choroid diseases

Summary

Summary: Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.

Top Publications

  1. Mancino R, Varesi C, Cerulli A, Aiello F, Nucci C. Acute bilateral angle-closure glaucoma and choroidal effusion associated with acetazolamide administration after cataract surgery. J Cataract Refract Surg. 2011;37:415-7 pubmed publisher
    ..Although extremely rare, this adverse effect should be considered in patients who develop acute bilateral angle-closure glaucoma and choroidal effusion after cataract surgery...
  2. Yoshida Y, Kohno T, Yamamoto M, Yoneda T, Iwami H, Shiraki K. Two-year results of reduced-fluence photodynamic therapy combined with intravitreal ranibizumab for typical age-related macular degeneration and polypoidal choroidal vasculopathy. Jpn J Ophthalmol. 2013;57:283-93 pubmed publisher
    ..To report the 2-year results of reduced-fluence photodynamic therapy (RF-PDT) combined with intravitreal ranibizumab (IVR) for typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV)...
  3. Reche Frutos J, Calvo Gonzalez C, Donate Lopez J, Garcia Feijoo J, Leila M, Garcia Sanchez J. Short-term anatomic effect of ranibizumab for polypoidal choroidal vasculopathy. Eur J Ophthalmol. 2008;18:645-8 pubmed
    ..To assess the short-term anatomic effect of intravitreal ranibizumab for polypoidal choroidal vasculopathy...
  4. Gotoh N, Yamashiro K, Nakanishi H, Saito M, Iida T, Yoshimura N. Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy. Jpn J Ophthalmol. 2010;54:609-14 pubmed publisher
    ..2 kb, were genotyped. Associations were tested using single-SNP and haplotype analyses...
  5. Ohno Matsui K, Shimada N, Akiba M, Moriyama M, Ishibashi T, Tokoro T. Characteristics of intrachoroidal cavitation located temporal to optic disc in highly myopic eyes. Eye (Lond). 2013;27:630-8 pubmed publisher
    ..To investigate the anatomic characteristics of eyes with pathological myopia and peripapillary intrachoroidal cavitation (ICC) located temporal to the optic disc...
  6. de Crecchio G, Chan R, Manzi G, Romano M. Polypoidal choroidal vasculopathy: recent advances in therapy. Curr Drug Targets. 2011;12:206-11 pubmed
    ..PCV and its treatment are discussed, including the use of combination therapy...
  7. Maruko I, Iida T, Sugano Y, Saito M, Sekiryu T. Subfoveal retinal and choroidal thickness after verteporfin photodynamic therapy for polypoidal choroidal vasculopathy. Am J Ophthalmol. 2011;151:594-603.e1 pubmed publisher
    ..To evaluate the morphologic retinal and choroidal changes after verteporfin photodynamic therapy (PDT) with and without ranibizumab for polypoidal choroidal vasculopathy using spectral-domain optical coherence tomography...
  8. Spaide R, Akiba M, Ohno Matsui K. Evaluation of peripapillary intrachoroidal cavitation with swept source and enhanced depth imaging optical coherence tomography. Retina. 2012;32:1037-44 pubmed publisher
  9. Honda S, Kurimoto Y, Kagotani Y, Yamamoto H, Takagi H, Uenishi M. Photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy: a 30-month multicenter study in Hyogo, Japan. Jpn J Ophthalmol. 2009;53:593-597 pubmed publisher
    ..PDT may have some advantages for PCV patients, but not for tAMD patients. However, as PCV often recurred 12 months post-PDT, long-term observation after the treatment is crucial. ..

More Information

Publications62

  1. Kokame G, Yeung L, Lai J. Continuous anti-VEGF treatment with ranibizumab for polypoidal choroidal vasculopathy: 6-month results. Br J Ophthalmol. 2010;94:297-301 pubmed publisher
    ..To evaluate the short-term efficacy and safety of monthly intravitreal injections of ranibizumab in patients with polypoidal choroidal vasculopathy (PCV) and active exudation or haemorrhage...
  2. Bessho H, Honda S, Imai H, Negi A. Natural course and funduscopic findings of polypoidal choroidal vasculopathy in a Japanese population over 1 year of follow-up. Retina. 2011;31:1598-602 pubmed publisher
    ..To evaluate the natural course and possible funduscopic risk factors for polypoidal choroidal vasculopathy in a Japanese population...
  3. Bessho H, Kondo N, Honda S, Kuno S, Negi A. Coding variant Met72Thr in the PEDF gene and risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. Mol Vis. 2009;15:1107-14 pubmed
    ..The aim of this study was to validate the previously reported association of the PEDF Met72Thr variant in a well characterized Japanese population with neovascular AMD and PCV...
  4. Lee W, Lee P, Lee S. Photodynamic therapy for polypoidal choroidal vasculopathy: vaso-occlusive effect on the branching vascular network and origin of recurrence. Jpn J Ophthalmol. 2008;52:108-115 pubmed publisher
    ..To determine whether photodynamic therapy (PDT) has a vaso-occlusive effect on the branching vascular network in polypoidal choroidal vasculopathy (PCV) and whether PDT can prevent future recurrence...
  5. Imamura Y, Engelbert M, Iida T, Freund K, Yannuzzi L. Polypoidal choroidal vasculopathy: a review. Surv Ophthalmol. 2010;55:501-15 pubmed publisher
    ..We emphasize multimodal ophthalmic imaging of these vessels, in particular fluorescein and indocyanine green angiography and optical coherence tomography...
  6. Hayashi H, Yamashiro K, Gotoh N, Nakanishi H, Nakata I, Tsujikawa A, et al. CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation. Invest Ophthalmol Vis Sci. 2010;51:5914-9 pubmed publisher
  7. Lima L, Schubert C, Ferrara D, Merriam J, Imamura Y, Freund K, et al. Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy. Ophthalmology. 2010;117:1567-70 pubmed publisher
    ..To investigate the frequency of variants in 3 major age-related macular degeneration (AMD)-associated loci in patients of European-American descent with polypoidal choroidal vasculopathy (PCV)...
  8. Hikichi T, Higuchi M, Matsushita T, Kosaka S, Matsushita R, Takami K, et al. One-year results of three monthly ranibizumab injections and as-needed reinjections for polypoidal choroidal vasculopathy in Japanese patients. Am J Ophthalmol. 2012;154:117-124.e1 pubmed publisher
    ..To investigate the 1-year outcomes of monthly intravitreal injections of ranibizumab for 3 months followed by an as-needed reinjection schedule to treat polypoidal choroidal vasculopathy (PCV) in Japanese patients...
  9. Lehmann M, Wolff B, Vasseur V, Martinet V, Manasseh N, Sahel J, et al. Retinal and choroidal changes observed with 'En face' enhanced-depth imaging OCT in central serous chorioretinopathy. Br J Ophthalmol. 2013;97:1181-6 pubmed publisher
    ..To describe retinal and choroidal changes in acute and quiescent central serous chorioretinopathy (CSC) observed with 'En face' spectral domain optical coherence tomography (SD OCT) combined with enhanced-depth imaging (EDI)...
  10. Koh A, Chen L, Chen S, Chen Y, Giridhar A, Iida T, et al. Polypoidal choroidal vasculopathy: evidence-based guidelines for clinical diagnosis and treatment. Retina. 2013;33:686-716 pubmed publisher
    ..Currently, no evidence-based guidelines exist for its diagnosis and treatment...
  11. Yamashiro K, Tomita K, Tsujikawa A, Nakata I, Akagi Kurashige Y, Miyake M, et al. Factors associated with the response of age-related macular degeneration to intravitreal ranibizumab treatment. Am J Ophthalmol. 2012;154:125-36 pubmed publisher
    ..To investigate factors affecting patient response to intravitreal ranibizumab treatment for age-related macular degeneration (AMD)...
  12. Zeng R, Wen F, Zhang X, Zuo C, Li M, Chen H, et al. An rs9621532 variant near the TIMP3 gene is not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Chinese Han population. Ophthalmic Genet. 2012;33:139-43 pubmed publisher
    ..In this study, we aimed to investigate whether the rs9621532 SNP is associated with neovascular AMD (nAMD) and PCV in a Chinese Han population...
  13. Wu K, Wen F, Zuo C, Li M, Zhang X, Chen H, et al. Lack of association with PEDF Met72Thr variant in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Han Chinese population. Curr Eye Res. 2012;37:68-72 pubmed publisher
  14. Lai T, Lee G, Luk F, Lam D. Intravitreal ranibizumab with or without photodynamic therapy for the treatment of symptomatic polypoidal choroidal vasculopathy. Retina. 2011;31:1581-8 pubmed publisher
    ..To evaluate the efficacy of intravitreal ranibizumab with or without verteporfin photodynamic therapy (PDT) in the treatment of symptomatic polypoidal choroidal vasculopathy...
  15. Kondo N, Honda S, Kuno S, Negi A. Coding variant I62V in the complement factor H gene is strongly associated with polypoidal choroidal vasculopathy. Ophthalmology. 2009;116:304-10 pubmed publisher
    ..To investigate whether variants in the complement factor H (CFH) gene are associated with polypoidal choroidal vasculopathy (PCV)...
  16. Koh A, Lee W, Chen L, Chen S, Hashad Y, Kim H, et al. EVEREST study: efficacy and safety of verteporfin photodynamic therapy in combination with ranibizumab or alone versus ranibizumab monotherapy in patients with symptomatic macular polypoidal choroidal vasculopathy. Retina. 2012;32:1453-64 pubmed
    ..To assess the effects of verteporfin photodynamic therapy (PDT) combined with ranibizumab or alone versus ranibizumab monotherapy in patients with symptomatic macular polypoidal choroidal vasculopathy...
  17. Mantel I, Uffer S, Zografos L. Peripheral exudative hemorrhagic chorioretinopathy: a clinical, angiographic, and histologic study. Am J Ophthalmol. 2009;148:932-8.e1 pubmed publisher
  18. Zhang X, Wen F, Zuo C, Li M, Chen H, Wu K. Association of genetic variation on chromosome 9p21 with polypoidal choroidal vasculopathy and neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52:8063-7 pubmed publisher
    ..In this study, the association of identified risk variants for intracranial aneurysm on chromosome 9p21 with PCV and neovascular AMD in a Chinese Han population was investigated...
  19. Li M, Wen F, Zuo C, Zhang X, Chen H, Huang S, et al. SERPING1 polymorphisms in polypoidal choroidal vasculopathy. Mol Vis. 2010;16:231-9 pubmed
    ..To investigate whether common genetic variants in the complement component 1 inhibitor gene (serpin peptidase inhibitor, clade G, member 1, SERPING1) are associated with polypoidal choroidal vasculopathy (PCV) in a Chinese Han population...
  20. Song M, Ryu H, Roh Y. One-year results of intravitreal ranibizumab with or without photodynamic therapy for polypoidal choroidal vasculopathy. Ophthalmologica. 2011;226:119-26 pubmed publisher
    ..To evaluate the safety and efficacy of intravitreal ranibizumab with or without photodynamic therapy (PDT) in the treatment of polypoidal choroidal vasculopathy (PCV) in Korean patients...
  21. Koizumi H, Yamagishi T, Yamazaki T, Kinoshita S. Relationship between clinical characteristics of polypoidal choroidal vasculopathy and choroidal vascular hyperpermeability. Am J Ophthalmol. 2013;155:305-313.e1 pubmed publisher
    ..To investigate the relationship between the clinical characteristics of polypoidal choroidal vasculopathy (PCV) and choroidal vascular hyperpermeability seen on indocyanine green angiography...
  22. Stangos A, Gandhi J, Nair Sahni J, Heimann H, Pournaras C, Harding S. Polypoidal choroidal vasculopathy masquerading as neovascular age-related macular degeneration refractory to ranibizumab. Am J Ophthalmol. 2010;150:666-73 pubmed publisher
    ..To report a neovascular age-related macular degeneration pattern refractory to ranibizumab...
  23. Yeh S, Chang W, Wu C, Lan Y, Hsieh J, Tsai S, et al. Characteristics of peripapillary choroidal cavitation detected by optical coherence tomography. Ophthalmology. 2013;120:544-552 pubmed publisher
    ..Although its pathogenesis and pathologic significance require further investigation, PCC may be a degenerative change in aging eyes. ..
  24. Yamagishi T, Koizumi H, Yamazaki T, Kinoshita S. Fundus autofluorescence in polypoidal choroidal vasculopathy. Ophthalmology. 2012;119:1650-7 pubmed publisher
    ..To investigate and compare the characteristics of fundus autofluorescence (FAF) in polypoidal choroidal vasculopathy (PCV) with those in typical neovascular age-related macular degeneration (AMD)...
  25. Mrejen S, Spaide R. Optical coherence tomography: imaging of the choroid and beyond. Surv Ophthalmol. 2013;58:387-429 pubmed publisher
    ..Future developments will include blood flow information, 3D rendering of various ocular structures, and the ability to evaluate changes in 3D structural information over time (4D imaging)...
  26. Park S, Kim S, Song Y, Sung J, Ham D. Retinal thickness and volume measured with enhanced depth imaging optical coherence tomography. Am J Ophthalmol. 2013;156:557-566.e2 pubmed publisher
  27. Park D, Kim I. Association of ARMS2/HTRA1 variants with polypoidal choroidal vasculopathy phenotype in a Korean population. Jpn J Ophthalmol. 2012;56:60-7 pubmed publisher
    ..To investigate whether ARMS2 (rs10490924)/HTRA1 (rs11200638) variants are associated with polypoidal choroidal vasculopathy (PCV) in a Korean population and with various PCV phenotypes...
  28. Rouvas A, Papakostas T, Ntouraki A, Douvali M, Vergados I, Ladas I. Photodynamic therapy, ranibizumab, and ranibizumab with photodynamic therapy for the treatment of polypoidal choroidal vasculopathy. Retina. 2011;31:464-74 pubmed publisher
    ..The purpose of this study was to compare photodynamic therapy (PDT), ranibizumab, and ranibizumab with PDT in polypoidal choroidal vasculopathy...
  29. Hikichi T, Ohtsuka H, Higuchi M, Matsushita T, Ariga H, Kosaka S, et al. Improvement of angiographic findings of polypoidal choroidal vasculopathy after intravitreal injection of ranibizumab monthly for 3 months. Am J Ophthalmol. 2010;150:674-682.e1 pubmed publisher
  30. Cackett P, Wong D, Yeo I. A classification system for polypoidal choroidal vasculopathy. Retina. 2009;29:187-91 pubmed publisher
    ..To describe the demographic features and clinical characteristics of polypoidal choroidal vasculopathy (PCV) in Chinese patients and define a new classification system...
  31. Wakabayashi T, Gomi F, Sawa M, Tsujikawa M, Tano Y. Marked vascular changes of polypoidal choroidal vasculopathy after photodynamic therapy. Br J Ophthalmol. 2008;92:936-40 pubmed publisher
    ..To clarify vascular changes of polypoidal choroidal vasculopathy (PCV) after photodynamic therapy (PDT)...
  32. Hikichi T, Ohtsuka H, Higuchi M, Matsushita T, Ariga H, Kosaka S, et al. Factors predictive of visual acuity outcomes 1 year after photodynamic therapy in Japanese patients with polypoidal choroidal vasculopathy. Retina. 2011;31:857-65 pubmed publisher
    ..The purpose of this study was to determine the factors predictive of visual acuity (VA) outcomes 1 year after photodynamic therapy (PDT) for polypoidal choroidal vasculopathy...
  33. Akaza E, Yuzawa M, Mori R. Three-year follow-up results of photodynamic therapy for polypoidal choroidal vasculopathy. Jpn J Ophthalmol. 2011;55:39-44 pubmed publisher
    ..To evaluate the visual outcomes and changes in abnormal vascular networks and polypoidal lesions of polypoidal choroidal vasculopathy (PCV) 3 years after photodynamic therapy (PDT)...
  34. Kondo N, Honda S, Kuno S, Negi A. Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology. Ophthalmology. 2009;116:1502-9 pubmed publisher
  35. Fujiwara T, Imamura Y, Margolis R, Slakter J, Spaide R. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol. 2009;148:445-50 pubmed publisher
    ..To measure macular choroidal thickness (CT) in highly myopic eyes using enhanced depth imaging optical coherence tomography (OCT)...
  36. Lee K, Vithana E, Mathur R, Yong V, Yeo I, Thalamuthu A, et al. Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci. 2008;49:2613-9 pubmed publisher
    ..Variants in the C2 and BF genes have been found to confer a significantly reduced risk of AMD. This study was undertaken to determine whether these associations occur in Chinese patients with PCV...
  37. Sato T, Kishi S, Matsumoto H, Mukai R. Comparisons of outcomes with different intervals between adjunctive ranibizumab and photodynamic therapy for polypoidal choroidal vasculopathy. Am J Ophthalmol. 2013;156:95-105.e1 pubmed publisher
    ..To determine the optimal time for administration of intravitreal ranibizumab injections before photodynamic therapy (PDT) as combined therapy to treat polypoidal choroidal vasculopathy (PCV)...
  38. Ohno Matsui K, Akiba M, Moriyama M, Ishibashi T, Hirakata A, Tokoro T. Intrachoroidal cavitation in macular area of eyes with pathologic myopia. Am J Ophthalmol. 2012;154:382-93 pubmed publisher
    ..To determine the incidence and characteristics of intrachoroidal cavitations in the macular area of eyes with high myopia...
  39. Loo A, Fitt A, Ramchandani M, Kirkby G. Pars plana vitrectomy with silicone oil in the management of combined rhegmatogenous retinal and choroidal detachment. Eye (Lond). 2001;15:612-5 pubmed
    ..This study was designed to determine the efficacy of pars plana vitrectomy with silicone oil injection in the management of this very difficult vitreoretinal problem...
  40. Ghoraba H. Primary vitrectomy for the management of rhegmatogenous retinal detachment associated with choroidal detachment. Graefes Arch Clin Exp Ophthalmol. 2001;239:733-6 pubmed
    ..To evaluate the role and the results of primary vitrectomy in treating cases with coexisting rhegmatogenous retinal detachment and choroidal detachment...
  41. Bouzas E, Karadimas P, Pournaras C. Central serous chorioretinopathy and glucocorticoids. Surv Ophthalmol. 2002;47:431-48 pubmed
    ..Glucocorticoids should not be used in the treatment of central serous chorioretinopathy and central serous chorioretinopathy should be added to the list of ocular complications of glucocorticoids...
  42. Silva R, Figueira J, Cachulo M, Duarte L, Faria de Abreu J, Cunha Vaz J. Polypoidal choroidal vasculopathy and photodynamic therapy with verteporfin. Graefes Arch Clin Exp Ophthalmol. 2005;243:973-9 pubmed
  43. Okubo A, Ito M, Sameshima M, Uemura A, Sakamoto T. Pulsatile blood flow in the polypoidal choroidal vasculopathy. Ophthalmology. 2005;112:1436-41 pubmed
    ..To describe patients with pulsatile polypoidal vessels in polypoidal choroidal vasculopathy (PCV)...
  44. Akaza E, Yuzawa M, Matsumoto Y, Kashiwakura S, Fujita K, Mori R. Role of photodynamic therapy in polypoidal choroidal vasculopathy. Jpn J Ophthalmol. 2007;51:270-7 pubmed
    ..To determine the efficacy of photodynamic therapy (PDT) with verteporfin for polypoidal choroidal vasculopathy (PCV)...
  45. Okubo A, Hirakawa M, Ito M, Sameshima M, Sakamoto T. Clinical features of early and late stage polypoidal choroidal vasculopathy characterized by lesion size and disease duration. Graefes Arch Clin Exp Ophthalmol. 2008;246:491-9 pubmed
    ..These differences might be partly attributable to the influence of the disease stage. We therefore evaluated the clinical features of early and late stage PCV...
  46. Akaza E, Mori R, Yuzawa M. Long-term results of photodynamic therapy of polypoidal choroidal vasculopathy. Retina. 2008;28:717-22 pubmed publisher
    ..This study evaluated the results of photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV) 24 months or more after treatment...
  47. Levecq L, De Potter P. Solitary choroidal tuberculoma in an immunocompetent patient. Arch Ophthalmol. 2005;123:864-6 pubmed
  48. Maruko I, Iida T, Saito M, Nagayama D, Saito K. Clinical characteristics of exudative age-related macular degeneration in Japanese patients. Am J Ophthalmol. 2007;144:15-22 pubmed
    ..To clarify the clinical characteristics of exudative age-related macular degeneration (AMD) in Japanese patients...
  49. Yuzawa M, Mori R, Kawamura A. The origins of polypoidal choroidal vasculopathy. Br J Ophthalmol. 2005;89:602-7 pubmed
    ..This study aims to improve imaging, using confocal scanning laser ophthalmoscopy (SLO), to elucidate the pathogenesis of PCV...
  50. Matsuoka M, Ogata N, Otsuji T, Nishimura T, Takahashi K, Matsumura M. Expression of pigment epithelium derived factor and vascular endothelial growth factor in choroidal neovascular membranes and polypoidal choroidal vasculopathy. Br J Ophthalmol. 2004;88:809-15 pubmed
    ..In addition, to compare the expression of PEDF with that of vascular endothelial growth factor (VEGF), a known stimulator of angiogenesis, in these tissues...
  51. Ciardella A, Donsoff I, Huang S, Costa D, Yannuzzi L. Polypoidal choroidal vasculopathy. Surv Ophthalmol. 2004;49:25-37 pubmed
  52. Quaranta M, Mauget Faysse M, Coscas G. Exudative idiopathic polypoidal choroidal vasculopathy and photodynamic therapy with verteporfin. Am J Ophthalmol. 2002;134:277-80 pubmed
    ..To report two cases of exudative idiopathic polypoidal choroidal vasculopathy treated by photodynamic therapy with verteporfin...
  53. Sim D, Sheth H, Kaines A, Tufail A. Punctate inner choroidopathy-associated choroidal neovascular membranes during pregnancy. Eye (Lond). 2008;22:725-7 pubmed publisher
    ..We present three cases of PIC-associated choroidal neovascular membrane (CNVM) occurring during pregnancy, and discuss associated investigative and treatment dilemmas...