Summary: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)

Top Publications

  1. Mokbel T, Khalaf M, El Khouly S, El Metwally N. Flexible Ahmed valve for selected cases of refractory glaucoma. Eur J Ophthalmol. 2012;22:83-9 pubmed publisher
    b>Glaucoma drainage implants are a useful alternative in treating glaucomas that are resistant to medical therapy and conventional glaucoma filtration surgery...
  2. Howell G, Soto I, Zhu X, Ryan M, Macalinao D, Sousa G, et al. Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma. J Clin Invest. 2012;122:1246-61 pubmed publisher
    b>Glaucoma is a common ocular disorder that is a leading cause of blindness worldwide. It is characterized by the dysfunction and loss of retinal ganglion cells (RGCs)...
  3. Joachim S, Gramlich O, Laspas P, Schmid H, Beck S, von Pein H, et al. Retinal ganglion cell loss is accompanied by antibody depositions and increased levels of microglia after immunization with retinal antigens. PLoS ONE. 2012;7:e40616 pubmed publisher
    Antibodies against retinal and optic nerve antigens are detectable in glaucoma patients...
  4. Mi X, Zhong J, Chang R, So K. Research advances on the usage of traditional Chinese medicine for neuroprotection in glaucoma. J Integr Med. 2013;11:233-40 pubmed publisher
    Progressive loss of retinal ganglion cells (RGCs) and their axons is the main pathogenesis of glaucoma. The cause of glaucoma is not fully understood, but the neurodegeneration of glaucoma involves many mechanisms such as oxidative stress,..
  5. Gramer E, Reiter C, Gramer G. Glaucoma and frequency of ocular and general diseases in 30 patients with aniridia: a clinical study. Eur J Ophthalmol. 2012;22:104-10 pubmed publisher patients with aniridia: age at first examination at the University Eye Hospital and age at diagnosis of glaucoma; visual acuity; frequency of family history of aniridia; and frequency of ocular and general diseases associated ..
  6. Rossi G, Pasinetti G, Scudeller L, Raimondi M, Lanteri S, Bianchi P. Risk factors to develop ocular surface disease ?in treated glaucoma or ocular hypertension patients. Eur J Ophthalmol. 2013;23:296-302 pubmed publisher
    ..To identify risk factors for developing ocular surface disease (OSD), to verify the prevalence of OSD, and to record efficacy of questionnaires in identifying symptoms' impact on patients' quality of life.?..
  7. De Groef L, Van Hove I, Dekeyster E, Stalmans I, Moons L. MMPs in the trabecular meshwork: promising targets for future glaucoma therapies?. Invest Ophthalmol Vis Sci. 2013;54:7756-63 pubmed publisher
    b>Glaucoma is one of the world's most common blinding diseases, affecting more than 60 million people worldwide...
  8. Rao H, Addepalli U, Yadav R, Senthil S, Choudhari N, Garudadri C. Effect of scan quality on diagnostic accuracy of spectral-domain optical coherence tomography in glaucoma. Am J Ophthalmol. 2014;157:719-27.e1 pubmed publisher
    ..evaluate the effect of scan quality on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) parameters of spectral-domain optical coherence tomography (SD OCT) in glaucoma.
  9. Leung C. Diagnosing glaucoma progression with optical coherence tomography. Curr Opin Ophthalmol. 2014;25:104-11 pubmed publisher
    ..fiber layer (RNFL), optic nerve head (ONH) and macula has gained popularity in recent years to detect and monitor glaucoma. With significant improvement in scan speed and scan resolution, spectral-domain OCT has become an efficient ..

More Information

Publications104 found, 100 shown here

  1. Hays C, Gulati V, Fan S, Samuelson T, Ahmed I, Toris C. Improvement in outflow facility by two novel microinvasive glaucoma surgery implants. Invest Ophthalmol Vis Sci. 2014;55:1893-900 pubmed publisher
    ..To determine improvement in outflow facility (C) in human anterior segments implanted with a novel Schlemm's canal scaffold or two trabecular micro-bypasses...
  2. Hu Y, Tan H, Wang X, Rong H, Cui H, Cui H. Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma. Clin Interv Aging. 2013;8:1467-70 pubmed publisher
    b>Glaucoma is a common eye disease in the aged population and has severe consequences...
  3. Carbonaro F, Hysi P, Fahy S, Nag A, Hammond C. Optic disc planimetry, corneal hysteresis, central corneal thickness, and intraocular pressure as risk factors for glaucoma. Am J Ophthalmol. 2014;157:441-6 pubmed publisher
    To determine whether corneal hysteresis and central corneal thickness are independent risk factors for glaucoma.
  4. He L, Yang H, Gardiner S, Williams G, Hardin C, Strouthidis N, et al. Longitudinal detection of optic nerve head changes by spectral domain optical coherence tomography in early experimental glaucoma. Invest Ophthalmol Vis Sci. 2014;55:574-86 pubmed publisher
    ..the detection of confocal scanning laser tomography (CSLT) ONH surface, SDOCT retinal nerve fiber layer (RNFL), scanning laser perimetry (SLP), and multifocal electroretinography (mfERG) change in eight experimental glaucoma (EG) eyes.
  5. Mwanza J, Warren J, Budenz D. Combining spectral domain optical coherence tomography structural parameters for the diagnosis of glaucoma with early visual field loss. Invest Ophthalmol Vis Sci. 2013;54:8393-400 pubmed publisher
    To create a multivariable predictive model for glaucoma with early visual field loss using a combination of spectral-domain optical coherence tomography (SD-OCT) parameters, and to compare the results with single variable models.
  6. Khawaja A, Chan M, Broadway D, Garway Heath D, Luben R, Yip J, et al. Corneal biomechanical properties and glaucoma-related quantitative traits in the EPIC-Norfolk Eye Study. Invest Ophthalmol Vis Sci. 2014;55:117-24 pubmed publisher
    We examined the association of corneal hysteresis (CH) with Heidelberg retina tomograph (HRT)- and Glaucoma Detection with Variable Corneal Compensation scanning laser polarimeter (GDxVCC)-derived measures in a British population...
  7. Sigal I, Grimm J, Jan N, Reid K, Minckler D, Brown D. Eye-specific IOP-induced displacements and deformations of human lamina cribrosa. Invest Ophthalmol Vis Sci. 2014;55:1-15 pubmed publisher
    ..To measure high-resolution eye-specific displacements and deformations induced within the human LC microstructure by an acute increase in IOP...
  8. Mwanza J, Budenz D, Godfrey D, Neelakantan A, Sayyad F, Chang R, et al. Diagnostic performance of optical coherence tomography ganglion cell--inner plexiform layer thickness measurements in early glaucoma. Ophthalmology. 2014;121:849-54 pubmed publisher
    To evaluate the glaucoma diagnostic performance of ganglion cell inner-plexiform layer (GCIPL) parameters used individually and in combination with retinal nerve fiber layer (RNFL) or optic nerve head (ONH) parameters measured with Cirrus ..
  9. Pérez de Lara M, Santano C, Guzman Aranguez A, Valiente Soriano F, Avilés Trigueros M, Vidal Sanz M, et al. Assessment of inner retina dysfunction and progressive ganglion cell loss in a mouse model of glaucoma. Exp Eye Res. 2014;122:40-9 pubmed publisher
    ..Our results indicate the existence of a correlation between retinal function impairment and RGC loss. This functional and morphological analysis allows a reliable assessment of the progression of the disease. ..
  10. Netland P, Sarkisian S, Moster M, Ahmed I, Condon G, Salim S, et al. Randomized, prospective, comparative trial of EX-PRESS glaucoma filtration device versus trabeculectomy (XVT study). Am J Ophthalmol. 2014;157:433-440.e3 pubmed publisher
    To compare the clinical outcomes of the EX-PRESS glaucoma filtration device placed under a partial-thickness scleral flap with trabeculectomy.
  11. Yoshikawa M, Akagi T, Hangai M, Ohashi Ikeda H, Takayama K, Morooka S, et al. Alterations in the neural and connective tissue components of glaucomatous cupping after glaucoma surgery using swept-source optical coherence tomography. Invest Ophthalmol Vis Sci. 2014;55:477-84 pubmed publisher
    To visualize changes in deep optic nerve head (ONH) structures following glaucoma surgery using (3-dimensional [3D]) swept-source optical coherence tomography (SS-OCT) and to determine the clinical and structural factors associated with ..
  12. Raza A, Zhang X, De Moraes C, Reisman C, Liebmann J, Ritch R, et al. Improving glaucoma detection using spatially correspondent clusters of damage and by combining standard automated perimetry and optical coherence tomography. Invest Ophthalmol Vis Sci. 2014;55:612-24 pubmed publisher
    To improve the detection of glaucoma, techniques for assessing local patterns of damage and for combining structure and function were developed.
  13. Nakano N, Ikeda H, Hangai M, Muraoka Y, Toda Y, Kakizuka A, et al. Longitudinal and simultaneous imaging of retinal ganglion cells and inner retinal layers in a mouse model of glaucoma induced by N-methyl-D-aspartate. Invest Ophthalmol Vis Sci. 2011;52:8754-62 pubmed publisher
    ..Simultaneous imaging of CFP expression in the RGCs and inner retinal layers provides a sensitive, reliable, and new method for longitudinal evaluation of progressive RGC damage in experimental models of glaucoma.
  14. Johnson T, Martin K. Cell transplantation approaches to retinal ganglion cell neuroprotection in glaucoma. Curr Opin Pharmacol. 2013;13:78-82 pubmed publisher
    b>Glaucoma is a complex neurodegenerative disease that involves interactions among multiple signaling pathways, ultimately leading to progressive retinal ganglion cell (RGC) death...
  15. Redmond T, Anderson R, Russell R, Garway Heath D. Relating retinal nerve fiber layer thickness and functional estimates of ganglion cell sampling density in healthy eyes and in early glaucoma. Invest Ophthalmol Vis Sci. 2013;54:2153-62 pubmed publisher
    ..acuity (PGRA) as well as differential light sensitivity (DLS) in healthy subjects and patients with early glaucoma. The agreement between estimates of retinal ganglion cell (GC) density from each functional test is explored...
  16. Lisboa R, Chun Y, Zangwill L, Weinreb R, Rosen P, Liebmann J, et al. Association between rates of binocular visual field loss and vision-related quality of life in patients with glaucoma. JAMA Ophthalmol. 2013;131:486-94 pubmed publisher
    ..To evaluate the association between binocular rates of visual field change and VRQOL in patients with glaucoma. DESIGN Observational cohort study...
  17. Rouse J, Sarkisian S. Mini-drainage devices: the Ex-PRESS Mini-Glaucoma Device. Dev Ophthalmol. 2012;50:90-5 pubmed publisher
    The Ex-PRESS Mini-Glaucoma Device is a glaucoma drainage device used to shunt aqueous from the anterior chamber into a subconjunctival reservoir that is created surgically...
  18. Bosco A, Crish S, Steele M, Romero C, Inman D, Horner P, et al. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PLoS ONE. 2012;7:e43602 pubmed publisher
    b>Glaucoma is a neurodegenerative disease that results in the progressive decline and ultimate death of retinal ganglion cells (RGCs)...
  19. Cull G, Burgoyne C, Fortune B, Wang L. Longitudinal hemodynamic changes within the optic nerve head in experimental glaucoma. Invest Ophthalmol Vis Sci. 2013;54:4271-7 pubmed publisher basal blood flow (BF) of the optic nerve head (ONH) during progression of structural damage in experimental glaucoma (EG)...
  20. Zhang Y, Chen X, Wen G, Wu G, Zhang X. Proton magnetic resonance spectroscopy ((1)H-MRS) reveals geniculocalcarine and striate area degeneration in primary glaucoma. PLoS ONE. 2013;8:e73197 pubmed publisher
    b>Glaucoma is a collection of neurodegenerative diseases that affect both the retina and the central visual pathway...
  21. Van Bergen T, Vandewalle E, Van de Veire S, Dewerchin M, Stassen J, Moons L, et al. The role of different VEGF isoforms in scar formation after glaucoma filtration surgery. Exp Eye Res. 2011;93:689-99 pubmed publisher
    ..that non-selective inhibition of VEGF by bevacizumab had a beneficial effect on surgical outcome after glaucoma filtration surgery by reducing angiogenesis as well as fibrosis...
  22. Coudrillier B, Tian J, Alexander S, Myers K, Quigley H, Nguyen T. Biomechanics of the human posterior sclera: age- and glaucoma-related changes measured using inflation testing. Invest Ophthalmol Vis Sci. 2012;53:1714-28 pubmed publisher
    The objective of this study was to measure the biomechanical response of the human posterior sclera in vitro and to estimate the effects of age and glaucoma.
  23. Dai Y, Sun X, Yu X, Guo W, Yu D. Astrocytic responses in the lateral geniculate nucleus of monkeys with experimental glaucoma. Vet Ophthalmol. 2012;15:23-30 pubmed publisher
    To investigate the responses of lateral geniculate nucleus (LGN) astrocytes to experimental glaucoma in monkeys. ? Rhesus monkeys (Macaca mulatta)...
  24. Lai J, Hsieh A. A gelatin-g-poly(N-isopropylacrylamide) biodegradable in situ gelling delivery system for the intracameral administration of pilocarpine. Biomaterials. 2012;33:2372-87 pubmed publisher
    ..In a rabbit glaucoma model, the performance of delivery carriers was evaluated by biomicroscopy, intraocular pressure (IOP), and pupil ..
  25. Morgan J. Retina ganglion cell degeneration in glaucoma: an opportunity missed? A review. Clin Exp Ophthalmol. 2012;40:364-8 pubmed publisher
    Retinal ganglion cell degeneration has been reported in a range of experimental models of glaucoma. Manifest as pruning of retinal ganglion cell dendrites, it is likely to influence both the function and viability of affected cells...
  26. Roh M, Zhang Y, Murakami Y, Thanos A, Lee S, Vavvas D, et al. Etanercept, a widely used inhibitor of tumor necrosis factor-? (TNF-?), prevents retinal ganglion cell loss in a rat model of glaucoma. PLoS ONE. 2012;7:e40065 pubmed publisher
    Visual loss in glaucoma is associated with pathological changes in retinal ganglion cell (RGC) axons and a slow decline in the RGC population...
  27. Fuchs M, Scholz M, Sendelbeck A, Atorf J, Schlegel C, Enz R, et al. Rod photoreceptor ribbon synapses in DBA/2J mice show progressive age-related structural changes. PLoS ONE. 2012;7:e44645 pubmed publisher
    The DBA/2J mouse is a commonly used animal model in glaucoma research. The eyes of DBA/2J mice show severe age-related changes that finally lead to the degeneration of retinal ganglion cells and the optic nerve...
  28. Rao H, Senthil S, Choudhari N, Mandal A, Garudadri C. Behavior of visual field index in advanced glaucoma. Invest Ophthalmol Vis Sci. 2013;54:307-12 pubmed publisher
    ..In a retrospective study, 37 stable glaucoma eyes in which MD of the VFs crossed -20 dB were identified...
  29. Hirashima T, Hangai M, Nukada M, Nakano N, Morooka S, Akagi T, et al. Frequency-doubling technology and retinal measurements with spectral-domain optical coherence tomography in preperimetric glaucoma. Graefes Arch Clin Exp Ophthalmol. 2013;251:129-37 pubmed publisher
    ..visual fields and retinal structures measured with spectral-domain optical coherence tomography in preperimetric glaucoma (PPG). Twenty-six eyes of 26 patients with PPG and 20 healthy eyes of 20 volunteers were included...
  30. Pijanka J, Coudrillier B, Ziegler K, Sorensen T, Meek K, Nguyen T, et al. Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae. Invest Ophthalmol Vis Sci. 2012;53:5258-70 pubmed publisher
    ..The posterior sclera has a major biomechanical influence on the optic nerve head, and may therefore be important in glaucoma. Scleral material properties are influenced significantly by collagen fiber architecture...
  31. Roughead E, Kalisch L, Pratt N, Killer G, Barnard A, Gilbert A. Managing glaucoma in those with co-morbidity: not as easy as it seems. Ophthalmic Epidemiol. 2012;19:74-82 pubmed publisher
    To identify the extent of use of medicines recommended to be used with caution in glaucoma patients with specified comorbidities and to determine evidence of associated harm...
  32. Soohoo J, Seibold L, Laing A, Kahook M. Bleb morphology and histology in a rabbit model of glaucoma filtration surgery using Ozurdex® or mitomycin-C. Mol Vis. 2012;18:714-9 pubmed
    To determine the effect of a sustained-release dexamethasone implant (Ozurdex(®)) on wound healing after glaucoma filtration surgery in a rabbit model...
  33. Marín Franch I, Malik R, Crabb D, Swanson W. Choice of statistical method influences apparent association between structure and function in glaucoma. Invest Ophthalmol Vis Sci. 2013;54:4189-96 pubmed publisher
    ..statistical methods may lead to inconsistent inferences about the association between structure and function in glaucoma. Two datasets from published studies were selected for their illustrative value...
  34. De Moraes C, Liebmann J, Park S, Teng C, Nemiroff J, Tello C, et al. Optic disc progression and rates of visual field change in treated glaucoma. Acta Ophthalmol. 2013;91:e86-91 pubmed publisher
    ..the relationship between optic disc progression and rates of visual field (VF) change in patients with treated glaucoma. Glaucoma patients with repeatable VF loss, ?8 SITA-Standard 24-2 VF tests and good quality optic disc ..
  35. Fortune B, Burgoyne C, Cull G, Reynaud J, Wang L. Onset and progression of peripapillary retinal nerve fiber layer (RNFL) retardance changes occur earlier than RNFL thickness changes in experimental glaucoma. Invest Ophthalmol Vis Sci. 2013;54:5653-61 pubmed publisher
    ..A total of 41 rhesus macaques with unilateral experimental glaucoma (EG) each had three or more weekly baseline measurements in both eyes of peripapillary RNFL thickness (RNFLT) and ..
  36. Peng C, Burke M, Carbia B, Plummer C, Chauhan A. Extended drug delivery by contact lenses for glaucoma therapy. J Control Release. 2012;162:152-8 pubmed publisher
    ..timolol release studies and in vivo pharmacodynamics studies in beagle dogs to evaluate the efficacy of glaucoma therapy through extended wear contact lenses...
  37. Shields C, Shah S, Bianciotto C, Emrich J, Komarnicky L, Shields J. Iris melanoma management with iodine-125 plaque radiotherapy in 144 patients: impact of melanoma-related glaucoma on outcomes. Ophthalmology. 2013;120:55-61 pubmed publisher
    To evaluate the outcomes of iris melanoma managed with plaque radiotherapy on the basis of the initial presence or absence of glaucoma.
  38. Brignole Baudouin F, Desbenoit N, Hamm G, Liang H, Both J, Brunelle A, et al. A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits. PLoS ONE. 2012;7:e50180 pubmed publisher
    ..detected on the ocular surface structures, but also in deeper tissues, especially in sensitive areas involved in glaucoma pathophysiology, such as the trabecular meshwork and the optic nerve areas, as confirmed by images with ..
  39. Mathews P, Ramulu P, Friedman D, Utine C, Akpek E. Evaluation of ocular surface disease in patients with glaucoma. Ophthalmology. 2013;120:2241-8 pubmed publisher
    To evaluate the subjective and objective measures of ocular surface disease in patients with glaucoma. Cross-sectional study. Sixty-four glaucoma subjects with bilateral visual field (VF) loss and 59 glaucoma suspects with normal VFs...
  40. Kyari F, Abdull M, Bastawrous A, Gilbert C, Faal H. Epidemiology of glaucoma in sub-saharan Africa: prevalence, incidence and risk factors. Middle East Afr J Ophthalmol. 2013;20:111-25 pubmed publisher
    The purpose of this study is to review the epidemiology of different types of glaucoma relevant to Sub-Saharan Africa (SSA) and to discuss the evidence regarding the risk factors for onset and progression of glaucoma, including risk ..
  41. Crabb D, Garway Heath D. Intervals between visual field tests when monitoring the glaucomatous patient: wait-and-see approach. Invest Ophthalmol Vis Sci. 2012;53:2770-6 pubmed publisher
    ..Modeling experiments, as reported here, are useful for investigating and optimizing follow-up schemes. ..
  42. Medeiros F, Lisboa R, Weinreb R, Liebmann J, Girkin C, Zangwill L. Retinal ganglion cell count estimates associated with early development of visual field defects in glaucoma. Ophthalmology. 2013;120:736-44 pubmed publisher
    To estimate retinal ganglion cell (RGC) losses associated with the earliest development of visual field defects in glaucoma. Observational cohort study...
  43. Adekoya B, Akinsola F, Balogun B, Balogun M, Ibidapo O. Patient refusal of glaucoma surgery and associated factors in Lagos, Nigeria. Middle East Afr J Ophthalmol. 2013;20:168-73 pubmed publisher
    To determine the prevalence of patient refusal of glaucoma surgery (GSR) and the associated factors in Lagos, Nigeria. A multicenter cross-sectional survey was conducted in Lagos state, Nigeria...
  44. Seitz R, Ohlmann A, Tamm E. The role of Müller glia and microglia in glaucoma. Cell Tissue Res. 2013;353:339-45 pubmed publisher
    Cells of Müller glia and microglia react to neuronal injury in glaucoma. The change to a reactive phenotype initiates signaling cascades that may serve a neuroprotective role, but may also proceed to promote damaging effects on retinal ..
  45. Rüfer F, Erb C. [Influence of dry eye syndrome on glaucoma diagnostic procedures]. Ophthalmologe. 2012;109:1082-6 pubmed publisher
    Approximately 50-60% of primary open angle glaucoma patients suffer from dry eye and ocular surface disease and have a reduced corneal thickness...
  46. Ruddle J, Staffieri S, Crowston J, Sherwin J, Mackey D. Incidence and predictors of glaucoma following surgery for congenital cataract in the first year of life in Victoria, Australia. Clin Exp Ophthalmol. 2013;41:653-61 pubmed publisher
    To determine the incidence and predictors of glaucoma following surgery for congenital and infantile cataract in an Australian population.
  47. Na J, Sung K, Baek S, Kim Y, Durbin M, Lee H, et al. Detection of glaucoma progression by assessment of segmented macular thickness data obtained using spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53:3817-26 pubmed publisher
    We evaluated the clinical use of segmented macular layer thickness measurement in terms of glaucoma diagnosis and the ability to detect progression, and to compare such outcomes to those by circumpapillary retinal nerve fiber layer (..
  48. Minton A, Phatak N, Stankowska D, He S, Ma H, Mueller B, et al. Endothelin B receptors contribute to retinal ganglion cell loss in a rat model of glaucoma. PLoS ONE. 2012;7:e43199 pubmed publisher
    b>Glaucoma is an optic neuropathy, commonly associated with elevated intraocular pressure (IOP) characterized by optic nerve degeneration, cupping of the optic disc, and loss of retinal ganglion cells which could lead to loss of vision...
  49. Solus J, Jampel H, Tracey P, Gilbert D, Loyd T, Jefferys J, et al. Comparison of limbus-based and fornix-based trabeculectomy: success, bleb-related complications, and bleb morphology. Ophthalmology. 2012;119:703-11 pubmed publisher
    ..To compare the success and complications of trabeculectomy performed with limbus-based and fornix-based conjunctival approaches...
  50. Goel M, Sienkiewicz A, Picciani R, Wang J, Lee R, Bhattacharya S. Cochlin, intraocular pressure regulation and mechanosensing. PLoS ONE. 2012;7:e34309 pubmed publisher
    ..Taken together with previous studies, we show cochlin is involved in regulation of intraocular pressure in DBA/2J potentially through mechanosensing of the shear stress...
  51. Medeiros F, Zangwill L, Bowd C, Mansouri K, Weinreb R. The structure and function relationship in glaucoma: implications for detection of progression and measurement of rates of change. Invest Ophthalmol Vis Sci. 2012;53:6939-46 pubmed publisher
    To evaluate the relationship between change in estimated retinal ganglion cell (RGC) counts and change in measures of functional and structural damage in glaucoma, from cross-sectional data.
  52. Seymenoğlu G, Baser E, Oztürk B. Comparison of spectral-domain optical coherence tomography and Heidelberg retina tomograph III optic nerve head parameters in glaucoma. Ophthalmologica. 2013;229:101-5 pubmed publisher
    ..obtained by spectral-domain optical coherence tomography/scanning laser ophthalmoscope (SD-OCT/SLO) and the Heidelberg retinal tomograph III (HRT-III), and to compare the ONH measurements of both devices in different glaucoma types.
  53. Foxton R, Finkelstein A, Vijay S, Dahlmann Noor A, Khaw P, Morgan J, et al. VEGF-A is necessary and sufficient for retinal neuroprotection in models of experimental glaucoma. Am J Pathol. 2013;182:1379-90 pubmed publisher
    ..These results were confirmed in animal models of staurosporine-induced RGC death and experimental hypertensive glaucoma. Importantly, we observed that VEGF-A blockade significantly exacerbated neuronal cell death in the hypertensive ..
  54. Kersey T, Clement C, Bloom P, Cordeiro M. New trends in glaucoma risk, diagnosis & management. Indian J Med Res. 2013;137:659-68 pubmed
    ..have seen a surge of new ideas and technologies to aid in the detection, treatment and further understanding of glaucoma. These technologies and advances are discussed to provide information on risk-factors, diagnosis and treatment...
  55. Yang X, Luo C, Cai J, Powell D, Yu D, Kuehn M, et al. Neurodegenerative and inflammatory pathway components linked to TNF-?/TNFR1 signaling in the glaucomatous human retina. Invest Ophthalmol Vis Sci. 2011;52:8442-54 pubmed publisher
    This study aimed to determine retinal proteomic alterations in human glaucoma, with particular focus on links to TNF-?/TNFR1 signaling.
  56. Galdos M, Bayon A, Rodriguez F, Micó C, Sharma S, Vecino E. Morphology of retinal vessels in the optic disk in a Göttingen minipig experimental glaucoma model. Vet Ophthalmol. 2012;15 Suppl 1:36-46 pubmed publisher
    ..Present results were compared to human glaucoma findings.
  57. Landers J, Martin K, Sarkies N, Bourne R, Watson P. A twenty-year follow-up study of trabeculectomy: risk factors and outcomes. Ophthalmology. 2012;119:694-702 pubmed publisher
    ..This study was undertaken to determine the performance of trabeculectomy surgery over a 20-year period and examine the associations between outcome and risk factors for trabeculectomy failure...
  58. Calvo P, Ferreras A, Polo V, Güerri N, Seral P, Fuertes Lazaro I, et al. Predictive value of retrobulbar blood flow velocities in glaucoma suspects. Invest Ophthalmol Vis Sci. 2012;53:3875-84 pubmed publisher
    To determine whether retrobulbar blood flow (RBF) velocities are predictive of conversion to glaucoma.
  59. Georgiou A, Guo L, Cordeiro M, Salt T. Changes in the modulation of retinocollicular transmission through group III mGluRs long after an increase in intraocular pressure in a rat model of glaucoma. Vis Neurosci. 2012;29:237-46 pubmed
    ..In glaucoma, retinal ganglion cells (RGCs) degenerate, which may have an implication on this transmission as the superior ..
  60. Kotowski J, Folio L, Wollstein G, Ishikawa H, Ling Y, Bilonick R, et al. Glaucoma discrimination of segmented cirrus spectral domain optical coherence tomography (SD-OCT) macular scans. Br J Ophthalmol. 2012;96:1420-5 pubmed publisher
    To evaluate the glaucoma discriminating ability of macular retinal layers as measured by spectral domain optical coherence tomography (SD-OCT).
  61. Junoy Montolio F, Wesselink C, Gordijn M, Jansonius N. Factors that influence standard automated perimetry test results in glaucoma: test reliability, technician experience, time of day, and season. Invest Ophthalmol Vis Sci. 2012;53:7010-7 pubmed publisher
    To determine the influence of several factors on standard automated perimetry test results in glaucoma.
  62. Rouland J, Traverso C, Stalmans I, Fekih L, Delval L, Renault D, et al. Efficacy and safety of preservative-free latanoprost eyedrops, compared with BAK-preserved latanoprost in patients with ocular hypertension or glaucoma. Br J Ophthalmol. 2013;97:196-200 pubmed publisher
    ..intraocular pressure (IOP) reduction) and safety of preservative-free latanoprost (T2345) to benzalkonium chloride (BAK)-preserved latanoprost (BPL; Xalatan) in ocular hypertension (OHT) or primary open angle glaucoma (POAG) patients.
  63. GHISO J, Doudevski I, Ritch R, Rostagno A. Alzheimer's disease and glaucoma: mechanistic similarities and differences. J Glaucoma. 2013;22 Suppl 5:S36-8 pubmed publisher
    ..fully understood, research and clinical findings point to a possible common causal relationship between AD and glaucoma. These two chronic neurodegenerative disorders share biological and mechanistic features, among them (1) a strong ..
  64. Kanamori A, Naka M, Akashi A, Fujihara M, Yamada Y, Nakamura M. Cluster analyses of grid-pattern display in macular parameters using optical coherence tomography for glaucoma diagnosis. Invest Ophthalmol Vis Sci. 2013;54:6401-8 pubmed publisher
    Using spectral-domain optical coherence tomography (SD-OCT), we assessed the ability of cluster analyses, based on the grid-pattern of macular parameters, to detect glaucoma.
  65. Christakis P, Kalenak J, Zurakowski D, Tsai J, Kammer J, Harasymowycz P, et al. The Ahmed Versus Baerveldt study: one-year treatment outcomes. Ophthalmology. 2011;118:2180-9 pubmed publisher
    ..To report the 1-year treatment outcomes of the Ahmed Versus Baerveldt (AVB) Study...
  66. Wang S, Singh K, Lin S. The association between glaucoma prevalence and supplementation with the oxidants calcium and iron. Invest Ophthalmol Vis Sci. 2012;53:725-31 pubmed publisher
    To investigate the relationship between supplementary consumption of the oxidants calcium and iron and the prevalence of glaucoma.
  67. Leung C, Yu M, Weinreb R, Ye C, Liu S, Lai G, et al. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a prospective analysis of age-related loss. Ophthalmology. 2012;119:731-7 pubmed publisher
    ..To investigate age-related changes of the retinal nerve fiber layer (RNFL) imaged by a spectral-domain optical coherence tomography (OCT)...
  68. Junoy Montolio F, Wesselink C, Jansonius N. Persistence, spatial distribution and implications for progression detection of blind parts of the visual field in glaucoma: a clinical cohort study. PLoS ONE. 2012;7:e41211 pubmed publisher
    Visual field testing is an essential part of glaucoma care. It is hampered by variability related to the disease itself, response errors and fatigue...
  69. Chidlow G, Wood J, Ebneter A, Casson R. Interleukin-6 is an efficacious marker of axonal transport disruption during experimental glaucoma and stimulates neuritogenesis in cultured retinal ganglion cells. Neurobiol Dis. 2012;48:568-81 pubmed publisher
    ..that chronically activated glia contribute to the pathology of various neurodegenerative diseases, including glaucoma. One means by which this can occur is through the release of neurotoxic, proinflammatory factors...
  70. Kimura Y, Hangai M, Morooka S, Takayama K, Nakano N, Nukada M, et al. Retinal nerve fiber layer defects in highly myopic eyes with early glaucoma. Invest Ophthalmol Vis Sci. 2012;53:6472-8 pubmed
    ..To compare the retinal nerve fiber layer (RNFL) defects in early glaucomatous eyes between highly and non-highly myopic eyes...
  71. Pakravan M, Yazdani S, Javadi M, Amini H, Behroozi Z, Ziaei H, et al. A population-based survey of the prevalence and types of glaucoma in central Iran: the Yazd eye study. Ophthalmology. 2013;120:1977-84 pubmed publisher
    To describe the prevalence and types of glaucoma in Yazd, central Iran.
  72. Mansouri K, Medeiros F, Weinreb R. Global rates of glaucoma surgery. Graefes Arch Clin Exp Ophthalmol. 2013;251:2609-15 pubmed publisher
    To estimate global rates of glaucoma surgery.
  73. Natarajan J, Chattopadhyay S, Ang M, Darwitan A, Foo S, Zhen M, et al. Sustained release of an anti-glaucoma drug: demonstration of efficacy of a liposomal formulation in the rabbit eye. PLoS ONE. 2011;6:e24513 pubmed publisher
    Topical medication remains the first line treatment of glaucoma; however, sustained ocular drug delivery via topical administration is difficult to achieve...
  74. Salim S. Current variations of glaucoma filtration surgery. Curr Opin Ophthalmol. 2012;23:89-95 pubmed publisher
    Trabeculectomy continues to be the most effective incisional surgery for uncontrolled glaucoma. Since its introduction by Cairns in 1968, the procedure has undergone numerous modifications...
  75. Zhu Y, Zhang L, Schmidt J, Gidday J. Glaucoma-induced degeneration of retinal ganglion cells prevented by hypoxic preconditioning: a model of glaucoma tolerance. Mol Med. 2012;18:697-706 pubmed publisher
    ..after both 3 and 10 wks of sustained intraocular hypertension in an adult mouse model of inducible, open-angle glaucoma, with or without RHP before intraocular pressure elevation...
  76. Chaudhry M, Grover S, Baisakhiya S, Bajaj A, Bhatia M. Artificial drainage devices for glaucoma surgery: an overview. Nepal J Ophthalmol. 2012;4:295-302 pubmed publisher
    ..The ADDs, both valved and non-valved, are available for end stage or refractory glaucoma. Currently, some of these devices, particularly the Express shunt, are recommended for the primary treatment of ..
  77. Choudhari N, Neog A, Sharma A, Iyer G, Srinivasan B. Our experience of fibrin sealant-assisted implantation of Ahmed glaucoma valve. Indian J Ophthalmol. 2013;61:23-7 pubmed publisher
    To report our experience with the fibrin sealant as a suture substitute for securing the human scleral patch graft during implantation of Ahmed glaucoma valve (AGV).
  78. Huang W, Fan Q, Wang W, Zhou M, Laties A, Zhang X. Collagen: a potential factor involved in the pathogenesis of glaucoma. Med Sci Monit Basic Res. 2013;19:237-40 pubmed publisher
    Numerous studies have been completed on glaucoma pathogenesis. However, the potential and controversial interaction between ocular biomechanical properties and the glaucomatous diseases process has received much more attention recently...
  79. Lorber B, Guidi A, Fawcett J, Martin K. Activated retinal glia mediated axon regeneration in experimental glaucoma. Neurobiol Dis. 2012;45:243-52 pubmed publisher
    b>Glaucoma, a leading cause of blindness, is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons in the optic nerve and their cell bodies in the retina...
  80. Balaggan K, Ali R. Ocular gene delivery using lentiviral vectors. Gene Ther. 2012;19:145-53 pubmed publisher
  81. Meyer J, Lawrence S. What's new in laser treatment for glaucoma?. Curr Opin Ophthalmol. 2012;23:111-7 pubmed publisher
    This review highlights recently published studies on prevailing and newer laser therapies in glaucoma and critically evaluates their roles in the treatment algorithm.
  82. De Moraes C, Liebmann J, Ritch R, Hood D. Understanding disparities among diagnostic technologies in glaucoma. Arch Ophthalmol. 2012;130:833-40 pubmed publisher
    To investigate causes of disagreement among 3 glaucoma diagnostic techniques: standard automated achromatic perimetry (SAP), the multifocal visual evoked potential technique (mfVEP), and optical coherence tomography (OCT).
  83. Giaconi J, Yu F, Stone K, Pedula K, Ensrud K, Cauley J, et al. The association of consumption of fruits/vegetables with decreased risk of glaucoma among older African-American women in the study of osteoporotic fractures. Am J Ophthalmol. 2012;154:635-44 pubmed publisher
    To explore the association between consumption of fruits and vegetables and the presence of glaucoma in older African-American women.
  84. O Leary N, Chauhan B, Artes P. Visual field progression in glaucoma: estimating the overall significance of deterioration with permutation analyses of pointwise linear regression (PoPLR). Invest Ophthalmol Vis Sci. 2012;53:6776-84 pubmed publisher
    ..To establish a method for estimating the overall statistical significance of visual field deterioration from an individual patient's data, and to compare its performance to pointwise linear regression...
  85. Figus M, Lazzeri S, Fogagnolo P, Iester M, Martinelli P, Nardi M. Supraciliary shunt in refractory glaucoma. Br J Ophthalmol. 2011;95:1537-41 pubmed publisher
    This study aimed to evaluate the efficacy of Gold Micro Shunt (GMS) for suprachoroidal drainage in patients with refractory glaucoma.
  86. Fraenkl S, Muser J, Groell R, Reinhard G, Orgul S, Flammer J, et al. Plasma citrate levels as a potential biomarker for glaucoma. J Ocul Pharmacol Ther. 2011;27:577-80 pubmed publisher
    To determine the possibility of plasma citrate as a biomarker in patients with glaucoma.
  87. Park H, Kim J, Park C. Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model. Cell Death Dis. 2012;3:e290 pubmed publisher
    ..This study used chronic hypertensive glaucoma rat model to investigate whether the autophagy pathway has a role in the apoptosis of retinal ganglion cells (..
  88. Folio L, Wollstein G, Schuman J. Optical coherence tomography: future trends for imaging in glaucoma. Optom Vis Sci. 2012;89:E554-62 pubmed publisher
    ..In this review, we present several promising initiatives currently in development or early phase of assessment that we expect to have a future impact on optical coherence tomography...
  89. Somner J, Sii F, Bourne R, Cross V, Burr J, Shah P. Moving from PROMs to POEMs for glaucoma care: a qualitative scoping exercise. Invest Ophthalmol Vis Sci. 2012;53:5940-7 pubmed publisher
    ..Over 30 PROMs have been described for use in glaucoma research, but their role in routine care is undefined...
  90. Mastropasqua L, Agnifili L, Mastropasqua R, Fasanella V. Conjunctival modifications induced by medical and surgical therapies in patients with glaucoma. Curr Opin Pharmacol. 2013;13:56-64 pubmed publisher
    Lowering intra-ocular pressure, either medically or surgically, is the proven strategy to control glaucoma, though profound changes to the ocular surface and conjunctiva are caused...
  91. Reinholdt L, Howell G, Czechanski A, Macalinao D, MacNicoll K, Lin C, et al. Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases. PLoS ONE. 2012;7:e50081 pubmed publisher
    ..The inbred mouse strain DBA/2J is a recalcitrant strain that is used as a model of many human diseases, including glaucoma, deafness and schizophrenia...
  92. Rao H, Addepalli U, Chaudhary S, Kumbar T, Senthil S, Choudhari N, et al. Ability of different scanning protocols of spectral domain optical coherence tomography to diagnose preperimetric glaucoma. Invest Ophthalmol Vis Sci. 2013;54:7252-7 pubmed publisher
    To evaluate the ability of the optic nerve head (ONH), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) parameters of spectral domain optical coherence tomograph (SDOCT) in detecting preperimetric glaucoma.