vitreous detachment

Summary

Summary: Detachment of the corpus vitreum (VITREOUS BODY) from its normal attachments, especially the retina, due to shrinkage from degenerative or inflammatory conditions, trauma, myopia, or senility.

Top Publications

  1. Johnson M, Van Newkirk M, Meyer K. Perifoveal vitreous detachment is the primary pathogenic event in idiopathic macular hole formation. Arch Ophthalmol. 2001;119:215-22 pubmed
    ..To evaluate the relationship between the posterior vitreous cortex and the posterior retina in eyes with early stages of idiopathic macular hole formation...
  2. Tan H, Mura M, de Smet M. Iatrogenic retinal breaks in 25-gauge macular surgery. Am J Ophthalmol. 2009;148:427-30 pubmed publisher
    ..To describe the incidence and characteristics of iatrogenic retinal breaks in 25-gauge macular surgery...
  3. Oliveira L, Tatebayashi M, Mahmoud T, Blackmon S, Wong F, McCuen B. Dispase facilitates posterior vitreous detachment during vitrectomy in young pigs. Retina. 2001;21:324-31 pubmed
    To evaluate the role of intravitreal dispase in conjunction with pars plana vitrectomy to facilitate the creation of a posterior vitreous detachment (PVD) in young pig eyes.
  4. Robison C, Krebs I, Binder S, Barbazetto I, Kotsolis A, Yannuzzi L, et al. Vitreomacular adhesion in active and end-stage age-related macular degeneration. Am J Ophthalmol. 2009;148:79-82.e2 pubmed publisher
    ..To evaluate vitreomacular relations in different stages of age-related macular degeneration (AMD) without the influence of genetics and environmental factors...
  5. Russell S, Hageman G. Optic disc, foveal, and extrafoveal damage due to surgical separation of the vitreous. Arch Ophthalmol. 2001;119:1653-8 pubmed
    ..To evaluate the morphologic outcomes resulting from surgical vitreoretinal separation in young adult primates...
  6. Besirli C, Johnson M. Traction-induced foveal damage predisposes eyes with pre-existing posterior vitreous detachment to idiopathic macular hole formation. Eye (Lond). 2012;26:792-5 pubmed publisher
    To propose a new mechanism for the development of idiopathic macular hole in the setting of pre-existing posterior vitreous detachment (PVD).
  7. Murakami T, Takagi H, Ohashi H, Kita M, Nishiwaki H, Miyamoto K, et al. Role of posterior vitreous detachment induced by intravitreal tissue plasminogen activator in macular edema with central retinal vein occlusion. Retina. 2007;27:1031-7 pubmed
    To evaluate the effects of posterior vitreous detachment (PVD) in macular edema associated with central retinal vein occlusion (CRVO) treated with intravitreal tissue plasminogen activator (tPA).
  8. Kičová N, Bertelmann T, Irle S, Sekundo W, Mennel S. Evaluation of a posterior vitreous detachment: a comparison of biomicroscopy, B-scan ultrasonography and optical coherence tomography to surgical findings with chromodissection. Acta Ophthalmol. 2012;90:e264-8 pubmed publisher
    To find the most reliable and efficient noninvasive technique to clinically detect a posterior vitreous detachment.
  9. Le Goff M, Bishop P. Adult vitreous structure and postnatal changes. Eye (Lond). 2008;22:1214-22 pubmed publisher
    ..ageing changes throughout life that result in vitreous liquefaction and a predisposition towards posterior vitreous detachment and retinal break formation...

More Information

Publications62

  1. Yamamoto S, Yamamoto T, Ogata K, Hoshino A, Sato E, Mizunoya S. Morphological and functional changes of the macula after vitrectomy and creation of posterior vitreous detachment in eyes with diabetic macular edema. Doc Ophthalmol. 2004;109:249-53 pubmed
    ..and functional changes in the macula after pars plana vitrectomy with the creation of a posterior vitreous detachment in eyes with diabetic macular edema (DME)...
  2. Johnson M. Perifoveal vitreous detachment and its macular complications. Trans Am Ophthalmol Soc. 2005;103:537-67 pubmed
    To evaluate the vitreoretinal relationship in eyes with idiopathic macular disorders putatively caused by vitreomacular traction associated with early stages of age-related posterior vitreous detachment (PVD).
  3. Funatsu H, Yamashita H, Ikeda T, Mimura T, Shimizu E, Hori S. Relation of diabetic macular edema to cytokines and posterior vitreous detachment. Am J Ophthalmol. 2003;135:321-7 pubmed
    To investigate whether angiotensin II (AII) or vascular endothelial growth factor (VEGF) is related to diabetic macular edema (DME) in patients with and without posterior vitreous detachment (PVD).
  4. Shao L, Xu L, You Q, Wang Y, Chen C, Yang H, et al. Prevalence and associations of incomplete posterior vitreous detachment in adult Chinese: the Beijing Eye Study. PLoS ONE. 2013;8:e58498 pubmed publisher
    To determine prevalence and associations of incomplete posterior vitreous detachment (PVD).
  5. Krebs I, Brannath W, Glittenberg C, Zeiler F, Sebag J, Binder S. Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration?. Am J Ophthalmol. 2007;144:741-746 pubmed
    ..To compare the state of the posterior vitreous in exudative age-related macular degeneration (AMD) with eyes with nonexudative AMD and controls...
  6. Mori K, Saito S, Gehlbach P, Yoneya S. Treatment of stage 2 macular hole by intravitreous injection of expansile gas and induction of posterior vitreous detachment. Ophthalmology. 2007;114:127-33 pubmed
    ..To demonstrate the morphological and functional outcomes of intravitreous injection of an expansile gas bubble for the treatment of stage 2 macular holes...
  7. Chuo J, Lee T, Hollands H, Morris A, Reyes R, Rossiter J, et al. Risk factors for posterior vitreous detachment: a case-control study. Am J Ophthalmol. 2006;142:931-7 pubmed
    To identify possible risk factors for the development of posterior vitreous detachment (PVD).
  8. Modarres M, Sanjari M, Falavarjani K. Vitrectomy and release of presumed epipapillary vitreous traction for treatment of nonarteritic anterior ischemic optic neuropathy associated with partial posterior vitreous detachment. Ophthalmology. 2007;114:340-4 pubmed
    To study the results of vitrectomy and release of epipapillary vitreous adhesions for the treatment of nonarteritic anterior ischemic optic neuropathy (NAION) associated with partial posterior vitreous detachment (PVD).
  9. Ophir A, Martinez M. Epiretinal membranes and incomplete posterior vitreous detachment in diabetic macular edema, detected by spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2011;52:6414-20 pubmed publisher
    ..in diabetic macular edema (DME) associated with both epiretinal membrane (ERM) and incomplete posterior vitreous detachment (PVD), as detected by spectral-domain optical coherence tomography (SD-OCT). METHODS...
  10. Giblin F, Quiram P, Leverenz V, Baker R, Dang L, Trese M. Enzyme-induced posterior vitreous detachment in the rat produces increased lens nuclear pO2 levels. Exp Eye Res. 2009;88:286-92 pubmed publisher
    ..and rats (which possess a vascular retina) to produce either vitreous humor liquefaction plus a posterior vitreous detachment (PVD) (with use of microplasmin) or vitreous humor liquefaction only (with use of hyaluronidase), and 1-2 ..
  11. Li X, Shi X, Fan J. Posterior vitreous detachment with plasmin in the isolated human eye. Graefes Arch Clin Exp Ophthalmol. 2002;240:56-62 pubmed
    To investigate the efficacy and safety of intravitreal injection of plasmin in producing posterior vitreous detachment (PVD), and the possible role of plasmin in degrading adhesion glycoproteins of the internal limiting membrane (ILM).
  12. de Smet M, Gandorfer A, Stalmans P, Veckeneer M, Feron E, Pakola S, et al. Microplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy: the MIVI I trial. Ophthalmology. 2009;116:1349-55, 1355.e1-2 pubmed publisher
    ..To evaluate the safety and preliminary efficacy of 4 doses and several exposure times of intravitreal microplasmin given before pars plana vitrectomy for vitreomacular traction maculopathy...
  13. Mojana F, Cheng L, Bartsch D, Silva G, Kozak I, Nigam N, et al. The role of abnormal vitreomacular adhesion in age-related macular degeneration: spectral optical coherence tomography and surgical results. Am J Ophthalmol. 2008;146:218-227 pubmed publisher
  14. Smith R, Yadarola M, Pelizzari M, Luna J, Juarez C, Reviglio V. Complete bilateral vitreous detachment after LASIK retreatment. J Cataract Refract Surg. 2004;30:1382-4 pubmed
    ..Funduscopic examination revealed a complete bilateral posterior vitreous detachment confirmed by kinetic ultrasound...
  15. Gavrilov J, Gaujoux T, Sellam M, Laroche L, Borderie V. Occurrence of posterior vitreous detachment after femtosecond laser in situ keratomileusis: Ultrasound evaluation. J Cataract Refract Surg. 2011;37:1300-4 pubmed publisher
    ..To analyze the modifications to the vitreous body after femtosecond laser-assisted laser in situ keratomileusis (LASIK) for myopia...
  16. Takano A, Hirata A, Ogasawara K, Sagara N, Inomata Y, Kawaji T, et al. Posterior vitreous detachment induced by nattokinase (subtilisin NAT): a novel enzyme for pharmacologic vitreolysis. Invest Ophthalmol Vis Sci. 2006;47:2075-9 pubmed
    To investigate the effects of intravitreal injection of nattokinase (subtilisin NAT), a serine protease that is produced by Bacillus subtilis (natto), for induction of posterior vitreous detachment (PVD).
  17. Zhi Liang W, Wo Dong S, Min L, Xiao Ping B, Jin J. Pharmacologic vitreolysis with plasmin and hyaluronidase in diabetic rats. Retina. 2009;29:269-74 pubmed publisher
    To evaluate the feasibility of inducing posterior vitreous detachment (PVD) with pharmacologic vitreolysis in diabetic rats.
  18. Chung S, Kim K, Kang S. Retinal breaks associated with the induction of posterior vitreous detachment. Am J Ophthalmol. 2009;147:1012-6 pubmed publisher
    To evaluate the correlation between the incidence of vitrectomy-related retinal breaks and the induction of a posterior vitreous detachment (PVD).
  19. Gella L, Raman R, Kulothungan V, Sharma T. Prevalence of posterior vitreous detachment in the population with type II diabetes mellitus and its effect on diabetic retinopathy: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study SN-DREAMS report no. 23. Jpn J Ophthalmol. 2012;56:262-7 pubmed publisher
    To report the prevalence of posterior vitreous detachment (PVD), and predisposing factors to PVD and their effect on diabetic retinopathy.
  20. Takahashi A, Yoshida A, Nagaoka T, Takamiya A, Sato E, Kagokawa H, et al. Idiopathic full-thickness macular holes and the vitreomacular interface: a high-resolution spectral-domain optical coherence tomography study. Am J Ophthalmol. 2012;154:881-892.e2 pubmed publisher
    ..To analyze the vitreomacular interface in idiopathic full-thickness macular holes (MHs) using spectral-domain optical coherence tomography...
  21. de Smet M, Valmaggia C, Zarranz Ventura J, Willekens B. Microplasmin: ex vivo characterization of its activity in porcine vitreous. Invest Ophthalmol Vis Sci. 2009;50:814-9 pubmed publisher
    ..Its enzymatic activity is similar to that of plasmin enzyme. The present study characterizes in a porcine eye model the vitreolytic ability of microplasmin...
  22. Mirshahi A, Hohn F, Lorenz K, Hattenbach L. Incidence of posterior vitreous detachment after cataract surgery. J Cataract Refract Surg. 2009;35:987-91 pubmed publisher
    To report the incidence of posterior vitreous detachment (PVD) after uneventful state-of-the-art small-incision phacoemulsification with implantation of a posterior chamber intraocular lens (PC IOL).
  23. Koizumi H, Spaide R, Fisher Y, Freund K, Klancnik J, Yannuzzi L. Three-dimensional evaluation of vitreomacular traction and epiretinal membrane using spectral-domain optical coherence tomography. Am J Ophthalmol. 2008;145:509-517 pubmed publisher
    ..To delineate the 3-dimensional (3-D) relationship in vitreomacular traction (VMT) and idiopathic epiretinal membrane (ERM)...
  24. Chen W, Mo W, Sun K, Huang X, Zhang Y, Song H. Microplasmin degrades fibronectin and laminin at vitreoretinal interface and outer retina during enzymatic vitrectomy. Curr Eye Res. 2009;34:1057-64 pubmed publisher
    To determine whether intravitreal administration of microplasmin (microPlm) will degrade fibronectin (FN) and laminin (LN) in rat retina during microPlm-induced posterior vitreous detachment (PVD).
  25. Stalmans P, Delaey C, de Smet M, van Dijkman E, Pakola S. Intravitreal injection of microplasmin for treatment of vitreomacular adhesion: results of a prospective, randomized, sham-controlled phase II trial (the MIVI-IIT trial). Retina. 2010;30:1122-7 pubmed publisher
    ..It may be avoided by using enzymatic vitreolysis. The MIVI-IIT (traction) study evaluated the ability of a single or repeated injection of microplasmin to release vitreomacular traction...
  26. Lorusso M, Micelli Ferrari L, Leozappa M, Modoni A, Micelli Ferrari T. Transient vitreomacular traction syndrome caused by traumatic incomplete posterior vitreous detachment. Eur J Ophthalmol. 2011;21:668-70 pubmed publisher
    To report transient vitreomacular traction (VMT) syndrome following acute blunt trauma associated with incomplete posterior vitreous detachment.
  27. Johnson M. Tractional cystoid macular edema: a subtle variant of the vitreomacular traction syndrome. Am J Ophthalmol. 2005;140:184-92 pubmed
    ..To describe clinical characteristics and treatment outcomes in a series of patients with tractional cystoid macular edema, a subtle variant of the vitreomacular traction syndrome...
  28. Yamada N, Kishi S. Tomographic features and surgical outcomes of vitreomacular traction syndrome. Am J Ophthalmol. 2005;139:112-7 pubmed
    ..To study the relation between preoperative macular changes and surgical outcomes in vitreomacular traction syndrome...
  29. Hayreh S, Jonas J. Posterior vitreous detachment: clinical correlations. Ophthalmologica. 2004;218:333-43 pubmed
    To evaluate the frequency of, and the factors which are primarily and secondarily associated with, posterior vitreous detachment (PVD), and to correlate the presence of PVD with various demographic and ophthalmic entities.
  30. Sebag J. Anomalous posterior vitreous detachment: a unifying concept in vitreo-retinal disease. Graefes Arch Clin Exp Ophthalmol. 2004;242:690-8 pubmed
    Posterior vitreous detachment (PVD) is the consequence of changes in the macromolecular structure of gel vitreous that result in liquefaction, concurrent with alterations in the extracellular matrix at the vitro-retinal interface that ..
  31. Charbonnel J, Glacet Bernard A, Korobelnik J, Nyouma Moune E, Pournaras C, Colin J, et al. Management of branch retinal vein occlusion with vitrectomy and arteriovenous adventitial sheathotomy, the possible role of surgical posterior vitreous detachment. Graefes Arch Clin Exp Ophthalmol. 2004;242:223-8 pubmed
    ..To analyze the results of vitrectomy and adventitial sheathotomy in the management of branch retinal vein occlusion (BRVO). This is a nonrandomized interventional case series...
  32. Ito Y, Terasaki H, Suzuki T, Kojima T, Mori M, Ishikawa K, et al. Mapping posterior vitreous detachment by optical coherence tomography in eyes with idiopathic macular hole. Am J Ophthalmol. 2003;135:351-5 pubmed
    To determine the relationship between posterior vitreous detachment and idiopathic macular hole.
  33. Uchino E, Uemura A, Doi N, Ohba N. Postsurgical evaluation of idiopathic vitreomacular traction syndrome by optical coherence tomography. Am J Ophthalmol. 2001;132:122-3 pubmed
    ..To report a case of idiopathic vitreomacular traction syndrome with preoperative and postoperative evaluation by optical coherence tomography...
  34. Alkabes M, Salinas C, Vitale L, Burés Jelstrup A, Nucci P, Mateo C. En face optical coherence tomography of inner retinal defects after internal limiting membrane peeling for idiopathic macular hole. Invest Ophthalmol Vis Sci. 2011;52:8349-55 pubmed publisher
    ..To describe the appearance of inner retinal defects using en face spectral domain optical coherence tomography (SD-OCT) after idiopathic full-thickness macular hole (FTMH) surgery, referred to as concentric macular dark spots (CMDS)...
  35. Geck U, Pustolla N, Baraki H, Atili A, Feltgen N, Hoerauf H. Posterior vitreous detachment following intravitreal drug injection. Graefes Arch Clin Exp Ophthalmol. 2013;251:1691-5 pubmed publisher
    To evaluate the incidence of posterior vitreous detachment (PVD) induced by intravitreal injection of different intravitreal drugs.
  36. Tanner V, Harle D, Tan J, Foote B, Williamson T, Chignell A. Acute posterior vitreous detachment: the predictive value of vitreous pigment and symptomatology. Br J Ophthalmol. 2000;84:1264-8 pubmed
    ..the presence of a retinal break can be predicted either by the presence of a positive Shafer's sign (pigment granules in the anterior vitreous) or symptomatology in patients presenting with an acute posterior vitreous detachment (PVD).
  37. Shen Z, Duan X, Wang F, Wang N, Peng Y, Liu D, et al. Prevalence and risk factors of posterior vitreous detachment in a Chinese adult population: the Handan eye study. BMC Ophthalmol. 2013;13:33 pubmed publisher
    To describe the prevalence and associations of posterior vitreous detachment (PVD) in a rural adult Chinese population.
  38. Hohn F, Mirshahi A, Hattenbach L. Optical coherence tomography for diagnosis of posterior vitreous detachment at the macular region. Eur J Ophthalmol. 2009;19:442-7 pubmed
    To assess optical coherence tomography (OCT) for diagnosing posterior vitreous detachment (PVD) at the macular region compared to kinetic B-scan ultrasonography.
  39. Ripandelli G, Coppè A, Parisi V, Olzi D, Scassa C, Chiaravalloti A, et al. Posterior vitreous detachment and retinal detachment after cataract surgery. Ophthalmology. 2007;114:692-7 pubmed
    ..To evaluate possible changes of vitreous status in emmetropic eyes after uneventful phacoemulsification surgery, and possible related complications such as the onset of retinal detachment (RD)...
  40. Sakuma T, Tanaka M, Mizota A, Inoue J, Pakola S. Safety of in vivo pharmacologic vitreolysis with recombinant microplasmin in rabbit eyes. Invest Ophthalmol Vis Sci. 2005;46:3295-9 pubmed
    To investigate the safety of intravitreal microplasmin in rabbits and to confirm previous findings of posterior vitreous detachment (PVD).
  41. Larsson J. Vitrectomy in vitreomacular traction syndrome evaluated by ocular coherence tomography (OCT) retinal mapping. Acta Ophthalmol Scand. 2004;82:691-4 pubmed
    ..To evaluate vitreomacular traction syndrome with ocular coherence tomography (OCT) retinal mapping before and after vitrectomy...
  42. Men G, Peyman G, Genaidy M, Kuo P, Ghahramani F, Blake D, et al. The role of recombinant lysine-plasminogen and recombinant urokinase and sulfur hexafluoride combination in inducing posterior vitreous detachment. Retina. 2004;24:199-209 pubmed
    ..determine the optimal method of generating plasmin in vitreous using recombinant lysine-plasminogen and recombinant urokinase and to determine its efficacy in inducing posterior vitreous detachment when combined with sulfur hexafluoride.
  43. Freund K, Ciardella A, Shah V, Yannuzzi L, Fisher Y. Optical coherence tomography documentation of spontaneous macular hole closure without posterior vitreous detachment. Retina. 2002;22:506-9 pubmed
  44. Yamamoto T, Akabane N, Takeuchi S. Vitrectomy for diabetic macular edema: the role of posterior vitreous detachment and epimacular membrane. Am J Ophthalmol. 2001;132:369-77 pubmed
    To evaluate the surgical efficacy of pars plana vitrectomy on eyes with diabetic macular edema in the presence or absence of a complete posterior vitreous detachment and with or without an epimacular membrane.
  45. Ochoa Contreras D, Delsol Coronado L, Buitrago M, Velasco Barona C, Quiroz Mercado H. Induced posterior vitreous detachment by intravitreal sulfur hexafluoride (SF6) injection in patients with nonproliferative diabetic retinopathy. Acta Ophthalmol Scand. 2000;78:687-8 pubmed
    To induce posterior vitreous detachment (PVD) in patients with nonproliferative diabetic retinopathy (NPDR) by injecting an intravitreal gas bubble of SF6 and to compare the evolution of the diabetic retinopathy between eyes with gas ..
  46. Quiram P, Leverenz V, Baker R, Dang L, Giblin F, Trese M. Microplasmin-induced posterior vitreous detachment affects vitreous oxygen levels. Retina. 2007;27:1090-6 pubmed
    To determine if enzymatic induction of a posterior vitreous detachment (PVD) and/or vitreous liquefaction affects O2 concentration in the vitreous cavity in animals with vascularized and avascular retinal circulations.
  47. Johnson M. Posterior vitreous detachment: evolution and complications of its early stages. Am J Ophthalmol. 2010;149:371-82.e1 pubmed publisher
    To summarize emerging concepts regarding the onset and progression, traction effects, and complications of the early stages of age-related posterior vitreous detachment (PVD).
  48. Goldenberg D, Giblin F, Cheng M, Chintala S, Trese M, Drenser K, et al. Posterior vitreous detachment with microplasmin alters the retinal penetration of intravitreal bevacizumab (Avastin) in rabbit eyes. Retina. 2011;31:393-400 pubmed publisher
    ..Intravitreal recombinant microplasmin (MP) has been shown to successfully induce a posterior vitreous detachment (PVD) and vitreous liquefaction in animals...
  49. Mirshahi A, Schöpfer D, Gerhardt D, Terzi E, Kasper T, Kohnen T. Incidence of posterior vitreous detachment after laser in situ keratomileusis. Graefes Arch Clin Exp Ophthalmol. 2006;244:149-53 pubmed
    ..The purpose of this study was to determine the effect of LASIK on the vitreous body...
  50. Gaucher D, Tadayoni R, Erginay A, Haouchine B, Gaudric A, Massin P. Optical coherence tomography assessment of the vitreoretinal relationship in diabetic macular edema. Am J Ophthalmol. 2005;139:807-13 pubmed
    ..To study the vitreoretinal relationship in diabetic patients with and without diabetic macular edema (DME) using optical coherence tomography...
  51. Azzolini C, D Angelo A, Maestranzi G, Codenotti M, Della Valle P, Prati M, et al. Intrasurgical plasmin enzyme in diabetic macular edema. Am J Ophthalmol. 2004;138:560-6 pubmed
    To evaluate in a prospective study the efficacy of intrasurgical autologous plasmin enzyme (APE) in producing posterior vitreous detachment.
  52. Spaide R, Wong D, Fisher Y, Goldbaum M. Correlation of vitreous attachment and foveal deformation in early macular hole states. Am J Ophthalmol. 2002;133:226-9 pubmed
    ..To report the foveal anatomy in patients with perifoveal posterior vitreous detachments (PPVD) using optical coherence tomography...
  53. Uchino E, Uemura A, Ohba N. Initial stages of posterior vitreous detachment in healthy eyes of older persons evaluated by optical coherence tomography. Arch Ophthalmol. 2001;119:1475-9 pubmed
    To promote understanding of the development of posterior vitreous detachment (PVD) in healthy eyes using optical coherence tomography (OCT).