kidney cortex necrosis

Summary

Summary: Death of cells in the KIDNEY CORTEX, a common final result of various renal injuries including HYPOXIA; ISCHEMIA; and drug toxicity.

Top Publications

  1. Balseiro A, Dalton K, del Cerro A, Marquez I, Parra F, Prieto J, et al. Outbreak of common midwife toad virus in alpine newts (Mesotriton alpestris cyreni) and common midwife toads (Alytes obstetricans) in northern Spain: a comparative pathological study of an emerging ranavirus. Vet J. 2010;186:256-8 pubmed publisher
    ..This is the first report of ranavirus infection in the alpine newt, the second known species to be affected by CMTV in the past 2 years...
  2. Berlanga J, Calahorra J, Caramelo C. [Acute kidney failure with the absence of renal blood flow during an obstetric catastrophe: renal vasospasm versus cortical necrosis]. Nefrologia. 2004;24:194-5 pubmed
  3. Ponnusamy M, Liu N, Gong R, Yan H, Zhuang S. ERK pathway mediates P2X7 expression and cell death in renal interstitial fibroblasts exposed to necrotic renal epithelial cells. Am J Physiol Renal Physiol. 2011;301:F650-9 pubmed publisher
    ..Taken together, these data reveal that necrotic RPTC induces P2X7 expression in renal fibroblasts through activation of the MEK1-ERK1/2-Elk1 signaling pathway...
  4. Jha V, Sakhuja V. Postpartum renal cortical necrosis. Nephrol Dial Transplant. 2005;20:1010 pubmed
  5. Toh H, Cheng K, Kuar W, Tan C. The Case. Generalized petechiae and acute renal failure: bilateral renal cortical necrosis in meningococcemia. Kidney Int. 2008;73:1443-4 pubmed publisher
  6. Marrón B, Ortiz A, de Sequera P, Martín Reyes G, de Arriba G, Lamas J, et al. Impact of end-stage renal disease care in planned dialysis start and type of renal replacement therapy--a Spanish multicentre experience. Nephrol Dial Transplant. 2006;21 Suppl 2:ii51-5 pubmed
    ..The purpose of this study is to analyse the effect of chronic renal disease care and education on the mode of dialysis start (planned vs non-planned) and on the modality of renal replacement therapy (RRT)...
  7. Prakash J, Kumar H, Sinha D, Kedalaya P, Pandey L, Srivastava P, et al. Acute renal failure in pregnancy in a developing country: twenty years of experience. Ren Fail. 2006;28:309-13 pubmed
    ..The incidence of cortical necrosis decreased significantly (p < 0.001) from 17% in 1982-1991 to 2.4% in the 2000s. The maternal mortality reduced to 6.4% in 1992-2002 from initial high mortality of 20% in the period of 1982-1991...
  8. Matos R, Vieira C, Morais S, Pereira M, Pedrosa J. Nephrotoxicity effects of the wood preservative chromium copper arsenate on mice: histopathological and quantitative approaches. J Trace Elem Med Biol. 2009;23:224-30 pubmed publisher
    ..The nephrotoxicity of CCA was higher than its components per se, evidencing a possible synergetic effect...
  9. Blondin D, Hetzel G, Jung G. [Angiographic picture of severe acute renal microangiopathy]. Rofo. 2006;178:337-9 pubmed

More Information

Publications62

  1. Domanski L, Sulikowski T, Safranow K, Pawlik A, Olszewska M, Chlubek D, et al. Effect of trimetazidine on the nucleotide profile in rat kidney with ischemia-reperfusion injury. Eur J Pharm Sci. 2006;27:320-7 pubmed
    ..Moreover, significantly less pronounced acute tubular necrosis was observed in kidneys of rats treated with TMZ. These results suggest that trimetazidine protects against dephosphorylation of nucleotides and ischemic damage...
  2. Damianovich M, Ziv I, Heyman S, Rosen S, Shina A, Kidron D, et al. ApoSense: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis. Eur J Nucl Med Mol Imaging. 2006;33:281-91 pubmed
    ..The purpose of this study was to test the applicability of these molecules as a diagnostic imaging agent for the detection of renal tubular cell injury following renal ischemia...
  3. Marin E, Moeckel G, Al Lamki R, Bradley J, Yan Q, Wang T, et al. Identification and regulation of reticulon 4B (Nogo-B) in renal tubular epithelial cells. Am J Pathol. 2010;177:2765-73 pubmed publisher
    ..Furthermore, Nogo-B may regulate macrophage recruitment after UUO, although it does not greatly affect the degree of tissue injury or fibrosis in this model...
  4. Shah P, Falodia J, Kute V, Kanodia K, Vanikar A, Goplani K, et al. Acute renal failure in the pediatric age group - single center prospective study of 180 cases. Saudi J Kidney Dis Transpl. 2011;22:1072-6 pubmed
    ..Delayed referral, malnutrition, infections, age less than one year and multiorgan involvement were bad prognostic features...
  5. Ozaki K, Miyayama S, Ushiogi Y, Matsui O. Renal involvement of polyarteritis nodosa: CT and MR findings. Abdom Imaging. 2009;34:265-70 pubmed publisher
    ..To evaluate the imaging findings in patients with renal involvement of Polyarteritis nodosa (PN) to diagnose as early as possible...
  6. Miljkovic A, Pfohl Leszkowicz A, Dobrota M, Mantle P. Comparative responses to mode of oral administration and dose of ochratoxin A or nephrotoxic extract of Penicillium polonicum in rats. Exp Toxicol Pathol. 2003;54:305-12 pubmed
    ..The study demonstrates the potential for exaggerated toxicological responses to ochratoxin A administered by gavage through predicted consequential surges in the circulating concentration of the mycotoxin...
  7. Ura H, Asai Y, Mori K, Nara S, Yoshida M, Itoh Y. Total necrosis of the pancreas and renal cortex secondary to hypothermia therapy. J Trauma. 2002;52:987-9 pubmed
  8. Nakhla J, De la Garza Ramos R, Bhashyam N, Kobets A, Nasser R, Echt M, et al. The Impact of Kidney Disease on Acute Tubular Necrosis and Surgical Site Infection After Lumbar Fusion. World Neurosurg. 2017;105:498-502 pubmed publisher
    ..The rate of ATN significantly increases based on severity of kidney disease. However, patients with transplants have ATN and SSI rates comparable with patients without kidney disease. ..
  9. Haase M, Haase Fielitz A, Bagshaw S, Ronco C, Bellomo R. Cardiopulmonary bypass-associated acute kidney injury: a pigment nephropathy?. Contrib Nephrol. 2007;156:340-53 pubmed
    ..A trial of such treatment might be a reasonable future investigation in higher risk patients receiving CPB...
  10. Murai T, Iwata H, Otoshi T, Endo G, Horiguchi S, Fukushima S. Renal lesions induced in F344/DuCrj rats by 4-weeks oral administration of dimethylarsinic acid. Toxicol Lett. 1993;66:53-61 pubmed
    ..The results thus show that DMA is nephrotoxic to both male and female rats...
  11. Sastre López A, Gago González E, Baños Gallardo M, Gomez Huertas E, Ortega Suárez F. [All-trans retinoic acid syndrome [corrected] and renal cortical necrosis]. An Med Interna. 2007;24:551-3 pubmed
    ..Treatment is based on ATRA suspension, steroids and support measures...
  12. Khalil P, Murty P, Palevsky P. The patient with acute kidney injury. Prim Care. 2008;35:239-64, vi pubmed publisher
    ..This article reviews the new criteria for diagnosis and staging of AKI and summarizes the current understanding of the many causes of AKI and the approach to diagnosis and management...
  13. Larakeb A, Evrard S, Louillet F, Kwon T, Djaffar H, Llanas B, et al. Acute renal cortical necrosis due to acquired antiprotein S antibodies. Pediatr Nephrol. 2009;24:207-9 pubmed publisher
    ..In the light of this case report, protein S deficiency due to antibody inhibition should be carefully monitored anytime in the context of varicella when kidney insufficiency or necrosis occurs...
  14. Upadhaya B, Sharma A, Khaira A, Dinda A, Agarwal S, Tiwari S. Transient IgA nephropathy with acute kidney injury in a patient with dengue fever. Saudi J Kidney Dis Transpl. 2010;21:521-5 pubmed
    ..A repeated kidney biopsy 6 weeks after clinical recovery showed reversal of glomerular changes as well as resolution of mesangial IgA deposits...
  15. Boggs S, Cunnion K, Raafat R. Ceftriaxone-induced hemolysis in a child with Lyme arthritis: a case for antimicrobial stewardship. Pediatrics. 2011;128:e1289-92 pubmed publisher
    ..We review here the goals of antimicrobial stewardship and several strategies for achieving them. In addition, we briefly discuss the rare adverse drug event experienced by our patient...
  16. Schreiber A, Pham C, Hu Y, Schneider W, Luft F, Kettritz R. Neutrophil serine proteases promote IL-1? generation and injury in necrotizing crescentic glomerulonephritis. J Am Soc Nephrol. 2012;23:470-82 pubmed publisher
    ..These data suggest that the development of anti-MPO antibody-induced NCGN requires NSP-dependent IL-1? generation and that these processes may provide therapeutic targets for ANCA-mediated diseases in humans...
  17. Gao J, Chevalier J, Auh Y, Rubin J, Wang H, Sun L, et al. Correlation between Doppler parameters and renal cortical fibrosis in lupus nephritis: a preliminary observation. Ultrasound Med Biol. 2013;39:275-82 pubmed publisher
  18. Rathod K, Garg A, Chavhan G, Rathod N. Computed tomography as a diagnostic tool in acute renal cortical necrosis. J Assoc Physicians India. 2002;50:1451-2 pubmed
  19. Ali B, Al Qarawi A, Mahmoud O, Hashad M. Influence of spironolactone treatment on gentamicin-induced nephrotoxicity in rats. Basic Clin Pharmacol Toxicol. 2004;95:20-3 pubmed
    ..The present results indicate that spironolactone aggravates gentamicin-induced nephrotoxicity in the rat...
  20. Alfonzo A, Fox J, Imrie C, Roditi G, Young B. Acute renal cortical necrosis in a series of young men with severe acute pancreatitis. Clin Nephrol. 2006;66:223-31 pubmed
    ..We present a detailed account of each patient including diagnostic strategies and discuss the possible factors contributing to a favorable outcome in these patients...
  21. Ali S, Rizvi S, Muzaffar S, Ahmad A, Ali A, Hassan S. Renal cortical necrosis: a case series of nine patients & review of literature. J Ayub Med Coll Abbottabad. 2003;15:41-4 pubmed
    ..The purpose of this study is to review cases of renal cortical necrosis (RCN) which we came across during a period of five years, confirmed on needle biopsy specimens, with literature available so far...
  22. Lee H, Kim M, Jan M, Emala C. Anti-inflammatory and antinecrotic effects of the volatile anesthetic sevoflurane in kidney proximal tubule cells. Am J Physiol Renal Physiol. 2006;291:F67-78 pubmed
    ..These mechanisms may, in part, account for volatile anesthetics' protective effects against renal IR injury...
  23. Kumar S, Sharma A, Sodhi K, Wanchu A, Khandelwal N, Singh S. Renal cortical necrosis, peripheral gangrene, perinephric and retroperitoneal haematoma in a patient with a viper bite. Trop Doct. 2012;42:116-7 pubmed publisher
    ..We report the case of a patient developing gangrenous changes in a lower limb along with the development of perinepheric and retroperitoneal haematoma with acute cortical necrosis of the kidneys...
  24. Lim L, Tsai K, Hwang D, Kuo M, Chiu Y, Chen H. Anuric acute renal failure after elective abortion. Intern Med. 2011;50:1715-8 pubmed
    ..Early diagnosis of BRCN is essential not only for prognosis prediction but also for treatment decision. We suggest that any anuric patient in suspicion of BRCN should receive MRI study as soon as possible...
  25. Kumar R, Wang Z, Forsythe C, Fu Y, Chen Y, Yeh B. Dual energy CT monitoring of the renal corticomedullary sodium gradient in swine. Eur J Radiol. 2012;81:423-9 pubmed publisher
    ..To evaluate the feasibility of dual-energy CT (DECT) for monitoring dynamic changes in the renal corticomedullary sodium gradient in swine...
  26. Catalano O, Napolitano M, Leni D, Ticca C, Vanzulli A. Contrast enhanced computer tomography of two cases of bilateral acute cortical necrosis, one of which related to amphetamine abuse. Emerg Radiol. 2005;11:306-8 pubmed
  27. Phillips J, Green F, Davies J, Murray J. Pulmonary and systemic toxicity following exposure to nickel nanoparticles. Am J Ind Med. 2010;53:763-7 pubmed publisher
    ..Nickel particles <25 nm in diameter were identified in lung macrophages using transmission electron microscopy. High levels of nickel were measured in his urine and his kidneys showed evidence of acute tubular necrosis...
  28. Kamioka I, Nozu K, Fujita T, Kaito H, Tanaka R, Yoshiya K, et al. Prognosis and pathological characteristics of five children with non-Shiga toxin-mediated hemolytic uremic syndrome. Pediatr Int. 2007;49:196-201 pubmed
    ..Therefore the purpose of the present paper was to analyze renal biopsy findings and prognosis for five children with nStx-HUS...
  29. Pallet N, Bouvier N, Legendre C, Beaune P, Thervet E, Choukroun G, et al. Antiapoptotic properties of recombinant human erythropoietin protects against tubular cyclosporine toxicity. Pharmacol Res. 2010;61:71-5 pubmed publisher
    ..In conclusion, we describe here a new potential target of recombinant human erythropoietin and our results provide an interesting framework for further nephroprotective therapies based on recombinant human erythropoietin...
  30. Prakash J, Sen D, Kumar N, Kumar H, Tripathi L, Saxena R. Acute renal failure due to intrinsic renal diseases: review of 1122 cases. Ren Fail. 2003;25:225-33 pubmed
    ..Both acute GN and interstitial nephritis had excellent prognosis, however renal cortical necrosis was associated with a very high mortality...
  31. Khan S, Priyamvada S, Farooq N, Khan S, Khan M, Yusufi A. Protective effect of green tea extract on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. Pharmacol Res. 2009;59:254-62 pubmed publisher
    ..In conclusion, green tea ameliorates GM elicited nephrotoxicity and oxidative damage by improving antioxidant defense, tissue integrity and energy metabolism...
  32. Kalim S, Szczech L, Wyatt C. Acute kidney injury in HIV-infected patients. Semin Nephrol. 2008;28:556-62 pubmed publisher
  33. Azzollini N, Cugini D, Cassis P, Pezzotta A, Gagliardini E, Abbate M, et al. Propionyl-L-carnitine prevents early graft dysfunction in allogeneic rat kidney transplantation. Kidney Int. 2008;74:1420-8 pubmed publisher
    ..The efficacy of propionyl-L-carnitine to modulate ischemia-reperfusion injury during transplantation suggests that its use in human transplantation is worth testing...
  34. Rastaldi M. Necrotizing crescentic glomerulonephritis--a conditional knockout model discloses new therapeutic challenges. Nephrol Dial Transplant. 2007;22:1020-2 pubmed
  35. Fernández C, Ripollés T, Martinez M, Blay J, Pallardo L, Gavela E. Diagnosis of acute cortical necrosis in renal transplantation by contrast-enhanced ultrasound: a preliminary experience. Ultraschall Med. 2013;34:340-4 pubmed publisher
    ..To evaluate the use of contrast-enhanced ultrasound (CEUS) for diagnosis of cortical necrosis in renal allografts...
  36. Kruger B, Benck U, Singer T, Krämer B. [Drug-induced impairment of renal function]. Dtsch Med Wochenschr. 2012;137:1873-7 pubmed publisher
    ..Identification of risk factors and the introduction of prevention strategies should be an integral part of everybody's daily clinical work, especially in intensive care medicine due to the high susceptibility to AKI...
  37. Nwoko R, Plecas D, Garovic V. Acute kidney injury in the pregnant patient. Clin Nephrol. 2012;78:478-86 pubmed
    ..In pregnant women with pre-existing kidney disease, the degree of renal dysfunction is the major determining factor of pregnancy outcomes, which may further be complicated by a prior history of hypertension...
  38. Fischer T, Ebeling V, Giessing M, Muhler M, Filimonow S, Dieckhöfer J, et al. [A new method for standardized diagnosis following renal transplantation. Ultrasound with contrast enhancement]. Urologe A. 2006;45:38-45 pubmed
    ..This method is also helpful to detect and control acute rejections and to better visualize hematomas, deficits of perfusion, and tumors...
  39. Belen C, Budhiraja P, Bracamonte E, Popovtzer M. Biopsy-proven acute tubular necrosis associated with vancomycin in an adult patient. Ren Fail. 2012;34:502-5 pubmed publisher
    ..Here, we report a second case of biopsy-proven ATN resulting from vancomycin toxicity...
  40. Kute V, Vanikar A, Ghuge P, Goswami J, Patel M, Patel H, et al. Renal cortical necrosis and acute kidney injury associated with Plasmodium vivax: a neglected human malaria parasite. Parasitol Res. 2012;111:2213-6 pubmed publisher
    ..vivax malaria is benign by name but not always by nature. AKI associated with P. vivax malaria can lead to CKD. Further studies are needed to determine why P. vivax infections are becoming more severe...
  41. Prakash J, Tripathi K, Pandey L, Gadela S, Usha -. Renal cortical necrosis in pregnancy-related acute renal failure. J Indian Med Assoc. 1996;94:227-9 pubmed
    ..5%) of cortical necrosis in postabortum group in developed countries. The death occurred in most patients (14 ie, 93.3%) of cortical necrosis because of uraemic complications and sepsis...
  42. Mori K, Lee H, Rapoport D, Drexler I, Foster K, Yang J, et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest. 2005;115:610-21 pubmed
    ..We reveal what we believe to be a novel pathway of iron traffic that is activated in human and mouse renal diseases, and it provides a unique method for their treatment...
  43. Kim J, Kim G, Kang C, Park J. Bilateral acute renal cortical necrosis in SLE-associated antiphospholipid syndrome. Am J Kidney Dis. 2011;57:945-7 pubmed publisher
    ..This case shows the role of imaging in patients with bilateral ARCN in systemic lupus erythematosus-related antiphospholipid syndrome...
  44. Saotome T, Ishikawa K, May C, Birchall I, Bellomo R. The impact of experimental hypoperfusion on subsequent kidney function. Intensive Care Med. 2010;36:533-40 pubmed publisher
    ..To investigate the short- and medium-term renal hemodynamic and functional responses to both short and sustained hypoperfusion...
  45. Vigneau C, Daugas E, Maury E, Sokol H, Offenstadt G, Rossert J, et al. Renal cortical necrosis related to paraneoplastic antiphospholipid syndrome. Am J Kidney Dis. 2006;47:1072-4 pubmed
    ..This case describes the first association of antiphospholipid syndrome to epidermoid lung cancer, shown by cortical bilateral necrosis. It also emphasizes the utility of renal biopsy in case of an unusual acute renal failure...
  46. Miura N, Aoyama R, Kitagawa W, Yamada H, Nishikawa K, Imai H. Proteinase 3-antineutrophil cytoplasmic antibody-(PR3-ANCA) positive necrotizing glomerulonephritis after restarting sulphasalazine treatment. Clin Nephrol. 2009;71:74-9 pubmed
    ..One month after steroid therapy, the pleural effusion disappeared, and PR3-ANCA titer normalized 3 months later. This case suggests that sulphasalazine can induce PR3-ANCA-positive necrotizing glomerulonephritis...
  47. Leroy F, Bridoux F, Abou Ayache R, Belmouaz S, Desport E, Thierry A, et al. [Quinine-induced renal bilateral cortical necrosis]. Nephrol Ther. 2008;4:181-6 pubmed publisher
    ..Caution is required for the prescription of quinine derivates, which should be avoided in patients experienced on adverse reaction to the drug...
  48. Edwards J, Diamantakos E, Peuler J, Lamar P, Prozialeck W. A novel method for the evaluation of proximal tubule epithelial cellular necrosis in the intact rat kidney using ethidium homodimer. BMC Physiol. 2007;7:1 pubmed
    ..Total cell number was determined from the DAPI staining in random microscopic fields and the number of necrotic cells in the same field was determined by ethidium homodimer labeling...
  49. Borgatti Jeffreys A, Hooser S, Miller M, Lucroy M. Phase I clinical trial of the use of zinc phthalocyanine tetrasulfonate as a photosensitizer for photodynamic therapy in dogs. Am J Vet Res. 2007;68:399-404 pubmed
  50. Takahashi S, Kanetake J, Kanawaku Y, Funayama M. Brain death with calcium oxalate deposition in the kidney: clue to the diagnosis of ethylene glycol poisoning. Leg Med (Tokyo). 2008;10:43-5 pubmed
    ..We considered that the amount and the persistence of the calcium oxalate deposition in the kidney may afford a best clue to the postmortem diagnosis of ethylene glycol poisoning even in the chronic stage...
  51. Sue Y, Cheng C, Chang C, Chou Y, Chen C, Juan S. Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells. Nephrol Dial Transplant. 2009;24:769-77 pubmed publisher
    ..Haem oxygenase-1 (HO-1) induction by TMP has also been shown to attenuate myocardial ischaemia/reperfusion injury in rats...
  52. Kanodia K, Vanikar A, Patel R, Shah P, Nagpal M, Firoz A, et al. De novo collapsing glomerulopathy in a renal allograft recipient. Saudi J Kidney Dis Transpl. 2008;19:793-5 pubmed
    ..CG is known to recur in renal allograft and rarely de novo. We report de novo CG 3 years post-transplant in a patient who received renal allograft from haplo-identical type donor...
  53. Prakash J, Vohra R, Wani I, Murthy A, Srivastva P, Tripathi K, et al. Decreasing incidence of renal cortical necrosis in patients with acute renal failure in developing countries: a single-centre experience of 22 years from Eastern India. Nephrol Dial Transplant. 2007;22:1213-7 pubmed
    ..However, RCN incidence is higher in developing countries ranging from 6-7% of all cases of acute renal failure. The present study describes changing trends in the clinical spectrum of RCN in patients with ARF in Eastern India...