Summary: A group of 4-keto-FLAVONOIDS.

Top Publications

  1. Dajas F, Andres A, Florencia A, Carolina E, Felicia R. Neuroprotective actions of flavones and flavonols: mechanisms and relationship to flavonoid structural features. Cent Nerv Syst Agents Med Chem. 2013;13:30-5 pubmed
    ..Among the six groups in which flavonoids are classified, the flavones and flavonols, based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one) are the most commonly ..
  2. Liao Z, Wu Z, Wu M. Cirsium japonicum flavones enhance adipocyte differentiation and glucose uptake in 3T3-L1 cells. Biol Pharm Bull. 2012;35:855-60 pubmed
    Cirsium japonicum flavones have been demonstrated to possess anti-diabetic effects in diabetic rats, but the functional mechanism remains unknown...
  3. Narwal M, Koivunen J, Haikarainen T, Obaji E, Legala O, Venkannagari H, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013;56:7880-9 pubmed publisher
    ..b>Flavones have been shown to inhibit tankyrases and we report here the discovery of more potent and selective flavone ..
  4. Klier L, Bresser T, Nigst T, Karaghiosoff K, Knochel P. Lewis acid-triggered selective zincation of chromones, quinolones, and thiochromones: application to the preparation of natural flavones and isoflavones. J Am Chem Soc. 2012;134:13584-7 pubmed publisher
    ..In the absence of MgCl(2), a C(3) zincation is observed, whereas in the presence of MgCl(2) or a related Lewis acid, C(2) zincation occurs. Applications to a natural flavone, isoflavone, and quinolone are shown. ..
  5. Vidyalakshmi K, Kamalakannan P, Viswanathan S, Ramaswamy S. Anti-inflammatory effect of certain dihydroxy flavones and the mechanisms involved. Antiinflamm Antiallergy Agents Med Chem. 2012;11:253-61 pubmed
    ..The effect of dihydroxy flavones on acute inflammation was studied in rats employing carrageenan induced hind paw edema method...
  6. Christensen K, Naidu A, Parent M, Pintos J, Abrahamowicz M, Siemiatycki J, et al. The risk of lung cancer related to dietary intake of flavonoids. Nutr Cancer. 2012;64:964-74 pubmed publisher
    ..We examined associations between intake of 5 flavonoid subclasses (anthocyanidins, flavan-3-ols, flavones, flavonols, and flavanones) and lung cancer risk in a population-based case-control study in Montreal, Canada (..
  7. Jiang M, Peng Q, Liu X, Jin J, Hou Z, Zhang J, et al. Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum Mol Genet. 2013;22:2462-70 pubmed publisher
    ..These data highlight consideration of TrkB as a therapeutic target in HD and suggest that small-molecule TrkB agonists that penetrate the brain have high potential to be further tested in clinical trials of HD. ..
  8. Lucas C, Allen K, Dorward D, Hoodless L, Melrose L, Marwick J, et al. Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway. FASEB J. 2013;27:1084-94 pubmed publisher
    ..Here we investigate the ability of the flavones apigenin, luteolin, and wogonin to induce neutrophil apoptosis in vitro and resolve neutrophilic inflammation in ..
  9. During A, Larondelle Y. The O-methylation of chrysin markedly improves its intestinal anti-inflammatory properties: Structure-activity relationships of flavones. Biochem Pharmacol. 2013;86:1739-46 pubmed publisher
    The aim of this study was to investigate whether methoxylated flavones versus their unmethylated analogs can modulate the intestinal inflammatory response...

More Information


  1. Haid S, Novodomská A, Gentzsch J, Grethe C, Geuenich S, Bankwitz D, et al. A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology. 2012;143:213-22.e5 pubmed publisher
    ..We screened a library of plant-derived small molecules to identify HCV inhibitors with novel mechanisms...
  2. Thomas C, Wood R, Wyatt J, Pendleton M, Torrenegra R, Rodríguez O, et al. Anti-neoplastic activity of two flavone isomers derived from Gnaphalium elegans and Achyrocline bogotensis. PLoS ONE. 2012;7:e39806 pubmed publisher
    ..These flavones are derived from plants of the family Asteraceae, genera Gnaphalium and Achyrocline reputed to have anti-cancer ..
  3. Fukazawa H, Suzuki T, Wakita T, Murakami Y. A cell-based, microplate colorimetric screen identifies 7,8-benzoflavone and green tea gallate catechins as inhibitors of the hepatitis C virus. Biol Pharm Bull. 2012;35:1320-7 pubmed
    ..Other gallate-type catechins and flavones also displayed anti-HCV activity, but 5,6-benzoflavone (?-naphthoflavone), flavanone, and non-gallate catechins ..
  4. Narwal M, Haikarainen T, Fallarero A, Vuorela P, Lehtiö L. Screening and structural analysis of flavones inhibiting tankyrases. J Med Chem. 2013;56:3507-17 pubmed publisher
    ..All identified tankyrase inhibitors were flavones. We report crystal structures of all the hit compounds in complex with the catalytic domain of human tankyrase 2...
  5. de Oliveira A, de Sousa J, da Silva M, Hilário F, Resende F, de Camargo M, et al. Estrogenic and chemopreventive activities of xanthones and flavones of Syngonanthus (Eriocaulaceae). Steroids. 2013;78:1053-63 pubmed publisher
    The possible benefits of some bioactive flavones and xanthones present in plants of the genus Syngonanthus prompted us to screen them for estrogenic activity...
  6. Zeng Y, Liu Y, Wu M, Liu J, Hu Q. Activation of TrkB by 7,8-dihydroxyflavone prevents fear memory defects and facilitates amygdalar synaptic plasticity in aging. J Alzheimers Dis. 2012;31:765-78 pubmed publisher
  7. Ta N, Walle T. Aromatase inhibition by bioavailable methylated flavones. J Steroid Biochem Mol Biol. 2007;107:127-9 pubmed
    ..We have recently shown that methylated flavones, including 5,7-dimethoxyflavone, 7-methoxyflavone and 7,4'-dimethoxyflavone, are much more resistant to ..
  8. Alvim J, Severino R, Marques E, Martinelli A, Vieira P, Fernandes J, et al. Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors. J Comb Chem. 2010;12:687-95 pubmed publisher
    ..In the present work, natural flavonoids were screened against cathepsin V, and two flavones were identified as potent inhibitors of cathepsin V...
  9. Yen J, Weng C, Li S, Lo Y, Pan M, Fu S, et al. Citrus flavonoid 5-demethylnobiletin suppresses scavenger receptor expression in THP-1 cells and alters lipid homeostasis in HepG2 liver cells. Mol Nutr Food Res. 2011;55:733-48 pubmed publisher
    ..It exhibits similar hypolipidemic activity as nobiletin and both can enhance LDL receptor gene expression and activity and decreased acyl CoA:diacylglycerol acyltransferase 2 expression. ..
  10. Lin J, Rexrode K, Hu F, Albert C, Chae C, Rimm E, et al. Dietary intakes of flavonols and flavones and coronary heart disease in US women. Am J Epidemiol. 2007;165:1305-13 pubmed
    Dietary flavonols and flavones are subgroups of flavonoids that have been suggested to decrease the risk of coronary heart disease (CHD)...
  11. Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets. 2010;9:263-85 pubmed
    ..can play a modulating, biphasic and regulatory action on immunity and inflammation; in this context only few flavones and flavonols have been assayed, mainly because of their chemical similarity with quercetin, so evidence reported ..
  12. Feng Y, Li X, Duan X, Wang B. Iridoid glucosides and flavones from the aerial parts of Avicennia marina. Chem Biodivers. 2006;3:799-806 pubmed
    ..Beside that, one known iridoid glucoside, 2'-O-coumaroylmussaenosidic acid (3) and four known flavones (flavone = 2-phenyl-4H-1-benzopyran-4-one) including 4',5-dihydroxy-3',7-dimethoxyflavone (4), 4',5-dihydroxy-3',..
  13. Lai C, Tsai M, Cheng A, Li S, Lo C, Wang Y, et al. Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice. Mol Nutr Food Res. 2011;55:278-90 pubmed publisher
    ..Here we investigated the chemopreventive effects and underlying molecular mechanisms of dietary administration of hydroxylated PMFs in an azoxymethane (AOM)-induced colonic tumorigenesis model...
  14. Lee K, Kim E, Jeon K, Cho S, Han Y, Yang B, et al. 3,4-Dihydroxyflavone acts as an antioxidant and antiapoptotic agent to support bovine embryo development in vitro. J Reprod Dev. 2011;57:127-34 pubmed
    ..These results suggest that 3,4-DHF may promote the in vitro development of bovine embryos through its antioxidant and antiapoptotic effects. ..
  15. Yoon S, Dela Peña I, Shin C, Son K, Lee Y, Ryu J, et al. Convulsion-related activities of Scutellaria flavones are related to the 5,7-dihydroxyl structures. Eur J Pharmacol. 2011;659:155-60 pubmed publisher
    We screened the major bioactive flavones isolated from Scutellaria baicalensis (baicalin, baicalein and oroxylin A) for their convulsion related activities...
  16. Hu Y, Wang H, Ye W, Zhao S. [Flavones from flowers of Sesamum indicum]. Zhongguo Zhong Yao Za Zhi. 2007;32:603-5 pubmed
    ..To investigate the chemical constituents from flowers of Sesamum indicum...
  17. Cao Y, Tan N, Chen J, Zeng G, Ma Y, Wu Y, et al. Bioactive flavones and biflavones from Selaginella moellendorffii Hieron. Fitoterapia. 2010;81:253-8 pubmed publisher
    Three new flavones named 5-carboxymethyl-4',7-dihydroxyflavone (1), its ethyl ester (2) and butyl ester (3) were isolated from the herb Selaginella moellendorffii Hieron., together with ten known compounds...
  18. Zhang J, Subramanian S, Zhang Y, Yu O. Flavone synthases from Medicago truncatula are flavanone-2-hydroxylases and are important for nodulation. Plant Physiol. 2007;144:741-51 pubmed
    b>Flavones are important copigments found in the flowers of many higher plants and play a variety of roles in plant adaptation to stress...
  19. Piccinelli A, García Mesa M, Armenteros D, Alfonso M, Arevalo A, Campone L, et al. HPLC-PDA-MS and NMR characterization of C-glycosyl flavones in a hydroalcoholic extract of Citrus aurantifolia leaves with antiplatelet activity. J Agric Food Chem. 2008;56:1574-81 pubmed publisher
    ..A HPLC-PDA-ESI/MS/MS method has been used for the comprehensive analysis of C-glycosyl flavones in TLL...
  20. Yan S, Wu B, Lin Z, Jin H, Huang J, Yang Y, et al. Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium. Mol Biosyst. 2009;5:1204-13 pubmed publisher
    ..based metabonomics approach was applied to characterize the aging of rats, and the anti-aging effect of total flavones of Epimedium (TFE), a traditional Chinese medicine, has also been investigated...
  21. Ohno S, Hosokawa M, Kojima M, Kitamura Y, Hoshino A, Tatsuzawa F, et al. Simultaneous post-transcriptional gene silencing of two different chalcone synthase genes resulting in pure white flowers in the octoploid dahlia. Planta. 2011;234:945-58 pubmed publisher
    ..Therefore, we concluded that simultaneous siRNA-mediated post-transcriptional gene silencing of redundant CHS genes results in the appearance of pure white color in dahlias. ..
  22. Gohari A, Saeidnia S, Malmir M, Hadjiakhoondi A, Ajani Y. Flavones and rosmarinic acid from Salvia limbata. Nat Prod Res. 2010;24:1902-6 pubmed publisher
    ..A. Meyer grows widely in the north and central parts of the country. Six flavones and rosmarinic acid were isolated from the ethyl acetate and methanol extracts of the flowered aerial parts of S...
  23. Johnson R, Lam M, Punzo A, Li H, Lin B, Ye K, et al. 7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome. J Appl Physiol (1985). 2012;112:704-10 pubmed publisher
    ..Thus although the specific mechanisms are not completely known, 7,8-DHF appears to reduce disease symptoms in Mecp2 mutant mice and may have potential as a therapeutic treatment for RTT patients...
  24. Li G, Wang H, Qin G, Jin M, Tang Q, Sun H, et al. Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. Circulation. 2008;117:2449-57 pubmed publisher
    ..These results indicate that oral acacetin is a promising atrium-selective agent for the treatment of AF. ..
  25. Androutsopoulos V, Li N, Arroo R. The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells. J Nat Prod. 2009;72:1390-4 pubmed publisher
    ..The flavones eupatorin (1) and cirsiliol (2) enhanced CYP1 enzyme activity in a concentration-dependent manner in MCF7 human ..
  26. Torres F, Quintana J, Estevez F. 5,7,3'-trihydroxy-3,4'-dimethoxyflavone-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway. Mol Carcinog. 2010;49:464-75 pubmed publisher
    ..The results suggest that THDF could be useful in the development of novel anticancer agents. ..
  27. Joshi K, Rathos M, Mahajan P, Wagh V, Shenoy S, Bhatia D, et al. P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. Mol Cancer Ther. 2007;6:926-34 pubmed
    ..Thus, the in vitro cellular potency, together with in vivo antitumor activity, confirms the potential of P276-00, a cyclin-dependent kinase inhibitor as an anticancer molecule. ..
  28. Murillo G, Hirschelman W, Ito A, Moriarty R, Kinghorn A, Pezzuto J, et al. Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis. Nutr Cancer. 2007;57:28-37 pubmed
    ..The present study is the first to report the potent anticancer activity of zapotin and suggests a role for zapotin both as a chemopreventive and a chemotherapeutic agent against colon cancer...
  29. Polier G, Ding J, Konkimalla B, Eick D, Ribeiro N, Kohler R, et al. Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. Cell Death Dis. 2011;2:e182 pubmed publisher
    ..In this study, we demonstrate for the first time that wogonin and structurally related natural flavones, for example, apigenin, chrysin and luteolin, are inhibitors of cyclin-dependent kinase 9 (CDK9) and block ..
  30. Zamora Ros R, Knaze V, Lujan Barroso L, Slimani N, Romieu I, Fedirko V, et al. Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort. Br J Nutr. 2011;106:1915-25 pubmed publisher
    Flavonols, flavanones and flavones (FLAV) are sub-classes of flavonoids that exert cardioprotective and anti-carcinogenic properties in vitro and in vivo...
  31. Pang X, Zhao J, Zhang W, Zhuang X, Wang J, Xu R, et al. Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats. J Ethnopharmacol. 2008;117:325-31 pubmed publisher
    The study was designed to investigate the antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L...
  32. Choi D, Maguschak K, Ye K, Jang S, Myers K, Ressler K. Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. Proc Natl Acad Sci U S A. 2010;107:2675-80 pubmed publisher
    ..Moreover, use of site-specific, inducible BDNF deletions shows a powerful mechanism that may further our understanding of the pathophysiology of fear-related disorders. ..
  33. Onoue S, Matsui T, Aoki Y, Ishida H, Nukaya H, Kou K, et al. Self-assembled micellar formulation of chafuroside A with improved anti-inflammatory effects in experimental asthma/COPD-model rats. Eur J Pharm Sci. 2012;45:184-9 pubmed publisher
    ..From these observations, the SAM formulation might be an efficacious approach for enhancing the therapeutic potential of CFA for treatment of inflammatory diseases. ..
  34. Sabatini S, Gosetto F, Manfroni G, Tabarrini O, Kaatz G, Patel D, et al. Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump. J Med Chem. 2011;54:5722-36 pubmed publisher
    ..The same compounds, in combination with ciprofloxacin, were able to completely restore its antibacterial activity against both S. aureus SA-K2378 and SA-1199B, norA-overexpressing strains. ..
  35. Maiti A, Cuendet M, Kondratyuk T, Croy V, Pezzuto J, Cushman M. Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007;50:350-5 pubmed
    ..These data suggest that zapotin merits further investigation as a potential cancer chemopreventive agent...
  36. Li C, Zhou L, Lin G, Zuo Z. Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of radix Scutellariae. J Pharm Biomed Anal. 2009;50:298-306 pubmed publisher
    A simple and efficient HPLC/UV method for the simultaneous determination of six bioactive flavones, namely baicalein, baicalin, wogonin, wogonoside, oroxylin A and oroxylin A-7-O-glucuronide, has been developed and applied for their ..
  37. Morin B, Nichols L, Zalasky K, Davis J, Manthey J, HOLLAND L. The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells. J Nutr. 2008;138:1274-81 pubmed
    ..In previous in vivo studies, polymethoxylated flavones (PMF) reduced plasma cholesterol levels at lower doses than required for flavanones...
  38. Zhang J, Subramanian S, Stacey G, Yu O. Flavones and flavonols play distinct critical roles during nodulation of Medicago truncatula by Sinorhizobium meliloti. Plant J. 2009;57:171-83 pubmed publisher
    ..synthase led to roots deficient for a subset of flavonoids, isoflavonoids (formononetin and biochanin A) and flavones (7,4'-dihydroxyflavone), respectively...
  39. Lamy S, Bédard V, Labbe D, Sartelet H, Barthomeuf C, Gingras D, et al. The dietary flavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression through inhibition of PDGFR-beta phosphorylation. Cancer Prev Res (Phila). 2008;1:452-9 pubmed publisher
    ..In this work, we show that the dietary flavones apigenin and luteolin may interfere with this event through their inhibitory effect on PDGF-dependent ..
  40. Jang S, Liu X, Yepes M, Shepherd K, Miller G, Liu Y, et al. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A. 2010;107:2687-92 pubmed publisher
    ..Thus, 7,8-dihydroxyflavone imitates BDNF and acts as a robust TrkB agonist, providing a powerful therapeutic tool for the treatment of various neurological diseases. ..
  41. Walle T. Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?. Semin Cancer Biol. 2007;17:354-62 pubmed
    ..proliferation of cancer cells, but not normal cells, is inhibited with greater potency than with the unmethylated flavones. Limited mechanistic experiments, such as of effects on cell cycle regulation, indicate that the mechanisms of ..
  42. Matsuzaki K, Miyazaki K, Sakai S, Yawo H, Nakata N, Moriguchi S, et al. Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus. Eur J Pharmacol. 2008;578:194-200 pubmed
    ..These findings suggest that nobiletin probably up-regulates synaptic transmission via the postsynaptic AMPA receptors at least partially by stimulation of PKA-mediated phosphorylation of GluR1 receptor in the hippocampus. ..
  43. Choi S, Ha T, Ahn J, Kim S, Kang K, Hwang I, et al. Estrogenic activities of isoflavones and flavones and their structure-activity relationships. Planta Med. 2008;74:25-32 pubmed
    ..89 and q2 = 0.83). The prediction of estrogenicity with regard to ER beta reveals a positive correlation with the AlogP and Hbond acceptors, and a negative correlation with RadOfGyration (r2 = 0.77 and q2 = 0.72). ..
  44. Ferreres F, Andrade P, Valentao P, Gil Izquierdo A. Further knowledge on barley (Hordeum vulgare L.) leaves O-glycosyl-C-glycosyl flavones by liquid chromatography-UV diode-array detection-electrospray ionisation mass spectrometry. J Chromatogr A. 2008;1182:56-64 pubmed publisher
    ..Their structures have been determined by the study of the ion mass fragmentation which characterizes C-glycosyl flavones and O-glycosyl-C-glycosyl flavones, and differentiates di-O-glycosyl flavones from O-diglycosyl-flavones...
  45. Chang H, Wu Y, Su J, Yeh Y, Yuan S. Protoapigenone, a novel flavonoid, induces apoptosis in human prostate cancer cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase 1/2. J Pharmacol Exp Ther. 2008;325:841-9 pubmed publisher
    ..In conclusion, our results demonstrated protoapigenone suppressed prostate cancer cell growth through the activation of p38 MAPK and JNK1/2, with the potential to be developed as a chemotherapeutic agent for prostate cancer. ..
  46. Si D, Wang Y, Zhou Y, Guo Y, Wang J, Zhou H, et al. Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos. 2009;37:629-34 pubmed publisher
    ..an in vitro investigation of the inhibition of cytochrome P450 (P450) 2C9 by a series of flavonoids made up of flavones (flavone, 6-hydroxyflavone, 7-hydroxyflavone, chrysin, baicalein, apigenin, luteolin, scutellarein, and wogonin) ..
  47. Velozo L, Ferreira M, Santos M, Moreira D, Guimarães E, Emerenciano V, et al. C-glycosyl flavones from Peperomia blanda. Fitoterapia. 2009;80:119-22 pubmed publisher
    The methanol extract from aerial parts of the Peperomia blanda (Piperaceae) yielded two C-glycosyl-flavones. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR, chemical ..
  48. Sun Y, Liu Z, Wang J, Wang Y, Zhu L, Li L. [Reparative isolation and purification of flavones from Pericarpium Citri Reticulatae by high-speed counter-current chromatography]. Se Pu. 2009;27:244-7 pubmed
    Three flavones were prepared, isolated and purified from Pericarpium Citri Reticulatae by high-speed counter-current chromatography (HSCCC)...
  49. Chow J, Huang G, Shen S, Wu C, Lin C, Chen Y. Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells. J Cell Biochem. 2008;103:1394-404 pubmed
    ..six structurally related compounds, including 5-OH, 7-OH, 5,7-diOH, 5,7-diOCH(3), 7,8-diOCH(3), and 7-OCH(3)-8-OH flavones, on apoptosis induction in HL-60 cells...
  50. Hasegawa T, Tanaka A, Hosoda A, Takano F, Ohta T. Antioxidant C-glycosyl flavones from the leaves of Sasa kurilensis var. gigantea. Phytochemistry. 2008;69:1419-24 pubmed publisher
    C-glycosyl flavones, kurilensin A (1) and B (2), together with two known compounds, tricin-4'-O-beta-d-glucopyranoside (3) and tricin-5-O-beta-d-glucopyranoside (4), were isolated from hot-water extracts of the leaves of Sasa kurilensis...
  51. Perez A, Ojeda P, Ojeda L, Salas M, Rivas C, Vera J, et al. Hexose transporter GLUT1 harbors several distinct regulatory binding sites for flavones and tyrphostins. Biochemistry. 2011;50:8834-45 pubmed publisher
    ..hexose transporter GLUT1 activity is blocked by tyrosine kinase inhibitors that include natural products such as flavones and isoflavones and synthetic compounds such as tyrphostins, molecules that are structurally unrelated to the ..
  52. Zhang Q, Zhao X, Wang Z. Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008;46:2042-53 pubmed publisher
    ..In our study, cytotoxic effects of structurally related flavones and flavonols on a human oesophageal adenocarcinoma cell line (OE33) were compared, and the molecular mechanisms ..
  53. Park S, Paik J, Ahn M, Park J, Yoon Y. Biosynthesis of plant-specific flavones and flavonols in Streptomyces venezuelae. J Microbiol Biotechnol. 2010;20:1295-9 pubmed
    ..venezuelae system to the production of more diverse plant polyketides including flavones and flavonols...
  54. Singh R, Wu B, Tang L, Liu Z, Hu M. Identification of the position of mono-O-glucuronide of flavones and flavonols by analyzing shift in online UV spectrum (lambdamax) generated from an online diode array detector. J Agric Food Chem. 2010;58:9384-95 pubmed publisher
    ..In this paper, glucuronide(s) of 36 flavones and flavonols were generated using an in vitro glucuronidation reaction...
  55. Pilatova M, Stupáková V, Varinska L, Sarissky M, Mirossay L, Mirossay A, et al. Effect of selected flavones on cancer and endothelial cells. Gen Physiol Biophys. 2010;29:134-43 pubmed
    ..Apoptosis was confirmed by DNA fragmentation and by staining with annexin V. All three tested flavones inhibited endothelial cell migration after 24 h of incubation at a concentration 100 micromol/l...
  56. Ullmannova V, Popescu N. Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines. Cancer Detect Prev. 2007;31:110-8 pubmed
    ..Alone or in combination with demethylating agents, flavone may be an effective adjunct to chemotherapy in preventing breast cancer metastasis. ..
  57. Lin A, Nakagawa Goto K, Chang F, Yu D, Morris Natschke S, Wu C, et al. First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. J Med Chem. 2007;50:3921-7 pubmed
    ..Among them, 24 showed 2.2-14.2-fold greater cytotoxicity than 1 and naphthyl A-ring analogues remarkably enhanced the activity. ..
  58. Lee Y, Cha B, Saito K, Yamakawa H, Choi S, Yamaguchi K, et al. Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice. Biochem Pharmacol. 2010;79:1674-83 pubmed publisher
  59. Greeff J, Joubert J, Malan S, van Dyk S. Antioxidant properties of 4-quinolones and structurally related flavones. Bioorg Med Chem. 2012;20:809-18 pubmed publisher
    ..was synthesised and displayed moderate to high antioxidant activity when compared to structurally related flavones and quinolines...
  60. Serra H, Mendes T, Bronze M, Simplicio A. Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones. Bioorg Med Chem. 2008;16:4009-18 pubmed publisher
    ..Metabolism of the aglycones was detected with the cell model, more extensively when loading in the apical side. Some of the metabolites were identified as glucuronide conjugates by enzymatic hydrolysis. ..
  61. Shim H, Park J, Paik H, Nah S, Kim D, Han Y. Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation. Mol Cells. 2007;24:95-104 pubmed
  62. Zhang R, Kang K, Piao M, Ko D, Wang Z, Chang W, et al. Preventive effect of 7,8-dihydroxyflavone against oxidative stress induced genotoxicity. Biol Pharm Bull. 2009;32:166-71 pubmed
    ..In conclusion, 7,8-dihydroxyflavone was shown to possess cytoprotective properties against oxidative stress by scavenging intracellular ROS and enhancing Akt activity. ..
  63. Yang J, Wang Y, Bao Y, Guo J. The total flavones from Semen cuscutae reverse the reduction of testosterone level and the expression of androgen receptor gene in kidney-yang deficient mice. J Ethnopharmacol. 2008;119:166-71 pubmed publisher
    To discover the effect of the total flavones from Semen cuscutae (TFSC) on the kidney-yang deficiency male mouse, especially on hormone levels and the androgen receptor (AR) mRNA and protein level in the kidney and testicle...
  64. Walle U, Walle T. Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. Drug Metab Dispos. 2007;35:1985-9 pubmed
    Methoxylated flavones were recently shown to be promising cancer chemopreventive agents...
  65. Ferreres F, Sousa C, Valentão P, Andrade P, Seabra R, Gil Izquierdo A. New C-deoxyhexosyl flavones and antioxidant properties of Passiflora edulis leaf extract. J Agric Food Chem. 2007;55:10187-93 pubmed
  66. Ding J, Polier G, Kohler R, Giaisi M, Krammer P, Li Weber M. Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. J Biol Chem. 2012;287:641-9 pubmed publisher
    ..Here, we show that wogonin and the structurally related natural flavones apigenin and chrysin break TRAIL resistance in HTLV-1-associated ATL by transcriptional down-regulation of c-FLIP,..
  67. Qiu P, Dong P, Guan H, Li S, Ho C, Pan M, et al. Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. Mol Nutr Food Res. 2010;54 Suppl 2:S244-52 pubmed publisher
  68. Miyata Y, Sato T, Imada K, Dobashi A, Yano M, Ito A. A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells. Biochem Biophys Res Commun. 2008;366:168-73 pubmed
  69. Stuetz W, Prapamontol T, Hongsibsong S, Biesalski H. Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines ( Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand. J Agric Food Chem. 2010;58:6069-74 pubmed publisher
    Polymethoxylated flavones (PMFs) and flavanone glycosides (FGs) were analyzed in hand-pressed juice and the peeled fruit of 'Sainampueng' tangerines ( Citrus reticulata Blanco cv. Sainampueng) grown in northern Thailand...
  70. Shamaun S, Rahmani M, Hashim N, Ismail H, Sukari M, Lian G, et al. Prenylated flavones from Artocarpus altilis. J Nat Med. 2010;64:478-81 pubmed publisher
    Six prenylated flavones, including one new compound, were isolated and identified from the stem bark extracts of Artocarpus altilis...
  71. Devi L, Ohno M. 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2012;37:434-44 pubmed publisher
    ..Together, our findings indicate that TrkB activation with systemic 7,8-DHF can ameliorate AD-associated memory deficits, which may be, at least in part, attributable to reductions in BACE1 expression and ?-amyloidogenesis. ..
  72. Pan M, Lai Y, Lai C, Wang Y, Li S, Lo C, et al. 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone induces apoptosis through reactive oxygen species production, growth arrest and DNA damage-inducible gene 153 expression, and caspase activation in human leukemia cells. J Agric Food Chem. 2007;55:5081-91 pubmed
    This study examined the growth inhibitory effects of structurally related polymethoxylated flavones in human cancer cells...
  73. Ryu Y, Ha T, Curtis Long M, Ryu H, Gal S, Park K. Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz. J Enzyme Inhib Med Chem. 2008;23:922-30 pubmed
    Five flavones displaying tyrosinase inhibitory activity were isolated from the stem barks of Morus lhou (S.) Koidz., a cultivated edible plant...
  74. Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H. Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. Biochim Biophys Acta. 2008;1780:819-25 pubmed publisher
    ..We firstly revealed novel pharmacophore features of flavonoids by using cell-free, cell-based and in silico docking studies. These results contribute to the development of new BACE-1 inhibitors for the treatment of AD. ..
  75. Manohar S, Padgaonkar A, Jalota Badhwar A, Rao S, Joshi K. Cyclin-dependent kinase inhibitor, P276-00, inhibits HIF-1? and induces G2/M arrest under hypoxia in prostate cancer cells. Prostate Cancer Prostatic Dis. 2012;15:15-27 pubmed publisher
    ..Given its low toxicity profile, its demonstrated antitumor activity and its potential to inhibit the HIF-1 pathway, P276-00 should be considered as antiangiogenic chemotherapy for prostate cancer. ..
  76. Li S, Pan M, Lai C, Lo C, Dushenkov S, Ho C. Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorg Med Chem. 2007;15:3381-9 pubmed
  77. Cuendet M, Oteham C, Maiti A, Craig B, Cushman M, Moon R, et al. Zapotin prevents mouse skin tumorigenesis during the stages of initiation and promotion. Anticancer Res. 2008;28:3705-9 pubmed
    ..Encouraging results from previous and current in vivo studies warrant further investigation of the chemopreventive activity of zapotin. ..