interstitial nephritis

Summary

Summary: Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.

Top Publications

  1. Praga M, González E. Acute interstitial nephritis. Kidney Int. 2010;77:956-61 pubmed publisher
    Acute interstitial nephritis (AIN) represents a frequent cause of acute kidney injury, accounting for 15-27% of renal biopsies performed because of this condition...
  2. Perazella M, Markowitz G. Drug-induced acute interstitial nephritis. Nat Rev Nephrol. 2010;6:461-70 pubmed publisher
    Acute interstitial nephritis (AIN) is a common cause of acute kidney injury. Many etiologies of AIN have been recognized--including allergic/drug-induced, infectious, autoimmune/systemic, and idiopathic forms of disease...
  3. Jover Sáenz A, Porcel Pérez J, Madroñero Vuelta A, Bielsa Martín S. [Acute interstitial nephritis due to rifampicin]. Enferm Infecc Microbiol Clin. 2006;24:64 pubmed
  4. Vargas F, Gedalia A, Craver R, Matti Vehaskari V. Recurrence of granulomatous interstitial nephritis in transplanted kidney. Pediatr Transplant. 2010;14:e54-7 pubmed publisher
    ..The recurrent disease appeared to respond to increased immunosuppression, which included infliximab. However, the patient died of disseminated histoplasmosis three yr post-transplant...
  5. Esposito L, Kamar N, Guilbeau Frugier C, Mehrenberger M, Modesto A, Rostaing L. Linezolid-induced interstitial nephritis in a kidney-transplant patient. Clin Nephrol. 2007;68:327-9 pubmed
    ..The transplant kidney biopsy, performed 15 days after the beginning of linezolid therapy, showed interstitial nephritis and focal tubular atrophy...
  6. Sakairi T, Hiromura K, Yamashita S, Takeuchi S, Tomioka M, Ideura H, et al. Nestin expression in the kidney with an obstructed ureter. Kidney Int. 2007;72:307-18 pubmed
    ..Nestin expression was located in hypoxic regions of the kidney with an obstructed ureter. Our results indicate that nestin could be a novel marker for tubulointerstitial injury...
  7. Schmid S, Opravil M, Moddel M, Huber M, Pfammatter R, Keusch G, et al. Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies. Virchows Arch. 2007;450:665-70 pubmed
    ..All of them developed acute renal failure. The kidney biopsies of these patients showed an acute interstitial nephritis or a chronic interstitial nephritis with an acute component...
  8. Preddie D, Markowitz G, Radhakrishnan J, Nickolas T, D Agati V, Schwimmer J, et al. Mycophenolate mofetil for the treatment of interstitial nephritis. Clin J Am Soc Nephrol. 2006;1:718-22 pubmed
    Acute interstitial nephritis (AIN) is a clinicopathologic entity that is characterized by acute renal failure and renal biopsy findings of interstitial inflammation and tubulitis...
  9. Savard S, Desmeules S, Riopel J, Agharazii M. Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome. Am J Kidney Dis. 2009;54:e17-20 pubmed publisher
    ..Renal biopsy showed acute interstitial nephritis with eosinophilic cells...

More Information

Publications62

  1. Aoki A, Sato K, Itabashi M, Takei T, Yoshida T, Arai J, et al. A case of Mikulicz's disease complicated with severe interstitial nephritis associated with IgG4. Clin Exp Nephrol. 2009;13:367-372 pubmed publisher
    ..A diagnosis of Mikulicz's disease and interstitial nephritis was made, since biopsy specimens of her lacrimal gland and minor salivary gland showed diffuse ..
  2. Sierra F, Suarez M, Rey M, Vela M. Systematic review: Proton pump inhibitor-associated acute interstitial nephritis. Aliment Pharmacol Ther. 2007;26:545-53 pubmed
    A number of recent case reports and case series suggest that proton pump inhibitors may cause acute interstitial nephritis.
  3. Kamat A, Goldsmith D, O Donnell P, van der Walt J, Carr R. Renal failure with granulomatous interstitial nephritis and diffuse leukemic renal infiltration in chronic lymphocytic leukemia. Ren Fail. 2007;29:763-5 pubmed
    ..Granulomatous interstitial nephritis (GIN) is also rare, but a characteristic hallmark of certain diseases such as sarcoidosis and tuberculosis...
  4. Dixit M, Nguyen C, Carson T, Guedes B, Dixit N, Bell J, et al. Non-steroidal anti-inflammatory drugs-associated acute interstitial nephritis with granular tubular basement membrane deposits. Pediatr Nephrol. 2008;23:145-8 pubmed
    Acute tubulo-interstitial nephritis (ATIN) is an important cause of acute renal failure resulting from a variety of insults, including immune complex-mediated tubulo-interstitial injury, but drugs such as non-steroidal anti-inflammatory ..
  5. Bangs M, Sirait S, Purnomo -, Maguire J. Strongyloidiasis with gastric mucosal invasion presenting with acute interstitial nephritis. Southeast Asian J Trop Med Public Health. 2006;37:641-7 pubmed
    ..stercoralis filariform larvae and free-living adult worms, corroborating the diagnosis. The infection was associated with acute interstitial nephritis. The patient showed rapid and dramatic improvement after treatment with mebendazole.
  6. Shimoyama K, Ogawa N, Sawaki T, Karasawa H, Masaki Y, Kawabata H, et al. A case of Mikulicz's disease complicated with interstitial nephritis successfully treated by high-dose corticosteroid. Mod Rheumatol. 2006;16:176-82 pubmed
    ..A diagnosis of Mikulicz's disease and interstitial nephritis was made, since biopsy specimens of her lacrimal gland and minor salivary gland showed diffuse ..
  7. Sarli G, Mandrioli L, Panarese S, Brunetti B, Segales J, Dominguez J, et al. Characterization of interstitial nephritis in pigs with naturally occurring postweaning multisystemic wasting syndrome. Vet Pathol. 2008;45:12-8 pubmed publisher
    Kidney samples with interstitial nephritis from 26 pigs affected by postweaning multisystemic wasting syndrome (PMWS) were selected...
  8. Rheault M, Manivel J, Levine S, Sinaiko A. Sarcoidosis presenting with hearing loss and granulomatous interstitial nephritis in an adolescent. Pediatr Nephrol. 2006;21:1323-6 pubmed
    Granulomatous interstitial nephritis is an uncommon finding in a kidney biopsy. The differential diagnosis is broad and includes infections, drug exposure, and sarcoidosis...
  9. Baudeau C, Dard S, Zylberberg H, Patey Mariaud de Serre N. [Rabeprazole induced acute interstitial nephritis]. Rev Med Interne. 2008;29:834-6 pubmed publisher
    ..A 84-year-old women underwent renal biopsy because of rapidly progressive renal failure. Rabeprazole induced interstitial nephritis was diagnosed. Interstitial nephritis may complicate the course of any proton pump inhibitor treatment...
  10. Winn S, Ellis S, Savage P, Sampson S, Marsh J. Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?. Nephrol Dial Transplant. 2009;24:673-5 pubmed publisher
    ..We report the first biopsy confirmed occurrence of acute interstitial nephritis in a patient receiving treatment with Sunitinib for metastatic renal cell cancer...
  11. Rajakariar R, Sharples E, Raftery M, Sheaff M, Yaqoob M. Sarcoid tubulo-interstitial nephritis: long-term outcome and response to corticosteroid therapy. Kidney Int. 2006;70:165-9 pubmed
    ..Granulomatous tubulo-interstitial nephritis is an uncommon manifestation of this condition...
  12. Li J, Deane J, Campanale N, Bertram J, Ricardo S. The contribution of bone marrow-derived cells to the development of renal interstitial fibrosis. Stem Cells. 2007;25:697-706 pubmed
    ..Investigation of the signaling pathways that regulate the differentiation and survival of BM-derived cells in a progressive disease setting is vital for the successful development of cell-based therapies for renal repair...
  13. Colak N, Dede F, Canbakan B, Odabas A, Akyurek N. Acute tubulo-interstitial nephritis associated with mantle cell lymphoma presented as acute renal failure. Nephrology (Carlton). 2007;12:107-8 pubmed
  14. Kassiri Z, Oudit G, Kandalam V, Awad A, Wang X, Ziou X, et al. Loss of TIMP3 enhances interstitial nephritis and fibrosis. J Am Soc Nephrol. 2009;20:1223-35 pubmed publisher
    ..Taken together, these results provide evidence that TIMP3 is an important mediator of kidney injury, and regulating its activity may have therapeutic benefit for patients with kidney disease...
  15. Simpson I, Marshall M, Pilmore H, Manley P, Williams L, Thein H, et al. Proton pump inhibitors and acute interstitial nephritis: report and analysis of 15 cases. Nephrology (Carlton). 2006;11:381-5 pubmed
    ..The aim of the present study was to report and analyse the clinical features of 15 patients with acute interstitial nephritis (AIN) and acute renal failure from PPI that were referred to renal services in Auckland over a period of 3 ..
  16. Palmer D, Lallu S, Matheson P, Bethwaite P, Tompson K. Karyomegalic interstitial nephritis: a pitfall in urine cytology. Diagn Cytopathol. 2007;35:179-82 pubmed
    A case of a 44-yr-old Maori female presenting with chronic renal failure due to karyomegalic interstitial nephritis is reported. To our knowledge, this is the first instance this disorder has been reported in a New Zealand Maori...
  17. Halbritter J, Mayer C, Rasche F, Amann K, Lindner T. [Interstitial nephritis]. Internist (Berl). 2009;50:1111-25 pubmed publisher
    ..anti-inflammatory drugs and proton pump inhibitors, infections and systemic diseases can trigger interstitial nephritis. The clinical outcome varies from asymptomatic progression to acute kidney injury...
  18. Joss N, Morris S, Young B, Geddes C. Granulomatous interstitial nephritis. Clin J Am Soc Nephrol. 2007;2:222-30 pubmed
    Granulomatous interstitial nephritis (GIN) is a rare histologic diagnosis...
  19. Khurana A. Allergic interstitial nephritis possibly related to sunitinib use. Am J Geriatr Pharmacother. 2007;5:341-4 pubmed publisher
    ..Sunitinib is an oral multitargeted inhibitor indicated for the treatment of renal cell carcinoma...
  20. Gonzalez E, Gutierrez E, Galeano C, Chevia C, De Sequera P, Bernis C, et al. Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. Kidney Int. 2008;73:940-6 pubmed publisher
    The role of steroid treatment in drug-induced acute interstitial nephritis (DI-AIN) is controversial...
  21. López Gómez J, Rivera F. Renal biopsy findings in acute renal failure in the cohort of patients in the Spanish Registry of Glomerulonephritis. Clin J Am Soc Nephrol. 2008;3:674-81 pubmed publisher
    ..This study analyzed the frequency and clinicopathologic correlations of renal native biopsied acute renal failure in Spain during the period 1994 through 2006...
  22. Khaira A, Mendonca S. Steroids in acute interstitial nephritis. Kidney Int. 2008;74:971-2; author reply 972-3 pubmed publisher
  23. Parkhie S, Fine D, Lucas G, Atta M. Characteristics of patients with HIV and biopsy-proven acute interstitial nephritis. Clin J Am Soc Nephrol. 2010;5:798-804 pubmed publisher
    The objective of this study was to describe the characteristics of patients with HIV infection and biopsy-proven acute interstitial nephritis (AIN).
  24. Verine J, Reade R, Janin A, Droz D. [Karyomegalic interstitial nephritis: A new French case]. Ann Pathol. 2010;30:240-2 pubmed publisher
    Karyomegalic interstitial nephritis (KIN) is a rare and slowly progressive chronic interstitial nephritis (CIN) (28 cases reported), described for the first time by Mihatsch et al. in 1979...
  25. Geevasinga N, Coleman P, Webster A, Roger S. Proton pump inhibitors and acute interstitial nephritis. Clin Gastroenterol Hepatol. 2006;4:597-604 pubmed
    ..well-tolerated, there have been case reports and a recent case series implicating these drugs in acute interstitial nephritis (AIN) and progression to acute renal failure (ARF)...
  26. Spanou Z, Keller M, Britschgi M, Yawalkar N, Fehr T, Neuweiler J, et al. Involvement of drug-specific T cells in acute drug-induced interstitial nephritis. J Am Soc Nephrol. 2006;17:2919-27 pubmed
    Drug-induced interstitial nephritis can be caused by a plethora of drugs and is characterized by a sudden impairment of renal function, mild proteinuria, and sterile pyuria...
  27. Yang C, Lin C, Chang S, Hsu H. Rapidly progressive fibrosing interstitial nephritis associated with Chinese herbal drugs. Am J Kidney Dis. 2000;35:313-8 pubmed
    Rapidly progressive fibrosing interstitial nephritis after a slimming regimen containing aristolochic acid has been identified as Chinese herbs nephropathy (CHNP)...
  28. Hegarty J, Picton M, Agarwal G, Pramanik A, Kalra P. Carbamazepine-induced acute granulomatous interstitial nephritis. Clin Nephrol. 2002;57:310-3 pubmed
    ..Percutaneous renal biopsy revealed acute granulomatous interstitial nephritis, which responded successfully to high-dose oral steroid therapy.
  29. Kim M, Chang J, Lee S, Park J, Choi Y, Yang C, et al. Acute interstitial nephritis due to nicergoline (Sermion). Nephron. 2002;92:676-9 pubmed
    We report a case of acute interstitial nephritis (AIN) due to nicergoline (Sermion). A 50-year-old patient admitted to our hospital for fever and acute renal failure...
  30. Torpey N, Barker T, Ross C. Drug-induced tubulo-interstitial nephritis secondary to proton pump inhibitors: experience from a single UK renal unit. Nephrol Dial Transplant. 2004;19:1441-6 pubmed
    Acute tubulo-interstitial nephritis (TIN) is an important cause of acute renal failure, and is often caused by hypersensitivity to drugs...
  31. Tse K, Chan T, Wong S, Chan K, Lam M, Chan K, et al. Granulomatous interstitial nephritis of the allograft kidney associated with rhodococcal pulmonary infection. Nephrol Dial Transplant. 2004;19:486-90 pubmed
  32. Singh A, Colvin R. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 36-2003. A 68-year-old woman with impaired renal function. N Engl J Med. 2003;349:2055-63 pubmed
  33. Miyoshi K, Okura T, Manabe S, Watanabe S, Fukuoka T, Higaki J. Granulomatous interstitial nephritis due to isolated renal sarcoidosis. Clin Exp Nephrol. 2004;8:279-82 pubmed
    ..Finally, a diagnosis was made, of granulomatous interstitial nephritis due to isolated renal sarcoidosis...
  34. Brewster U, Perazella M. Acute interstitial nephritis associated with atazanavir, a new protease inhibitor. Am J Kidney Dis. 2004;44:e81-4 pubmed
    ..Renal biopsy showed acute interstitial nephritis. This is the first report of acute interstitial nephritis from atazanavir.
  35. Esteve J, Launay Vacher V, Brocheriou I, Grimaldi A, Izzedine H. COX-2 inhibitors and acute interstitial nephritis: case report and review of the literature. Clin Nephrol. 2005;63:385-9 pubmed
    We report a case of biopsy-proven acute interstitial nephritis (AIN) in a 50-year-old diabetic woman, who had been treated with celecoxib for 4 weeks before presentation...
  36. Thumfart J, Muller D, Rudolph B, Zimmering M, Querfeld U, Haffner D. Isolated sarcoid granulomatous interstitial nephritis responding to infliximab therapy. Am J Kidney Dis. 2005;45:411-4 pubmed
    ..renal impairment of sarcoidosis usually is caused by either hypercalcemia leading to nephrocalcinosis or interstitial nephritis with or without granulomata...
  37. Bijol V, Mendez G, Nose V, Rennke H. Granulomatous interstitial nephritis: a clinicopathologic study of 46 cases from a single institution. Int J Surg Pathol. 2006;14:57-63 pubmed
    Acute interstitial nephritis is commonly seen in kidney biopsies of patients with acute renal failure; however, granulomatous interstitial nephritis (GIN) is rare...
  38. Estebanez C, Fernandez Reyes M, Sánchez Hernández R, Mon C, Rodriguez F, Alvarez Ude F, et al. [Acute interstitial nephritis caused by clozapine]. Nefrologia. 2002;22:277-81 pubmed
    We are reporting a case of a 69 years old man developed acute renal failure due to interstitial nephritis during treatment with the drug clozapine, and that improve after to discontinuation of this drug...
  39. Dishon A, Perelberg A, Bishara Shieban J, Ilouze M, Davidovich M, Werker S, et al. Detection of carp interstitial nephritis and gill necrosis virus in fish droppings. Appl Environ Microbiol. 2005;71:7285-91 pubmed
    Carp interstitial nephritis and gill necrosis virus (CNGV) is an unclassified large DNA virus that morphologically resembles members of the Herpesviridae but contains a large (ca. approximately 280-kbp) linear double-stranded DNA...
  40. Ramalakshmi S, Bastacky S, Johnson J. Levofloxacin-induced granulomatous interstitial nephritis. Am J Kidney Dis. 2003;41:E7 pubmed
    ..Liver biopsy results showed nonspecific changes. Renal biopsy disclosed extensive granulomatous interstitial nephritis with associated granulomatous vasculitis...
  41. Chao Y, Yang A, Ng Y, Yang W. Acute interstitial nephritis and pigmented tubulopathy in a patient after wasp stings. Am J Kidney Dis. 2004;43:e15-9 pubmed
    ..wasp stings, to facilitate early steroid treatment for the patient with the histological change of acute interstitial nephritis. Early use of steroid therapy may hasten renal recovery by preventing the development of interstitial ..
  42. Pikarsky E, Ronen A, Abramowitz J, Levavi Sivan B, Hutoran M, Shapira Y, et al. Pathogenesis of acute viral disease induced in fish by carp interstitial nephritis and gill necrosis virus. J Virol. 2004;78:9544-51 pubmed
    ..however, it has characteristics inconsistent with the herpesvirus family, and thus we have called it carp interstitial nephritis and gill necrosis virus...
  43. Suh K, Kim S, Bang B, Yang C, Lee J, Park J, et al. BK polyomavirus interstitial nephritis in a renal allograft recipient. Ultrastruct Pathol. 2003;27:61-4 pubmed
    Human polyomavirus (PV) interstitial nephritis has recently been recognized as a cause of severe renal allograft dysfunction...
  44. Vanegas V, Ferrebuz A, Quiroz Y, Rodriguez Iturbe B. Hypertension in Page (cellophane-wrapped) kidney is due to interstitial nephritis. Kidney Int. 2005;68:1161-70 pubmed
    ..We investigated if interstitial nephritis, rather than plasma angiotensin activity, played a role in the development of hypertension in the Page ..
  45. Verma N, Arunabh S, Brady T, Charytan C. Acute interstitial nephritis secondary to infectious mononucleosis. Clin Nephrol. 2002;58:151-4 pubmed
    ..The purpose of this case report is to document a case of acute interstitial nephritis (AIN) leading to acute renal failure (ARF) in a patient with Epstein-Barr virus (EBV) infection and to ..
  46. Vaboe A, Leh S, Forslund T. Interstitial nephritis, acute renal failure in a patient with non-fulminant hepatitis A infection. Clin Nephrol. 2002;57:149-53 pubmed
    This is the first report from Norway of a patient with interstitial nephritis and renal failure due to non-fulminant hepatitis A virus (HAV) infection. HAV infection was confirmed by positive anti-HAV IgM serology...
  47. Baksh F, Finkelstein S, Swalsky P, Stoner G, Ryschkewitsch C, Randhawa P. Molecular genotyping of BK and JC viruses in human polyomavirus-associated interstitial nephritis after renal transplantation. Am J Kidney Dis. 2001;38:354-65 pubmed
    ..human polyomaviruses BK virus (BKV) and JC virus (JCV) have been linked to ureteric stenosis and allograft interstitial nephritis, but molecular characterization of the species involved has not been performed...
  48. Yokobori S, Yokota H, Yamamoto Y. Pediatric posterior reversible leukoencephalopathy syndrome and NSAID-induced acute tubular interstitial nephritis. Pediatr Neurol. 2006;34:245-7 pubmed
    ..One should consider reversible posterior leukoencephalopathy syndrome as a side effect of nonsteroidal anti-inflammatory drug use in daily medical treatment...
  49. Robson M, Banerjee D, Hopster D, Cairns H. Seven cases of granulomatous interstitial nephritis in the absence of extrarenal sarcoid. Nephrol Dial Transplant. 2003;18:280-4 pubmed
    Renal disease in sarcoidosis may occur due to granulomatous interstitial nephritis. However, granulomatous interstitial nephritis in the absence of features of extrarenal sarcoid, or other causes, has been reported very rarely...
  50. Kallel H, Hamida C, Ksibi H, Bahloul M, Hergafi L, Chaari A, et al. Suspected acute interstitial nephritis induced by colistin. J Nephrol. 2005;18:323-6 pubmed
    ..In addition, the time course of events suggested that colistin was the cause of acute interstitial nephritis in this patient...
  51. Gundappa R, Sud K, Kohli H, Jha V, Gupta K, Joshi K, et al. Snakebite induced acute interstitial nephritis: report of a rare entity. Ren Fail. 2002;24:369-72 pubmed
    ..Only 3 cases of acute interstitial nephritis in patients with snakebite induced acute renal failure have been previously reported...
  52. O Riordan E, Willert R, Reeve R, Kalra P, O Donoghue D, Foley R, et al. Isolated sarcoid granulomatous interstitial nephritis: review of five cases at one center. Clin Nephrol. 2001;55:297-302 pubmed
    To identify any clinical or biochemical parameters which determine prognostic outcome in isolated sarcoid granulomatous interstitial nephritis presenting with renal failure.
  53. Neilson E, McCafferty E, Feldman A, Clayman M, Zakheim B, Korngold R. Spontaneous interstitial nephritis in kdkd mice. I. An experimental model of autoimmune renal disease. J Immunol. 1984;133:2560-5 pubmed
    ..With these new findings we now hypothesize that susceptibility to the expression of interstitial nephritis in kdkd mice involves the cellular limb of the immune system, and may be related, in part, to alterations ..