retinitis

Summary

Summary: Inflammation of the RETINA. It is rarely limited to the retina, but is commonly associated with diseases of the choroid (CHORIORETINITIS) and of the OPTIC DISK (neuroretinitis).

Top Publications

  1. Reddy S, Cunningham E, Spaide R. Syphilitic retinitis with focal inflammatory accumulations. Ophthalmic Surg Lasers Imaging. 2006;37:429-31 pubmed
    ..after initiating a highly active antiretroviral therapy regimen was referred to rule out cytomegalo-virus retinitis. He had an unusual juxtapapillary collection of white superficial material and multiple preretinal collections ..
  2. de Amorim Garcia C, Gomes A, de Oliveira A. Bilateral stellar neuroretinitis in a patient with dengue fever. Eye (Lond). 2006;20:1382-3 pubmed
  3. Calder C, Nicholson L, Dick A. A selective role for the TNF p55 receptor in autocrine signaling following IFN-gamma stimulation in experimental autoimmune uveoretinitis. J Immunol. 2005;175:6286-93 pubmed
  4. Smith J, Verwaerde C, Rolling F, Naud M, Delanoye A, Thillaye Goldenberg B, et al. Tetracycline-inducible viral interleukin-10 intraocular gene transfer, using adeno-associated virus in experimental autoimmune uveoretinitis. Hum Gene Ther. 2005;16:1037-46 pubmed
    ..Our results show that local intravitreal injection of AAV2/2 is an effective means by which to deliver immunoregulatory molecules into the eye during uveitis, a chronic human ocular disease...
  5. Uemura A, Yashiro S, Takeda N, Oka S. [Ocular complications in patients with human immunodeficiency virus infection]. Nippon Ganka Gakkai Zasshi. 2006;110:698-702 pubmed
    ..To evaluate the recent clinical manifestations of ocular complications in patients with human immunodeficiency virus(HIV) infection...
  6. Shukla J, Saxena D, Rathinam S, Lalitha P, Joseph C, Sharma S, et al. Molecular detection and characterization of West Nile virus associated with multifocal retinitis in patients from southern India. Int J Infect Dis. 2012;16:e53-9 pubmed publisher
    ..Blood samples from affected patients were sent for clinical analysis to determine the actual cause of the illness, but reports were inconclusive...
  7. Chen M, Copland D, Zhao J, Liu J, Forrester J, Dick A, et al. Persistent inflammation subverts thrombospondin-1-induced regulation of retinal angiogenesis and is driven by CCR2 ligation. Am J Pathol. 2012;180:235-45 pubmed publisher
    ..This model offers a new platform to dissect the molecular and cellular pathology of inflammation-induced ocular angiogenesis...
  8. Spital G, Heiligenhaus A, Scheider A, Pauleikhoff D, Herbort C. ["White dot syndromes" in childhood]. Klin Monbl Augenheilkd. 2007;224:500-6 pubmed
    ..They were first described a few decades ago and our knowledge about these variable diseases is very limited, especially in regard to their overall incidence and their differential diagnostic relevance in uveitis of childhood...
  9. Xu H, Koch P, Chen M, Lau A, Reid D, Forrester J. A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images. Exp Eye Res. 2008;87:319-26 pubmed publisher

More Information

Publications62

  1. Copland D, Wertheim M, Armitage W, Nicholson L, Raveney B, Dick A. The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation. Invest Ophthalmol Vis Sci. 2008;49:5458-65 pubmed publisher
  2. Goldbaum M, Falkenstein I, Kozak I, Hao J, Bartsch D, Sejnowski T, et al. Analysis with support vector machine shows HIV-positive subjects without infectious retinitis have mfERG deficiencies compared to normal eyes. Trans Am Ophthalmol Soc. 2008;106:196-204; discussion 204-5 pubmed
    ..We applied a supervised MLC, SVM, to determine if mfERGs in eyes from patients with HIV differ from mfERGs in HIV-negative controls...
  3. Xu H, Manivannan A, Jiang H, Liversidge J, Sharp P, Forrester J, et al. Recruitment of IFN-gamma-producing (Th1-like) cells into the inflamed retina in vivo is preferentially regulated by P-selectin glycoprotein ligand 1:P/E-selectin interactions. J Immunol. 2004;172:3215-24 pubmed
    ..We suggest that random trafficking of activated T cells (both Th1 and Th2) across the blood-retina barrier is mediated by CD44:CD44R and LFA-1:ICAM-1, whereas preferential recruitment of Th1 cells is mediated by PSGL-1:P/E-selectin...
  4. Balayre S, Gomez K, Tribut A, Dore P, Gobert F. [Toxoplasma gondii and necrotizing retinitis: a case report]. J Fr Ophtalmol. 2003;26:837-41 pubmed
    ..It may present as diffuse necrotizing retinitis instead of a focal lesion...
  5. Chau Tran T, Cassoux N, Bodaghi B, Lehoang P. Successful treatment with combination of systemic antiviral drugs and intravitreal ganciclovir injections in the management of severe necrotizing herpetic retinitis. Ocul Immunol Inflamm. 2003;11:141-4 pubmed
    ..To report the use of intravenous (IV) antiviral agents and intravitreal ganciclovir injections in three immunocompetent patients with severe acute retinal necrosis (ARN)...
  6. Samuel M, Equi R, Chang T, Mieler W, Jampol L, Hay D, et al. Idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN): new observations and a proposed staging system. Ophthalmology. 2007;114:1526-1529.e1 pubmed
    To review the clinical features, disease progression, and effects of treatment on idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN).
  7. Zhang M, Xin H, Roon P, Atherton S. Infection of retinal neurons during murine cytomegalovirus retinitis. Invest Ophthalmol Vis Sci. 2005;46:2047-55 pubmed
    ..The purposes of this study were to identify which retinal neurons are infected and to determine the routes by which MCMV spreads in the retina...
  8. Falkenstein I, Bartsch D, Azen S, Dustin L, Sadun A, Freeman W. Multifocal electroretinography in HIV-positive patients without infectious retinitis. Am J Ophthalmol. 2008;146:579-88 pubmed publisher
    To evaluate early changes in the central retinal response in human immunodeficiency virus (HIV)-positive patients without infectious retinitis using multifocal electroretinography (mfERG).
  9. Kerr E, Raveney B, Copland D, Dick A, Nicholson L. Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations. J Autoimmun. 2008;31:354-61 pubmed publisher
    ..Instead, fluctuations in infiltrating leukocyte numbers and changes to their relative composition continue, indicating that clinical recovery does not equate to the restoration of a normal retinal leukocyte population...
  10. Mahesh G, Giridhar A, Shedbele A, Kumar R, Saikumar S. A case of bilateral presumed chikungunya neuroretinitis. Indian J Ophthalmol. 2009;57:148-50 pubmed
    ..There was bilateral neuroretinitis with peripapillary cotton wool spots. These findings should be kept in mind as an ocular manifestation of chikungunya virus infection...
  11. Sun M, Yang P, Du L, Zhou H, Ren X, Kijlstra A. Contribution of CD4+CD25+ T cells to the regression phase of experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci. 2010;51:383-9 pubmed publisher
    ..To investigate the role of CD4(+)CD25(+) Treg cells in the development of experimental autoimmune uveoretinitis (EAU)...
  12. Fu E, Geraets R, Dodds E, Echandi L, Colombero D, McDonald H, et al. Superficial retinal precipitates in patients with syphilitic retinitis. Retina. 2010;30:1135-43 pubmed publisher
    The purpose of this study was to describe the occurrence of superficial retinal precipitates in patients with syphilitic retinitis.
  13. Humbert G, Delettre C, Sénéchal A, Bazalgette C, Barakat A, Bazalgette C, et al. Homozygous deletion related to Alu repeats in RLBP1 causes retinitis punctata albescens. Invest Ophthalmol Vis Sci. 2006;47:4719-24 pubmed
    b>Retinitis punctata albescens (RPA) is an infrequently occurring form of autosomal recessive (and rarely dominant) retinal dystrophy featuring early-onset severe night blindness and tiny, dotlike, white deposits in the fundus...
  14. Tian L, Yang P, Lei B, Shao J, Wang C, Xiang Q, et al. AAV2-mediated subretinal gene transfer of hIFN-? attenuates experimental autoimmune uveoretinitis in mice. PLoS ONE. 2011;6:e19542 pubmed publisher
    ..In this study, we investigated the effectiveness of adeno-associated virus 2 (AAV2) based human interferon-alpha (hIFN-?) gene therapy in experimental autoimmune uveoretinitis (EAU), a classic model for human uveitis...
  15. Falkenstein I, Kozak I, Kayikcioglu O, Cheng L, Bartsch D, Azen S, et al. Assessment of retinal function in patients with HIV without infectious retinitis by multifocal electroretinogram and automated perimetry. Retina. 2006;26:928-34 pubmed
    To determine if multifocal electroretinogram (mfERG) testing shows abnormalities that correspond to perimetric defects in HIV positive patients without infectious retinitis.
  16. Murthy K, Venkataraman N, Satish V, Babu K. Bilateral retinitis following chikun- gunya fever. Indian J Ophthalmol. 2008;56:329-31 pubmed
    ..A diagnosis of neuroretinitis was made in the right eye while left eye showed features of retinitis. ELISA (serum) and polymerase chain reaction (aqueous) were positive for herpes simplex virus...
  17. Zhou J, Zhang M, Atherton S. Tumor necrosis factor-alpha-induced apoptosis in murine cytomegalovirus retinitis. Invest Ophthalmol Vis Sci. 2007;48:1691-700 pubmed
    Previous results suggest that apoptosis is involved in the pathogenesis of murine cytomegalovirus (MCMV) retinitis. To explore the mechanism underlying retinal apoptosis in MCMV retinitis, this study was initiated to determine whether ..
  18. Mahendradas P, Ranganna S, Shetty R, Balu R, Narayana K, Babu R, et al. Ocular manifestations associated with chikungunya. Ophthalmology. 2008;115:287-91 pubmed
    ..To report ocular manifestations associated with chikungunya...
  19. Anshu A, Chee S. Diffuse unilateral subacute neuroretinitis. Int Ophthalmol. 2008;28:127-9 pubmed
    ..We report a case of presumed DUSN to illustrate this diagnostic dilemma and to highlight the clinical signs which suggest the diagnosis...
  20. Yoshimura T, Sonoda K, Miyazaki Y, Iwakura Y, Ishibashi T, Yoshimura A, et al. Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis. Int Immunol. 2008;20:209-14 pubmed
    ..Taken together, our data demonstrated that IL-17/T(h)17 participates in the late phases of EAU and also that T(h)1 and T(h)17 responses are differentially required for EAU...
  21. Copland D, Liu J, Schewitz Bowers L, Brinkmann V, Anderson K, Nicholson L, et al. Therapeutic dosing of fingolimod (FTY720) prevents cell infiltration, rapidly suppresses ocular inflammation, and maintains the blood-ocular barrier. Am J Pathol. 2012;180:672-81 pubmed publisher
    ..These results support a strong therapeutic potential for fingolimod as an acute rescue therapy for the treatment of ocular immune-mediated inflammation...
  22. Wickremasinghe S, Ling C, Stawell R, Yeoh J, Hall A, Zamir E. Syphilitic punctate inner retinitis in immunocompetent gay men. Ophthalmology. 2009;116:1195-200 pubmed publisher
    ..To describe the features of an unusual syphilitic uveitis syndrome in a cluster of homosexual patients...
  23. Raveney B, Copland D, Dick A, Nicholson L. TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis. J Immunol. 2009;183:2321-9 pubmed publisher
    ..Thus, in TNFR1 knock out mice, the amplification of autoimmunity is limited, leading to resistance to experimental autoimmune uveoretinitis induction...
  24. Sun M, Yang P, Du L, Zhou H, Ren X, Lin X, et al. Increased Regulatory T Cells in Spleen during Experimental Autoimmune Uveoretinitis. Ocul Immunol Inflamm. 2010;18:38-43 pubmed publisher
    ..To investigate the role of Foxp3-positive regulatory T cells in the development of experimental autoimmune uveoretinitis (EAU)...
  25. Sun M, Yang Y, Yang P, Lei B, Du L, Kijlstra A. Regulatory effects of IFN-? on the development of experimental autoimmune uveoretinitis in B10RIII mice. PLoS ONE. 2011;6:e19870 pubmed publisher
    ..IFN-? has been used in the treatment of certain autoimmune diseases. Earlier studies showed that it ameliorated EAU; however, the mechanisms involved in this inhibition are still largely unknown...
  26. Gadjanski I, Williams S, Hein K, Sättler M, Bahr M, Diem R. Correlation of optical coherence tomography with clinical and histopathological findings in experimental autoimmune uveoretinitis. Exp Eye Res. 2011;93:82-90 pubmed publisher
    ..Indeed, significant differences in RT between different stages of EAU suggest that this OCT parameter is a sensitive marker for distinguishing disease phases in vivo...
  27. Davis J. Diagnostic dilemmas in retinitis and endophthalmitis. Eye (Lond). 2012;26:194-201 pubmed publisher
  28. Myint K, Sahay R, Mon S, Saravanan V, Narendran V, Dhillon B. "Worm in the eye": the rationale for treatment of DUSN in south India. Br J Ophthalmol. 2006;90:1125-7 pubmed
    ..To discuss the rationale for different techniques of treatment for DUSN (diffuse unilateral subacute neuroretinitis) and their effectiveness in two patients from south India...
  29. Xu H, Manivannan A, Dawson R, Crane I, Mack M, Sharp P, et al. Differentiation to the CCR2+ inflammatory phenotype in vivo is a constitutive, time-limited property of blood monocytes and is independent of local inflammatory mediators. J Immunol. 2005;175:6915-23 pubmed
  30. Balansard B, Bodaghi B, Cassoux N, Fardeau C, Romand S, Rozenberg F, et al. Necrotising retinopathies simulating acute retinal necrosis syndrome. Br J Ophthalmol. 2005;89:96-101 pubmed
    ..To determine an aetiological diagnosis in patients presenting with necrotising retinopathies that simulate acute retinal necrosis (ARN)...
  31. Garcia C, Gomes A, Garcia Filho C, Vianna R. Early-stage diffuse unilateral subacute neuroretinitis: improvement of vision after photocoagulation of the worm. Eye (Lond). 2004;18:624-7 pubmed
    ..To evaluate the visual outcome after direct laser photocoagulation of the worm in patients with early-stage diffuse unilateral subacute neuroretinitis (DUSN)...
  32. Cross S, Salomao D, Parisi J, Kryzer T, Bradley E, Mines J, et al. Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. Ann Neurol. 2003;54:38-50 pubmed
    ..patients with CRMP-5-IgG and optic neuritis (aged 52-74 years; all smokers, 9 women), we documented coexisting retinitis in 5. None had CAR-IgG. Fifteen had subacute vision loss, swollen optic discs, and field defects...
  33. Crane I, Xu H, Manivannan A, McKillop Smith S, Lamont G, Wallace C, et al. Effect of anti-macrophage inflammatory protein-1alpha on leukocyte trafficking and disease progression in experimental autoimmune uveoretinitis. Eur J Immunol. 2003;33:402-10 pubmed
    ..Long-term anti-MIP-1alpha treatment also prevented decreased leukocyte velocity and reduced disease severity as measured clinically, histologically and in terms of blood-retina barrier breakdown...
  34. Dix R. Systemic murine cytomegalovirus infection of mice with retrovirus-induced immunodeficiency results in ocular infection but not retinitis. Ophthalmic Res. 1998;30:295-301 pubmed
    ..to the eye following intravenous inoculation and to cause infection of ocular tissues and necrotizing retinitis in C57BL/6 mice with retrovirus-induced immunodeficiency syndrome (MAIDS)...
  35. Bratt G, Hammarin A, Grandien M, Hedquist B, Nennesmo I, Sundelin B, et al. BK virus as the cause of meningoencephalitis, retinitis and nephritis in a patient with AIDS. AIDS. 1999;13:1071-5 pubmed
    ..JCV might cause progressive multifocal leucoencephalopathy, but although up to 60% of AIDS patients excrete BKV in the urine there have been few reports of BKV-related renal and/or neurological disease in AIDS...
  36. Song A, Dubovy S, Berrocal A, Murray T. Endogenous fungal retinitis in a patient with acute lymphocytic leukemia manifesting as uveitis and optic nerve lesion. Arch Ophthalmol. 2002;120:1754-6 pubmed
  37. Smith J, Cunningham E. Atypical presentations of ocular toxoplasmosis. Curr Opin Ophthalmol. 2002;13:387-92 pubmed
    ..occlusions, rhegmatogenous and serous retinal detachments, a unilateral pigmentary retinopathy mimicking retinitis pigmentosa, neuroretinitis and other forms of optic neuropathy, and scleritis...
  38. de Smet M, Meenken C, van den Horn G. Fomivirsen - a phosphorothioate oligonucleotide for the treatment of CMV retinitis. Ocul Immunol Inflamm. 1999;7:189-98 pubmed
    ..phosphorothioate oligonucleotide which, when injected into a human eye, is capable of inhibiting CMV retinitis. Its mode of action is consistent with an antisense mechanism...
  39. Suzuki J, Sakai J, Okada A, Takada E, Usui M, Mizuguchi J. Oral administration of interferon-beta suppresses experimental autoimmune uveoretinitis. Graefes Arch Clin Exp Ophthalmol. 2002;240:314-21 pubmed
    ..This study examined whether oral administration of IFN-beta is capable of modulating inflammation in experimental autoimmune uveoretinitis (EAU)...
  40. Kwak H, Yang Y, Pae H, Kim Y, Chung H. Exogenous nitric oxide inhibits experimental autoimmune uveoretinitis development in Lewis rats by modulation of the Th1-dependent immune response. Mol Cells. 2001;12:178-84 pubmed
    ..In conclusion, we show that the administration of NO suppresses EAU by altering the Th1/Th2 balance of inflammatory immune responses. We suggest that NO may be useful in the therapeutic control of autoimmune uveitis...
  41. Avichezer D, Silver P, Chan C, Wiggert B, Caspi R. Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype. Invest Ophthalmol Vis Sci. 2000;41:127-31 pubmed
    ..The present communication describes the characterization of an epitope contained in residues 1 to 20 of human IRBP that induces EAU in H-2b mice...
  42. Warren K, Goldstein E, Hung V, Koehler J, Richardson W. Use of retinal biopsy to diagnose Bartonella (formerly Rochalimaea) henselae retinitis in an HIV-infected patient. Arch Ophthalmol. 1998;116:937-40 pubmed
    A patient with the acquired immunodeficiency syndrome developed bilateral retinitis due to a Bartonella (formerly Rochalimaea) henselae infection...
  43. Wallace G, Whiston R, Stanford M, Wells G, Gearing A, Clements J. The matrix metalloproteinase inhibitor BB-1101 prevents experimental autoimmune uveoretinitis (EAU). Clin Exp Immunol. 1999;118:364-70 pubmed
    ..These enzymes are produced by activated leucocytes and act on components of the basement membrane. These results therefore implicate these MMP as integral to the development of pathology in EAU...
  44. Kerkhoff F, Bergmans A, van der Zee A, Rothova A. Demonstration of Bartonella grahamii DNA in ocular fluids of a patient with neuroretinitis. J Clin Microbiol. 1999;37:4034-8 pubmed
    ..This is the first report that demonstrates the presence of a Bartonella species in the intraocular fluids of a nonimmunocompromised patient and that indicates that B. grahamii is pathogenic for humans...
  45. Okada A, Keino H, Fukai T, Sakai J, Usui M, Mizuguchi J. Effect of type I interferon on experimental autoimmune uveoretinitis in rats. Ocul Immunol Inflamm. 1998;6:215-26 pubmed
    ..These results indicate that systemic administration of IFN-alpha/beta suppresses IRBP-induced EAU in rats, and suggest that such suppression may be mediated in part by a reduction in TNF-alpha production...
  46. Haamann P, Kessel L, Larsen M. Monofocal outer retinitis associated with hand, foot, and mouth disease caused by coxsackievirus. Am J Ophthalmol. 2000;129:552-3 pubmed
    To report symptoms and signs from an otherwise healthy man with photopsia and monofocal outer retinitis occurring 3 days after the onset of hand, foot, and mouth disease.
  47. Chowdhury T, Jalali S, Majji A. Successful treatment of fungal retinitis and retinal vasculitis with oral itraconazole. Retina. 2002;22:800-2 pubmed
  48. Xu H, Manivannan A, Liversidge J, Sharp P, Forrester J, Crane I. Involvement of CD44 in leukocyte trafficking at the blood-retinal barrier. J Leukoc Biol. 2002;72:1133-41 pubmed
    ..These findings demonstrate that CD44 is directly involved in leukocyte-endothelial interaction in vivo and influence the trafficking of primed leukocytes to the retina and their overall survival...
  49. Madhavan H, Priya K. The diagnostic significance of enzyme linked immuno-sorbent assay for herpes simplex, varicella zoster and cytomegalovirus retinitis. Indian J Ophthalmol. 2003;51:71-5 pubmed
    ..to associate herpes simplex virus (HSV), varicella zoster virus (VZV) or cytomegalovirus (CMV) with viral retinitis as against polymerase chain reaction (PCR) on intraocular specimens...
  50. Maertzdorf J, Van der Lelij A, Baarsma G, Osterhaus A, Verjans G. Herpes simplex virus type 1 (HSV-1)--induced retinitis following herpes simplex encephalitis: indications for brain-to-eye transmission of HSV-1. Ann Neurol. 2001;49:104-6 pubmed
    ..The HSV-1 strains in both the brain and eye were identical in each patient, but they differed interindividually. The data suggest brain-to-eye transmission of HSV-1 in these patients...
  51. Labalette P, Bermond D, Dedes V, Savage C. Cat-scratch disease neuroretinitis diagnosed by a polymerase chain reaction approach. Am J Ophthalmol. 2001;132:575-6 pubmed
    ..To assess the value of polymerase chain reaction in the diagnosis of cat-scratch disease neuroretinitis without conclusive serology...
  52. Caspi R. Th1 and Th2 responses in pathogenesis and regulation of experimental autoimmune uveoretinitis. Int Rev Immunol. 2002;21:197-208 pubmed
  53. Yoshida S, Yoshida A, Ishibashi T, Elner S, Elner V. Role of MCP-1 and MIP-1alpha in retinal neovascularization during postischemic inflammation in a mouse model of retinal neovascularization. J Leukoc Biol. 2003;73:137-44 pubmed
    ..Our data suggest that MCP-1 and MIP-1alpha are involved in the induction of retinal neovascularization and play a role in the inflammation induced by the ischemic retinopathy, possibly by modulating or attracting macrophages/microglia...