Summary: A condition of abnormally low AMNIOTIC FLUID volume. Principal causes include malformations of fetal URINARY TRACT; FETAL GROWTH RETARDATION; GESTATIONAL HYPERTENSION; nicotine poisoning; and PROLONGED PREGNANCY.

Top Publications

  1. De Santis M, Scavo M, Noia G, Masini L, Piersigilli F, Romagnoli C, et al. Transabdominal amnioinfusion treatment of severe oligohydramnios in preterm premature rupture of membranes at less than 26 gestational weeks. Fetal Diagn Ther. 2003;18:412-7 pubmed
    ..and 37 underwent serial transabdominal amnioinfusion with saline every 7 days in case of persistent oligohydramnios. Latency period pPROM delivery, week of delivery (26.0 vs. 22.4, p<0.001), neonatal weight (922 vs...
  2. Chuangsuwanich T, Sunsaneevithayakul P, Muangsomboon K, Limwongse C. Ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome presenting with a large nephrogenic cyst, severe oligohydramnios and hydrops fetalis: a case report and review of the literature. Prenat Diagn. 2005;25:210-5 pubmed
    ..cyst in the right side of abdominal cavity was detected in a fetus of 24 weeks' gestational age with severe oligohydramnios and hydrops fetalis...
  3. Beale J, Tuohy J, McDowell S. Herceptin (trastuzumab) therapy in a twin pregnancy with associated oligohydramnios. Am J Obstet Gynecol. 2009;201:e13-4 pubmed publisher
    ..Limited information is available on the use of herceptin in pregnancy. This case is a twin pregnancy exposed to herceptin until 23 weeks' gestation. One twin had chronic renal failure develop, whereas the other twin did not. ..
  4. Zhu X, Jiang S, Zhu X, Zou S, Wang Y, Hu Y. Expression of aquaporin 1 and aquaporin 3 in fetal membranes and placenta in human term pregnancies with oligohydramnios. Placenta. 2009;30:670-6 pubmed publisher
    To explore the pathophysiology of oligohydramnios, the association between the expression of aquaporin 1 and aquaporin 3 in fetal membranes and placenta and oligohydramnios was investigated...
  5. Kitterman J, Chapin C, Vanderbilt J, Porta N, Scavo L, Dobbs L, et al. Effects of oligohydramnios on lung growth and maturation in the fetal rat. Am J Physiol Lung Cell Mol Physiol. 2002;282:L431-9 pubmed
    b>Oligohydramnios (OH) retards fetal lung growth by producing less lung distension than normal...
  6. Ananth C, Oyelese Y, Srinivas N, Yeo L, Vintzileos A. Preterm premature rupture of membranes, intrauterine infection, and oligohydramnios: risk factors for placental abruption. Obstet Gynecol. 2004;104:71-7 pubmed
    To examine whether preterm premature rupture of membranes (PROM), intrauterine infection, and oligohydramnios are risk factors for placental abruption...
  7. Hao R, Liu H, Xiong Z. [Expression of aquaporin-1 in human oligohydramnios placenta and fetal membranes]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:1130-2 pubmed
    To detect aquaporin-1 mRNA (AQP1) expression in human oligohydramnios placenta and fetal membranes. Placenta and fetal membranes samples were obtained from 5 women with oligohydramnios and 5 with normal amniotic fluid volume...
  8. Park J, Yoon B, Romero R, Moon J, Oh S, Kim J, et al. The relationship between oligohydramnios and the onset of preterm labor in preterm premature rupture of membranes. Am J Obstet Gynecol. 2001;184:459-62 pubmed
    ..4; 95% confidence interval, 1.4-3.9; P<.001). Patients with preterm premature rupture of membranes and an amniotic fluid index of < or = 5 cm are at increased risk for a shorter interval to delivery. ..
  9. Bajoria R, Ward S, Chatterjee R. Brain natriuretic peptide and endothelin-1 in the pathogenesis of polyhydramnios-oligohydramnios in monochorionic twins. Am J Obstet Gynecol. 2003;189:189-94 pubmed
    ..of human brain natriuretic peptide and endothelin-1 were highest in the twins with polyhydramnios and lowest in the twins with oligohydramnios, which suggests the importance of these hormones in the regulation of amniotic fluid volume.

More Information


  1. Geary C, Whitsett J. Inhaled nitric oxide for oligohydramnios-induced pulmonary hypoplasia: a report of two cases and review of the literature. J Perinatol. 2002;22:82-5 pubmed
    ..a male born at 29(4/7) weeks' gestational age after an 8-week period of rupture of membranes (ROM) and severe oligohydramnios, and a female infant born at 31 weeks' gestational age after an 18-week period of ROM and severe ..
  2. Locatelli A, Vergani P, Toso L, Verderio M, Pezzullo J, Ghidini A. Perinatal outcome associated with oligohydramnios in uncomplicated term pregnancies. Arch Gynecol Obstet. 2004;269:130-3 pubmed
    In high-risk pregnancies, oligohydramnios is frequently used to identify fetuses at risk of an adverse outcome...
  3. Kim B, Romero R, Mi Lee S, Park C, Shin Park J, Jun J, et al. Clinical significance of oligohydramnios in patients with preterm labor and intact membranes. J Perinat Med. 2011;39:131-6 pubmed publisher
    To determine the frequency and clinical significance of oligohydramnios in patients with preterm labor and intact membranes...
  4. Brace R, Anderson D, Cheung C. Fetal swallowing as a protective mechanism against oligohydramnios and polyhydramnios in late gestation sheep. Reprod Sci. 2013;20:326-30 pubmed publisher
    ..With deviations in AF volume from normal, changes in fetal swallowing protect against oligohydramnios and polyhydramnios because the changes in swallowing over time reduce the extent of the AF volume change...
  5. Lacoste M, Cai Y, Guicharnaud L, Mounier F, Dumez Y, Bouvier R, et al. Renal tubular dysgenesis, a not uncommon autosomal recessive disorder leading to oligohydramnios: Role of the Renin-Angiotensin system. J Am Soc Nephrol. 2006;17:2253-63 pubmed
    ..fetuses and characterized by the absence or poor development of proximal tubules, early onset and persistent oligohydramnios that leads to the Potter sequence, and skull ossification defects...
  6. Awad N, Jordan T, Mundle R, Farine D. Management and Outcome of Reduced Fetal Movements-is Ultrasound Necessary?. J Obstet Gynaecol Can. 2018;40:454-459 pubmed publisher
    ..to discharge, whereas in the other (level 2), only patients with a non-reactive non-stress test (NST) and/or oligohydramnios or intrauterine growth restriction (IUGR) underwent a BPP...
  7. Alchalabi H, Obeidat B, Jallad M, Khader Y. Induction of labor and perinatal outcome: the impact of the amniotic fluid index. Eur J Obstet Gynecol Reprod Biol. 2006;129:124-7 pubmed
    ..Patients were divided into two groups based on their AFI: the oligohydramnios group with AFI < or = 5 cm (n = 66) and a normal group with AFI > 5 cm (n = 114)...
  8. Jakobovits A, Jakobovits A. [Fetal urology]. Orv Hetil. 2009;150:1121-7 pubmed
    ..Presence of these associated intrauterine defects makes early pregnancy termination a management alternative, as well as it affects favorably perinatal mortality rates. ..
  9. Chhabra S, Dargan R, Nasare M. Antepartum transabdominal amnioinfusion. Int J Gynaecol Obstet. 2007;97:95-9 pubmed
    ..of antepartum transabdominal amnioinfusion (APTA) in reducing perinatal morbidity and mortality due to oligohydramnios. In this case-control study of 100 pregnant women with oligohydramnios, 50 received APTA and 50 were treated ..
  10. Chen C, Chou H, Wang L, Lang Y. Experimental oligohydramnios decreases collagen in hypoplastic fetal rat lungs. Exp Biol Med (Maywood). 2008;233:1334-40 pubmed publisher
    Neonates with premature rupture of the membrane and oligohydramnios have an increased risk of acute respiratory morbidity...
  11. Chauhan S, Scardo J, Hendrix N, Magann E, Morrison J. Accuracy of sonographically estimated fetal weight with and without oligohydramnios. A case-control study. J Reprod Med. 1999;44:969-73 pubmed
    To determine the accuracy of sonographically estimated fetal weight among women with and without oligohydramnios (amniotic fluid index [AFI] < or = 5...
  12. Pásztor N, Sikovanyecz J, Kereszturi A, Kozinszky Z, Nemeth G. Evaluation of the relation between placental weight and placental weight to foetal weight ratio and the causes of stillbirth: a retrospective comparative study. J Obstet Gynaecol. 2017;:1-7 pubmed publisher
    ..037, respectively), whereas a similar trend was not observed in the non-FGR pregnancies complicated by PE. Oligohydramnios was accompanied by lower foetal weight compared to those who had normal amount of amniotic fluid (650 grams ..
  13. Biri A, Karaoguz M, Ince G, Ergun M, Menevse S, Bingol B. Double aneuploidy involving trisomy 7 with Potter sequence. Eur J Med Genet. 2005;48:67-73 pubmed
    ..This is the first reported case of double aneuploidy involving trisomy 7 with the features of Potter syndrome. ..
  14. Sivabalasubramaniam G, Sagili H, Dasari P, Gowda M. Burst abdomen: an unusual complication of silicosis in pregnancy. BMJ Case Rep. 2015;2015: pubmed publisher
    ..She was referred to our hospital at 42 weeks of gestation with breathlessness and oligohydramnios. She had worked in a glass and talc powder factory for 11 years and was diagnosed as having silicosis 2 years ..
  15. García V D, Aragón V C, Treviño A M, Rivera S G. [Femoral hypoplasia-unusual facies syndrome: A case report]. Rev Chil Pediatr. 2016;87:59-62 pubmed publisher
    ..this syndrome has been associated with maternal diabetes, drug exposure, viral infections, radiation, and oligohydramnios. The case of a newborn with this syndrome is presented...
  16. Akhtar R, Humayun Y. Sirenomelia. J Coll Physicians Surg Pak. 2010;20:343-4 pubmed publisher
    ..Pre-natal ultrasound showed a cyst in the left kidney and high resistive index (RI) of the fetal umbilical artery along with anhydramnios. Recent literature describes and discusses, the ante-natal diagnostic investigations. ..
  17. GrincevičienÄ— Å, Volochovič J, Grincevičius J. Lack of pharmacist-physician communication associated with nimesulide-induced oligohydramnios during pregnancy. Int J Clin Pharm. 2016;38:196-8 pubmed publisher
    ..In this report, we describe the case of a pregnant woman who developed oligohydramnios after taking nimesulide for neuropathic pain...
  18. Kuo K, Caughey A. Contemporary outcomes of sickle cell disease in pregnancy. Am J Obstet Gynecol. 2016;215:505.e1-5 pubmed publisher
    ..Maternal outcomes of interest included preeclampsia, preterm delivery, placental abruption, oligohydramnios, and cesarean delivery; neonatal outcomes included small for gestational age, anomalies, stillbirth, neonatal ..
  19. Shirakawa T, Kondoh T, Takahashi R, Nakayama M, Kusumoto T, Matsudaira M, et al. Renal tubular dysgenesis complicated with severe cranium hypoplasia. Pediatr Int. 2004;46:88-90 pubmed
  20. Taneja A, Arora K, Chopra I, Naik S. Pregnancy Outcomes in Isolated Oligohydramnios during Second Trimester: A Case Series. J Clin Diagn Res. 2017;11:QR01-QR02 pubmed publisher
    b>Oligohydramnios is associated with increased maternal and foetal morbidities. However, some of the recent studies have shown no adverse effect of isolated oligohydramnios on perinatal outcome and recommends continuation of pregnancy...
  21. Chauhan S, Magann E, Morrison J, Whitworth N, Hendrix N, Devoe L. Ultrasonographic assessment of amniotic fluid does not reflect actual amniotic fluid volume. Am J Obstet Gynecol. 1997;177:291-6; discussion 296-7 pubmed
    ..of amniotic fluid assessment (two-diameter amniotic fluid pocket versus the amniotic fluid index) to predict oligohydramnios (actual amniotic fluid volume < 500 ml) or polyhydramnios (actual amniotic fluid volume > 1500 ml).
  22. Romero Gutiérrez G, Herrera Coria J, Ruiz Treviño A. [Association of Doppler flowmetry with perinatal outcome in patients with oligohydramnios]. Rev Med Inst Mex Seguro Soc. 2014;52:510-5 pubmed
    b>Oligohydramnios is sometimes associated with poor perinatal outcome. Our aim was to determine the association of Doppler flowmetry with perinatal outcome in patients with oligohydramnios...
  23. Astudillo R, Suy A, Alijotas Reig J, Carreras E, Llurba E, Goya M, et al. Expectant management in pregnant women with early and severe preeclampsia and concomitant risk factors. Pregnancy Hypertens. 2013;3:235-41 pubmed publisher
    ..e. associated medical conditions, HELLP syndrome, severe oligohydramnios, fetal growth restriction and multiple pregnancies (group A) and those without (group B)...
  24. De Bernardo G, Giordano M, Di Toro A, Sordino D, De Brasi D. Prenatal diagnosis of Fraser syndrome: a matter of life or death?. Ital J Pediatr. 2015;41:86 pubmed publisher
    ..The prenatal ultrasound can reveal features like polyhydramnios or oligohydramnios, echogenic lungs, renal abnormalities or agenesis and cryptophthalmos that are pathognomonic of the Fraser ..
  25. Brunetti Pierri N, Mian A, Luetchke R, Graham B. Intrauterine growth retardation and placental vacuolization as presenting features in a case of GM1 gangliosidosis. J Inherit Metab Dis. 2007;30:823 pubmed
    ..placental examination was prompted by the prenatal detection of intrauterine growth retardation (IUGR) and oligohydramnios at 32 weeks of gestation...
  26. Locatelli A, Zagarella A, Toso L, Assi F, Ghidini A, Biffi A. Serial assessment of amniotic fluid index in uncomplicated term pregnancies: prognostic value of amniotic fluid reduction. J Matern Fetal Neonatal Med. 2004;15:233-6 pubmed
    ..The aims of our study were to determine whether oligohydramnios and the trend in amniotic fluid volume have prognostic significance in low-risk pregnancies between 40...
  27. Brown W, Wisniewski K, Sudhalter V, Keogh M, Tsiouris J, Miezejeski C, et al. Identical twins discordant for Sotos syndrome. Am J Med Genet. 1998;79:329-33 pubmed
    ..Our finding of discordance in these identical twins suggests that a postconceptual mutation, or epigenetic change and/or an environmental factor may be involved in the cause of Sotos syndrome. ..
  28. Suffia C, Sorrentino S, Vetrella S, Bifano D, Nantron M, De Bernardi B, et al. Neuroblastoma presenting with symptoms of epidural compression at birth: a case report. Ital J Pediatr. 2016;42:52 pubmed publisher
    ..born at the 36(th) week of pregnancy by caesarian section decided following ultrasonographic discovery of oligohydramnios. At birth, she was noted to have motor deficit involving both legs and continuous urinary dripping...
  29. Kozelj M, Novak Antolic Z, Grad A, Peternel P. Patent foramen ovale as a potential cause of paradoxical embolism in the postpartum period. Eur J Obstet Gynecol Reprod Biol. 1999;84:55-7 pubmed
    ..Echocardiography with contrast medium confirmed the patent foramen ovale (PFO). PFO may be a mechanism of paradoxical embolism causing a transient ischemic attack or stroke. ..
  30. Costedoat Chalumeau N, Guettrot Imbert G, Leguern V, Leroux G, Le Thi Huong D, Wechsler B, et al. [Pregnancy and antiphospholipid syndrome]. Rev Med Interne. 2012;33:209-16 pubmed publisher
    ..WG because of severe pre-eclampsia, eclampsia or placental adverse outcomes (intrauterine growth retardation, oligohydramnios)...
  31. Hilliard N, Hawkes R, Patterson A, Graves M, Priest A, Hunter S, et al. Amniotic fluid volume: Rapid MR-based assessment at 28-32 weeks gestation. Eur Radiol. 2016;26:3752-9 pubmed publisher
    ..ages are required this approach could form part of MR fetal assessment, particularly where poly- or oligohydramnios is suspected. • MR projection hydrography can be used to estimate amniotic fluid volume...
  32. Rosier van Dunné F, van Wezel Meijler G, Bakker M, Odendaal H, de Vries J. Fetal general movements and brain sonography in a population at risk for preterm birth. Early Hum Dev. 2010;86:107-11 pubmed publisher
    ..Abnormal GMs correlated with oligohydramnios (p=0.002) and hypertensive disorders (p=0.015)...
  33. Uga N, Ishii T, Kawase Y, Arai H, Tada H. Nitric oxide inhalation therapy in very low-birthweight infants with hypoplastic lung due to oligohydramnios. Pediatr Int. 2004;46:10-4 pubmed
    ..A retrospective comparative study of very low-birthweight infants with pulmonary hypoplasia due to oligohydramnios who had or had not been treated with iNO therapy, was performed (iNO-treated group, eight infants; control ..
  34. Chauhan S, Doherty D, Magann E, Cahanding F, Moreno F, Klausen J. Amniotic fluid index vs single deepest pocket technique during modified biophysical profile: a randomized clinical trial. Am J Obstet Gynecol. 2004;191:661-7; discussion 667-8 pubmed
    ..Significantly more patients were identified as having oligohydramnios using AFI (17%) compared with using 2 x 1 pocket (10%) ( P =.002)...
  35. Tanahashi H, Tian Q, Hara Y, Sakagami H, Endo S, Suzuki T. Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. Sci Rep. 2016;6:20241 pubmed publisher
    ..Bilateral renal agenesis and/or obstruction of the urinary tract lead to oligohydramnios, which causes infant death within a short period after birth due to pulmonary hypoplasia...
  36. Chen C, Lee C, Chen W, Wang W, Tzen C. Prenatal diagnosis of premature centromere division-related mosaic variegated aneuploidy. Prenat Diagn. 2004;24:19-25 pubmed
    ..amniocentesis at 22 weeks' gestation because of intrauterine growth restriction (IUGR), microcephaly, and oligohydramnios. Amniocentesis revealed PCD-related MVA...
  37. Spaggiari E, Heidet L, Grange G, Guimiot F, Dreux S, Delezoide A, et al. Prognosis and outcome of pregnancies exposed to renin-angiotensin system blockers. Prenat Diagn. 2012;32:1071-6 pubmed publisher
    ..Of the 21 fetuses, only one had a normal postnatal renal function at birth (oligohydramnios regression and normal ?2-microglobulin)...
  38. Landau D, Shalev H, Shulman H, Barki Y, Maor E, Zmora E. Oligohydramnion, renal failure and no pulmonary hypoplasia in glomerulocystic kidney disease. Pediatr Nephrol. 2000;14:319-21 pubmed
  39. Kallapur S, Ikegami M. Physiological consequences of intrauterine insults. Paediatr Respir Rev. 2006;7:110-6 pubmed
    ..The information derived from clinical studies is juxtaposed with data from animal experiments to discuss the physiological consequences of intrauterine insults on fetal lung growth. ..
  40. Shioji M, Fukuda H, Kanzaki T, Wasada K, Kanagawa T, Shimoya K, et al. Reduction of aquaporin-8 on fetal membranes under oligohydramnios in mice lacking prostaglandin F2 alpha receptor. J Obstet Gynaecol Res. 2006;32:373-8 pubmed
    ..the association between aquaporin-8 (AQP-8: a water channel protein) expression in fetal membranes and oligohydramnios during near-term and postdate pregnancy, we set up an oligohydramnios model using prostaglandin F2 alpha ..
  41. Cobo T, Borrell A, Fortuny A, Hernandez S, Perez M, Palacio M, et al. Treatment with amniopatch of premature rupture of membranes after first-trimester chorionic villus sampling. Prenat Diagn. 2007;27:1024-7 pubmed
    ..2004, the amniopatch procedure was offered in cases of premature rupture of membranes after CVS when severe oligohydramnios was present (largest vertical pocket < 2 cm) and persistent (more than 1 week)...
  42. Bassler D, Choong K, McNamara P, Kirpalani H. Neonatal persistent pulmonary hypertension treated with milrinone: four case reports. Biol Neonate. 2006;89:1-5 pubmed
    ..However, of 4 patients, 2 developed serious intraventricular hemorrhages (IVHs), and 1 had a small IVH. To clarify the risk benefit ratio, of death versus survival with impairment, a randomized controlled trial is needed. ..
  43. Bullo M, Tschumi S, Bucher B, Bianchetti M, Simonetti G. Pregnancy outcome following exposure to angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists: a systematic review. Hypertension. 2012;60:444-50 pubmed publisher
    ..0001). Neonatal complications were more frequent following exposure to ARBs and included renal failure, oligohydramnios, death, arterial hypotension, intrauterine growth retardation, respiratory distress syndrome, pulmonary ..
  44. Aggarwal S, Kumar A. Fetal hydrocolpos leading to Pierre Robin sequence: an unreported effect of oligohydramnios sequence. J Perinatol. 2003;23:76-8 pubmed
    ..developed gradually because of direct compression of hydrocolpos on bilateral lower ureters, resulting in oligohydramnios from decreased urine formation...
  45. Williams O, Hutchings G, Hubinont C, Debauche C, Greenough A. Pulmonary effects of prolonged oligohydramnios following mid-trimester rupture of the membranes--antenatal and postnatal management. Neonatology. 2012;101:83-90 pubmed publisher
    Mid-trimester, preterm prelabour rupture of the membranes (PPROM) with prolonged oligohydramnios remains a challenge for both obstetricians and neonatologists...
  46. Manzanares S, Carrillo M, González Perán E, Puertas A, Montoya F. Isolated oligohydramnios in term pregnancy as an indication for induction of labor. J Matern Fetal Neonatal Med. 2007;20:221-4 pubmed
    To evaluate the outcome of active induction of labor for isolated oligohydramnios in low-risk term gestation...
  47. Meyberg Solomayer G, Fehm T, Mackensen Haen S, Wallwiener D, Solomayer E. Hemodynamic changes with phenotype reversal during pregnancy in twin-twin transfusion syndrome. Prenat Diagn. 2004;24:816-21 pubmed
    ..The recipient did very well and was discharged 8 weeks later from the neonatology unit. This atypical course shows the importance of serial sonographic monitoring in pregnancies with TTTS. ..
  48. Magann E, Haas D, Hill J, Chauhan S, Watson E, Learman L. Oligohydramnios, small for gestational age and pregnancy outcomes: an analysis using precise measures. Gynecol Obstet Invest. 2011;72:239-44 pubmed publisher
    ..are more likely in pregnancies complicated by small-for-gestational-age (SGA) neonates and dye-determined oligohydramnios. Admissions to neonatal intensive care unit (NICU) and other pregnancy outcomes were analyzed in parturients ..
  49. Kundu A, Chattopadhyay P, Kundu S, Choudhury S. Pregnancy in Ehlers-Danlos syndrome. J Assoc Physicians India. 2006;54:938 pubmed
  50. Zlatnik M, Olson G, Bukowski R, Saade G. Amniotic fluid index measured with the aid of color flow Doppler. J Matern Fetal Neonatal Med. 2003;13:242-5 pubmed
    ..Upper centiles were also different. The AFI measured using color flow Doppler overestimates oligohydramnios and may underestimate polyhydramnios when a standard AFI table obtained without color flow Doppler is used...
  51. Liu R, Chen X, Yang X, Ma H. Prenatal diagnosis of sirenomelia by two-dimensional and three-dimensional skeletal imaging ultrasound. J Huazhong Univ Sci Technolog Med Sci. 2015;35:928-931 pubmed publisher
    ..Initial 2D-US showed that there were 10 cases of oligohydramnios, bilateral renal agenesis, bladder agenesis, single umbilical artery, fusion of the lower limbs and spinal ..
  52. Witzel I, Muller V, Harps E, Janicke F, Dewit M. Trastuzumab in pregnancy associated with poor fetal outcome. Ann Oncol. 2008;19:191-2 pubmed
  53. Gersak K, Cvijic M, Cerar L. Angiotensin II receptor blockers in pregnancy: a report of five cases. Reprod Toxicol. 2009;28:109-12 pubmed publisher
    ..Other two pregnancies were complicated with oligohydramnios and ended in preterm delivery. One preterm infant had transient abnormal renal function tests...