retinal neovascularization

Summary

Summary: Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.

Top Publications

  1. Ameri H, Liu H, Liu R, Ha Y, Paulucci Holthauzen A, Hu S, et al. TWEAK/Fn14 pathway is a novel mediator of retinal neovascularization. Invest Ophthalmol Vis Sci. 2014;55:801-13 pubmed publisher
    b>Retinal neovascularization (NV) is a major cause of vision loss in ischemia-induced retinopathy...
  2. Håkansson J, Ståhlberg A, Wolfhagen Sand F, Gerhardt H, Semb H. N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy. PLoS ONE. 2011;6:e26026 pubmed publisher
    ..Neural cell adhesion molecule (N-CAM) is expressed by Müller cells and astrocytes, which are in close contact with the retinal vasculature, during normal developmental angiogenesis...
  3. Napp L, Augustynik M, Paesler F, Krishnasamy K, Woiterski J, Limbourg A, et al. Extrinsic Notch ligand Delta-like 1 regulates tip cell selection and vascular branching morphogenesis. Circ Res. 2012;110:530-5 pubmed publisher
    ..Tip cell differentiation is inhibited through lateral Notch signaling between ECs, which is controlled by Notch ligands expressed in vessel sprouts. The contribution of the Notch ligand Delta-like (Dll) 1 herein is unknown...
  4. Davies M, Stempel A, Hubert K, Powers M. Altered vascular expression of EphrinB2 and EphB4 in a model of oxygen-induced retinopathy. Dev Dyn. 2010;239:1695-707 pubmed publisher
    ..To understand how these molecules regulate retinal neovascularization (NV), we evaluated their expression in a model of oxygen-induced retinopathy (OIR)...
  5. Bai Y, Huang L, Xu X, Du W, Zhou A, Yu W, et al. Polyethylene glycol-modified pigment epithelial-derived factor: new prospects for treatment of retinal neovascularization. J Pharmacol Exp Ther. 2012;342:131-9 pubmed publisher
    Pathological retinal neovascularization and choroidal neovascularization are major causes of vision loss in a variety of clinical conditions, such as retinopathy of prematurity, age-related macular degeneration, and diabetic retinopathy...
  6. Steel D, Sandhu S. Submacular haemorrhages associated with neovascular age-related macular degeneration. Br J Ophthalmol. 2011;95:1051-7 pubmed publisher
    ..Using these techniques, outcomes better than the natural history have been achieved. This review aims to summarise what is known about SMH in nAMD and will discuss a variety of therapeutic interventions...
  7. Park S, Cho C, Jun H, Ryu N, Kim J, Yu Y, et al. Anti-angiogenic effect of luteolin on retinal neovascularization via blockade of reactive oxygen species production. Invest Ophthalmol Vis Sci. 2012;53:7718-26 pubmed publisher
    ..This study was performed to investigate the anti-angiogenic effect of luteolin against reactive oxygen species (ROS)-induced retinal neovascularization.
  8. Kataoka K, Nishiguchi K, Kaneko H, Van Rooijen N, Kachi S, Terasaki H. The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization. Invest Ophthalmol Vis Sci. 2011;52:1431-8 pubmed publisher
    ..To analyze the roles of vitreal macrophages and circulating leukocytes in retinal vascular growth...
  9. Roller A, Folk J, Patel N, Boldt H, Russell S, Abramoff M, et al. Intravitreal bevacizumab for treatment of proliferative and nonproliferative type 2 idiopathic macular telangiectasia. Retina. 2011;31:1848-55 pubmed publisher
    ..To determine the effect of treatment with intravitreal bevacizumab on retinal thickness and visual acuity in the nonproliferative and proliferative forms of Type 2 idiopathic macular telangiectasia...

More Information

Publications70

  1. Bai Y, Huang L, Zhou A, Zhao M, Yu W, Li X. Antiangiogenesis effects of endostatin in retinal neovascularization. J Ocul Pharmacol Ther. 2013;29:619-26 pubmed publisher
    ..In this study, we investigated the efficacy and potential mechanisms of endostatin for the prevention of retinal neovascularization both in vitro and in vivo.
  2. Zhang X, Huang X, Qiao J, Zhang J, Zhang M. Inhibition of hypoxia-induced retinal neovascularization in mice with short hairpin RNA targeting Rac1, possibly via blockading redox signaling. Exp Eye Res. 2011;92:473-81 pubmed publisher
    ..short hairpin RNA targeting Rac1 (Rac1-shRNA) to investigate the inhibitory effect on hypoxia-induced retinal neovascularization (RN) in vivo and the underlying mechanism...
  3. Yu W, Bai Y, Han N, Wang F, Zhao M, Huang L, et al. Inhibition of pathological retinal neovascularization by semaphorin 3A. Mol Vis. 2013;19:1397-405 pubmed
    ..Semaphorin 3A (Sema3A), a chemorepellent guidance protein, plays crucial roles in neural and vascular patterning. To identify its role in retinal neovascularization, we investigated its antiangiogenic effects.
  4. Vavilala D, O Bryhim B, Ponnaluri V, White R, Radel J, Symons R, et al. Honokiol inhibits pathological retinal neovascularization in oxygen-induced retinopathy mouse model. Biochem Biophys Res Commun. 2013;438:697-702 pubmed publisher
    Aberrant activation of the hypoxia inducible factor (HIF) pathway is the underlying cause of retinal neovascularization, one of the most common causes of blindness worldwide...
  5. Rakoczy E, Ali Rahman I, Binz N, Li C, Vagaja N, de Pinho M, et al. Characterization of a mouse model of hyperglycemia and retinal neovascularization. Am J Pathol. 2010;177:2659-70 pubmed publisher
    ..line not only retained the characteristics of the parental strains, such as developing hyperglycemia and retinal neovascularization, but developed higher blood glucose levels at a younger age and had worse kidney-body weight ratios than ..
  6. Zhang W, Yokota H, Xu Z, Narayanan S, Yancey L, Yoshida A, et al. Hyperoxia therapy of pre-proliferative ischemic retinopathy in a mouse model. Invest Ophthalmol Vis Sci. 2011;52:6384-95 pubmed publisher
    ..To investigate the therapeutic use and mechanisms of action of normobaric hyperoxia to promote revascularization and to prevent neovascularization in a mouse model of oxygen-induced ischemic retinopathy...
  7. Zhong X, Huang H, Shen J, Zacchigna S, Zentilin L, Giacca M, et al. Vascular endothelial growth factor-B gene transfer exacerbates retinal and choroidal neovascularization and vasopermeability without promoting inflammation. Mol Vis. 2011;17:492-507 pubmed
    ..The present study was conducted to evaluate the effect of overexpression of VEGF-B via adeno-associated virus (AAV) gene transfer on ocular angiogenesis, inflammation, and the blood-retinal barrier (BRB)...
  8. Palmer G, Tiran Z, Zhou Z, Capozzi M, Park W, Coletta C, et al. A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. Br J Pharmacol. 2012;165:1891-1903 pubmed publisher
    ..The angiopoietin (Ang)-Tie2 system plays critical roles in several steps of angiogenic remodelling. Here, we have investigated the anti-angiogenic effect of a novel angiopoietin-derived peptide...
  9. Lamoke F, Labazi M, Montemari A, Parisi G, Varano M, Bartoli M. Trans-Chalcone prevents VEGF expression and retinal neovascularization in the ischemic retina. Exp Eye Res. 2011;93:350-4 pubmed publisher
    b>Retinal neovascularization (RNV) is a critical pathological event and a major cause of blindness. Vascular inflammation and oxidative stress have been shown to play a key role in the induction and progression of RNV...
  10. Lim Y, Jo D, Kim J, Ahn J, Hwang Y, Kang D, et al. Human apolipoprotein(a) kringle V inhibits ischemia-induced retinal neovascularization via suppression of fibronectin-mediated angiogenesis. Diabetes. 2012;61:1599-608 pubmed publisher
    b>Retinal neovascularization is observed in progression of diabetic retinopathy. New vessels grow into the vitreous cavity in proliferative diabetic retinopathy, resulting in traction retinal detachment and vitreous hemorrhage...
  11. Xu Z, Gong J, Maiti D, Vong L, Wu L, Schwarz J, et al. MEF2C ablation in endothelial cells reduces retinal vessel loss and suppresses pathologic retinal neovascularization in oxygen-induced retinopathy. Am J Pathol. 2012;180:2548-60 pubmed publisher
    ..Both have two phases, vessel loss and consequent hypoxia-driven pathologic retinal neovascularization, yet relatively little is known about the transcription factors regulating these processes...
  12. Kong Y, Sun B, Zhao K, Han M, Wang Y. Small interference RNA targeting vascular endothelial growth factor gene effectively attenuates retinal neovascularization in mice model. Chin Med J (Engl). 2013;126:1440-4 pubmed
    The mechanism of retinal neovascularization is not understood completely...
  13. Nakamura S, Takizawa H, Shimazawa M, Hashimoto Y, Sugitani S, Tsuruma K, et al. Mild endoplasmic reticulum stress promotes retinal neovascularization via induction of BiP/GRP78. PLoS ONE. 2013;8:e60517 pubmed publisher
    ..into the intravitreal body of oxygen-induced retinopathy (OIR) model mice at postnatal day 14 (P14) and retinal neovascularization was quantified at P17...
  14. Xu H, Liu J, Xiong S, Le Y, Xia X. Suppression of retinal neovascularization by lentivirus-mediated netrin-1 small hairpin RNA. Ophthalmic Res. 2012;47:163-9 pubmed publisher
    The function of netrin-1 in pathological angiogenesis and its role in retinal neovascularization were investigated in the retinas of oxygen-induced retinopathy (OIR) mice by inhibition of netrin-1.
  15. Huang H, Van de Veire S, Dalal M, Parlier R, Semba R, Carmeliet P, et al. Reduced retinal neovascularization, vascular permeability, and apoptosis in ischemic retinopathy in the absence of prolyl hydroxylase-1 due to the prevention of hyperoxia-induced vascular obliteration. Invest Ophthalmol Vis Sci. 2011;52:7565-73 pubmed publisher
    ..These may be potential targets to reduce the complications of ischemic retinopathies...
  16. Fischer F, Martin G, Agostini H. Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy. J Neuroinflammation. 2011;8:120 pubmed publisher
    b>Retinal neovascularization has been intensively investigated in the mouse model of oxygen-induced retinopathy (OIR)...
  17. Wang F, Bai Y, Yu W, Han N, Huang L, Zhao M, et al. Anti-angiogenic effect of KH902 on retinal neovascularization. Graefes Arch Clin Exp Ophthalmol. 2013;251:2131-9 pubmed publisher
    ..This study was designed to examine the inhibitory effects of KH902 on mice with oxygen-induced retinopathy (OIR), one of the animal models of ROP...
  18. Li Z, He T, Du K, Xing Y, Yan Y, Chen Z, et al. Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression. Mol Vis. 2012;18:2847-59 pubmed
    ..The goal of our study was to investigate whether 15-LOX-1 plays a role in inhibiting retinal neovascularization (RNV) in a mouse model of oxygen-induced retinopathy (OIR) and the underlying mechanism.
  19. Oh E, Choi J, Kim H, Joo C, Hahn S. Anti-Flt1 peptide - hyaluronate conjugate for the treatment of retinal neovascularization and diabetic retinopathy. Biomaterials. 2011;32:3115-23 pubmed publisher
    ..Pharmacokinetic analysis confirmed the increased mean residence time of anti-Flt1 peptide after conjugation to HA longer than 2 weeks...
  20. Rouvas A, Papakostas T, Ntouraki A, Douvali M, Vergados I, Ladas I. Angiographic and OCT features of retinal angiomatous proliferation. Eye (Lond). 2010;24:1633-42; quiz 1643 pubmed publisher
    ..To propose a classification system for retinal angiomatous proliferation (RAP) on the basis of the indocyanine green angiography (ICG)...
  21. Tian X, Xia X, Xiong S, Jiang J, Liu D, Liu J. Netrin-1 overexpression in oxygen-induced retinopathy correlates with breakdown of the blood-retina barrier and retinal neovascularization. Ophthalmologica. 2011;226:37-44 pubmed publisher
    Recent research has shown netrin-1 to promote neovascularization. We evaluate the expression of netrin-1 during retinal neovascularization in a murine model of oxygen-induced retinopathy.
  22. Nakamura S, Morimoto N, Tsuruma K, Izuta H, Yasuda Y, Kato N, et al. Tissue kallikrein inhibits retinal neovascularization via the cleavage of vascular endothelial growth factor-165. Arterioscler Thromb Vasc Biol. 2011;31:1041-8 pubmed publisher
    ..To identify the role of tissue kallikrein in retinal neovascularization, we investigated the antiangiogenic effect by using an in vitro and in vivo angiogenesis model.
  23. Reche Frutos J, Calvo Gonzalez C, Pérez Trigo S, Fernandez Perez C, Donate Lopez J, Garcia Feijoo J. Ranibizumab in retinal angiomatous proliferation (RAP): influence of RAP stage on visual outcome. Eur J Ophthalmol. 2011;21:783-8 pubmed publisher
    ..To evaluate the influence of retinal angiomatous proliferation (RAP) stage on visual and anatomic outcome after ranibizumab (Lucentis®)...
  24. Bai Y, Bai X, Wang Z, Zhang X, Ruan C, Miao J. MicroRNA-126 inhibits ischemia-induced retinal neovascularization via regulating angiogenic growth factors. Exp Mol Pathol. 2011;91:471-7 pubmed publisher
    ..the potential transcriptional regulation and signal pathway of a single microRNA in ischemia-induced retinal neovascularization (NV), we used oxygen-induced retinopathy (OIR) in establishing retinal NV model, and quantitative real-..
  25. Ali Rahman I, Li C, Lai C, Rakoczy E. In vivo monitoring of VEGF-induced retinal damage in the Kimba mouse model of retinal neovascularization. Curr Eye Res. 2011;36:654-62 pubmed publisher
    ..To monitor retinal and vascular changes associated with neovascularization, which were generated through photoreceptor-specific overexpression of human vascular endothelial growth factor (hVEGF), in transgenic trVEGF029 (Kimba) mice...
  26. Singh N, Hansen D, Kundumani Sridharan V, Rao G. Both Kdr and Flt1 play a vital role in hypoxia-induced Src-PLD1-PKC?-cPLA(2) activation and retinal neovascularization. Blood. 2013;121:1911-23 pubmed publisher
    ..in mouse retina, and depletion of Kdr or Flt1 blocked hypoxia-induced Src-PLD1-PKC?-cPLA2 activation and retinal neovascularization. VEGFB induced Flt1 tyrosine phosphorylation and Src-PLD1-PKC?-cPLA2 activation in HRMVECs...
  27. Chintala H, Liu H, Parmar R, Kamalska M, Kim Y, Lovett D, et al. Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene. J Biol Chem. 2012;287:40570-85 pubmed publisher
    ..The role of connective tissue growth factor (CTGF/CCN2) in pathological angiogenesis in the retina is unknown...
  28. El Asrar A, Nawaz M, Kangave D, Geboes K, Ola M, Ahmad S, et al. High-mobility group box-1 and biomarkers of inflammation in the vitreous from patients with proliferative diabetic retinopathy. Mol Vis. 2011;17:1829-38 pubmed
    ..In addition, we examined the expression of HMGB1 in the retinas of diabetic mice...
  29. Zhou X, Wong L, Karakoti A, Seal S, McGinnis J. Nanoceria inhibit the development and promote the regression of pathologic retinal neovascularization in the Vldlr knockout mouse. PLoS ONE. 2011;6:e16733 pubmed publisher
    ..Our data demonstrate the unique ability of nanoceria to prevent downstream effects of oxidative stress in vivo and support their therapeutic potential for treatment of neurodegenerative diseases such as AMD and DR...
  30. Schmidinger G, Maar N, Bolz M, Scholda C, Schmidt Erfurth U. Repeated intravitreal bevacizumab (Avastin(®)) treatment of persistent new vessels in proliferative diabetic retinopathy after complete panretinal photocoagulation. Acta Ophthalmol. 2011;89:76-81 pubmed publisher
    ..To evaluate the effect of repeated intravitreal injections of bevacizumab (Avastin(®)) in patients with proliferative diabetic retinopathy and persistent new vessels after panretinal photocoagulation...
  31. El Sabagh H, Abdelghaffar W, Labib A, Mateo C, Hashem T, Al Tamimi D, et al. Preoperative intravitreal bevacizumab use as an adjuvant to diabetic vitrectomy: histopathologic findings and clinical implications. Ophthalmology. 2011;118:636-41 pubmed publisher
    ..To evaluate the effects of intervals between preoperative intravitreal injection of bevacizumab (IVB) and surgery on the components of removed diabetic fibrovascular proliferative membranes...
  32. Grossniklaus H, Kang S, Berglin L. Animal models of choroidal and retinal neovascularization. Prog Retin Eye Res. 2010;29:500-19 pubmed publisher
    There have been numerous types of animal models of choroidal neovascularization (CNV) and retinal neovascularization (RNV). Understanding the pathobiology of CNV and RNV is important when evaluating and utilizing these models...
  33. Pourgholami M, Khachigian L, Fahmy R, Badar S, Wang L, Chu S, et al. Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis. Biochem Biophys Res Commun. 2010;397:729-34 pubmed publisher
    ..In vivo albendazole profoundly inhibited hyperoxia-induced retinal angiogenesis in mice. These results provide new insights into the antiangiogenic effects of albendazole...
  34. Kamisasanuki T, Tokushige S, Terasaki H, Khai N, Wang Y, Sakamoto T, et al. Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis: a novel antiangiogenic therapy. Biochem Biophys Res Commun. 2011;413:128-35 pubmed publisher
    ..These results shed light on the biological roles of CD9 and may lead to novel antiangiogenic therapies...
  35. Kowluru R, Zhong Q, Santos J. Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9. Expert Opin Investig Drugs. 2012;21:797-805 pubmed publisher
  36. Van Geest R, Lesnik Oberstein S, Tan H, Mura M, Goldschmeding R, Van Noorden C, et al. A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy. Br J Ophthalmol. 2012;96:587-90 pubmed publisher
    ..This study investigated whether anti-VEGF agents induce accelerated fibrosis in patients with PDR, as predicted by this model...
  37. Zhang Q, Wang D, Kundumani Sridharan V, Gadiparthi L, Johnson D, Tigyi G, et al. PLD1-dependent PKCgamma activation downstream to Src is essential for the development of pathologic retinal neovascularization. Blood. 2010;116:1377-85 pubmed publisher
    ..In understanding the mechanisms of pathologic retinal neovascularization, we found that VEGF activates PLD1 in human retinal microvascular endothelial cells, and this event is ..
  38. Stahl A, Connor K, Sapieha P, Chen J, Dennison R, Krah N, et al. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 2010;51:2813-26 pubmed publisher
    ..From the multitude of studies performed in the mouse retina, a selection of representative works is discussed in more detail regarding their role in advancing the understanding of both the ocular and general mechanisms of angiogenesis...
  39. Kohno R, Hata Y, Mochizuki Y, Arita R, Kawahara S, Kita T, et al. Histopathology of neovascular tissue from eyes with proliferative diabetic retinopathy after intravitreal bevacizumab injection. Am J Ophthalmol. 2010;150:223-229.e1 pubmed publisher
    ..To examine the histopathologic effect of a single intravitreal injection of bevacizumab on newly formed vessels in eyes with proliferative diabetic retinopathy (PDR)...
  40. Kasai A, Ishimaru Y, Kinjo T, Satooka T, Matsumoto N, Yoshioka Y, et al. Apelin is a crucial factor for hypoxia-induced retinal angiogenesis. Arterioscler Thromb Vasc Biol. 2010;30:2182-7 pubmed publisher
    ..To investigate the role of endogenous apelin in pathological retinal angiogenesis...
  41. Jo D, Kim J, Kim J. How to overcome retinal neuropathy: the fight against angiogenesis-related blindness. Arch Pharm Res. 2010;33:1557-65 pubmed publisher
    ..In addition, because of the recent introduction of novel strategies, we describe pathogenesis-based treatment options to treat angiogenesis-related blindness...
  42. Nakamura S, Hayashi K, Takizawa H, Murase T, Tsuruma K, Shimazawa M, et al. An arylidene-thiazolidinedione derivative, GPU-4, without PPAR? activation, reduces retinal neovascularization. Curr Neurovasc Res. 2011;8:25-34 pubmed
    ..anti-angiogenic activity regarding human retinal microvascular endothelial cells (HRMECs) and retinal neovascularization in a mouse model of retinopathy of prematurity...
  43. Al Shabrawey M, Mussell R, Kahook K, Tawfik A, Eladl M, Sarthy V, et al. Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization. Diabetes. 2011;60:614-24 pubmed publisher
    ..The goal of this study was to investigate whether 12-LOX plays a role in retinal neovascularization (NV).
  44. Hua J, Guerin K, Chen J, Michan S, Stahl A, Krah N, et al. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci. 2011;52:2809-16 pubmed publisher
    ..low-density lipoprotein receptor mutant mice (Vldlr(-/-)) exhibit critical features of MacTel such as retinal neovascularization and photoreceptor degeneration...
  45. Chikaraishi Y, Shimazawa M, Hara H. New quantitative analysis, using high-resolution images, of oxygen-induced retinal neovascularization in mice. Exp Eye Res. 2007;84:529-36 pubmed
    Oxygen-induced retinopathy (OIR) has been widely studied as an animal model of retinal neovascularization diseases...
  46. Dioum E, Clarke S, Ding K, Repa J, Garcia J. HIF-2alpha-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery. Invest Ophthalmol Vis Sci. 2008;49:2714-20 pubmed publisher
    To characterize the effect of HIF-2alpha haploinsufficiency on retinal neovascularization and angiogenic signaling in neonatal mice...
  47. Akula J, Favazza T, Mocko J, Benador I, Asturias A, Kleinman M, et al. The anatomy of the rat eye with oxygen-induced retinopathy. Doc Ophthalmol. 2010;120:41-50 pubmed publisher
    ..The ratio of anterior to posterior axial-lengths ranged from 0.45 in controls through 0.37 in the 75 model to 0.32 in the 50/10 model. Thus, eye growth is altered in these rat models of ROP. ..
  48. Abu El Asrar A, Struyf S, Verbeke H, Van Damme J, Geboes K. Circulating bone-marrow-derived endothelial precursor cells contribute to neovascularization in diabetic epiretinal membranes. Acta Ophthalmol. 2011;89:222-8 pubmed publisher
    ..We investigated the presence of bone-marrow-derived endothelial precursor cells and the expression of the chemotactic pathway SDF-1 ?CXCL12)CXCR4 in PDR epiretinal membranes...
  49. Li B, Yin W, Hong X, Shi Y, Wang H, Lin S, et al. Remodeling retinal neovascularization by ALK1 gene transfection in vitro. Invest Ophthalmol Vis Sci. 2008;49:4553-60 pubmed publisher
    To explore a novel strategy for balancing retinal neovascularization by assessing the role activin-like kinase receptor 1 (ALK1) plays in neovascularization in vascular endothelial growth factor (VEGF)-stimulated human retinal capillary ..
  50. Ritter M, Banin E, Moreno S, Aguilar E, Dorrell M, Friedlander M. Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy. J Clin Invest. 2006;116:3266-76 pubmed
    ..with ischemic diseases such as retinopathy of prematurity and diabetic retinopathy are often due to retinal neovascularization. While significant progress has been made in the development of compounds useful for the treatment of ..
  51. Guaiquil V, Swendeman S, Yoshida T, Chavala S, Campochiaro P, Blobel C. ADAM9 is involved in pathological retinal neovascularization. Mol Cell Biol. 2009;29:2694-703 pubmed publisher
    ..Collectively, these results suggest that ADAM9 could be an attractive target for the prevention of proliferative retinopathies, CNV, and cancer. ..
  52. Mahmoud M, Allinson K, Zhai Z, Oakenfull R, Ghandi P, Adams R, et al. Pathogenesis of arteriovenous malformations in the absence of endoglin. Circ Res. 2010;106:1425-33 pubmed publisher
    ..Moreover, AVM formation appears to result from the combination of delayed vascular remodeling and an inappropriate endothelial cell proliferation response in the absence of endoglin. ..
  53. Lange C, Ehlken C, Stahl A, Martin G, Hansen L, Agostini H. Kinetics of retinal vaso-obliteration and neovascularisation in the oxygen-induced retinopathy (OIR) mouse model. Graefes Arch Clin Exp Ophthalmol. 2009;247:1205-11 pubmed publisher
  54. Berkowitz B, Roberts R. Evidence for a critical role of panretinal pathophysiology in experimental ROP. Doc Ophthalmol. 2010;120:13-24 pubmed publisher
    ..of retinopathy of prematurity, which were largely focused on the temporal and spatial links between retinal neovascularization (NV), vascular oxygenation, and intraretinal ion regulation...
  55. Dorrell M, Aguilar E, Jacobson R, Trauger S, Friedlander J, Siuzdak G, et al. Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy. Glia. 2010;58:43-54 pubmed publisher
    ..However, relatively little is known about the role of glial cells during pathological retinal neovascularization (NV), a leading contributor to vision loss in industrialized nations...
  56. Fletcher E, Downie L, Hatzopoulos K, Vessey K, Ward M, Chow C, et al. The significance of neuronal and glial cell changes in the rat retina during oxygen-induced retinopathy. Doc Ophthalmol. 2010;120:67-86 pubmed publisher
  57. Sarman S, Mancini J, van der Ploeg I, Croxatto J, Kvanta A, Gallo J. Involvement of purinergic P2 receptors in experimental retinal neovascularization. Curr Eye Res. 2008;33:285-91 pubmed publisher
    The present study was aimed to investigate the expression of purinergic P2 receptors in oxygen-induced retinal neovascularization.
  58. Sampaio R, Mendonca R, Simioni A, Costa R, Siqueira R, Correa V, et al. Rabbit retinal neovascularization induced by latex angiogenic-derived fraction: an experimental model. Curr Eye Res. 2010;35:56-62 pubmed publisher
    To create a retinal neovascularization experimental model using intravitreal injection of microspheres loaded with latex-derived angiogenic fraction.
  59. Yu W, Zou H, Li X, Yan Z, Dong J. Effects of the phosphatidylinositol 3-kinase inhibitor in a mouse model of retinal neovascularization. Ophthalmic Res. 2008;40:19-25 pubmed
    To determine the effects of LY294002, a phosphatidylinositol 3-kinase inhibitor, on suppressing experimental retinal neovascularization in an animal model of ischemic retinopathy.
  60. Berkowitz B, Roberts R, Penn J, Gradianu M. High-resolution manganese-enhanced MRI of experimental retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2007;48:4733-40 pubmed
    To test the hypothesis that in experimental retinopathy of prematurity (ROP), retinal neovascularization (NV) and vessel tortuosity have distinct spatial and temporal links with receptor and postreceptor ion demand.
  61. Arevalo J, Wu L, Sanchez J, Maia M, Saravia M, Fernandez C, et al. Intravitreal bevacizumab (Avastin) for proliferative diabetic retinopathy: 6-months follow-up. Eye (Lond). 2009;23:117-23 pubmed
    To study the effects of intravitreal bevacizumab (Avastin) on retinal neovascularization (RN) in patients with proliferative diabetic retinopathy (PDR).