multicystic dysplastic kidney


Summary: A nongenetic defect due to malformation of the KIDNEY which appears as a bunch of grapes with multiple renal cysts but lacking the normal renal bean shape, and the collection drainage system. This condition can be detected in-utero with ULTRASONOGRAPHY.

Top Publications

  1. Eckoldt F, Woderich R, Wolke S, Heling K, Stover B, Tennstedt C. Follow-up of unilateral multicystic kidney dysplasia after prenatal diagnosis. J Matern Fetal Neonatal Med. 2003;14:177-86 pubmed
    ..We analyze our own experience and demonstrate a management regime based on these results and existing studies...
  2. Aslam M, Watson A. Unilateral multicystic dysplastic kidney: long term outcomes. Arch Dis Child. 2006;91:820-3 pubmed
    To report the long term follow up of children with antenatally detected unilateral multicystic dysplastic kidney (MCDK) with documentation of complications, involution rate with time, and renal function at 10 years.
  3. Kaneyama K, Yamataka A, Lane G, Someya T, Yamashiro Y, Miyano T. Requirement for screening for vesicoureteric reflux in children with multicystic dysplastic kidney: some considerations based on our experience and literature review. J Pediatr. 2006;149:882-3; author reply 883-4 pubmed
  4. Schreuder M, Westland R, van Wijk J. Unilateral multicystic dysplastic kidney: a meta-analysis of observational studies on the incidence, associated urinary tract malformations and the contralateral kidney. Nephrol Dial Transplant. 2009;24:1810-8 pubmed publisher
    Many papers are published on cohorts with unilateral multicystic dysplastic kidney (MCDK) patients, but show variable results as to the incidence of associated urinary tract abnormalities...
  5. Deeb A, Robertson A, MacColl G, Bouloux P, Gibson M, Winyard P, et al. Multicystic dysplastic kidney and Kallmann's syndrome: a new association?. Nephrol Dial Transplant. 2001;16:1170-5 pubmed
  6. Belk R, Thomas D, Mueller R, Godbole P, Markham A, Weston M. A family study and the natural history of prenatally detected unilateral multicystic dysplastic kidney. J Urol. 2002;167:666-9 pubmed
    We document the inheritance pattern of multicystic dysplastic kidney in 3 affected families and screen first-degree relatives of a cohort of children with prenatally detected multicystic dysplastic kidney for renal anomalies...
  7. Miller D, Rumohr J, Dunn R, Bloom D, Park J. What is the fate of the refluxing contralateral kidney in children with multicystic dysplastic kidney?. J Urol. 2004;172:1630-4 pubmed
    We clarify the natural history of contralateral vesicoureteral reflux (VUR) in children with multicystic dysplastic kidney (MCDK), including its impact on long-term renal growth.
  8. Narchi H. Risk of Wilms' tumour with multicystic kidney disease: a systematic review. Arch Dis Child. 2005;90:147-9 pubmed
    ..With this risk still poorly defined and somewhat controversial, the strategy and the duration of follow up do not seem to be based on evidence...
  9. Welch T, Wacksman J. The changing approach to multicystic dysplastic kidney in children. J Pediatr. 2005;146:723-5 pubmed

More Information

Publications104 found, 100 shown here

  1. Ismaili K, Avni F, Alexander M, Schulman C, Collier F, Hall M. Routine voiding cystourethrography is of no value in neonates with unilateral multicystic dysplastic kidney. J Pediatr. 2005;146:759-63 pubmed
    ..two successive ultrasound examinations could rule out the presence of clinically significant contralateral anomalies in neonates with multicystic dysplastic kidney (MCDK), thereby avoiding unnecessary voiding cystourethrography (VCUG).
  2. Weber S, Moriniere V, Knüppel T, Charbit M, Dusek J, Ghiggeri G, et al. Prevalence of mutations in renal developmental genes in children with renal hypodysplasia: results of the ESCAPE study. J Am Soc Nephrol. 2006;17:2864-70 pubmed
    ..In conclusion, 15% of patients with RHD show mutations in TCF2 or PAX2, whereas abnormalities in EYA1, SALL1, and SIX1 are less frequent...
  3. Hains D, Bates C, Ingraham S, Schwaderer A. Management and etiology of the unilateral multicystic dysplastic kidney: a review. Pediatr Nephrol. 2009;24:233-41 pubmed publisher
    In children, unilateral multicystic dysplastic kidney (MCDK) is one of the most frequently identified urinary tract abnormalities. A variety of proposed etiologies has been associated with the underlying pathogenesis of MCDK...
  4. Arena S, Fazzari C, Scuderi M, Implatini A, Villari D, Torre S, et al. Molecular events involved in the morphogenesis of multicystic dysplastic kidney. Urol Int. 2010;85:106-11 pubmed publisher
    ..A relationship between the degree of cystogenesis and reduced E-cadherin (E-cad) expression was described. Syndecan-1 (Sdc-1) has a critical role in kidney development...
  5. Mansoor O, Chandar J, Rodriguez M, Abitbol C, Seeherunvong W, Freundlich M, et al. Long-term risk of chronic kidney disease in unilateral multicystic dysplastic kidney. Pediatr Nephrol. 2011;26:597-603 pubmed publisher
    The clinical spectrum of renal dysplasia includes the non-functioning multicystic dysplastic kidney (MCDK)...
  6. Konda R, Sato H, Ito S, Sakai K, Kimura N, Nagura H. Renin containing cells are present predominantly in scarred areas but not in dysplastic regions in multicystic dysplastic kidney. J Urol. 2001;166:1910-4 pubmed
    Hypertension is an important complication of multicystic dysplastic kidney and it has been suggested that it is induced by renin. Little information is available on renin production in this disease...
  7. Liapis H, Doshi R, Watson M, Liapis A, Steinhardt G. Reduced renin expression and altered gene transcript profiles in multicystic dysplastic kidneys. J Urol. 2002;168:1816-20; discussion 1820 pubmed
    ..Several other candidate genes whose altered expression may be associated with the pathophysiology of multicystic dysplasia provide intriguing molecular targets for future study. ..
  8. Alexiev B, Lin X, Sun C, Brenner D. Meckel-Gruber syndrome: pathologic manifestations, minimal diagnostic criteria, and differential diagnosis. Arch Pathol Lab Med. 2006;130:1236-8 pubmed
    ..In these cases, a meticulous autopsy is necessary to establish the diagnosis of Meckel-Gruber syndrome...
  9. Hussain S, Begum N. Multicystic dysplastic disease of kidney in fetus. J Ayub Med Coll Abbottabad. 2007;19:68-9 pubmed
    ..Diagnosis is facilitated by ultrasonography. Respiratory compromise on account of mass effect may need repeated percutaneous cyst aspiration. Nephrectomy is the definitive treatment option. ..
  10. Dimala C, Bechem N, Kadia B, Feteh V, Choukem S. Diagnostic and therapeutic challenges of an ambiguous cystic kidney disease in a resource limited setting: a case report. BMC Res Notes. 2017;10:114 pubmed publisher
    Unilateral renal cystic disease is a rare condition that shares morphological similarities with multicystic dysplastic kidney, the former often distinguished from the latter on some clinical and histopathological grounds...
  11. Abidari J, Park K, Kennedy W, Shortliffe L. Serial followup of the contralateral renal size in children with multicystic dysplastic kidney. J Urol. 2002;168:1821-5; discussion 1825 pubmed
    ..A parenchymal area growth curve was generated for the contralateral kidney in the multicystic dysplastic kidney group from birth to 216 months, and for right and left normal kidneys from birth to 338 months...
  12. Oueslati S, Louati H, Dhiab R, Kchaou S, Masmoudi A, Fkih C, et al. [Antenatal diagnosis of multicystic renal dysplsia. Report of 11 cases]. Tunis Med. 2007;85:389-92 pubmed
    ..In certain cases of non lethal anomalies, antenatal detection may influence both obstetric and postnatal management. Conservative management requires appropriate investigation of urinary tract tract and long-term follow-up. ..
  13. Narchi H. Risk of hypertension with multicystic kidney disease: a systematic review. Arch Dis Child. 2005;90:921-4 pubmed
    ..Large prospective cohort studies with a very long duration of follow up are needed. ..
  14. Fryer K, Nield L, Muchant D. Multicystic dysplastic kidney. Clin Pediatr (Phila). 2007;46:365-7 pubmed
  15. Kalisvaart J, Bootwala Y, Poonawala H, Elmore J, Kirsch A, Scherz H, et al. Comparison of ultrasound and magnetic resonance urography for evaluation of contralateral kidney in patients with multicystic dysplastic kidney disease. J Urol. 2011;186:1059-64 pubmed publisher
    The contralateral kidney is abnormal in up to 25% of patients with multicystic dysplastic kidney. Traditionally, anatomical and functional evaluation of the contralateral kidney has been performed with ultrasound and dimercapto-succinic ..
  16. Friedman M, Aguilar L, Heyward Q, Wheeler C, Caldamone A. Screening for Mullerian anomalies in patients with unilateral renal agenesis: Leveraging early detection to prevent complications. J Pediatr Urol. 2018;14:144-149 pubmed publisher and screening for Mullerian anomalies in patients with unilateral renal agenesis (URA) and multicystic dysplastic kidney (MCDK) to guide providers, patients, and parents on proper identification and management (Table)...
  17. Cortes D, Jørgensen T, Rittig S, Thaarup J, Hansen A, Andersen K, et al. [Prenatal diagnosed hydronephrosis and other urological anomalies]. Ugeskr Laeger. 2006;168:2544-50 pubmed
    ..This paper provides Danish guidelines for prenatal diagnosis, follow-up and intervention in cases of urological anomalies and guidelines for post-natal diagnosis, follow-up and treatment of these anomalies, especially hydronephrosis. ..
  18. Greenbaum L. Renal dysplasia and MRI: a clinician's perspective. Pediatr Radiol. 2008;38 Suppl 1:S70-5 pubmed
    ..The emphasis is on the important clinical issues, and the potential of MRI as a methodology for providing clinically useful information not otherwise available from other imaging modalities. ..
  19. Mattioli G, Pini Prato A, Costanzo S, Avanzini S, Rossi V, Basile A, et al. Nephrectomy for multicystic dysplastic kidney and renal hypodysplasia in children: where do we stand?. Pediatr Surg Int. 2010;26:523-8 pubmed publisher
    ..Forty procedures were performed. Twelve patients were preoperatively diagnosed of having multicystic dysplastic kidney (MCDK), which was confirmed in 10, whereas the remaining 28 patients of having severe dysplasia or ..
  20. Lazarus J. Exciting times: towards a totally minimally invasive paediatric urology service. S Afr J Surg. 2011;49:8-10, 12 pubmed
    ..This article reviews the literature related to laparoscopic dismembered pyeloplasty, optimising posterior urethral valve ablation and intravesical laparoscopic ureteric reimplantation. ..
  21. Tam Y, Pang K, Tsui S, Wong Y, Wong H, Mou J, et al. Laparoendoscopic single-site nephrectomy and heminephroureterectomy in children using standard laparoscopic setup versus conventional laparoscopy. Urology. 2013;82:430-5 pubmed publisher
    ..Further studies are required to investigate the implication of patient selection and the cosmetic benefits of LESS, which may potentially require longer operative time. ..
  22. Bayne C, Peters C. Congenital infundibulopelvic stenosis: Indications for intervention, surgical technique, and review of literature. J Pediatr Urol. 2016;12:389.e1-389.e5 pubmed publisher
    ..of a 16-year-old female had IFPS in a solitary kidney, with previous contralateral nephrectomy of a multicystic dysplastic kidney. The second case, a 17-year-old male, presented after blunt trauma to the ipsilateral flank...
  23. Bruechle N, Steuernagel P, Zerres K, Kurth I, Eggermann T, Knopp C. Uniparental disomy as an unexpected cause of Meckel-Gruber syndrome: report of a case. Pediatr Nephrol. 2017;: pubmed publisher
    ..Even if rare, awareness of UPD and comprehensive work-up in the case of unexpected homozygosity for a recessive mutation is essential for accurate genetic counseling and assessment of the risk of recurrence. ..
  24. Siqueira Rabelo E, Oliveira E, Silva J, Oliveira D, Colosimo E. Ultrasound progression of prenatally detected multicystic dysplastic kidney. Urology. 2006;68:1098-102 pubmed
    To evaluate the sonographic involution of prenatally detected multicystic dysplastic kidney (MCDK). A total of 53 children with unilateral MCDK detected by prenatal ultrasonography between 1989 and 2004 were included in this analysis...
  25. Takeuchi M, Kamishima Y, Hara M, Horibe Y, Ishii M, Okumura K, et al. Segmental multicystic dysplastic kidney in an adult: usefulness of enhanced CT in excretory phase. Abdom Imaging. 2013;38:603-7 pubmed publisher
    We present an adult case of segmental multicystic dysplastic kidney (SMCDK). The patient had a 10 × 6 cm oval-shaped mass consisting of a solid and multilocular cystic component at the right upper renal sinus...
  26. Xu J, Chen D, Mao Z, Huang H, Xu C, Wang C, et al. Autosomal dominant polycystic kidney disease with ectopic unilateral multicystic dysplastic kidney. BMC Nephrol. 2013;14:38 pubmed publisher
    ..The compensatory capacity in patients with ADPKD is fragile, and missing one kidney could accelerate the deterioration of renal function. ..
  27. Seeman T, John U, Blahova K, Vondrichova H, Janda J, Misselwitz J. Ambulatory blood pressure monitoring in children with unilateral multicystic dysplastic kidney. Eur J Pediatr. 2001;160:78-83 pubmed
    b>Multicystic dysplastic kidney (MCDK) is one of the most common congenital renal anomalies. Arterial hypertension is a potential complication of MCDK...
  28. Fujinaga S, Hirano D, Hara S, Uchida H, Kitano Y, Kobayashi K, et al. Seminal vesicle abscesses associated with ipsilateral multicystic dysplastic kidney in an infant. Pediatr Nephrol. 2008;23:1551-4 pubmed publisher
    ..We herein describe a 2-month-old boy with a left SVA and ipsilateral multicystic dysplastic kidney (MCDK) who presented with a recurrent urinary tract infection (UTI)...
  29. Kajbafzadeh A, Payabvash S, Sadeghi Z, Elmi A, Jamal A, Hantoshzadeh Z, et al. Comparison of magnetic resonance urography with ultrasound studies in detection of fetal urogenital anomalies. J Pediatr Urol. 2008;4:32-9 pubmed publisher vesicoureteral junction obstruction) in five, ureterocele in five, posterior urethral valve in 16, multicystic dysplastic kidney in six, mesenteric cyst in one and abdominoscrotal hydrocele in one...
  30. Iscaife A, Barbosa M, Ortiz V, Macedo A. Segmental multicystic dysplastic kidney: a rare situation. J Pediatr Urol. 2011;7:491-4 pubmed publisher
    Segmental multicystic dysplastic kidney is a rare subtype, found in only about 4% of children diagnosed with MCDK. To the best of our knowledge, we describe the 36th reported case of segmental multicystic kidney disease.
  31. Norwood V, Morham S, Smithies O. Postnatal development and progression of renal dysplasia in cyclooxygenase-2 null mice. Kidney Int. 2000;58:2291-300 pubmed
    ..Tissue-specific and time-dependent expression of COX-2 appears necessary for normal postnatal renal development and the maintenance of normal renal architecture and function. ..
  32. Pollio F, Sica C, Pacilio N, Maruotti G, Mazzarelli L, Cirillo P, et al. [Pentalogy of Cantrell: first trimester prenatal diagnosis and association with multicistic dysplastic kidney]. Minerva Ginecol. 2003;55:363-6 pubmed
    ..Our results confirm the possibility of an early detection of Cantrell's pentalogy and reveal the possibility of associations with other pathological findings. ..
  33. Pisani A, Riccio E, Cianciaruso B, Imbriaco M. Simultaneous multicystic kidney and Anderson-Fabry disease: 2 separate entities or same side of the coin. J Nephrol. 2011;24:806-8 pubmed publisher
    ..The alpha-galactosidase activity in his serum was low, and a final diagnosis of Anderson-Fabry disease with concomitant multicystic kidney was confirmed by genetic analysis. ..
  34. Suzuki K, Kurokawa S, Muraishi O, Tokue A. Segmental multicystic dysplastic kidney in an adult woman. Urol Int. 2001;66:51-4 pubmed
    We report a case of unilateral segmental multicystic dysplastic kidney (SMCDK) in an adult woman. A 42-year-old woman presented with abdominal distension and gross hematuria...
  35. Shaheen I, Watson A, Broderick N, Rance C. Multicystic dysplastic kidney and pelviureteric junction obstruction. Pediatr Surg Int. 2005;21:282-4 pubmed
    ..We suggest that it is good practice to review patients with antenatally detected urinary tract abnormalities and equivocal investigations at joint nephrouroradiology meetings. ..
  36. Fotso A, Aubert D, Saltoun K, Galli G, Bonneville J, Bracard S. Congenital paravertebral arteriovenous fistula: a case report. J Pediatr Surg. 2006;41:e21-3 pubmed
    ..We report 1 case with thoracic localization of a congenital paraspinal arteriovenous fistula associated with a multicystic kidney in a 3-year-old boy who was treated by endovascular embolization. ..
  37. Aguilar Ruiz A, Torramilans Lluis A, Castells Esteve M, Vargas Blasco C. [Cystic multilocular nephroma. Report of a case]. Actas Urol Esp. 2003;27:718-20 pubmed
    ..Multilocular cystic nephroma appears as a cystic disease, separately fibrous thin walls, with or without calcifications. We have to make a distinctive diagnosis between RCC and multilocular. Definitive diagnosis is always histological. ..
  38. Kim C, Bennett N, Docimo S. Missed testis on laparoscopy despite blind-ending vessels and closed processus vaginalis. Urology. 2005;65:1226 pubmed
    ..We present a case of an intra-abdominal testis that was missed on diagnostic laparoscopy. Despite a closed processus vaginalis, an absent vas deferens, and blind-ending vessels above the internal ring, the testis was missed. ..
  39. Woolf A. Unilateral multicystic dysplastic kidney. Kidney Int. 2006;69:190-3 pubmed
  40. Schreuder M. Unilateral anomalies of kidney development: why is left not right?. Kidney Int. 2011;80:740-5 pubmed publisher
    ..left side, a meta-analysis was performed on the distribution of five different unilateral anomalies: multicystic dysplastic kidney, renal agenesis/aplasia, renal ectopia, pelviureteral junction obstruction, and non-obstructive non-..
  41. Garg M, Singh V, Sinha R, Sankhwar S. Prospective randomized comparison of retroperitoneoscopic vs open pyeloplasty with minimal incision: subjective and objective assessment in adults. Urology. 2014;83:805-11 pubmed publisher
    ..To determine the subjective and objective outcomes of retroperitoneoscopic vs open pyeloplasty with minimal incision in a prospective randomized comparison study...
  42. Pop Trajković S, Ljubic A, Antić V, Trenkić M. [Association of fetal unilateral multicystic kidney disease with other urinary tract anomalies]. Vojnosanit Pregl. 2009;66:733-7 pubmed
    b>Multicystic dysplastic kidney represents a disorder in the fetus development presented prenatally of postnatally, this deserving special attention due to a risk of additional anomalies in children with this disorder...
  43. Kumar S, Walia S, Ikpeme O, Zhang E, Paramasivam G, Agarwal S, et al. Postnatal outcome of prenatally diagnosed severe fetal renal pelvic dilatation. Prenat Diagn. 2012;32:519-22 pubmed publisher
    ..An obstructive cause is usually present in severe cases, which are more likely to require surgery if there is PUJ obstruction. A high male:female ratio was present in this group. ..
  44. Singh I, Sharma D, Singh N, Jain B, Minocha V. Hydronephrotic obstructed kidney mimicking a congenital multicystic kidney: case report with review of literature. Int Urol Nephrol. 2002;34:179-82 pubmed did not reveal any such publication describing the differentiation of the hydronephrotic multicystic dysplastic kidney from the obstructed hydronephrotic kidney of pelviureteral obstruction...
  45. Al Ghwery S, Al Asmari A. Multicystic dysplastic kidney: conservative management and follow-up. Ren Fail. 2005;27:189-92 pubmed
    This study reports our experience in the conservative management of multicystic dysplastic kidney (MCDK) disease. Between 1992 and 2003, 35 children, 18 male (51.4%) and 17 female (48...
  46. Nef S, Neuhaus T, Spartà G, Weitz M, Buder K, Wisser J, et al. Outcome after prenatal diagnosis of congenital anomalies of the kidney and urinary tract. Eur J Pediatr. 2016;175:667-76 pubmed publisher
    ..5-10 mm; n = 25), and further diagnosis as primary obstructive megaureter, unilateral multicystic dysplastic kidney, renal dysplasia and posterior urethral valves...
  47. Acar B, Yalcinkaya F, Fitoz S, Ozcakar Z, Yuksel S, Soygur T, et al. Multicystic dysplastic kidney and caliceal diverticulum in a child a coincidence or an association?. Int Urol Nephrol. 2007;39:27-9 pubmed
  48. Shukla A, Kiddoo D, Kolon T, Canning D. The neonatal vanishing kidney: congenital and vascular etiologies. J Urol. 2004;172:317-8 pubmed
  49. Watanabe T, Yamazaki A, Kurabayashi T, Hanaoka J. Familial multicystic dysplastic kidney. Pediatr Nephrol. 2005;20:1200 pubmed
  50. Taylor C. Risk of hypertension in children with multicystic dysplastic kidney. Arch Dis Child. 2006;91:277-8; author reply 277-8 pubmed
  51. Mochizuki T, Fujita K, Yamada H, Ogata T. [HDR syndrome (GATA3 haploinsufficiency syndrome)]. Nihon Rinsho. 2006;Suppl 2:74-6 pubmed
  52. Prontera P, Sensi A, Pilu G, Baldi M, Baffico M, Bonasoni R, et al. FGFR3 mutation in thanatophoric dysplasia type 1 with bilateral cystic renal dysplasia: coincidence or a new association?. Genet Couns. 2006;17:407-12 pubmed
    ..CRD has not been previously described in TD or other conditions due to FGFR3 mutations, but occurs in Apert syndrome (due to FGFR2 mutations). The possible involvement of renal developmental defect in FGFR3 mutations is discussed...
  53. Hu W, He J, Shen Y, Cai S, Lu H. [Ultrasonic diagnosis and prognosis of fetal multicystic kidney dysplasia]. Zhonghua Yi Xue Za Zhi. 2007;87:1491-2 pubmed
    ..To explore the diagnosis, clinical course and prognosis of fetal multicystic kidney dysplasia (MCDK)...
  54. Guertl B, Senanayake U, Nusshold E, Leuschner I, Mannweiler S, Ebner B, et al. Lim1, an embryonal transcription factor, is absent in multicystic renal dysplasia, but reactivated in nephroblastomas. Pathobiology. 2011;78:210-9 pubmed publisher
    ..Lim1 (Lim homeobox 1) plays an important role during rodent renal development; however, its rolein human kidney development and disease is still unclear...
  55. Malaki M, Nemati M, Shoaran M. Joubert syndrome presenting as unilateral dysplastic kidney, hypotonia, and respiratory problem. Saudi J Kidney Dis Transpl. 2012;23:325-9 pubmed
    ..month of age with the diagnosis of kidney infection and it was revealed that she had a unilateral multicystic dysplastic kidney. In recent admission, she presented to emergency room with fever, hyperpnea, and apnea...
  56. Matsumoto F, Shimada K, Hosokawa S, Johnin K. [Outcome of neonates born with unilateral multicystic dysplastic kidneys]. Nihon Hinyokika Gakkai Zasshi. 2001;92:615-8 pubmed
    ..To review our experience of neonates with unilateral multicystic dysplastic kidneys (MCDKs) and to plan how to manage this anomaly...
  57. Sarmiento de la Iglesia M, Pena B, Lecumberri G, Oleaga L, Grande Icaran D. [Segmental multicystic renal dysplasia: radiological findings and differential diagnosis]. Radiologia. 2007;49:269-71 pubmed
  58. Cambio A, Evans C, Kurzrock E. Non-surgical management of multicystic dysplastic kidney. BJU Int. 2008;101:804-8 pubmed publisher
    To better define the outcome and association of multicystic dysplastic kidney (MCDK) with hypertension, vesico-ureteric reflux (VUR), infection and cancer, as there is no consensus on the management of patients born with MCDK...
  59. Patkowski D, Apoznanski W, Szydełko T, Jaworski W, Smigiel R. Bladder agenesis in a male neonate. J Pediatr Surg. 2008;43:e1-3 pubmed publisher
    ..This is a case report of a male patient with several congenital anomalies including penoscrotal transposition, severe kidney's dysplasia, and agenesis of the bladder. The patient lived for 4 months and died because of severe pneumonia...
  60. Tonni G, Azzoni D, Ventura A, Ambrosetti F, De Felice C. "Multicystic dysplastic kidney (Potter type II syndrome) and agenesis of corpus callosum (ACC) in two consecutive pregnancies: a possible teratogenic effect of electromagnetic exposure in utero". Fetal Pediatr Pathol. 2008;27:264-73 pubmed publisher
    ..A case of fetal multicystic dysplastic kidney disease (Potter type II syndrome) and complete agenesis of the corpus callosum demonstrated by the ..
  61. Grattan Smith J, Jones R, Little S, Kirsch A. Bilateral congenital midureteric strictures associated with multicystic dysplastic kidney and hydronephrosis: evaluation with MR urography. Pediatr Radiol. 2011;41:117-20 pubmed publisher
    ..The severity of obstruction differed in the two ureters, resulting in a multicystic dysplastic kidney (MCDK) with an atretic ureter on one side and hydronephrosis that worsened over time due to ..
  62. Singh P, Dogra P, Kumar R, Gupta N, Nayak B, Seth A. Outcomes of robot-assisted laparoscopic pyeloplasty in children: a single center experience. J Endourol. 2012;26:249-53 pubmed publisher
    ..There is sparse data over the outcomes of robot-assisted laparoscopic pyeloplasties in children. We describe our technique and outcomes of robotic pyeloplasty in children...
  63. Cleper R. Mechanisms of compensatory renal growth. Pediatr Endocrinol Rev. 2012;10:152-63 pubmed
    Congenitally reduced renal mass- as with agenesis of one kidney, unilateral multicystic dysplastic kidney or with premature birth with early arrest of nephrogenesis- as well as acquired loss of a significant part of kidney tissue- as ..
  64. Ranke A, Schmitt M, Didier F, Droulle P. Antenatal diagnosis of Multicystic Renal Dysplasia. Eur J Pediatr Surg. 2001;11:246-54 pubmed
    ..We advise complete neonatal urological investigation, and surgical removal of multicystic kidneys, to avoid multiple and inadequate evaluations of those children with a single functioning renal unit...
  65. Mathiot A, Liard A, Eurin D, Dacher J. [Prenatally detected multicystic renal dysplasia and associated anomalies of the genito-urinary tract]. J Radiol. 2002;83:731-5 pubmed
    To analyze the prevalence of genitourinary malformations associated with multicystic dysplastic kidney (MCDK).
  66. Tomimatsu T, Fukuda H, Kanzaki T, Hirano S, Wada K, Murata Y. Neonatal Bartter syndrome with unilateral multicystic dysplastic kidney disease. Pediatr Nephrol. 2003;18:391-3 pubmed
    ..In this paper, we report a case of neonatal Bartter syndrome associated with unilateral multicystic dysplastic kidney disease. To our knowledge, this is the first case report of such an association.
  67. Carmack A, Castellan M, Perez Brayfield M, Gosalbez R. Segmental multicystic dysplasia and ureteropelvic junction obstruction in a nonduplicated kidney. J Pediatr Surg. 2006;41:e1-3 pubmed
    ..The rare diagnosis of a segmental multicystic dysplastic kidney with ipsilateral ureteropelvic junction obstruction was made...
  68. Park K, McHugh K, vant Hoff W. Diagnosis of aortic coarctation by tardus-parvus renal artery Doppler signal in an infant with multicystic dysplastic kidney: a case report. Pediatr Radiol. 2007;37:310-2 pubmed
    We report an infant with known unilateral multicystic dysplastic kidney (MCDK) who underwent renal ultrasonography and Doppler spectral waveform analysis for investigation of hypertension...
  69. Weinstein A, Goodman T, Iragorri S. Simple multicystic dysplastic kidney disease: end points for subspecialty follow-up. Pediatr Nephrol. 2008;23:111-6 pubmed
    Simple multicystic dysplastic kidney (MCDK) disease, defined as unilateral MCDK without other genitourinary tract involvement, portends an excellent prognosis. Nevertheless, its long-term management remains undefined...
  70. Abdulhannan P, Stahlschmidt J, Subramaniam R. Multicystic dysplastic kidney disease and hypertension: clinical and pathological correlation. J Pediatr Urol. 2011;7:566-8 pubmed publisher
    ..We looked at the pathological correlation with respect to the hypertension caused by a non-functioning kidney...
  71. Yurtcu M, Baba Z. The effect of natrium hyaluronate applied locally for pelviureteral anastomoses. Ren Fail. 2013;35:138-42 pubmed publisher
    ..This study aimed to investigate the effect of natrium hyaluronate (NH) on fibrous tissue formation and wound healing in experimental pelviureteral anastomosis (PUA)...
  72. Winyard P, Chitty L. Dysplastic and polycystic kidneys: diagnosis, associations and management. Prenat Diagn. 2001;21:924-35 pubmed
    ..In this review we will attempt to describe the embryology and aetiology of these conditions and suggest an approach to management...
  73. Perera Soler R, Ruiz González A, Molini Menchón N, García Nieto V. [Unilateral multicystic dysplastic kidney and contralateral megacalycosis. An unusual association]. An Pediatr (Barc). 2004;60:473-6 pubmed
    ..We present a case of coexistence of a unilateral multicystic dysplastic kidney and contralateral megacalycosis associated with ipsilateral distal segmental megaureter...
  74. Kelm Kahl I, Beetz R. [Abnormalities of the urogenital tract and therapeutic results: children with solitary kidney with vesicoureteral reflux and ureteral stenosis]. Aktuelle Urol. 2004;35:350-4 pubmed
  75. Tan T, Nazaretian S, McGillivray G, Simpson I, Bankier A. Distinctive collection of fetal anomalies: cleft lip and palate, multicystic dysplastic kidneys, 1-2 syndactyly, heterotopic olivary tissue and thymic hypoplasia. Clin Dysmorphol. 2006;15:101-5 pubmed
    ..Differential diagnoses are discussed...
  76. Singh S, Gupta R, Nigam S, Khurana N, Aggarwal S, Chaturvedi K, et al. Clinico-pathological profile of 22 cases of cystic renal dysplasia. Indian J Pathol Microbiol. 2007;50:6-10 pubmed
    ..Cartilage may not be seen in all cases of renal dysplasia. Once diagnosed, other associated anomalies should also be looked for...
  77. Kumari N, Pradhan M, Shankar V, Krishnani N, Phadke S. Post-mortem examination of prenatally diagnosed fatal renal malformation. J Perinatol. 2008;28:736-42 pubmed publisher
    ..Fetal autopsy including histopathological examination of kidney is important to arrive at definite diagnosis. The objective was to assess importance of fetal autopsy and histopathology...
  78. Moses K, Scherz H. Partial ureteral quadruplication with contralateral multicystic dysplastic kidney. Urology. 2010;76:461-2 pubmed publisher
    ..Few cases have been reported worldwide, the majority being described in children. We report the first known case associated with contralateral multicystic dysplastic kidney.
  79. Neulander E, Katz T, Kaneti J. Upper pole multicystic dysplasia and ureteropelvic junction obstruction associated with obstructive-refluxing megaureter in a neonate with a single kidney. Can J Urol. 2010;17:5472-4 pubmed
    ..Second, when the child was older, we performed ureterovesical reimplantation with ureteral tailoring. Currently, after 5 years of follow up, the patient has stable renal function...
  80. Peco Antic A, Paripovic D, Kotur Stevuljevic J, Stefanovic A, Sćekić G, Milosevski Lomić G. Renal functional reserve in children with apparently normal congenital solitary functioning kidney. Clin Biochem. 2012;45:1173-7 pubmed publisher
    ..The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK)...
  81. Kis E, Verebely T, Várkonyi I, Máttyus I. [Multicystic dysplastic kidney: natural history of the affected and the contralateral kidney compared to the normal and solitary kidney]. Orv Hetil. 2002;143:19-23 pubmed
    Complications of multicystic dysplastic kidney are rare, but hypertension and malignant transformation represent real danger.
  82. van Eijk L, Cohen Overbeek T, Den Hollander N, Nijman J, Wladimiroff J. Unilateral multicystic dysplastic kidney: a combined pre- and postnatal assessment. Ultrasound Obstet Gynecol. 2002;19:180-3 pubmed
    To review the prenatal assessment of associated renal pathology, non-renal pathology and renal biometry, fetal outcome and postnatal urological management in the presence of unilateral fetal multicystic dysplastic kidney.
  83. Holder Espinasse M, Ahmad Z, Hamill J, Pahari A, Misra D, Drake D, et al. Familial syndromic duodenal atresia: Feingold syndrome. Eur J Pediatr Surg. 2004;14:112-6 pubmed
    ..We report a father and two sons with Feingold syndrome. One has bilateral dysplastic kidneys which have not been reported previously...
  84. Rabelo E, Oliveira E, Diniz J, Silva J, Filgueiras M, Pezzuti I, et al. Natural history of multicystic kidney conservatively managed: a prospective study. Pediatr Nephrol. 2004;19:1102-7 pubmed
    ..In conclusion, the natural history of MCDK is usually benign but patients must have long-term follow-up with US scans and blood pressure measurements...
  85. Hahn H, Ku S, Kim K, Park Y, Yoon C, Cheong H. Implication of genetic variations in congenital obstructive nephropathy. Pediatr Nephrol. 2005;20:1541-4 pubmed
    ..of the AGTR2 and other RAS genes in Korean patients with ureteropelvic junction obstruction, multicystic dysplastic kidney (MCDK), and unilateral renal agenesis (RA)...
  86. Prasun P, Pradhan M, Kumari N, Das V. Left-sided gastroschisis and bilateral multicystic dysplastic kidneys: a rare combination of anomalies. Prenat Diagn. 2007;27:872-3 pubmed
    ..It is now viewed as a malformation rather than disruption. The findings in this case support this view. The combination of dysplastic kidneys with ventral body wall defect suggests an early developmental defect...
  87. Winyard P, Chitty L. Dysplastic kidneys. Semin Fetal Neonatal Med. 2008;13:142-51 pubmed
    ..Effective genetic screening in future may require gene chip or other techniques to assess multiple genes concurrently, but this should not replace a multidisciplinary approach to these often difficult cases...
  88. Hasui M, Kaneko K, Tsuji S, Isozaki Y, Kimata T, Nozu Y, et al. Different phenotypes of HNF1ß deletion mutants in familial multicystic dysplastic kidneys. Clin Nephrol. 2013;79:484-7 pubmed
    b>Multicystic dysplastic kidney (MCDK) is one of the most common congenital abnormalities of the kidney and urinary tract (CAKUT), although its pathophysiology remains unknown...
  89. Ibrahim A, Aliyu S, Ali N. Bilateral pelvi-ureteric junction obstruction: our experience in a developing country. Niger J Clin Pract. 2014;17:267-9 pubmed publisher
    ..Recent advances have led to its diagnosis and management in the perinatal period. However, open surgery is still the mainstay of treatment in less endowed nations where late presentation is the norm...
  90. Agrawal L, Millard M, Fairhurst J, Gilbert R. Bilateral multicystic kidneys--an unusual case. Pediatr Nephrol. 2002;17:964-5 pubmed
    ..The patient had normal renal function and, following conservative management, remains alive and well 6 months later...
  91. Wilson B, Davies P, Shah K, Wong W, Taylor C. Renal length and inulin clearance in the radiologically normal single kidney. Pediatr Nephrol. 2003;18:1147-51 pubmed
    ..Provided that the nephron number in the single kidney is similar to that in a paired kidney, single kidneys are hypertrophied and the single nephron glomerular filtration rate is likely to be abnormally high in these children...
  92. Eckoldt F, Woderich R, Smith R, Heling K. Antenatal diagnostic aspects of unilateral multicystic kidney dysplasia--sensitivity, specificity, predictive values, differential diagnoses, associated malformations and consequences. Fetal Diagn Ther. 2004;19:163-9 pubmed
    ..Whilst an isolated unilateral MCKD has a good prognosis, a poor outcome must be expected when MCKD is associated with other complex abnormalities...