kidney papillary necrosis

Summary

Summary: A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.

Top Publications

  1. Wu V, Fang C, Li W, Hsueh P, Chu T. Candida tropicalis-associated bilateral renal papillary necrosis and emphysematous pyelonephritis. Clin Nephrol. 2004;62:473-5 pubmed
    ..He was treated successfully with antifungal therapy and percutaneous nephrostomy (PCN). This is the first case report of C. tropicalis-associated EPN and RPN...
  2. Gordon M, Cervellione R, Postlethwaite R, Shabani A, Hennayake S. Acute renal papillary necrosis with complete bilateral ureteral obstruction in a child. Urology. 2007;69:575.e11-2 pubmed
    ..Although rare, recognition of sloughed papilla in papillary necrosis causing ureteral obstruction can lead to early management with no long-term sequelae...
  3. Sean T, Sheshadri S, Saravu K. Emphysematous pyelonephritis. J Assoc Physicians India. 2002;50:1413-5 pubmed
    ..It is almost always seen in diabetics, making it a concern of the physician. A high index of suspicion is required for diagnosis and a combined approach has significantly reduced the mortality...
  4. Vijayaraghavan S, Kandasamy S, Mylsamy A, Prabhakar M. Sonographic features of necrosed renal papillae causing hydronephrosis. J Ultrasound Med. 2003;22:951-6; quiz 957-8 pubmed
    ..To describe the sonographic appearance of ureteric obstruction due to necrosed papillae...
  5. De Broe M, Elseviers M. Over-the-counter analgesic use. J Am Soc Nephrol. 2009;20:2098-103 pubmed publisher
    ..As long as high-risk analgesic mixtures are available over the counter, analgesic nephropathy will continue to be a problem...
  6. Bach P, Nguyen T. Renal papillary necrosis--40 years on. Toxicol Pathol. 1998;26:73-91 pubmed
    ..There is still a need to understand better the primary mechanism and the secondary consequences of RPN so that the risk of chemical agents in use and novel molecules can be fully assessed...
  7. McCredie M, Stewart J. Does paracetamol cause urothelial cancer or renal papillary necrosis?. Nephron. 1988;49:296-300 pubmed
    ..By contrast, we were unable to substantiate an increased risk from paracetamol consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with cancer of the ureter...
  8. Groop L, Laasonen L, Edgren J. Renal papillary necrosis in patients with IDDM. Diabetes Care. 1989;12:198-202 pubmed
    ..It is concluded that RPN is a more frequent complication of long-standing IDDM than appreciated from autopsy studies, and being female and having a history of urinary tract infection are associated with an increased risk of RPN...
  9. Akhund L, Quinet R, Ishaq S. Celecoxib-related renal papillary necrosis. Arch Intern Med. 2003;163:114-5 pubmed
    ..This case report posits celecoxib as a likely cause of renal papillary necrosis and alerts physicians to the possibility of this additional renal complication with COX-2-specific inhibitors...

More Information

Publications62

  1. Tsuchiya Y, Takahashi Y, Jindo T, Furuhama K, Suzuki K. Comprehensive evaluation of canine renal papillary necrosis induced by nefiracetam, a neurotransmission enhancer. Eur J Pharmacol. 2003;475:119-28 pubmed
  2. Atta M, Whelton A. Acute renal papillary necrosis induced by ibuprofen. Am J Ther. 1997;4:55-60 pubmed
    ..This is especially important considering the recent FDA approval of the over-the-counter sale of naproxen sodium, ketoprofen, and ibuprofen...
  3. Nanra R. Pattern of renal dysfunction in analgesic nephropathy--comparison with glomerulonephritis. Nephrol Dial Transplant. 1992;7:384-90 pubmed
    ..These function defects are consistent with the primary lesion of renal papillary necrosis in analgesic nephropathy; the detection of these defects have implications in patient management...
  4. Lenz S. Investigation of regional glutathione levels in a model of chemically-induced renal papillary necrosis. Food Chem Toxicol. 1996;34:489-94 pubmed
    ..The findings indicate that diphenylamine-induced renal papillary necrosis in the Syrian hamster is not associated with a decrease in renal papillary or outer medullary GSH nor mediated by oxidative cell injury...
  5. Knopf H, Schulze H. [Nephrectomy in acute uncomplicated pyelonephritis]. Urologe A. 2004;43:1416-9 pubmed
    ..Which complications can develop from uncomplicated pyelonephritis that may require nephrectomy?..
  6. Johansson S, Anderström C. The influence of antipyrene on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced urinary tract carcinogenesis. Carcinogenesis. 1988;9:783-7 pubmed
    ..The present study clearly shows that antipyrene acts as a promoter of FANFT-induced urinary tract carcinogenesis and that it is nephrotoxic to the renal papilla resulting in renal papillary necrosis...
  7. Henrich W. Analgesic nephropathy. Am J Med Sci. 1988;295:561-8 pubmed
    ..This review discusses both of these disorders from a clinical perspective...
  8. Mokrzycki M, Yamase H, Kohn O. Renal malacoplakia with papillary necrosis and renal failure. Am J Kidney Dis. 1992;19:587-91 pubmed
    ..The patient, who initially required dialysis, partially recovered renal function following prolonged antibiotic treatment with a fluoroquinolone antibiotic...
  9. Ahmed S, Ibrahim U. Haemoglobin-S in sickle cell trait with papillary necrosis. Br J Haematol. 2006;135:415-6 pubmed
  10. Jung D, Kim S, Jung S, Hwang S, Kim S. Renal papillary necrosis: review and comparison of findings at multi-detector row CT and intravenous urography. Radiographics. 2006;26:1827-36 pubmed
    ..Familiarity with the CT features of the condition therefore is useful for its successful diagnosis and management...
  11. Labidi J, Battikh R, Abdelhafidh N, Jeribi A, M sadek F, Louzir B, et al. [Candida albicans urinary tract infection complicated by renal papillary necrosis and fungus balls]. Med Mal Infect. 2008;38:330-1 pubmed publisher
  12. Lenz S, Carlton W. Decreased incidence of diphenylamine-induced renal papillary necrosis in Syrian hamsters given dimethylsulphoxide. Food Chem Toxicol. 1991;29:409-18 pubmed
    ..Renal papillary necrosis was not observed in any of the Mongolian gerbils. The results of these studies suggest that DMSO protects against diphenylamine-induced renal papillary necrosis in male Syrian hamsters...
  13. Mihatsch M, Khanlari B, Brunner F. Obituary to analgesic nephropathy--an autopsy study. Nephrol Dial Transplant. 2006;21:3139-45 pubmed
  14. Gebreselassie S, Simmons M, Montague D. Genitourinary manifestations of sickle cell disease. Cleve Clin J Med. 2015;82:679-83 pubmed publisher
    ..Our review of the genitourinary manifestations of sickle cell disease focuses on sickle cell nephropathy, priapism, and other genitourinary complications such as papillary necrosis and renal medullary carcinoma. ..
  15. Okamura T, Garland E, Taylor R, Johansson S, Cohen S. The effect of cyclophosphamide administration on the kidney of the rat. Toxicol Lett. 1992;63:261-76 pubmed
    ..It appears that the presence of vesico-ureteral reflux with or without associated hydroureter and hydronephrosis is a prerequisite for cyclophosphamide-induced renal damage...
  16. Elseviers M, De Broe M. Analgesic nephropathy: is it caused by multi-analgesic abuse or single substance use?. Drug Saf. 1999;20:15-24 pubmed
    ..Effective prevention of analgesic nephropathy consists of the prohibition of over-the-counter sales of preparation containing at least 2 analgesics associated with caffeine and/or codeine...
  17. Rebibou J, Kiesterman J, Cercueil J, Tanter Y, Portier H, Rifle G, et al. Papillary necrosis: a late complication of nephropathia epidemica?. Clin Nephrol. 1997;48:263-5 pubmed
    ..If arterial hypertension has already been reported as a complication of nephropathia epidemica, papillary necrosis is exceptional, but may be explained by the severe vascular troubles engendered by Hantavirus infection in kidney medulla...
  18. Zadeii G, Lohr J. Renal papillary necrosis in a patient with sickle cell trait. J Am Soc Nephrol. 1997;8:1034-9 pubmed
    ..The pathophysiology of renal abnormalities associated with sickle cell trait is described. The management of the primary clinical manifestations of this disorder, hematuria and papillary necrosis, are discussed...
  19. Thielemann L, Oberhauser E, Rosenblut G, Videla L, Valenzuela A. Sulfur-containing amino acids that increase renal glutathione protect the kidney against papillary necrosis induced by 2-bromoethylamine. Cell Biochem Funct. 1990;8:19-24 pubmed
    ..It is suggested that the observed protective effects against BEA-induced renal papillary injury may be ascribed in some measure, to a mechanism independent of GSH...
  20. Bahloul A, Jemel S, Koubaa A, Letaief Y, Mhiri M. [Emphysematous pyelonephritis. Apropos of 4 cases]. Prog Urol. 1993;3:803-11 pubmed
    ..The prognosis remains severe, with a high mortality; 2 of our patients died in a context of severe septic shock with end-stage renal failure...
  21. Desport E, Bridoux F, Ayache R, Thierry A, Belmouaz S, Irani J, et al. Papillary necrosis following segmental renal infarction: an unusual cause of early renal allograft dysfunction. Nephrol Dial Transplant. 2005;20:830-3 pubmed
  22. Melzi M, Guez S, Sersale G, Terzi F, Secco E, Marra G, et al. Acute pyelonephritis as a cause of hyponatremia/hyperkalemia in young infants with urinary tract malformations. Pediatr Infect Dis J. 1995;14:56-9 pubmed
  23. Griffin M, Bergstralhn E, Larson T. Renal papillary necrosis--a sixteen-year clinical experience. J Am Soc Nephrol. 1995;6:248-56 pubmed
    ..The overall risk for requiring renal replacement therapy after the diagnosis of renal papillary necrosis in surviving patients was low (7% of 136 patients at risk).(ABSTRACT TRUNCATED AT 250 WORDS)..
  24. Rosenberg M, Hostetter T. Comparison of residual glomerular function in experimental papillary necrosis and renal infarction. Am J Kidney Dis. 1990;16:118-25 pubmed
    ..Based on the differences in the two models, the site of the increased proteinuria in the remnant group could be the deep nephrons and/or the nephrons adjacent to the scar...
  25. Hasegawa R, Takahashi M, Furukawa F, Toyoda K, Sato H, Hayashi Y. Co-carcinogenic effect of retinyl acetate on forestomach carcinogenesis of male F344 rats induced with butylated hydroxyanisole. Jpn J Cancer Res. 1988;79:320-8 pubmed
    ..25% RA and in one rat (10%) with 0.05% RA co-administration. RA alone did not induce hyperplastic changes in the forestomach. These findings indicate that RA acted as a co-carcinogen in the BHA forestomach carcinogenesis of the rat...
  26. Atasever T, Ozkaya O, Abamor E, Soylemezoglu O, Buyan N, Unlu M. 99mTc ethylene dicysteine scintigraphy for diagnosing cortical defects in acute pyelonephritis: a comparative study with 99mTc dimercaptosuccinic acid. Nucl Med Commun. 2004;25:967-70 pubmed
  27. Carrie A, Metge C, Collins D, Harding G, Zhanel G. Use of administrative healthcare claims to examine the effectiveness of trimethoprim-sulfamethoxazole versus fluoroquinolones in the treatment of community-acquired acute pyelonephritis in women. J Antimicrob Chemother. 2004;53:512-7 pubmed
    ..To evaluate the effectiveness of trimethoprim-sulfamethoxazole and fluoroquinolones in the treatment of community-acquired acute pyelonephritis...
  28. Harandou M, Khatouf M, Bouhafa T, Kanjaa N, Leclercq G, Lapostolle F. [Emphysematous pyelonephritis with favourable outcome after conservative treatment]. Ann Fr Anesth Reanim. 2005;24:556-8 pubmed
    ..We report the case of a woman, unknown diabetic, who presented with emphysematous pyelonephritis. Early diagnosis performed by CT-scan allowed effective and conservative surgical treatment and final positive outcome...
  29. Cline K, Lang E. Renal gastric fistula caused by staghorn calculus. J Urol. 2005;174:1107 pubmed
  30. Khan K, Alden C, Gleissner S, Gessford M, Maziasz T. Effect of papillotoxic agents on expression of cyclooxygenase isoforms in the rat kidney. Toxicol Pathol. 1998;26:137-42 pubmed
    ..This decrease in COX isoforms in the renal papilla may contribute to the development of RPN through the loss of vasodilatory PGs...
  31. Gonzalez J, Marcol B, Wolf M. Complications of intravesical bacillus Calmette-Guerin: a case report. J Urol. 1992;148:1892-3 pubmed
    ..Although severe, this complication is rare and we conclude that reflux is not a contraindication for intravesical BCG therapy...
  32. Hui A, Wong S. Deafness and liver disease in a 57-year-old man: a medical history of Beethoven. Hong Kong Med J. 2000;6:433-8 pubmed
    ..In the absence of further histological examination, there is no definitive answer to the cause of his deafness and gastro-intestinal symptoms...
  33. Abe K, Ozono Y, Miyazaki M, Furusu A, Shioshita K, Sasaki O, et al. Prostaglandin E1 for renal papillary necrosis in a patient with diabetes mellitus. J Int Med Res. 1999;27:90-5 pubmed
    ..The administration of prostaglandin E1 produced an improvement in renal haemodynamics and can be considered as a possible therapy for renal papillary necrosis in diabetic patients...
  34. Thielemann L, Rodrigo R, Videla L. Changes in antioxidant enzyme activities and lipid peroxidation related to bromoethylamine-induced renal cytotoxicity. Arch Med Res. 1999;30:14-8 pubmed
    ..The effect of bromoethylamine (BEA) administration on lipid peroxidation and on the activities of antioxidant enzymes was studied...
  35. Garber S, Mirochnik Y, Desai S, Arruda J, Dunea G. Angiotensin-converting enzyme inhibition reduces the effect of bromoethylamine-induced papillary necrosis and renal fibrosis. J Am Soc Nephrol. 1998;9:1052-9 pubmed
    ..It is concluded that in this model of papillary necrosis, enalapril protects renal function and decreases interstitial fibrosis mediated at least in part through an angiotensin II/bradykinin-dependent mechanism...
  36. Hard G, Neal G. Sequential study of the chronic nephrotoxicity induced by dietary administration of ethoxyquin in Fischer 344 rats. Fundam Appl Toxicol. 1992;18:278-87 pubmed
    ..Contrary to a previous report, there was no evidence that ethoxyquin directly induced preneoplastic renal tubule hyperplasia...
  37. Carlton W, Engelhardt J. Experimental renal papillary necrosis in the Syrian hamster. Food Chem Toxicol. 1989;27:331-40 pubmed
    ..Only a few of the hamsters given indomethacin had renal papillary lesions and none of those given acetaminophen (up to 400 mg/kg) or phenylbutazone (up to 600 mg/kg) developed renal papillary lesions...
  38. Brix A. Renal papillary necrosis. Toxicol Pathol. 2002;30:672-4 pubmed
  39. Lenz S, Carlton W. Diphenylamine-induced renal papillary necrosis and necrosis of the pars recta in laboratory rodents. Vet Pathol. 1990;27:171-8 pubmed
    ..Renal papillary necrosis in the Syrian hamster treated orally with diphenylamine is reproducible, is of short onset, and is induced in a high proportion of the hamsters (70-90%).(ABSTRACT TRUNCATED AT 250 WORDS)..
  40. Gregg N, Elseviers M, De Broe M, Bach P. Epidemiology and mechanistic basis of analgesic-associated nephropathy. Toxicol Lett. 1989;46:141-51 pubmed
    ..Additional animal experiments are needed in order to clarify the molecular pathogenesis of RPN and UUC, to differentiate the stages in progression to ESRF and to develop more sensitive and selective diagnostic criteria...
  41. Alhwiesh A. An update on sickle cell nephropathy. Saudi J Kidney Dis Transpl. 2014;25:249-65 pubmed
    ..Whether bone marrow transplantation in the early stage of the disease can halt the progression of SCN is unknown and awaits clinical studies. ..
  42. Gabrovsky A, Aderinto A, Aderinto A, Spevak M, Vichinsky E, Resar L. Low dose, oral epsilon aminocaproic acid for renal papillary necrosis and massive hemorrhage in hemoglobin SC disease. Pediatr Blood Cancer. 2010;54:148-50 pubmed publisher
    ..Although further study is warranted, this case illustrates the need to consider EACA in the conservative management of renal papillary necrosis and significant hemorrhage in sickle cell hemoglobinopathies...
  43. Burrell J, Yong J, Macdonald G. Analgesic nephropathy in Fischer 344 rats: comparative effects of chronic treatment with either aspirin or paracetamol. Pathology. 1991;23:107-14 pubmed
    ..These structural changes were similar to those described previously, when continuous treatment with combined aspirin and paracetamol was studied in the same animal model...
  44. Burrell J, Yong J, Macdonald G. Irreversible damage to the medullary interstitium in experimental analgesic nephropathy in F344 rats. J Pathol. 1991;164:329-38 pubmed
    ..The associated urinary concentrating defect is reversible only during the early stages of structural damage to the inner medulla...
  45. Nair S, George C, Byass O. Medical image. Bilateral loin pain. N Z Med J. 2006;119:U2258 pubmed
  46. Segasothy M, Kamal A, Das D, Naidu R, Sivalingam S. Renal papillary necrosis in the east coast of Peninsular Malaysia. Singapore Med J. 1990;31:250-2 pubmed
    ..It was found that 1.3% of IVUs had RPN. There was a higher incidence of RPN amongst males as compared to females. RPN occurred more commonly in the younger age groups...
  47. Henry M, Tange J. Spontaneous papillary necrosis in the heterozygous Gunn rat. Pathology. 1989;21:288-93 pubmed
    ..Similar papillary changes were not found in albino or homozygous Gunn rats, but in aging albino rats there was loss of papillary interstitial cells without accumulation of amorphous material...
  48. Tsuchiya Y, Yabe K, Takada S, Ishii Y, Jindo T, Furuhama K, et al. Early pathophysiological features in canine renal papillary necrosis induced by nefiracetam. Toxicol Pathol. 2005;33:561-9 pubmed
    ..These results demonstrate that the epithelial cell in the papillary ducts is the primary target site for the onset of RPN evoked by nefiracetam...
  49. Ataiipour Y, Laville M, Combarnous F, David L, Zech P. Papillary necrosis and medullary sponge kidney in a patient with hemoglobin SC. Am J Nephrol. 1994;14:213-5 pubmed
    ..Medullary sponge kidney was also discovered by radiologic investigations. Papillary cysts could play a role in the occurrence of papillary necrosis...
  50. Kolaja G, Packwood W, Bell R, Ratke C, Stout C. Renal papillary necrosis and urinary protein alterations induced in Fischer-344 rats by D-ormaplatin. Toxicol Pathol. 1994;22:29-38 pubmed
    ..SDS-PAGE provided a useful method for detecting and localizing renal toxicity when used in conjunction with morphologic and clinical chemistry methods...
  51. Maiza A, Daley Yates P. Variability in the renal clearance of cephalexin in experimental renal failure. J Pharmacokinet Biopharm. 1993;21:19-30 pubmed
    ..In this respect the GFR alone was not an adequate parameter for the prediction of the renal clearance of such drugs...
  52. Negri S, Formentini G, Aletto A, Azzolini D. [Intravascular malignant lymphoma: report of a case]. Pathologica. 1997;89:527-30 pubmed
    ..A bilateral papillar renal necrosis was detected. This necrosis, not mentioned by the preceding literature, was, in all probability, caused by alterations of the microcirculation...
  53. Whelton A. Renal and related cardiovascular effects of conventional and COX-2-specific NSAIDs and non-NSAID analgesics. Am J Ther. 2000;7:63-74 pubmed
    ..It is important that healthcare providers and practitioners are aware of the relative renal risks of different analgesics and that they use this knowledge to counsel the analgesic-consuming population appropriately...