luteolin

Summary

Summary: 5,7,3',4'-tetrahydroxy-flavone, one of the FLAVONES.

Top Publications

  1. Lamy S, Bédard V, Labbe D, Sartelet H, Barthomeuf C, Gingras D, et al. The dietary flavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression through inhibition of PDGFR-beta phosphorylation. Cancer Prev Res (Phila). 2008;1:452-9 pubmed publisher
    ..In this work, we show that the dietary flavones apigenin and luteolin may interfere with this event through their inhibitory effect on PDGF-dependent phosphorylation of PDGF receptor ..
  2. Shin D, Kim M, Lee S, Kim T, Kim S. Inhibitory effects of luteolin on titanium particle-induced osteolysis in a mouse model. Acta Biomater. 2012;8:3524-31 pubmed publisher
    ..In this study the ability of luteolin to inhibit both titanium (Ti) particle-induced osteoclastogenesis in vitro and osteolysis in a murine calvaria Ti ..
  3. Markaverich B, Vijjeswarapu M, Shoulars K, Rodriguez M. Luteolin and gefitinib regulation of EGF signaling pathway and cell cycle pathway genes in PC-3 human prostate cancer cells. J Steroid Biochem Mol Biol. 2010;122:219-31 pubmed publisher
    ..our lab identified five Cell Cycle Pathway (CCP) genes (CCNA2, CCNE2, CDC25A, CDKN1B, and PLK-1) as targets for luteolin in PC-3 prostate cancer cells [Shoulars et al., J. Steroid Biochem. Mol. Biol. 118 (2010) 41-50]...
  4. Sun D, Huang J, Zhang Z, Gao H, Li J, Shen M, et al. Luteolin limits infarct size and improves cardiac function after myocardium ischemia/reperfusion injury in diabetic rats. PLoS ONE. 2012;7:e33491 pubmed publisher
    The present study was to investigate the effects and mechanism of Luteolin on myocardial infarct size, cardiac function and cardiomyocyte apoptosis in diabetic rats with myocardial ischemia/reperfusion (I/R) injury...
  5. Park C, Jin K, Lee Y, Song Y. Luteolin and chicoric acid synergistically inhibited inflammatory responses via inactivation of PI3K-Akt pathway and impairment of NF-?B translocation in LPS stimulated RAW 264.7 cells. Eur J Pharmacol. 2011;660:454-9 pubmed publisher
    Synergistic anti-inflammatory effects of luteolin and chicoric acid, two abundant constituents of the common dandelion (Taraxacum officinale Weber), were investigated in lipopolysaccharide (LPS) stimulated RAW 264.7 cells...
  6. Amin A, Wang D, Zhang H, Peng S, Shin H, Brandes J, et al. Enhanced anti-tumor activity by the combination of the natural compounds (-)-epigallocatechin-3-gallate and luteolin: potential role of p53. J Biol Chem. 2010;285:34557-65 pubmed publisher
    ..In the present study, we investigated a combinatorial approach using two natural dietary polyphenols, luteolin and EGCG, and found that their combination at low doses (at which single agents induce minimal apoptosis) ..
  7. Manjolin L, dos Reis M, Maquiaveli C, Santos Filho O, da Silva E. Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection. Food Chem. 2013;141:2253-62 pubmed publisher
    Fisetin, quercetin, luteolin and 7,8-hydroxyflavone show high activity in Leishmania cultures and present low toxicity to mammalian cells...
  8. Funakoshi Tago M, Nakamura K, Tago K, Mashino T, Kasahara T. Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin. Int Immunopharmacol. 2011;11:1150-9 pubmed publisher
    ..We therefore focus on flavonoids Apigenin, Luteolin and Fisetin because of their related structure...
  9. Han D, Row K. Determination of luteolin and apigenin in celery using ultrasonic-assisted extraction based on aqueous solution of ionic liquid coupled with HPLC quantification. J Sci Food Agric. 2011;91:2888-92 pubmed publisher
    ..7% to 89.5%. Under optimal conditions, compared with conventional solvent extraction amounts of luteolin and apigenin were more than doubled.

More Information

Publications92

  1. Chen C, Peng W, Wu L, Wu C, Hsu S. Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro: implications for therapy of lung fibrosis. J Agric Food Chem. 2010;58:11653-61 pubmed publisher
    ..b>Luteolin, an active flavonoid compound isolated from Lonicera japonica, has a spectrum of biological activities, ..
  2. Cheng H, Hsieh M, Tsai F, Wu C, Chiu C, Lee M, et al. Neuroprotective effect of luteolin on amyloid beta protein (25-35)-induced toxicity in cultured rat cortical neurons. Phytother Res. 2010;24 Suppl 1:S102-8 pubmed publisher
    The present study was carried out to investigate the neuroprotective effect of luteolin on amyloid beta (Abeta) (25-35)-induced neurotoxicity using cultured rat cortical neurons...
  3. Ou Y, Li J, Kuan Y, Raung S, Wang C, Hung Y, et al. Luteolin sensitizes human 786-O renal cell carcinoma cells to TRAIL-induced apoptosis. Life Sci. 2014;100:110-7 pubmed publisher
    ..b>Luteolin, a naturally occurring flavonoid, has been identified as a potential therapeutic and preventive agent for cancer ..
  4. Asadi S, Zhang B, Weng Z, Angelidou A, Kempuraj D, Alysandratos K, et al. Luteolin and thiosalicylate inhibit HgCl(2) and thimerosal-induced VEGF release from human mast cells. Int J Immunopathol Pharmacol. 2010;23:1015-20 pubmed
    ..Pretreatment for 10 min with the flavonoid luteolin (0.1 mM) before HgCl2 or thimerosal compeletly blocked their effect...
  5. Ando C, Takahashi N, Hirai S, Nishimura K, Lin S, Uemura T, et al. Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation. FEBS Lett. 2009;583:3649-54 pubmed publisher
    ..In this study, we examined whether luteolin, food-derived flavonoid, could suppress the production of inflammatory mediators of the interaction between ..
  6. George V, Naveen Kumar D, Suresh P, Kumar S, Kumar R. Comparative studies to evaluate relative in vitro potency of luteolin in inducing cell cycle arrest and apoptosis in HaCaT and A375 cells. Asian Pac J Cancer Prev. 2013;14:631-7 pubmed
    b>Luteolin is a naturally occurring flavonoid present in many plants with diverse applications in pharmacology...
  7. Sultana S, Prasad L, Jahangir T. Luteolin ameliorates ferric nitrilotriacetic acid induced renal toxicity and tumor promotional response in rat. Indian J Exp Biol. 2009;47:355-60 pubmed
    ..However, pretreatment of animals with luteolin (10 and 20 micromol/kg body weight) for 7 consecutive days resulted in significant decrease in above parameters ..
  8. Oswald E, Sesarman A, Franzke C, Wölfle U, Bruckner Tuderman L, Jakob T, et al. The flavonoid luteolin inhibits Fc?-dependent respiratory burst in granulocytes, but not skin blistering in a new model of pemphigoid in adult mice. PLoS ONE. 2012;7:e31066 pubmed publisher
    ..We further used this new experimental model to investigate the therapeutic potential of luteolin, a plant flavonoid with potent anti-inflammatory and anti-oxidative properties and good safety profile, in ..
  9. Rezai Zadeh K, Douglas Shytle R, Bai Y, Tian J, Hou H, Mori T, et al. Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. J Cell Mol Med. 2009;13:574-88 pubmed publisher
    ..Here, we report that the citrus bioflavonoid luteolin reduces amyloid-beta (Abeta) peptide generation in both human 'Swedish' mutant APP transgene-bearing neuron-like ..
  10. Qi L, Pan H, Li D, Fang F, Chen D, Sun H. Luteolin improves contractile function and attenuates apoptosis following ischemia-reperfusion in adult rat cardiomyocytes. Eur J Pharmacol. 2011;668:201-7 pubmed publisher
    b>Luteolin occurs in a variety of plants and possesses antioxidant and anti-inflammatory properties. However, its role in protection against ischemia-reperfusion injury in Sprague-Dawley rats has not been elucidated...
  11. Yu M, Chen J, Lai C, Han C, Ko W. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. Eur J Pharmacol. 2010;627:269-75 pubmed publisher
    The aim of the present study was to investigate the mode of action of luteolin on phisphodiesterase (PDE) 1-5, and the possible adverse effects, such as nausea, vomiting, and gastric hypersecretion, determined by replacing [(3)H]-rolipram ..
  12. Xu B, Li X, He G, Hu J, Mu X, Tian S, et al. Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats. Eur J Pharmacol. 2010;627:99-105 pubmed publisher
    ..In this study, we found flavonoid luteolin could enhance basal synaptic transmission and facilitate the induction of LTP by high frequency stimulation in ..
  13. Woelfle U, Simon Haarhaus B, Merfort I, Schempp C. Reseda luteola L. extract displays antiproliferative and pro-apoptotic activities that are related to its major flavonoids. Phytother Res. 2010;24:1033-6 pubmed publisher
    Reseda luteola L. has been used as a dye due to its high luteolin content since ancient times. However, no pharmacological studies have been performed with Reseda extracts so far...
  14. Johnson J, Rupasinghe S, Stefani F, Schuler M, Gonzalez de Mejia E. Citrus flavonoids luteolin, apigenin, and quercetin inhibit glycogen synthase kinase-3? enzymatic activity by lowering the interaction energy within the binding cavity. J Med Food. 2011;14:325-33 pubmed publisher
    ..Of the 22 citrus compounds tested, the flavonoids luteolin, apigenin, and quercetin had the highest inhibitory effects on GSK-3?, with 50% inhibitory values of 1.5, 1...
  15. Liu J, Ma Y, Wang Y, Du Z, Shen J, Peng H. Reduction of lipid accumulation in HepG2 cells by luteolin is associated with activation of AMPK and mitigation of oxidative stress. Phytother Res. 2011;25:588-96 pubmed publisher
    The present study was carried out to investigate the lipid-lowering effect of luteolin by using a cell model of steatosis induced by palmitate...
  16. Tang X, Wang H, Fan L, Wu X, Xin A, Ren H, et al. Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs. Free Radic Biol Med. 2011;50:1599-609 pubmed publisher
    ..Using a cell-based ARE-reporter assay we discovered that the flavonoid luteolin is a potent Nrf2 inhibitor. Luteolin inhibited ARE-driven gene expression redox-independently...
  17. Zhu M, Chen D, Li D, Ding H, Zhang T, Xu T, et al. Luteolin inhibits angiotensin II-induced human umbilical vein endothelial cell proliferation and migration through downregulation of Src and Akt phosphorylation. Circ J. 2013;77:772-9 pubmed
    ..b>Luteolin is a type of flavonoid that has shown a positive effect on the morbidity and mortality of cardiovascular diseases...
  18. Zhou F, Chen S, Xiong J, Li Y, Qu L. Luteolin reduces zinc-induced tau phosphorylation at Ser262/356 in an ROS-dependent manner in SH-SY5Y cells. Biol Trace Elem Res. 2012;149:273-9 pubmed publisher
    ..Moreover, the current study has investigated whether luteolin (Lu), a bioflavonoid, could decrease zinc-induced tau hyperphosphorylation and its underlying mechanisms...
  19. Seelinger G, Merfort I, Wölfle U, Schempp C. Anti-carcinogenic effects of the flavonoid luteolin. Molecules. 2008;13:2628-51 pubmed
    b>Luteolin is a flavonoid which is part of our daily nutrition in relatively low amounts (less than 1 mg/day)...
  20. Song J, Liu K, Yi J, Zhu D, Liu G, Liu B. Luteolin inhibits lysophosphatidylcholine-induced apoptosis in endothelial cells by a calcium/mitocondrion/caspases-dependent pathway. Planta Med. 2010;76:433-8 pubmed publisher
    b>Luteolin, a naturally occurring polyphenol flavonoid, has demonstrated some beneficial modulation toward the endothelium...
  21. Rezai Zadeh K, Ehrhart J, Bai Y, Sanberg P, Bickford P, Tan J, et al. Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. J Neuroinflammation. 2008;5:41 pubmed publisher
    ..In particular, flavonoids, apigenin and luteolin have been found to be effective CD40 immunomodulators...
  22. Fang F, Li D, Pan H, Chen D, Qi L, Zhang R, et al. Luteolin inhibits apoptosis and improves cardiomyocyte contractile function through the PI3K/Akt pathway in simulated ischemia/reperfusion. Pharmacology. 2011;88:149-58 pubmed publisher
    b>Luteolin, a naturally occurring polyphenol flavonoid, has demonstrated to exert myocardial protection effects. However, the mechanisms have not been fully elucidated...
  23. Puhl A, Bernardes A, Silveira R, Yuan J, Campos J, Saidemberg D, et al. Mode of peroxisome proliferator-activated receptor ? activation by luteolin. Mol Pharmacol. 2012;81:788-99 pubmed publisher
    ..b>Luteolin is a flavonoid with anti-inflammatory actions that binds PPAR? but, unlike TZDs, does not promote adipocyte ..
  24. Orhan F, Gulluce M, Ozkan H, Alpsoy L. Determination of the antigenotoxic potencies of some luteolin derivatives by using a eukaryotic cell system, Saccharomyces cerevisiae. Food Chem. 2013;141:366-72 pubmed publisher
    In this study, we aimed to examine the mutagenic and antimutagenic potencies of three luteolin derivatives (luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide) by using a eukaryotic cell system, Saccharomyces ..
  25. Fang L, Zhang M, Ding Y, Fang Y, Yao C, Zhang X. [Protective effects of luteolin on neurons against oxygen-glucose deprivation/reperfusion injury via improving Na+/K+ -ATPase activity]. Zhongguo Zhong Yao Za Zhi. 2010;35:1051-4 pubmed
    b>Luteolin, a flavone, has considerable neuroprotective effects by its anti-oxidative mechanism. However, it is still unclear whether luteolin can protect neurons against oxygen-glucose deprivation/reperfusion (OGD/R) induced injury...
  26. Reipas K, Law J, Couto N, Islam S, Li Y, Li H, et al. Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1). Oncotarget. 2013;4:329-45 pubmed
    ..The lead candidate, luteolin, inhibited RSK1 and RSK2 kinase activity and suppressed growth in TNBC, including TIC-enriched populations...
  27. Wölfle U, Esser P, Simon Haarhaus B, Martin S, Lademann J, Schempp C. UVB-induced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo. Free Radic Biol Med. 2011;50:1081-93 pubmed publisher
    ..The flavonoid luteolin is one of the most potent antioxidative plant polyphenols...
  28. Pandurangan A, Dharmalingam P, Ananda Sadagopan S, Ganapasam S. Effect of luteolin on the levels of glycoproteins during azoxymethane-induced colon carcinogenesis in mice. Asian Pac J Cancer Prev. 2012;13:1569-73 pubmed
    b>Luteolin (LUT), a bioflavonoid has been used as a chemopreventive agent world-wide against chemically induced cancer...
  29. Shoulars K, Rodriguez M, Thompson T, Markaverich B. Regulation of cell cycle and RNA transcription genes identified by microarray analysis of PC-3 human prostate cancer cells treated with luteolin. J Steroid Biochem Mol Biol. 2010;118:41-50 pubmed publisher
    ..Our previous studies have shown that ligands for the nuclear type II [(3)H]estradiol binding site such as luteolin significantly inhibit prostate cancer cells in vitro and in vivo; however, the role of these ligands in cell ..
  30. Domitrovic R, Cvijanovic O, Pugel E, Zagorac G, Mahmutefendić H, Skoda M. Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney. Toxicology. 2013;310:115-23 pubmed publisher
    The aim of this study was to investigate the effects of flavone luteolin against cisplatin (CP)-induced kidney injury in mice...
  31. Sternberg Z, Chadha K, Lieberman A, Drake A, Hojnacki D, Weinstock Guttman B, et al. Immunomodulatory responses of peripheral blood mononuclear cells from multiple sclerosis patients upon in vitro incubation with the flavonoid luteolin: additive effects of IFN-beta. J Neuroinflammation. 2009;6:28 pubmed publisher
    The study is aimed to determine the role of luteolin (3',4',5,7-tetrahydroxyflavone), alone and in combination with human interferon-beta (IFN-beta), in modulating the immune response(s) of peripheral blood mononuclear cells (PBMCs) ..
  32. Sun G, Sun X, Wang M, Ye J, Si J, Xu H, et al. Oxidative stress suppression by luteolin-induced heme oxygenase-1 expression. Toxicol Appl Pharmacol. 2012;265:229-40 pubmed publisher
    b>Luteolin, a flavonoid that exhibits antioxidative properties, exerts myocardial protection effects. However, the underlying molecular mechanisms are not yet fully understood...
  33. Guo D, Li F, Yu P, Chan S. Neuroprotective effects of luteolin against apoptosis induced by 6-hydroxydopamine on rat pheochromocytoma PC12 cells. Pharm Biol. 2013;51:190-6 pubmed publisher
    ..b>Luteolin, a flavonoid, has been shown to possess various pharmacological properties including strong antioxidant capacity...
  34. Shao L, Liu K, Huang F, Guo X, Wang M, Liu B. Opposite effects of quercetin, luteolin, and epigallocatechin gallate on insulin sensitivity under normal and inflammatory conditions in mice. Inflammation. 2013;36:1-14 pubmed publisher
    Flavonoids are polyphenolic compounds ubiquitous in plants. Quercetin, luteolin, and epigallocatechin gallate (EGCG) are flavonoids with a number of biochemical and cellular actions relevant to glucose homeostasis, but their regulation of ..
  35. Qian L, Wang H, Chen Y, Chen F, Ma Y, Bruce I, et al. Luteolin reduces high glucose-mediated impairment of endothelium-dependent relaxation in rat aorta by reducing oxidative stress. Pharmacol Res. 2010;61:281-7 pubmed publisher
    While luteolin, a flavone rich in many plants, has some cardiovascular activity, it is not clear whether luteolin has beneficial effects on the vascular endothelial impairment in hyperglycemia/high glucose...
  36. Ashokkumar P, Sudhandiran G. Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis. Biomed Pharmacother. 2008;62:590-7 pubmed publisher
    The modifying effect of dietary exposure to a flavonoid, luteolin (LUT) during the azoxymethane (AOM)-induced colon carcinogenesis was investigated in this study...
  37. Ma X, Li Y, Gao Q, Ye Z, Lu X, Wang H, et al. Inhibition of superoxide anion-mediated impairment of endothelium by treatment with luteolin and apigenin in rat mesenteric artery. Life Sci. 2008;83:110-7 pubmed publisher
    ..muscle cells (SMCs) are impaired following exposure to superoxide anion, and (ii) to further investigate whether luteolin and apigenin induce vasoprotection at the vasoactive concentrations in rat mesenteric artery...
  38. Lee J, Kim S, Kim Y, Lee W, Hwang D, Lee J. Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin. Biochem Pharmacol. 2009;77:1391-400 pubmed publisher
    ..In order to evaluate the therapeutic potential of the flavonoid luteolin we examined its effect on TLR-stimulated signal transduction via the TRIF-dependent pathway...
  39. Kempuraj D, Tagen M, Iliopoulou B, Clemons A, Vasiadi M, Boucher W, et al. Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell-dependent stimulation of Jurkat T cells. Br J Pharmacol. 2008;155:1076-84 pubmed publisher
    ..following activation with myelin basic protein (MBP), as well as with or without pretreatment with the flavonoid luteolin for 15 min...
  40. Deqiu Z, Kang L, Jiali Y, Baolin L, Gaolin L. Luteolin inhibits inflammatory response and improves insulin sensitivity in the endothelium. Biochimie. 2011;93:506-12 pubmed publisher
    ..b>Luteolin, a flavonoid abundant in some medical and eatable plants, is a potent inhibitor of inflammation...
  41. Johnson J, Gonzalez de Mejia E. Interactions between dietary flavonoids apigenin or luteolin and chemotherapeutic drugs to potentiate anti-proliferative effect on human pancreatic cancer cells, in vitro. Food Chem Toxicol. 2013;60:83-91 pubmed publisher
    The objectives were to assess the potential of dietary flavonoids apigenin (Api) and luteolin (Lut) to enhance the anti-proliferative effects of chemotherapeutic drugs on BxPC-3 human pancreatic cancer cells and to investigate the ..
  42. Zhao G, Yao Yue C, Qin G, Guo L. Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons. Neurobiol Aging. 2012;33:176-86 pubmed publisher
    ..Food-derived compound luteolin possesses multitarget actions including reactive oxygen species (ROS)-scavenging activity in cultured human ..
  43. López Lázaro M. Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem. 2009;9:31-59 pubmed
    ..of this article is to summarize the distribution and biological activities of one of the most common flavonoids: luteolin. This flavonoid and its glycosides are widely distributed in the plant kingdom; they are present in many plant ..
  44. Seelinger G, Merfort I, Schempp C. Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. Planta Med. 2008;74:1667-77 pubmed publisher
    b>Luteolin is a flavone which occurs in medicinal plants as well as in some vegetables and spices...
  45. Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, et al. Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. J Neuroinflammation. 2010;7:3 pubmed publisher
    b>Luteolin, a plant derived flavonoid, exerts a variety of pharmacological activities and anti-oxidant properties associated with its capacity to scavenge oxygen and nitrogen species...
  46. Verschooten L, Barrette K, Van Kelst S, Rubio Romero N, Proby C, De Vos R, et al. Autophagy inhibitor chloroquine enhanced the cell death inducing effect of the flavonoid luteolin in metastatic squamous cell carcinoma cells. PLoS ONE. 2012;7:e48264 pubmed publisher
    ..In this study, we showed that in vitro treatment with the flavonoid Luteolin induced caspase-dependent cell death in a model of human cutaneous squamous cell carcinoma (SCC) derived cells, ..
  47. Cai X, Ye T, Liu C, Lu W, Lu M, Zhang J, et al. Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells. Toxicol In Vitro. 2011;25:1385-91 pubmed publisher
    ..investigated the underlying molecular mechanism for the potent cell cycle inhibition and pro-apoptotic effect of luteolin (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-chromenone) on human non-small-cell lung carcinoma cell line A549...
  48. Xie F, Lang Q, Zhou M, Zhang H, Zhang Z, Zhang Y, et al. The dietary flavonoid luteolin inhibits Aurora B kinase activity and blocks proliferation of cancer cells. Eur J Pharm Sci. 2012;46:388-96 pubmed publisher
    ..Here we report that the dietary flavonoid luteolin could inhibit recombinant Aurora B in radiometric activity assay (IC(50)=0...
  49. Liu A, Zhang S, Huang L, Cao Y, Yao H, Chen W, et al. Electrochemical oxidation of luteolin at a glassy carbon electrode and its application in pharmaceutical analysis. Chem Pharm Bull (Tokyo). 2008;56:745-8 pubmed
    b>Luteolin is a flavonoid reported to occur widely in many medicinal plants. The electrochemical behavior of luteolin was studied in phosphate buffer solution (PBS) of pH 4...
  50. Zhou Q, Yan B, Hu X, Li X, Zhang J, Fang J. Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin. Mol Cancer Ther. 2009;8:1684-91 pubmed publisher
    b>Luteolin, a common dietary flavonoid, has been found to have antitumor properties and therefore poses special interest for the development of preventive and/or therapeutic agent for cancers...
  51. Pandurangan A, Dharmalingam P, Sadagopan S, Ramar M, Munusamy A, Ganapasam S. Luteolin induces growth arrest in colon cancer cells through involvement of Wnt/?-catenin/GSK-3? signaling. J Environ Pathol Toxicol Oncol. 2013;32:131-9 pubmed
    ..b>Luteolin, a bioflavonoid, possesses antioxidant, anti-inflammatory, and antiproliferative effects...
  52. Chen X, Liu L, Sun Z, Liu Y, Xu J, Liu S, et al. Pharmacokinetics of luteolin and tetra-acetyl-luteolin assayed by HPLC in rats after oral administration. Biomed Chromatogr. 2010;24:826-32 pubmed publisher
    Accurate and reproducible HPLC methods were developed and validated for the determination of concentrations of luteolin (LT) and tetra-acetyl-luteolin (TALT) in rat plasma...
  53. Choi B, Lim D, Lee J, Gao S, Kwon D, Kim B. Luteolin suppresses cisplatin-induced apoptosis in auditory cells: possible mediation through induction of heme oxygenase-1 expression. J Med Food. 2008;11:230-6 pubmed publisher
    b>Luteolin has been shown to possess antitumorigenic, antioxidant, and anti-inflammatory properties...
  54. Xu K, Liu B, Ma Y, Du J, Li G, Gao H, et al. Physicochemical properties and antioxidant activities of luteolin-phospholipid complex. Molecules. 2009;14:3486-93 pubmed publisher
    A luteolin and phospholipid complex was prepared to improve the lipophilic properties of luteolin...
  55. Choi E, Lee Y. Luteolin suppresses IL-1beta-induced cytokines and MMPs production via p38 MAPK, JNK, NF-kappaB and AP-1 activation in human synovial sarcoma cell line, SW982. Food Chem Toxicol. 2010;48:2607-11 pubmed publisher
    ..This study was conducted to evaluate the efficacy of luteolin in regulating interleukin-1beta (IL-1beta)-induced production of MMPs (MMP-1 and -3) and cytokines (tumor ..
  56. Ramos A, Pereira Wilson C, Collins A. Protective effects of ursolic acid and luteolin against oxidative DNA damage include enhancement of DNA repair in Caco-2 cells. Mutat Res. 2010;692:6-11 pubmed publisher
    ..we evaluated the effects of two compounds present in fruits and vegetables, ursolic acid, a triterpenoid, and luteolin, a flavonoid, on DNA protection and DNA repair in Caco-2 cells using the comet assay...
  57. Liao P, Hung L, Chen Y, Kuan Y, Zhang F, Lin R, et al. Cardioprotective effects of luteolin during ischemia-reperfusion injury in rats. Circ J. 2011;75:443-50 pubmed
    Antioxidants effectively reduce ischemia-reperfusion (IR) injury. The cardioprotective effects of luteolin, a flavonoid that exhibits antioxidant properties and is widely available in many fruits and vegetables, were examined in rats ..
  58. He D, Ma X, Chen Y, Cai Y, Ru X, Bruce I, et al. Luteolin inhibits pyrogallol-induced apoptosis through the extracellular signal-regulated kinase signaling pathway. FEBS J. 2012;279:1834-43 pubmed publisher
    b>Luteolin is an antioxidative, antitumor and anti-inflammatory flavone. It has been shown to reduce endothelial dysfunction, but the mechanism is not clear...
  59. Lee J, Li Y, Chen H, Lin R, Huang S, Chen H, et al. Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils. Acta Pharmacol Sin. 2010;31:831-8 pubmed publisher
    To investigate whether luteolin, the major polyphenolic components of Lonicera japonica, has beneficial effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) and to determine whether the protective mechanism involves ..
  60. Park H, Kim S, Kim Y, Ryu S, Hwang J, Yang H, et al. Luteolin inhibits adipogenic differentiation by regulating PPARgamma activation. Biofactors. 2009;35:373-9 pubmed publisher
    b>Luteolin (3',4',5,7-tetrahydroxyflavone), a flavonoid, has been known to possess antimutagenic, antitumorigenic, antioxidant, and anti-inflammatory properties...
  61. Zhang Y, Gan F, Shelar S, Ng K, Chew E. Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury. Food Chem Toxicol. 2013;59:272-80 pubmed publisher
    ..Among the five isolated flavonoids, luteolin was evaluated to possess direct and indirect antioxidant activities by scavenging free radicals and inducing the ..
  62. Leemans J, Cambier C, Chandler T, Billen F, Clercx C, Kirschvink N, et al. Prophylactic effects of omega-3 polyunsaturated fatty acids and luteolin on airway hyperresponsiveness and inflammation in cats with experimentally-induced asthma. Vet J. 2010;184:111-4 pubmed publisher
    ..The aim of this study was to assess the preventive effects of omega-3 polyunsaturated fatty acids (omega3 PUFA) and luteolin supplementation on allergen-induced inflammation in eight Ascaris suum (AS)-sensitised cats...
  63. Tsai F, Cheng H, Hsieh M, Wu C, Lin Y, Peng W. The ameliorating effects of luteolin on beta-amyloid-induced impairment of water maze performance and passive avoidance in rats. Am J Chin Med. 2010;38:279-91 pubmed
    The present study investigated the effects of luteolin on Abeta (1-40)-induced impairment of Morris water maze (MWM) spatial performance, reference memory, and passive avoidance (PA) behavior in rats...
  64. Qiao H, Zhang X, Zhu C, Dong L, Wang L, Zhang X, et al. Luteolin downregulates TLR4, TLR5, NF-?B and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia. Brain Res. 2012;1448:71-81 pubmed publisher
    Inflammatory damage is known to be involved in ischemic stroke. Luteolin has been proved to elicit a series of biologic effects through its anti-inflammatory property in multiple sclerosis and rheumatoid arthritis...
  65. Wall C, Lim R, Poljak M, Lappas M. Dietary flavonoids as therapeutics for preterm birth: luteolin and kaempferol suppress inflammation in human gestational tissues in vitro. Oxid Med Cell Longev. 2013;2013:485201 pubmed publisher
    ..In nongestational tissues, dietary flavonoids such as luteolin and kaempferol inhibit NF-?B, AP-1, and their downstream targets...
  66. Cai X, Lu W, Ye T, Lu M, Wang J, Huo J, et al. The molecular mechanism of luteolin-induced apoptosis is potentially related to inhibition of angiogenesis in human pancreatic carcinoma cells. Oncol Rep. 2012;28:1353-61 pubmed publisher
    b>Luteolin has been shown to have a strong anticancer effect on various cancer models via programmed cell death (apoptosis). However, the fundamental mechanisms of these effects are still unclear...
  67. Shen H, Guo Q, Fang H, Wang Y, Jin M. [Determination of quercetin, luteolin, apigenin and acacetin in Flos Chrysanthemi Indici by RP-HPLC]. Zhongguo Zhong Yao Za Zhi. 2010;35:191-3 pubmed
    To develop a RP-HPLC method for the determination of quercetin, luteolin, apigenin and acacetin in Flos Chrysanthemi indici. An Eclipse XDB-C18 column (4...
  68. Lee H, Yang W, Bao B, Lo P. Proteomic analysis reveals ATP-dependent steps and chaperones involvement in luteolin-induced lung cancer CH27 cell apoptosis. Eur J Pharmacol. 2010;642:19-27 pubmed publisher
    The present study applied 2D electrophoresis to analyze the proteins involved in luteolin (50 microM)-induced CH27 cell apoptosis. We found 7 proteins to be markedly changed...
  69. Ong C, Zhou J, Ong C, Shen H. Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt-GSK-3?-Cyclin D1 pathway. Cancer Lett. 2010;298:167-75 pubmed publisher
    b>Luteolin, a plant flavonoid is known to possess multiple biological activities such as anti-inflammation, anti-allergy, anti-oxidant as well as anti-cancer...
  70. Kim T, Jung J, Ha B, Hong J, Park E, Kim H, et al. The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss. J Nutr Biochem. 2011;22:8-15 pubmed publisher
    ..b>Luteolin, a plant flavonoid, has potent anti-inflammatory properties both in vivo and vitro...
  71. An S, Kim H, Kim J, Boo Y. Flavonoids, taxifolin and luteolin attenuate cellular melanogenesis despite increasing tyrosinase protein levels. Phytother Res. 2008;22:1200-7 pubmed publisher
    ..in murine melanoma B16F10 cells activated by alpha-melanocyte stimulating hormone (alpha-MSH), taxifolin and luteolin inhibited the cellular melanogenesis as effectively as arbutin, one of the most widely used hypopigmenting agents ..
  72. Androutsopoulos V, Spandidos D. The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation. J Nutr Biochem. 2013;24:496-504 pubmed publisher
    ..Diosmetin was converted to luteolin in HepG2 cells after 12 and 30 h of incubation...
  73. Wang G, Li W, Lu X, Bao P, Zhao X. Luteolin ameliorates cardiac failure in type I diabetic cardiomyopathy. J Diabetes Complications. 2012;26:259-65 pubmed publisher
    The study aimed to determine whether luteolin can confer cardioprotective effects against diabetic cardiomyopathy in relation to specific and quantitative markers of oxidative stress...
  74. Li L, Wu X, Chen Z, Sun S, Ye J, Zeng S, et al. Interspecies difference of luteolin and apigenin after oral administration of Chrysanthemum morifolium extract and prediction of human pharmacokinetics. Pharmazie. 2013;68:195-200 pubmed
    The aims of the present study were to study the interspecies difference in the pharmacokinetics of luteolin and apigenin occurring in Chrysanthemum morifolium extract (CME) among rats, beagle dogs, mini-pigs, and humans, and compared the ..
  75. Wu Y, Fang X. Apigenin, chrysin, and luteolin selectively inhibit chymotrypsin-like and trypsin-like proteasome catalytic activities in tumor cells. Planta Med. 2010;76:128-32 pubmed publisher
    ..mechanism of flavonoids, we examined the effects of the plant flavonoids apigenin, chrysin, and luteolin on the three individual catalytic activities in various cancer cell lines...
  76. Choi A, Choi J, Yoon H, Hwang K, Noh M, Choe W, et al. Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells. Eur J Pharmacol. 2011;668:115-26 pubmed publisher
    b>Luteolin, a dietary flavonoid, induces apoptosis in various types of cancer cells. However, its role in neuroblastoma and the underlying mechanisms remain to be elucidated...
  77. Xavier C, Lima C, Preto A, Seruca R, Fernandes Ferreira M, Pereira Wilson C. Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. Cancer Lett. 2009;281:162-70 pubmed publisher
    ..of CRC incidence and progression, we studied the effects of the dietary phytochemicals quercetin (Q), luteolin (L) and ursolic acid (UA) on cell proliferation and apoptosis in two human CRC derived cell lines, HCT15 and ..
  78. Huang C, Lii C, Lin A, Yeh Y, Yao H, Li C, et al. Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes. Arch Toxicol. 2013;87:167-78 pubmed publisher
    Chrysin, apigenin, and luteolin are flavones that differ in their number of hydroxyl groups in the B ring...
  79. Wang Q, Xie M. [Antibacterial activity and mechanism of luteolin on Staphylococcus aureus]. Wei Sheng Wu Xue Bao. 2010;50:1180-4 pubmed
    To investigate the antibacterial activity and mechanism of luteolin on Staphylococcus aureus...
  80. Kao T, Ou Y, Lin S, Pan H, Song P, Raung S, et al. Luteolin inhibits cytokine expression in endotoxin/cytokine-stimulated microglia. J Nutr Biochem. 2011;22:612-24 pubmed publisher
    ..b>Luteolin, a naturally occurring polyphenolic flavonoid antioxidant, has potent anti-inflammatory and neuroprotective ..
  81. Kang O, Choi J, Lee J, Kwon D. Luteolin isolated from the flowers of Lonicera japonica suppresses inflammatory mediator release by blocking NF-kappaB and MAPKs activation pathways in HMC-1 cells. Molecules. 2010;15:385-98 pubmed publisher
    b>Luteolin (3',4',5,7-tetrahydroxylflavone) is a plant flavonoid and pharmacologically active agent that has been isolated from several plant species...
  82. Ashokkumar P, Sudhandiran G. Luteolin inhibits cell proliferation during Azoxymethane-induced experimental colon carcinogenesis via Wnt/ ?-catenin pathway. Invest New Drugs. 2011;29:273-84 pubmed publisher
    The protective role of Luteolin (LUT) against Azoxymethane (AOM)-induced mouse colon carcinogenesis has been documented earlier...
  83. Pratheeshkumar P, Son Y, Budhraja A, Wang X, Ding S, Wang L, et al. Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. PLoS ONE. 2012;7:e52279 pubmed publisher
    ..b>Luteolin is a common dietary flavonoid found in fruits and vegetables...