beta naphthoflavone


Summary: A polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308)

Top Publications

  1. Ireland H, Kemp R, Houghton C, Howard L, Clarke A, Sansom O, et al. Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology. 2004;126:1236-46 pubmed
    ..It has been used here to show that beta-catenin is required for the maintenance of intestinal cell proliferation and is implicated in goblet cell differentiation and enterocyte-matrix attachment. ..
  2. Di Bello D, Vaccaro E, Longo V, Regoli F, Nigro M, Benedetti M, et al. Presence and inducibility by beta-naphthoflavone of CYP1A1, CYP1B1 and phase II enzymes in Trematomus bernacchii, an Antarctic fish. Aquat Toxicol. 2007;84:19-26 pubmed
    ..Obtained results represent an additional contribution to the ecotoxicological characterization of T. bernacchii and further support the use of biomarkers for early detection of chemical pollution in Antarctica. ..
  3. Wilson J, Vijayan M, Kennedy C, Iwama G, Moon T. beta-Naphthoflavone abolishes interrenal sensitivity to ACTH stimulation in rainbow trout. J Endocrinol. 1998;157:63-70 pubmed
  4. Chung Davidson Y, Rees C, Wu H, Yun S, Li W. beta-naphthoflavone induction of CYP1A in brain of juvenile lake trout (Salvelinus namaycush Walbaum). J Exp Biol. 2004;207:1533-42 pubmed
    ..The relationship between transcriptional and translational effects of BNF exposure in the brain of juvenile lake trout is discussed. ..
  5. Teles M, Gravato C, Pacheco M, Santos M. Juvenile sea bass biotransformation, genotoxic and endocrine responses to beta-naphthoflavone, 4-nonylphenol and 17 beta-estradiol individual and combined exposures. Chemosphere. 2004;57:147-58 pubmed
    ..Fish responses to mixtures of xenobiotics are complex and the type of interaction (synergism/potentiation or antagonism) in a particular mixture can vary with the evaluated biological response. ..
  6. Teles M, Oliveira M, Pacheco M, Santos M. Endocrine and metabolic changes in Anguilla anguilla L. following exposure to beta-naphthoflavone--a microsomal enzyme inducer. Environ Int. 2005;31:99-104 pubmed
    ..These results demonstrate that BNF a PAH-like compound alters the normal functioning of the hypothalamo-pituitary-thyroid (HPT) axis in A. anguilla. ..
  7. Olsvik P, Lie K, Saele Ø, Sanden M. Spatial transcription of CYP1A in fish liver. BMC Physiol. 2007;7:12 pubmed
    ..If bulk tissue samples are to be used, one should always check how evenly the target genes are expressed in tissue sections and organs in every study. ..
  8. Gravato C, Santos M. Liver phase I and phase II enzymatic induction and genotoxic responses of beta-naphthoflavone water-exposed sea bass. Ecotoxicol Environ Saf. 2002;52:62-8 pubmed
    ..3 and 0.9 microM BNF. The genotoxic effects measured as EMN and ENA suggest that the balance between the rates of liver BNF reactive and conjugated metabolites seems to be critical. ..
  9. Kasai A, Hiramatsu N, Meng Y, Yao J, Takeda M, Maeda S, et al. DRESSA: biosensing of dioxin and dioxin-like chemicals using secreted alkaline phosphatase. Anal Biochem. 2004;335:73-80 pubmed

More Information

Publications107 found, 100 shown here

  1. LEE M, URSO P. Suppression of T lymphocyte proliferation to antigenic and mitogenic stimuli by Benzo(alpha)pyrene and 2-aminofluorene metabolites. Immunopharmacol Immunotoxicol. 2007;29:425-38 pubmed
    ..These data show that the pathway to the strongest immunosuppressive agents for polycyclic aromatic hydrocarbons and arylamines are divergent and related to metabolism by P450 enzymes. ..
  2. Nishibe Y, Hirata M. Effect of phenobarbital and other model inducers on cytochrome P450 isoenzymes in primary culture of dog hepatocytes. Xenobiotica. 1993;23:681-92 pubmed
    ..In a similar manner, induction of cytochrome P450 PBD-1 (CYP 3A12) by PB was confirmed. ..
  3. Nishimura M, Ueda N, Naito S. Effects of dimethyl sulfoxide on the gene induction of cytochrome P450 isoforms, UGT-dependent glucuronosyl transferase isoforms, and ABCB1 in primary culture of human hepatocytes. Biol Pharm Bull. 2003;26:1052-6 pubmed
    ..5% DMSO. Exposure to rifampicin also reduced CYP3A5 and CYP3A7 mRNA levels for donors 1 and 3 at 0.5% and 2.5% DMSO. In conclusion, a DMSO concentration of 0.1% or less may be appropriate for studying induction after drug exposure...
  4. Lupp A, Hugenschmidt S, Rost M, Muller D. Influence of recipient gender on intrasplenic fetal liver tissue transplants in rats: cytochrome P450-mediated monooxygenase functions. Toxicology. 2004;197:199-212 pubmed
    ..These results further confirm that the P450 system of intrasplenic liver tissue transplants and the respective orthotopic livers is similarly influenced by recipient gender. ..
  5. Bastos V, Pinto L, Lima L, Bastos J. Identification and induction by beta-naphthoflavone of CYP1A1 in liver of the neotropical fish pacu, Piaractus mesopotamicus (Characiformes: characidae). Bull Environ Contam Toxicol. 2004;72:13-20 pubmed
  6. Evanson M, Van Der Kraak G. Stimulatory effects of selected PAHs on testosterone production in goldfish and rainbow trout and possible mechanisms of action. Comp Biochem Physiol C Toxicol Pharmacol. 2001;130:249-58 pubmed
    ..These studies demonstrate that PAHs may function as disruptors of reproductive endocrine function in teleosts through the unexpected effect of enhancing testicular steroidogenesis. ..
  7. Brauze D, Januchowski R, Szyfter K. Differences between rats and mice in induction of 4S beta-naphthoflavone-binding protein expression by treatment with beta-naphthoflavone. J Appl Genet. 2002;43:371-6 pubmed
    ..By contrast, no BNF-binding protein was detected in mice treated with BNF in corn oil as a vehicle or with corn oil itself. ..
  8. Hayashida Y, Kawamura T, Hori e R, Yamashita I. Retionic acid and its receptors are required for expression of aryl hydrocarbon receptor mRNA and embryonic development of blood vessel and bone in the medaka fish, Oryzias latipes. Zoolog Sci. 2004;21:541-51 pubmed
    ..Our results also show that medaka embryos may be useful for screening inhibitors of vascular formation for anti-cancer drugs. ..
  9. Nigro M, Frenzilli G, Scarcelli V, Gorbi S, Regoli F. Induction of DNA strand breakage and apoptosis in the eel Anguilla anguilla. Mar Environ Res. 2002;54:517-20 pubmed
    ..The role of oxidative stress in mediating DNA damage was also discussed. ..
  10. Aluru N, Vijayan M. Brain transcriptomics in response to beta-naphthoflavone treatment in rainbow trout: the role of aryl hydrocarbon receptor signaling. Aquat Toxicol. 2008;87:1-12 pubmed publisher
  11. Lubet R, Yao R, Grubbs C, You M, Wang Y. Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element. Chem Biol Interact. 2009;182:22-8 pubmed publisher
    ..g., quinone reductase) is a surrogate for overall Phase II inducing (antioxidant) and potential anti-tumor activity. ..
  12. Fry J, Hammond A, Jassi K, Bass A, Bruce G, Laughton C, et al. Selectivity of 7-alkoxycoumarins as probe substrates for rat hepatic cytochrome P450 forms is influenced by the substitution pattern on the coumarin nucleus. Xenobiotica. 2004;34:707-22 pubmed
  13. Kim J, Hwang D, Son K, Raisuddin S, Ki J, Lee J, et al. cDNA cloning and expression of a xenobiotic metabolizing cytochrome P4501A (CYP1A) from the yellow catfish, Pelteobagrus fulvidraco (Siluriformes). Environ Toxicol. 2008;23:346-53 pubmed publisher
    ..fulvidraco and offers baseline information for further research related to biomarker use of CYP1A and detoxification strategies of this commercially important fish species. ..
  14. Wang E, Mandakas G, Palamanda J, Lin X, Kumari P, Chu I, et al. Temporal evaluation of CYP mRNA in mice administered with prototypical P450 inducers: comparison with conventional protein/enzyme methods. Drug Chem Toxicol. 2008;31:501-13 pubmed
    ..Based on these results, we concluded that the mRNA approach is a useful tool to monitor CYP induction in mice, particularly when treatment duration is beyond 2 days. ..
  15. Dewa Y, Nishimura J, Jin M, Kawai M, Saegusa Y, Harada T, et al. Molecular expression analysis of beta-naphthoflavone-induced hepatocellular tumors in rats. Toxicol Pathol. 2009;37:446-55 pubmed publisher
    ..These results suggest that enhanced cell proliferation and protection against oxidative stress play an important role in BNF-induced hepatocarcinogenesis in rats. ..
  16. Ohhira S, Matsui H, Watanabe K. Effects of pretreatment with cytochrome P-450 inducers, especially phenobarbital on triphenyltin metabolism and toxicity in hamsters. Toxicology. 1999;137:151-9 pubmed
    ..Especially, based on effects of PB and other CYP inducers, PB induction has a key role in suppressing the diabetogenic action of triphenyltin, i.e. by decreasing triphenyltin accumulation in the hamsters. ..
  17. Brown D, Zhang L, Wen Z, Scott J. Induction of P450 monooxygenases in the German cockroach, Blattella germanica L. Arch Insect Biochem Physiol. 2003;53:119-24 pubmed
    ..There was no significant effect of the other five inducers on any of the monooxygenase parameters we measured. In comparison with other insects, the German cockroach seems unusually refractory to most inducing agents. ..
  18. Qiu H, Su G, Tang X. [Tissue-like cultures of rat hepatocytes in study of phase I and phase II drug metabolism]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006;35:541-6 pubmed
    ..To investigate phase I and phase II enzyme activities in drug metabolism with tissue-like cultures of rat hepatocytes...
  19. Elsherbiny M, Brocks D. The effect of CYP1A induction on amiodarone disposition in the rat. J Pharm Sci. 2010;99:539-48 pubmed publisher
    ..9-, 2.5-, 3.8-, 3.4-, and 2.7-fold, respectively. In both groups of rats, the highest concentrations of AM and DEA were in the lung. Exposure to BNF was shown to increase DEA concentrations in the rat. ..
  20. Bassi A, Ledda S, Penco S, Menini S, Muzio G, Canuto R, et al. Changes of CYP1A1, GST, and ALDH3 enzymes in hepatoma cell lines undergoing enhanced lipid peroxidation. Free Radic Biol Med. 2000;29:1186-96 pubmed
  21. Wang T. beta-naphthoflavone, an inducer of xenobiotic metabolizing enzymes, inhibits firefly luciferase activity. Anal Biochem. 2002;304:122-6 pubmed
  22. Henry E, Gasiewicz T. Agonist but not antagonist ligands induce conformational change in the mouse aryl hydrocarbon receptor as detected by partial proteolysis. Mol Pharmacol. 2003;63:392-400 pubmed
    ..We conclude that agonist ligands initiate structural alteration in AhR that is Arnt-dependent and at least partially involves the ligand-binding/Per-Arnt-Sim domain. ..
  23. LeCluyse E, Ahlgren Beckendorf J, Carroll K, Parkinson A, Johnson J. Regulation of glutathione S-transferase enzymes in primary cultures of rat hepatocytes maintained under various matrix configurations. Toxicol In Vitro. 2000;14:101-15 pubmed
    ..Moreover, the matrix and medium conditions influence both the basal and inducible expression of GST subunits in cultured rat hepatocytes. ..
  24. Godard C, Smolowitz R, Wilson J, Payne R, Stegeman J. Induction of cetacean cytochrome P4501A1 by beta-naphthoflavone exposure of skin biopsy slices. Toxicol Sci. 2004;80:268-75 pubmed
    ..This should prove particularly relevant for these and other protected species that cannot be studied in the laboratory. ..
  25. Koskinen H, Pehkonen P, Vehniäinen E, Krasnov A, Rexroad C, Afanasyev S, et al. Response of rainbow trout transcriptome to model chemical contaminants. Biochem Biophys Res Commun. 2004;320:745-53 pubmed
    ..We performed computer-assisted analyses of Medline abstracts retrieved for each compound, which helped us to indicate the expected and novel findings. ..
  26. Miller K, Assunção M, Dangerfield N, Bandiera S, Ross P. Assessment of cytochrome P450 1A in harbour seals (Phoca vitulina) using a minimally-invasive biopsy approach. Mar Environ Res. 2005;60:153-69 pubmed
    ..The results demonstrate that microsamples collected using minimally-invasive techniques can provide toxicologically-relevant information form marine mammals...
  27. van de Kerkhof E, de Graaf I, de Jager M, Meijer D, Groothuis G. Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies. Drug Metab Dispos. 2005;33:1613-20 pubmed
    ..Therefore, it is a promising tool to study intestinal drug metabolism in human intestine in vitro in the future. ..
  28. Pacheco M, Santos M. Naphthalene and beta-naphthoflavone effects on Anguilla anguilla L. hepatic metabolism and erythrocytic nuclear abnormalities. Environ Int. 2002;28:285-93 pubmed
    ..Concerning genotoxicity, it is hypothesized that ENA response depends on different factors such as the exhaustion of the detoxification process, the balance erythropoiesis/erythrocytic catabolism and the DNA repairing capacity. ..
  29. Bussmann U, Bussmann L, Baranao J. An aryl hydrocarbon receptor agonist amplifies the mitogenic actions of estradiol in granulosa cells: evidence of involvement of the cognate receptors. Biol Reprod. 2006;74:417-26 pubmed
  30. Gravato C, Teles M, Oliveira M, Santos M. Oxidative stress, liver biotransformation and genotoxic effects induced by copper in Anguilla anguilla L.--the influence of pre-exposure to beta-naphthoflavone. Chemosphere. 2006;65:1821-30 pubmed
    ..5 microM Cu in eels pre-exposed to BNF. The oxidative stress and genotoxic effects induced by Cu in eels pre-exposed to BNF revealed that the metal effects are potentiated by previous exposure to BNF. ..
  31. Glockner R, Muller D. Ethoxycoumarin O-deethylation (ECOD) activity in rat liver slices exposed to beta-naphthoflavone (BNF) in vitro. Exp Toxicol Pathol. 1995;47:319-24 pubmed
    ..This decrease was highest in the control group, lowest in the BNF group. We conclude that intact liver slices can be used as a simple tool to investigate in vitro enzyme induction of BNF type. ..
  32. Dey A, Parmar D, Dayal M, Dhawan A, Seth P. Cytochrome P450 1A1 (CYP1A1) in blood lymphocytes evidence for catalytic activity and mRNA expression. Life Sci. 2001;69:383-93 pubmed
  33. Meyer J, Nacci D, Di Giulio R. Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments. Toxicol Sci. 2002;68:69-81 pubmed
    ..Additionally, we investigated the hypothesis that low CYP1A activity (measured as in ovo EROD activity) would correlate to increased survival in Elizabeth River sediment pore water; this hypothesis was not supported by our results...
  34. Umachandran M, Howarth J, Ioannides C. Metabolic and structural viability of precision-cut rat lung slices in culture. Xenobiotica. 2004;34:771-80 pubmed
    ..5. It is concluded that precision-cut rat lung slices, of 600 microm thickness, can be maintained metabolically viable in culture for some 8 h. ..
  35. Livingstone D, Mitchelmore C, Peters L, O Hara S, Shaw J, Chesman B, et al. Development of hepatic CYP1A and blood vitellogenin in eel (Anguilla anguilla) for use as biomarkers in the Thames Estuary, UK. Mar Environ Res. 2000;50:367-71 pubmed
    ..mol. wt. (recognised by antibodies to vitellogenin of Morone saxatilis), but putative vitellogenin could not be detected in A. anguilla from selected sites in the Thames Estuary. ..
  36. Gravato C, Santos M. Juvenile sea bass liver P450, EROD induction, and erythrocytic genotoxic responses to PAH and PAH-like compounds. Ecotoxicol Environ Saf. 2002;51:115-27 pubmed
    ..Despite the low liver P450 content and EROD activity induction by NAPH and B(a)P, their genotoxic potential was higher than that of BNF. ..
  37. Veres Z, Torok G, Toth E, Vereczkey L, Jemnitz K. The spectrum of enzymes involved in activation of 2-aminoanthracene varies with the metabolic system applied. Mutat Res. 2005;586:18-27 pubmed
    ..Our results indicate that identification of mutagenic hazard by use of the Ames test may depend on the metabolic system applied. ..
  38. Fontao F, Barnes L, Kaya G, Saurat J, Sorg O. High susceptibility of Lrig1 sebaceous stem cells to TCDD in mice. Toxicol Sci. 2017;: pubmed publisher
  39. Maria V, Correia A, Santos M. Benzo[a]pyrene and beta-naphthoflavone mutagenic activation by European eel (Anguilla anguilla L.) S9 liver fraction. Ecotoxicol Environ Saf. 2002;53:81-5 pubmed
    ..The same does not apply to low BaP concentrations, where liver S9 induction by BNF is necessary to promote mutagenesis. ..
  40. Han H, Lim M, Lee Y, Kim E, Jeon Y, Lee J. Effects of TCDD and estradiol-17beta on the proliferation and Na+/glucose cotransporter in renal proximal tubule cells. Toxicol In Vitro. 2005;19:21-30 pubmed
    ..In conclusion, TCDD inhibited [(3)H]-thymidine incorporation and alpha-MG uptake, and E(2) blocked TCDDs effects in primary cultured renal proximal tubule cells. ..
  41. Noury P, Geffard O, Tutundjian R, Garric J. Non destructive in vivo measurement of ethoxyresorufin biotransformation by zebrafish prolarva: development and application. Environ Toxicol. 2006;21:324-31 pubmed
    ..The proposed methodology thus allows to perform a simple, sensitive, and reproducible microbiotest for the detection of sublethal concentrations of AhR chemical inducers in environmental samples. ..
  42. Armbrecht H, Lakshmi V, Wickstra J, Hsu F, Zenser T. Metabolism of a heterocyclic amine colon carcinogen in young and old rats. Drug Metab Dispos. 2007;35:633-9 pubmed
    ..Changes in IQ metabolism with age along with altered renal function may contribute to the decreased urinary excretion and increased renal binding of IQ and/or its metabolites seen in the old animals. ..
  43. Iba M, Fung J, Thomas P, Park Y. Constitutive and induced expression by pyridine and beta-naphthoflavone of rat CYP1A is sexually dimorphic. Arch Toxicol. 1999;73:208-16 pubmed
    ..The findings support the involvement of different mechanisms in CYP1A induction by pyridine and betaNF. ..
  44. Kimmett S, Whitney R, Marks G. Isolation of N-vinylprotoporphyrin IX after hepatic cytochrome P450 inactivation by 3-[(arylthio)ethyl]sydnone in chick embryos pretreated with phenobarbital, glutethimide, dexamethasone, and beta-naphthoflavone: differential inhibition of ferrochela. Mol Pharmacol. 1996;49:676-82 pubmed
    ..The finding in the present study that the NA and NB regioisomers of N-vinylPP are equipotent does not support the above proposal. The ring C-substituted (NC) and ring D-substituted (ND) regioisomers of N-vinylPP had low potency. ..
  45. Kaliste Korhonen E, Tuovinen K, Hanninen O. Effect of phenobarbital and beta-naphthoflavone on activities of different rat esterases after paraoxon exposure. Gen Pharmacol. 1998;31:307-12 pubmed
    ..7. The results indicated the great importance of peripheral cholinesterases and carboxylesterases as a detoxifying mechanism of paraoxon. The role of serum paraoxonase was not critical. ..
  46. Lupp A, Danz M, Muller D. Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slices. Toxicology. 2001;161:53-66 pubmed
    ..These results show, that an in vitro induction of phase I enzymes in precision-cut liver slices can be demonstrated also immunohistochemically. ..
  47. Fort D, Rogers R, Paul R, Stover E, Finch R. Optimization of an exogenous metabolic activation system for FETAX. II. Preliminary evaluation. Drug Chem Toxicol. 2001;24:117-27 pubmed
    ..Each of the test materials were found to be developmentally toxic when bioactivated by the mixed MAS. ..
  48. Lupp A, Danz M, Muller D. Evaluation of 2-year-old intrasplenic fetal liver tissue transplants in rats. Cell Transplant. 2003;12:423-38 pubmed
    ..This may be due either to the protection of these transplants by the orthotopic livers or to the different humoral and nerval influences at the ectopic site. ..
  49. Vollrath V, Wielandt A, Iruretagoyena M, Chianale J. Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene. Biochem J. 2006;395:599-609 pubmed
    ..Thus Nrf2 appears to regulate Mrp2 gene expression via an ARE element located at the proximal region of its promoter in response to exposure to xenobiotics. ..
  50. Stegeman J, Woodin B, Singh H, Oleksiak M, Celander M. Cytochromes P450 (CYP) in tropical fishes: catalytic activities, expression of multiple CYP proteins and high levels of microsomal P450 in liver of fishes from Bermuda. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1997;116:61-75 pubmed
    ..These species may be good models for examining the structural, functional and regulatory properties of teleost CYP and the environmental or ecological factors contributing to high levels of expression of CYP in some fishes. ..
  51. Avery M, Meek C, Audus K. The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line. Placenta. 2003;24:45-52 pubmed
    ..These results show that major cytochrome P450 forms present in human placenta are present and inducible in BeWo cells, a potential model for investigation of drug metabolism mechanisms in the human trophoblast. ..
  52. Brauze D. Comparison of the induction of a 4S beta-naphthoflavone-binding protein, cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in beta-naphthoflavone-treated rats. Toxicol Lett. 2004;152:111-6 pubmed
    ..The BNF specific binding to a 4S protein was inhibited by exogenous (BNF) and endogenous (indirubin and indigo) ligands for the aryl hydrocarbon receptor. ..
  53. Itakura T, El Kady M, Mitsuo R, Kaminishi Y. Complementary DNA cloning and constitutive expression of cytochrome P450 1C1 in the gills of carp (Cyprinus carpio). Environ Sci. 2005;12:111-20 pubmed
    ..Northern blot analysis for the liver, intestine, gills, and kidney showed no detectable induced expression but constitutive expression in the gill organs. ..
  54. Nannelli A, Rossignolo F, Tolando R, Rossato P, Longo V, Gervasi P. Effect of beta-naphthoflavone on AhR-regulated genes (CYP1A1, 1A2, 1B1, 2S1, Nrf2, and GST) and antioxidant enzymes in various brain regions of pig. Toxicology. 2009;265:69-79 pubmed publisher
    ..The high expression of metabolic enzymes found in blood-brain interfaces could represent a very important defence toward toxins of CNS. ..
  55. Brauze D, Pawlak A. Kinetics of benzo(a)pyrene hydroxylation at varying concentrations of NADPH and NADH in liver microsomes of nontreated and beta-naphthoflavone-treated C57BL/2 and DBA/2 mice. Acta Biochim Pol. 1988;35:159-68 pubmed
    ..It is suggested that the NADH-specific pathway of electron transport to cytochrome P-450 is necessary for the occurrence of this effect both in NADH- and NADPH supported reaction. ..
  56. Waldren C, Ueno A, Schaeffer B, Wood S, Sinclair P, Doolittle D, et al. Mutant yields and mutational spectra of the heterocyclic amines MeIQ and PhIP at the S1 locus of human-hamster AL cells with activation by chick embryo liver (CELC) co-cultures. Mutat Res. 1999;425:29-46 pubmed
    ..7 Mbp. When appropriate metabolic activation is combined with a target locus, which can detect both small and large chromosomal mutations, both MeIQ and PhIP are significant mutagens and clastogens in repair proficient mammalian cells. ..
  57. Sherratt P, McLellan L, Hayes J. Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents. Biochem Pharmacol. 2003;66:51-61 pubmed
    ..Importantly, dietary compounds can modulate PGE(2) biosynthesis, and this is likely to influence colon tumorigenesis. ..
  58. Goodsaid F, Palamanda J, Montgomery D, Mandakas G, Gu C, Li Z, et al. Assessment of temporal biochemical and gene transcription changes in rat liver cytochrome P450: utility of real-time quantitative RT-PCR. Pharm Res. 2003;20:1373-80 pubmed
  59. Buzukov A, Il asova V, Tabak M, Meirelles N, Degterev I. An ESR and spectrophotometric study of the denitration of nitroheterocyclic drugs by liver homogenates and their metabolic consumption by liver microsomes from cytochrome P-450-induced mice. Chem Biol Interact. 1996;100:113-24 pubmed
    ..Treating the animals with any of the above inducers significantly increased the rate of NHCD metabolism in mouse liver microsomes. Based on these results, a possible mechanism for hepatic NHCD denitration is discussed. ..
  60. Miyazawa M, Sugie A, Shimada T. Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes. Drug Metab Dispos. 2003;31:1049-53 pubmed
  61. Aluru N, Vijayan M. beta-Naphthoflavone disrupts cortisol production and liver glucocorticoid responsiveness in rainbow trout. Aquat Toxicol. 2004;67:273-85 pubmed
    ..Altogether, our results suggest that AhR activation disrupts interrenal corticosteroidogenesis and target tissue responsiveness to glucocorticoid stimulation in rainbow trout. ..
  62. Chatuphonprasert W, Jarukamjorn K, Kondo S, Nemoto N. Synergistic increases of metabolism and oxidation-reduction genes on their expression after combined treatment with a CYP1A inducer and andrographolide. Chem Biol Interact. 2009;182:233-8 pubmed publisher
    ..Synergistic expression of CYP1A1 and CYP1B1 mRNA was confirmed by quantitative RT-PCR. These observations suggest that drug interaction and risk assessment with the use of andrographolide or A. paniculata should be elucidated. ..
  63. Scanarotti C, Bassi A, Catalano M, Guida C, Coradeghini R, Falugi C, et al. Neurogenic-committed human pre-adipocytes express CYP1A isoforms. Chem Biol Interact. 2010;184:474-83 pubmed publisher
    ..We therefore propose the use of pre-adipocytes and their neurogenic derivates to evaluate the cytotoxic/biological effects of unintended exposure to contaminants. ..
  64. Walter R, Ullmann C, Thummler D, Siegmund W. Influence of propiverine on hepatic microsomal cytochrome p450 enzymes in male rats. Drug Metab Dispos. 2003;31:714-7 pubmed
    ..In conclusion, propiverine is a phenobarbital-type inducer on hepatic P450 enzymes in rats in doses about 100-times above the therapeutic doses in man. ..
  65. Bermudez de Leon M, Gomez P, Elizondo G, Zatarain Palacios R, Garcia Sierra F, Cisneros B. Beta-naphthoflavone represses dystrophin Dp71 expression in hepatic cells. Biochim Biophys Acta. 2006;1759:152-8 pubmed
    ..Modulation of Dp71 expression by betaNF may represent a novel mechanism of Ahr action. ..
  66. Dewa Y, Nishimura J, Muguruma M, Jin M, Saegusa Y, Okamura T, et al. beta-Naphthoflavone enhances oxidative stress responses and the induction of preneoplastic lesions in a diethylnitrosamine-initiated hepatocarcinogenesis model in partially hepatectomized rats. Toxicology. 2008;244:179-89 pubmed publisher
    ..These results suggest that the administration of BNF at a high dose and over a long-term enhance oxidative stress responses which may contribute to its hepatocarcinogenic potential in rats. ..
  67. Liu Z, Zeng S. Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat hepatocytes. Toxicol Lett. 2009;187:131-6 pubmed publisher
    ..These findings suggest that HepG2 cells were more sensitive to the cytotoxicity of ginkgolic acid than primary rat hepatocytes, and CYP1A and CYP3A could metabolize ginkgolic acid to more toxic compounds. ..
  68. Di Folco S, Stammati A, Vittozzi L, Zucco F. Studies of cytotoxicity and metabolic competence with the rat intestinal cell line IEC-17. Drug Chem Toxicol. 1990;13:221-8 pubmed
    ..Induction of xenobiotic metabolism by beta-naphthoflavone seems also to elicit the toxicity of 9,10-dimethyl-1,2-benzathracene (DBA) but not that one of cyclophosphamide (CPA). ..
  69. Matthew D, Houston J. Drug metabolizing capacity in vitro and in vivo--I. Correlations between hepatic microsomal monooxygenase markers in beta-naphthoflavone-induced rats. Biochem Pharmacol. 1990;40:743-9 pubmed
    ..8) can be established between in vitro and in vivo markers of hepatic microsomal monooxygenase activity. ..
  70. Rees C, Li W. Development and application of a real-time quantitative PCR assay for determining CYP1A transcripts in three genera of salmonids. Aquat Toxicol. 2004;66:357-68 pubmed
    ..24 x 10(6) (rainbow trout) to 1.05 x 10(7) (brook trout) transcripts microg(-1) total RNA. Mean induced levels of CYP1A expression ranged from 1.07 x 10(8) (lake trout) to 1.05 x 10(9) (brook trout) trancripts microg(-1) total RNA. ..
  71. Eskin S, Turner N, McIntire L. Endothelial cell cytochrome P450 1A1 and 1B1: up-regulation by shear stress. Endothelium. 2004;11:1-10 pubmed
    ..Protein levels of CYP1A1 in HUVECs were up-regulated under shear stress, whereas protein levels of CYP1B1 were not. ..
  72. Sinha A, Muthiah K, Jiang W, Couroucli X, Barrios R, Moorthy B. Attenuation of hyperoxic lung injury by the CYP1A inducer beta-naphthoflavone. Toxicol Sci. 2005;87:204-12 pubmed
    ..Our results showed an inverse correlation between pulmonary and hepatic CYP1A expression and the extent of lung injury, which supports the hypothesis that CYP1A enzyme plays a protective role against oxygen-mediated tissue damage. ..
  73. Tintos A, Gesto M, Míguez J, Soengas J. beta-Naphthoflavone and benzo(a)pyrene treatment affect liver intermediary metabolism and plasma cortisol levels in rainbow trout Oncorhynchus mykiss. Ecotoxicol Environ Saf. 2008;69:180-6 pubmed
    ..Furthermore, beta-NF treatment stimulated amino acid catabolism in liver. These metabolic changes can be associated with increased levels of plasma cortisol, and suggest a different metabolic behavior depending on PAHs. ..
  74. Gesto M, Tintos A, Rodríguez Illamola A, Soengas J, Míguez J. Effects of naphthalene, beta-naphthoflavone and benzo(a)pyrene on the diurnal and nocturnal indoleamine metabolism and melatonin content in the pineal organ of rainbow trout, Oncorhynchus mykiss. Aquat Toxicol. 2009;92:1-8 pubmed publisher
    ..This disruption could be a threat for the survival of the animals in their natural environment, although the increases observed in melatonin levels could play a relevant role as a toxicity-protection factor. ..
  75. Raza H, Agarwal R, Bickers D, Mukhtar H. Purification and molecular characterization of beta-naphthoflavone-inducible cytochrome P-450 from rat epidermis. J Invest Dermatol. 1992;98:233-40 pubmed
    ..These results indicate that rat epidermal P-450 induced by beta-NF is similar to hepatic P-4501A1. ..
  76. Rosenberg D. Dietary modulation of cytochrome P450 in the small intestinal epithelium. Pharmacology. 1991;43:36-46 pubmed
    ..These data underscore the importance of dietary considerations when evaluating studies of xenobiotics that undergo 'first pass' cytochrome P450-dependent metabolism in the small intestine. ..
  77. Sartori E, Delaforge M, Mansuy D. In vitro interaction of rat liver cytochromes P-450 with erythromycin, oleandomycin and erythralosamine derivatives. Importance of structural factors. Biochem Pharmacol. 1989;38:2061-8 pubmed
  78. Watson D, Reichert W, Di Giulio R. Induction of hepatic CYP1A in channel catfish increases binding of 2-aminoanthracene to DNA in vitro and in vivo. Carcinogenesis. 1998;19:1495-501 pubmed
    ..In addition, binding was decreased by the CYP1A inhibitor 3,3',4,4'-tetrachlorobiphenyl. Collectively, these data demonstrate that CYP1A is involved in the activation of AA in channel catfish. ..
  79. Wang H, Williamson G, Peng R. An expressional system of human cytochrome P-450 CYP1A1 gene transcription. Zhongguo Yao Li Xue Bao. 1998;19:429-32 pubmed
    ..The CYP1A1 gene transcriptional system was more reliable and sensitive. ..
  80. Lupp A, Danz M, Muller D, Klinger W. Expression and inducibility of cytochrome P450 isoforms in 1-year-old intrasplenic liver cell transplants in rats. Transpl Int. 2002;15:96-107 pubmed
    ..They have differentiated into adult hepatocytes and even 1 year after transplantation express different P450 isoforms which are inducible by BNF, PB and DEX, corresponding to normal adult liver. ..
  81. Gravato C, Santos M. Beta-naphthoflavone liver EROD and erythrocytic nuclear abnormality induction in juvenile Dicentrarchus labrax L. Ecotoxicol Environ Saf. 2002;52:69-74 pubmed
    ..7, 0.9, and 0.3 microM BNF. Liver somatic index significantly increased after 216 h, whereas ALT activity significantly decreased at 144 and 216 h 2.7 microM BNF exposure. ..
  82. Basu N, Kennedy C, Iwama G. The effects of stress on the association between hsp70 and the glucocorticoid receptor in rainbow trout. Comp Biochem Physiol A Mol Integr Physiol. 2003;134:655-63 pubmed
  83. Martignoni M, de Kanter R, Grossi P, Mahnke A, Saturno G, Monshouwer M. An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR. Chem Biol Interact. 2004;151:1-11 pubmed
    ..The induction profiles (qualitative and quantitative) observed in vivo and in vitro are quite similar. All together, these data demonstrate that liver and intestinal slices are a useful and predictive tool to study CYP induction. ..
  84. Babin M, Casado S, Chana A, Herradón B, Segner H, Tarazona J, et al. Cytochrome P4501A induction caused by the imidazole derivative Prochloraz in a rainbow trout cell line. Toxicol In Vitro. 2005;19:899-902 pubmed
    ..These results indicate that PRO, although its structure is not corresponding to the typical features of CYP1A-inducing AhR ligands, still is able to activate CYP1A expression. ..
  85. Chirulli V, Marvasi L, Zaghini A, Fiorio R, Longo V, Gervasi P. Inducibility of AhR-regulated CYP genes by beta-naphthoflavone in the liver, lung, kidney and heart of the pig. Toxicology. 2007;240:25-37 pubmed
    ..Overall, our results demonstrated a differential expression and regulation of the AhR-mediated CYP genes in liver, lung, kidney and heart of the pig.naphthoflavone. ..
  86. Ladona M, Bujons J, Messeguer A, Ampurdanés C, Morato A, Corbella J. Biotransformation and clearance of 3-(phenylamino)propane-1,2-diol, a compound present in samples related to toxic oil syndrome, in C57BL/6 and A/J mice. Chem Res Toxicol. 1999;12:1127-37 pubmed
    ..These findings are the first reported on PAP metabolism and clearance in mice strains and suggest that PAP can be extensively metabolized in vivo and potential reactive species can be generated. ..
  87. Doi A, Holmes E, Kleinow K. P-glycoprotein in the catfish intestine: inducibility by xenobiotics and functional properties. Aquat Toxicol. 2001;55:157-70 pubmed
  88. Jos A, Segner H, Herradón B, Repetto G, Navas J. Induction of EROD activity by 1-phenylimidazole and beta-naphthoflavone in rainbow trout cultured hepatocytes: a comparative study. Toxicol In Vitro. 2007;21:1307-10 pubmed
    ..The overall similarities in the response of betaNF and PIM to the various inhibitors suggest that both compounds, in apparent contrast to the behaviour of some other imidazole derivatives, induce CYP1A following similar mechanisms. ..
  89. Ishida K, Honda M, Shimizu T, Taguchi M, Hashimoto Y. Stereoselective metabolism of carvedilol by the beta-naphthoflavone-inducible enzyme in human intestinal epithelial Caco-2 cells. Biol Pharm Bull. 2007;30:1930-3 pubmed
    ..The UGT1A subfamily in intestinal epithelial cells may be partly responsible for first-pass (presystemic) metabolism of the drug. ..
  90. Lee B, Hendricks J, Bailey G. Metaplastic pancreatic cells in liver tumors induced by diethylnitrosamine. Exp Mol Pathol. 1989;50:104-13 pubmed
    ..Hepatocarcinogenicity should not be described entirely by hepatocellular events since cholangiolar and metaplastic pancreatic cells can respond associatively to carcinogens and dietary modulators. ..
  91. Srivastava G, Bawden M, Hansen A, May B. Heme may not be a positive regulator of cytochrome-P450 gene expression. Eur J Biochem. 1989;178:689-92 pubmed
  92. Viollon Abadie C, Bigot Lasserre D, Nicod L, Carmichael N, Richert L. Effects of model inducers on thyroxine UDP-glucuronosyl-transferase activity in vitro in rat and mouse hepatocyte cultures. Toxicol In Vitro. 2000;14:505-12 pubmed
    ..1999). The present study thus demonstrates that hepatocyte monolayers are appropriated for the evaluation and inter-species comparison of the effects of xenobiotics on T(4)-UGT activities. ..