J Chin Med. 2017;45:847-861 pubmed publisher
    ..Therefore, aloe could be considered an effective therapeutic agent for the treatment of sepsis. ..
  40. Liu K, Pi F, Zhang H, Ji J, Xia S, Cui F, et al. Metabolomics Analysis To Evaluate the Anti-Inflammatory Effects of Polyphenols: Glabridin Reversed Metabolism Change Caused by LPS in RAW 264.7 Cells. J Agric Food Chem. 2017;65:6070-6079 pubmed publisher
    ..Metabolic pathway analysis can be an effective tool to elucidate the mechanism of inflammation and to potentially find new anti-inflammatory agents. ..
  41. Li X, Jiang X, Sun J, Zhu C, Li X, Tian L, et al. Cytoprotective effects of dietary flavonoids against cadmium-induced toxicity. Ann N Y Acad Sci. 2017;1398:5-19 pubmed publisher
    ..In particular, a better understanding is needed of the structure-activity relationship of flavonoids against Cd toxicity, which has not yet been reported. ..
  42. Alqurashi R, Alarifi S, Walton G, Costabile A, Rowland I, Commane D. In vitro approaches to assess the effects of açai (Euterpe oleracea) digestion on polyphenol availability and the subsequent impact on the faecal microbiota. Food Chem. 2017;234:190-198 pubmed publisher
    A considerable proportion of dietary plant-polyphenols reach the colon intact; determining the effects of these compounds on colon-health is of interest...
  43. Mateos R, Baeza G, Sarria B, Bravo L. Improved LC-MSn characterization of hydroxycinnamic acid derivatives and flavonols in different commercial mate (Ilex paraguariensis) brands. Quantification of polyphenols, methylxanthines, and antioxidant activity. Food Chem. 2018;241:232-241 pubmed publisher
    Yerba mate is a beverage rich in bioactive compounds popular in South America. Polyphenols and methylxanthines were qualitatively and quantitatively analyzed in four commercial brands of yerba mate, as well as the antioxidant capacity of ..
  44. Guffa B, Nedić N, Dabić Zagorac D, Tosti T, Gašić U, Natić M, et al. Characterization of Sugar and Polyphenolic Diversity in Floral Nectar of Different 'Obla?inska' Sour Cherry Clones. Chem Biodivers. 2017;14: pubmed publisher
    ..Eleven polyphenols were quantified using available standards, while another 17 were identified according to their exact masses and ..
  45. Xiong Y. Inhibition of hazardous compound formation in muscle foods by antioxidative phytophenols. Ann N Y Acad Sci. 2017;1398:37-46 pubmed publisher
    ..nature, phenolic acids and flavonoids, such as tea catechins, caffeic acid, chlorogenic acid, and mixed polyphenols derived from rosemary, licorice, and other herbal materials, are capable of inhibiting the formation of harmful ..
  46. Tarko T, Duda Chodak A, Semik Szczurak D. The use of fruit extracts for production of apple chips with enhanced antioxidant activity. Rocz Panstw Zakl Hig. 2017;68:161-165 pubmed
    ..b>polyphenols, can be introduced into the sale...
  47. Marsh C, Carter H, Guelfi K, Smith K, Pike K, Naylor L, et al. Brachial and Cerebrovascular Functions Are Enhanced in Postmenopausal Women after Ingestion of Chocolate with a High Concentration of Cocoa. J Nutr. 2017;147:1686-1692 pubmed publisher
    b>Background: Cocoa contains polyphenols that are thought to be beneficial for vascular health...
  48. Davatgaran Taghipour Y, Masoomzadeh S, Farzaei M, Bahramsoltani R, Karimi Soureh Z, Rahimi R, et al. Polyphenol nanoformulations for cancer therapy: experimental evidence and clinical perspective. Int J Nanomedicine. 2017;12:2689-2702 pubmed publisher
    ..Natural polyphenols have long been used for the prevention and treatment of several disorders due to their antioxidant, anti-..
  49. Spiegler V, Liebau E, Hensel A. Medicinal plant extracts and plant-derived polyphenols with anthelmintic activity against intestinal nematodes. Nat Prod Rep. 2017;34:627-643 pubmed publisher
    ..As the development of new anthelmintic drugs against soil-transmitted helminthiases is an urgent need and polyphenols are widely used in the treatment of nematode infections in traditional medicine and modern science, we ..
  50. Schött G, Liesegang S, Gaunitz F, Gleß A, Basche S, Hannig C, et al. The chemical composition of the pharmacologically active Thymus species, its antibacterial activity against Streptococcus mutans and the antiadherent effects of T. vulgaris on the bacterial colonization of the in situ pellicle. Fitoterapia. 2017;121:118-128 pubmed publisher
    ..The composition of the essential oil and the polyphenols is important for the evaluation of the pharmacological activity...
  51. Angeloni C, Pirola L, Vauzour D, Maraldi T. Dietary polyphenols and their effects on cell biochemistry and pathophysiology. Oxid Med Cell Longev. 2012;2012:583901 pubmed publisher
  52. Tuhin R, Begum M, Rahman M, Karim R, Begum T, Ahmed S, et al. Wound healing effect of Euphorbia hirta linn. (Euphorbiaceae) in alloxan induced diabetic rats. BMC Complement Altern Med. 2017;17:423 pubmed publisher
    ..The present study demonstrates that E. hirta whole plant extract promotes healing of wounds more significantly as compared to diabetic control rats, where healing is otherwise delayed. ..
  53. Nauman M, Kale R, Singh R. Polyphenols of Salix aegyptiaca modulate the activities of drug metabolizing and antioxidant enzymes, and level of lipid peroxidation. BMC Complement Altern Med. 2018;18:81 pubmed publisher
    ..aegyptiaca, while acetylsalicylic acid provided its maximum anti-inflammatory activity. ..
  54. Carrascón V, Vallverdú Queralt A, Meudec E, Sommerer N, Fernández Zurbano P, Ferreira V. The kinetics of oxygen and SO2 consumption by red wines. What do they tell about oxidation mechanisms and about changes in wine composition?. Food Chem. 2018;241:206-214 pubmed publisher
    ..Acetaldehyde Reactive Polyphenols (ARPs) may be key elements determining OCRs...
  55. Olaokun O, McGaw L, Eloff J, Naidoo V. Evaluation of the inhibition of carbohydrate hydrolysing enzymes, antioxidant activity and polyphenolic content of extracts of ten African Ficus species (Moraceae) used traditionally to treat diabetes. BMC Complement Altern Med. 2013;13:94 pubmed publisher
    ..Research is underway to isolate the active compound(s) responsible for the antidiabetic activity and to confirm the in vitro antidiabetic activity and to investigate in vitro toxicity. ..
  56. Sukhbold E, Sekimoto S, Watanabe E, Yamazaki A, Yang L, Takasugi M, et al. Effects of oolonghomobisflavan A on oxidation of low-density lipoprotein. Biosci Biotechnol Biochem. 2017;81:1569-1575 pubmed publisher
    ..Oolong tea contains unique polyphenols including oolonghomobisflavan A (OFA)...
  57. Al Rimawi F, Abu Lafi S, Abbadi J, Alamarneh A, Sawahreh R, Odeh I. ANALYSIS OF PHENOLIC AND FLAVONOIDS OF WILD EPHEDRA ALATA PLANT EXTRACTS BY LC/PDA AND LC/MS AND THEIR ANTIOXIDANT ACTIVITY. Afr J Tradit Complement Altern Med. 2017;14:130-141 pubmed publisher
    ..On the basis of these findings, it is concluded that Ephedra alata constitutes a natural source of potent antioxidants that may prevent many diseases and could be potentially used in food, cosmetics, and pharmaceutical products. ..
  58. Kim S, Jang J, Kim J, Lee Y, Lee D, Song S, et al. Enhanced barrier functions and anti-inflammatory effect of cultured coconut extract on human skin. Food Chem Toxicol. 2017;106:367-375 pubmed publisher
    ..The promising effect of CCE may be attributed to its high levels of polyphenols and fatty acid components.
  59. Liu X, Wang Z, Wang P, Yu B, Liu Y, Xue Y. Green tea polyphenols alleviate early BBB damage during experimental focal cerebral ischemia through regulating tight junctions and PKCalpha signaling. BMC Complement Altern Med. 2013;13:187 pubmed publisher
    It has been supposed that green tea polyphenols (GTPs) have neuroprotective effects on brain damage after brain ischemia in animal experiments...
  60. Tak H, Negi S, Ganapathi T. Overexpression of MusaMYB31, a R2R3 type MYB transcription factor gene indicate its role as a negative regulator of lignin biosynthesis in banana. PLoS ONE. 2017;12:e0172695 pubmed publisher
    Lignin and polyphenols are important cellular components biosynthesized through phenylpropanoid pathway. Phenylpropanoid pathway in plants is regulated by some important transcription factors including R2R3 MYB transcription factors...
  61. Williams A, Krych L, Fauzan Ahmad H, Nejsum P, Skovgaard K, Nielsen D, et al. A polyphenol-enriched diet and Ascaris suum infection modulate mucosal immune responses and gut microbiota composition in pigs. PLoS ONE. 2017;12:e0186546 pubmed publisher
    b>Polyphenols are a class of bioactive plant secondary metabolites that are thought to have beneficial effects on gut health, such as modulation of mucosal immune and inflammatory responses and regulation of parasite burdens...
  62. Păltinean R, Mocan A, Vlase L, Gheldiu A, Crisan G, Ielciu I, et al. Evaluation of Polyphenolic Content, Antioxidant and Diuretic Activities of Six Fumaria Species. Molecules. 2017;22: pubmed publisher
    ..schleicheri increased the urinary excretion of Na⁺ and K⁺. Results from the present study offer a new perspective concerning the chemical composition and bioactivities of traditionally used fumitory species. ..
  63. Zhou Y, Zheng J, Gan R, Zhou T, Xu D, Li H. Optimization of Ultrasound-Assisted Extraction of Antioxidants from the Mung Bean Coat. Molecules. 2017;22: pubmed publisher
    ..42 ± 3.63 µmol Trolox/g DW). In addition, several antioxidant components in the extract were identified and quantified. This study is helpful for value-added utilization of the waste from germinated mung bean. ..
  64. Hinojosa Nogueira D, Muros J, Rufian Henares J, Pastoriza S. New Method To Estimate Total Polyphenol Excretion: Comparison of Fast Blue BB versus Folin-Ciocalteu Performance in Urine. J Agric Food Chem. 2017;65:4216-4222 pubmed publisher
    b>Polyphenols are bioactive substances of vegetal origin with a significant impact on human health. The assessment of polyphenol intake and excretion is therefore important...
  65. Miranda A, Albrecht C, Soria E. [Analysis of tissue bioavailability of total polyphenols by Folin Ciocalteu and Fast Blue BB techniques in organs of BALB/C/c mice]. Rev Fac Cien Med Univ Nac Cordoba. 2017;74:119-125 pubmed
    Biomedical potential of polyphenols lies in their ability to modulate redox balance and the mechanisms involved in the development of chronic noncommunicable diseases.
  66. Cheynier V, Halbwirth H. Polyphenols: Physicochemical and Biological Properties and Perspectives of Their Use in a Zero-Waste Society. J Agric Food Chem. 2017;65:6343-6345 pubmed publisher
    The 28th International Conference on Polyphenols, held in Vienna (Austria) in July 2016, offered a venue for global exchanges on the active research on polyphenols and for the presentation and discussion of the latest advances...
  67. Fukagawa S, Haramizu S, Sasaoka S, Yasuda Y, Tsujimura H, Murase T. Coffee polyphenols extracted from green coffee beans improve skin properties and microcirculatory function. Biosci Biotechnol Biochem. 2017;81:1814-1822 pubmed publisher
    Coffee polyphenols (CPPs), including chlorogenic acid, exert various physiological activities. The purpose of this study was to investigate the effects of CPPs on skin properties and microcirculatory function in humans...
  68. Wu T, Taylor C, Nebl T, Ng K, Bennett L. Effects of chemical composition and baking on in vitro digestibility of proteins in breads made from selected gluten-containing and gluten-free flours. Food Chem. 2017;233:514-524 pubmed publisher
    ..Relatively higher protein digestibility was correlated with ratio of non-fibre carbohydrate to protein and lower digestibility with increasing contents of fibre and total polyphenolics in pre-mixes. ..
  69. Furuhashi M, Hatasa Y, Kawamura S, Shibata T, Akagawa M, Uchida K. Identification of Polyphenol-Specific Innate Epitopes That Originated from a Resveratrol Analogue. Biochemistry. 2017;56:4701-4712 pubmed publisher
    b>Polyphenols have received a significant amount of attention in disease prevention because of their unique chemical and biological properties. However, the underlying molecular mechanism for their beneficial effects remains unclear...
  70. Zhang L, Wang Y, Xu M, Hu X. Galloyl moieties enhance the binding of (-)-epigallocatechin-3-gallate to ?-lactoglobulin: A spectroscopic analysis. Food Chem. 2017;237:39-45 pubmed publisher
    ..The quenching efficiency of EGCG on ?-Lg fluorescence decreased with increasing pH. Polyphenols binding results in a slight secondary structural change of ?-Lg, consistent with the fluorescence analysis...
  71. Kalmobé J, Ndjonka D, Boursou D, Vildina J, Liebau E. Phytochemical analysis and in vitro anthelmintic activity of Lophira lanceolata (Ochnaceae) on the bovine parasite Onchocerca ochengi and on drug resistant strains of the free-living nematode Caenorhabditis elegans. BMC Complement Altern Med. 2017;17:404 pubmed publisher
    ..lanceolata showed in vitro anthelmintic activity. The extracts and fractions contained polyphenols, tannins, flavonoids and saponins...
  72. Yague S, Terrón M, Gonzalez T, Zapico E, Bocchini P, Galletti G, et al. Biotreatment of tannin-rich beer-factory wastewater with white-rot basidiomycete Coriolopsis gallica monitored by pyrolysis/gas chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 2000;14:905-10 pubmed
    ..of beer-factory wastewaters represent an important environmental concern owing to their high content of polyphenols and dark-brown color...
  73. Guo J, Yuan Y, Dou P, Yue T. Multivariate statistical analysis of the polyphenolic constituents in kiwifruit juices to trace fruit varieties and geographical origins. Food Chem. 2017;232:552-559 pubmed publisher
    ..juice samples of seven kiwifruit varieties from five regions in China were analyzed to determine their polyphenols contents and to trace fruit varieties and geographical origins by multivariate statistical analysis...
  74. Alamgeer -, Uttra A, Hasan U. Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch. BMC Complement Altern Med. 2017;17:371 pubmed publisher
    ..Additionally, plant exhibited remarkable anti-oxidant activity. Moreover, phytochemical analysis revealed polyphenols and flavonoids. Taken together, these results support traditional use of B...
  75. Nguyen N, Stamper B. Polyphenols reported to shift APAP-induced changes in MAPK signaling and toxicity outcomes. Chem Biol Interact. 2017;277:129-136 pubmed publisher
    ..Overall, an emphasis should be placed on method standardization for future studies if we are to gain a more in-depth understanding of how polyphenolic moieties contribute to cytoprotection during an APAP overdose event. ..
  76. Sotelo K, Hamid N, Oey I, Pook C, Gutierrez Maddox N, Ma Q, et al. Red cherries (Prunus avium var. Stella) processed by pulsed electric field - Physical, chemical and microbiological analyses. Food Chem. 2018;240:926-934 pubmed publisher
    ..PEF) processing on cherries, in particular changes in physicochemical properties, release of anthocyanins and polyphenols, and the potential growth of lactic acid bacteria...
    ..We thereby propose, based on our findings, that the anti-free radical and anti-apoptotic inducing properties of AGTE active constituents attribute to its functional efficacy as anti-fibrotic agent. ..
  78. Nistor O, Seremet Ceclu L, Andronoiu D, Rudi L, Botez E. Influence of different drying methods on the physicochemical properties of red beetroot (Beta vulgaris L. var. Cylindra). Food Chem. 2017;236:59-67 pubmed publisher
    ..795±0.0019mg/g betaxanthin) when compared to convection at 50, 60 and 70°C. The results showed that combined drying methods led to a significant preservation of the phytochemical content as compared to the traditional methods. ..
  79. Blicharski T, Oniszczuk A, Olech M, Oniszczuk T, Wójtowicz A, Krawczyk W, et al. Puffed cereals with added chamomile - quantitative analysis of polyphenols and optimization of their extraction method. Ann Agric Environ Med. 2017;24:222-228 pubmed publisher
    ..60 °C, as well as accelerated solvent extraction (ASE) at 100 °C and 120 °C were used for the isolation of polyphenols from functional food...
  80. Li Y, Zhang X, Cui L, Chen R, Zhang Y, Zhang C, et al. Salvianolic acids enhance cerebral angiogenesis and neurological recovery by activating JAK2/STAT3 signaling pathway after ischemic stroke in mice. J Neurochem. 2017;143:87-99 pubmed publisher
    ..In summary, these data suggest that Sals administration enhances cerebral angiogenesis and promotes neurological recovery after ischemic stroke, mediated by the activation of JAK2/STAT3 signaling pathway. ..
  81. Hsu S, Wang S, Hsin I, Lee F, Huang H, Huo T, et al. Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis. Clin Sci (Lond). 2014;126:633-44 pubmed publisher
    ..GTP appears to be an appropriate agent in controlling portal hypertension-related complications via anti-angiogenesis. ..
  82. Ding S, Jiang J, Yu P, Zhang G, Zhang G, Liu X. Green tea polyphenol treatment attenuates atherosclerosis in high-fat diet-fed apolipoprotein E-knockout mice via alleviating dyslipidemia and up-regulating autophagy. PLoS ONE. 2017;12:e0181666 pubmed publisher
    ..Our findings suggest that GTP supplementation showed marked suppression of atherogenesis through improved lipid metabolism as well as through a direct impact on oxLDL and autophagy flux in the vessel wall. ..
  83. Karas D, Ulrichova J, Valentova K. Galloylation of polyphenols alters their biological activity. Food Chem Toxicol. 2017;105:223-240 pubmed publisher
    b>Polyphenols form one of the largest groups of natural compounds and possess a wide range of biological properties. These activities can be influenced by the galloyl moiety within their structures...
  84. Ganjam G, Chi T, Kietzmann T, Dimova E. Resveratrol: beneficial or not? Opposite effects of resveratrol on hypoxia-dependent PAI-1 expression in tumour and primary cells. Thromb Haemost. 2016;115:461-3 pubmed publisher
  85. Scholey A, Owen L. Effects of chocolate on cognitive function and mood: a systematic review. Nutr Rev. 2013;71:665-81 pubmed publisher
    ..Two studies have reported acute cognitive effects of supplementation with cocoa polyphenols. Further exploration of the effect of chocolate on cognitive facilitation is recommended, along with ..