interstitial cystitis

Summary

Summary: A condition with recurring discomfort or pain in the URINARY BLADDER and the surrounding pelvic region without an identifiable disease. Severity of pain in interstitial cystitis varies greatly and often is accompanied by increased urination frequency and urgency.

Top Publications

  1. Rosamilia A. Painful bladder syndrome/interstitial cystitis. Best Pract Res Clin Obstet Gynaecol. 2005;19:843-59 pubmed
    ..b>Interstitial cystitis (IC) is the established term used by the National Institute of Diabetes and Digestive and Kidney Diseases (..
  2. Zhang C, Wang J, Koch K, Keay S. Regulation of tight junction proteins and bladder epithelial paracellular permeability by an antiproliferative factor from patients with interstitial cystitis. J Urol. 2005;174:2382-7 pubmed
    Previous reports have suggested that the bladder epithelial barrier may be compromised in interstitial cystitis (IC)...
  3. Nickel J, Tripp D, Pontari M, Moldwin R, Mayer R, Carr L, et al. Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome. J Urol. 2010;184:1358-63 pubmed publisher
    We characterized and compared the impact of clinical phenotypic associations between interstitial cystitis/painful bladder syndrome and controls in relation to potentially related conditions, particularly irritable bowel syndrome, ..
  4. Gardella B, Porru D, Ferdeghini F, Martinotti Gabellotti E, Nappi R, Rovereto B, et al. Insight into urogynecologic features of women with interstitial cystitis/painful bladder syndrome. Eur Urol. 2008;54:1145-51 pubmed publisher
    The prevalence of interstitial cystitis/painful bladder syndrome (IC/PBS) among gynecologic patients attending vulvar disease or pelvic pain clinics is higher than expected...
  5. Chung M, Chung R, Gordon D. Interstitial cystitis and endometriosis in patients with chronic pelvic pain: The "Evil Twins" syndrome. JSLS. 2005;9:25-9 pubmed
    To determine the prevalence of interstitial cystitis and endometriosis in patients with chronic pelvic pain...
  6. Boucher W, Stern J, Kotsinyan V, Kempuraj D, Papaliodis D, Cohen M, et al. Intravesical nanocrystalline silver decreases experimental bladder inflammation. J Urol. 2008;179:1598-602 pubmed publisher
    b>Interstitial cystitis is a sterile bladder inflammatory disease characterized by pelvic pain, urinary urgency and frequency...
  7. Ottem D, Teichman J. What is the value of cystoscopy with hydrodistension for interstitial cystitis?. Urology. 2005;66:494-9 pubmed
    To determine the utility of cystoscopy with hydrodistension for the diagnosis and therapy of interstitial cystitis. Cystoscopy with hydrodistension is the most commonly performed diagnostic test and procedure in patients with ..
  8. Nickel J, Teichman J, Gregoire M, Clark J, Downey J. Prevalence, diagnosis, characterization, and treatment of prostatitis, interstitial cystitis, and epididymitis in outpatient urological practice: the Canadian PIE Study. Urology. 2005;66:935-40 pubmed
    To determine the prevalence, diagnostic patterns, and management of prostatitis, interstitial cystitis, and epididymitis (PIE) in Canadian urology outpatient practice.
  9. Pezzone M, Liang R, Fraser M. A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders. Gastroenterology. 2005;128:1953-64 pubmed
    Irritable bowel syndrome, interstitial cystitis, and other chronic pelvic pain (CPP) disorders often occur concomitantly. Neural cross-talk may play a role in the overlap of CPP disorders via the convergence of pelvic afferents...

More Information

Publications81

  1. Paulson J, Delgado M. Chronic pelvic pain: the occurrence of interstitial cystitis in a gynecological population. JSLS. 2005;9:426-30 pubmed
    The objective of this study was to determine what relationship exists between interstitial cystitis and chronic pelvic pain in patients...
  2. Chai T, Keay S. New theories in interstitial cystitis. Nat Clin Pract Urol. 2004;1:85-9 pubmed
    b>Interstitial cystitis (IC) is a chronic symptom-complex characterized by pathological sensation of the bladder (i.e...
  3. Oyama I, Rejba A, Lukban J, Fletcher E, Kellogg Spadt S, Holzberg A, et al. Modified Thiele massage as therapeutic intervention for female patients with interstitial cystitis and high-tone pelvic floor dysfunction. Urology. 2004;64:862-5 pubmed
    ..manual therapy of the pelvic floor musculature (Thiele massage) in symptomatic female patients with interstitial cystitis and high-tone dysfunction of the pelvic floor...
  4. Kelada E, Jones A. Interstitial cystitis. Arch Gynecol Obstet. 2007;275:223-9 pubmed
    b>Interstitial cystitis is an enigmatic and frustrating condition to manage as a physician and to cope with as a patient. Traditionally, it has been defined as a chronic sterile inflammatory disease of the bladder of unknown aetiology...
  5. Parsons C. The role of the urinary epithelium in the pathogenesis of interstitial cystitis/prostatitis/urethritis. Urology. 2007;69:9-16 pubmed
    ..In interstitial cystitis (IC), disruption of the urothelial barrier may initiate a cascade of events in the bladder, leading to ..
  6. Sung V, Hampton B. Epidemiology of pelvic floor dysfunction. Obstet Gynecol Clin North Am. 2009;36:421-43 pubmed publisher
    ..pelvic floor disorders, including urinary incontinence, pelvic organ prolapse, anal incontinence, and interstitial cystitis/painful bladder syndrome is reviewed...
  7. Zeng Y, Wu X, Homma Y, Yoshimura N, Iwaki H, Kageyama S, et al. Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis. J Urol. 2007;178:1322-7; discussion 1327 pubmed
    b>Interstitial cystitis remains a poorly understood urological condition characterized by chronic pelvic pain and increased urinary frequency in the absence of any known etiology...
  8. Kuromitsu S, Yokota H, Hiramoto M, Morita S, Mita H, Yamada T. Increased concentration of neutrophil elastase in urine from patients with interstitial cystitis. Scand J Urol Nephrol. 2008;42:455-61 pubmed publisher
    To identify proteins associated with interstitial cystitis (IC), protein profiles were analyzed using a proteomics-based approach. The study tested whether neutrophil elastase in urine correlates with the symptomatic condition of IC...
  9. Erickson D, Tomaszewski J, Kunselman A, Bentley C, Peters K, Rovner E, et al. Do the National Institute of Diabetes and Digestive and Kidney Diseases cystoscopic criteria associate with other clinical and objective features of interstitial cystitis?. J Urol. 2005;173:93-7 pubmed
    We compared urine markers, bladder biopsy findings and clinical features of patients with symptoms of interstitial cystitis (IC) who did or did not meet the cystoscopic criteria defined by the National Institute of Diabetes and Digestive ..
  10. van de Merwe J, Nordling J, Bouchelouche P, Bouchelouche K, Cervigni M, Daha L, et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol. 2008;53:60-7 pubmed
    Because the term "interstitial cystitis" (IC) has different meanings in different centers and different parts of the world, the European Society for the Study of Interstitial Cystitis (ESSIC) has worked to create a consensus on ..
  11. van Ophoven A, Hertle L. Long-term results of amitriptyline treatment for interstitial cystitis. J Urol. 2005;174:1837-40 pubmed
    ..efficacy of the long-term administration of the tricyclic antidepressant amitriptyline in patients with interstitial cystitis (IC)...
  12. Sant G, Kempuraj D, Marchand J, Theoharides T. The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis. Urology. 2007;69:34-40 pubmed
    ..laboratory studies confirms that mast cells play a central role in the pathogenesis and pathophysiology of interstitial cystitis (IC)...
  13. Nickel J, Parsons C, Forrest J, Kaufman D, Evans R, Chen A, et al. Improvement in sexual functioning in patients with interstitial cystitis/painful bladder syndrome. J Sex Med. 2008;5:394-9 pubmed
    Sexual functioning is one of the strongest predictors of poorer quality of life (QOL) in patients diagnosed with interstitial cystitis/painful bladder syndrome (IC/PBS).
  14. Riedl C, Engelhardt P, Daha K, Morakis N, Pfluger H. Hyaluronan treatment of interstitial cystitis/painful bladder syndrome. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19:717-21 pubmed
    The aim of this study is to evaluate the efficacy of intravesical hyaluronan therapy in interstitial cystitis/painful bladder syndrome (IC/PBS). One hundred twenty-six patients with IC/PBS and an average disease duration of 6...
  15. van de Merwe J. Interstitial cystitis and systemic autoimmune diseases. Nat Clin Pract Urol. 2007;4:484-91 pubmed
    The cause of interstitial cystitis, a chronic disease that affects the bladder, is unknown...
  16. Graham E, Chai T. Dysfunction of bladder urothelium and bladder urothelial cells in interstitial cystitis. Curr Urol Rep. 2006;7:440-6 pubmed
    ..Current evidence in interstitial cystitis (IC) supports multiple abnormalities in bladder urothelial physiology...
  17. Peng C, Kuo H. Multiple intravesical instillations of low-dose resiniferatoxin in the treatment of refractory interstitial cystitis. Urol Int. 2007;78:78-81 pubmed
    Current medications used in the treatment of interstitial cystitis (IC) have limited efficacy. This prospective study investigated the efficacy of multiple intravesical instillations of resiniferatoxin (RTX) at the concentration of 10 nM.
  18. Bogart L, Berry S, Clemens J. Symptoms of interstitial cystitis, painful bladder syndrome and similar diseases in women: a systematic review. J Urol. 2007;177:450-6 pubmed
    In women symptoms of interstitial cystitis are difficult to distinguish from those of painful bladder syndrome and they appear to overlap with those of urinary tract infection, chronic urethral syndrome, overactive bladder, vulvodynia ..
  19. Weinstock L, Klutke C, Lin H. Small intestinal bacterial overgrowth in patients with interstitial cystitis and gastrointestinal symptoms. Dig Dis Sci. 2008;53:1246-51 pubmed
    b>Interstitial cystitis (IC) often coexists with irritable bowel syndrome (IBS). IBS may be explained by small-intestinal bacterial overgrowth (SIBO), which increases immune activation and visceral hypersensitivity...
  20. Hauser P, Dozmorov M, Bane B, Slobodov G, Culkin D, Hurst R. Abnormal expression of differentiation related proteins and proteoglycan core proteins in the urothelium of patients with interstitial cystitis. J Urol. 2008;179:764-9 pubmed
    ..differentiation related markers of keratins 18 and 20 were examined to determine the origins of the loss of the glycosaminoglycan layer and investigate more fully the altered differentiation of the urothelium in interstitial cystitis.
  21. Liu H, Kuo H. Intravesical botulinum toxin A injections plus hydrodistension can reduce nerve growth factor production and control bladder pain in interstitial cystitis. Urology. 2007;70:463-8 pubmed
    To investigate the level of nerve growth factor (NGF) mRNA in bladder tissue and the effect of botulinum toxin A (BTX-A) treatment in patients with interstitial cystitis (IC).
  22. Erickson D, Tomaszewski J, Kunselman A, Stetter C, Peters K, Rovner E, et al. Urine markers do not predict biopsy findings or presence of bladder ulcers in interstitial cystitis/painful bladder syndrome. J Urol. 2008;179:1850-6 pubmed publisher
    We tested for associations between urine markers, bladder biopsy features and bladder ulcers in interstitial cystitis/painful bladder syndrome.
  23. Kageyama A, Fujino T, Taki Y, Kato Y, Nozawa Y, Ito Y, et al. Alteration of muscarinic and purinergic receptors in urinary bladder of rats with cyclophosphamide-induced interstitial cystitis. Neurosci Lett. 2008;436:81-4 pubmed publisher
    ..of cyclophosphamide (CYP)-treated rats to clarify the mechanisms involved in the pathophysiology of interstitial cystitis (IC)...
  24. Sea J, Teichman J. Paediatric painful bladder syndrome/interstitial cystitis: diagnosis and treatment. Drugs. 2009;69:279-96 pubmed publisher
    ..and controversies surrounding the diagnosis and pharmacological treatments of painful bladder syndrome/interstitial cystitis (PBS/IC) in children, we reviewed adult and paediatric literature pertaining to PBS/IC...
  25. Nickel J, Payne C, Forrest J, Parsons C, Wan G, Xiao X. The relationship among symptoms, sleep disturbances and quality of life in patients with interstitial cystitis. J Urol. 2009;181:2555-61 pubmed publisher
    We conducted a retrospective analysis to determine associations among symptoms, sleep disturbances and quality of life in responder and nonresponder groups of patients with interstitial cystitis.
  26. Danisman A, Kutlu O, Akkaya E, Karpuzoglu G, Erdogru T. Tibial nerve stimulation diminishes mast cell infiltration in the bladder wall induced by interstitial cystitis urine. Scand J Urol Nephrol. 2007;41:98-102 pubmed
    To investigate whether the urine of interstitial cystitis (IC) patients has a toxic effect on the bladder wall, as determined by mast cell infiltration, and to evaluate the preventive effect of tibial nerve electric stimulation (TNES) on ..
  27. Nickel J. Opioids for chronic prostatitis and interstitial cystitis: lessons learned from the 11th World Congress on Pain. Urology. 2006;68:697-701 pubmed
  28. Kahn B, Stanford E, Mishell D, Rosenberg M, Wysocki S. Management of patients with interstitial cystitis or chronic pelvic pain of bladder origin: a consensus report. Curr Med Res Opin. 2005;21:509-16 pubmed
    b>Interstitial cystitis (IC) remains a challenging disease to treat, but increased awareness, better diagnostic tools, and effective pharmacologic agents can help non-urologists successfully manage this condition...
  29. Rosenberg M, Hazzard M. Prevalence of interstitial cystitis symptoms in women: a population based study in the primary care office. J Urol. 2005;174:2231-4 pubmed
    We estimated the prevalence of urinary symptoms related to interstitial cystitis (IC) in women in a primary care practice and confirmed in the United States the results of a Finnish population based prevalence study.
  30. Wu E, Birnbaum H, Kang Y, Parece A, Mallett D, Taitel H, et al. A retrospective claims database analysis to assess patterns of interstitial cystitis diagnosis. Curr Med Res Opin. 2006;22:495-500 pubmed
    b>Interstitial cystitis (IC) is often misdiagnosed as one of several other conditions manifesting similar symptoms...
  31. Clemens J, Brown S, Kozloff L, Calhoun E. Predictors of symptom severity in patients with chronic prostatitis and interstitial cystitis. J Urol. 2006;175:963-6; discussion 967 pubmed
    ..Numerous studies have been performed to identify potential risk factors for CP/CPPS and IC. However, few studies have been done to identify predictors of disease severity...
  32. Warren J, Howard F, Cross R, Good J, Weissman M, Wesselmann U, et al. Antecedent nonbladder syndromes in case-control study of interstitial cystitis/painful bladder syndrome. Urology. 2009;73:52-7 pubmed publisher
    Probing for clues to the pathogenesis of interstitial cystitis/painful bladder syndrome (IC/PBS), we sought antecedent nonbladder syndromes that distinguished incident IC/PBS cases from matched controls.
  33. Erickson D, Schwarze S, Dixon J, Clark C, Hersh M. Differentiation associated changes in gene expression profiles of interstitial cystitis and control urothelial cells. J Urol. 2008;180:2681-7 pubmed publisher
    We evaluated gene expression profiles after inducing differentiation in cultured interstitial cystitis and control urothelial cells.
  34. Saban R, Saban M, Maier J, Fowler B, Tengowski M, Davis C, et al. Urothelial expression of neuropilins and VEGF receptors in control and interstitial cystitis patients. Am J Physiol Renal Physiol. 2008;295:F1613-23 pubmed publisher
    b>Interstitial cystitis (IC) is a chronic and painful bladder syndrome of unknown cause with no reliable biological marker or effective therapy...
  35. Ness T, Powell Boone T, Cannon R, Lloyd L, Fillingim R. Psychophysical evidence of hypersensitivity in subjects with interstitial cystitis. J Urol. 2005;173:1983-7 pubmed
    We quantified differences in somatic and visceral sensation in healthy subjects and subjects with interstitial cystitis (IC).
  36. Peters K, Carrico D, Diokno A. Characterization of a clinical cohort of 87 women with interstitial cystitis/painful bladder syndrome. Urology. 2008;71:634-40 pubmed publisher
    To provide a characterization of a cohort of women with interstitial cystitis/painful bladder syndrome (IC/PBS) by describing their historical and clinical characteristics...
  37. Cameron A, Gajewski J. Bladder outlet obstruction in painful bladder syndrome/interstitial cystitis. Neurourol Urodyn. 2009;28:944-8 pubmed publisher
    ..symptoms such as slow stream, dribbling and straining are often reported by painful bladder syndrome and interstitial cystitis (PBS/IC) patients...
  38. Nordling J. Interstitial cystitis: how should we diagnose it and treat it in 2004?. Curr Opin Urol. 2004;14:323-7 pubmed
    ..international and two European meetings have taken place and a European Society formed dealing only with interstitial cystitis. A separate committee for interstitial cystitis was formed during the last WHO International Consensus ..
  39. Fitzgerald M, Koch D, Senka J. Visceral and cutaneous sensory testing in patients with painful bladder syndrome. Neurourol Urodyn. 2005;24:627-32 pubmed
  40. Davis E, El Khoudary S, Talbott E, Davis J, Regan L. Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial. J Urol. 2008;179:177-85 pubmed
    We examined the safety and the efficacy of a combination of intravesical and oral pentosan polysulfate sodium in comparison to only oral pentosan polysulfate sodium in treating interstitial cystitis.
  41. Ingber M, Peters K, Killinger K, Carrico D, Ibrahim I, Diokno A. Dilemmas in diagnosing pelvic pain: multiple pelvic surgeries common in women with interstitial cystitis. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19:341-5 pubmed
    We determined the prevalence of pelvic surgeries in women with interstitial cystitis (IC) compared to community-based controls through responses to a survey from 215 women with IC and 823 controls...
  42. Kutlu O, Akkaya E, Koksal I, Bassorgun I, Ciftcioglu M, Sanlioglu S, et al. Importance of TNF-related apoptosis-inducing ligand in pathogenesis of interstitial cystitis. Int Urol Nephrol. 2010;42:393-9 pubmed publisher
    Although interstitial cystitis is an inflammatory disease, its etiopathogenesis is not clearly understood...
  43. Nickel J, Tripp D, Pontari M, Moldwin R, Mayer R, Carr L, et al. Psychosocial phenotyping in women with interstitial cystitis/painful bladder syndrome: a case control study. J Urol. 2010;183:167-72 pubmed publisher
    We characterized and compared psychosocial phenotypes in a female interstitial cystitis/painful bladder syndrome cohort and an age matched cohort without that diagnosis.
  44. Lokeshwar V, Selzer M, Unwala D, Estrella V, Gomez M, Golshani R, et al. Uronate peaks and urinary hyaluronic acid levels correlate with interstitial cystitis severity. J Urol. 2006;176:1001-7 pubmed
    ..a basic component of urothelial glycosaminoglycans, are increased in urine specimens of patients with interstitial cystitis with severe symptoms...
  45. Peters K, Kalinowski S, Carrico D, Ibrahim I, Diokno A. Fact or fiction--is abuse prevalent in patients with interstitial cystitis? Results from a community survey and clinic population. J Urol. 2007;178:891-5; discussion 895 pubmed
    We determined whether abuse is associated with interstitial cystitis by surveying patients with interstitial cystitis and controls. We corroborated this association in a clinic population.
  46. Mayer R. Interstitial cystitis pathogenesis and treatment. Curr Opin Infect Dis. 2007;20:77-82 pubmed
    b>Interstitial cystitis remains an idiopathic illness characterized by urinary frequency, urgency and pelvic pain with substantial morbidity in those affected...
  47. Tincello D, Walker A. Interstitial cystitis in the UK: results of a questionnaire survey of members of the Interstitial Cystitis Support Group. Eur J Obstet Gynecol Reprod Biol. 2005;118:91-5 pubmed
    To examine the site, severity, and duration, of symptoms in patients with interstitial cystitis. To examine the treatments offered.
  48. Hanno P, Dmochowski R. Status of international consensus on interstitial cystitis/bladder pain syndrome/painful bladder syndrome: 2008 snapshot. Neurourol Urodyn. 2009;28:274-86 pubmed publisher
    ..have been ongoing efforts around the world to standardize nomenclature, definition, and evaluation of interstitial cystitis/bladder pain syndrome/painful bladder syndrome...
  49. Canter M, Graham C, Heit M, Blackwell L, Wilkey D, Klein J, et al. Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects. Am J Obstet Gynecol. 2008;198:553.e1-6 pubmed publisher
    The purpose of this study was to identify differences in urine proteins between patients with interstitial cystitis (IC) and asymptomatic control (AC) subjects with the use of proteomic techniques.
  50. Sculptoreanu A, de Groat W, Buffington C, Birder L. Protein kinase C contributes to abnormal capsaicin responses in DRG neurons from cats with feline interstitial cystitis. Neurosci Lett. 2005;381:42-6 pubmed
    b>Interstitial cystitis (IC) is a painful disorder which affects urinary bladder function in cats and humans...
  51. Rose A, Payne C, Azevedo K. Pilot study of the feasibility of in-office bladder distention using electromotive drug adminstration (EMDA). Neurourol Urodyn. 2005;24:254-60 pubmed
    Cystoscopic bladder distention is an important tool in the diagnosis and treatment of interstitial cystitis (IC)...
  52. Zhang Q, Shen X, Zhou Z, Chen Z, Lu G, Song B. Decreased nanobacteria levels and symptoms of nanobacteria-associated interstitial cystitis/painful bladder syndrome after tetracycline treatment. Int Urogynecol J. 2010;21:103-9 pubmed publisher
    ..designed to detect whether nanobacteria (NB) reside in urine and bladder tissue samples of patients with interstitial cystitis/painful bladder syndrome (IC/PBS) and whether antibiotic therapy targeting these organisms is effective in ..
  53. El Khoudary S, Talbott E, Bromberger J, Chang C, Songer T, Davis E. Severity of interstitial cystitis symptoms and quality of life in female patients. J Womens Health (Larchmt). 2009;18:1361-8 pubmed publisher
    b>Interstitial cystitis (IC) is a visceral pain syndrome with a profound impact on quality of life (QOL)...
  54. Homma Y, Ueda T, Tomoe H, Lin A, Kuo H, Lee M, et al. Clinical guidelines for interstitial cystitis and hypersensitive bladder syndrome. Int J Urol. 2009;16:597-615 pubmed publisher
    A clinical guideline and algorism for interstitial cystitis and hypersensitive bladder syndrome has been developed by a group of East Asian urologists as a revised form of the Japanese guideline for interstitial cystitis...
  55. Clemens J, Meenan R, O Keeffe Rosetti M, Brown S, Gao S, Calhoun E. Prevalence of interstitial cystitis symptoms in a managed care population. J Urol. 2005;174:576-80 pubmed
    We calculated the prevalence of symptoms typically associated with interstitial cystitis (IC) in men and women in a managed care population in the Pacific Northwest.
  56. Makino T, Kawashima H, Konishi H, Nakatani T, Kiyama H. Elevated urinary levels and urothelial expression of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein in patients with interstitial cystitis. Urology. 2010;75:933-7 pubmed publisher
    To investigate the pathophysiology of interstitial cystitis (IC), we examined urinary levels and urothelial expression of human orthologue of pancreatitis-associated protein (PAP) III, namely, hepatocarcinoma-intestine-pancreas (HIP)/PAP,..
  57. Clemens J, Meenan R, Rosetti M, Gao S, Calhoun E. Prevalence and incidence of interstitial cystitis in a managed care population. J Urol. 2005;173:98-102; discussion 102 pubmed
    We calculated the prevalence and incidence of physician diagnosed interstitial cystitis (IC) in men and women in a managed care population in the Pacific Northwest.
  58. Warren J, Brown J, Tracy J, Langenberg P, Wesselmann U, Greenberg P. Evidence-based criteria for pain of interstitial cystitis/painful bladder syndrome in women. Urology. 2008;71:444-8 pubmed publisher
    No diagnostic physical signs, urologic findings, or laboratory tests are available for interstitial cystitis/painful bladder syndrome (IC/PBS). Its diagnosis is determined by symptoms and the exclusion of mimicking diseases...
  59. Stanford E, Koziol J, Feng A. The prevalence of interstitial cystitis, endometriosis, adhesions, and vulvar pain in women with chronic pelvic pain. J Minim Invasive Gynecol. 2005;12:43-9 pubmed
    ..To estimate the prevalence of bladder-origin pain, intraperitoneal pathology, and vulvar pain in patients undergoing laparoscopy for chronic pelvic pain (CPP)...
  60. Al Hadithi H, Williams H, Hart C, Frazer M, Adams E, Richmond D, et al. Absence of bacterial and viral DNA in bladder biopsies from patients with interstitial cystitis/chronic pelvic pain syndrome. J Urol. 2005;174:151-4 pubmed
    We examined bladder biopsies from women with interstitial cystitis/chronic pelvic pain syndrome (IC/CPPS) for the presence of bacterial and viral DNA sequences using polymerase chain reaction.
  61. Welk B, Teichman J. Dyspareunia response in patients with interstitial cystitis treated with intravesical lidocaine, bicarbonate, and heparin. Urology. 2008;71:67-70 pubmed publisher
    To test the dyspareunia response of patients with interstitial cystitis/painful bladder syndrome treated with an intravesical therapeutic solution of lidocaine, heparin, and sodium bicarbonate.
  62. Butrick C. Patients with chronic pelvic pain: endometriosis or interstitial cystitis/painful bladder syndrome?. JSLS. 2007;11:182-9 pubmed
    Endometriosis and interstitial cystitis/painful bladder syndrome share similar symptoms. Interstitial cystitis was once considered rare, but it is now recognized as more common than previously thought...
  63. Kushner L, Moldwin R. Efficiency of questionnaires used to screen for interstitial cystitis. J Urol. 2006;176:587-92 pubmed
    Questionnaires for the evaluation of interstitial cystitis are widely used, but their value in discriminating interstitial cystitis from other diagnoses among patients with urological symptoms has not been determined...
  64. Moldwin R, Evans R, Stanford E, Rosenberg M. Rational approaches to the treatment of patients with interstitial cystitis. Urology. 2007;69:73-81 pubmed
    Symptoms of interstitial cystitis can usually be successfully managed with heparinoid therapy to theoretically alter bladder urothelial abnormalities, and with oral medications to inhibit neural upregulation or to control mast cell ..
  65. Iavazzo C, Athanasiou S, Pitsouni E, Falagas M. Hyaluronic acid: an effective alternative treatment of interstitial cystitis, recurrent urinary tract infections, and hemorrhagic cystitis?. Eur Urol. 2007;51:1534-40; discussion 1540-1 pubmed
    ..This damage is proposed to be a causative factor in the development of interstitial cystitis, common urinary tract infections, and hemorrhagic cystitis due to posthematopoietic stem cell ..
  66. Kaczmarek P, Keay S, Tocci G, Koch K, Zhang C, Barchi J, et al. Structure-activity relationship studies for the peptide portion of the bladder epithelial cell antiproliferative factor from interstitial cystitis patients. J Med Chem. 2008;51:5974-83 pubmed publisher
    ..These data provide critical guidelines for optimization of structure in design of APF analogues as potential therapeutic agents...
  67. Paulson J, Delgado M. The relationship between interstitial cystitis and endometriosis in patients with chronic pelvic pain. JSLS. 2007;11:175-81 pubmed
    This study was designed to determine the relationship between interstitial cystitis (IC), endometriosis (endo), and chronic pelvic pain (CPP) in individuals in whom nongynecological and nonurological problems had been previously ruled out.
  68. Temml C, Wehrberger C, Riedl C, Ponholzer A, Marszalek M, Madersbacher S. Prevalence and correlates for interstitial cystitis symptoms in women participating in a health screening project. Eur Urol. 2007;51:803-8; discussion 809 pubmed
    To determine the prevalence of interstitial cystitis (IC) symptoms in an urban female population, to study their impact on quality of life and sexual function, and to identify correlates for IC symptoms.
  69. Peters K, Killinger K, Ibrahim I. Childhood symptoms and events in women with interstitial cystitis/painful bladder syndrome. Urology. 2009;73:258-62 pubmed publisher
    ..tract infection and elimination difficulties experienced in childhood and adolescence in adult women with interstitial cystitis/painful bladder syndrome (IC/PBS) and community controls...
  70. Clemens J, Markossian T, Calhoun E. Comparison of economic impact of chronic prostatitis/chronic pelvic pain syndrome and interstitial cystitis/painful bladder syndrome. Urology. 2009;73:743-6 pubmed publisher
    ..a comparison of the economic impact of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and interstitial cystitis/painful bladder syndrome (IC/PBS) because limited information is available...
  71. Sand P. Proposed pathogenesis of painful bladder syndrome/interstitial cystitis. J Reprod Med. 2006;51:234-40 pubmed
  72. Jacobs B, Smaldone M, Tyagi V, Philips B, Jackman S, Leng W, et al. Increased nerve growth factor in neurogenic overactive bladder and interstitial cystitis patients. Can J Urol. 2010;17:4989-94 pubmed
    ..We evaluated urine nerve growth factor (NGF) levels from patients with a variety of urologic conditions to examine NGF's role as a future biomarker...