corneal neovascularization

Summary

Summary: New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.

Top Publications

  1. Azar D. Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc. 2006;104:264-302 pubmed
    ..To determine the molecular basis of corneal avascularity during wound healing and determine the role of angiogenic and antiangiogenic factors in corneal vasculogenesis...
  2. Bock F, Onderka J, Dietrich T, Bachmann B, Kruse F, Paschke M, et al. Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis. Invest Ophthalmol Vis Sci. 2007;48:2545-52 pubmed
    ..S. Food and Drug Administration for the treatment of colon carcinomas. The mouse model of suture-induced corneal neovascularization was used to assess the antihemangiogenic and antilymphangiogenic effect of bevacizumab by systemic and ..
  3. Rogers M, Birsner A, D Amato R. The mouse cornea micropocket angiogenesis assay. Nat Protoc. 2007;2:2545-50 pubmed
    ..A skilled investigator can implant and grade 40 eyes in about 2.5 h. The results of the assay are used to assess the ability of potential therapeutic molecules or genetic differences to modulate angiogenesis in vivo...
  4. Bian F, Zhang M, Zhu Y. Inhibitory effect of curcumin on corneal neovascularization in vitro and in vivo. Ophthalmologica. 2008;222:178-86 pubmed publisher
    ..on the proliferation and the migration of human umbilical vein endothelial cells (HUVECs) and on the corneal neovascularization in the corneal alkaline burn rat model...
  5. Schwartz S, George J, Ben Shoshan J, Luboshits G, Avni I, Levkovitch Verbin H, et al. Drug modification of angiogenesis in a rat cornea model. Invest Ophthalmol Vis Sci. 2008;49:250-4 pubmed publisher
    ..The results indicate that the selection of drugs for treating different ophthalmic diseases should take into account their influence on angiogenic processes. ..
  6. Oh J, Kim M, Shin M, Lee H, Lee J, Wee W. The anti-inflammatory effect of subconjunctival bevacizumab on chemically burned rat corneas. Curr Eye Res. 2009;34:85-91 pubmed publisher
    ..To investigate the effect of bevacizumab in a model of corneal inflammation...
  7. Scorcia V, Busin M. Survival of mushroom keratoplasty performed in corneas with postinfectious vascularized scars. Am J Ophthalmol. 2012;153:44-50.e1 pubmed publisher
  8. Bahar I, Kaiserman I, McAllum P, Rootman D, Slomovic A. Subconjunctival bevacizumab injection for corneal neovascularization in recurrent pterygium. Curr Eye Res. 2008;33:23-8 pubmed publisher
    ..025%+/-0.19 (both not statistically different than zero, t-test). Short-term results suggest that subconjunctival bevacizumab is well tolerated but does not cause regression of corneal vessels in recurrent pterygium. ..
  9. Chen W, Lin C, Lin N, Tu I, Li J, Chow L, et al. Subconjunctival injection of bevacizumab (avastin) on corneal neovascularization in different rabbit models of corneal angiogenesis. Invest Ophthalmol Vis Sci. 2009;50:1659-65 pubmed publisher
    ..of this study was to evaluate the therapeutic effect of subconjunctival injection of bevacizumab on corneal neovascularization (NV) in different rabbit models...

More Information

Publications88

  1. Bock F, Onderka J, Dietrich T, Bachmann B, Pytowski B, Cursiefen C. Blockade of VEGFR3-signalling specifically inhibits lymphangiogenesis in inflammatory corneal neovascularisation. Graefes Arch Clin Exp Ophthalmol. 2008;246:115-9 pubmed
    ..This may open new treatment options to promote (corneal) graft survival without affecting hemangiogenesis. ..
  2. Hashemian M, Moghimi S, Kiumehr S, Riazi M, Amoli F. Prevention and treatment of corneal neovascularization: comparison of different doses of subconjunctival bevacizumab with corticosteroid in experimental rats. Ophthalmic Res. 2009;42:90-5 pubmed publisher
    ..of bevacizumab is efficacious in the prevention of formation as well as regression of major vessels compared to betamethasone in this rat model of corneal neovascularization. Even lower doses of bevacizumab might be efficacious.
  3. Saravia M, Zapata G, Ferraiolo P, Racca L, Berra A. Anti-VEGF monoclonal antibody-induced regression of corneal neovascularization and inflammation in a rabbit model of herpetic stromal keratitis. Graefes Arch Clin Exp Ophthalmol. 2009;247:1409-16 pubmed publisher
    ..To determine the efficacy of bevacizumab (Avastin), an anti-VEGF monoclonal antibody, administrated via subconjunctival injection as a corneal anti-angiogenic treatment...
  4. Lu P, Li L, Liu G, Zhang X, Mukaida N. Enhanced experimental corneal neovascularization along with aberrant angiogenic factor expression in the absence of IL-1 receptor antagonist. Invest Ophthalmol Vis Sci. 2009;50:4761-8 pubmed publisher
    To address the roles of the endogenously produced IL-1ra in the course of corneal neovascularization (CNV)...
  5. Williams K, Coster D. The immunobiology of corneal transplantation. Transplantation. 2007;84:806-13 pubmed
    ..Many corneal grafts in recipients with corneal neovascularization or the sequelae of ocular inflammation undergo irreversible rejection, despite topical immunosuppression ..
  6. Bock F, Onderka J, Hos D, Horn F, Martus P, Cursiefen C. Improved semiautomatic method for morphometry of angiogenesis and lymphangiogenesis in corneal flatmounts. Exp Eye Res. 2008;87:462-70 pubmed publisher
    ..Therefore the semiautomatic method can be used to detect even small effects on hem and lymphangiogenesis in murine corneal flatmounts with greater precision. ..
  7. Li N, Wang X, Wan P, Huang M, Wu Z, Liang X, et al. Tectonic lamellar keratoplasty with acellular corneal stroma in high-risk corneal transplantation. Mol Vis. 2011;17:1909-17 pubmed
    ..The areas of corneal neovascularization were 5.3±1.1 mm² and 45.2±4.9 mm² (p<0.05), respectively, after two weeks, and 25.1±4...
  8. Destafeno J, Kim T. Topical bevacizumab therapy for corneal neovascularization. Arch Ophthalmol. 2007;125:834-6 pubmed
  9. Oh E, Park K, Choi J, Joo C, Hahn S. Synthesis, characterization, and preliminary assessment of anti-Flt1 peptide-hyaluronate conjugate for the treatment of corneal neovascularization. Biomaterials. 2009;30:6026-34 pubmed publisher
    ..synthesize anti-Flt1 peptide-hyaluronate (HA) conjugate was successfully developed for the treatment of corneal neovascularization. Using tetrabutyl ammonium salt of HA (HA-TBA), water-insoluble anti-Flt1 peptide could be conjugated ..
  10. Keskin U, Totan Y, Karadag R, Erdurmus M, Aydin B. Inhibitory effects of SU5416, a selective vascular endothelial growth factor receptor tyrosine kinase inhibitor, on experimental corneal neovascularization. Ophthalmic Res. 2012;47:13-8 pubmed publisher
    ..The aim of this study was to evaluate the effect of SU5416 on corneal neovascularization. Corneas were cauterized with silver nitrate/potassium nitrate sticks in 20 eyes of 20 BALB/C mice...
  11. Hurmeric V, Mumcuoglu T, Erdurman C, Kurt B, Dagli O, Durukan A. Effect of subconjunctival bevacizumab (Avastin) on experimental corneal neovascularization in guinea pigs. Cornea. 2008;27:357-62 pubmed publisher
    To evaluate the effect of subconjunctival bevacizumab (Avastin) on experimental corneal neovascularization in guinea pigs. Forty eyes of 40 guinea pigs were chemically cauterized with 75% silver nitrate and 25% potassium nitrate sticks...
  12. Foroutan A, Fariba B, Pejman B, Mahmoud J, Khalil G, Arash E, et al. Perilimbal bevacizumab injection for interface neovascularization after deep anterior lamellar keratoplasty. Cornea. 2010;29:1268-72 pubmed publisher
    ..5 mg for each injection). Total corneal neovascularization, longest neovascular length, and degree of neovascular circumference were evaluated by digital slit lamp ..
  13. Awadein A. Subconjunctival bevacizumab for vascularized rejected corneal grafts. J Cataract Refract Surg. 2007;33:1991-3 pubmed
    We describe 3 patients who experienced corneal neovascularization following keratoplasty and were treated with a single subconjunctival injection of 2.5 mg bevacizumab...
  14. Lima e Silva R, Shen J, Hackett S, Kachi S, Akiyama H, Kiuchi K, et al. The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization. FASEB J. 2007;21:3219-30 pubmed
    ..They provide new targets for therapeutic intervention that may help to bolster and supplement effects obtained with VEGF antagonists. ..
  15. Gong Y, Koh D. Neutrophils promote inflammatory angiogenesis via release of preformed VEGF in an in vivo corneal model. Cell Tissue Res. 2010;339:437-48 pubmed publisher
    ..Intervention measures targeting neutrophils may therefore help to deal with abnormal angiogenesis involved in chronic inflammatory diseases. ..
  16. Muether P, Dell S, Kociok N, Zahn G, Stragies R, Vossmeyer D, et al. The role of integrin alpha5beta1 in the regulation of corneal neovascularization. Exp Eye Res. 2007;85:356-65 pubmed
    ..alpha(5)beta(1)-inhibiting small molecule is able to reduce angiogenesis in a model of inflammatory corneal neovascularization. Corneal neovascularization was induced in C57Bl/6 mice by NaOH-application and debridement of the ..
  17. Fletcher E, Chong N. Looking beyond Lucentis on the management of macular degeneration. Eye (Lond). 2008;22:742-50 pubmed publisher
    ..Oxidative stress, inflammation, hypoxia, and angiogenesis are key pathophysiological processes in AMD, this diversity has provided a variety of possible areas amenable to modification to enhance the treatment options for AMD. ..
  18. Symes R, Poole T. Corneal graft surgery combined with subconjunctival bevacizumab (avastin). Cornea. 2010;29:691-3 pubmed publisher
    ..To describe the use of subconjunctival bevacizumab (Avastin) as an adjunctive treatment in a vascularized cornea at the time of lamellar keratoplasty to reduce the risk of graft rejection...
  19. Mwaikambo B, Sennlaub F, Ong H, Chemtob S, Hardy P. Genetic ablation of CD36 induces age-related corneal neovascularization. Cornea. 2008;27:1037-41 pubmed publisher
    ..CD36-/- mice develop corneal NV that increases in severity with age, thus accentuating the role of CD36 in preserving corneal avascularity. ..
  20. Qazi Y, Stagg B, Singh N, Singh S, Zhang X, Luo L, et al. Nanoparticle-mediated delivery of shRNA.VEGF-a plasmids regresses corneal neovascularization. Invest Ophthalmol Vis Sci. 2012;53:2837-44 pubmed publisher
    ..shRNA) against VEGF-A-loaded poly(lactic co-glycolic acid) nanoparticles (PLGA NPs) in the sustained regression of murine corneal neovascularization.
  21. Turgut B, Guler M, Akpolat N, Demir T, Celiker U. The impact of tacrolimus on vascular endothelial growth factor in experimental corneal neovascularization. Curr Eye Res. 2011;36:34-40 pubmed publisher
    To investigate the impact of tacrolimus on vascular endothelial growth factor (VEGF) in experimental corneal neovascularization (NV) immunohistochemically.
  22. Chang J, Garg N, Lunde E, Han K, Jain S, Azar D. Corneal neovascularization: an anti-VEGF therapy review. Surv Ophthalmol. 2012;57:415-29 pubmed publisher
    b>Corneal neovascularization is a serious condition that can lead to a profound decline in vision. The abnormal vessels block light, cause corneal scarring, compromise visual acuity, and may lead to inflammation and edema...
  23. Qazi Y, Maddula S, Ambati B. Mediators of ocular angiogenesis. J Genet. 2009;88:495-515 pubmed
  24. Bock F, König Y, Dietrich T, Zimmermann P, Baier M, Cursiefen C. [Inhibition of angiogenesis in the anterior chamber of the eye]. Ophthalmologe. 2007;104:336-44 pubmed
    ..The aim of this article is to highlight some novel methods of local antiangiogenic treatment of the cornea and conjunctiva and in the anterior chamber of the eye...
  25. Jia C, Zhu W, Ren S, Xi H, Li S, Wang Y. Comparison of genome-wide gene expression in suture- and alkali burn-induced murine corneal neovascularization. Mol Vis. 2011;17:2386-99 pubmed
    Suture placement and alkali burn to the cornea are often used to induce inflammatory corneal neovascularization (CorNV) models in animals...
  26. Giménez F, Suryawanshi A, Rouse B. Pathogenesis of herpes stromal keratitis--a focus on corneal neovascularization. Prog Retin Eye Res. 2013;33:1-9 pubmed publisher
    ..We describe how VEGF and other angiogenic molecules are induced following infection and discuss the many ways by which CV can be controlled. Speculations are made regarding future approaches that could improve the management of HSK...
  27. Ahmed A, Berati H, Nalan A, Aylin S. Effect of bevacizumab on corneal neovascularization in experimental rabbit model. Clin Exp Ophthalmol. 2009;37:730-6 pubmed publisher
    To investigate the effect of bevacizumab in an experimental rabbit model of corneal neovascularization.
  28. Yoeruek E, Ziemssen F, Henke Fahle S, Tatar O, Tura A, Grisanti S, et al. Safety, penetration and efficacy of topically applied bevacizumab: evaluation of eyedrops in corneal neovascularization after chemical burn. Acta Ophthalmol. 2008;86:322-8 pubmed
    ..This pilot study was designed to evaluate experimental treatment with bevacizumab eyedrops in corneal neovascularization induced by alkali burn...
  29. Hayashi K, Hooper L, Detrick B, Hooks J. HSV immune complex (HSV-IgG: IC) and HSV-DNA elicit the production of angiogenic factor VEGF and MMP-9. Arch Virol. 2009;154:219-26 pubmed publisher
    ..These studies indicate that the continued presence of HSV-DNA and HSV-IC contribute to angiogenesis and inflammation in HSK. Thus, cytokines and TLRs may be potential targets for intervention...
  30. Kuo C, Yang L, Yang C, Lai C, Chen M, Chen C, et al. Inhibition of corneal neovascularization with plasmid pigment epithelium-derived factor (p-PEDF) delivered by synthetic amphiphile INTeraction-18 (SAINT-18) vector in an experimental model of rat corneal angiogenesis. Exp Eye Res. 2009;89:678-85 pubmed publisher
    ..carrying plasmid pigment epithelium-derived factor (p-PEDF) as an anti-angiogenesis strategy to treat corneal neovascularization in a rat model was evaluated. Four partially dried forms (Group A: 0 microg, B: 0...
  31. Onguchi T, Han K, Chang J, Azar D. Membrane type-1 matrix metalloproteinase potentiates basic fibroblast growth factor-induced corneal neovascularization. Am J Pathol. 2009;174:1564-71 pubmed publisher
    b>Corneal neovascularization is one of the leading causes of blindness...
  32. Al Mahmood S, Colin S, Farhat N, Thorin E, Steverlynck C, Chemtob S. Potent in vivo antiangiogenic effects of GS-101 (5'-TATCCGGAGGGCTCGCCATGCTGCT-3'), an antisense oligonucleotide preventing the expression of insulin receptor substrate-1. J Pharmacol Exp Ther. 2009;329:496-504 pubmed publisher
    ..In conclusion, these results suggest that IRS-1 is important for angiogenesis and that GS-101 could become a novel therapeutic tool against corneal angiogenesis...
  33. Usui T, Yamagami S, Kishimoto S, Seiich Y, Nakayama T, Amano S. Role of macrophage migration inhibitory factor in corneal neovascularization. Invest Ophthalmol Vis Sci. 2007;48:3545-50 pubmed
    To determine the role of macrophage migration inhibitory factor (MIF) in inflammatory corneal neovascularization.
  34. Xiao O, Xie Z, Lin B, Yin X, Pi R, Zhou S. Minocycline inhibits alkali burn-induced corneal neovascularization in mice. PLoS ONE. 2012;7:e41858 pubmed publisher
    The purpose of this study was to investigate the effects of minocycline on alkali burn-induced corneal neovascularization (CNV)...
  35. Bargagna Mohan P, Hamza A, Kim Y, Khuan Abby Ho Y, Mor Vaknin N, Wendschlag N, et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol. 2007;14:623-34 pubmed
    ..Finally, we show that WFA-induced inhibition of capillary growth in a mouse model of corneal neovascularization is compromised in vimentin-deficient mice...
  36. Yang L, Wang Y, Zhou Q, Chen P, Wang Y, Wang Y, et al. Inhibitory effects of polysaccharide extract from Spirulina platensis on corneal neovascularization. Mol Vis. 2009;15:1951-61 pubmed
    To assess the effects of polysaccharide extract from Spirulina platensis (PSP) on corneal neovascularization (CNV) in vivo and in vitro.
  37. Seta F, Patil K, Bellner L, Mezentsev A, Kemp R, Dunn M, et al. Inhibition of VEGF expression and corneal neovascularization by siRNA targeting cytochrome P450 4B1. Prostaglandins Other Lipid Mediat. 2007;84:116-27 pubmed publisher
    ..the link between CYP4B1 expression, 12-HETrE production and angiogenesis in a model of suture-induced corneal neovascularization. Intrastromal sutures induced a time-dependent neovascular response which was significantly attenuated ..
  38. Hashemian M, Z Mehrjardi H, Moghimi S, Tahvildari M, Mojazi Amiri H. Prevention of corneal neovascularization: comparison of different doses of subconjunctival bevacizumab with its topical form in experimental rats. Ophthalmic Res. 2011;46:50-4 pubmed publisher
    To compare the effect of different dosages of subconjunctival bevacizumab with its topical administration on preventing the development of corneal neovascularization (CNV) in a rat model of corneal chemical injury.
  39. Koenig Y, Bock F, Horn F, Kruse F, Straub K, Cursiefen C. Short- and long-term safety profile and efficacy of topical bevacizumab (Avastin) eye drops against corneal neovascularization. Graefes Arch Clin Exp Ophthalmol. 2009;247:1375-82 pubmed publisher
    To evaluate the short- and long-term in vivo safety and efficacy of topical bevacizumab (Avastin) application for treatment of corneal neovascularization secondary to a variety of corneal diseases.
  40. Ju M, Mailhos C, Bradley J, Dowie T, Ganley M, Cook G, et al. Simultaneous but not prior inhibition of VEGF165 enhances the efficacy of photodynamic therapy in multiple models of ocular neovascularization. Invest Ophthalmol Vis Sci. 2008;49:662-70 pubmed publisher
    ..To investigate the effect of the combined treatment of photodynamic therapy and specific VEGF165 inhibition with pegaptanib sodium (Macugen; Eyetech Pharmaceuticals, Lexington, MA) on ocular neovascularization...
  41. Mackenzie S, Tucker W, Poole T. Bevacizumab (avastin) for corneal neovascularization--corneal light shield soaked application. Cornea. 2009;28:246-7 pubmed publisher
    To describe a case where topical bevacizumab (Avastin) was used in an attempt to reduce corneal neovascularization before corneal graft.
  42. Sener E, Yuksel N, Yildiz D, Yilmaz B, Ozdemir O, Caglar Y, et al. The impact of subconjuctivally injected EGF and VEGF inhibitors on experimental corneal neovascularization in rat model. Curr Eye Res. 2011;36:1005-13 pubmed publisher
    ..the inhibitory effect of subconjunctival application of VEGF antibodies bevacizumab, ranibizumab, pegaptanib, and HER2 antibody trastuzumab on corneal neovascularization in a rat model of experimental corneal neovascularization.
  43. Ellenberg D, Azar D, Hallak J, Tobaigy F, Han K, Jain S, et al. Novel aspects of corneal angiogenic and lymphangiogenic privilege. Prog Retin Eye Res. 2010;29:208-48 pubmed publisher
    ..We also summarize pertinent published reports regarding corneal neovascularization (NV), corneal lymphangiogenesis and corneal angiogenic/lymphangiogenic privilege...
  44. Carrasco M. Subconjunctival bevacizumab for corneal neovascularization in herpetic stromal keratitis. Cornea. 2008;27:743-5 pubmed publisher
    To report an 81-year-old woman with corneal neovascularization secondary to herpetic stromal keratitis treated with subconjunctival bevacizumab and to discuss the role of this novel antiangiogenic treatment.
  45. Bachmann B, Bock F, Wiegand S, Maruyama K, Dana M, Kruse F, et al. Promotion of graft survival by vascular endothelial growth factor a neutralization after high-risk corneal transplantation. Arch Ophthalmol. 2008;126:71-7 pubmed publisher
  46. Al Abdullah A, Al Assiri A. Resolution of bilateral corneal neovascularization and lipid keratopathy after photodynamic therapy with verteporfin. Optometry. 2011;82:212-4 pubmed publisher
    The aim of this study was to describe the result of photodynamic therapy with verteporfin (Visudyne(®), Novartis Ophthalmics AG, Hettingen, Switzerland) on bilateral corneal neovascularization (CN) and lipid keratopathy.
  47. Lee H, Chung S. The effect of subconjunctival suramin on corneal neovascularization in rabbits. Cornea. 2010;29:86-92 pubmed publisher
    To evaluate the effect of subconjunctival injection of suramin on corneal neovascularization in rabbits.
  48. Sharma A, Bettis D, Cowden J, Mohan R. Localization of angiotensin converting enzyme in rabbit cornea and its role in controlling corneal angiogenesis in vivo. Mol Vis. 2010;16:720-8 pubmed
    ..caused corneal angiogenesis in the eyes of vehicle-treated control rabbits, and the mean area of corneal neovascularization was 1.8, 2.8, and 3.2 mm(2) on days 4, 9, and 14, respectively...
  49. Sanchez Huerta V, Gutierrez Sanchez L, Flores Estrada J. (-)-Epigallocatechin 3-gallate (EGCG) at the ocular surface inhibits corneal neovascularization. Med Hypotheses. 2011;76:311-3 pubmed publisher
    b>Corneal neovascularization is often accompanied by inflammatory response and loss of their immune privilege which leads to significant visual impairment and worsens the prognosis of a subsequent penetrating keratoplasty...
  50. You I, Im S, Lee S, Yoon K. Photodynamic therapy with verteporfin combined with subconjunctival injection of bevacizumab for corneal neovascularization. Cornea. 2011;30:30-3 pubmed publisher
    To investigate the efficacy of combined photodynamic therapy with verteporfin and subconjunctival injection of bevacizumab for the treatment of patients with corneal neovascularization.
  51. Saxena S, Kishore P, Pandey S, Khattri M, Kumar D. Topical bevacizumab for corneal neovascularization after penetrating keratoplasty. Eur J Ophthalmol. 2009;19:870-2 pubmed
    To evaluate the efficacy of topical bevacizumab for corneal neovascularization in graft rejection.
  52. Han Y, Lee J, Jung J, Lee J. Inhibitory effects of bevacizumab on angiogenesis and corneal neovascularization. Graefes Arch Clin Exp Ophthalmol. 2009;247:541-8 pubmed publisher
    To evaluate the inhibitory effects of bevacizumab (Avastin) on angiogenesis using cultured human umbilical vein endothelial cells (HUVECs) in vitro and on corneal neovascularization by subconjunctival injection of bevacizumab in vivo.
  53. Lu P, Li L, Wu Y, Mukaida N, Zhang X. Essential contribution of CCL3 to alkali-induced corneal neovascularization by regulating vascular endothelial growth factor production by macrophages. Mol Vis. 2008;14:1614-22 pubmed
    To evaluate the roles of CCL3 and its specific chemokine receptors, CCR1 and CCR5, in alkali-induced corneal neovascularization (CNV).
  54. Kim S, Ha B, Kim E, Tchah H, Kim T. The effect of topical bevacizumab on corneal neovascularization. Ophthalmology. 2008;115:e33-8 pubmed publisher
    To examine the effect of topical bevacizumab on corneal neovascularization (NV) over a period of 3 months.
  55. Kim T, Kim S, Kim S, Kim T, Kim E. Inhibition of experimental corneal neovascularization by using subconjunctival injection of bevacizumab (Avastin). Cornea. 2008;27:349-52 pubmed publisher
    To evaluate the effect of subconjunctival bevacizumab (Avastin) administration on corneal neovascularization (NV) in rabbits.
  56. Sugisaki K, Usui T, Nishiyama N, Jang W, Yanagi Y, Yamagami S, et al. Photodynamic therapy for corneal neovascularization using polymeric micelles encapsulating dendrimer porphyrins. Invest Ophthalmol Vis Sci. 2008;49:894-9 pubmed publisher
    ..of new photosensitizers (PSs), dendrimer porphyrin (DP, free DP), and DP encapsulation into polymeric micelles (DP-micelle) and the efficacy of photodynamic therapy (PDT) in an experimental corneal neovascularization model in mice.
  57. Mochimaru H, Usui T, Yaguchi T, Nagahama Y, Hasegawa G, Usui Y, et al. Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2. Invest Ophthalmol Vis Sci. 2008;49:2172-7 pubmed publisher
    To investigate whether the induction of cytotoxic T lymphocytes (CTLs) targeting VEGF receptor 2 inhibits corneal neovascularization caused by alkali injury.
  58. Dai C, Liu G, Li L, Xiao Y, Zhang X, Lu P. ADP-ribosylation factor as a novel target for corneal neovascularization regression. Mol Vis. 2012;18:2947-53 pubmed
    To evaluate the roles of ADP-ribosylation factor (ARF) in alkali-induced corneal neovascularization (CNV).
  59. Sun Y, Su L, Wang Z, Xu Y, Xu X. H-RN, a peptide derived from hepatocyte growth factor, inhibits corneal neovascularization by inducing endothelial apoptosis and arresting the cell cycle. BMC Cell Biol. 2013;14:8 pubmed publisher
    ..peptide H-RN, derived from the hepatocyte growth factor kringle 1 domain (HGF K1), in a mouse model of corneal neovascularization. The anti-angiogenic effect of H-RN on vascular endothelial growth factor (VEGF)-stimulated cell ..
  60. Lu P, Li L, Liu G, Van Rooijen N, Mukaida N, Zhang X. Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization. Cornea. 2009;28:562-9 pubmed publisher
    The purpose of this study was to investigate the role of infiltrating macrophages in the development of experimental corneal neovascularization.
  61. Lai L, Xiao X, Wu J. Inhibition of corneal neovascularization with endostatin delivered by adeno-associated viral (AAV) vector in a mouse corneal injury model. J Biomed Sci. 2007;14:313-22 pubmed
    ..adeno-associated viral (rAAV) vector carrying endostatin gene as an anti-angiogenesis strategy to treat corneal neovascularization in a mouse model was evaluated...
  62. Erdurmus M, Totan Y. Subconjunctival bevacizumab for corneal neovascularization. Graefes Arch Clin Exp Ophthalmol. 2007;245:1577-9 pubmed
    To report the efficacy of subconjunctival bevacizumab injection in patients with corneal neovascularization (NV).
  63. Fan X, Li J, Fu Y, Jia R, Lu W. [Small interference RNA targeting vascular endothelial growth factor inhibits rat corneal neovascularization]. Zhonghua Yan Ke Za Zhi. 2009;45:746-51 pubmed
    To test the effects of VEGF-siRNA-transfected corneal epithelium on corneal neovascularization (CNV).
  64. Peebo B, Fagerholm P, Traneus Röckert C, Lagali N. Cellular-level characterization of lymph vessels in live, unlabeled corneas by in vivo confocal microscopy. Invest Ophthalmol Vis Sci. 2010;51:830-5 pubmed publisher
    ..To determine whether in vivo confocal microscopy (IVCM) of the cornea can be used for the label-free detection and monitoring of lymph vessels in live corneas...
  65. Qian C, Bahar I, Levinger E, Rootman D. Combined use of superficial keratectomy and subconjunctival bevacizumab injection for corneal neovascularization. Cornea. 2008;27:1090-2 pubmed publisher
    To report the effect of superficial keratectomy combined with subconjunctival bevacizumab injection in 2 cases of corneal neovascularization (NV).
  66. Usui T, Sugisaki K, Iriyama A, Yokoo S, Yamagami S, Nagai N, et al. Inhibition of corneal neovascularization by blocking the angiotensin II type 1 receptor. Invest Ophthalmol Vis Sci. 2008;49:4370-6 pubmed publisher
    To determine the role of angiotensin II type 1 receptor (AT1R) signaling in corneal neovascularization.
  67. Lopez E, Rizzo M, Croxatto J, Mazzolini G, Gallo J. Suramab, a novel antiangiogenic agent, reduces tumor growth and corneal neovascularization. Cancer Chemother Pharmacol. 2011;67:723-8 pubmed publisher
    ..Our purpose was to evaluate the synergistic effect of two drugs, jointly administered as a pharmaceutical compound, in two animal models...
  68. Regenfuss B, Bock F, Parthasarathy A, Cursiefen C. Corneal (lymph)angiogenesis--from bedside to bench and back: a tribute to Judah Folkman. Lymphat Res Biol. 2008;6:191-201 pubmed publisher
  69. Barros L, Belfort R. The effects of the subconjunctival injection of bevacizumab (Avastin) on angiogenesis in the rat cornea. An Acad Bras Cienc. 2007;79:389-94 pubmed
    ..These results suggest that subconjunctival injection of bevacizumab is able to inhibit corneal angiogenesis independently of the day of treatment...
  70. Sivak J, Ostriker A, Woolfenden A, Demirs J, Cepeda R, Long D, et al. Pharmacologic uncoupling of angiogenesis and inflammation during initiation of pathological corneal neovascularization. J Biol Chem. 2011;286:44965-75 pubmed publisher
    ..We present data from an epithelial debridement model of corneal neovascularization describing an initial 3-day period when a substantial component of neovascular growth occurs...
  71. Mello G, Pizzolatti M, Wasilewski D, Santhiago M, Budel V, Moreira H. The effect of subconjunctival bevacizumab on corneal neovascularization, inflammation and re-epithelization in a rabbit model. Clinics (Sao Paulo). 2011;66:1443-50 pubmed
    To evaluate the use of subconjunctival bevacizumab on corneal neovascularization in an experimental rabbit model for its effect on vessel extension, inflammation, and corneal epithelialization.
  72. Zuo L, Fan Y, Wang F, Gu Q, Xu X. A siRNA targeting vascular endothelial growth factor-A inhibiting experimental corneal neovascularization. Curr Eye Res. 2010;35:375-84 pubmed publisher
    This study was designed to investigate whether synthetic small interference RNA (siRNA) targeting VEGF-A could inhibit mouse corneal neovascularization or not.
  73. Zhou S, Xie Z, Xiao O, Yang X, Heng B, Sato Y. Inhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1. Mol Vis. 2010;16:1389-98 pubmed
    ..To evaluate the activity of recombinant adenovirus encoding human vasohibin-1 (Ad-Vasohibin-1) on mouse corneal neovasularization induced by alkali burn...
  74. Chu H, Hu F, Yang C, Yeh P, Chen Y, Hou Y, et al. Subconjunctival injection of bevacizumab in the treatment of corneal neovascularization associated with lipid deposition. Cornea. 2011;30:60-6 pubmed publisher
    To determine the effects on corneal neovascularization (NV) and lipid deposition after subconjunctival injection of bevacizumab in patients who had NV associated with lipid keratopathy.
  75. Lim P, Fuchsluger T, Jurkunas U. Limbal stem cell deficiency and corneal neovascularization. Semin Ophthalmol. 2009;24:139-48 pubmed publisher
    ..One key feature of limbal stem cell deficiency is corneal neovascularization. There is a delicate balance between pro-angiogenic and anti-angiogenic factors that, in a normal cornea,..
  76. Kaplan N, Fatima A, Peng H, Bryar P, Lavker R, Getsios S. EphA2/Ephrin-A1 signaling complexes restrict corneal epithelial cell migration. Invest Ophthalmol Vis Sci. 2012;53:936-45 pubmed publisher
    ..Eph/ephrin signaling proteins are present in the corneal epithelium, where their function remains unknown. The authors examined the role of the EphA2 receptor and ephrin-A1 ligand in human corneal epithelial cell migration...
  77. Mansour A. Treatment of inflamed pterygia or residual pterygial bed. Br J Ophthalmol. 2009;93:864-5 pubmed publisher
    ..To describe the use of subconjunctival bevacizumab or ranibizumab, an approved antivascular endothelial growth factor for wet macular degeneration, in halting the inflammation of a pterygium or a partially excised pterygium...
  78. Avisar I, Weinberger D, Kremer I. Effect of subconjunctival and intraocular bevacizumab injections on corneal neovascularization in a mouse model. Curr Eye Res. 2010;35:108-15 pubmed publisher
    This study sought to evaluate the efficacy of bevacizumab (Avastin), an anti-VEGF agent, in the reduction of corneal neovascularization in a rodent model, and compare between the effect of intraocular and subconjunctival injection.
  79. Yoon K, You I, Kang I, Im S, Ahn J, Park Y, et al. Photodynamic therapy with verteporfin for corneal neovascularization. Am J Ophthalmol. 2007;144:390-395 pubmed
    To investigate the efficacy of photodynamic therapy with verteporfin for the treatment of patients with corneal neovascularization.