apigenin

Summary

Summary: 5,7,4'-trihydroxy-flavone, one of the FLAVONES.

Top Publications

  1. Kang O, Lee J, Kwon D. Apigenin inhibits release of inflammatory mediators by blocking the NF-?B activation pathways in the HMC-1 cells. Immunopharmacol Immunotoxicol. 2011;33:473-9 pubmed publisher
    b>Apigenin is a plant flavonoid and a pharmacologically active agent that has been isolated from several plant species. However, the molecular mechanism of apigenin-mediated immune modulation has not been fully understood...
  2. Al Shaal L, Shegokar R, Muller R. Production and characterization of antioxidant apigenin nanocrystals as a novel UV skin protective formulation. Int J Pharm. 2011;420:133-40 pubmed publisher
    ..To overcome the poor solubility, apigenin nanosuspensions were prepared using the combination technology (CT), i.e...
  3. Yi Lau G, Leung L. The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines. Food Chem Toxicol. 2010;48:3022-7 pubmed publisher
    ..Its expression has been linked to the process of carcinogenesis, including tumorigenesis of the breast. Apigenin (APG) is a flavone commonly found in fruit and vegetables, and is shown to be a potential modulator in ..
  4. Arango D, Parihar A, Villamena F, Wang L, Freitas M, Grotewold E, et al. Apigenin induces DNA damage through the PKC?-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair. Biochem Pharmacol. 2012;84:1571-80 pubmed publisher
    b>Apigenin, an abundant plant flavonoid, exhibits anti-proliferative and anti-carcinogenic activities through mechanisms yet not fully defined...
  5. Yamagata K, Miyashita A, Chino M, Matsufuji H. Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells. Microvasc Res. 2011;81:60-7 pubmed publisher
    ..HG plus TNF? strongly induced LOX-1 and AT1R expression in the EC. Furthermore, apigenin, kaempferol, chrysin, and flavone significantly inhibited HG plus TNF?-induced LOX-1 expression...
  6. Maggioni D, Garavello W, Rigolio R, Pignataro L, Gaini R, Nicolini G. Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis. Int J Oncol. 2013;43:1675-82 pubmed publisher
    In the present study, we investigated the effect of apigenin, a flavonoid widely present in fruits and vegetables, on a tongue oral cancer-derived cell line (SCC-25) and on a keratinocyte cell line (HaCaT), with the aim of unveiling its ..
  7. Johnson J, Gonzalez de Mejia E. Interactions between dietary flavonoids apigenin or luteolin and chemotherapeutic drugs to potentiate anti-proliferative effect on human pancreatic cancer cells, in vitro. Food Chem Toxicol. 2013;60:83-91 pubmed publisher
    The objectives were to assess the potential of dietary flavonoids apigenin (Api) and luteolin (Lut) to enhance the anti-proliferative effects of chemotherapeutic drugs on BxPC-3 human pancreatic cancer cells and to investigate the ..
  8. Oishi M, Iizumi Y, Taniguchi T, Goi W, Miki T, Sakai T. Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2. PLoS ONE. 2013;8:e55922 pubmed publisher
    ..Here we show that the dietary flavonoid apigenin binds and inhibits adenine nucleotide translocase-2 (ANT2), resulting in enhancement of Apo2L/TRAIL-induced ..
  9. Dai H, Gu J, Li L, Yang L, Liu H, Li J. Scutellarin benzyl ester partially secured the ischemic injury by its anti-apoptosis mechanism in cardiomyocytes of neonatal rats. Zhong Xi Yi Jie He Xue Bao. 2011;9:1014-21 pubmed
    ..01). Scutellarin benzyl ester has a remarkable protective effect against myocardial ischemic injury and the protective mechanism may associate with its anti-apoptosis effect by inhibiting cytochrome c release and caspase-3 activation. ..

More Information

Publications84

  1. Arsić I, Tadić V, Vlaović D, Homsek I, Vesic S, Isailović G, et al. Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy. Phytother Res. 2011;25:228-33 pubmed publisher
    Two oil-in-water formulations, containing equal amounts of apigenin-enriched chamomile flower extracts, for potential use as topical antiinflammatory agents, were prepared and their physicochemical properties evaluated...
  2. Chan L, Chou T, Ding H, Chen P, Chiang F, Kuo P, et al. Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin. Biochim Biophys Acta. 2012;1820:1081-91 pubmed publisher
    b>Apigenin, a natural plant flavone, may have chemopreventive and therapeutic potentials for anti-inflammatory, antioxidant, and anti-cancer...
  3. Lu X, Sun D, Chen Z, Chen T, Li L, Xu Z, et al. Relative contribution of small and large intestine to deglycosylation and absorption of flavonoids from Chrysanthemun morifolium extract. J Agric Food Chem. 2010;58:10661-7 pubmed publisher
    ..Luteolin and apigenin flavonoids are the effective components of the CM extract (CME); however, they exist in the orally consumed CME ..
  4. Nakazaki E, Tsolmon S, Han J, Isoda H. Proteomic study of granulocytic differentiation induced by apigenin 7-glucoside in human promyelocytic leukemia HL-60 cells. Eur J Nutr. 2013;52:25-35 pubmed publisher
    ..another approach of cancer prevention through cancer cell differentiation, using a common non-mutagenic flavonoid apigenin 7-glucoside. HL-60 cells were treated with or without apigenin 7-glucoside...
  5. Das S, Das J, Samadder A, Paul A, Khuda Bukhsh A. Efficacy of PLGA-loaded apigenin nanoparticles in Benzo[a]pyrene and ultraviolet-B induced skin cancer of mice: mitochondria mediated apoptotic signalling cascades. Food Chem Toxicol. 2013;62:670-80 pubmed publisher
    ..We loaded apigenin (Ap), a dietary flavonoid having anti-cancer property, with poly (lactic-co-glycolide) (PLGA) nanoparticles (NAp) ..
  6. Wang Y, Huang K. In vitro anti-inflammatory effect of apigenin in the Helicobacter pylori-infected gastric adenocarcinoma cells. Food Chem Toxicol. 2013;53:376-83 pubmed publisher
    ..b>Apigenin (4',5,7-trihydroxyflavone) is widely distributed in fruits and vegetables, and is a well-known antiinflammatory ..
  7. Singh P, Mishra S, Noel S, Sharma S, Rath S. Acute exposure of apigenin induces hepatotoxicity in Swiss mice. PLoS ONE. 2012;7:e31964 pubmed publisher
    b>Apigenin, a dietary flavonoid, is reported to have several therapeutic effects in different diseases including cancer. Toxicity of Apigenin is however, least explored, and reports are scanty in literature...
  8. Li L, Wu X, Chen Z, Sun S, Ye J, Zeng S, et al. Interspecies difference of luteolin and apigenin after oral administration of Chrysanthemum morifolium extract and prediction of human pharmacokinetics. Pharmazie. 2013;68:195-200 pubmed
    The aims of the present study were to study the interspecies difference in the pharmacokinetics of luteolin and apigenin occurring in Chrysanthemum morifolium extract (CME) among rats, beagle dogs, mini-pigs, and humans, and compared the ..
  9. Mandery K, Bujok K, Schmidt I, Keiser M, Siegmund W, Balk B, et al. Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochem Pharmacol. 2010;80:1746-53 pubmed publisher
    ..cell lines stably expressing OATP1A2 and OATP2B1 were used to investigate the influence of the Ginkgo flavonoids apigenin, kaempferol, and quercetin on the transport activity of OATP1A2 and OATP2B1...
  10. Arango D, Morohashi K, Yilmaz A, Kuramochi K, Parihar A, Brahimaj B, et al. Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets. Proc Natl Acad Sci U S A. 2013;110:E2153-62 pubmed publisher
    ..Here, we describe the identification of human cellular targets of apigenin, a flavonoid abundantly present in fruits and vegetables, using an innovative high-throughput approach that ..
  11. Silvan S, Manoharan S, Baskaran N, Anusuya C, Karthikeyan S, Prabhakar M. Chemopreventive potential of apigenin in 7,12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis. Eur J Pharmacol. 2011;670:571-7 pubmed publisher
    Aim was to investigate the chemopreventive potential of apigenin by analyzing the tumor incidence as well as monitoring lipid peroxidation, antioxidants and phase I and phase II detoxification as biomarkers during DMBA induced hamster ..
  12. Chen C, Ke W, Ceng L, Hsieh C, Wung B. Calcium- and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin. Life Sci. 2010;87:743-9 pubmed publisher
    ..The objective of our present study was to investigate the effects of the flavone compound, apigenin, on eNOS activity and elucidate the molecular mechanisms underlying these effects in endothelial cells (ECs)...
  13. Pan Z, Zhao W, Zhang X, Wang B, Wang J, Sun X, et al. Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGF?1 expression and activation of p38-MAPK and ERK1/2. Br J Pharmacol. 2011;162:688-700 pubmed publisher
  14. Chen Y, Jia X, Chen J, Wang J, Hu M. The pharmacokinetics of raloxifene and its interaction with apigenin in rat. Molecules. 2010;15:8478-87 pubmed publisher
    ..raloxifene in vitro, we evaluated the in vivo pharmacokinetics of raloxifene in rats when co-administered with apigenin. The pharmacokinetics of raloxifene in the absence or presence of apigenin was investigated in rats after ..
  15. Zhao L, Wang J, Wang Y, Fa X. Apigenin attenuates copper-mediated ?-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model. Brain Res. 2013;1492:33-45 pubmed publisher
    b>Apigenin, belonging to a less toxic and non-mutagenic flavone subclass of flavonoids, has been reported to possess numerous biological activities beneficial to health...
  16. Gonzalez Mejia M, Voss O, Murnan E, Doseff A. Apigenin-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein-27. Cell Death Dis. 2010;1:e64 pubmed publisher
    b>Apigenin, a natural plant flavonoid with antiproliferative activity, is emerging as a promising compound for cancer prevention and therapy, but its mechanism of action remains unclear...
  17. Zhong Y, Krisanapun C, Lee S, Nualsanit T, Sams C, Peungvicha P, et al. Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53. Eur J Cancer. 2010;46:3365-74 pubmed publisher
    ..We sought to develop the best flavonoids for the inhibition of cell growth, and apigenin (flavone) proved to be the most promising compound in colorectal cancer cell growth arrest...
  18. Zhao M, Ma J, Zhu H, Zhang X, Du Z, Xu Y, et al. Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90. Mol Cancer. 2011;10:104 pubmed publisher
    ..b>Apigenin, a common flavonoid, has been reported to suppress proliferation in a wide variety of solid tumors and ..
  19. Mafuvadze B, Benakanakere I, Hyder S. Apigenin blocks induction of vascular endothelial growth factor mRNA and protein in progestin-treated human breast cancer cells. Menopause. 2010;17:1055-63 pubmed publisher
    ..The objective of this study was to examine whether apigenin, a natural flavone, inhibits the progestin-dependent induction of VEGF in human breast cancer cells...
  20. Ding J, Polier G, Kohler R, Giaisi M, Krammer P, Li Weber M. Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. J Biol Chem. 2012;287:641-9 pubmed publisher
    ..Here, we show that wogonin and the structurally related natural flavones apigenin and chrysin break TRAIL resistance in HTLV-1-associated ATL by transcriptional down-regulation of c-FLIP, a key ..
  21. Munyendo W, Zhang Z, Abbad S, Waddad A, Lv H, Baraza L, et al. Micelles of TPGS modified apigenin phospholipid complex for oral administration: preparation, in vitro and in vivo evaluation. J Biomed Nanotechnol. 2013;9:2034-47 pubmed
    Mixed micelles were designed to increase oral bioavailability of Apigenin (Ap). The phospholipid (Ph) complex technology was exploited alongside TPGS' stabilizing effect by PEG chain sterical hindrance of the phase II enzymes...
  22. Mohan N, Banik N, Ray S. Combination of N-(4-hydroxyphenyl) retinamide and apigenin suppressed starvation-induced autophagy and promoted apoptosis in malignant neuroblastoma cells. Neurosci Lett. 2011;502:24-9 pubmed publisher
    ..We explored efficacy of the synthetic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR) and the isoflavonoid apigenin (APG) in the serum-starved human malignant neuroblastoma cells. Combination of 0...
  23. Begum N, Prasad N, Kanimozhi G, Hasan A. Apigenin ameliorates gamma radiation-induced cytogenetic alterations in cultured human blood lymphocytes. Mutat Res. 2012;747:71-6 pubmed publisher
    The aim of the present study was to assess the protective effect of apigenin, a dietary flavone, against cytogenetic alterations in human peripheral blood lymphocytes (HPBL) induced by Cobalt-60 radiation (3Gy)...
  24. Masuelli L, Marzocchella L, Quaranta A, Palumbo C, Pompa G, Izzi V, et al. Apigenin induces apoptosis and impairs head and neck carcinomas EGFR/ErbB2 signaling. Front Biosci (Landmark Ed). 2011;16:1060-8 pubmed
    ..The aim of this study was to investigate the effect of apigenin, a low molecular weight flavonoid contained in fruits and vegetables, on growth and survival and on EGFR/ErbB2 ..
  25. Kim E, Yu J, Yang M, Kim A. Sub-toxic dose of apigenin sensitizes HepG2 cells to TRAIL through ERK-dependent up-regulation of TRAIL receptor DR5. Mol Cells. 2013;35:32-40 pubmed publisher
    ..In this study, we investigated the underlying mechanism of apigenin-induced sensitization of HepG2 cells to TRAIL-induced cell death...
  26. Gao A, Ke Z, Wang J, Yang J, Chen S, Chen H. Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway. Carcinogenesis. 2013;34:1806-14 pubmed publisher
    ..In the present study, we found that non-toxic dose of apigenin (APG) significantly sensitizes doxorubicin-resistant BEL-7402 (BEL-7402/ADM) cells to doxorubicin (ADM) and ..
  27. Vitcheva V, Simeonova R, Krasteva I, Yotova M, Nikolov S, Mitcheva M. Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. Redox Rep. 2011;16:56-61 pubmed publisher
    ..The results of this study proved the antioxidant activity of saponarin and its protective effect against cocaine-induced oxidative stress and hepatotoxicity. ..
  28. Chakrabarti M, Banik N, Ray S. miR-138 overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo. Exp Cell Res. 2013;319:1575-85 pubmed publisher
    ..Transfection with hTERT shRNA plasmid followed by treatment with the flavonoid apigenin (APG) further increased expression of miR-138...
  29. Lampropoulos P, Lambropoulou M, Papalois A, Basios N, Manousi M, Simopoulos C, et al. The role of apigenin in an experimental model of acute pancreatitis. J Surg Res. 2013;183:129-37 pubmed publisher
    ..An effort was made to clarify the role of apigenin, a substance that is well-known for its antioxidant and anti-inflammatory role and its likely beneficial activity ..
  30. Li H, Huang D, Gao Z, Lv Y, Zhang L, Cui H, et al. Scutellarin inhibits cell migration by regulating production of ?v?6 integrin and E-cadherin in human tongue cancer cells. Oncol Rep. 2010;24:1153-60 pubmed
    ..This study shows that scutellarin inhibits tumor cell proliferation and migration and regulates cell adhesion in OSCC cells; this may be closely related to up-regulation of E-cadherin and down-regulation of ?v?6 integrin...
  31. Rithidech K, Tungjai M, Reungpatthanaphong P, Honikel L, Simon S. Attenuation of oxidative damage and inflammatory responses by apigenin given to mice after irradiation. Mutat Res. 2012;749:29-38 pubmed publisher
    We determined the in vivo efficacy of apigenin, as an anti-oxidant and anti-inflammatory agent, given to mice after irradiation...
  32. Melstrom L, Salabat M, Ding X, Strouch M, Grippo P, Mirzoeva S, et al. Apigenin down-regulates the hypoxia response genes: HIF-1?, GLUT-1, and VEGF in human pancreatic cancer cells. J Surg Res. 2011;167:173-81 pubmed publisher
    The flavonoid apigenin exhibits anti-proliferative and anti-angiogenic activities. Our objective was to evaluate the effect of apigenin on hypoxia responsive genes important in pancreatic cancer cell proliferation...
  33. Wójcik K, Skoda M, Koczurkiewicz P, Sanak M, Czyz J, Michalik M. Apigenin inhibits TGF-?1 induced fibroblast-to-myofibroblast transition in human lung fibroblast populations. Pharmacol Rep. 2013;65:164-72 pubmed
    ..Due to anti-allergic and anti-inflammatory activities, apigenin (4',5,7,-trihydroxyflavone) is thought to interfere with crucial events in the pathomechanism of asthma...
  34. Kim S, Kang J, Kim C, Ihm S, Choi M, Yoo H, et al. Apigenin induces c-Myc-mediated apoptosis in FRO anaplastic thyroid carcinoma cells. Mol Cell Endocrinol. 2013;369:130-9 pubmed publisher
    b>Apigenin promotes apoptosis in cancer cells. We studied the effect of apigenin on cell survival and c-Myc expression in FRO anaplastic thyroid carcinoma (ATC) cells...
  35. Anter J, Romero Jiménez M, Fernández Bedmar Z, Villatoro Pulido M, Analla M, Alonso Moraga A, et al. Antigenotoxicity, cytotoxicity, and apoptosis induction by apigenin, bisabolol, and protocatechuic acid. J Med Food. 2011;14:276-83 pubmed publisher
    ..this work was to evaluate the genotoxic, antigenotoxic, tumoricidal, and apoptotic effect of some major phenols (apigenin, bisabolol, and protocatechuic acid) from two medicinal plants, Matricaria chamomilla and Uncaria tomentosa...
  36. Byun S, Park J, Lee E, Lim S, Yu J, Lee S, et al. Src kinase is a direct target of apigenin against UVB-induced skin inflammation. Carcinogenesis. 2013;34:397-405 pubmed publisher
    b>Apigenin, a flavonoid abundant in various vegetables and fruits, including parsley and onions, has been reported to possess anticarcinogenic effects...
  37. Han J, Ahn S, Kim C, Yoo S, Kim S, Kim H, et al. Protection of apigenin against kainate-induced excitotoxicity by anti-oxidative effects. Biol Pharm Bull. 2012;35:1440-6 pubmed
    b>Apigenin (5,7,4'-trihydroxyflavone) is a principal ingredient of Cirsium japonicum...
  38. Pawlikowska Pawlega B, Misiak L, Zarzyka B, Paduch R, Gawron A, Gruszecki W. FTIR, (1)H NMR and EPR spectroscopy studies on the interaction of flavone apigenin with dipalmitoylphosphatidylcholine liposomes. Biochim Biophys Acta. 2013;1828:518-27 pubmed publisher
    b>Apigenin (5,7,4'-trihydroxyflavone) is a cancer chemopreventive agent and a member of the family of plant flavonoids...
  39. Johnson J, Rupasinghe S, Stefani F, Schuler M, Gonzalez de Mejia E. Citrus flavonoids luteolin, apigenin, and quercetin inhibit glycogen synthase kinase-3? enzymatic activity by lowering the interaction energy within the binding cavity. J Med Food. 2011;14:325-33 pubmed publisher
    ..Of the 22 citrus compounds tested, the flavonoids luteolin, apigenin, and quercetin had the highest inhibitory effects on GSK-3?, with 50% inhibitory values of 1.5, 1.9, and 2...
  40. Ono M, Fujimori K. Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells. J Agric Food Chem. 2011;59:13346-52 pubmed publisher
    ..Here we investigated the effects of dietary apigenin, a plant flavonoid, on adipogenesis...
  41. Li W, Pandey A, Yin X, Chen J, Stocco D, Grammas P, et al. Effects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse Leydig cells. J Nutr Biochem. 2011;22:212-8 pubmed publisher
    ..of delaying this decline using a dietary approach, we have examined the effect of a natural flavonoid, apigenin, on StAR gene expression in mouse Leydig cells...
  42. Wu D, Yu P, Li J, Jiang P, Sun J, Wang H, et al. Apigenin potentiates the growth inhibitory effects by IKK-?-mediated NF-?B activation in pancreatic cancer cells. Toxicol Lett. 2014;224:157-64 pubmed publisher
    b>Apigenin is a potential chemopreventive agent for cancer prevention...
  43. Chen W, Hsieh Y, Tsai C, Kang Y, Chang F, Wu Y, et al. Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferase ?. Invest New Drugs. 2011;29:1347-59 pubmed publisher
    Protoapigenone, a natural derivative of the flavonoid apigenin, has been shown to exhibit potent antitumor activity in vitro and in vivo; the precise mechanism of action, however, is not fully elucidated...
  44. Duarte S, Arango D, Parihar A, Hamel P, Yasmeen R, Doseff A. Apigenin protects endothelial cells from lipopolysaccharide (LPS)-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function. Int J Mol Sci. 2013;14:17664-79 pubmed publisher
    ..In the present study, we evaluated the effects of apigenin, an anti-inflammatory flavonoid abundantly found in our diet, in endothelial cells during inflammation...
  45. Chunhua L, Donglan L, Xiuqiong F, Lihua Z, Qin F, Yawei L, et al. Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT. J Nutr Biochem. 2013;24:1766-75 pubmed publisher
    Colorectal cancer (CRC) is a major cause of morbidity and mortality throughout the world. Apigenin is a flavonoid that possesses various clinically relevant properties such as anti-tumour, anti-platelet and anti-inflammatory activities...
  46. Mohan N, Ai W, Chakrabarti M, Banik N, Ray S. KLF4 overexpression and apigenin treatment down regulated anti-apoptotic Bcl-2 proteins and matrix metalloproteinases to control growth of human malignant neuroblastoma SK-N-DZ and IMR-32 cells. Mol Oncol. 2013;7:464-74 pubmed publisher
    ..We examined the effects of KLF4 overexpression and apigenin (APG) treatment in human malignant neuroblastoma SK-N-DZ and IMR-32 cell lines...
  47. Zhang J, Huang Y, Liu D, Gao Y, Qian S. Preparation of apigenin nanocrystals using supercritical antisolvent process for dissolution and bioavailability enhancement. Eur J Pharm Sci. 2013;48:740-7 pubmed publisher
    The aim of the study was to investigate the potential of nanocrystals to enhance the oral bioavailability of apigenin (AP), a bioactive flavonoid with various pharmacological activities but poor aqueous solubility...
  48. Funakoshi Tago M, Nakamura K, Tago K, Mashino T, Kasahara T. Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin. Int Immunopharmacol. 2011;11:1150-9 pubmed publisher
    ..We therefore focus on flavonoids Apigenin, Luteolin and Fisetin because of their related structure...
  49. Shukla S, MacLennan G, Fu P, Gupta S. Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model. Pharm Res. 2012;29:1506-17 pubmed publisher
    ..We determined the effect of apigenin, a plant flavone, on IGF signaling and its downstream targets in TRAMP mice. Mice received p.o...
  50. Zbidah M, Lupescu A, Jilani K, Fajol A, Michael D, Qadri S, et al. Apigenin-induced suicidal erythrocyte death. J Agric Food Chem. 2012;60:533-8 pubmed publisher
    b>Apigenin, a flavone in fruits and vegetables, stimulates apoptosis and thus counteracts cancerogenesis...
  51. Shen C, Cheng J, Lay H, Wu S, Ni C, Teng C, et al. Cytotoxic apigenin derivatives from Chrysopogon aciculatis. J Nat Prod. 2012;75:198-201 pubmed publisher
    Four new apigenin derivatives, 7-de-O-methylaciculatin, 8-C-?-D-boivinopyranosylapigenin, aciculatinone, and 4'-O-glucosylaciculatin, along with eight known compounds, apigenin-8-carbaldehyde, kaempferol, tricin, taxifolin, 6,7,4'-..
  52. Pinheiro M, Boylan F, Fernandes P. Antinociceptive effect of the Orbignya speciosa Mart. (Babassu) leaves: evidence for the involvement of apigenin. Life Sci. 2012;91:293-300 pubmed publisher
    ..of the ethanol extract (EE) and dichloromethane fraction (DF) obtained from leaves were investigated, as well as apigenin using nociception models (acetic acid-induced abdominal writhing, formalin, and hot plate)...
  53. Gao Z, Huang D, Li H, Zhang L, Lv Y, Cui H, et al. Scutellarin promotes in vitro angiogenesis in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2010;400:151-6 pubmed publisher
    ..Taken together, these results suggest that scutellarin promotes angiogenesis and may form a basis for angiogenic therapy. ..
  54. Hossain M, Banik N, Ray S. N-Myc knockdown and apigenin treatment controlled growth of malignant neuroblastoma cells having N-Myc amplification. Gene. 2013;529:27-36 pubmed publisher
    ..of N-Myc oncogene using short hairpin RNA (shRNA) plasmid to increase anti-tumor efficacy of the isoflavonoid apigenin (APG) in human malignant neuroblastoma SK-N-DZ and SK-N-BE2 cell lines that harbor N-Myc amplification...
  55. Xu Y, Xin Y, Diao Y, Lu C, Fu J, Luo L, et al. Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cells. PLoS ONE. 2011;6:e29169 pubmed publisher
    ..b>Apigenin, a kind of flavonoids, has been reported to possess anticancer activities with very low cytotoxicity to normal ..
  56. Mafuvadze B, Liang Y, Besch Williford C, Zhang X, Hyder S. Apigenin induces apoptosis and blocks growth of medroxyprogesterone acetate-dependent BT-474 xenograft tumors. Horm Cancer. 2012;3:160-71 pubmed publisher
    ..In this study, we sought to determine whether apigenin, a low molecular weight anti-carcinogenic flavonoid, inhibits the growth of aggressive Her2/neu-positive BT-474 ..
  57. Choo C, Sulong N, Man F, Wong T. Vitexin and isovitexin from the Leaves of Ficus deltoidea with in-vivo ?-glucosidase inhibition. J Ethnopharmacol. 2012;142:776-81 pubmed publisher
    ..The leaves of Ficus deltoidea are used as a traditional medicine by diabetes patients in Malaysia...
  58. Shukla S, Bhaskaran N, Babcook M, Fu P, MacLennan G, Gupta S. Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway. Carcinogenesis. 2014;35:452-60 pubmed publisher
    ..b>Apigenin, a naturally occurring plant flavone, exhibits antiproliferative and anticarcinogenic activities through ..
  59. Qian L, Shen M, Tang H, Tang Y, Zhang L, Fu Y, et al. Synthesis and protective effect of scutellarein on focal cerebral ischemia/reperfusion in rats. Molecules. 2012;17:10667-74 pubmed publisher
  60. Henkels K, Frondorf K, Gonzalez Mejia M, Doseff A, Gomez Cambronero J. IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3). FEBS Lett. 2011;585:159-66 pubmed publisher
    ..Further, JAK3 activity and chemotaxis were inhibited by the flavonoid apigenin (4',5,7-trihydroxyflavone) at ?5nM IC(50)...
  61. Zhao L, Wang J, Liu R, Li X, Li J, Zhang L. Neuroprotective, anti-amyloidogenic and neurotrophic effects of apigenin in an Alzheimer's disease mouse model. Molecules. 2013;18:9949-65 pubmed publisher
    ..Amyloid-? peptides (A?) are considered to play a critical role in the onset and progression of AD. Apigenin (4',5,7-trihydroxyflavone) is a pharmacologically active agent...
  62. Seo Y, Kim B, Chun S, Park Y, Kang K, Kwon T. Apoptotic effects of genistein, biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1. J Korean Med Sci. 2011;26:1489-94 pubmed publisher
    ..We investigated the molecular mechanism of these compounds (genistein, biochanin-A and apigenin) in PC-3 (hormone-independent/p53 mutant type) and LNCaP (hormone-dependent/p53 wild type) prostate cancer cells...
  63. Kim J, Sikder M, Lee H, Rahman M, Kim J, Chang G, et al. Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin. Phytother Res. 2012;26:1784-8 pubmed publisher
    In this study, we investigated whether apigenin and wogonin affect MUC5AC mucin production and gene expression induced by phorbol ester (phorbol 12-myristate 13-acetate, PMA) or epidermal growth factor (EGF) from human airway epithelial ..
  64. Silvan S, Manoharan S. Apigenin prevents deregulation in the expression pattern of cell-proliferative, apoptotic, inflammatory and angiogenic markers during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Arch Oral Biol. 2013;58:94-101 pubmed publisher
    ..The present study has investigated the modulating effect of apigenin on expression pattern of apoptotic (p53, Bcl-2, Bax, Caspase-3 and 9) cell proliferative (PCNA, Cyclin D1, c-fos),..
  65. Hojati M, Modarres Sanavy S, Ghanati F, Panahi M. Hexaconazole induces antioxidant protection and apigenin-7-glucoside accumulation in Matricaria chamomilla plants subjected to drought stress. J Plant Physiol. 2011;168:782-91 pubmed publisher
    ..the relative water, protein and proline contents; non-enzymatic and enzymatic antioxidants; and the flower's apigenin-7-glucoside content...
  66. Suh K, Oh S, Woo J, Kim S, Kim J, Kim Y, et al. Apigenin attenuates 2-deoxy-D-ribose-induced oxidative cell damage in HIT-T15 pancreatic ?-cells. Biol Pharm Bull. 2012;35:121-6 pubmed
    ..We investigated whether the flavonoid apigenin protects pancreatic ?-cells from 2-deoxy-D-ribose (dRib)-induced oxidative cell damage...
  67. Han D, Row K. Determination of luteolin and apigenin in celery using ultrasonic-assisted extraction based on aqueous solution of ionic liquid coupled with HPLC quantification. J Sci Food Agric. 2011;91:2888-92 pubmed publisher
    ..7% to 89.5%. Under optimal conditions, compared with conventional solvent extraction amounts of luteolin and apigenin were more than doubled.
  68. Shimada H, Eto M, Ohtaguro M, Ohtsubo M, Mizukami Y, Ide T, et al. Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein. J Biochem Mol Toxicol. 2010;24:230-4 pubmed publisher
    ..Among flavonoids tested, galangin, kaempferol, chrysin, and apigenin were potent inhibitors...
  69. Chen Z, Tu M, Sun S, Kong S, Wang Y, Ye J, et al. The exposure of luteolin is much lower than that of apigenin in oral administration of Flos Chrysanthemi extract to rats. Drug Metab Pharmacokinet. 2012;27:162-8 pubmed
    Luteolin (3',4',5,7-tetrahydroxyflavone) and apigenin (4',5,7-trihydroxyflavone) are two common flavones and major bioactive components in Flos Chrysanthemi extract (FCE). Although FCE contains approximately equal amounts of luteolin (6...
  70. Yamagata K, Tagawa C, Matsufuji H, Chino M. Dietary apigenin regulates high glucose and hypoxic reoxygenation-induced reductions in apelin expression in human endothelial cells. J Nutr Biochem. 2012;23:929-36 pubmed publisher
    ..In addition, we also examined the effects of the dietary flavonoid apigenin on apelin expression. Human endothelial cell lines were treated with HG plus TNF? or subjected to H/R...
  71. Wang S, Wang H, Guo H, Kang L, Gao X, Hu L. Neuroprotection of Scutellarin is mediated by inhibition of microglial inflammatory activation. Neuroscience. 2011;185:150-60 pubmed publisher
  72. Hwang Y, Oh K, Yun H, Jeong H. The flavonoids apigenin and luteolin suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and AP-1-dependent signaling in HaCaT cells. J Dermatol Sci. 2011;61:23-31 pubmed publisher
    ..We investigated the protective effects of apigenin and luteolin on immortalized human keratinocytes (HaCaT) against UVA damage...
  73. Ohno M, Shibata C, Kishikawa T, Yoshikawa T, Takata A, Kojima K, et al. The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice. Sci Rep. 2013;3:2553 pubmed publisher
    Polyphenols are representative bioactive substances with diverse biological effects. Here, we show that apigenin, a flavonoid, has suppressive effects on microRNA (miRNA) function...
  74. Guo H, Hu L, Wang S, Wang Y, Shi F, Li H, et al. Neuroprotective effects of scutellarin against hypoxic-ischemic-induced cerebral injury via augmentation of antioxidant defense capacity. Chin J Physiol. 2011;54:399-405 pubmed publisher
    ..These results suggest that the preventive and therapeutic potential of scutellarin in cerebral injury patients is, at least in part, ascribed to augmentation of cellular antioxidant defense capacity. ..
  75. Tong X, Pelling J. Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention. Anticancer Agents Med Chem. 2013;13:971-8 pubmed
    ..Among them, apigenin, a naturally occurring flavonoid found in a variety of fruits and leafy vegetables, has been shown to possess ..