corneal opacity

Summary

Summary: Disorder occurring in the central or peripheral area of the cornea. The usual degree of transparency becomes relatively opaque.

Top Publications

  1. Casteels I, Devriendt K. Unilateral Peters' anomaly in a patient with DiGeorge syndrome. J Pediatr Ophthalmol Strabismus. 2005;42:311-3 pubmed
    ..2, a finding not previously described. This anterior segment anomaly can be explained by a problem in neural crest development, as neural crest cells are known to play a role in the developmental defects of this disorder...
  2. Verstraelen S, Jacobs A, De Wever B, Vanparys P. Improvement of the Bovine Corneal Opacity and Permeability (BCOP) assay as an in vitro alternative to the Draize rabbit eye irritation test. Toxicol In Vitro. 2013;27:1298-311 pubmed publisher
    ..The Bovine Corneal Opacity and Permeability (BCOP) assay is generally accepted as a valid in vitro alternative method to the Draize eye ..
  3. Oshima Y, Shima C, Maeda N, Tano Y. Chandelier retroillumination-assisted torsional oscillation for cataract surgery in patients with severe corneal opacity. J Cataract Refract Surg. 2007;33:2018-22 pubmed
    ..After the chandelier fiber is removed at the end of surgery, the 25-gauge incision self-seals. This technique is safe and provides excellent visualization during cataract surgery in patients with severe corneal opacities...
  4. Singh V, Santhiago M, Barbosa F, Agrawal V, Singh N, Ambati B, et al. Effect of TGF? and PDGF-B blockade on corneal myofibroblast development in mice. Exp Eye Res. 2011;93:810-7 pubmed publisher
    ..This study provides in situ evidence that TGF? and PDGF-B have important roles in modulating myofibroblast generation in the mouse cornea after haze-associated injury...
  5. Kolle S, Kandárová H, Wareing B, van Ravenzwaay B, Landsiedel R. In-house validation of the EpiOcular(TM) eye irritation test and its combination with the bovine corneal opacity and permeability test for the assessment of ocular irritation. Altern Lab Anim. 2011;39:365-87 pubmed
    In 2009, the Bovine Corneal Opacity and Permeability (BCOP) test was accepted by the regulatory bodies for the identification of corrosive and severe ocular irritants (Global Harmonised System [GHS] Category 1)...
  6. Ciralsky J, Colby K. Congenital corneal opacities: a review with a focus on genetics. Semin Ophthalmol. 2007;22:241-6 pubmed
    ..This article will review the clinical presentations, treatments and genetics of Peters' anomaly, congenital hereditary endothelial dystrophy, congenital hereditary stromal dystrophy and posterior polymorphous dystrophy...
  7. Khan K, Al Maskari A, McKibbin M, Carr I, Booth A, Mohamed M, et al. Genetic heterogeneity for recessively inherited congenital cataract microcornea with corneal opacity. Invest Ophthalmol Vis Sci. 2011;52:4294-9 pubmed publisher
    To investigate whether three consanguineous families from the Punjab province of Pakistan, with affected members with recessively inherited congenital cataract microcornea with corneal opacity, are genetically homogeneous.
  8. Thornton I, Xu M, Krueger R. Comparison of standard (0.02%) and low dose (0.002%) mitomycin C in the prevention of corneal haze following surface ablation for myopia. J Refract Surg. 2008;24:S68-76 pubmed
    ..To retrospectively compare the safety and efficacy of lower dose mitomycin C (MMC) (0.002%) to that of the standard dose (0.02%) in eyes treated with photorefractive keratectomy (PRK) for myopia...
  9. Ginis H, Pentari I, De Brouwere D, Bouzoukis D, Naoumidi I, Pallikaris I. Narrow angle light scatter in rabbit corneas after excimer laser surface ablation. Ophthalmic Physiol Opt. 2009;29:357-62 pubmed publisher
    ..5 degrees full-width at half maximum (FWHM) in accordance with the sizes of the subepithelial structures (5-150 microm).The intensity of scattered light is correlated with the thickness of the subepithelial scar-tissue layer...

More Information

Publications65

  1. Woodward M, Randleman J, Larson P. In vivo confocal microscopy of polymorphic amyloid degeneration and posterior crocodile shagreen. Cornea. 2007;26:98-101 pubmed
    ..To report the in vivo confocal microscopic findings of combined polymorphic amyloid degeneration and posterior crocodile shagreen and correlate these findings with clinical presentations and previous histopathologic analysis...
  2. Durkin S, Casson R, Newland H, Aung T, Shein W, Muecke J, et al. Prevalence of trachoma-related trichiasis and corneal opacity in rural Myanmar: the Meiktila Eye Study. Ophthalmology. 2007;114:e7-11 pubmed
    To describe the prevalence of trachomatous trichiasis and corneal opacity (CO) within central Myanmar.
  3. Yin J, Huang Z, Wu B, Shi Y, Cao C, Lu Y. Lornoxicam protects mouse cornea from UVB-induced damage via inhibition of NF-{kappa}B activation. Br J Ophthalmol. 2008;92:562-8 pubmed publisher
    ..The COX inhibitors are protective against UVB-induced skin damage. The aim of this study is to determine the effect of lornoxicam, a potent COX inhibitor, on UVB-induced corneal damage and its mechanism in a mouse model...
  4. Sharma A, Mehan M, Sinha S, Cowden J, Mohan R. Trichostatin a inhibits corneal haze in vitro and in vivo. Invest Ophthalmol Vis Sci. 2009;50:2695-701 pubmed publisher
    ..The authors evaluated TSA cytotoxicity and its antifibrogenic activity on TGF-beta-driven fibrosis in the cornea with the use of in vitro and in vivo models...
  5. Gong N, Pleyer U, Ritter T, Knop E, Chen X. Corneal allograft endothelial cell replacement represents a reparative response to transplant injury. Mol Vis. 2009;15:654-61 pubmed
    ..To elucidate the injury of corneal allograft endothelial cells (ECs) upon rejection and the subsequent replacement process of the cells...
  6. Belliveau M, Brownstein S, Agapitos P, Font R. Ultrastructural features of posterior crocodile shagreen of the cornea. Surv Ophthalmol. 2009;54:569-75 pubmed publisher
    ..We believe that posterior crocodile shagreen is most likely a degenerative disorder and that it should be distinguished from central cloudy dystrophy of François by its non-familial pattern of occurrence...
  7. Hanna N, Eickholt K, Agamanolis D, Burnstine R, Edward D. Atypical Peters plus syndrome with new associations. J AAPOS. 2010;14:181-3 pubmed publisher
    ..In addition, autopsy findings suggested that severe developmental angle anomalies may be the cause of glaucoma in some of these patients...
  8. Jiang Y, Liu C, Wu L, Shao Y. [Fine mapping of mutant gene related corneal opacity mouse with SNPs]. Yi Chuan. 2010;32:486-91 pubmed
    To further investigate the genetic mechanism of the mutant mice(B6-Co) with hereditary corneal opacity phenotype obtained by ENU-induced mutagenesis from B6 in previous study, SNP markers were used to map the mutant gene of B6-Co mice...
  9. Mohan R, Tovey J, Gupta R, Sharma A, Tandon A. Decorin biology, expression, function and therapy in the cornea. Curr Mol Med. 2011;11:110-28 pubmed
    ..that mutations in the decorin gene are associated with congenital stromal dystrophy, a disease that leads to corneal opacity and visual abnormalities...
  10. Bhandari R, Ferri S, Whittaker B, Liu M, Lazzaro D. Peters anomaly: review of the literature. Cornea. 2011;30:939-44 pubmed publisher
    ..We performed a literature review of multiple case reports and case series to better define the common characteristics and unusual findings associated with Peters anomaly...
  11. Khan K, Rudkin A, Parry D, Burdon K, McKibbin M, Logan C, et al. Homozygous mutations in PXDN cause congenital cataract, corneal opacity, and developmental glaucoma. Am J Hum Genet. 2011;89:464-73 pubmed publisher
    ..PXDN) in two consanguineous Pakistani families with congenital cataract-microcornea with mild to moderate corneal opacity and in a consanguineous Cambodian family with developmental glaucoma and severe corneal opacification...
  12. Tomita M, Chiba A, Matsuda J, Nawa Y. Evaluation of LASIK treatment with the Femto LDV in patients with corneal opacity. J Refract Surg. 2012;28:25-30 pubmed publisher
    To evaluate the relative effectiveness and safety of LASIK using the Femto LDV (Ziemer Ophthalmic Systems AG) and IntraLase FS 60 (Abbott Medical Optics Inc) femtosecond lasers in patients with corneal opacity.
  13. Myrna K, Mendonsa R, Russell P, Pot S, Liliensiek S, Jester J, et al. Substratum topography modulates corneal fibroblast to myofibroblast transformation. Invest Ophthalmol Vis Sci. 2012;53:811-6 pubmed publisher
    ..The purpose of this study was to determine the effect of topographic cues on TGF?-induced myofibroblast transformation of corneal cells...
  14. Nagayasu A, Nakamura T, Yamato O, Tsuzuki K, Hosaka Y, Ueda H, et al. Morphological analysis of corneal opacity in Shiba dog with GM1 gangliosidosis. J Vet Med Sci. 2008;70:881-6 pubmed
    ..Shiba dogs affected with GM1 gangliosidosis have been found to suffer from corneal opacity. In our morphological analysis, keratocyte enlargement was induced by abnormal intracellular accumulation of ..
  15. Richter L, Flodman P, Barria von Bischhoffshausen F, Burch D, Brown S, Nguyen L, et al. Clinical variability of autosomal dominant cataract, microcornea and corneal opacity and novel mutation in the alpha A crystallin gene (CRYAA). Am J Med Genet A. 2008;146A:833-42 pubmed publisher
    ..a four-generation Chilean family (ADC54) including 13 affected individuals with cataracts, microcornea and/or corneal opacity. All individuals underwent a complete ophthalmologic exam...
  16. Vanathi M, Panda A, Vengayil S, Chaudhuri Z, Dada T. Pediatric keratoplasty. Surv Ophthalmol. 2009;54:245-71 pubmed publisher
    ..Successful penetrating keratoplasty in children requires careful preoperative evaluation and selection of patients follow-up by well-motivated parents, an expert corneal transplant surgeon, and a devoted pediatric ophthalmologist...
  17. Nischal K. Congenital corneal opacities - a surgical approach to nomenclature and classification. Eye (Lond). 2007;21:1326-37 pubmed
    ..It is time to only accept studies of CCO genotype/phenotype correlation for publication if there is clinical phenotype augmented by anterior segment imaging (OCT or high-frequency ultrasound) or histology or both...
  18. Jain K, Kumar S, Jain C, Malik V. Terrien's marginal degeneration: an unusual presentation in an indian female. Nepal J Ophthalmol. 2009;1:141-2 pubmed
    ..This case was unique in that, unlike routine presentation seen in this type of disorder, the gutter was located more anteriorly in the cornea and was not associated with any vascularization...
  19. Thornton I, Puri A, Xu M, Krueger R. Low-dose mitomycin C as a prophylaxis for corneal haze in myopic surface ablation. Am J Ophthalmol. 2007;144:673-681 pubmed
    ..To evaluate the efficacy of low-dose (0.002%) mitomycin C (MMC) vs no prophylactic MMC (control) in reducing corneal haze after surface laser ablation...
  20. Salomao M, Wilson S. Corneal molecular and cellular biology update for the refractive surgeon. J Refract Surg. 2009;25:459-66 pubmed
    ..To review clinically relevant progress in understanding cellular and molecular interactions in the cornea that relate to refractive surgical outcomes in patients...
  21. Edward D, Al Rajhi A, Lewis R, Curry S, Wang Z, Bejjani B. Molecular basis of Peters anomaly in Saudi Arabia. Ophthalmic Genet. 2004;25:257-70 pubmed
  22. Ozeki H, Shirai S, Nozaki M, Sakurai E, Mizuno S, Ashikari M, et al. Ocular and systemic features of Peters' anomaly. Graefes Arch Clin Exp Ophthalmol. 2000;238:833-9 pubmed
    ..To clarify the relationship between associated systemic anomalies and ocular manifestations in patients with Peters' anomaly, a retrospective study was conducted...
  23. Carones F, Vigo L, Scandola E, Vacchini L. Evaluation of the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy. J Cataract Refract Surg. 2002;28:2088-95 pubmed
  24. Plskova J, Kuffova L, Filipec M, Holan V, Forrester J. Quantitative evaluation of the corneal endothelium in the mouse after grafting. Br J Ophthalmol. 2004;88:1209-16 pubmed
    ..In this study the authors aimed to evaluate corneal endothelium in mice at different times after transplantation and to correlate endothelial integrity with corneal graft survival...
  25. Bhartiya P, Sharma N, Ray M, Sinha R, Vajpayee R. Trypan blue assisted phacoemulsification in corneal opacities. Br J Ophthalmol. 2002;86:857-9 pubmed
    ..To evaluate the efficacy of trypan blue for enhancing visualisation during phacoemulsification and foldable lens implantation in cases of cataract with corneal opacities...
  26. Ormestad M, Blixt A, Churchill A, Martinsson T, Enerback S, Carlsson P. Foxe3 haploinsufficiency in mice: a model for Peters' anomaly. Invest Ophthalmol Vis Sci. 2002;43:1350-7 pubmed
    ..To evaluate the importance in anterior segment dysgenesis of genetic variation in Foxe3, a gene encoding a forkhead transcription factor specifically expressed in the lens...
  27. Rezende R, Uchoa U, Uchoa R, Rapuano C, Laibson P, Cohen E. Congenital corneal opacities in a cornea referral practice. Cornea. 2004;23:565-70 pubmed
    ..To address the primary causes of the congenital corneal opacities seen on the Cornea Service at Wills Eye Hospital (Philadelphia, PA), the associated systemic anomalies and their management...
  28. Netto M, Mohan R, Sinha S, Sharma A, Gupta P, Wilson S. Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, cellular proliferation, haze, and long-term keratocyte density in rabbits. J Refract Surg. 2006;22:562-74 pubmed
    ..To determine the mechanism through which topical mitomycin C prevents and treats corneal haze after photorefractive keratectomy (PRK) and to examine the effects of dosage and duration of exposure...
  29. Yildirim N, Basmak H, Sahin A. Prosthetic contact lenses: adventure or miracle. Eye Contact Lens. 2006;32:102-3 pubmed
    ..To show that if fitted and handled properly, iris painted contact lenses can be good cosmetic prostheses for disfigured or blind eyes for which no evisceration or enucleation is indicated...
  30. Xu H, Liu S, Xia X, Huang P, Wang P, Wu X. Mitomycin C reduces haze formation in rabbits after excimer laser photorefractive keratectomy. J Refract Surg. 2001;17:342-9 pubmed
    ..To investigate the effects of mitomycin C on haze after photorefractive keratectomy (PRK)...
  31. Bredrup C, Knappskog P, Majewski J, Rødahl E, Boman H. Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene. Invest Ophthalmol Vis Sci. 2005;46:420-6 pubmed
    ..To describe the clinical and pathologic characteristics of a family with a congenital stromal dystrophy of the cornea and to identify the genetic basis for this disorder...
  32. Winkler von Mohrenfels C, Reischl U, Lohmann C. Corneal haze after photorefractive keratectomy for myopia: role of collagen IV mRNA typing as a predictor of haze. J Cataract Refract Surg. 2002;28:1446-51 pubmed
    ..To develop a test based on the individual expression of collagen type IV synthesis in corneal epithelial cells to identify patients who have the potential for significant corneal haze after myopic photorefractive keratectomy (PRK)...
  33. Nishimura A, Kobayashi A, Segawa Y, Sugiyama K. Endoillumination-assisted cataract surgery in a patient with corneal opacity. J Cataract Refract Surg. 2003;29:2277-80 pubmed
    We present a technique to better visualize cataracts through corneal opacity. A 70-year-old Japanese woman with retinal detachment, cataract, and corneal opacity in the left eye was treated with phacoemulsification, 3-port vitrectomy, ..
  34. Nischal K, Naor J, Jay V, MacKeen L, Rootman D. Clinicopathological correlation of congenital corneal opacification using ultrasound biomicroscopy. Br J Ophthalmol. 2002;86:62-9 pubmed
  35. Chakravarti S, Magnuson T, Lass J, Jepsen K, LaMantia C, Carroll H. Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican. J Cell Biol. 1998;141:1277-86 pubmed
    ..Most importantly, these results provide a definitive link between a necessity for lumican in the development of a highly organized collagenous matrix and corneal transparency...
  36. Al Torbak A. Outcome of combined Ahmed glaucoma valve implant and penetrating keratoplasty in refractory congenital glaucoma with corneal opacity. Cornea. 2004;23:554-9 pubmed
    To investigate surgical outcomes following simultaneous Ahmed glaucoma valve implant and penetrating keratoplasty (PKP) in the management of refractory congenital glaucoma with corneal opacity.
  37. West E, Munoz B, Imeru A, Alemayehu W, Melese M, West S. The association between epilation and corneal opacity among eyes with trachomatous trichiasis. Br J Ophthalmol. 2006;90:171-4 pubmed
    To examine the association between epilation and corneal opacity (CO) among trichiasis patients presenting for surgery.
  38. Stone D, Siatkowski R. Congenital retinal dystrophy and corneal opacity in trisomy 8 mosaicism. J AAPOS. 2005;9:290-1 pubmed
    ..A finding that has been described in several patients with trisomy 8 is a central corneal opacity, but there are no data regarding the natural history of this finding; the corneal opacity in our patient ..
  39. Shimmura S, Ohashi Y, Shiroma H, Shimazaki J, Tsubota K. Corneal opacity and cataract: triple procedure versus secondary approach. Cornea. 2003;22:234-8 pubmed
    ..To determine the efficacy of planned secondary cataract surgery after keratoplasty...
  40. Titiyal J, Das A, Dada V, Tandon R, Ray M, Vajpayee R. Visual performance of rigid gas permeable contact lenses in patients with corneal opacity. CLAO J. 2001;27:163-5 pubmed
    To evaluate the visual performance of rigid gas permeable (RGP) contact lenses in patients with nebular and nebulo-macular corneal opacity and correlate the improvement in visual acuity with other visual parameters.
  41. Burton M, Bowman R, Faal H, Aryee E, Ikumapayi U, Alexander N, et al. The long-term natural history of trachomatous trichiasis in the Gambia. Invest Ophthalmol Vis Sci. 2006;47:847-52 pubmed
    ..Trachoma is the leading infectious cause of blindness. However, there are few data on the natural history of trachomatous trichiasis to guide program planning or that investigate its pathogenesis...
  42. Memarzadeh F, Li Y, Francis B, Smith R, Gutmark J, Huang D. Optical coherence tomography of the anterior segment in secondary glaucoma with corneal opacity after penetrating keratoplasty. Br J Ophthalmol. 2007;91:189-92 pubmed
    ..To evaluate secondary glaucoma after penetrating keratoplasty with anterior-segment optical coherence tomography (OCT)...
  43. Plskova J, Kuffova L, Holan V, Filipec M, Forrester J. Evaluation of corneal graft rejection in a mouse model. Br J Ophthalmol. 2002;86:108-13 pubmed
    ..In this perspective, previous experimental studies of allograft rejection plus some new data are reviewed to support the latter mechanism...
  44. Paulger B, Kraus E, Pulitzer D, Moore C. Xp microdeletion syndrome characterized by pathognomonic linear skin defects on the head and neck. Pediatr Dermatol. 1997;14:26-30 pubmed
    ..We report the thirteenth case and review the clinical and cytogenetic aspects of this disorder. In addition we discuss new findings pertaining to the histopathology of the skin lesions...
  45. Vajpayee R, Sharma N, Dada T, Pushker N. Optical sector iridectomy in corneal opacities. Cornea. 1999;18:262-4 pubmed
    ..To evaluate the visual outcome after optical sector iridectomy in cases of corneal opacities...
  46. Chakravarti S, Petroll W, Hassell J, Jester J, Lass J, Paul J, et al. Corneal opacity in lumican-null mice: defects in collagen fibril structure and packing in the posterior stroma. Invest Ophthalmol Vis Sci. 2000;41:3365-73 pubmed
    ..The purpose of the present study was to analyze the loss of transparency quantitatively and to define the associated corneal collagen fibril and stromal defects...
  47. Hayashida Y, Nishida K, Yamato M, Yang J, Sugiyama H, Watanabe K, et al. Transplantation of tissue-engineered epithelial cell sheets after excimer laser photoablation reduces postoperative corneal haze. Invest Ophthalmol Vis Sci. 2006;47:552-7 pubmed
    ..To apply tissue-engineered cell sheet transplantation after excimer laser keratectomy as a novel approach for the reduction of postoperative corneal haze...
  48. Hanson I, Fletcher J, Jordan T, Brown A, Taylor D, Adams R, et al. Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly. Nat Genet. 1994;6:168-73 pubmed
    ..We therefore propose that a variety of anterior segment anomalies may be associated with PAX6 mutations...
  49. Møller Pedersen T. Keratocyte reflectivity and corneal haze. Exp Eye Res. 2004;78:553-60 pubmed
    ..A more comprehensive model to understand corneal transparency is needed and should include the interaction of visible light with the physical structure of the keratocyte and its subcellular constituents...
  50. Meek K, Leonard D, Connon C, Dennis S, Khan S. Transparency, swelling and scarring in the corneal stroma. Eye (Lond). 2003;17:927-36 pubmed
    ..This paper briefly reviews current explanations for corneal transparency and uses a well-developed model to try to explain the increased light scattering either accompanying corneal swelling or following phototherapeutic keratectomy (PTK)...
  51. Matsuda J, Hieda O, Kinoshita S. [Quantification of corneal opacity after refractive corneal surgery using the anterior segment analyzer]. Nippon Ganka Gakkai Zasshi. 2007;111:447-53 pubmed
    ..01), whereas no difference was observed between the 2 groups at 4 and 12 weeks after surgery. Pentacam is useful in quantifying corneal haze following excimer laser keratectomy. ..
  52. Chen S, Sun M, Meng X, Iozzo R, Kao W, Birk D. Pathophysiological mechanisms of autosomal dominant congenital stromal corneal dystrophy: C-terminal-truncated decorin results in abnormal matrix assembly and altered expression of small leucine-rich proteoglycans. Am J Pathol. 2011;179:2409-19 pubmed publisher
  53. Xiao X, Xie L. The influencing factors and characteristics of corneal graft endothelial decompensation after penetrating keratoplasty. Eur J Ophthalmol. 2010;20:21-8 pubmed
  54. Zaidman G, Flanagan J, Furey C. Long-term visual prognosis in children after corneal transplant surgery for Peters anomaly type I. Am J Ophthalmol. 2007;144:104-108 pubmed
    ..To evaluate the long-term visual prognosis in children with corneal transplant surgery for Peters anomaly type I...
  55. Nguyen D, Srinivasan S, Hiscott P, Kaye S. Thimerosal-induced limbal stem cell failure: report of a case and review of the literature. Eye Contact Lens. 2007;33:196-8 pubmed
    ..To report a case of unilateral total limbal stem cell (LSC) failure and corneal opacification secondary to thimerosal- and contact lens-induced ocular surface toxicity...
  56. Wirbelauer C. OCT of corneal opacities. Ophthalmology. 2008;115:589-90; author reply 590 pubmed publisher