chorioamnionitis

Summary

Summary: INFLAMMATION of the placental membranes (CHORION; AMNION) and connected tissues such as fetal BLOOD VESSELS and UMBILICAL CORD. It is often associated with intrauterine ascending infections during PREGNANCY.

Top Publications

  1. Been J, Degraeuwe P, Kramer B, Zimmermann L. Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis. BJOG. 2011;118:113-22 pubmed publisher
    ..the safety and efficacy of antenatal steroids in preterm labour with suspected intrauterine infection (chorioamnionitis)...
  2. Prendergast M, May C, Broughton S, Pollina E, Milner A, Rafferty G, et al. Chorioamnionitis, lung function and bronchopulmonary dysplasia in prematurely born infants. Arch Dis Child Fetal Neonatal Ed. 2011;96:F270-4 pubmed publisher
    To determine whether prematurely born infants exposed to chorioamnionitis compared to those not exposed have poorer lung function and are more likely to develop severe bronchopulmonary dysplasia (BPD)...
  3. Kim C, Romero R, Kusanovic J, Yoo W, Dong Z, Topping V, et al. The frequency, clinical significance, and pathological features of chronic chorioamnionitis: a lesion associated with spontaneous preterm birth. Mod Pathol. 2010;23:1000-11 pubmed publisher
    Acute chorioamnionitis is a well-established lesion of the placenta in cases with intra-amniotic infection. In contrast, the clinicopathological significance of chronic chorioamnionitis is unclear...
  4. Lee S, Lee K, Kim S, Park C, Yoon B. The risk of intra-amniotic infection, inflammation and histologic chorioamnionitis in term pregnant women with intact membranes and labor. Placenta. 2011;32:516-21 pubmed publisher
    ..an increased risk of microbial invasion of the amniotic cavity, intra-amniotic inflammation and histologic chorioamnionitis. This study was performed to determine when the risk of intra-amniotic infection, inflammation and histologic ..
  5. Knox C, Dando S, Nitsos I, Kallapur S, Jobe A, Payton D, et al. The severity of chorioamnionitis in pregnant sheep is associated with in vivo variation of the surface-exposed multiple-banded antigen/gene of Ureaplasma parvum. Biol Reprod. 2010;83:415-26 pubmed publisher
    ..005), and ureaplasma titers were inversely related to the number of variants (P = 0.025). The severity of chorioamnionitis varied between animals...
  6. Jobe A. The new bronchopulmonary dysplasia. Curr Opin Pediatr. 2011;23:167-72 pubmed publisher
    ..Correlations of BPD with chorioamnionitis are clouded by the complexity of the fetal exposures to inflammation...
  7. Redline R. Inflammatory response in acute chorioamnionitis. Semin Fetal Neonatal Med. 2012;17:20-5 pubmed publisher
    Acute chorioamnionitis is the principal antecedent of premature birth and an important contributor to specific neonatal and other complications that may extend throughout subsequent life...
  8. Gulati S, Bhatnagar S, Raghunandan C, Bhattacharjee J. Interleukin-6 as a predictor of subclinical chorioamnionitis in preterm premature rupture of membranes. Am J Reprod Immunol. 2012;67:235-40 pubmed publisher
    ..clinicians in preterm premature rupture of the membranes (PPROM) is to correctly identify when a significant chorioamnionitis is evolving and decide timely delivery of the fetus...
  9. Torricelli M, Novembri R, Bloise E, De Bonis M, Challis J, Petraglia F. Changes in placental CRH, urocortins, and CRH-receptor mRNA expression associated with preterm delivery and chorioamnionitis. J Clin Endocrinol Metab. 2011;96:534-40 pubmed publisher
    ..Placentas were obtained from spontaneous PTD; premature rupture of membranes (pPROM) and pPROM with chorioamnionitis. Placental specimens were collected from women receiving perinatal care at our Division of Obstetrics and ..

More Information

Publications81

  1. Burd I, Brown A, Gonzalez J, Chai J, Elovitz M. A mouse model of term chorioamnionitis: unraveling causes of adverse neurological outcomes. Reprod Sci. 2011;18:900-7 pubmed publisher
    Maternal fever and/or chorioamnionitis at term are associated with an increased prevalence of adverse neurobehavioral outcomes in exposed offspring...
  2. Czikk M, McCarthy F, Murphy K. Chorioamnionitis: from pathogenesis to treatment. Clin Microbiol Infect. 2011;17:1304-11 pubmed publisher
    b>Chorioamnionitis refers to inflammation of the amniochorionic membrane, and is a significant cause of maternal and neonatal morbidity...
  3. Westover A, Hooper S, Wallace M, Moss T. Prostaglandins mediate the fetal pulmonary response to intrauterine inflammation. Am J Physiol Lung Cell Mol Physiol. 2012;302:L664-78 pubmed publisher
    ..Nimesulide decreased surfactant protein (SP)-A (P = 0.05), -B (P = 0.05), and -D (P = 0.0015) but increased SP-C mRNA (P = 0.023). Thus PGHS-2 mediates, at least in part, fetal pulmonary responses to inflammation. ..
  4. Torricelli M, Voltolini C, Novembri R, Bocchi C, Di Tommaso M, Severi F, et al. Activin A and its regulatory molecules in placenta and fetal membranes of women with preterm premature rupture of the membranes associated with acute chorioamnionitis. Am J Reprod Immunol. 2012;68:392-9 pubmed publisher
    ..in placenta/fetal membranes from preterm premature rupture of membranes (pPROM) associated with acute chorioamnionitis (ACA)...
  5. Buhimschi I, Buhimschi C. The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis. Clin Perinatol. 2010;37:355-74 pubmed publisher
    ..Discovery of clinically and biologically relevant biomarkers able to reveal key pathogenic pathways and predict pregnancies at risk for antenatal fetal damage is a priority. Proteomics provides a unique opportunity to fill this gap. ..
  6. Trivedi S, Joachim M, McElrath T, Kliman H, Allred E, Fichorova R, et al. Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery. Am J Obstet Gynecol. 2012;206:236.e1-8 pubmed publisher
    ..Inflammation and infection, rather than premature activation of the fetal adrenal axis, should be the major focus of research to prevent extremely preterm human birth. ..
  7. Lee H, Kim E, Kim H, Choi C, Kim B, Choi J. Chorioamnionitis, respiratory distress syndrome and bronchopulmonary dysplasia in extremely low birth weight infants. J Perinatol. 2011;31:166-70 pubmed publisher
    To determine if histologic chorioamnionitis (HC) in the presence of respiratory distress syndrome (RDS) augments adverse pulmonary outcomes in extremely low birth weight (ELBW) infants...
  8. Tita A, Andrews W. Diagnosis and management of clinical chorioamnionitis. Clin Perinatol. 2010;37:339-54 pubmed publisher
    b>Chorioamnionitis is a common complication of pregnancy associated with significant maternal, perinatal, and long-term adverse outcomes...
  9. Romero R, Chaiworapongsa T, Alpay Savasan Z, Xu Y, Hussein Y, Dong Z, et al. Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1. J Matern Fetal Neonatal Med. 2011;24:1444-55 pubmed publisher
    ..HMGB1; and (2) localize immunoreactivity of HMGB1 in the fetal membranes and umbilical cord of patients with chorioamnionitis. Amniotic fluid samples were collected from the following groups: (1) preterm labor with intact membranes (..
  10. Romero R, Chaiworapongsa T, Savasan Z, Hussein Y, Dong Z, Kusanovic J, et al. Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE. J Matern Fetal Neonatal Med. 2012;25:558-67 pubmed publisher
    ..The objectives of this study were to determine whether: 1) clinical chorioamnionitis at term is associated with changes in amniotic fluid concentrations of HMGB1, sRAGE and esRAGE; and 2) the ..
  11. Moscuzza F, Belcari F, Nardini V, Bartoli A, Domenici C, Cuttano A, et al. Correlation between placental histopathology and fetal/neonatal outcome: chorioamnionitis and funisitis are associated to intraventricular haemorrage and retinopathy of prematurity in preterm newborns. Gynecol Endocrinol. 2011;27:319-23 pubmed publisher
    ..Placental anatomopathologic lesions are usually associated with pregnancy complications and neonatal impaired outcome...
  12. Westover A, Moss T. Effects of intrauterine infection or inflammation on fetal lung development. Clin Exp Pharmacol Physiol. 2012;39:824-30 pubmed publisher
    ..Elucidation of the effects of inflammation on the fetal lungs and other organs will allow more refined approaches to the care of preterm infants exposed to inflammation in utero...
  13. Andrys C, Drahosova M, Hornychova H, Tambor V, Musilova I, Tosner J, et al. Umbilical cord blood concentrations of IL-6, IL-8, and MMP-8 in pregnancy complicated by preterm premature rupture of the membranes and histological chorioamnionitis. Neuro Endocrinol Lett. 2010;31:857-63 pubmed
    ..of interleukin-6 (IL-6), interleukin-8 (IL-8), and matrix metalloproteinase-8 (MMP-8) are of value in the diagnosis of histological chorioamnionitis (HCA) and funisitis in patients with preterm premature rupture of membranes (PPROM).
  14. Luciano A, Yu H, Jackson L, Wolfe L, Bernstein H. Preterm labor and chorioamnionitis are associated with neonatal T cell activation. PLoS ONE. 2011;6:e16698 pubmed publisher
    ..This well established association leads us to hypothesize that preterm delivery is also associated with neonatal T lymphocyte activation and maturation...
  15. Lee S, Leung C. Histological chorioamnionitis - implication for bacterial colonization, laboratory markers of infection, and early onset sepsis in very-low-birth-weight neonates. J Matern Fetal Neonatal Med. 2012;25:364-8 pubmed publisher
    The objective of this study was to evaluate the relationship between histological chorioamnionitis and laboratory markers of infection and congenital sepsis in very-low-birth-weight (VLBW) premature neonates.
  16. Han Y, Fardini Y, Chen C, Iacampo K, Peraino V, Shamonki J, et al. Term stillbirth caused by oral Fusobacterium nucleatum. Obstet Gynecol. 2010;115:442-5 pubmed publisher
    ..Intrauterine infection is a recognized cause of adverse pregnancy outcome, but the source of infection is often undetermined. We report a case of stillbirth caused by Fusobacterium nucleatum that originated in the mother's mouth...
  17. Hecht J, Fichorova R, Tang V, Allred E, McElrath T, Leviton A. Relationship Between Neonatal Blood Protein Concentrations and Placenta Histologic Characteristics in Extremely Low GA Newborns. Pediatr Res. 2011;69:68-73 pubmed publisher
    Amniotic fluid infection with chorioamnionitis is associated with increased risks of morbidity and mortality in children born prematurely. These risks depend on the presence of a fetal inflammatory response...
  18. Strunk T, Doherty D, Jacques A, Simmer K, Richmond P, Kohan R, et al. Histologic chorioamnionitis is associated with reduced risk of late-onset sepsis in preterm infants. Pediatrics. 2012;129:e134-41 pubmed publisher
    Histologic chorioamnionitis (HCA) is implicated in the onset of preterm labor and delivery. Chorioamnionitis is a known risk factor for early-onset sepsis and may modulate postnatal immunity...
  19. Buchanan S, Crowther C, Levett K, Middleton P, Morris J. Planned early birth versus expectant management for women with preterm prelabour rupture of membranes prior to 37 weeks' gestation for improving pregnancy outcome. Cochrane Database Syst Rev. 2010;:CD004735 pubmed publisher
    ..Delivery after preterm prelabour rupture of the membranes (PPROM) may be initiated soon after PPROM or, alternatively, be delayed. It is unclear which strategy is most beneficial for mothers and their babies...
  20. Tsiartas P, Kacerovsky M, Musilova I, Hornychova H, Cobo T, Savman K, et al. The association between histological chorioamnionitis, funisitis and neonatal outcome in women with preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2013;26:1332-6 pubmed publisher
    To determine the impact of histological chorioamnionitis (HCA) and funisitis on neonatal outcome in preterm prelabor rupture of membranes (PPROM) pregnancies.
  21. Andersen C, Pillow J, Gill A, Allison B, Moss T, Hooper S, et al. The cerebral critical oxygen threshold of ventilated preterm lambs and the influence of antenatal inflammation. J Appl Physiol (1985). 2011;111:775-81 pubmed publisher
    ..Regardless of exposure to inflammation, there is a consistent postnatal relationship between cerebral oxygen delivery and consumption...
  22. Oh K, Park K, Kim S, Jeong E, Lee S, Yoon H. Predictive value of intra-amniotic and serum markers for inflammatory lesions of preterm placenta. Placenta. 2011;32:732-6 pubmed publisher
    ..AF) matrix metalloproteinase-9 (MMP-9), interleukin-6 (IL-6), and serum C-reactive protein (CRP) for histologic chorioamnionitis and intra-amniotic infection in women with preterm labor or preterm premature rupture of membranes (PROM).
  23. Lee J, Romero R, Dong Z, Xu Y, Qureshi F, Jacques S, et al. Unexplained fetal death has a biological signature of maternal anti-fetal rejection: chronic chorioamnionitis and alloimmune anti-human leucocyte antigen antibodies. Histopathology. 2011;59:928-38 pubmed publisher
    Chronic chorioamnionitis is a histological manifestation of maternal anti-fetal cellular rejection...
  24. Dessardo N, Mustac E, Dessardo S, Banac S, Peter B, Finderle A, et al. Chorioamnionitis and chronic lung disease of prematurity: a path analysis of causality. Am J Perinatol. 2012;29:133-40 pubmed publisher
    ..was to test a new statistical framework incorporating path analysis to evaluate causality between exposure to chorioamnionitis and fetal inflammatory response syndrome and the development of chronic lung disease of prematurity...
  25. Soraisham A, Trevenen C, Wood S, Singhal N, Sauve R. Histological chorioamnionitis and neurodevelopmental outcome in preterm infants. J Perinatol. 2013;33:70-5 pubmed publisher
    The objective of this study is to examine the neurodevelopmental outcome at 30 to 42 months corrected age of preterm infants with histological chorioamnionitis (HCA).
  26. Jobe A. Effects of chorioamnionitis on the fetal lung. Clin Perinatol. 2012;39:441-57 pubmed publisher
    Very preterm infants are commonly exposed to a chronic, often asymptomatic, chorioamnionitis that is diagnosed by histologic evaluation of the placenta only after delivery...
  27. Galinsky R, Moss T, Gubhaju L, Hooper S, Black M, Polglase G. Effect of intra-amniotic lipopolysaccharide on nephron number in preterm fetal sheep. Am J Physiol Renal Physiol. 2011;301:F280-5 pubmed publisher
    b>Chorioamnionitis is an antecedent of preterm birth. We aimed to determine the effect of experimental chorioamnionitis in fetal sheep during late gestation on 1) nephron number, 2) renal corpuscle volume, and 3) renal inflammation...
  28. Sato M, Nishimaki S, Yokota S, Seki K, Horiguchi H, An H, et al. Severity of chorioamnionitis and neonatal outcome. J Obstet Gynaecol Res. 2011;37:1313-9 pubmed publisher
    The aim of this study is to elucidate whether the stage of chorioamnionitis is or is not associated with the development of neonatal diseases.
  29. Schlapbach L, Ersch J, Adams M, Bernet V, Bucher H, Latal B. Impact of chorioamnionitis and preeclampsia on neurodevelopmental outcome in preterm infants below 32 weeks gestational age. Acta Paediatr. 2010;99:1504-9 pubmed publisher
    Intrauterine conditions may interfere with foetal brain development. We compared the neurodevelopmental outcome between infants <32 weeks gestational age after maternal preeclampsia or chorioamnionitis and controls.
  30. Ben Amara A, Gorvel L, Baulan K, Derain Court J, Buffat C, Verollet C, et al. Placental macrophages are impaired in chorioamnionitis, an infectious pathology of the placenta. J Immunol. 2013;191:5501-14 pubmed publisher
    ..immune tolerance affected the functions of resident macrophages and if their functions were altered during chorioamnionitis, an infectious pathology of the placenta...
  31. Berry C, Nitsos I, Hillman N, Pillow J, Polglase G, Kramer B, et al. Interleukin-1 in lipopolysaccharide induced chorioamnionitis in the fetal sheep. Reprod Sci. 2011;18:1092-102 pubmed publisher
    We tested the hypothesis that interleukin 1 (IL-1) mediates intra-amniotic lipopolysaccharide (LPS)-induced chorioamnionitis in preterm fetal sheep...
  32. Lee J, Romero R, Xu Y, Kim J, Topping V, Yoo W, et al. A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d. PLoS ONE. 2011;6:e16806 pubmed publisher
    Chronic chorioamnionitis is found in more than one-third of spontaneous preterm births. Chronic chorioamnionitis and villitis of unknown etiology represent maternal anti-fetal cellular rejection...
  33. Hartling L, Liang Y, Lacaze Masmonteil T. Chorioamnionitis as a risk factor for bronchopulmonary dysplasia: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2012;97:F8-F17 pubmed publisher
    To conduct a systematic review of the association between chorioamnionitis (CA) and bronchopulmonary dysplasia (BPD) in preterm infants.
  34. Thomas W, Speer C. Chorioamnionitis: important risk factor or innocent bystander for neonatal outcome?. Neonatology. 2011;99:177-87 pubmed publisher
    b>Chorioamnionitis as a major risk factor for spontaneous preterm birth, especially at earlier gestational ages, contributes to prematurity-associated mortality and morbidity...
  35. Gantert M, Been J, Gavilanes A, Garnier Y, Zimmermann L, Kramer B. Chorioamnionitis: a multiorgan disease of the fetus?. J Perinatol. 2010;30 Suppl:S21-30 pubmed publisher
    The bacterial infection of chorion and amnion is a common finding in premature delivery and is referred to as chorioamnionitis. As the mother rarely shows symptoms of a systemic inflammation, the course of chorioamnionitis is frequently ..
  36. Wolfs T, Jellema R, Turrisi G, Becucci E, Buonocore G, Kramer B. Inflammation-induced immune suppression of the fetus: a potential link between chorioamnionitis and postnatal early onset sepsis. J Matern Fetal Neonatal Med. 2012;25 Suppl 1:8-11 pubmed publisher
    b>Chorioamnionitis which results from microbial invasion of the amniotic cavity is the most frequent cause of preterm birth...
  37. Shatrov J, Birch S, Lam L, Quinlivan J, McIntyre S, Mendz G. Chorioamnionitis and cerebral palsy: a meta-analysis. Obstet Gynecol. 2010;116:387-92 pubmed publisher
    To examine the relationships between clinical or histological chorioamnionitis and cerebral palsy using a meta-analysis approach.
  38. Homer L, Launay E, Joram N, Jacqueline C, Jarreau P, Caillon J, et al. Antenatal phosphodiesterase 4 inhibition restores postnatal growth and pulmonary development in a model of chorioamnionitis in rabbits. J Pharmacol Exp Ther. 2012;340:620-8 pubmed publisher
    b>Chorioamnionitis is implicated in the pathophysiology of bronchopulmonary disease, and the associated inflammatory response is responsible for adverse effects on alveolar development...
  39. Belli S, Yalçinkaya C, Ezer A, Bolat F, Colakoglu T, Simsek E. Stump appendicitis and chorioamnionitis due to incomplete appendectomy: a case report. Turk J Gastroenterol. 2011;22:540-3 pubmed
    ..A rare case occurred of stump appendicitis and chorioamnionitis complicating after incomplete appendectomy...
  40. Xu Y, Tarquini F, Romero R, Kim C, Tarca A, Bhatti G, et al. Peripheral CD300a+CD8+ T lymphocytes with a distinct cytotoxic molecular signature increase in pregnant women with chronic chorioamnionitis. Am J Reprod Immunol. 2012;67:184-97 pubmed publisher
    ..This study was conducted to assess the biological significance of CD300a expression in T lymphocytes and to determine whether its expression in peripheral T lymphocytes changes in pregnant women presenting with antifetal rejection...
  41. Wang B, Navath R, Menjoge A, Balakrishnan B, Bellair R, Dai H, et al. Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers. Int J Pharm. 2010;395:298-308 pubmed publisher
    ..showed potential to treat the Escherichia coli induced ascending uterine infection in guinea pig model of chorioamnionitis. Amniotic fluid collected from different gestational sacs of infected guinea pigs posttreatment showed ..
  42. Digiulio D, Romero R, Kusanovic J, Gomez R, Kim C, Seok K, et al. Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes. Am J Reprod Immunol. 2010;64:38-57 pubmed publisher
    ..The role played by microbial invasion of the amniotic cavity (MIAC) in preterm pre-labor rupture of membranes (pPROM) is inadequately characterized, in part because of reliance on cultivation-based methods...
  43. Jung H, Park K, Kim S, Hong J, Oh K, Kim G, et al. Non-invasive prediction of intra-amniotic inflammation in women with preterm labor. Ultrasound Obstet Gynecol. 2011;37:82-7 pubmed publisher
    ..To develop a model based on non-invasive variables to predict the probability of intra-amniotic inflammation in women with preterm labor and intact membranes...
  44. Kuypers E, Collins J, Jellema R, Wolfs T, Kemp M, Nitsos I, et al. Ovine fetal thymus response to lipopolysaccharide-induced chorioamnionitis and antenatal corticosteroids. PLoS ONE. 2012;7:e38257 pubmed publisher
    b>Chorioamnionitis is associated with preterm delivery and involution of the fetal thymus. Women at risk of preterm delivery receive antenatal corticosteroids which accelerate fetal lung maturation and improve neonatal outcome...
  45. Digiulio D, Gervasi M, Romero R, Vaisbuch E, Mazaki Tovi S, Kusanovic J, et al. Microbial invasion of the amniotic cavity in pregnancies with small-for-gestational-age fetuses. J Perinat Med. 2010;38:495-502 pubmed publisher
    ..The aim of this study was to determine the frequency, diversity and relative abundance of microbes in amniotic fluid (AF) of women with an SGA neonate using a combination of culture and molecular methods...
  46. Polglase G, Dalton R, Nitsos I, Knox C, Pillow J, Jobe A, et al. Pulmonary vascular and alveolar development in preterm lambs chronically colonized with Ureaplasma parvum. Am J Physiol Lung Cell Mol Physiol. 2010;299:L232-41 pubmed publisher
    Ureaplasma species, the most commonly isolated microorganisms in women with chorioamnionitis, are associated with preterm delivery...
  47. Aghai Z, Camacho J, Saslow J, Mody K, Eydelman R, Bhat V, et al. Impact of histological chorioamnionitis on tracheal aspirate cytokines in premature infants. Am J Perinatol. 2012;29:567-72 pubmed publisher
    Histological chorioamnionitis (CHORIO) may increase inflammatory mediators in the lungs of preterm infants.
  48. Polglase G, Hooper S, Gill A, Allison B, Crossley K, Moss T, et al. Intrauterine inflammation causes pulmonary hypertension and cardiovascular sequelae in preterm lambs. J Appl Physiol (1985). 2010;108:1757-65 pubmed publisher
    b>Chorioamnionitis increases the risk and severity of persistent pulmonary hypertension of the newborn in preterm infants...
  49. Been J, Lievense S, Zimmermann L, Kramer B, Wolfs T. Chorioamnionitis as a risk factor for necrotizing enterocolitis: a systematic review and meta-analysis. J Pediatr. 2013;162:236-42.e2 pubmed publisher
    ..To accumulate available evidence regarding the association between antenatal inflammation and necrotizing enterocolitis (NEC)...
  50. Mi Lee S, Romero R, Lee K, Jin Yang H, Joon Oh K, Park C, et al. The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor. J Matern Fetal Neonatal Med. 2011;24:37-42 pubmed publisher
    To examine the frequency and risk factors of funisitis and histologic chorioamnionitis in the placentas of term pregnant women who delivered after the spontaneous onset of labor.
  51. Hatfield T, Wing D, Buss C, Head K, Muftuler L, Davis E. Magnetic resonance imaging demonstrates long-term changes in brain structure in children born preterm and exposed to chorioamnionitis. Am J Obstet Gynecol. 2011;205:384.e1-8 pubmed publisher
    We sought to determine if children born preterm and exposed to chorioamnionitis have differences in brain structure measured at 6-10 years of age using magnetic resonance imaging (MRI).
  52. Abdulkadir A, Kimimasa T, Bell M, Macpherson T, Keller B, Yanowitz T. Placental inflammation and fetal hemodynamics in a rat model of chorioamnionitis. Pediatr Res. 2010;68:513-8 pubmed publisher
    ..fetal cardiovascular function and cerebral blood flow velocity (BFV) would be decreased in a rat model of chorioamnionitis. We also tested whether placental inflammation was related to proximity to the cervix in our model of ..
  53. Lopez E, Raymond J, Patkai J, El Ayoubi M, Schmitz T, Moriette G, et al. Capnocytophaga species and preterm birth: case series and review of the literature. Clin Microbiol Infect. 2010;16:1539-43 pubmed publisher
    ..a genus of Gram-negative anaerobes that inhabit the oral cavity, has been reported to be an unusual cause of chorioamnionitis and neonatal infection. We report five cases of Capnocytophaga spp...
  54. Buhimschi I, Buhimschi C. Proteomics/diagnosis of chorioamnionitis and of relationships with the fetal exposome. Semin Fetal Neonatal Med. 2012;17:36-45 pubmed publisher
    ..From a proteomics perspective, chorioamnionitis poses both challenges and opportunities...
  55. Shah T, Hillman N, Nitsos I, Polglase G, Pillow J, Newnham J, et al. Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis. Pediatr Res. 2010;68:210-5 pubmed publisher
    ..MCP-1 and MCP-2) mediate monocyte and T-lymphocyte chemotaxis, and IL-1 contributes to the pathogenesis of chorioamnionitis-induced lung inflammation and fetal inflammatory responses...
  56. Bersani I, Thomas W, Speer C. Chorioamnionitis--the good or the evil for neonatal outcome?. J Matern Fetal Neonatal Med. 2012;25 Suppl 1:12-6 pubmed publisher
    b>Chorioamnionitis represents a major risk factor for preterm birth and contributes to prematurity-associated morbidity and mortality...
  57. Thomas W, Seidenspinner S, Kawczyńska Leda N, Wirbelauer J, Szymankiewicz M, Speer C. Soluble receptor for advanced glycation end products (sRAGE) in tracheobronchial aspirate fluid and cord blood of very low birth weight infants with chorioamnionitis and funisitis. Early Hum Dev. 2010;86:593-8 pubmed publisher
    ..Soluble RAGE (sRAGE) is created by alternative mRNA splicing or shedding of the receptor's extracellular domain and can inhibit RAGE-activation...
  58. Lee J, Romero R, Xu Y, Kim J, Park J, Kusanovic J, et al. Maternal HLA panel-reactive antibodies in early gestation positively correlate with chronic chorioamnionitis: evidence in support of the chronic nature of maternal anti-fetal rejection. Am J Reprod Immunol. 2011;66:510-26 pubmed publisher
    ..Chronic chorioamnionitis is a feature of anti-fetal cellular rejection...
  59. Hendson L, Russell L, Robertson C, Liang Y, Chen Y, Abdalla A, et al. Neonatal and neurodevelopmental outcomes of very low birth weight infants with histologic chorioamnionitis. J Pediatr. 2011;158:397-402 pubmed publisher
    To determine survival and neurodevelopmental outcomes at 18 months corrected age among very low birth weight infants ? 32 weeks gestation with histologic chorioamnionitis.
  60. Musilova I, Kacerovsky M, Hornychova H, Kostal M, Jacobsson B. Pulsation of the fetal splenic vein--a potential ultrasound marker of histological chorioamnionitis and funisitis in women with preterm prelabor rupture of membranes. Acta Obstet Gynecol Scand. 2012;91:1119-23 pubmed publisher
    ..The aim of the study was to determine whether the presence of histological chorioamnionitis and funisitis is associated with a continuous or pulsatile flow pattern in the fetal splenic vein...
  61. Ogge G, Romero R, Lee D, Gotsch F, Than N, Lee J, et al. Chronic chorioamnionitis displays distinct alterations of the amniotic fluid proteome. J Pathol. 2011;223:553-65 pubmed publisher
    Acute chorioamnionitis of infectious origin and chronic chorioamnionitis of immunological origin are two major placental lesions of spontaneous preterm birth with elevated amniotic fluid interleukin-6 and CXCL10 concentrations, ..
  62. Kunzmann S, Glogger K, Been J, Kallapur S, Nitsos I, Moss T, et al. Thymic changes after chorioamnionitis induced by intraamniotic lipopolysaccharide in fetal sheep. Am J Obstet Gynecol. 2010;202:476.e1-9 pubmed publisher
    ..We asked whether fetal inflammation caused by chorioamnionitis would modulate thymus development.
  63. Oh K, Lee K, Sohn Y, Park C, Hong J, Romero R, et al. Intraamniotic infection with genital mycoplasmas exhibits a more intense inflammatory response than intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes. Am J Obstet Gynecol. 2010;203:211.e1-8 pubmed publisher
    ..The objective of the study was to compare the intensity of inflammatory responses between intraamniotic infection with genital mycoplasmas and intraamniotic infection with other microorganisms...
  64. Collins J, Kuypers E, Nitsos I, Jane Pillow J, Polglase G, Kemp M, et al. LPS-induced chorioamnionitis and antenatal corticosteroids modulate Shh signaling in the ovine fetal lung. Am J Physiol Lung Cell Mol Physiol. 2012;303:L778-87 pubmed publisher
    b>Chorioamnionitis and antenatal corticosteroids mature the fetal lung functionally but disrupt late-gestation lung development...
  65. Galinsky R, Polglase G, Hooper S, Black M, Moss T. The consequences of chorioamnionitis: preterm birth and effects on development. J Pregnancy. 2013;2013:412831 pubmed publisher
    Preterm birth is a major cause of perinatal mortality and long-term morbidity. Chorioamnionitis is a common cause of preterm birth...
  66. Cobo T, Kacerovsky M, Palacio M, Hornychova H, Hougaard D, Skogstrand K, et al. A prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes: analyses of multiple proteins in the amniotic fluid. J Matern Fetal Neonatal Med. 2012;25:1995-2001 pubmed publisher
    To determine the best prediction model of histological chorioamnionitis and funisitis in preterm prelabor rupture of membranes (PPROM) using selected candidate proteins in the amniotic fluid (AF).
  67. Schlapbach L, Frey S, Bigler S, Manh Nhi C, Aebi C, Nelle M, et al. Copeptin concentration in cord blood in infants with early-onset sepsis, chorioamnionitis and perinatal asphyxia. BMC Pediatr. 2011;11:38 pubmed publisher
    ..In contrast, its involvement in neonatal diseases remains unknown. The aim of this study was to establish copeptin concentrations in neonates of different stress states such as sepsis, chorioamnionitis and asphyxia.
  68. Joerink M, Rindsjö E, van Riel B, Alm J, Papadogiannakis N. Placental macrophage (Hofbauer cell) polarization is independent of maternal allergen-sensitization and presence of chorioamnionitis. Placenta. 2011;32:380-5 pubmed publisher
    ..Hofbauer cells) is influenced by the allergen-sensitization status of the mother and/or the presence of chorioamnionitis, a placental inflammation...
  69. Wolfs T, Kramer B, Thuijls G, Kemp M, Saito M, Willems M, et al. Chorioamnionitis-induced fetal gut injury is mediated by direct gut exposure of inflammatory mediators or by lung inflammation. Am J Physiol Gastrointest Liver Physiol. 2014;306:G382-93 pubmed publisher
    Intra-amniotic exposure to proinflammatory agonists causes chorioamnionitis and fetal gut inflammation. Fetal gut inflammation is associated with mucosal injury and impaired gut development...
  70. Botet F, Figueras J, Carbonell Estrany X, Arca G, The Castrillo Study Group -. Effect of maternal clinical chorioamnionitis on neonatal morbidity in very-low birthweight infants: a case-control study. J Perinat Med. 2010;38:269-73 pubmed publisher
    To assess the relationship between maternal clinical chorioamnionitis and neonatal outcome in preterm very-low birthweight (VLBW) infants.
  71. Martinelli P, Sarno L, Maruotti G, Paludetto R. Chorioamnionitis and prematurity: a critical review. J Matern Fetal Neonatal Med. 2012;25 Suppl 4:29-31 pubmed publisher
    b>Chorioamnionitis is the inflammatory response to an acute inflammation of the membranes and chorion of the placenta...
  72. Rovira N, Alarcon A, Iriondo M, Ibañez M, Poo P, Cusi V, et al. Impact of histological chorioamnionitis, funisitis and clinical chorioamnionitis on neurodevelopmental outcome of preterm infants. Early Hum Dev. 2011;87:253-7 pubmed publisher
    The role of chorioamnionitis in neurodevelopment of preterm infants is not fully understood.