acute kidney tubular necrosis

Summary

Summary: Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.

Top Publications

  1. Goldfarb M, Rosenberger C, Abassi Z, Shina A, Zilbersat F, Eckardt K, et al. Acute-on-chronic renal failure in the rat: functional compensation and hypoxia tolerance. Am J Nephrol. 2006;26:22-33 pubmed
    ..We hypothesized that chronic renal parenchymal disease may predispose to acute renal failure (ARF), facilitating the induction of hypoxic medullary tubular injury...
  2. Fukuhara N, Ono Y, Hattori R, Nishiyama N, Yamada S, Kamihira O, et al. The long-term outcome of tacrolimus in cadaveric kidney transplantation from non-heart beating donors. Clin Transplant. 2005;19:153-7 pubmed
    ..This indicates that Tac is available for cadaveric kidney transplants from non-heart beating donors. In conclusion, Tac is available as an immunosuppressive agent even for kidney transplants from non-heart beating donors...
  3. Santamaria R, Espinosa M, Ortega R, Lopez Rubio F, Sanchez J, Torres A, et al. [Acute renal failure in a patient with myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria phenotype]. Nefrologia. 2004;24 Suppl 3:56-60 pubmed
    ..This case underlines the nephrotoxic role of heme pigment and iron, and possible pathophysiologic mechanisms involved in acute and chronic toxicity of both agents are reviewed...
  4. Mori T, Cowley A. Role of pressure in angiotensin II-induced renal injury: chronic servo-control of renal perfusion pressure in rats. Hypertension. 2004;43:752-9 pubmed
    ..We conclude that the preferential juxtamedullary injury found in Ang II hypertension is largely induced by pressure and is probably mediated through the TGF-beta and NF-kappaB pathway...
  5. Kaneoka H, Uesugi N, Moriguchi A, Hirose S, Takayanagi M, Yamaguchi S, et al. Carnitine palmitoyltransferase II deficiency due to a novel gene variant in a patient with rhabdomyolysis and ARF. Am J Kidney Dis. 2005;45:596-602 pubmed
    ..Genetic analysis of the patient identified a novel variant of the CPT II gene...
  6. Dragun D, Bohler T, Nieminen Kelhä M, Waiser J, Schneider W, Haller H, et al. FTY720-induced lymphocyte homing modulates post-transplant preservation/reperfusion injury. Kidney Int. 2004;65:1076-83 pubmed
    ..We tested whether or not single-dose FTY720 (0.5 mg/kg) pretreatment rescues renal grafts from post-transplant preservation/reperfusion injury...
  7. du Cheyron D, Daubin C, Poggioli J, Ramakers M, Houillier P, Charbonneau P, et al. Urinary measurement of Na+/H+ exchanger isoform 3 (NHE3) protein as new marker of tubule injury in critically ill patients with ARF. Am J Kidney Dis. 2003;42:497-506 pubmed
  8. Tolwani A. Renal replacement therapies for acute renal failure: does dose matter?. Am J Kidney Dis. 2005;45:1139-43 pubmed
  9. Quintana L, Cofan F, Reverté J, Oppenheimer F, Campistol J. Renal cortical necrosis after kidney transplantation associated with the prothrombin 20210A mutation. Nephrol Dial Transplant. 2006;21:1455-6 pubmed

More Information

Publications62

  1. Tanenbaum N, Howell D, Middleton J, Spurney R. Lambda light chain deposition disease in a renal allograft. Transplant Proc. 2005;37:4289-92 pubmed
    ..We present a case of LCDD caused by deposition of lambda light chains in a patient who received a cadaveric renal transplant...
  2. Browne R, Tuite D. Imaging of the renal transplant: comparison of MRI with duplex sonography. Abdom Imaging. 2006;31:461-82 pubmed
  3. Homsi E, Ribeiro Alves M, Lopes de Faria J, Dias E. Interleukin-6 stimulates tubular regeneration in rats with glycerol-induced acute renal failure. Nephron. 2002;92:192-9 pubmed
    ..Interleukin-6 stimulates tubular regeneration in rats with glycerol-induced acute renal failure...
  4. Volpini R, Balbi A, Costa R, Coimbra T. Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin. Braz J Med Biol Res. 2006;39:817-23 pubmed
    ..The increased expression of p-p38 MAPK and NF-kappaB observed in these rats suggests that these signaling molecules may be involved in the pathogenesis of tubulointerstitial nephritis induced by gentamicin...
  5. Chaiwatanarat T, Laorpatanaskul S, Poshyachinda M, Boonvisut S, Buachum V, Krisanachinda A, et al. Deconvolution analysis of renal blood flow: evaluation of postrenal transplant complications. J Nucl Med. 1994;35:1792-6 pubmed
    ..To differentiate acute tubular necrosis from acute rejection when it occurs in the early posttransplant period is difficult. Renal scintigraphy offers a noninvasive means for renal blood flow (RBF) and renal function assessment...
  6. Veselsky Z, Macek P, Navratil P, Fixa P, Psohlavec J, Forstl M. [Comparison of 2 methods of diagnosis of changes in transplanted kidneys in the early postoperative period: biopsy vs dynamic scintigraphy of the graft]. Rozhl Chir. 2001;80:361-3 pubmed
    ..Their attention is focused on the technique and risks of renal biopsy...
  7. Varghese S, Powell T, Janech M, Budisavljevic M, Stanislaus R, Almeida J, et al. Identification of diagnostic urinary biomarkers for acute kidney injury. J Investig Med. 2010;58:612-20 pubmed publisher
    ..Plasma retinol-binding protein was identified in 1 spot and a fragment of albumin and plasma retinol-binding protein in the other. These proteins are candidate markers for diagnostic assays of AKI. ..
  8. Kobuchi S, Shintani T, Sugiura T, Tanaka R, Suzuki R, Tsutsui H, et al. Renoprotective effects of gamma-aminobutyric acid on ischemia/reperfusion-induced renal injury in rats. Eur J Pharmacol. 2009;623:113-8 pubmed publisher
  9. Furuichi K, Wada T, Iwata Y, Kokubo S, Hara A, Yamahana J, et al. Interleukin-1-dependent sequential chemokine expression and inflammatory cell infiltration in ischemia-reperfusion injury. Crit Care Med. 2006;34:2447-55 pubmed
    ..Inflammation is a factor in tissue destruction in ischemia reperfusion injury, and interleukin (IL)-1 is a key promoter of inflammation...
  10. Xie Y, Nishi S, Iguchi S, Imai N, Sakatsume M, Saito A, et al. Expression of osteopontin in gentamicin-induced acute tubular necrosis and its recovery process. Kidney Int. 2001;59:959-74 pubmed
    ..There is little information on the expression and role of OPN in gentamicin-induced acute tubular necrosis (ATN) and its recovery process...
  11. Rabb H, Daniels F, O Donnell M, Haq M, Saba S, Keane W, et al. Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice. Am J Physiol Renal Physiol. 2000;279:F525-31 pubmed
    ..These data suggest that T lymphocytes can mediate experimental renal IRI. Moreover, adhesion of infiltrating T cells to renal tubular cells may provide a potential mechanism underlying postischemic tubular dysfunction...
  12. Fujigaki Y, Goto T, Sakakima M, Fukasawa H, Miyaji T, Yamamoto T, et al. Kinetics and characterization of initially regenerating proximal tubules in S3 segment in response to various degrees of acute tubular injury. Nephrol Dial Transplant. 2006;21:41-50 pubmed
    ..We examined kinetics and characterization of regenerating proximal tubule (PT) cells after various degrees of tubular injury in S3 segments of PT and assessed label-retaining slow cycling cells in S3...
  13. Browning M. Effect of verapamil on cephaloridine nephrotoxicity in the rabbit. Toxicol Appl Pharmacol. 1990;103:383-8 pubmed
    ..We conclude that verapamil does not protect renal proximal tubular cells from the toxic effect of cephaloridine, and that verapamil prevents the cephaloridine-induced uptake of calcium by cortical mitochondria...
  14. Novak K, Le H, Christison Lagay E, Nose V, Doiron R, Moses M, et al. Effects of metalloproteinase inhibition in a murine model of renal ischemia-reperfusion injury. Pediatr Res. 2010;67:257-62 pubmed publisher
    ..99); however, pretreated mice presented only a slight increase in mean MMP-2 activity (1.57 +/- 0.72) (p < 0.001). In conclusion, these data demonstrate that MMP inhibition is associated with a reduction of IRI in a murine model...
  15. Zhou L, Fu P, Huang X, Liu F, Lai K, Lan H. Activation of p53 promotes renal injury in acute aristolochic acid nephropathy. J Am Soc Nephrol. 2010;21:31-41 pubmed publisher
    ..Taken together, these results suggest that AA induces TEC death via apoptosis by dephosphorylation of STAT3 and posttranslational activation of p53, supporting the hypothesis that p53 promotes renal injury in acute AAN...
  16. Weisbord S, Palevsky P. Radiocontrast-induced acute renal failure. J Intensive Care Med. 2005;20:63-75 pubmed
    ..Studies evaluating N-acetylcysteine have been conflicting, with meta-analyses suggesting a small beneficial effect. Studies of other pharmacologic agents have not demonstrated clinical benefit...
  17. Mariat C. [Diagnosis and follow-up of chronic kidney graft dysfunction: from DFG to new biomarkers]. Nephrol Ther. 2008;4 Suppl 3:S204-7 pubmed publisher
    ..Yet the advantages of these biomarkers in predicting the evolving complications of chronic allograft dysfunction as well as graft loss on the individual level now require validation...
  18. Cassis T, Jackson J, Sonnier G, Callen J. Nephrogenic fibrosing dermopathy in a patient with acute renal failure never requiring dialysis. Int J Dermatol. 2006;45:56-9 pubmed
    ..We also review the four other cases of acute NFD never requiring dialysis that have been reported in the literature...
  19. Allory Y, Audard V, Fontanges P, Ronco P, Debiec H. The L1 cell adhesion molecule is a potential biomarker of human distal nephron injury in acute tubular necrosis. Kidney Int. 2008;73:751-8 pubmed
    ..Our study shows that a soluble form of human L1 can be detected in the urine of patients with acute tubular necrosis and that this may be a marker of distal nephron injury...
  20. Ozkaya O, Yavuz O, Can B, Dilek M, Savli E, Acikgoz Y, et al. Effect of rosiglitazone on cisplatin-induced nephrotoxicity. Ren Fail. 2010;32:368-71 pubmed publisher
    ..The aim of this study was to evaluate the effect of Ros on the prevention of Cis-induced nephrotoxicity...
  21. Fernandez A, Royuela A, Quintas A, Zamora J. [Are IL2 receptor antagonist useful in high risk acute tubular necrosis kidney recipients?]. Nefrologia. 2007;27:534-6 pubmed
    ..The odds ratio for delayed graft function was 0.87(IC 95% 0,72 a 1,06). Therefore, at the moment, we can conclude that the utilization of antagonists of Il-2 receptors does not have protective effect to NTA...
  22. Kharasch E, Frink E, Zager R, Bowdle T, Artru A, Nogami W. Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity. Anesthesiology. 1997;86:1238-53 pubmed
  23. Levine S, Saltzman A. Hydropic degeneration of the anterior pituitary gland (adenohypophysis) in uremic rats. Toxicol Lett. 2004;147:121-6 pubmed
    ..Morphologic lesions of the anterior pituitary related to hyponatremia and uremia have not been described previously...
  24. Feith G, Assmann K, Wetzels J. Acute renal failure in patients with glomerular diseases: a consequence of tubular cell damage caused by haematuria?. Neth J Med. 2003;61:146-50 pubmed
    ..Recognition of this entity will prevent unnecessary long-term immunosuppressive therapy...
  25. Meldrum K, Hile K, Meldrum D, Crone J, Gearhart J, Burnett A. Simulated ischemia induces renal tubular cell apoptosis through a nuclear factor-kappaB dependent mechanism. J Urol. 2002;168:248-52 pubmed
    ..While nuclear factor-kappaB has been implicated in the pathophysiology of renal ischemia-reperfusion injury, the effect of nuclear factor-kappaB inhibition on ischemia induced renal tubular cell death remains unknown...
  26. Acker C, Flick R, Shapiro R, Scantlebury V, Jordan M, Vivas C, et al. Thyroid hormone in the treatment of post-transplant acute tubular necrosis (ATN). Am J Transplant. 2002;2:57-61 pubmed
    ..Long-term graft function is impaired in patients who experience post-transplant DGF compared to those who have good initial function...
  27. Koizumi K, Kakiuchi H, Saguchi T, Inoue S, Fuse S, Kawakami E, et al. A simple objective parameter for perfusion study of renal transplant. Ann Nucl Med. 2001;15:27-32 pubmed
    ..In conclusion, KAR is a simple and practically useful parameter for objective evaluation and follow-up of renal transplant perfusion...
  28. Yee A, Pochapin M. Treatment of complicated sarcoidosis with infliximab anti-tumor necrosis factor-alpha therapy. Ann Intern Med. 2001;135:27-31 pubmed
    ..Tumor necrosis factor-alpha (TNF-alpha) may have an important role in the clinical exacerbation of sarcoidosis...
  29. Bellomo R, Bagshaw S, Langenberg C, Ronco C. Pre-renal azotemia: a flawed paradigm in critically ill septic patients?. Contrib Nephrol. 2007;156:1-9 pubmed
  30. Shorten G. [Fenoldopam: potential clinical applications in heart surgery]. Rev Esp Anestesiol Reanim. 2001;48:487-91 pubmed
    ..Intravenous fenoldopam mesylate significantly increased renal blood flow and decreased vascular resistance in healthy volunteers and hypertensive patients...
  31. Sadeghi M, Daniel V, Naujokat C, Mehrabi A, Opelz G. Association of high pretransplant sIL-6R plasma levels with acute tubular necrosis in kidney graft recipients. Transplantation. 2006;81:1716-24 pubmed
  32. Docherty N, Lopez Novoa J, Arevalo M, Düwel A, Rodriguez Peña A, Perez Barriocanal F, et al. Endoglin regulates renal ischaemia-reperfusion injury. Nephrol Dial Transplant. 2006;21:2106-19 pubmed
    ..Endoglin, an accessory receptor for Transforming Growth Factor-beta1 (TGF-beta1), is expressed on activated endothelium during macrophage maturation and implicated in the control of fibrosis, angiogenesis and inflammation...
  33. Kanjanabuch T, Sitprija V. Snakebite nephrotoxicity in Asia. Semin Nephrol. 2008;28:363-72 pubmed publisher
    ..Enzymatic activities of snake venoms account for direct nephrotoxicity. Immunologic mechanism plays a minor role...
  34. Yang C, Kim B, Kim J, Ahn H, Park J, Jin D, et al. Preconditioning with sodium arsenite inhibits apoptotic cell death in rat kidney with ischemia/reperfusion or cyclosporine-induced Injuries. The possible role of heat-shock protein 70 as a mediator of ischemic tolerance. Exp Nephrol. 2001;9:284-94 pubmed
    ..In conclusion, SA pretreatment prevents subsequent I/R or CsA-induced injuries in the rat kidney, and this renoprotective effect appears to be mediated by induction of HSP70...
  35. Pinotti G, Martinelli B. A case of acute tubular necrosis due to oxaliplatin. Ann Oncol. 2002;13:1951-2 pubmed
  36. Hanigan M, Gallagher B, Townsend D, Gabarra V. Gamma-glutamyl transpeptidase accelerates tumor growth and increases the resistance of tumors to cisplatin in vivo. Carcinogenesis. 1999;20:553-9 pubmed
    ..These results indicate that the nephrotoxicity and the tumor toxicity of cisplatin are via two distinct pathways...
  37. Osman Y, Shokeir A, Ali el Dein B, Tantawy M, Wafa E, El Dein A, et al. Vascular complications after live donor renal transplantation: study of risk factors and effects on graft and patient survival. J Urol. 2003;169:859-62 pubmed
    ..We evaluated the incidence and management of vascular complications after live donor renal transplantation. Possible risk factors and their effects on patient and graft survival were also assessed...
  38. Haq M, Norman J, Saba S, Ramirez G, Rabb H. Role of IL-1 in renal ischemic reperfusion injury. J Am Soc Nephrol. 1998;9:614-9 pubmed
    ..05) h. Recovery in the IL-1Ra group was similar to that in the control animals. These data demonstrate that IL-1 is unlikely to be beneficial in the recovery of renal function after ischemia and may play a deleterious role...
  39. Labaye J, Sarret D, Duvic C, Herody M, Didelot F, Nedelec G, et al. Renal toxicity of oxaliplatin. Nephrol Dial Transplant. 2005;20:1275-6 pubmed
  40. Smetana S, Michlin A, Rosenman E, Biro A, Boaz M, Katzir Z. Pamidronate-induced nephrotoxic tubular necrosis--a case report. Clin Nephrol. 2004;61:63-7 pubmed
    ..The acute pattern of renal failure resolved following cessation of pamidronate administration in this patient for osteoporosis; the patient also had a monoclonal gammopathy of unspecific origin (MGUS)...
  41. Kelly D, Zhang Y, Gow R, Gilbert R. Tranilast attenuates structural and functional aspects of renal injury in the remnant kidney model. J Am Soc Nephrol. 2004;15:2619-29 pubmed
    ..In the context of a recent pilot study in humans, the findings of the present report suggest that tranilast may provide a novel strategy for the treatment of progressive kidney disease characterized by fibrotic scarring...
  42. Rivers B, Walter P, Holm J, Letourneau J, Finlay D, Ritenour E, et al. Gray-scale sonographic characterization of aminoglycoside-induced nephrotoxicosis in a canine model. Invest Radiol. 1996;31:639-51 pubmed
    ..The diagnostic usefulness of gray-scale sonography was evaluated in a canine model of aminoglycoside-induced nephrotoxicosis...
  43. Módis K, Gero D, Nagy N, Szoleczky P, Tóth Z, Szabo C. Cytoprotective effects of adenosine and inosine in an in vitro model of acute tubular necrosis. Br J Pharmacol. 2009;158:1565-78 pubmed publisher
    ..We have established an in vitro model of acute tubular necrosis in rat kidney tubular cells, using combined oxygen-glucose deprivation (COGD) and screened a library of 1280 pharmacologically active compounds for cytoprotective effects...
  44. Yen T, Alison M, Cook H, Jeffery R, Otto W, Wright N, et al. The cellular origin and proliferative status of regenerating renal parenchyma after mercuric chloride damage and erythropoietin treatment. Cell Prolif. 2007;40:143-56 pubmed
  45. Pradère C, Planchard D, Plouzeau C, Merlet Chicoine I, Valero S, Paccalin M. Acute tubular necrosis due to rhabdomyolysis resulting from influenza A infection. J Am Geriatr Soc. 2006;54:725 pubmed
  46. Mathur V. Pathophysiology of radiocontrast nephropathy and use of fenoldopam for its prevention. Rev Cardiovasc Med. 2001;2 Suppl 1:S4-8 pubmed
  47. Kopple J, Ding H, Letoha A, Ivanyi B, Qing D, Dux L, et al. L-carnitine ameliorates gentamicin-induced renal injury in rats. Nephrol Dial Transplant. 2002;17:2122-31 pubmed
    ..This study examined whether administration of L-carnitine ameliorates gentamicin-induced renal injury in rats...
  48. Ladinsky G, Goral S. Macroscopic hematuria in a kidney transplant recipient: a rare cause. Am J Kidney Dis. 2006;47:e3-7 pubmed
    ..A high index of suspicion, along with early diagnosis and transcatheter embolization, are essential for the management of hematuria caused by pseudoaneurysm formation from percutaneous nephrostomy tube placement...
  49. Cofan F, Torregrosa J. [Clinical management of the living donor kidney transplant recipient]. Arch Esp Urol. 2005;58:531-6 pubmed
    ..In living donor RT a rapid normalization of the renal function and a time of hospitalization reduced are observed. The presence of a long ATN or a renal dysfunction of the graft must force to realize an early renal allograft biopsy...
  50. Longstreth K, Robbins S, Smavatkul C, Doe N. Cephalexin-induced acute tubular necrosis. Pharmacotherapy. 2004;24:808-11 pubmed
    ..6 mg/dl. Although the renal injury most commonly associated with the cephalosporin class of antibiotics is allergic interstitial nephritis, currently available cephalosporins infrequently can cause direct tubular toxicity...
  51. Han W, Bonventre J. Biologic markers for the early detection of acute kidney injury. Curr Opin Crit Care. 2004;10:476-82 pubmed
    ..This review discusses the current status of several biomarkers as potential diagnostic tools in patients with acute kidney disease...
  52. Inagaki H, Takeda A, Sato T, Watanabe I, Katayama A, Haba T, et al. Does infiltration of neutrophils in peritubular capillaries indicate humoral rejection? A case displaying a characteristic lesion of a significantly high amount of neutrophils in peritubular capillaries at 1-h graft biopsy during transplant operation. Clin Transplant. 2001;15 Suppl 5:35-40 pubmed
    ..This confirmed that the accumulation of neutrophils in the PTC noted in two recipients was transmitted from the donor kidney. The pathogenesis and clinical significance of neutrophils in the PTC has been shrouded in mystery...
  53. Ysebaert D, De Greef K, Vercauteren S, Verhulst A, Kockx M, Verpooten G, et al. Effect of immunosuppression on damage, leukocyte infiltration, and regeneration after severe warm ischemia/reperfusion renal injury. Kidney Int. 2003;64:864-73 pubmed
    ..Influence of immunosuppressive treatment on post-I/R renal damage, nonalloimmune cellular infiltration, and regeneration is not well studied...