kidney diseases

Summary

Summary: Pathological processes of the KIDNEY or its component tissues.

Top Publications

  1. Nishijima T, Komatsu H, Higasa K, Takano M, Tsuchiya K, Hayashida T, et al. Single nucleotide polymorphisms in ABCC2 associate with tenofovir-induced kidney tubular dysfunction in Japanese patients with HIV-1 infection: a pharmacogenetic study. Clin Infect Dis. 2012;55:1558-67 pubmed publisher
    ..The aim of this study was to determine the association between polymorphisms in genes encoding drug transporters and KTD in Japanese patients treated with tenofovir...
  2. Yaqub S, Kashif W, Hussain S. Non-diabetic renal disease in patients with type-2 diabetes mellitus. Saudi J Kidney Dis Transpl. 2012;23:1000-7 pubmed publisher
    ..Performing renal biopsy in diabetics with no extrarenal end organ damage other than nephropathy helps to diagnose and treat NDRD. This is the first report from Pakistan documenting the prevalence of NDRD in patients with type-2 diabetes...
  3. Wyburn K, Chadban S, Kwan T, Alexander S, Wu H. Interleukin-18 binding protein therapy is protective in adriamycin nephropathy. Am J Physiol Renal Physiol. 2013;304:F68-76 pubmed publisher
    ..The protective effect of IL-18BP therapy illustrates the importance of immune mediators in chronic proteinuric kidney disease and highlights the potential of IL-18BP therapy...
  4. Hofmann W, Ehrich J, Guder W, Keller F, Scherberich J. Diagnostic pathways for exclusion and diagnosis of kidney diseases. Clin Lab. 2012;58:871-89 pubmed
    ..The present paper describes the contents of these pathways regarding glomerular filtration rate, hematuria, leukocyturia and proteinuria...
  5. Ruseva M, Vernon K, Lesher A, Schwaeble W, Ali Y, Botto M, et al. Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency. J Am Soc Nephrol. 2013;24:43-52 pubmed publisher
    ..In summary, during uncontrolled activation of C3 driven by complete CFH deficiency, properdin influences the intraglomerular localization of C3, suggesting that therapeutic inhibition of properdin would be detrimental in this setting. ..
  6. Morales E, Millet V, Rojas Rivera J, Huerta A, Gutierrez E, Gutierrez Solis E, et al. Renoprotective effects of mineralocorticoid receptor blockers in patients with proteinuric kidney diseases. Nephrol Dial Transplant. 2013;28:405-12 pubmed publisher
    ..demonstrated a short-term antiproteinuric effect of mineralocorticoid receptor blockers (MRB) on proteinuric kidney diseases, but no information is available about the long-term persistence (>1 year) of such reduction in ..
  7. Yang J, Chen J, Yan J, Zhang L, Chen G, He L, et al. Effect of interleukin 6 deficiency on renal interstitial fibrosis. PLoS ONE. 2012;7:e52415 pubmed publisher
    ..Our results indicate that interleukin 6 does not play a significant role in the recruitment of bone marrow-derived fibroblast precursors and the development of renal fibrosis...
  8. Lees G. Kidney diseases caused by glomerular basement membrane type IV collagen defects in dogs. J Vet Emerg Crit Care (San Antonio). 2013;23:184-93 pubmed publisher
    ..To review the pathogenesis, as well as the clinical and pathologic features of canine glomerular diseases caused by genetic type IV collagen defects...
  9. Eckardt K, Coresh J, Devuyst O, Johnson R, Kottgen A, Levey A, et al. Evolving importance of kidney disease: from subspecialty to global health burden. Lancet. 2013;382:158-69 pubmed publisher
    ..Collaboration across general and specialised health-care professionals is needed to fully address the challenge of prevention of acute and chronic kidney disease and improve outcomes. ..

More Information

Publications103 found, 100 shown here

  1. LeBleu V, Taduri G, O Connell J, Teng Y, Cooke V, Woda C, et al. Origin and function of myofibroblasts in kidney fibrosis. Nat Med. 2013;19:1047-53 pubmed publisher
    ..Our data suggest that targeting diverse pathways is required to substantially inhibit the composite accumulation of myofibroblasts in kidney fibrosis. ..
  2. Siegel D, Martin T, Nooka A, Harvey R, Vij R, Niesvizky R, et al. Integrated safety profile of single-agent carfilzomib: experience from 526 patients enrolled in 4 phase II clinical studies. Haematologica. 2013;98:1753-61 pubmed publisher
    ..The tolerable safety profile allows for administration of full-dose carfilzomib, both for extended periods and in a wide spectrum of patients with advanced multiple myeloma, including those with pre-existing comorbidities. ..
  3. Lee J, Hwang I, Lee J, Lee H, Jeong L, Ha H. The selective A3AR antagonist LJ-1888 ameliorates UUO-induced tubulointerstitial fibrosis. Am J Pathol. 2013;183:1488-1497 pubmed publisher
  4. Nangaku M, Rosenberger C, Heyman S, Eckardt K. Regulation of hypoxia-inducible factor in kidney disease. Clin Exp Pharmacol Physiol. 2013;40:148-57 pubmed publisher
    ..In addition, an acute hypoxic insult may induce long-lasting changes, possibly including epigenetic modifications induced by HIF. These observations suggest a complex interaction between AKI and CKD via hypoxia and HIF activation...
  5. Speeckaert M, Speeckaert R, Laute M, Vanholder R, Delanghe J. Tumor necrosis factor receptors: biology and therapeutic potential in kidney diseases. Am J Nephrol. 2012;36:261-70 pubmed publisher
    ..This article reviews the general characteristics, the analytical aspects and the biology of TNFRs in this domain. In addition, the potential therapeutic application of specific TNFR blockers is discussed...
  6. Kawakami T, Ren S, Duffield J. Wnt signalling in kidney diseases: dual roles in renal injury and repair. J Pathol. 2013;229:221-31 pubmed publisher
    ..pathway in nephrogenesis is well established, recent investigations have shown its involvement in many adult kidney diseases, including ischaemic kidney injury, glomerular diseases, diabetic nephropathy, interstitial fibrosis and ..
  7. Laprise C, Baril J, Dufresne S, Trottier H. Association between tenofovir exposure and reduced kidney function in a cohort of HIV-positive patients: results from 10 years of follow-up. Clin Infect Dis. 2013;56:567-75 pubmed publisher
  8. Kocełak P, Olszanecka Glinianowicz M, Chudek J. Fibroblast growth factor 23--structure, function and role in kidney diseases. Adv Clin Exp Med. 2012;21:391-401 pubmed
    ..So far, little evidence supports direct FGF-23 toxicity...
  9. Saeki T, Kawano M, Mizushima I, Yamamoto M, Wada Y, Nakashima H, et al. The clinical course of patients with IgG4-related kidney disease. Kidney Int. 2013;84:826-33 pubmed publisher
    ..A large-scale prospective study to formulate more useful treatment strategies is necessary. ..
  10. Cao J, Wang W, Li Y, Xia J, Peng Y, Zhang Y, et al. Artesunate attenuates unilateral ureteral obstruction-induced renal fibrosis by regulating the expressions of bone morphogenetic protein-7 and uterine sensitization-associated gene-1 in rats. Int Urol Nephrol. 2016;48:619-29 pubmed publisher
    ..Accordingly, Art may become a potential preventive or therapeutic agent for chronic kidney diseases.
  11. Kuwabara M, Niwa K, Ohtahara A, Hamada T, Miyazaki S, Mizuta E, et al. Prevalence and complications of hypouricemia in a general population: A large-scale cross-sectional study in Japan. PLoS ONE. 2017;12:e0176055 pubmed publisher
    ..However, the prevalence of kidney diseases among hypouricemic subjects has not been evaluated...
  12. Granado D, Muller D, Krausel V, Kruzel Davila E, Schuberth C, Eschborn M, et al. Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion. J Am Soc Nephrol. 2017;28:3227-3238 pubmed publisher
    Population genetic approaches have uncovered a strong association between kidney diseases and two sequence variants of the APOL1 gene, called APOL1 risk variant G1 and variant G2, compared with the nonrisk G0 allele...
  13. Tirloni C, Palozi R, Tomazetto T, Vasconcelos P, Souza R, Dos Santos A, et al. Ethnopharmacological approaches to kidney disease-prospecting an indigenous species from Brazilian Pantanal. J Ethnopharmacol. 2018;211:47-57 pubmed publisher
    ..is popularly used by the population of the Brazilian Pantanal for the treatment of different types of kidney diseases, no study has been carried out to prove this ethnobotanical indication...
  14. Devuyst O, Pattaro C. The UMOD Locus: Insights into the Pathogenesis and Prognosis of Kidney Disease. J Am Soc Nephrol. 2018;29:713-726 pubmed publisher
    ..In this brief review, we use the UMOD paradigm to describe how population genetic studies can yield insight into the pathogenesis and prognosis of kidney diseases.
  15. Mattoo T, Chesney R, Greenfield S, Hoberman A, Keren R, Mathews R, et al. Renal Scarring in the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) Trial. Clin J Am Soc Nephrol. 2016;11:54-61 pubmed publisher
    ..Preexisting and new renal scars occurred significantly more in renal units with grade 4 VUR than in those with low-grade or no VUR. Antimicrobial prophylaxis did not decrease the risk of renal scarring. ..
  16. Tsukada N, Ikeda M, Shingaki S, Miyazaki K, Meshitsuka S, Yoshiki Y, et al. High-dose melphalan and autologous stem cell transplantation for systemic light-chain amyloidosis: a single institution retrospective analysis of 40 cases. Int J Hematol. 2016;103:299-305 pubmed publisher
    ..It is also important to develop additional treatment for patients who do not achieve a hematological and/or organ response. ..
  17. De Tomasi L, David P, Humbert C, Silbermann F, Arrondel C, Tores F, et al. Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice. Am J Hum Genet. 2017;101:803-814 pubmed publisher
    ..This demonstrates that GREB1L plays a major role in early metanephros and genital development in mice and humans. ..
  18. Fournier P, Fourcade J, Roncalli J, Salvayre R, Galinier M, Caussé E. Homocysteine in Chronic Heart Failure. Clin Lab. 2015;61:1137-45 pubmed
    ..HHcy is common in CHF patients and is associated with an increased risk of death at 5 years. We suggest that Hcy can be used in clinical practice as an additional risk marker in CHF patients with various medications. ..
  19. Weckerle A, Snipes J, Cheng D, Gebre A, Reisz J, Murea M, et al. Characterization of circulating APOL1 protein complexes in African Americans. J Lipid Res. 2016;57:120-30 pubmed publisher
    ..Serum HPR was less abundant on complex B in individuals with G1 and G2 renal-risk variant genotypes, relative to G0 (P = 0.0002-0.037). These circulating complexes may play roles in HDL metabolism and susceptibility to CVD. ..
  20. Grubb S, Stuart J, Harper H. Sudden onset flank pain: Spontaneous renal rupture. Am J Emerg Med. 2017;35:1787.e1-1787.e3 pubmed publisher
    ..Likely presentations and risk factors for atraumatic renal rupture will be discussed as well as ED management and definitive treatment options. ..
  21. Galvan D, Green N, Danesh F. The hallmarks of mitochondrial dysfunction in chronic kidney disease. Kidney Int. 2017;92:1051-1057 pubmed publisher
    ..mitochondrial remodeling and cellular damage, including the role of microRNAs and long noncoding RNAs, are examined with the final goal of identifying mitochondrial targets to improve treatment of patients with chronic kidney diseases.
  22. Ma L, Liu Y, Landry N, El Achkar T, Lieske J, Wu X. Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia. PLoS ONE. 2017;12:e0186769 pubmed publisher
    Hereditary mutations in Tamm-Horsfall protein (THP/uromodulin) gene cause autosomal dominant kidney diseases characterized by juvenile-onset hyperuricemia, gout and progressive kidney failure, although the disease pathogenesis remains ..
  23. Ingelfinger J, Kalantar Zadeh K, Schaefer F. Averting the legacy of kidney disease - focus on childhood. Afr J Prim Health Care Fam Med. 2016;8:e1-5 pubmed publisher
    ..Our hope is that World Kidney Day will inform the general public, policymakers and caregivers about the needs and possibilities surrounding kidney disease in childhood. ..
  24. Nogueira A, Peixoto F, Oliveira M, Pires C, Colaço B, Oliveira P, et al. The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction. Biomed Res Int. 2017;2017:5125980 pubmed publisher
    ..However, CAA administration slightly improves some parameters of renal function. Conclusions. These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress. ..
  25. Gai Z, Gui T, Hiller C, Kullak Ublick G. Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice. J Biol Chem. 2016;291:2397-411 pubmed publisher
    ..In summary, FXR activation maintains endogenous glutathione homeostasis and protects the kidney in uninephrectomized mice from obesity-induced injury. ..
  26. Codsi E, Garovic V, Gonzalez Suarez M, Milic N, Borowski K, Rose C, et al. Longitudinal characterization of renal proximal tubular markers in normotensive and preeclamptic pregnancies. Am J Physiol Regul Integr Comp Physiol. 2017;312:R773-R778 pubmed publisher
    ..However, this was not matched by abnormalities in markers previously associated with tubular cell injury (KIM-1, IGFBP-7, and TIMP-2). ..
  27. Bagchi S, Mittal P, Singh G, Agarwal S, Singh L, Bhowmik D, et al. Pattern of biopsy-proven kidney disease in the elderly in a tertiary care hospital in India: a clinicopathological study. Int Urol Nephrol. 2016;48:553-60 pubmed publisher
    An aging population is an important demographic issue in India. The knowledge base about kidney diseases among the elderly Indians is inadequate...
  28. Miyoshi T, Misumi N, Hiraike M, Mihara Y, Nishino T, Tsuruta M, et al. Risk Factors Associated with Cisplatin-Induced Nephrotoxicity in Patients with Advanced Lung Cancer. Biol Pharm Bull. 2016;39:2009-2014 pubmed
    ..7; p=0.002) and hypoalbuminemia (odds ratio=6.99 p=0.025 significantly correlated with nephrotoxicity. In conclusion, cardiac disease and low baseline Alb values are possible risk factors for CIN. ..
  29. Li W, Yang K, Zhu P, Zhao H, Song Y, Liu K, et al. Genistein Ameliorates Ischemia/Reperfusion-Induced Renal Injury in a SIRT1-Dependent Manner. Nutrients. 2017;9: pubmed publisher
    ..Hence, our results provided further experimental basis for the potential use of genistein for the treatment of kidney disease with deficiency of SIRT1 activity. ..
  30. Derlin T, Gueler F, Bräsen J, Schmitz J, Hartung D, Herrmann T, et al. Integrating MRI and Chemokine Receptor CXCR4-Targeted PET for Detection of Leukocyte Infiltration in Complicated Urinary Tract Infections After Kidney Transplantation. J Nucl Med. 2017;58:1831-1837 pubmed publisher
    ..This novel methodology may refine the characterization of infectious and inflammatory kidney diseases and may serve as a platform for future clinical studies targeting allograft infection.
  31. Shah N, Khan M, Nigussie D. Phytochemical investigation and nephroprotective potential of Sida cordata in rat. BMC Complement Altern Med. 2017;17:388 pubmed publisher
    ..These results are an evidence of the renal protective role of S.cordat ethyl acetate fraction against CCl4 induced nephrotoxicity in rats which may be due to its antioxidant compounds. ..
  32. Taslakian B, Sebaaly M, Al Kutoubi A. Patient Evaluation and Preparation in Vascular and Interventional Radiology: What Every Interventional Radiologist Should Know (Part 2: Patient Preparation and Medications). Cardiovasc Intervent Radiol. 2016;39:489-99 pubmed publisher
    ..In this second part, we complete the comprehensive, methodical review of pre-procedural care and patient preparation before vascular and interventional radiology procedures. ..
  33. Goto N, Okada M, Yamamoto T, Tsujita M, Hiramitsu T, Narumi S, et al. Association of Dialysis Duration with Outcomes after Transplantation in a Japanese Cohort. Clin J Am Soc Nephrol. 2016;11:497-504 pubmed publisher
    ..Even in Japan, where the long-term outcomes of patients on hemodialysis are excellent, PKT could be beneficial to reduce DWFG, graft loss, and post-transplant CVD. ..
  34. Matsushita K, Ballew S, Coresh J, Arima H, Arnlov J, Cirillo M, et al. Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data. Lancet Diabetes Endocrinol. 2017;5:718-728 pubmed publisher
    ..American Heart Association, US National Kidney Foundation, and US National Institute of Diabetes and Digestive and Kidney Diseases.
  35. He Y, Li X, Wang J, Yang Q, Yao B, Zhao Y, et al. Synthesis, characterization and evaluation cytotoxic activity of silver nanoparticles synthesized by Chinese herbal Cornus officinalis via environment friendly approach. Environ Toxicol Pharmacol. 2017;56:56-60 pubmed publisher
    ..Its fruits have been used in many traditional Chinese medicine prescriptions to treat kidney diseases, diabetes, cancer and shock...
  36. Zhou Y, Li W, Herath C, Xia J, Hu B, Song F, et al. Off-Hour Admission and Mortality Risk for 28 Specific Diseases: A Systematic Review and Meta-Analysis of 251 Cohorts. J Am Heart Assoc. 2016;5:e003102 pubmed publisher
    ..Specialists, nurses, as well as hospital administrators and health policymakers can take these findings into consideration to improve the quality and continuity of medical services. ..
  37. Sabler I, Berkovitch M, Sandbank J, Kozer E, Dagan Z, Goldman M, et al. Exposure to Hyperbaric Oxygen Intensified Vancomycin-Induced Nephrotoxicity in Rats. PLoS ONE. 2016;11:e0152554 pubmed publisher
    ..This study demonstrated that exposure to hyperbaric oxygen intensified vancomycin-induced nephrotoxicity in rats. ..
  38. Norton J, Dodson J, Newman D, Rogers R, Fairman A, Coons H, et al. Nonbiologic factors that impact management in women with urinary incontinence: review of the literature and findings from a National Institute of Diabetes and Digestive and Kidney Diseases workshop. Int Urogynecol J. 2017;28:1295-1307 pubmed publisher
    ..factors (NBF) on UI management and treatment response, the National Institute of Diabetes and Digestive and Kidney Diseases convened a workshop for clinical and psychosocial researchers...
  39. Hains D, Cohen H, McCarville M, Ellison E, Huffman A, Glass S, et al. Elucidation of Renal Scars in Children With Vesicoureteral Reflux Using Contrast-Enhanced Ultrasound: A Pilot Study. Kidney Int Rep. 2017;2:420-424 pubmed publisher
    ..Because the contrast agent is rapidly cleared, contrast images must be obtained within minutes of administration. CEUS has been used in a variety of organ systems, but its use in pediatric kidney diseases is limited.
  40. Topaloglu R, Batu E, Orhan D, Ozen S, Besbas N. Anti-interleukin 1 treatment in secondary amyloidosis associated with autoinflammatory diseases. Pediatr Nephrol. 2016;31:633-40 pubmed publisher
    ..Anti-IL1 drugs are important to prevent further amyloid accumulation; however, new treatment strategies are needed to target the amyloid deposits. ..
  41. Weigel F, Lemke A, Tönshoff B, Pape L, Fehrenbach H, Henn M, et al. Febrile urinary tract infection after pediatric kidney transplantation: a multicenter, prospective observational study. Pediatr Nephrol. 2016;31:1021-8 pubmed publisher
    ..This prospective study confirms a high incidence of fUTI after pediatric KTx, which is not restricted to patients with CAKUT; fUTIs have a negative impact on graft function during the infectious episode but not on 2-year graft outcome. ..
  42. Yasuda H, Amakasu K, Tochigi Y, Katayama K, Suzuki H. Renal Function and Hematology in Rats with Congenital Renal Hypoplasia. Comp Med. 2016;66:10-20 pubmed
  43. Pearce F, Craven A, Merkel P, Luqmani R, Watts R. Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody-associated vasculitis. Rheumatology (Oxford). 2017;56:1962-1969 pubmed publisher
    ..This study confirms the previously observed differential occurrence of MPO-AAV and PR3-AAV between different ethnic groups. ..
  44. Taranta Janusz K, Wasilewska A, Roszkowska R, Michaluk Skutnik J. Is urine intercellular adhesion molecule-1 a marker of renal disorder in children with ureteropelvic junction obstruction?. Biomarkers. 2016;21:123-8 pubmed publisher
    ..01), and in severe HN when compared with mild HN (p<0.05). It seemed to us that uICAM-1 is a biomarker of renal disorder, and might have the potential to predict which patients will require surgery. ..
  45. Tong G, Kumar S, Chong K, Shah N, Wong M, Zimmet J, et al. Risk of contrast-induced nephropathy for patients receiving intravenous vs. intra-arterial iodixanol administration. Abdom Radiol (NY). 2016;41:91-9 pubmed publisher
    ..28 and 2.5; p < 0.023 and <0.006, respectively). Elevation in serum creatinine due to intravenous and intra-arterial iodixanol administration is infrequent and is not more common than after unenhanced CT scans. ..
  46. Dotsch J, Alejandre Alcazar M, Janoschek R, Nüsken E, Weber L, Nüsken K. Perinatal programming of renal function. Curr Opin Pediatr. 2016;28:188-94 pubmed publisher
    ..The use of transgenic animal models might help to obtain a deeper insight into the underlying mechanisms. ..
  47. Wen J, Liu X, Wang Z, Li T, Wahlqvist M. Melamine-contaminated milk formula and its impact on children. Asia Pac J Clin Nutr. 2016;25:697-705 pubmed publisher
  48. Piret S, Olinger E, Reed A, Nesbit M, Hough T, Bentley L, et al. A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress. Dis Model Mech. 2017;10:773-786 pubmed publisher
  49. Elsherbiny N, Maysarah N, El Sherbiny M, Al Gayyar M. Renal protective effects of thymoquinone against sodium nitrite-induced chronic toxicity in rats: Impact on inflammation and apoptosis. Life Sci. 2017;180:1-8 pubmed publisher
    ..This can be attributed to its ability to dampen oxidative stress, restore the normal balance between pro- and anti-inflammatory cytokines and protect renal tissue form extrinsic and intrinsic apoptosis. ..
  50. Gupta A, Campion Smith J, Hayes W, Deal J, Gilbert R, Inward C, et al. Positive trends in paediatric renal biopsy service provision in the UK: a national survey and re-audit of paediatric renal biopsy practice. Pediatr Nephrol. 2016;31:613-21 pubmed publisher
    ..0008) and major complications (15.3 % vs 3.3 %, P = 0.0015) compared with 16-gauge needles. Percutaneous renal biopsy remains a safe procedure in children, thus improving family-centered service provision in the UK. ..
  51. Zhang A, Liu Q, Zhao H, Zhou X, Sun H, Nan Y, et al. Phenotypic characterization of nanshi oral liquid alters metabolic signatures during disease prevention. Sci Rep. 2016;6:19333 pubmed publisher
    ..This work showed that the metabolomics method was a powerful approach for studying the phenotypic characterization of disease's syndrome during disease prevention and its intervention mechanism. ..
  52. Khan H, Singh R, Tiwari R, Gangopadhyay S, Roy S, SINGH D, et al. Mercury exposure induces cytoskeleton disruption and loss of renal function through epigenetic modulation of MMP9 expression. Toxicology. 2017;386:28-39 pubmed publisher
    ..Our studies thus show how MeHg could epigenetically modulate MMP9 to promote cytoskeleton disruption leading to loss of renal function. ..
  53. Basu A, Singha Roy S, Bhattacharjee A, Bhuniya A, Baral R, Biswas J, et al. Vanadium(III)-L-cysteine protects cisplatin-induced nephropathy through activation of Nrf2/HO-1 pathway. Free Radic Res. 2016;50:39-55 pubmed publisher
    ..001) enhanced CDDP-mediated cytotoxicity in MCF-7 and NCI-H520 human cancer cell lines. Thus, VC-III can serve as a suitable chemoprotectant and increase the therapeutic window of CDDP in cancer patients. ..
  54. De Miguel C, Speed J, Kasztan M, Gohar E, Pollock D. Endothelin-1 and the kidney: new perspectives and recent findings. Curr Opin Nephrol Hypertens. 2016;25:35-41 pubmed publisher
    ..More animal and clinical studies are needed to better understand the dimorphic control of this system by sex hormones. ..
  55. Kajimoto K, Sato N, Takano T. eGFR and Outcomes in Patients with Acute Decompensated Heart Failure with or without Elevated BUN. Clin J Am Soc Nephrol. 2016;11:405-12 pubmed publisher
  56. Chen K, Hsu H, Yang H, Tian Y, Ko Y, Yang C, et al. Inhibition of spleen tyrosine kinase (syk) suppresses renal fibrosis through anti-inflammatory effects and down regulation of the MAPK-p38 pathway. Int J Biochem Cell Biol. 2016;74:135-44 pubmed publisher
    ..Syk inhibition could have therapeutic potential for the treatment of renal tubulointerstitial fibrosis. ..
  57. Zhou X, Zhang A, Wang L, Tan Y, Guan Y, Han Y, et al. Novel chinmedomics strategy for discovering effective constituents from ShenQiWan acting on ShenYangXu syndrome. Chin J Nat Med. 2016;14:561-81 pubmed publisher
    ..In conclusion, chinmedomics is a useful strategy for discovery of potentially effective constituents from complex TCM formulae. ..
  58. Lioudaki E, Whyte M, Androulakis E, Stylianou K, Daphnis E, Ganotakis E. Renal Effects of SGLT-2 Inhibitors and Other Anti-diabetic Drugs: Clinical Relevance and Potential Risks. Clin Pharmacol Ther. 2017;102:470-480 pubmed publisher
    ..Sodium-glucose cotransporter (SGLT)-2 inhibitors have emerged as a new, promising class of antidiabetic agents with actions that seem to extend beyond their hypoglycemic effect...
  59. Sorigue M, Sancho J, Pineda A, García O, Lopez D, Moreno M, et al. Incidence and prognostic significance of nephrotoxicity in patients receiving eshap as salvage therapy for lymphoma. Leuk Res. 2017;58:98-101 pubmed publisher
    ..50% [22%-78%]). Outpatient administration of ESHAP may not be optimal for all patients and the impact of ESHAP-induced renal failure on ASCT outcomes in lymphoma needs to be assessed in prospective studies. ..
  60. Zununi Vahed S, Poursadegh Zonouzi A, Mahmoodpoor F, Samadi N, Ardalan M, Omidi Y. Circulating miR-150, miR-192, miR-200b, and miR-423-3p as Non-invasive Biomarkers of Chronic Allograft Dysfunction. Arch Med Res. 2017;48:96-104 pubmed publisher
    ..Therefore, they are proposed to be considered as potential diagnostic biomarkers for monitoring of renal graft function. ..
  61. Yasinta M, Che R, Hu C, Du X, Ding G, Huang S, et al. Use of off-label nephrology-related drugs in hospitalized pediatric patients: a retrospective study. World J Pediatr. 2016;12:236-42 pubmed publisher
    ..Analyzing the off-label conditions from different perspectives may lead to various results. More clinical research into drugs for infants and younger children is needed so as to update drug descriptions. ..
  62. Emma F, Montini G, Parikh S, Salviati L. Mitochondrial dysfunction in inherited renal disease and acute kidney injury. Nat Rev Nephrol. 2016;12:267-80 pubmed publisher
    ..Potential therapies that target mitochondrial dysfunction or promote mitochondrial regeneration are being developed to limit renal damage during AKI and promote repair of injured tissue. ..
  63. Vymetal J, Skácelová M, Smrzova A, Klicova A, Schubertova M, Horak P, et al. Emergency situations in rheumatology with a focus on systemic autoimmune diseases. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016;160:20-9 pubmed publisher
    ..This aim of this paper is to overview emergency situations which can be encountered in the care of patients with autoimmune systemic diseases and vasculitides...
  64. Yavuz S, Ece A, Corapli M, Ilter C, Guven R. Nutcracker syndrome complicating with renal abscess. J Pak Med Assoc. 2016;66:470-2 pubmed
    ..These two entities are extremely rare and their coincidence has not previously been described in literature. Here, we report a case of a 10-year-old girl who developed left renal abscess probably due to nutcracker syndrome. ..
  65. Börgeson E, Wallenius V, Syed G, Darshi M, Lantero Rodriguez J, Biörserud C, et al. AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin. Diabetologia. 2017;60:729-739 pubmed publisher
    ..Furthermore, AICAR reduced inflammation in human adipose tissue explants, suggesting by proof-of-principle that the drug may reduce obesity-induced complications in humans. ClinicalTrials.gov NCT02322073. ..
  66. Schaeffer C, Merella S, Pasqualetto E, Lazarevic D, Rampoldi L. Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response. PLoS ONE. 2017;12:e0175970 pubmed publisher
    ..This sets the bases for future work to develop novel therapeutic strategies through modulation of ER homeostasis and associated protein degradation pathways. ..
  67. Quintanilha J, de Sousa V, Visacri M, Amaral L, Santos R, Zambrano T, et al. Involvement of cytochrome P450 in cisplatin treatment: implications for toxicity. Cancer Chemother Pharmacol. 2017;80:223-233 pubmed publisher
    ..Therefore, there is a need for a deeper investigation focusing on cisplatin toxicity mediated by CYP450 enzymes, which would undoubtedly contribute to a better understanding of the mechanisms that have been implicated so far. ..
  68. Ameda S, Kuroda H, Yamada M, Sato K, Miura S, Sakano H, et al. Thrombotic microangiopathy due to malignant hypertension complicated with late-onset bleeding after renal biopsy. Rinsho Ketsueki. 2017;58:637-642 pubmed publisher
    ..Renal failure did not improve, and continuous hemodiafiltration was needed. This procedure stabilized blood pressure and improved the TMA...
  69. Loboda A, Stachurska A, Sobczak M, Podkalicka P, Mucha O, Jozkowicz A, et al. Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo. Toxicology. 2017;389:42-52 pubmed publisher
    ..The lack of Nrf2 enhances susceptibility to mycotoxin-induced pathologies, suggesting that modulation of the Nrf2 pathway may provide a therapeutic approach to treat OTA-triggered renal diseases. ..
  70. Hafer C, Golla P, Gericke M, Eden G, Beutel G, Schmidt J, et al. Membrane versus centrifuge-based therapeutic plasma exchange: a randomized prospective crossover study. Int Urol Nephrol. 2016;48:133-8 pubmed publisher
    ..Especially in centers performing many procedures per year, cTPE in contrast to mTPE can reduce treatment time without compromising treatment efficacy. ..
  71. Salama S, Arab H, Maghrabi I, Hassan M, Alsaeed M. Gamma-Glutamyl Cysteine Attenuates Tissue Damage and Enhances Tissue Regeneration in a rat Model of Lead-Induced Nephrotoxicity. Biol Trace Elem Res. 2016;173:96-107 pubmed publisher
  72. López Mejías R, Genre F, Remuzgo Martínez S, Sevilla Pérez B, Castañeda S, Llorca J, et al. Interleukin 1 beta (IL1ß) rs16944 genetic variant as a genetic marker of severe renal manifestations and renal sequelae in Henoch-Schönlein purpura. Clin Exp Rheumatol. 2016;34:S84-8 pubmed
    ..0076, OR=2.20, 95% CI: 1.17-4.14). Our results support that the IL1ß rs16944 polymorphism may be a potential marker of severe renal manifestations and renal sequelae in HSP. ..
  73. Jamshidzadeh A, Heidari R, Golzar T, Derakhshanfar A. Effect of Eisenia foetida Extract against Cisplatin-Induced Kidney Injury in Rats. J Diet Suppl. 2016;13:551-9 pubmed publisher
    ..This investigation concluded that Eisenia foetida extract ameliorated cisplatin-induced nephrotoxicity. This protection might be mediated by preventing cisplatin-induced oxidative stress...
  74. Kim T, Kim Y, Seo C, Kim H, Park S, Lee M, et al. Elsholtzia ciliata (Thunb.) Hylander attenuates renal inflammation and interstitial fibrosis via regulation of TGF-ß and Smad3 expression on unilateral ureteral obstruction rat model. Phytomedicine. 2016;23:331-9 pubmed publisher
    ..Renal interstitial fibrosis is characterized by excessive accumulation of extracellular matrix, which leads to end-stage renal failure...
  75. Hohenstein B. Lipoprotein(a) in nephrological patients. Clin Res Cardiol Suppl. 2017;12:27-30 pubmed publisher
    ..Further evaluation of Lp(a) in CKD is very important to provide appropriate treatment to patients with high Lp(a) levels, even in the presence of CKD. ..
  76. Velez J, Arif E, Rodgers J, Hicks M, Arthur J, Nihalani D, et al. Deficiency of the Angiotensinase Aminopeptidase A Increases Susceptibility to Glomerular Injury. J Am Soc Nephrol. 2017;28:2119-2132 pubmed publisher
    ..The augmented AngII-mediated kidney injury observed in association with increased intrarenal AngII accumulation in the absence of APA suggests a protective metabolizing role of APA in AngII-mediated glomerular diseases. ..
  77. Du J, Li R. Can Fundus Fluorescein Angiography be Performed for Diabetic Patients on Oral Metformin?. Chin Med Sci J. 2017;32:119-2 pubmed publisher
    ..Therefore, the authors believe FFA is safe for diabetic patients with oral metformin and it is unnecessary to stop metformin before the examination...
  78. Vincent J. Drugs and the Kidneys: Clinical Pharmacology Perspectives. Clin Pharmacol Ther. 2017;102:368-372 pubmed publisher
    ..Kidney damage may be distinguished from changes in kidney function using biomarkers, as discussed in some detail in this issue...
  79. Matsushita K, Kwak L, Hyun N, Bessel M, Agarwal S, Loehr L, et al. Community burden and prognostic impact of reduced kidney function among patients hospitalized with acute decompensated heart failure: The Atherosclerosis Risk in Communities (ARIC) Study Community Surveillance. PLoS ONE. 2017;12:e0181373 pubmed publisher
    ..However, most previous reports were from a single hospital, limiting their generalizability. Also, contemporary data using new equation for estimated glomerular filtration rate (eGFR) are needed...
  80. Leão F, de Menezes Succi R, Machado D, Gouvêa A, do Carmo F, Beltrão S, et al. Renal abnormalities in a cohort of HIV-infected children and adolescents. Pediatr Nephrol. 2016;31:773-8 pubmed publisher
    ..73 m(2). The subclinical renal abnormalities found in this study may indicate early manifestations of a broad spectrum of renal dysfunction associated with HIV and involves the decision to initiate or modify ART. ..
  81. Zhou D, Liu Y. Renal fibrosis in 2015: Understanding the mechanisms of kidney fibrosis. Nat Rev Nephrol. 2016;12:68-70 pubmed publisher
  82. Papadimitriou J, Randhawa P, Rinaldo C, Drachenberg C, Alexiev B, Hirsch H. BK Polyomavirus Infection and Renourinary Tumorigenesis. Am J Transplant. 2016;16:398-406 pubmed publisher
  83. Sasaki K, Lahoti A, Jabbour E, Jain P, Pierce S, Borthakur G, et al. Clinical Safety and Efficacy of Nilotinib or Dasatinib in Patients With Newly Diagnosed Chronic-Phase Chronic Myelogenous Leukemia and Pre-Existing Liver and/or Renal Dysfunction. Clin Lymphoma Myeloma Leuk. 2016;16:152-62 pubmed publisher
    ..001). Patients with CML-CP and mild to moderate renal or liver dysfunction can be safely treated with front-line dasatinib or nilotinib and can achieve response rates similar to those of patients with CML-CP without organ dysfunction. ..
  84. Sakai K, Senda T, Hata R, Kuroda M, Hasegawa M, Kato M, et al. Patients that have Undergone Hemodialysis Exhibit Lower Amyloid Deposition in the Brain: Evidence Supporting a Therapeutic Strategy for Alzheimer's Disease by Removal of Blood Amyloid. J Alzheimers Dis. 2016;51:997-1002 pubmed publisher
    ..This significant difference was also confirmed by silver staining. Our findings suggest that removal of blood A? by hemodialysis results in lower accumulation of A? in the brain. ..
  85. Kim J, Lee Y, Lim B, Jeong H, Kim P, Shin J. Influence of cyclosporine A on glomerular growth and the effect of mizoribine and losartan on cyclosporine nephrotoxicity in young rats. Sci Rep. 2016;6:22374 pubmed publisher
  86. Holdsworth S, Gan P, Kitching A. Biologics for the treatment of autoimmune renal diseases. Nat Rev Nephrol. 2016;12:217-31 pubmed publisher
    ..The opportunities and challenges for the introduction of relevant biologics into treatment protocols for autoimmune renal diseases are also discussed. ..
  87. Elseweidy M, Zaghloul M, Younis N. 10-DHGD ameliorates cisplatin-induced nephrotoxicity in rats. Biomed Pharmacother. 2016;83:241-246 pubmed publisher
    ..10-DHGD exhibited a marked anti-inflammatory potential, alleviated to a great extent of nephrotoxicity and renal fibrosis induced by cisplatin. ..
  88. Neal B, Perkovic V, Mahaffey K, de Zeeuw D, Fulcher G, Erondu N, et al. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. N Engl J Med. 2017;377:644-657 pubmed publisher
    ..Funded by Janssen Research and Development; CANVAS and CANVAS-R ClinicalTrials.gov numbers, NCT01032629 and NCT01989754 , respectively.). ..
  89. Viau M, Renaud M, Gregoire J, Sebastianelli A, Plante M. Paraneoplastic syndromes associated with gynecological cancers: A systematic review. Gynecol Oncol. 2017;146:661-671 pubmed publisher
    ..As the mainstay of treatment in these conditions is often to address the underlying tumor, it is of upmost importance that physicians be aware of these rare cancer manifestations. ..
  90. Liang M, Yang S, Fu N. Efficacy of short-term moderate or high-dose rosuvastatin in preventing contrast-induced nephropathy: A meta-analysis of 15 randomized controlled trials. Medicine (Baltimore). 2017;96:e7384 pubmed publisher
    ..The aim of the study was to perform a meta-analysis of randomized controlled trials (RCTs) to assess the effectiveness of short-term moderate or high-dose rosuvastatin pretreatment in preventing CIN...
  91. Some F, Koech M, Chesire E, Kigen G. Reversal of tenofovir induced nephrotoxicity: case reports of two patients. Pan Afr Med J. 2017;27:126 pubmed publisher
    ..We report two clinical cases seen in our renal clinic with high creatinine levels suggestive of nephrotoxicity who reverted back to normality upon withdrawal of tenofovir...
  92. Futier E, Lefrant J, Guinot P, Godet T, Lorne E, Cuvillon P, et al. Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery: A Randomized Clinical Trial. JAMA. 2017;318:1346-1357 pubmed publisher
    ..Perioperative hypotension is associated with an increase in postoperative morbidity and mortality, but the appropriate management strategy remains uncertain...