corneal injuries


Summary: Damage or trauma inflicted to the CORNEA by external means.

Top Publications

  1. Cucchiara R, Black S. Corneal abrasion during anesthesia and surgery. Anesthesiology. 1988;69:978-9 pubmed
  2. Wakai A, Lawrenson J, Lawrenson A, Wang Y, Brown M, Quirke M, et al. Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions. Cochrane Database Syst Rev. 2017;5:CD009781 pubmed publisher
    ..None of the trials addressed our primary outcome measure of participant-reported pain intensity reduction of 30% or more or 50% or more at 24 hours. ..
  3. Jiang Z, Liu G, Meng F, Wang W, Hao P, Xiang Y, et al. Paracrine effects of mesenchymal stem cells on the activation of keratocytes. Br J Ophthalmol. 2017;101:1583-1590 pubmed publisher
    ..MSC secretes certain factors that accelerate corneal re-epithelialisation. The paracrine effects of MSC on corneal wound healing including improvements in cell viability, migration and ECM formation. ..
  4. Wolf M, Maltseva I, Clay S, Pan P, Gajjala A, Chan M. Effects of MMP12 on cell motility and inflammation during corneal epithelial repair. Exp Eye Res. 2017;160:11-20 pubmed publisher
    ..These data support a role of MMP12 in promoting early repair processes following corneal epithelial injury by enhancing epithelial cell migration and neutrophil infiltration. ..
  5. Paschalis E, Zhou C, Lei F, Scott N, Kapoulea V, Robert M, et al. Mechanisms of Retinal Damage after Ocular Alkali Burns. Am J Pathol. 2017;187:1327-1342 pubmed publisher
    ..Intraocular pressure elevation was not observed in experimental alkali burns. These findings illuminate the mechanism by which alkali burns cause retinal damage and may have importance in designing therapies for retinal protection. ..
  6. Lin K, Loi M, Lien G, Cheng C, Pao H, Chang Y, et al. Topical administration of orbital fat-derived stem cells promotes corneal tissue regeneration. Stem Cell Res Ther. 2013;4:72 pubmed publisher
    ..Inhibition of corneal inflammation is related to corneal transparency. ..
  7. Murakami J, Nishida T, Otori T. Coordinated appearance of beta 1 integrins and fibronectin during corneal wound healing. J Lab Clin Med. 1992;120:86-93 pubmed
    ..Appearance and disappearance of beta 1 integrins and fibronectin are thus well coordinated during corneal epithelial wound healing process, suggesting an active involvement of beta 1 integrins and fibronectin. ..
  8. Gualtieri W, Cauchi D, Agius M. Traumatic aniridia in spared-lens open-globe rupture eye trauma. Graefes Arch Clin Exp Ophthalmol. 2011;249:1783-4 pubmed publisher
  9. Hamill C, Bozorg S, Peggy Chang H, Lee H, Sayegh R, Shukla A, et al. Corneal alkali burns: a review of the literature and proposed protocol for evaluation and treatment. Int Ophthalmol Clin. 2013;53:185-94 pubmed publisher

More Information


  1. Logothetis H, Leikin S, Patrianakos T. Management of anterior segment trauma. Dis Mon. 2014;60:247-53 pubmed publisher
  2. Bhogal M, Lwin C, Seah X, Peh G, Mehta J. Allogeneic Descemet's Membrane Transplantation Enhances Corneal Endothelial Monolayer Formation and Restores Functional Integrity Following Descemet's Stripping. Invest Ophthalmol Vis Sci. 2017;58:4249-4260 pubmed publisher
    ..7%, (P < 0.01). The presence of DM promoted endothelial wound healing, proliferation, and maintenance of a normal phenotype. DM transplantation recovered the abnormal peel phenotype back to that observed after endothelial scraping. ..
  3. Asahara T, Takahashi T, Masuda H, Kalka C, Chen D, Iwaguro H, et al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J. 1999;18:3964-72 pubmed
    ..These findings thus establish a novel role for VEGF in postnatal neovascularization which complements its known impact on angiogenesis. ..
  4. Marino G, Santhiago M, Santhanam A, Lassance L, Thangavadivel S, Medeiros C, et al. Epithelial basement membrane injury and regeneration modulates corneal fibrosis after pseudomonas corneal ulcers in rabbits. Exp Eye Res. 2017;161:101-105 pubmed publisher
    ..The endothelium and Descemet's membrane may serve a similar function modulating TGF? penetration into the posterior stroma-with the source of TGF? likely being the aqueous humor. ..
  5. Shah D, Ali M, Shukla D, Jain S, Aakalu V. Effects of histatin-1 peptide on human corneal epithelial cells. PLoS ONE. 2017;12:e0178030 pubmed publisher
    ..Histatin -1 peptide may enhance migration of HCLE cells and wound healing in vitro. These peptides may have benefit in corneal epithelial wounds and need to be investigated further. ..
  6. He J, Pham T, Kakazu A, Bazan H. Recovery of Corneal Sensitivity and Increase in Nerve Density and Wound Healing in Diabetic Mice After PEDF Plus DHA Treatment. Diabetes. 2017;66:2511-2520 pubmed publisher
    ..These results suggest that topical treatment with PEDF+DHA promotes corneal nerve regeneration and wound healing in diabetic mice and could potentially be exploited as a therapeutic option for the treatment of diabetic keratopathy. ..
  7. Swamynathan S, Loughner C, Swamynathan S. Inhibition of HUVEC tube formation via suppression of NFκB suggests an anti-angiogenic role for SLURP1 in the transparent cornea. Exp Eye Res. 2017;164:118-128 pubmed publisher
    ..Together, these results demonstrate that SLURP1 suppresses HUVEC tube formation by blocking nuclear translocation of NFκB, and suggest a potential role for SLURP1 in promoting corneal angiogenic privilege. ..
  8. Pal Ghosh S, Tadvalkar G, Stepp M. Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. Invest Ophthalmol Vis Sci. 2017;58:4959-4975 pubmed publisher
    ..These data provide insight into the mechanisms used by sensory nerves to reinnervate after injury. ..
  9. Zhang Z, Zhou M, Liu K, Zhu B, Liu H, Sun X, et al. Development of a new valid and reliable microsurgical skill assessment scale for ophthalmology residents. BMC Ophthalmol. 2018;18:68 pubmed publisher
    ..Hopefully, this tool will provide a structured template for other residency programs to assess their residents for basic microsurgical skills. ..
  10. Gallego Muñoz P, Ibares Frías L, Lorenzo E, Marcos S, Peréz Merino P, Bekesi N, et al. Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study. Invest Ophthalmol Vis Sci. 2017;58:3471-3480 pubmed publisher
  11. Kim J, Lim C, Kim B. Effects of nicotine on corneal wound healing following acute alkali burn. PLoS ONE. 2017;12:e0179982 pubmed publisher
    ..In conclusion, chronic administration of nicotine accelerated the angiogenic and fibrogenic healing processes in alkali-burned corneal tissue. ..
  12. Kanie S, Fujieda M, Hitotsumachi T, Suzuki S, Morita F, Hakoi K, et al. Alleviating effects of artificial tear instillation on S-1-induced ocular toxicity in dogs. J Toxicol Sci. 2017;42:291-300 pubmed publisher
    ..In conclusion, we demonstrated that artificial tear instillation can alleviate corneal surface damage induced by S-1 in dogs. ..
  13. Liu J, Xiao C, Wang H, Xue Y, Dong D, Lin C, et al. Local Group 2 Innate Lymphoid Cells Promote Corneal Regeneration after Epithelial Abrasion. Am J Pathol. 2017;187:1313-1326 pubmed publisher
    b>Corneal injuries and infections are the leading cause of blindness worldwide. Thus, understanding the mechanisms that control healing of the damaged cornea is critical for the development of new therapies to promptly restore vision...
  14. Mahendradas P, Vijayan P, Avadhani K, Garudadri S, Shetty B. Usefulness of anterior segment optical coherence tomography in the demonstration of intralenticular foreign body in traumatic cataract. Can J Ophthalmol. 2010;45:413-4 pubmed publisher
  15. Wilson S, Esposito A. Focus on molecules: interleukin-1: a master regulator of the corneal response to injury. Exp Eye Res. 2009;89:124-5 pubmed publisher