crataegus

Summary

Summary: A genus in the family ROSACEAE of shrubs and small trees native to the North Temperate Zone. It is best known for a traditional medication for the heart.

Top Publications

  1. Koller M, Lorenz W, Aubke W, Jensen A, Gerlach F, Kuhl J, et al. [Crataegus special extract WS 1442 in the treatment of early stages of CHD-associated heart failure]. MMW Fortschr Med. 2006;148:42 pubmed
  2. Belz G, Butzer R, Gaus W, Loew D. Camphor-Crataegus berry extract combination dose-dependently reduces tilt induced fall in blood pressure in orthostatic hypotension. Phytomedicine. 2002;9:581-8 pubmed
    In order to test the efficacy of a combination of natural D-camphor and an extract of fresh crataegus berries (Korodin Herz-Kreislauf-Tropfen) on orthostatic hypotension, two similar, controlled, randomized studies were carried out in a ..
  3. Jayalakshmi R, Niranjali Devaraj S. Cardioprotective effect of tincture of Crataegus on isoproterenol-induced myocardial infarction in rats. J Pharm Pharmacol. 2004;56:921-6 pubmed
    Tincture of Crataegus (TCR), an alcoholic extract of the berries of hawthorn (Crataegus oxycantha), is used in herbal and homeopathic medicine...
  4. Cheng S, Qiu F, Huang J, He J. Simultaneous determination of vitexin-2"-O-glucoside, vitexin-2"-O-rhamnoside, rutin, and hyperoside in the extract of hawthorn (Crataegus pinnatifida Bge.) leaves by RP-HPLC with ultraviolet photodiode array detection. J Sep Sci. 2007;30:717-21 pubmed
    ..of vitexin-2"-O-glucoside, vitexin-2"-O-rhamnoside, rutin, and hyperoside in the extract of hawthorn (Crataegus pinnatifida Bge.) leaves. The analytes of interest were separated on a Diamonsil C18 column (250 x 4...
  5. Leskovac A, Joksic G, Jankovic T, Savikin K, Menkovic N. Radioprotective properties of the phytochemically characterized extracts of Crataegus monogyna, Cornus mas and Gentianella austriaca on human lymphocytes in vitro. Planta Med. 2007;73:1169-75 pubmed
    The objective of the present study is to evaluate the radioprotective properties of extracts of Crataegus monogyna Jacq. (Rosaceae) fruit, Cornus mas L. (Cornaceae) leaves and Gentianella austriaca (A. Kern. & Jos. Kern...
  6. Holubarsch C, Colucci W, Meinertz T, Gaus W, Tendera M. The efficacy and safety of Crataegus extract WS 1442 in patients with heart failure: the SPICE trial. Eur J Heart Fail. 2008;10:1255-63 pubmed publisher
    b>Crataegus preparations have been used for centuries especially in Europe. To date, no proper data on their efficacy and safety as an add-on-treatment are available. Therefore a large morbidity/mortality trial was performed.
  7. Lo E, Stefanovic S, Christensen K, Dickinson T. Evidence for genetic association between East Asian and western North American Crataegus L. (Rosaceae) and rapid divergence of the eastern North American lineages based on multiple DNA sequences. Mol Phylogenet Evol. 2009;51:157-68 pubmed
    Phylogeographic relationships were constructed for 72 Old and New World Crataegus species using combinations of four chloroplast and up to five nuclear regions...
  8. Chang Q, Zuo Z, Ho W, Chow M. Comparison of the pharmacokinetics of hawthorn phenolics in extract versus individual pure compound. J Clin Pharmacol. 2005;45:106-12 pubmed
    ..The results showed that an herbal extract formulation, when administered intravenously, could potentially alter the pharmacokinetics of its active ingredients...
  9. Elango C, Jayachandaran K, Niranjali Devaraj S. Hawthorn extract reduces infarct volume and improves neurological score by reducing oxidative stress in rat brain following middle cerebral artery occlusion. Int J Dev Neurosci. 2009;27:799-803 pubmed publisher
    In our present investigation the neuroprotective effect of alcoholic extract of Hawthorn (Crataegus oxycantha) was evaluated against middle cerebral artery occlusion induced ischemia/reperfusion injury in rats...

More Information

Publications68

  1. Veveris M, Koch E, Chatterjee S. Crataegus special extract WS 1442 improves cardiac function and reduces infarct size in a rat model of prolonged coronary ischemia and reperfusion. Life Sci. 2004;74:1945-55 pubmed
    In Germany, hydroalcoholic extracts from hawthorn (Crataegus spp.) leaves with flowers are approved drugs for the treatment of mild forms of heart insufficiency...
  2. Eaton L, Kinkade S. Hawthorn extract improves chronic heart failure. J Fam Pract. 2003;52:753-4 pubmed
  3. Shahat A, Cos P, De Bruyne T, Apers S, Hammouda F, Ismail S, et al. Antiviral and antioxidant activity of flavonoids and proanthocyanidins from Crataegus sinaica. Planta Med. 2002;68:539-41 pubmed
    ..and antioxidant activity of some fractions and of a series of flavonoids and proanthocyanidins obtained from Crataegus sinaica (Rosaceae) was evaluated...
  4. Dalli E, Colomer E, Tormos M, Cosin Sales J, Milara J, Esteban E, et al. Crataegus laevigata decreases neutrophil elastase and has hypolipidemic effect: a randomized, double-blind, placebo-controlled trial. Phytomedicine. 2011;18:769-75 pubmed publisher
    b>Crataegus laevigata is a medicinal plant most commonly used for the treatment of heart failure and psychosomatic disorders...
  5. García Mateos R, Aguilar Santelises L, Soto Hernández M, Nieto Angel R. Flavonoids and antioxidant activity of flowers of Mexican Crataegus spp. Nat Prod Res. 2013;27:834-6 pubmed publisher
    Flavonoids and antioxidant activity of extracts of flowers from some Mexican accessions of Crataegus were studied using six accessions with the purpose of contributing to the knowledge of the nutraceutical properties of the accessions of ..
  6. Bubik M, Willer E, Bihari P, Jürgenliemk G, Ammer H, Krombach F, et al. A novel approach to prevent endothelial hyperpermeability: the Crataegus extract WS® 1442 targets the cAMP/Rap1 pathway. J Mol Cell Cardiol. 2012;52:196-205 pubmed publisher
    ..We hypothesized that the hawthorn (Crataegus spp...
  7. Bahorun T, Aumjaud E, Ramphul H, Rycha M, Luximon Ramma A, Trotin F, et al. Phenolic constituents and antioxidant capacities of Crataegus monogyna (Hawthorn) callus extracts. Nahrung. 2003;47:191-8 pubmed
    b>Crataegus (Hawthorn) has long been used as a folk medicine and is widely utilized in pharmaceutical preparations mainly because of its neuro- and cardiosedative actions and its low toxicity...
  8. Kao E, Wang C, Lin W, Yin Y, Wang C, Tseng T. Anti-inflammatory potential of flavonoid contents from dried fruit of Crataegus pinnatifida in vitro and in vivo. J Agric Food Chem. 2005;53:430-6 pubmed
    The dried fruits of Crataegus pinnatifida, a local soft drink material and medical herb, demonstrated antioxidant effect in a previous study...
  9. Koch E, Malek F. Standardized extracts from hawthorn leaves and flowers in the treatment of cardiovascular disorders--preclinical and clinical studies. Planta Med. 2011;77:1123-8 pubmed publisher
    Extracts from different parts of hawthorn plants (Crataegus spp.) are used worldwide for the treatment of cardiovascular diseases...
  10. Degenring F, Suter A, Weber M, Saller R. A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan) in the treatment of patients with congestive heart failure NYHA II. Phytomedicine. 2003;10:363-9 pubmed
    ..of Good Clinical Practice (GCP) shows the efficacy and safety of a standardised extract of fresh berries of Crataegus oxyacantha L. and monogyna Jacq. (Crataegisan) in patients with cardiac failure NYHA class II...
  11. Daniele C, Mazzanti G, Pittler M, Ernst E. Adverse-event profile of Crataegus spp.: a systematic review. Drug Saf. 2006;29:523-35 pubmed
    b>Crataegus spp. (hawthorn) monopreparations are predominantly used for treating congestive heart failure...
  12. Schroder D, Weiser M, Klein P. Efficacy of a homeopathic Crataegus preparation compared with usual therapy for mild (NYHA II) cardiac insufficiency: results of an observational cohort study. Eur J Heart Fail. 2003;5:319-26 pubmed
    To compare the efficacy of the homeopathic Crataegus preparation Cralonin for non-inferiority to standard treatment for mild cardiac insufficiency.
  13. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders. Curr Med Res Opin. 2004;20:63-71 pubmed
    To assess the clinical efficacy of a neurotonic component containing fixed quantities of two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium versus placebo in mild-to-moderate anxiety disorders with ..
  14. Zhang D, Zhang Y, Yin J, Zhao B. Oral administration of Crataegus flavonoids protects against ischemia/reperfusion brain damage in gerbils. J Neurochem. 2004;90:211-9 pubmed
    ..e. Crataegus flavonoids (CF), on brain ischemic insults were investigated in Mongolian gerbil stroke model...
  15. Zhang P, Xu S. C-glucoside flavonoids from the leaves of Crataegus pinnatifida Bge. var. major N.E.Br. J Asian Nat Prod Res. 2003;5:131-6 pubmed
    ..6"-O-acetylvitexin, 2-O-acetylvitexin, and 2"-O-rhamnosylvitexin were isolated from the leaves of Crataegus pinnatifida Bge. var. major N.E.Br. Their structures were elucidated by spectroscopic means and chemical evidence...
  16. Asgary S, Naderi G, Sadeghi M, Kelishadi R, Amiri M. Antihypertensive effect of Iranian Crataegus curvisepala Lind.: a randomized, double-blind study. Drugs Exp Clin Res. 2004;30:221-5 pubmed
    ..was to investigate the potential antihypertensive effects of extracts of the flavonoid-rich Iranian flower, Crataegus curvisepala Lind., a member of the Rosaceae family...
  17. Jayachandran K, Khan M, Selvendiran K, Devaraj S, Kuppusamy P. Crataegus oxycantha extract attenuates apoptotic incidence in myocardial ischemia-reperfusion injury by regulating Akt and HIF-1 signaling pathways. J Cardiovasc Pharmacol. 2010;56:526-31 pubmed publisher
    The objective of the present study was to evaluate the efficacy and mechanism of Crataegus oxycantha (COC) extract in preventing ischemia-reperfusion (IR) injury in an in vivo rat model of acute myocardial infarction induced by a 30-..
  18. Anselm E, Socorro V, Dal Ros S, Schott C, Bronner C, Schini Kerth V. Crataegus special extract WS 1442 causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of endothelial NO synthase but not via activation of estrogen receptors. J Cardiovasc Pharmacol. 2009;53:253-60 pubmed publisher
    This study determined whether the Crataegus (Hawthorn species) special extract WS 1442 stimulates the endothelial formation of nitric oxide (NO), a vasoprotective factor, and characterized the underlying mechanism.
  19. Jayalakshmi R, Thirupurasundari C, Devaraj S. Pretreatment with alcoholic extract of Crataegus oxycantha (AEC) activates mitochondrial protection during isoproterenol - induced myocardial infarction in rats. Mol Cell Biochem. 2006;292:59-67 pubmed
    b>Crataegus oxycantha (hawthorn) is used in herbal and homeopathic medicine as a cardiotonic...
  20. Zumdick S, Petereit F, Luftmann H, Hensel A. Preparative isolation of oligomeric procyanidins from Hawthorn (Crataegus spp.). Pharmazie. 2009;64:286-8 pubmed
    ..Exact mass measurements with negative ESI-TOF/MS were employed to confirm the respective structures of the isolated procyanidins...
  21. Long S, Carey R, Crofoot K, Proteau P, Filtz T. Effect of hawthorn (Crataegus oxycantha) crude extract and chromatographic fractions on multiple activities in a cultured cardiomyocyte assay. Phytomedicine. 2006;13:643-50 pubmed
    Extracts of hawthorn (Crataegus oxycantha) have become popular herbal supplements for their well-recognized cardiotonic effects...
  22. Urbonaviciūte A, Jakstas V, Kornysova O, Janulis V, Maruska A. Capillary electrophoretic analysis of flavonoids in single-styled hawthorn (Crataegus monogyna Jacq.) ethanolic extracts. J Chromatogr A. 2006;1112:339-44 pubmed
    ..Aqueous ethanolic extracts of single-styled hawthorn (Crataegus monogyna Jacq., f.: Rosaceae Juss...
  23. Ljubuncic P, Portnaya I, Cogan U, Azaizeh H, Bomzon A. Antioxidant activity of Crataegus aronia aqueous extract used in traditional Arab medicine in Israel. J Ethnopharmacol. 2005;101:153-61 pubmed
    The medicinal use of extracts prepared from plant parts of the genus Crataegus dates back to ancient times. Furthermore, it has been proposed that its antioxidant constituents account for its beneficial therapeutic effects...
  24. Kirakosyan A, Seymour E, Kaufman P, Warber S, Bolling S, Chang S. Antioxidant capacity of polyphenolic extracts from leaves of Crataegus laevigata and Crataegus monogyna (Hawthorn) subjected to drought and cold stress. J Agric Food Chem. 2003;51:3973-6 pubmed
    b>Crataegus laevigata and Crataegus monogyna (hawthorn) were subjected to drought and cold stress treatments, and polyphenolic extracts from control and stress-treated plants were assayed for antioxidant capacities using a modified version ..
  25. Nojima S, Linn C, Morris B, Zhang A, Roelofs W. Identification of host fruit volatiles from hawthorn (Crataegus spp.) attractive to hawthorn-origin Rhagoletis pomonella flies. J Chem Ecol. 2003;29:321-36 pubmed
    ..with electroantennographic detection (GC-EAD) were used to identify volatile compounds from hawthorn fruit (Crataegus spp.) acting as behavioral attractants for hawthorn-infesting Rhagoletis pomonella flies...
  26. Svedström U, Vuorela H, Kostiainen R, Huovinen K, Laakso I, Hiltunen R. High-performance liquid chromatographic determination of oligomeric procyanidins from dimers up to the hexamer in hawthorn. J Chromatogr A. 2002;968:53-60 pubmed
    ..The correlation coefficients of calibration curves were between 0.997 and 1.000. The limits of quantitation for different procyanidin standards were 0.05-0.12 mg/ml, when 10 microl of each standard solution was injected into the HPLC...
  27. Benmalek Y, Yahia O, Belkebir A, Fardeau M. Anti-microbial and anti-oxidant activities of Illicium verum, Crataegus oxyacantha ssp monogyna and Allium cepa red and white varieties. Bioengineered. 2013;4:244-8 pubmed publisher
    Illicium verum (badiane or star anise), Crataegus oxyacantha ssp monogyna (hawthorn) and Allium cepa (onion), have traditionnally been used as medicinal plants in Algeria...
  28. Walker A, Marakis G, Simpson E, Hope J, Robinson P, Hassanein M, et al. Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomised controlled trial. Br J Gen Pract. 2006;56:437-43 pubmed
    Hawthorn (Crataegus laevigata) leaves, flowers and berries are used by herbal practitioners in the UK to treat hypertension in conjunction with prescribed drugs. Small-scale human studies support this approach.
  29. Tankanow R, Tamer H, Streetman D, Smith S, Welton J, Annesley T, et al. Interaction study between digoxin and a preparation of hawthorn (Crataegus oxyacantha). J Clin Pharmacol. 2003;43:637-42 pubmed
    ..25 mg alone (D) for 10 days and digoxin 0.25 mg with Crataegus special extract WS 1442 (hawthorn leaves with flowers; Dr...
  30. Bernatoniene J, Trumbeckaite S, Majiene D, Baniene R, Baliutyte G, Savickas A, et al. The effect of crataegus fruit extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart. Phytother Res. 2009;23:1701-7 pubmed publisher
    b>Crataegus (Hawthorn) fruit extracts (CE) are widely used for the treatment of various cardiovascular diseases (arrhythmias, heart failure, myocardial weakness, etc)...
  31. Zhang J, Liang R, Wang L, Yan R, Hou R, Gao S, et al. Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats. J Ethnopharmacol. 2013;148:563-9 pubmed publisher
    ..For example, the fruit of Crataegus pinnatifida Bge. and Crataegus pinnatifida Bge. var. major N.E.Br...
  32. Tabach R, Rodrigues E, Carlini E. Preclinical toxicological assessment of a phytotherapeutic product--CPV (based on dry extracts of Crataegus oxyacantha L., Passiflora incarnata L., and Valeriana officinalis L.). Phytother Res. 2009;23:33-40 pubmed publisher
    ..The objective of this study is to assess the level of toxicity of an association of three plants: Crataegus oxyacantha, Passiflora incarnata, and Valeriana officinalis (CPV extract)...
  33. Wang T, An Y, Zhao C, Han L, Boakye Yiadom M, Wang W, et al. Regulation effects of Crataegus pinnatifida leaf on glucose and lipids metabolism. J Agric Food Chem. 2011;59:4987-94 pubmed publisher
    The leaf of Crataegus pinnatifida (Rosaceae) is commonly consumed either raw or cooked to improve digestion and promote blood circulation in China...
  34. Shin H, Lee J, Park S, Yang J, Kim J, Yi T. Hair growth activity of Crataegus pinnatifida on C57BL/6 mouse model. Phytother Res. 2013;27:1352-7 pubmed publisher
    b>Crataegus pinnatifida has a long history of use in traditional oriental herbal medicine to stimulating digestion and improving blood circulation. Based on nutrition of hair, the present study was conducted to assess the effect of C...
  35. Walker A, Marakis G, Morris A, Robinson P. Promising hypotensive effect of hawthorn extract: a randomized double-blind pilot study of mild, essential hypertension. Phytother Res. 2002;16:48-54 pubmed
    ..094) was also observed in those taking hawthorn compared with the other groups. These findings warrant further study, particularly in view of the low dose of hawthorn extract used...
  36. Chang Q, Zuo Z, Harrison F, Chow M. Hawthorn. J Clin Pharmacol. 2002;42:605-12 pubmed
    A review with 54 references covers all aspects of hawthorn, the genus Crataegus, including its traditional uses, chemical constituents, pharmacological activities, and clinical effects...
  37. Vierling W, Brand N, Gaedcke F, Sensch K, Schneider E, Scholz M. Investigation of the pharmaceutical and pharmacological equivalence of different Hawthorn extracts. Phytomedicine. 2003;10:8-16 pubmed
    ..It is thus possible to obtain bioequivalent extracts with comparable effect profiles by using 40 to 70% ethanol or methanol as the extraction solvent...
  38. Littleton R, Miller M, Hove J. Whole plant based treatment of hypercholesterolemia with Crataegus laevigata in a zebrafish model. BMC Complement Altern Med. 2012;12:105 pubmed publisher
    ..Here we develop the larval zebrafish (4-30 days post fertilization) as a vertebrate model of dietary plant-based treatment of hypercholesterolemia and test the effects of Crataegus laevigata in this model.
  39. Mayer C, Jarausch B, Jarausch W, Jelkmann W, Vilcinskas A, Gross J. Cacopsylla melanoneura has no relevance as vector of apple proliferation in Germany. Phytopathology. 2009;99:729-38 pubmed publisher
    ..melanoneura developed on either apple or hawthorn has no relevance as a vector of apple proliferation in Germany. The existence of epidemiologically different populations is proposed...
  40. Talent N, Dickinson T. Endosperm formation in aposporous Crataegus (Rosaceae, Spiraeoideae, tribe Pyreae): parallels to Ranunculaceae and Poaceae. New Phytol. 2007;173:231-49 pubmed
    Apomixis in Crataegus is primarily aposporous and requires pollination. The embryo sac is of the Polygonum type...
  41. Lo E, Stefanovic S, Dickinson T. Population genetic structure of diploid sexual and polyploid apomictic hawthorns (Crataegus; Rosaceae) in the Pacific Northwest. Mol Ecol. 2009;18:1145-60 pubmed publisher
    ..However, the population genetic structure of these species is poorly understood. Crataegus douglasii is represented exclusively by self-compatible tetraploid pseudogamous apomicts across North America, ..
  42. Chang W, Dao J, Shao Z. Hawthorn: potential roles in cardiovascular disease. Am J Chin Med. 2005;33:1-10 pubmed
    Hawthorn (Crataegus) may play a role in the prevention and treatment of cardiovascular diseases such as hypertension, hyperlipidemia, and in particular, congestive heart failure...
  43. Bernatoniene J, Masteikova R, Majiene D, Savickas A, Kevelaitis E, Bernatoniene R, et al. Free radical-scavenging activities of Crataegus monogyna extracts. Medicina (Kaunas). 2008;44:706-12 pubmed
    ..The aim of this study was to investigate antiradical activity of aqueous and ethanolic hawthorn fruit extracts, their flavonoids, and flavonoid combinations...
  44. Shin I, Lee M, Lim H, Ha H, Seo C, Kim J, et al. An extract of Crataegus pinnatifida fruit attenuates airway inflammation by modulation of matrix metalloproteinase-9 in ovalbumin induced asthma. PLoS ONE. 2012;7:e45734 pubmed publisher
    b>Crataegus pinnatifida (Chinese hawthorn) has long been used as a herbal medicine in Asia and Europe...
  45. Belz G, Loew D. Dose-response related efficacy in orthostatic hypotension of a fixed combination of D-camphor and an extract from fresh crataegus berries and the contribution of the single components. Phytomedicine. 2003;10 Suppl 4:61-7 pubmed
    ..randomized, placebo-controlled studies using sublingual/oral administration of D-camphor, an extract from fresh crataegus berries, and a combination of the two (CCC) yielded the following results: Both the D-camphor and the extract ..
  46. Rietbrock N, Hamel M, Hempel B, Mitrovic V, Schmidt T, Wolf G. [Actions of standardized extracts of Crataegus berries on exercise tolerance and quality of life in patients with congestive heart failure]. Arzneimittelforschung. 2001;51:793-8 pubmed
    Standardized extracts of Crataegus leaves and blossoms are said to have positive inotropic, positive dromotropic and negative bathmotropic effects...
  47. Zick S, Gillespie B, Aaronson K. The effect of Crataegus oxycantha Special Extract WS 1442 on clinical progression in patients with mild to moderate symptoms of heart failure. Eur J Heart Fail. 2008;10:587-93 pubmed publisher
    To examine whether hawthorn (Crataegus Special Extract WS 1442 {CSE}) inhibits progression in heart failure (HF) patients.
  48. Chu C, Lee M, Liao C, Lin W, Yin Y, Tseng T. Inhibitory effect of hot-water extract from dried fruit of Crataegus pinnatifida on low-density lipoprotein (LDL) oxidation in cell and cell-free systems. J Agric Food Chem. 2003;51:7583-8 pubmed
    The dried fruit of Crataegus pinnatifida, a local soft drink material and medical herb, was found to possess potential against oxidative stress...
  49. Rigelsky J, Sweet B. Hawthorn: pharmacology and therapeutic uses. Am J Health Syst Pharm. 2002;59:417-22 pubmed
    ..Hawthorn (Crataegus oxyacantha) is a fruit-bearing shrub with a long history as a medicinal substance...
  50. Tadić V, Dobric S, Marković G, Dordević S, Arsić I, Menković N, et al. Anti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities of hawthorn berries ethanol extract. J Agric Food Chem. 2008;56:7700-9 pubmed publisher
    Hawthorn [Crataegus monogyna Jacq. and Crataegus oxyacantha L.; sin. Crataegus laevigata (Poiret) DC...
  51. Niu C, Chen C, Chen L, Cheng K, Yeh C, Cheng J. Decrease of blood lipids induced by Shan-Zha (fruit of Crataegus pinnatifida) is mainly related to an increase of PPAR? in liver of mice fed high-fat diet. Horm Metab Res. 2011;43:625-30 pubmed publisher
    ..Shan-Zha (Crataegus pinnatifida) is a traditional Chinese medicine used to increase digestion...
  52. Sobral M, Guitián J, Guitián P, Larrinaga A. Selective pressure along a latitudinal gradient affects subindividual variation in plants. PLoS ONE. 2013;8:e74356 pubmed publisher
    ..Here we investigated this idea and we found that subindividual variation of fruit size of Crataegus monogyna, in different populations throughout the latitudinal gradient in Europe, was explained at some extent ..
  53. Han F, Guo Y, Gu H, Li F, Hu B, Yang L. Application of alkyl polyglycoside surfactant in ultrasonic-assisted extraction followed by macroporous resin enrichment for the separation of vitexin-2″-O-rhamnoside and vitexin from Crataegus pinnatifida leaves. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1012-1013:69-78 pubmed publisher
    ..ultrasonic-assisted extraction to effectively extract vitexin-2″-O-rhamnoside (VOR) and vitexin (VIT) from Crataegus pinnatifida leaves. APG0810 was selected as the surfactant...
  54. Pahlavan S, Tousi M, Ayyari M, Alirezalu A, Ansari H, Saric T, et al. Effects of hawthorn (Crataegus pentagyna) leaf extract on electrophysiologic properties of cardiomyocytes derived from human cardiac arrhythmia-specific induced pluripotent stem cells. FASEB J. 2017;: pubmed publisher
    ..Here we studied the cardiac effects of hawthorn (Crataegus pentagyna) leaf extract using cardiomyocytes (CMs) differentiated from healthy human embryonic stem cells, ..
  55. Al Hallaq E, Afifi F, Abdalla S. Evaluation of the hypocholesterolemic effect and phytochemical screening of the hydroethanolic extract of Crataegus aronia from Jordan. Nat Prod Commun. 2012;7:35-8 pubmed
    Chemical screening of the leaves and flowers of Crataegus aronia resulted in the isolation of hyperoside, quercetin, rutin and beta-sitosterol for the first time from this plant. The effects of the hydroethanolic extract of C...
  56. Habs M. Prospective, comparative cohort studies and their contribution to the benefit assessments of therapeutic options: heart failure treatment with and without Hawthorn special extract WS 1442. Forsch Komplementarmed Klass Naturheilkd. 2004;11 Suppl 1:36-9 pubmed
    ..cohort study (Efficacy and socio-economic relevance of treatment of chronic heart failure stage NYHA II with Crataegus extract WS 1442)...
  57. Tedeschi R, Nardi F. DNA-based discrimination and frequency of phytoplasma infection in the two hawthorn-feeding species, Cacopsylla melanoneura and Cacopsylla affinis, in northwestern Italy. Bull Entomol Res. 2010;100:741-7 pubmed publisher
    ..Our preliminary observations suggest that some differences might exist between the two genetic variants in their ability to transmit phytoplasmas and to colonise different host plants. ..
  58. Ying X, Wang F, Cheng Z, Zhang W, Li H, Du Y, et al. Pharmacokinetics of vitexin-4?-O-glucoside in rats after intravenous application. Eur J Drug Metab Pharmacokinet. 2012;37:109-15 pubmed publisher
    Vitexin-4?-O-glucoside (VOG), being a main component in the leaves of Crataegus pinnatifida Bge. var. major, was isolated and then three different doses (20, 40, and 60 mg/kg) of VOG were administered intravenously to rats...
  59. Kjaer C, Strandberg M, Erlandsen M. Metsulfuron spray drift reduces fruit yield of hawthorn (Crataegus monogyna L.). Sci Total Environ. 2006;356:228-34 pubmed
    ..was carried out to investigate whether spray drift of metsulfuron has a potential to negatively affect hawthorn (Crataegus monogyna) hedgerows near agricultural fields...