menorrhagia

Summary

Summary: Excessive uterine bleeding during MENSTRUATION.

Top Publications

  1. Sanghera S, Frew E, Kai J, Gupta J, Elizabeth Roberts T. An assessment of economic measures used in menorrhagia: a systematic review. Soc Sci Med. 2013;98:149-53 pubmed publisher
    b>Menorrhagia', or heavy menstrual bleeding, is a common problem affecting women...
  2. Ganz M, Shah D, Gidwani R, Filonenko A, Su W, Pocoski J, et al. The cost-effectiveness of the levonorgestrel-releasing intrauterine system for the treatment of idiopathic heavy menstrual bleeding in the United States. Value Health. 2013;16:325-33 pubmed publisher
    ..Our objective was to evaluate the cost-effectiveness of the levonorgestrel-releasing intrauterine system (LNG-IUS) compared with other therapies for idiopathic heavy menstrual bleeding...
  3. Hazard D, Harkins G. Patient satisfaction with thermal balloon ablation for treatment of menorrhagia. Am J Obstet Gynecol. 2009;200:e21-3 pubmed publisher
    ..of this study was to determine whether satisfaction in women who have undergone the thermal balloon ablation (TBA) procedure for menorrhagia at the Penn State Milton S. Hershey Medical Center is consistent with initial published studies.
  4. Theodoridis T, Zepiridis L, Zafrakas M, Grimbizis G, Tantsis A, Kyrou D, et al. Levonorgestrel-releasing intrauterine system vs. endometrial thermal ablation for menorrhagia. Hormones (Athens). 2009;8:60-4 pubmed
    To evaluate the efficacy of a Levonorgestrel-releasing Intrauterine System (LNG-IUS) in controlling menorrhagia in comparison with endometrial thermal rollerball ablation...
  5. Shaaban M, Shabaan M, Zakherah M, El Nashar S, Sayed G. Levonorgestrel-releasing intrauterine system compared to low dose combined oral contraceptive pills for idiopathic menorrhagia: a randomized clinical trial. Contraception. 2011;83:48-54 pubmed publisher
    This study compared the efficacy of the levonorgestrel-releasing intrauterine system (LNG-IUS) to low dose combined oral contraceptive pills (COC) in the management of idiopathic menorrhagia.
  6. Endrikat J, Shapiro H, Lukkari Lax E, Kunz M, Schmidt W, Fortier M. A Canadian, multicentre study comparing the efficacy of a levonorgestrel-releasing intrauterine system to an oral contraceptive in women with idiopathic menorrhagia. J Obstet Gynaecol Can. 2009;31:340-347 pubmed publisher
    ..intrauterine system (LNG-IUS) compared with a combined oral contraceptive containing 1 mg norethindrone acetate and 20 mg ethinyl estradiol (OC1/20) in reducing menstrual blood loss (MBL) in women with idiopathic menorrhagia.
  7. Kilonzo M, Sambrook A, Cook J, Campbell M, Cooper K. A cost-utility analysis of microwave endometrial ablation versus thermal balloon endometrial ablation. Value Health. 2010;13:528-34 pubmed publisher
    ..To evaluate the cost-effectiveness of microwave endometrial ablation (MEA) and thermal balloon endometrial ablation (TBALL) for heavy menstrual bleeding...
  8. Middleton L, Champaneria R, Daniels J, Hilken N, O Donovan P, Gray R, et al. Hysterectomy, endometrial destruction, and levonorgestrel releasing intrauterine system (Mirena) for heavy menstrual bleeding: systematic review and meta-analysis of data from individual patients. BMJ. 2010;341:c3929 pubmed publisher
  9. Sundstrom A, Seaman H, Kieler H, Alfredsson L. The risk of venous thromboembolism associated with the use of tranexamic acid and other drugs used to treat menorrhagia: a case-control study using the General Practice Research Database. BJOG. 2009;116:91-7 pubmed publisher
    ..To assess whether use of tranexamic acid is associated with an increased risk of venous thromboembolism (VTE)...

More Information

Publications72

  1. Lucot J, Coulon C, Collinet P, Cosson M, Vinatier D. [Surgical therapeutic management for menorrhagia]. J Gynecol Obstet Biol Reprod (Paris). 2008;37 Suppl 8:S398-404 pubmed publisher
    ..The possibility of further surgery should however be discussed pre-operatively. In case of hysterectomy, abdominal route is not recommended, and vaginal or laparoscopic routes are preferred...
  2. El Nashar S, Hopkins M, Barnes S, Pruthi R, Gebhart J, Cliby W, et al. Health-related quality of life and patient satisfaction after global endometrial ablation for menorrhagia in women with bleeding disorders: a follow-up survey and systematic review. Am J Obstet Gynecol. 2010;202:348.e1-7 pubmed publisher
    ..The purpose of this study was to describe health-related quality of life and satisfaction after global endometrial ablation in women with bleeding disorders and a systematic review of the literature...
  3. Sambrook A, Jack S, Cooper K. Outpatient microwave endometrial ablation: 5-year follow-up of a randomised controlled trial without endometrial preparation versus standard day surgery with endometrial preparation. BJOG. 2010;117:493-6 pubmed publisher
    ..It can be concluded that microwave endometrial ablation outcomes are not affected in the long term by undertaking the procedure in the postmenstrual phase in an outpatient setting...
  4. Miller C, Philipp C, Stein S, Kouides P, Lukes A, Heit J, et al. The spectrum of haemostatic characteristics of women with unexplained menorrhagia. Haemophilia. 2011;17:e223-9 pubmed publisher
    While an estimated 13% of women with unexplained menorrhagia have von Willebrand disease (VWD), the frequency of other potential bleeding disorders has been uncertain...
  5. Gupta J, Kai J, Middleton L, Pattison H, Gray R, Daniels J. Levonorgestrel intrauterine system versus medical therapy for menorrhagia. N Engl J Med. 2013;368:128-37 pubmed publisher
    b>Menorrhagia is a common problem, yet evidence to inform decisions about therapy is limited...
  6. Kroft J, Liu G. First- versus second-generation endometrial ablation devices for treatment of menorrhagia: a systematic review, meta-analysis and appraisal of economic evaluations. J Obstet Gynaecol Can. 2013;35:1010-1019 pubmed publisher
    ..of using second-generation endometrial ablation devices compared to first-generation devices for treatment of menorrhagia in pre-menopausal women. The secondary objective was to compare the second-generation devices with one another.
  7. Sambrook A, Cooper K, Campbell M, Cook J. Clinical outcomes from a randomised comparison of Microwave Endometrial Ablation with Thermal Balloon endometrial ablation for the treatment of heavy menstrual bleeding. BJOG. 2009;116:1038-45 pubmed publisher
    ..To compare the clinical outcomes of microwave endometrial ablation and thermal balloon ablation for the treatment of heavy menstrual bleeding...
  8. Penninx J, Mol B, Engels R, van Rumste M, Kleijn C, Koks C, et al. Bipolar radiofrequency endometrial ablation compared with hydrothermablation for dysfunctional uterine bleeding: a randomized controlled trial. Obstet Gynecol. 2010;116:819-26 pubmed publisher
    To compare the effectiveness of two second-generation ablation techniques, bipolar radiofrequency impedance-controlled endometrial ablation and hydrothermablation, in the treatment of menorrhagia.
  9. Bagaria M, Suneja A, Vaid N, Guleria K, Mishra K. Low-dose mifepristone in treatment of uterine leiomyoma: a randomised double-blind placebo-controlled clinical trial. Aust N Z J Obstet Gynaecol. 2009;49:77-83 pubmed publisher
    ..To evaluate the effect of low-dose mifepristone on leiomyoma-related symptoms, uterine and leiomyoma in women with symptomatic leiomyomata...
  10. Clark T, Samuel N, Malick S, Middleton L, Daniels J, Gupta J. Bipolar radiofrequency compared with thermal balloon endometrial ablation in the office: a randomized controlled trial. Obstet Gynecol. 2011;117:109-18 pubmed publisher
  11. Donnez J, Tatarchuk T, Bouchard P, Puscasiu L, Zakharenko N, Ivanova T, et al. Ulipristal acetate versus placebo for fibroid treatment before surgery. N Engl J Med. 2012;366:409-20 pubmed publisher
    ..The efficacy and safety of oral ulipristal acetate for the treatment of symptomatic uterine fibroids before surgery are uncertain...
  12. Garside R, Britten N, Stein K. The experience of heavy menstrual bleeding: a systematic review and meta-ethnography of qualitative studies. J Adv Nurs. 2008;63:550-62 pubmed publisher
    ..This paper is a report of a systematic review and meta-ethnography of the experience of heavy menstrual bleeding...
  13. Morrison J, Patel S, Watson W, Zaidi Q, Mangione A, Goss T. Assessment of the prevalence and impact of anemia on women hospitalized for gynecologic conditions associated with heavy uterine bleeding. J Reprod Med. 2008;53:323-30 pubmed
    ..This study was conducted to estimate the prevalence and impact of anemia in women hospitalized for gynecologic conditions associated with heavy uterine bleeding...
  14. Lukes A, Moore K, Muse K, Gersten J, Hecht B, Edlund M, et al. Tranexamic acid treatment for heavy menstrual bleeding: a randomized controlled trial. Obstet Gynecol. 2010;116:865-75 pubmed publisher
    ..To assess the efficacy and safety of an oral formulation of tranexamic acid for the treatment of heavy menstrual bleeding...
  15. El Mazny A, Abou Salem N, Elshenoufy H. Three-dimensional power Doppler study of endometrial and subendometrial microvascularization in women with intrauterine device-induced menorrhagia. Fertil Steril. 2013;99:1912-5 pubmed publisher
    ..microvascularization, using three-dimensional (3D) power Doppler ultrasound, in women with intrauterine device (IUD)-induced menorrhagia; and whether those potential findings could predict the risk of bleeding before IUD insertion.
  16. Akay O, Akin E, Mutlu F, Gulbas Z. Effect of Iron Therapy on Platelet Function among Iron-Deficient Women with Unexplained Menorrhagia. Pathophysiol Haemost Thromb. 2008;36:80-3 pubmed publisher
    ..This study was performed to evaluate the effect of iron therapy on platelet function among women with unexplained menorrhagia in order to better understand possible interactions between iron deficiency anemia and platelet behavior and ..
  17. Marret H, Fauconnier A, Chabbert Buffet N, Cravello L, Golfier F, Gondry J, et al. Clinical practice guidelines on menorrhagia: management of abnormal uterine bleeding before menopause. Eur J Obstet Gynecol Reprod Biol. 2010;152:133-7 pubmed publisher
    Normal menstrual periods last 3-6 days and involve blood loss of up to 80ml. Menorrhagia is defined as menstrual periods lasting more than 7 days and/or involving blood loss greater than 80ml...
  18. Daniels J, Middleton L, Champaneria R, Khan K, Cooper K, Mol B, et al. Second generation endometrial ablation techniques for heavy menstrual bleeding: network meta-analysis. BMJ. 2012;344:e2564 pubmed publisher
    ..To determine the relative effectiveness of second generation ablation techniques in the treatment of heavy menstrual bleeding...
  19. Chi C, Pollard D, Tuddenham E, Kadir R. Menorrhagia in adolescents with inherited bleeding disorders. J Pediatr Adolesc Gynecol. 2010;23:215-22 pubmed publisher
    We reviewed the management and treatment outcomes of menorrhagia in adolescents with inherited bleeding disorders and assessed the impact of menorrhagia on their quality of life.
  20. Kim Y, Chung H, Kang S, Kim S, Kim Y. Safety and usefulness of intravenous iron sucrose in the management of preoperative anemia in patients with menorrhagia: a phase IV, open-label, prospective, randomized study. Acta Haematol. 2009;121:37-41 pubmed publisher
    ..safety and achievement of the target hemoglobin level (Hb >or=10 g/dl) in patients with preoperative anemia due to menorrhagia who received intravenous iron sucrose compared with oral iron protein succinylate for anemia management.
  21. Sayed G, Zakherah M, El Nashar S, Shaaban M. A randomized clinical trial of a levonorgestrel-releasing intrauterine system and a low-dose combined oral contraceptive for fibroid-related menorrhagia. Int J Gynaecol Obstet. 2011;112:126-30 pubmed publisher
    To compare the efficacy of a levonorgestrel-releasing intrauterine system (LNG-IUS) with that of a low-dose combined oral contraceptive (COC) in reducing fibroid-related menorrhagia.
  22. Zakherah M, Sayed G, El Nashar S, Shaaban M. Pictorial blood loss assessment chart in the evaluation of heavy menstrual bleeding: diagnostic accuracy compared to alkaline hematin. Gynecol Obstet Invest. 2011;71:281-4 pubmed publisher
    ..The pictorial blood assessment chart (PBAC) is a method for evaluation of menstrual blood loss (MBL). This study was conducted to evaluate the accuracy of the PBAC score in diagnosing MBL compared to alkaline hematin as a gold standard...
  23. Kaunitz A, Bissonnette F, Monteiro I, Lukkari Lax E, Muysers C, Jensen J. Levonorgestrel-releasing intrauterine system or medroxyprogesterone for heavy menstrual bleeding: a randomized controlled trial. Obstet Gynecol. 2010;116:625-32 pubmed publisher
    ..To compare the efficacy and safety of the levonorgestrel-releasing intrauterine system and oral medroxyprogesterone acetate in the treatment of idiopathic heavy menstrual bleeding...
  24. Philipp C, Faiz A, Heit J, Kouides P, Lukes A, Stein S, et al. Evaluation of a screening tool for bleeding disorders in a US multisite cohort of women with menorrhagia. Am J Obstet Gynecol. 2011;204:209.e1-7 pubmed publisher
    ..the usefulness of a simple screening tool for bleeding disorders in a multisite population of women with menorrhagia. Women with menorrhagia between the ages of 18 and 50 years from 6 geographically diverse US centers underwent ..
  25. Duckitt K. Managing perimenopausal menorrhagia. Maturitas. 2010;66:251-6 pubmed publisher
    b>Menorrhagia is a significant health problem for many women. It increases with age and peaks during the perimenopause...
  26. El Nashar S, Hopkins M, Creedon D, Cliby W, Famuyide A. Efficacy of bipolar radiofrequency endometrial ablation vs thermal balloon ablation for management of menorrhagia: A population-based cohort. J Minim Invasive Gynecol. 2009;16:692-9 pubmed publisher
    ..To compare the efficacy of bipolar radiofrequency ablation (RFA) and thermal balloon ablation (TBA) using treatment failure and postprocedure amenorrhea as outcome measures...
  27. Cromwell D, Mahmood T, Templeton A, Van Der Meulen J. Surgery for menorrhagia within English regions: variation in rates of endometrial ablation and hysterectomy. BJOG. 2009;116:1373-9 pubmed publisher
    To examine variation between English regions in the use of surgery (endometrial ablation or hysterectomy) for the treatment of menorrhagia.
  28. Mariani G, Bernardi F. Factor VII Deficiency. Semin Thromb Hemost. 2009;35:400-6 pubmed publisher
    ..In females, menorrhagia is prevalent and affects two thirds of the patients of fertile age...
  29. Kaunitz A, Meredith S, Inki P, Kubba A, Sanchez Ramos L. Levonorgestrel-releasing intrauterine system and endometrial ablation in heavy menstrual bleeding: a systematic review and meta-analysis. Obstet Gynecol. 2009;113:1104-16 pubmed publisher
    ..To compare the effects of the levonorgestrel intrauterine system and endometrial ablation in reducing heavy menstrual bleeding...
  30. Kaunitz A, Inki P. The levonorgestrel-releasing intrauterine system in heavy menstrual bleeding: a benefit-risk review. Drugs. 2012;72:193-215 pubmed publisher
    ..In conclusion, the LNG-IUS is an effective treatment option for women with HMB, including those with underlying organic pathology or bleeding disorders...
  31. Esteve J, Acosta R, Pérez Y, Campos R, Hernández A, Texidó C. Treatment of uterine myoma with 5 or 10mg mifepristone daily during 6 months, post-treatment evolution over 12 months: double-blind randomised clinical trial. Eur J Obstet Gynecol Reprod Biol. 2012;161:202-8 pubmed publisher
    ..To evaluate the efficacy and safety of 5 and 10mg doses of mifepristone for 6 months for the treatment of uterine fibroids and to check those results at 1 year post-treatment...
  32. Chattopdhyay B, Nigam A, Goswami S, Chakravarty P. Clinical outcome of levonorgestrel intra-uterine system in idiopathic menorrhagia. Eur Rev Med Pharmacol Sci. 2011;15:764-8 pubmed
    To evaluate the efficacy, acceptability and side effects of levonorgestrel intrauterine system in patients with idiopathic menorrhagia.
  33. Mints M, Blomgren B, Palmblad J. Expression of angiopoietins 1, 2 and their common receptor tie-2 in relation to the size of endothelial lining gaps and expression of VEGF and VEGF receptors in idiopathic menorrhagia. Fertil Steril. 2010;94:701-7 pubmed publisher
    To investigate whether idiopathic menorrhagia (IM) is associated with alterations of the vascular expression of angiopoietin-1, angiopoietin-2, and tie-2 receptor.
  34. Frishman G. Evaluation and treatment of menorrhagia in an adolescent population. J Minim Invasive Gynecol. 2008;15:682-8 pubmed publisher
    ..Adolescents present with unique issues related to their age, involvement of family members, different differential diagnosis when compared to an older populations, and challenges associated with their evaluation and treatment...
  35. Hossain N, Farzana T, Khan N, Shamsi T, James A. Adolescent menorrhagia due to platelet function disorder. J Pak Med Assoc. 2010;60:127-9 pubmed
    The prevalence of menorrhagia in adolescent populations with bleeding disorders varies between 14% to 48%...
  36. Jensen J, Parke S, Mellinger U, Machlitt A, Fraser I. Effective treatment of heavy menstrual bleeding with estradiol valerate and dienogest: a randomized controlled trial. Obstet Gynecol. 2011;117:777-87 pubmed publisher
  37. Kouides P, Byams V, Philipp C, Stein S, Heit J, Lukes A, et al. Multisite management study of menorrhagia with abnormal laboratory haemostasis: a prospective crossover study of intranasal desmopressin and oral tranexamic acid. Br J Haematol. 2009;145:212-20 pubmed publisher
    The optimal management of menorrhagia among women with abnormal laboratory haemostasis is uncertain...
  38. Tasci Y, Caglar G, Kayikcioglu F, Cengiz H, Yagci B, Gunes M. Treatment of menorrhagia with the levonorgestrel releasing intrauterine system: effects on ovarian function and uterus. Arch Gynecol Obstet. 2009;280:39-42 pubmed publisher
    ..To determine the effects of levonorgestrel-releasing intrauterine system (LNG-IUS) on ovarian functions, uterine and fibroid volume...
  39. Fraser I, Romer T, Parke S, Zeun S, Mellinger U, Machlitt A, et al. Effective treatment of heavy and/or prolonged menstrual bleeding with an oral contraceptive containing estradiol valerate and dienogest: a randomized, double-blind Phase III trial. Hum Reprod. 2011;26:2698-708 pubmed publisher
    ..This double-blind trial investigated the efficacy and safety of estradiol valerate/dienogest (E(2)V/DNG) for the treatment of heavy menstrual bleeding without recognizable organic pathology...
  40. Van Voorhis B. A 41-year-old woman with menorrhagia, anemia, and fibroids: review of treatment of uterine fibroids. JAMA. 2009;301:82-93 pubmed publisher
    ..However, the case of Ms P, a 41-year-old woman with recurrent uterine fibroids, menorrhagia, anemia, and fatigue who wishes to retain fertility, illustrates the symptoms that require treatment...
  41. Endrikat J, Vilos G, Muysers C, Fortier M, Solomayer E, Lukkari Lax E. The levonorgestrel-releasing intrauterine system provides a reliable, long-term treatment option for women with idiopathic menorrhagia. Arch Gynecol Obstet. 2012;285:117-21 pubmed publisher
    Idiopathic menorrhagia (IM) is an important clinical challenge. The levonorgestrel-releasing intrauterine system (LNG IUS) provides an effective treatment option as shown by multiple small clinical studies...
  42. Murat Naki M, Tekcan C, Ozcan N, Cebi M. Levonorgestrel-releasing intrauterine device insertion ameliorates leiomyoma-dependent menorrhagia among women of reproductive age without a significant regression in the uterine and leiomyoma volumes. Fertil Steril. 2010;94:371-4 pubmed publisher
    ..LNG-IUD can be considered as a simple and effective alternative to surgical treatment in the management of leiomyoma-dependent menorrhagia of reproductive-age women.
  43. Qian Y, Gan N, Zhou J, Lu W, Ma Y, Zhang W. Microwave endometrial ablation for menorrhagia in patients with systemic disorders. Int J Gynaecol Obstet. 2005;91:32-5 pubmed
    To evaluate the effectiveness of microwave endometrial ablation (MEA) in the treatment of menorrhagia in patients with severe systemic disease or medical conditions...
  44. Pron G, Bennett J, Common A, Wall J, Asch M, Sniderman K. The Ontario Uterine Fibroid Embolization Trial. Part 2. Uterine fibroid reduction and symptom relief after uterine artery embolization for fibroids. Fertil Steril. 2003;79:120-7 pubmed
    ..Significant improvements were reported for menorrhagia (83%), dysmenorrhea (77%), and urinary frequency/urgency (86%)...
  45. Soysal M, Soysal S, Vicdan K. Thermal balloon ablation in myoma-induced menorrhagia under local anesthesia. Gynecol Obstet Invest. 2001;51:128-33 pubmed
    ..as secondary endpoints after roller ball endometrial ablation or thermal balloon ablation for myoma-induced menorrhagia. Menorrhagic women (documented by a validated pad scoring system) over 40 years of age, with a mobile myomatous ..
  46. Shaw R, Symonds I, Tamizian O, Chaplain J, Mukhopadhyay S. Randomised comparative trial of thermal balloon ablation and levonorgestrel intrauterine system in patients with idiopathic menorrhagia. Aust N Z J Obstet Gynaecol. 2007;47:335-40 pubmed
    ..thermal balloon ablation (TBA) and levonorgestrel intrauterine system (LNG-IUS) in the management of idiopathic menorrhagia and changes in pictorial blood loss assessment chart (PBAC) scores in patients who had failed on oral medical ..
  47. Tawfeek S, Sharp N. Successful microwave endometrial ablation (MEA) in uterus didelphys. J Obstet Gynaecol. 2006;26:582-3 pubmed
  48. Clegg J, Guest J, Hurskainen R. Cost-utility of levonorgestrel intrauterine system compared with hysterectomy and second generation endometrial ablative techniques in managing patients with menorrhagia in the UK. Curr Med Res Opin. 2007;23:1637-48 pubmed
    ..The model depicted the movement of patients between health states over 5 years following treatment for menorrhagia. The model was used to estimate the cost-utility of LNG-IUS followed by ablation (L-A); LNG-IUS followed by ..
  49. Warner P, Critchley H, Lumsden M, Campbell Brown M, Douglas A, Murray G. Menorrhagia I: measured blood loss, clinical features, and outcome in women with heavy periods: a survey with follow-up data. Am J Obstet Gynecol. 2004;190:1216-23 pubmed
    b>Menorrhagia is defined as blood loss of >80 mL, but in routine clinical practice measurement is seldom undertaken. Our aim was to identify the features of the clinical history that best predict menorrhagic blood loss...
  50. Fraser I, Warner P, Marantos P. Estimating menstrual blood loss in women with normal and excessive menstrual fluid volume. Obstet Gynecol. 2001;98:806-14 pubmed
    ..This simple technique has considerable clinical potential, and inexpensive commercial packs for this purpose could easily be developed. ..
  51. Santer M. Heavy menstrual bleeding: delivering patient-centred care. Br J Gen Pract. 2008;58:151-2 pubmed publisher
  52. Sambrook A, Cooper K. Second-generation treatment: microwave. Best Pract Res Clin Obstet Gynaecol. 2007;21:969-77 pubmed
    ..This article reviews the available clinical research and scientific basis of this endometrial ablation technique. ..
  53. Kujovich J. von Willebrand's disease and menorrhagia: prevalence, diagnosis, and management. Am J Hematol. 2005;79:220-8 pubmed
    The reported prevalence of von Willebrand's disease (vWD) is increased in women with menorrhagia, with current estimates ranging from 5% to 20%...
  54. Abbott J, Hawe J, Hunter D, Garry R. A double-blind randomized trial comparing the Cavaterm and the NovaSure endometrial ablation systems for the treatment of dysfunctional uterine bleeding. Fertil Steril. 2003;80:203-8 pubmed
    ..To compare two second-generation endometrial ablation systems in women with dysfunctional uterine bleeding (DUB) who want conservative surgical treatment...
  55. Kucuk T, Ertan K. Continuous oral or intramuscular medroxyprogesterone acetate versus the levonorgestrel releasing intrauterine system in the treatment of perimenopausal menorrhagia: a randomized, prospective, controlled clinical trial in female smokers. Clin Exp Obstet Gynecol. 2008;35:57-60 pubmed
    To compare the efficacy of three progestin regimens in perimenopausal menorrhagia.
  56. Pakarinen P, Luukkainen T. Treatment of menorrhagia with an LNG-IUS. Contraception. 2007;75:S118-22 pubmed
    b>Menorrhagia, also known as heavy menstrual bleeding, is defined as a menstrual blood loss is greater than 80 mL...
  57. O Flynn N, Britten N. Menorrhagia in general practice--disease or illness. Soc Sci Med. 2000;50:651-61 pubmed
    b>Menorrhagia is a common presentation in primary care. The gynaecological literature defines menorrhagia, as the loss of 80 ml or more of blood per period and guidelines for treatment are based on this definition...
  58. Soysal S, Soysal M. The efficacy of levonorgestrel-releasing intrauterine device in selected cases of myoma-related menorrhagia: a prospective controlled trial. Gynecol Obstet Invest. 2005;59:29-35 pubmed
    ..The primary outcome measures were menstrual blood flow reduction and increase in hemoglobin values. The secondary outcome measures were hysterectomy rates and patient satisfaction...
  59. Mikhail S, Varadarajan R, Kouides P. The prevalence of disorders of haemostasis in adolescents with menorrhagia referred to a haemophilia treatment centre. Haemophilia. 2007;13:627-32 pubmed
    b>Menorrhagia at the time of menarche is relatively common and historically attributed primarily to immaturity of the pituitary-ovarian-uterine axis...
  60. Protheroe J, Bower P, Chew Graham C, Peters T, Fahey T. Effectiveness of a computerized decision aid in primary care on decision making and quality of life in menorrhagia: results of the MENTIP randomized controlled trial. Med Decis Making. 2007;27:575-84 pubmed
    ..Computerized decision aids have the potential to increase patient involvement in the decision-making process. However, most published evidence concerning the effectiveness of decision aids is from secondary care...
  61. Hurskainen R, Teperi J, Aalto A, Grenman S, Kivelä A, Kujansuu E, et al. Levonorgestrel-releasing intrauterine system or hysterectomy in the treatment of essential menorrhagia: predictors of outcome. Acta Obstet Gynecol Scand. 2004;83:401-3 pubmed
    ..system (LNG-IUS) has been advocated as an effective alternative to hysterectomy in the treatment of menorrhagia. The outcome predictors have been poorly known...
  62. Farquhar C. The levonorgestrel intrauterine system: a simple and effective alternative for the management of menorrhagia?. Med J Aust. 2002;177:444-5 pubmed
  63. Trasi S, Pathare A, Shetty S, Ghosh K, Salvi V, Mohanty D. The spectrum of bleeding disorders in women with menorrhagia: a report from Western India. Ann Hematol. 2005;84:339-42 pubmed
    In order to evaluate the incidence of hereditary bleeding disorders in patients presenting with menorrhagia, where the usual gynecological and endocrinal causes of bleeding were ruled out by various local ultrasonography (USG) and ..