nephrosclerosis

Summary

Summary: Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.

Top Publications

  1. Kincaid Smith P. Hypothesis: obesity and the insulin resistance syndrome play a major role in end-stage renal failure attributed to hypertension and labelled 'hypertensive nephrosclerosis'. J Hypertens. 2004;22:1051-5 pubmed
    ..attributed to hypertension despite controversy about the frequency and pathology of so called hypertensive nephrosclerosis. In spite of good documentation that obesity causes renal failure and in spite of the global epidemic of ..
  2. Imakiire T, Kikuchi Y, Yamada M, Kushiyama T, Higashi K, Hyodo N, et al. Effects of renin-angiotensin system blockade on macrophage infiltration in patients with hypertensive nephrosclerosis. Hypertens Res. 2007;30:635-42 pubmed
    The mechanisms of hypertensive nephrosclerosis are not fully understood. In experimental models of the disease, inflammatory reactions such as macrophage infiltration play an important role...
  3. Hill G. Hypertensive nephrosclerosis. Curr Opin Nephrol Hypertens. 2008;17:266-70 pubmed publisher
    Hypertensive nephrosclerosis is the second most common cause of end-stage renal disease, however morphologic evidence on the subject is poorly understood...
  4. Ying W, Sanders P. Cytochrome c mediates apoptosis in hypertensive nephrosclerosis in Dahl/Rapp rats. Kidney Int. 2001;59:662-72 pubmed
    ..The Dahl/Rapp salt-sensitive (S) rat is a model of low-renin hypertension, but these rats also develop renal lesions that are virtually identical to human hypertensive nephrosclerosis.
  5. Razzaque M, Azouz A, Shinagawa T, Taguchi T. Factors regulating the progression of hypertensive nephrosclerosis. Contrib Nephrol. 2003;139:173-86 pubmed
  6. Neusser M, Lindenmeyer M, Moll A, Segerer S, Edenhofer I, Sen K, et al. Human nephrosclerosis triggers a hypoxia-related glomerulopathy. Am J Pathol. 2010;176:594-607 pubmed publisher
    ..Chronic hypoxia was hypothesized to be involved in nephrosclerosis (NSC) or "hypertensive nephropathy...
  7. Ito Y, Aten J, Nguyen T, Joles J, Matsuo S, Weening J, et al. Involvement of connective tissue growth factor in human and experimental hypertensive nephrosclerosis. Nephron Exp Nephrol. 2011;117:e9-20 pubmed publisher
    ..Connective tissue growth factor (CTGF; CCN2) has been implicated as a marker and mediator of fibrosis in human and experimental renal disease...
  8. Regina S, Lucas R, Miraglia S, Zaladek Gil F, Machado Coimbra T. Intrauterine food restriction as a determinant of nephrosclerosis. Am J Kidney Dis. 2001;37:467-76 pubmed
    ..Our data show that when food restriction is imposed during pregnancy, permanent damage occurs in the kidney of the offspring. Glomerular lesions were more severe than the tubulointerstitial damage in these animals...
  9. Toto R, Greene T, Hebert L, Hiremath L, Lea J, Lewis J, et al. Relationship between body mass index and proteinuria in hypertensive nephrosclerosis: results from the African American Study of Kidney Disease and Hypertension (AASK) cohort. Am J Kidney Dis. 2010;56:896-906 pubmed publisher
    ..We hypothesized that obesity is independently associated with proteinuria, a marker of chronic kidney disease progression...

More Information

Publications62

  1. Zhou X, Ono H, Ono Y, Frohlich E. N- and L-type calcium channel antagonist improves glomerular dynamics, reverses severe nephrosclerosis, and inhibits apoptosis and proliferation in an l-NAME/SHR model. J Hypertens. 2002;20:993-1000 pubmed
    ..calcium antagonist, cilnidipine, on systemic and renal hemodynamics, glomerular dynamics, renal function, and histopathology in an Nomega-nitro-l-arginine methylester spontaneously hypertensive rat (l-NAME/SHR) model of nephrosclerosis.
  2. Nicholson G. Long-term survival after recovery from malignant nephrosclerosis. Am J Hypertens. 1988;1:73-5 pubmed
    Five patients with malignant nephrosclerosis (MNSC) and severe renal failure (mean plasma creatinine 926 micromoles/L) were followed for 52 to 83 months. Blood pressure was controlled by a minoxidil-nadolol-diuretic combination...
  3. Alves T, Wang X, Wright J, Appel L, Greene T, Norris K, et al. Rate of ESRD exceeds mortality among African Americans with hypertensive nephrosclerosis. J Am Soc Nephrol. 2010;21:1361-9 pubmed publisher
    ..death, and a CVD composite (CVD mortality and CVD hospitalization) among participants who had hypertensive nephrosclerosis and were enrolled in the African American Study of Kidney Disease and Hypertension (AASK)...
  4. Okeda R. Pathological changes in the cerebral medullary arteries of five autopsy cases of malignant nephrosclerosis: observation by morphometry and reconstruction of serial sections. Neuropathology. 2003;23:153-60 pubmed
    ..of serial sections and morphometry of the medial thickness in five autopsied patients with malignant nephrosclerosis (MN) of exacerbated form...
  5. Zeller T, Muller C, Frank U, Bürgelin K, Horn B, Schwarzwälder U, et al. Stent angioplasty of severe atherosclerotic ostial renal artery stenosis in patients with diabetes mellitus and nephrosclerosis. Catheter Cardiovasc Interv. 2003;58:510-5 pubmed
    ..after stent angioplasty of ARAS on renal function and blood pressure control in patients with diabetes and nephrosclerosis is the subject of some controversy...
  6. Nishikimi T, Koshikawa S, Ishikawa Y, Akimoto K, Inaba C, Ishimura K, et al. Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats. J Hypertens. 2007;25:1053-63 pubmed
    We examined whether the Rho/Rho-kinase pathway is involved in the pathogenesis of nephrosclerosis in severely hypertensive rats and assessed the effects of long-term treatment with a Rho-kinase inhibitor, fasudil, on kidney function, ..
  7. Wang G, Lai F, Kwan B, Lai K, Chow K, Li P, et al. Expression of ACE and ACE2 in patients with hypertensive nephrosclerosis. Kidney Blood Press Res. 2011;34:141-9 pubmed publisher
    The interplay between intrarenal angiotensin-converting enzyme (ACE) and type 2 ACE (ACE2) might play important roles in the pathogenesis of hypertensive nephrosclerosis (HTN), but human data are limited.
  8. Doi K, Noiri E, Maeda R, Nakao A, Kobayashi S, Tokunaga K, et al. Functional polymorphism of the myeloperoxidase gene in hypertensive nephrosclerosis dialysis patients. Hypertens Res. 2007;30:1193-8 pubmed publisher
    ..reactions but also in local inflammations, especially in atherosclerotic diseases such as hypertensive nephrosclerosis (HN)...
  9. Fung M, Chen Y, Lipkowitz M, Salem R, Bhatnagar V, Mahata M, et al. Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. Nephrol Dial Transplant. 2009;24:3677-86 pubmed publisher
    ..End-stage renal disease (ESRD) due to hypertension is common and displays familial aggregation in African Americans, suggesting genetic risk factors, including adrenergic activity alterations which are noted in both hypertension and ESRD...
  10. Rodriguez Perez J, Losada A, Anabitarte A, Cabrera J, Llobet J, Palop L, et al. Effects of the novel multiple-action agent carvedilol on severe nephrosclerosis in renal ablated rats. J Pharmacol Exp Ther. 1997;283:336-44 pubmed
    ..the use of a new beta adrenoceptor antagonist and vasodilator, carvedilol (CVD), slows the progression of nephrosclerosis and whether the renoprotective effect as well as reduction in cardiac hypertrophy is dependent on the degree ..
  11. Muller D, Klanke B, Feldt S, Cordasic N, Hartner A, Schmieder R, et al. (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. Hypertension. 2008;51:676-81 pubmed publisher
    ..Our results indicate that blockade of the (P)RR with HRP does not improve target organ damage in renovascular hypertensive rats...
  12. Wang G, Kwan B, Lai F, Choi P, Chow K, Li P, et al. Intrarenal expression of miRNAs in patients with hypertensive nephrosclerosis. Am J Hypertens. 2010;23:78-84 pubmed publisher
    ..Previous studies showed that miRNAs targeting transcription factors ZEB1 and ZEB2 may repress epithelial-mesenchymal transition (EMT)...
  13. Wang G, Lai F, Kwan B, Lai K, Chow K, Li P, et al. Podocyte loss in human hypertensive nephrosclerosis. Am J Hypertens. 2009;22:300-6 pubmed publisher
    ..We studied glomerular podocyte count and intrarenal expression of podocyte-associated molecules in patients with hypertensive nephrosclerosis.
  14. Gorostidi M, Marin R. [Renal vascular disease. Concept and meaning. Epidemiology. Essential arterial hypertension and renal failure. Nephrosclerosis. Ischemic or atherosclerotic nephropathy]. Nefrologia. 2004;24 Suppl:73-83, 187-235 pubmed
  15. Koshikawa S, Nishikimi T, Inaba C, Akimoto K, Matsuoka H. Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats. J Hypertens. 2008;26:1837-48 pubmed publisher
    In this study, we tested the hypothesis that long-term Rho-kinase inhibition would reverse nitro-L-arginine methyl ester-exacerbated nephrosclerosis in spontaneously hypertensive rats and attempted to elucidate the mechanism involved.
  16. Lewis J, Agodoa L, Cheek D, Greene T, Middleton J, O Connor D, et al. Comparison of cross-sectional renal function measurements in African Americans with hypertensive nephrosclerosis and of primary formulas to estimate glomerular filtration rate. Am J Kidney Dis. 2001;38:744-53 pubmed
    Renal function measurements were obtained in 1,703 African Americans with presumed hypertensive nephrosclerosis who were screened for entry into the African-American Study of Hypertension and Kidney Disease (AASK)...
  17. Caetano E, Zatz R, Saldanha L, Praxedes J. Hypertensive nephrosclerosis as a relevant cause of chronic renal failure. Hypertension. 2001;38:171-6 pubmed
    It is currently unclear whether hypertensive nephrosclerosis (HN), usually diagnosed solely on clinical grounds, is a relevant cause of end-stage renal disease...
  18. Vasko R, Xavier S, Chen J, Lin C, Ratliff B, Rabadi M, et al. Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence. J Am Soc Nephrol. 2014;25:276-91 pubmed publisher
    ..improved angiogenic and matrilytic functions of the endothelium, prevented renal dysfunction, and attenuated nephrosclerosis. Our findings establish a novel mechanistic molecular link between endothelial SIRT1 depletion, ..
  19. Rule A, Amer H, Cornell L, Taler S, Cosio F, Kremers W, et al. The association between age and nephrosclerosis on renal biopsy among healthy adults. Ann Intern Med. 2010;152:561-7 pubmed publisher
    ..Chronic kidney disease is common with older age and is characterized on renal biopsy by global glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis...
  20. Zhou X, Ono H, Ono Y, Frohlich E. Aldosterone antagonism ameliorates proteinuria and nephrosclerosis independent of glomerular dynamics in L-NAME/SHR model. Am J Nephrol. 2004;24:242-9 pubmed
    ..or angiotensin II receptor antagonists have been demonstrated to afford renoprotection in L-NAME-exacerbated nephrosclerosis in SHR rats...
  21. Takahashi T, Ono H, Ono Y, Ishimitsu T, Matsuoka H. Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1). Int Heart J. 2007;48:637-47 pubmed
    ..The anti-inflammatory and antifibrotic effects due to PPAR-gamma activation and TGF-beta(1) inhibition may participate in the renoprotection of this combination therapy...
  22. Marcantoni C, Ma L, Federspiel C, Fogo A. Hypertensive nephrosclerosis in African Americans versus Caucasians. Kidney Int. 2002;62:172-80 pubmed
    ..To assess and compare severity and phenotype of injury in biopsied African Americans and Caucasians who morphologically had hypertensive nephrosclerosis, we performed a retrospective biopsy study.
  23. Chen G, Lin S, Chen J, He L, Dong F, Xu J, et al. CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis. J Am Soc Nephrol. 2011;22:1876-86 pubmed publisher
    ..In conclusion, CXCL16 contributes to the pathogenesis of renal fibrosis by recruiting bone marrow-derived fibroblast precursors...
  24. Agodoa L, Appel L, Bakris G, Beck G, Bourgoignie J, Briggs J, et al. Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. JAMA. 2001;285:2719-28 pubmed
    ..Incidence of end-stage renal disease due to hypertension has increased in recent decades, but the optimal strategy for treatment of hypertension to prevent renal failure is unknown, especially among African Americans...
  25. Chen Y, Lipkowitz M, Salem R, Fung M, Bhatnagar V, Mahata M, et al. Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. Am J Nephrol. 2010;32:23-30 pubmed publisher
    African-Americans are likely to develop hypertension and hypertensive nephrosclerosis. This grave prognosis, coupled with familial aggregation of end-stage renal disease (ESRD) in Blacks, prompts a search for genetic risk factors for ..
  26. Yokoyama C, Yabuki T, Shimonishi M, Wada M, Hatae T, Ohkawara S, et al. Prostacyclin-deficient mice develop ischemic renal disorders, including nephrosclerosis and renal infarction. Circulation. 2002;106:2397-403 pubmed
    ..To study the role of PGI2 in the vascular system in vivo, PGI2-deficient (PGID) mice were established by genetic disruption of the PGI2 synthase gene...
  27. Bramlage C, Müller G, Tampe B, Bevanda J, Maatouk I, Koziolek M, et al. The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. J Nephrol. 2011;24:647-55 pubmed publisher
    Bone morphogenetic protein-5 (BMP-5) has been shown to be essential for nephrogenesis. Its role in adult kidney and in patients with hypertensive nephrosclerosis is still unknown.
  28. Philbey A, Mateus A, Bexiga R, Barrett D, Haining H, McCandlish I, et al. Renal dysplasia and nephrosclerosis in calves. Vet Rec. 2009;165:626-30 pubmed
    Renal dysplasia and nephrosclerosis in six calves, which were aged three to six months and from different farms in western Scotland and north-west England, was characterised clinically by stunted growth and renal failure with uraemia...
  29. Liang S, Le W, Liang D, Chen H, Xu F, Chen H, et al. Clinico-pathological characteristics and outcomes of patients with biopsy-proven hypertensive nephrosclerosis: a retrospective cohort study. BMC Nephrol. 2016;17:42 pubmed publisher
    This study aimed to investigate renal outcomes and their predictors in biopsy-proven hypertensive nephrosclerosis (HN) patients and to compare clinico-pathological characteristics and prognoses between benign nephrosclerosis (BN) and ..
  30. Staples J, Taylor P, Magil A, Frohlich J, Johnston S, Koschinsky M, et al. Progressive kidney disease in three sisters with elevated lipoprotein(a). Nephrol Dial Transplant. 2008;23:1756-9 pubmed publisher
  31. Sanders P, Wang P. Activation of the Fas/Fas ligand pathway in hypertensive renal disease in Dahl/Rapp rats. BMC Nephrol. 2002;3:1 pubmed
    Hypertensive nephrosclerosis is the second most common cause of end-stage renal failure in the United States. The mechanism by which hypertension produces renal failure is incompletely understood...
  32. Fukuda M, Usami T, Kimura G. [Hypertensive nephrosclerosis]. Nihon Rinsho. 2004;62 Suppl 3:357-62 pubmed
  33. Hertig A, Anglicheau D, Verine J, Pallet N, Touzot M, Ancel P, et al. Early epithelial phenotypic changes predict graft fibrosis. J Am Soc Nephrol. 2008;19:1584-91 pubmed publisher
    ..In conclusion, early phenotypic changes indicative of epithelial-to-mesenchymal transition predict the progression toward interstitial fibrosis in human renal allografts...
  34. Bhalla M, Aziz H, Richard E, Lipkowitz M, Bhatnagar V. Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis. J Hum Hypertens. 2013;27:393-6 pubmed publisher
    ..N=828) is a subset of the AASK trial that randomized 1094 African American men and women with hypertensive nephrosclerosis to ramipril, amlodipine or metoprolol...
  35. Zhong X, Chung A, Chen H, Meng X, Lan H. Smad3-mediated upregulation of miR-21 promotes renal fibrosis. J Am Soc Nephrol. 2011;22:1668-81 pubmed publisher
    ..In conclusion, these data demonstrate that Smad3, but not Smad2, signaling increases expression of miR-21, which promotes renal fibrosis. Inhibition of miR-21 may be a therapeutic approach to suppress renal fibrosis...
  36. Wang H, Nishiya K, Ito H, Hosokawa T, Hashimoto K, Moriki T. Iron deposition in renal biopsy specimens from patients with kidney diseases. Am J Kidney Dis. 2001;38:1038-44 pubmed
    ..renal diseases, mainly consisting of 12 patients with immunoglobulin A nephropathy and 5 patients with benign nephrosclerosis. Mean arterial pressure (MAP), serum creatinine (sCr) levels, incidence of hematuria, and urinary N-..
  37. Paronetto F. IMMUNOCYTOCHEMICAL OBSERVATIONS ON THE VASCULAR NECROSIS AND RENAL GLOMERULAR LESIONS OF MALIGNANT NEPHROSCLEROSIS. Am J Pathol. 1965;46:901-15 pubmed
  38. Hirayama T, Takahashi F, Kikuchi K. [Secondary nephrotic syndrome due to cardiovascular disease]. Nihon Rinsho. 2004;62:1930-4 pubmed
    ..In eldery patients cardiovascular diseases are appeared. It is very important for clinicians to detect the mechanism of nephrotic syndrome caused by cardiovascular diseases...
  39. Beloborodova E, Zibnitskaia L, Kaliuzhina E. [The course of chronic glomerulonephritis in chronic opisthorchiasis]. Ter Arkh. 2005;77:44-9 pubmed
    ..To characterize clinical, functional and morphological features of chronic glomerulonephritis (CGN) running with chronic opisthorchiasis (CO) and to justify dehelminthization...
  40. Hellman R, Decker B, Murray M. Elevated serum creatinine and a normal urinalysis: a short differential diagnosis in the etiology of renal failure. Ren Fail. 2006;28:389-94 pubmed
    ..This study was designed to identify the specific disease states that encompass this interesting renal condition...
  41. de Francisco A, Izquierdo M, Cunningham J, Piñera C, Palomar R, Fresnedo G, et al. Calcium-mediated parathyroid hormone release changes in patients treated with the calcimimetic agent cinacalcet. Nephrol Dial Transplant. 2008;23:2895-901 pubmed publisher
    ..Calcimimetics allosterically modify CaR and render it more sensitive to extracellular Ca(2+), accounting for the simultaneous reduction of Ca(2+) and PTH seen in most patients...
  42. Abboud H, Labreuche J, Duyckaerts C, Hauw J, Amarenco P. Prevalence of nephroangiosclerosis in patients with fatal stroke. Neurology. 2009;72:899-904 pubmed publisher
    ..Glomerular filtration rate and decline in renal function can be improved by global cardiovascular prevention. However, the prevalence of nephroangiosclerosis in patients with stroke is unknown...
  43. Van Beneden K, van Grunsven L, Geers C, Pauwels M, Desmouliere A, Verbeelen D, et al. CRBP-I in the renal tubulointerstitial compartment of healthy rats and rats with renal fibrosis. Nephrol Dial Transplant. 2008;23:3464-71 pubmed publisher
    ..Here, we investigate the distribution of CRBP-I in the renal cortex of healthy rats and rats with renal fibrosis...
  44. Morita S, Fukuhara S, Akizawa T, Asano Y, Koshikawa S, Koide K, et al. Prognostic factors for a composite end-point of renal outcomes in patients with chronic kidney disease. Ther Apher Dial. 2006;10:72-7 pubmed
    ..20 years of age or older with chronic renal disease caused by diabetic nephropathy, glomerulonephritis, or nephrosclerosis, and who had baseline sCr levels of 5.0 mg/dL or less...
  45. Gainer J, Lipkowitz M, Yu C, Waterman M, Dawson E, Capdevila J, et al. Association of a CYP4A11 variant and blood pressure in black men. J Am Soc Nephrol. 2008;19:1606-12 pubmed publisher
    ..In summary, the CYP4A11 8590CC genotype is associated with increased BP in black men with hypertensive nephrosclerosis and is associated with adverse clinical outcomes in those with baseline proteinuria...
  46. Tanaka H, Tateyama T, Suzuki K, Nakahata T, Kudo M, Takahashi Y, et al. Acute renal failure due to hypertension: malignant hypertension in an adolescent. Pediatr Int. 2003;45:342-4 pubmed
  47. Scarpelli P, Gallo M, De Cesaris F, Chiari G, Dedola G, Cappeli S, et al. Continuing follow-up of malignant hypertension. J Nephrol. 2002;15:431-7 pubmed
    ..and unsolved problems related to the disease are illustrated, including its relationship to malignant nephrosclerosis, as well as terminology, current frequency and treatment...
  48. Bidani A, Griffin K, Williamson G, Wang X, Loutzenhiser R. Protective importance of the myogenic response in the renal circulation. Hypertension. 2009;54:393-8 pubmed publisher
  49. Chang Y, Lee S, Chung B, Kim Y, Shin Y. Renal histology in patients with elevated serum creatinine and concurrent normal urinalysis. Clin Nephrol. 2012;77:283-9 pubmed
    ..The purpose of the current study was to determine the histologic diagnosis of patients with elevated serum creatinine and a concurrent normal urinalysis without underlying disease...
  50. Malatino L, Stancanelli B, Giannakakis C, Marcantoni C. [Hypertensive nephrosclerosis: an exhaustive diagnosis?]. G Ital Nefrol. 2012;29:650-4 pubmed
    Hypertensive nephrosclerosis is a much overused clinical diagnosis, largely unsubstantiated by biopsy data. It is in fact a clinical-pathological diagnosis implying a causal role of hypertension in the associated chronic kidney disease...
  51. Zhou X, Fukuda N, Matsuda H, Endo M, Wang X, Saito K, et al. Complement 3 activates the renal renin-angiotensin system by induction of epithelial-to-mesenchymal transition of the nephrotubulus in mice. Am J Physiol Renal Physiol. 2013;305:F957-67 pubmed publisher
    ..Thus C3 induces EMT and dedifferentiation of epithelial cells, which produce renin through induction of LXR?. These data indicate for the first time that C3 may be a primary factor to activate the renal RA systems to induce hypertension...
  52. Obialo C, Hewan Lowe K. Rapid progression to end-stage renal disease in young hypertensive African Americans with proteinuria. J Natl Med Assoc. 1998;90:649-55 pubmed
    Hypertensive nephrosclerosis (HN) remains the most common cause of end-stage renal disease (ESRD) in blacks. This study examined whether renal histology corresponds with clinical hypertension in proteinuric blacks...
  53. Sanders L. Exercise-induced acute renal failure associated with ibuprofen, hydrochlorothiazide, and triamterene. J Am Soc Nephrol. 1995;5:2020-3 pubmed
    ..Renal biopsy showed acute tubular necrosis and arteriolar nephrosclerosis. Although exercise-associated acute renal failure is uncommon, susceptible patients with exercise-induced ..