urinary bladder neck obstruction


Summary: Blocked urine flow through the bladder neck, the narrow internal urethral opening at the base of the URINARY BLADDER. Narrowing or strictures of the URETHRA can be congenital or acquired. It is often observed in males with enlarged PROSTATE glands.

Top Publications

  1. Mohamad Al Ali B, Ponholzer A, Augustin H, Madersbacher S, Pummer K. The Long-Term Effect of Radical Prostatectomy on Erectile Function, Urinary Continence, and Lower Urinary Tract Symptoms: A Comparison to Age-Matched Healthy Controls. Biomed Res Int. 2017;2017:9615080 pubmed publisher
    ..Healthy men have a higher IPSS presumably due to the presence of bladder outlet obstruction. ..
  2. Griffiths D, Hofner K, van Mastrigt R, Rollema H, Spangberg A, Gleason D. Standardization of terminology of lower urinary tract function: pressure-flow studies of voiding, urethral resistance, and urethral obstruction. International Continence Society Subcommittee on Standardization of Terminology of Pressure-Flow Studies. Neurourol Urodyn. 1997;16:1-18 pubmed
  3. Griebling T. Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence, and bladder outlet obstruction. BJU Int. 2011;108:1138-9 pubmed publisher
  4. Coplen D, Barthold J. Controversies in the management of ectopic ureteroceles. Urology. 2000;56:665-8 pubmed
  5. Hughes F, Sexton S, Jin H, Govada V, Purves J. Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1?. Am J Physiol Renal Physiol. 2017;313:F603-F610 pubmed publisher
    ..In summary, NLRP3-derived-IL-1? triggers fibrosis during BOO, most likely through an autocrine loop in which IL-1? acts on urothelia to drive collagen production. ..
  6. Gosling J, Gilpin S, Dixon J, Gilpin C. Decrease in the autonomic innervation of human detrusor muscle in outflow obstruction. J Urol. 1986;136:501-4 pubmed
    ..This finding provides additional evidence that functional impairment of the urinary bladder occurs in response to outflow obstruction and emphasizes the need for prompt relief of the condition. ..
  7. Lee H, Lee Y, Han D, Lee K. Change of Ultrasound Estimated Bladder Weight and Bladder Wall Thickness After Treatment of Bladder Outlet Obstruction With Dutasteride. Low Urin Tract Symptoms. 2017;9:67-74 pubmed publisher
    ..There was no change in UEBW, UEBW/BSA and BWT despite improving most clinical parameters suggesting BOO. The changes of bladder wall hypertrophy parameters still have limitations to directly reflect the relief of BOO. ..
  8. Firat F, Uluocak N, Erdemir F, Atilgan D, Markoc F, Parlaktas B, et al. Evaluation of the effects of omega-3 & interferon alpha-2b administration on partial bladder outlet obstruction in a rat model. Indian J Med Res. 2016;144:572-579 pubmed publisher
    ..However, this needs to be further investigated with prospective, randomized clinical trials with larger sample sizes. ..
  9. Pannek J. Editorial comment on: classification of male lower urinary tract symptoms using mathematical modelling and a regression tree algorithm of noninvasive near-infrared spectroscopy parameters. Eur Urol. 2010;57:332-3 pubmed publisher

More Information


  1. van Mastrigt R, Pel J. Towards a noninvasive urodynamic diagnosis of infravesical obstruction. BJU Int. 1999;84:195-203 pubmed
  2. Hinman F, Baumann F. Complications of vesicoureteral operations from incoordination of micturition. J Urol. 1976;116:638-43 pubmed
  3. Rademakers K, Drake M, Gammie A, Djurhuus J, Rosier P, Abrams P, et al. Male bladder outlet obstruction: Time to re-evaluate the definition and reconsider our diagnostic pathway? ICI-RS 2015. Neurourol Urodyn. 2017;36:894-901 pubmed publisher
    ..Therefore, the think tank suggests further research with regard to these alternative indicators to determine their clinical utility. ..
  4. Netto Júnior N, D Ancona C, de Lima M. Correlation between the International Prostatic Symptom Score and a pressure-flow study in the evaluation of symptomatic benign prostatic hyperplasia. J Urol. 1996;155:200-2 pubmed
    ..91. When the total I-PSS is greater than 28 or the obstructive symptom score is greater than 15, a pressure-flow study must be avoided. ..
  5. Abrams P, Griffiths D. The assessment of prostatic obstruction from urodynamic measurements and from residual urine. Br J Urol. 1979;51:129-34 pubmed
    ..Residual urine is a sign of an abnormality of bladder function rather than the direct result of urethral obstruction. ..
  6. Gosling J. Modification of bladder structure in response to outflow obstruction and ageing. Eur Urol. 1997;32 Suppl 1:9-14 pubmed
    ..As the morphology of the obstructed bladder differs from that of the ageing bladder, it is unlikely that the changes seen in the obstructed bladder simply reflect a function of age. ..
  7. Holm N, Horn T, Hald T. Detrusor in ageing and obstruction. Scand J Urol Nephrol. 1995;29:45-9 pubmed
    ..Our results give rise to the question whether "prostatism" is related to obstruction per se or to ageing or both. ..
  8. Sugiyama R, Aizawa N, Ito H, Fujimura T, Suzuki M, Nakagawa T, et al. Synergic Suppressive Effect of Silodosin and Imidafenacin on Non-Voiding Bladder Contractions in Male Rats with Subacute Bladder Outlet Obstruction. Low Urin Tract Symptoms. 2017;9:94-101 pubmed publisher
    ..The present results indicate a suppressive effect of silodosin or imidafenacin alone and a synergic effect of the combination of these two drugs on NVCs in a subacute BOO model of male rats. ..
  9. Walter J, Andros G, Stokes S, Wheeler J, Damaser M, Sacks J, et al. Urodynamic verification of noninvasive back-pressure recordings from the urinary bladder. Tech Urol. 1998;4:185-91 pubmed
    ..Thus, the modifications have improved back-pressure recording techniques. The use of noninvasive back-pressure recording may be an important adjunct in the evaluation of obstructive uropathy. ..
  10. Schafer W. Analysis of bladder-outlet function with the linearized passive urethral resistance relation, linPURR, and a disease-specific approach for grading obstruction: from complex to simple. World J Urol. 1995;13:47-58 pubmed
  11. Majima T, Yamamoto T, Funahashi Y, Takai S, Matsukawa Y, Yoshida M, et al. Effect of Naftopidil on Bladder Microcirculation in a Rat Model of Bladder Outlet Obstruction. Low Urin Tract Symptoms. 2017;9:111-116 pubmed publisher
    ..Naftopidil improved bladder overactivity as well as the impaired bladder blood flow.caused by bladder-outlet-obstruction. ..
  12. Soto Palou F, Sánchez Ortiz R. Outcomes of Minimally Invasive Inguinal Hernia Repair at the Time of Robotic Radical Prostatectomy. Curr Urol Rep. 2017;18:43 pubmed publisher
  13. Krivoborodov G, Efremov N, Bolotov A. [Intravesical prostatic protrusion in diagnosing infravesical obstruction in men with benign prostatic hyperplasia]. Urologiia. 2017;:105-109 pubmed
    ..The initial findings on the relationship between IPP and IVO suggest the feasibility of its clinical use as a screening tool in men with obstructive voiding symptoms. ..
  14. Lucarotti M, Feneley R, Abrams P. A urine flow clinic. Bristol Med Chir J. 1988;103:17-9 pubmed