geographic atrophy

Summary

Summary: A form of MACULAR DEGENERATION also known as dry macular degeneration marked by occurrence of a well-defined progressive lesion or atrophy in the central part of the RETINA called the MACULA LUTEA. It is distinguishable from WET MACULAR DEGENERATION in that the latter involves neovascular exudates.

Top Publications

  1. Merle B, Silver R, Rosner B, Seddon J. Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study. Am J Clin Nutr. 2016;103:1135-44 pubmed
    ..No effective therapeutic strategy for geographic atrophy (GA) is available, and prevention could be of great value...
  2. Tan A, Astroz P, Dansingani K, Slakter J, Yannuzzi L, Curcio C, et al. The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy. Invest Ophthalmol Vis Sci. 2017;58:2349-2358 pubmed publisher
    Histologic details of progression routes to geographic atrophy (GA) in AMD are becoming available through optical coherence tomography (OCT)...
  3. Curcio C, Zanzottera E, Ach T, Balaratnasingam C, Freund K. Activated Retinal Pigment Epithelium, an Optical Coherence Tomography Biomarker for Progression in Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017;58:BIO211-BIO226 pubmed publisher
    ..with clinical longitudinal eye-tracked SDOCT and with ex vivo imaging-histopathology correlations in geographic atrophy (GA) and pigment epithelium detachments (PED)...
  4. Ho A, Chang T, Samuel M, Williamson P, Willenbucher R, Malone T. Experience With a Subretinal Cell-based Therapy in Patients With Geographic Atrophy Secondary to Age-related Macular Degeneration. Am J Ophthalmol. 2017;179:67-80 pubmed publisher
    ..umbilical tissue-derived cells (palucorcel [CNTO-2476]) in the eyes of adults aged ?50 years with bilateral geographic atrophy (GA) secondary to age-related macular degeneration (AMD)...
  5. Dolz Marco R, Litts K, Tan A, Freund K, Curcio C. The Evolution of Outer Retinal Tubulation, a Neurodegeneration and Gliosis Prominent in Macular Diseases. Ophthalmology. 2017;124:1353-1367 pubmed publisher
    ..87 years (range, 56-96 years) met inclusion criteria. Of these 38 eyes, 23 (60%) had geographic atrophy secondary to age-related macular degeneration (AMD) and 2 eyes (5%) had geographic atrophy secondary to ..
  6. Dysli C, Fink R, Wolf S, Zinkernagel M. Fluorescence Lifetimes of Drusen in Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017;58:4856-4862 pubmed publisher
    ..Mean retinal autofluorescence lifetimes in AMD patients are significantly prolonged. Intraretinal deposits cause prolonged lifetimes, whereas deposits in the area of the outer photoreceptor segments lead to short fluorescence lifetimes. ..
  7. Laíns I, Miller J, Park D, Tsikata E, Davoudi S, Rahmani S, et al. Structural Changes Associated with Delayed Dark Adaptation in Age-Related Macular Degeneration. Ophthalmology. 2017;124:1340-1352 pubmed publisher
    ..Our results suggest a significant association between macular morphology evaluated by OCT and time to dark-adapt. Subretinal drusenoid deposits and ellipsoid zone changes seem to be strongly associated with impaired dark adaptation. ..
  8. Garg A, Blumberg D, Al Aswad L, Oll M, Yzer S, Forbes M, et al. Associations Between ?-Peripapillary Atrophy and Reticular Pseudodrusen in Early Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017;58:2810-2815 pubmed publisher
    ..Because ?-PPA is a common finding in NTG, focusing on a potential shared pathway between RPD and NTG could improve the understanding of pathophysiology and expand therapies for each condition. ..
  9. Merle B, Silver R, Rosner B, Seddon J. Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017;58:4569-4578 pubmed publisher
    ..Neovascular disease (NV) and geographic atrophy (GA) were evaluated separately...

More Information

Publications20

  1. Ferrara D, Silver R, Louzada R, Novais E, Collins G, Seddon J. Optical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017;58:3519-3529 pubmed publisher
    ..was used to evaluate univariate associations between features and progression to overall advanced AMD, geographic atrophy (GA), and neovascular disease (NV)...
  2. Cipriani V, Hogg R, Sofat R, Moore A, Webster A, Yates J, et al. Association of C-Reactive Protein Genetic Polymorphisms With Late Age-Related Macular Degeneration. JAMA Ophthalmol. 2017;135:909-916 pubmed publisher
    ..There were 1727 cases of late AMD (1151 neovascular, 384 geographic atrophy, and 192 mixed [neovascular AMD and geographic atrophy]) and 1153 controls...
  3. Edwards M, McLeod D, Bhutto I, Grebe R, Duffy M, Lutty G. Subretinal Glial Membranes in Eyes With Geographic Atrophy. Invest Ophthalmol Vis Sci. 2017;58:1352-1367 pubmed publisher
    ..This study evaluated the relationship between focal photoreceptors and RPE loss in geographic atrophy (GA) and Müller cell extension into the subretinal space...
  4. Corbelli E, Sacconi R, Rabiolo A, Mercuri S, Carnevali A, Querques L, et al. Optical Coherence Tomography Angiography in the Evaluation of Geographic Atrophy Area Extension. Invest Ophthalmol Vis Sci. 2017;58:5201-5208 pubmed publisher
    To investigate the application of optical coherence tomography angiography (OCT-A) in evaluation of geographic atrophy (GA) secondary to age-related macular degeneration (AMD)...
  5. Li H, Chintalapudi S, Jablonski M. Current drug and molecular therapies for the treatment of atrophic age-related macular degeneration: phase I to phase III clinical development. Expert Opin Investig Drugs. 2017;26:1103-1114 pubmed publisher
    ..Atrophic AMD, including early, intermediate and geographic atrophy (GA), accounts for ~90% of all cases...
  6. Evans J, Lawrenson J. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev. 2017;7:CD000254 pubmed publisher
    ..62, 95% CI 0.47 to 0.82; moderate-certainty evidence) and geographic atrophy (OR 0.75, 95% CI 0.51 to 1...
  7. Capuano V, Miere A, Querques L, Sacconi R, Carnevali A, Amoroso F, et al. Treatment-Naïve Quiescent Choroidal Neovascularization in Geographic Atrophy Secondary to Nonexudative Age-Related Macular Degeneration. Am J Ophthalmol. 2017;182:45-55 pubmed publisher
    To describe the characteristics and natural history of quiescent choroidal neovascularization (CNV) in geographic atrophy (GA) secondary to nonexudative age-related macular degeneration (AMD) through multimodal imaging...
  8. Pfau M, Goerdt L, Schmitz Valckenberg S, Mauschitz M, Mishra D, Holz F, et al. Green-Light Autofluorescence Versus Combined Blue-Light Autofluorescence and Near-Infrared Reflectance Imaging in Geographic Atrophy Secondary to Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017;58:BIO121-BIO130 pubmed publisher
    To compare the intermodality and interreader agreement for geographic atrophy (GA) lesion size quantification in green-light fundus autofluorescence (GAF; excitation = 518 nm) versus combined blue-light fundus autofluorescence (BAF; ..
  9. Lindner M, Nadal J, Mauschitz M, Lüning A, Czauderna J, Pfau M, et al. Combined Fundus Autofluorescence and Near Infrared Reflectance as Prognostic Biomarkers for Visual Acuity in Foveal-Sparing Geographic Atrophy. Invest Ophthalmol Vis Sci. 2017;58:BIO61-BIO67 pubmed publisher
    To identify predictors of best corrected visual acuity (BCVA) in eyes with foveal-sparing geographic atrophy (GA) secondary to age-related macular degeneration (AMD)...
  10. Sayegh R, Sacu S, Dunavölgyi R, Kroh M, Roberts P, Mitsch C, et al. Geographic Atrophy and Foveal-Sparing Changes Related to Visual Acuity in Patients With Dry Age-Related Macular Degeneration Over Time. Am J Ophthalmol. 2017;179:118-128 pubmed publisher
    To correlate the area of geographic atrophy (GA) and residual foveal sparing (FS), and to identify the minimum FS and maximum GA area allowing sufficient visual acuity (VA) for daily tasks. Prospective cohort study...
  11. Oishi M, Oishi A, Lindner M, Pfau M, Schmitz Valckenberg S, Holz F, et al. Structural Changes in Optical Coherence Tomography Underlying Spots of Increased Autofluorescence in the Perilesional Zone of Geographic Atrophy. Invest Ophthalmol Vis Sci. 2017;58:3303-3310 pubmed publisher
    ..corresponding to the appearance of increased fundus autofluorescence (FAF) in the perilesional area of geographic atrophy (GA) secondary to age-related macular degeneration...