Summary: A plant genus of the family RHAMNACEAE. Members contain nummularogenin (a spirostane) and is the source of an edible fruit.

Top Publications

  1. Jiang J, Huang X, Chen J. Separation and purification of saponins from Semen Ziziphus jujuba and their sedative and hypnotic effects. J Pharm Pharmacol. 2007;59:1175-80 pubmed
    Semen Ziziphus jujuba (SZJ) has long been used in Chinese traditional medicine for the treatment of anxiety and insomnia because of its effect of decreasing monoaminergic system activity; saponins are thought to be the main bioactive ..
  2. Wu H, Chen J, Liu Y. [Studies on HPLC-FPS of the saponins from Semen Ziziphi Spinosae]. Zhong Yao Cai. 2006;29:900-3 pubmed
    ..All components in the spectrum were separated well and the HPLC fingerprint method is repeatable. The method can be used in quality assessment of SZS. ..
  3. Gupta M, Mazumder U, Vamsi M, Sivakumar T, Kandar C. Anti-steroidogenic activity of the two Indian medicinal plants in mice. J Ethnopharmacol. 2004;90:21-5 pubmed
    ..Normal estrus cycle and ovarian steroidogenisis were restored after withdrawal of treatment with CECR and EAZJ on average 27 and 32 days, respectively. Antifertility activities of crude extracts were found to be reversible. ..
  4. Bai Y, Cheng G, Tao J, Wang B, Zhao Y, Liu Y, et al. [Structure identification of jujuboside E]. Yao Xue Xue Bao. 2003;38:934-7 pubmed
    To study the chemical constituents of the seeds of Ziziphus jujuba Mill var. spinosa (Bunge) Hu ex. H.F. Chou...
  5. Wahida B, Abderrahman B, Nabil C. Antiulcerogenic activity of Zizyphus lotus (L.) extracts. J Ethnopharmacol. 2007;112:228-31 pubmed
    ..Thus, Zizyphus lotus extracts act essentially as cytoprotective agents, which support the antiulcer effect of this plant in the traditional medicine...
  6. Borgi W, Ghedira K, Chouchane N. Antiinflammatory and analgesic activities of Zizyphus lotus root barks. Fitoterapia. 2007;78:16-9 pubmed
    ..Aqueous extract (50, 100 and 200 mg/kg) given intraperitoneally (i.p.) showed a significant and dose-dependent antiinflammatory and analgesic activity...
  7. Zhang H, Jiang L, Ye S, Ye Y, Ren F. Systematic evaluation of antioxidant capacities of the ethanolic extract of different tissues of jujube (Ziziphus jujuba Mill.) from China. Food Chem Toxicol. 2010;48:1461-5 pubmed publisher
    Jujube (Ziziphus jujuba Mill.) has long been used for human consumption and medicinal purposes in China. It is recommended for some diseases in which radical species are produced as a result of oxidative stress...
  8. Su B, Cuendet M, Farnsworth N, Fong H, Pezzuto J, Kinghorn A. Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. Planta Med. 2002;68:1125-8 pubmed
    Bioactivity-guided fractionation of petroleum ether- and EtOAc-soluble extracts of the seeds of Ziziphus jujuba using a cyclooxygenase-2 assay as a monitor indicated that the triglyceride, 1,3-di-O-[9(Z)-octadecenoyl]-2-O-[9(Z),12(Z)-..
  9. Lahlou M, El Mahi M, Hamamouchi J. [Evaluation of antifungal and mollusuicidial activities of Moroccan Zizyphus lotus (L.) Desf]. Ann Pharm Fr. 2002;60:410-4 pubmed
    ..Whereas, methanolic extract was found to possess the strong mollusuicidial activity and exhibited potent "knock-down" effect on molluscans related to its countenance on saponins...

More Information

Publications133 found, 100 shown here

  1. Zhao J, Li S, Yang F, Li P, Wang Y. Simultaneous determination of saponins and fatty acids in Ziziphus jujuba (Suanzaoren) by high performance liquid chromatography-evaporative light scattering detection and pressurized liquid extraction. J Chromatogr A. 2006;1108:188-94 pubmed
    The seed of Ziziphus jujube Mill. var. spinosa (Bunge) Hu ex H. F. Chou, Suanzaoren in Chinese, is one of commonly used Chinese medicines...
  2. Bachaya H, Iqbal Z, Khan M, Sindhu Z, Jabbar A. Anthelmintic activity of Ziziphus nummularia (bark) and Acacia nilotica (fruit) against Trichostrongylid nematodes of sheep. J Ethnopharmacol. 2009;123:325-9 pubmed publisher
    b>Ziziphus nummularia (Rhamnaceae) and Acacia nilotica (Fabaceae) are being used as anthelmintics in ethnoveterinary medicinal system of Pakistan.
  3. Bhatia A, Mishra T. Hypoglycemic activity of Ziziphus mauritiana aqueous ethanol seed extract in alloxan-induced diabetic mice. Pharm Biol. 2010;48:604-10 pubmed publisher
    b>Ziziphus mauritiana Lamk. (Rhamnaceae) is a fruit tree that has been used as folkloric medicine for many ailments and diseases...
  4. Cheng D, Zhu C, Cao J, Jiang W. The protective effects of polyphenols from jujube peel (Ziziphus Jujube Mill) on isoproterenol-induced myocardial ischemia and aluminum-induced oxidative damage in rats. Food Chem Toxicol. 2012;50:1302-8 pubmed publisher
    This study was aimed to evaluate the preventive effect of the polyphenols from Chinese jujube peel (Ziziphus jujube Mill. cv. Dongzao) against myocardial injury (MI) induced by isoproterenol (ISO) and biotoxicity of aluminum in rats...
  5. Gao Q, Wu C, Wang M. The jujube (Ziziphus jujuba Mill.) fruit: a review of current knowledge of fruit composition and health benefits. J Agric Food Chem. 2013;61:3351-63 pubmed publisher
    The nutritional jujube ( Ziziphus jujube Mill.) fruit belonging to the Rhamnaceous family grows mostly in Europe, southern and eastern Asia, and Australia, especially the inland region of northern China...
  6. Memon A, Memon N, Bhanger M, Luthria D. Assay of phenolic compounds from four species of ber (Ziziphus mauritiana L.) fruits: comparison of three base hydrolysis procedure for quantification of total phenolic acids. Food Chem. 2013;139:496-502 pubmed publisher
    The present study was undertaken to investigate the flavonoid profile in four species of ber (Ziziphus mauritiana Lamk.) fruit...
  7. Yang B, Yang H, Chen F, Hua Y, Jiang Y. Phytochemical analyses of Ziziphus jujuba Mill. var. spinosa seed by ultrahigh performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. Analyst. 2013;138:6881-8 pubmed publisher
    b>Ziziphus jujuba Mill. var. spinosa (Z. jujuba) seeds have attracted much attention within the field of medicine due to their significant effects against disturbances of the central nervous system...
  8. Jiang J, Huang X, Chen J, Lin Q. Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube. Nat Prod Res. 2007;21:310-20 pubmed
    Semen Ziziphus jujube (SZJ), the seeds of Ziziphus jujuba Mill. var. spinosa, is a kind of traditional Chinese medicine used for its action on insomnia...
  9. Zhang M, Zhang Y, Xie J. Simultaneous determination of jujuboside A, B and betulinic acid in semen Ziziphi spinosae by high performance liquid chromatography-evaporative light scattering detection. J Pharm Biomed Anal. 2008;48:1467-70 pubmed publisher
    ..Quantification of the three active compounds in semen Ziziphi spinosae from different locations was performed by this method, which provides a new tool for quality assessment of semen Ziziphi spinosae...
  10. Guo S, Duan J, Tang Y, Qian D, Zhu Z, Qian Y, et al. UHPLC-TOFMS coupled with chemometric method as a powerful technique for rapid exploring of differentiating components between two Ziziphus species. J Sep Sci. 2011;34:659-66 pubmed publisher
    ..UHPLC)-TOFMS coupled with multivariate statistical analysis method was proposed and validated by using two Ziziphus species (Z. jujuba and Z. jujuba var. spinosa) as the model herbs...
  11. Edwards C, Parchman T, Weekley C. Assembly, gene annotation and marker development using 454 floral transcriptome sequences in Ziziphus celata (Rhamnaceae), a highly endangered, Florida endemic plant. DNA Res. 2012;19:1-9 pubmed publisher
    ..b>Ziziphus celata, a federally endangered, self-incompatible plant species occurring in Florida, USA, is one species for ..
  12. Gao Q, Wu C, Yu J, Wang M, Ma Y, Li C. Textural characteristic, antioxidant activity, sugar, organic acid, and phenolic profiles of 10 promising jujube (Ziziphus jujuba Mill.) selections. J Food Sci. 2012;77:C1218-25 pubmed publisher
    ..Qingjianmuzao is good for direct consumption containing high levels of total soluble solids, total sugars, fructose, and glucose, while Zizyphus jujuba cv. Jiaxianmuzao could be an important dietary source of natural antioxidants...
  13. Nyanga L, Nout M, Smid E, Boekhout T, Zwietering M. Fermentation characteristics of yeasts isolated from traditionally fermented masau (Ziziphus mauritiana) fruits. Int J Food Microbiol. 2013;166:426-32 pubmed publisher
    ..The yeast species originally isolated from Ziziphus mauritiana (masau) fruits and their traditionally fermented fruit pulp in Zimbabwe were examined for their ..
  14. Nyanga L, Nout M, Gadaga T, Theelen B, Boekhout T, Zwietering M. Yeasts and lactic acid bacteria microbiota from masau (Ziziphus mauritiana) fruits and their fermented fruit pulp in Zimbabwe. Int J Food Microbiol. 2007;120:159-66 pubmed
    ..fructosus, L. fermentum and Streptococcus spp. Some of the strains of LAB could also potentially be used in a mixed-starter culture with yeasts and might contribute positively in the production of fermented masau fruit products...
  15. Li M, Yang G, Mi S, Gao X, Wang Y, Li M. [Extract process of cyclic adenosinemonophosphate (cAMP) in Ziziphus jujuba]. Zhong Yao Cai. 2007;30:1143-5 pubmed
    To study the extract process of Cyclic adenosinemonophosphate (cAMP) in Ziziphus jujuba.
  16. Mpiana P, Mudogo V, Tshibangu D, Kitwa E, Kanangila A, Lumbu J, et al. Antisickling activity of anthocyanins from Bombax pentadrum, Ficus capensis and Ziziphus mucronata: photodegradation effect. J Ethnopharmacol. 2008;120:413-8 pubmed publisher
  17. Olajuyigbe O, Afolayan A. Phenolic content and antioxidant property of the bark extracts of Ziziphus mucronata Willd. subsp. mucronata Willd. BMC Complement Altern Med. 2011;11:130 pubmed publisher
    ..Many of these plants including Ziziphus mucronata subsp. mucronata lack scientific reports to support their medicinal importance.
  18. Plastina P, Bonofiglio D, Vizza D, Fazio A, Rovito D, Giordano C, et al. Identification of bioactive constituents of Ziziphus jujube fruit extracts exerting antiproliferative and apoptotic effects in human breast cancer cells. J Ethnopharmacol. 2012;140:325-32 pubmed publisher
    b>Ziziphus extracts have been used in Traditional Chinese Medicine for the treatment of cancer.
  19. Guil Guerrero J, Díaz Delgado A, Matallana González M, Torija Isasa M. Fatty acids and carotenes in some ber (Ziziphus jujuba Mill) varieties. Plant Foods Hum Nutr. 2004;59:23-7 pubmed
    ..Carotenes were found to be in good agreement with other fruits, varying from 4.12 to 5.98 mg/100 g on a dry weight basis. The contribution to vitamin value reach a mdium of 38 microg RE/100 g on a fresh weight basis...
  20. Sun H, Meng Y, Cui G, Cao Q, Li J, Liang A. Selection of housekeeping genes for gene expression studies on the development of fruit bearing shoots in Chinese jujube (Ziziphus jujube Mill.). Mol Biol Rep. 2009;36:2183-90 pubmed publisher
    Chinese jujube (Ziziphus jujube Mill.) is important economically for its fruit and also bears attractive medical value. Its flower development concurs with the growth of current fruit bearing shoots (FBSs)...
  21. Ji C, Zeng G, Han J, He W, Zhang Y, Tan N. Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana. Bioorg Med Chem Lett. 2012;22:6377-80 pubmed publisher
    ..triterpenes ceanothenic acid (4), betulinic acid (5), and ceanothic acid (6), were isolated from the roots of Ziziphus mauritiana. Compounds 1-4 showed cytotoxicities with the IC(50) values ranging from 5.05 to 11...
  22. Kaleem W, Muhammad N, Qayum M, Khan H, Khan A, Aliberti L, et al. Antinociceptive activity of cyclopeptide alkaloids isolated from Ziziphus oxyphylla Edgew (Rhamnaceae). Fitoterapia. 2013;91:154-158 pubmed publisher
    ..The current study was designed to evaluate the antinociceptive profile of five cyclopeptide alkaloids isolated from Ziziphus oxyphylla, including Oxyphylline-B 1, Oxyphylline C 2 Oxyphylline-D 3, Nummularin-C 4, and Nummularin-R 5...
  23. Abdel Zaher A, Salim S, Assaf M, Abdel Hady R. Antidiabetic activity and toxicity of Zizyphus spina-christi leaves. J Ethnopharmacol. 2005;101:129-38 pubmed
    ..Thus, Zizyphusspina-christi leaves appears to be a safe alternative to lower blood glucose. The safe insulinotropic and subsequent hypoglycemic effects of Zizyphus spina-christi leaves may be due to a sulfonylurea-like activity...
  24. Guo S, Duan J, Tang Y, Su S, Shang E, Ni S, et al. High-performance liquid chromatography--two wavelength detection of triterpenoid acids from the fruits of Ziziphus jujuba containing various cultivars in different regions and classification using chemometric analysis. J Pharm Biomed Anal. 2009;49:1296-302 pubmed publisher
    ..ceanothenic acid, betulinic acid, oleanolic acid, ursonic acid and zizyberenalic acid) in the dried fruit of Ziziphus jujuba (called Dazao) which has been widely used as one of the traditional Chinese medicines (TCMs)...
  25. Koetter U, Barrett M, Lacher S, Abdelrahman A, Dolnick D. Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors. J Ethnopharmacol. 2009;124:421-5 pubmed publisher
    Magnolia officinalis Rehder and Wilson [Magnoliaceae] bark and Ziziphus spinosa (Buhge) Hu ex. Chen. [Fam. Rhamnaceae] seed have a history of use in traditional Asian medicine for mild anxiety, nervousness and sleep-related problems.
  26. Guo S, Duan J, Tang Y, Zhu Z, Qian Y, Yang N, et al. Characterization of nucleosides and nucleobases in fruits of Ziziphus jujuba by UPLC-DAD-MS. J Agric Food Chem. 2010;58:10774-80 pubmed publisher
    The fruit of Ziziphus jujuba , named dazao in Chinese, has been utilized as food as well as crude drugs in China for thousands of years...
  27. Mishra T, Bhatia A. Augmentation of expression of immunocytes' functions by seed extract of Ziziphus mauritiana (Lamk.). J Ethnopharmacol. 2010;127:341-5 pubmed publisher
    The present study was carried out to evaluate the immunomodulatory potential of Ziziphus mauritiana (Lamk.) seed extract to ascertain the folkloric claim as immunomodulator.
  28. Guo S, Duan J, Tang Y, Yang N, Qian D, Su S, et al. Characterization of triterpenic acids in fruits of ziziphus species by HPLC-ELSD-MS. J Agric Food Chem. 2010;58:6285-9 pubmed publisher
    The fruits of Ziziphus species have been utilized as food as well as crude drugs for their health benefits in China for thousands of years...
  29. Lee M, Chen Y, Lan J, Tseng C, Wu C. Allergenic components of Indian jujube (Zizyphus mauritiana) show IgE cross-reactivity with latex allergen. Int Arch Allergy Immunol. 2004;133:211-6 pubmed
    ..Our results add to findings regarding the 'latex-fruit syndrome' described in the literature, and further study of the cross-reacting allergens identified in Indian jujube may help to elucidate the mechanisms underlying this syndrome. ..
  30. Soman S, Ray J. Silver nanoparticles synthesized using aqueous leaf extract of Ziziphus oenoplia (L.) Mill: Characterization and assessment of antibacterial activity. J Photochem Photobiol B. 2016;163:391-402 pubmed publisher
    ..nanoparticles (AgNPs) with size of 10nm have been successfully synthesized using aqueous leaf extract (AQLE) of Ziziphus oenoplia (L.) Mill., which act as both reducing as well as capping agent...
  31. Noritake S, Liu J, Kanetake S, Levin C, Tam C, Cheng L, et al. Phytochemical-rich foods inhibit the growth of pathogenic trichomonads. BMC Complement Altern Med. 2017;17:461 pubmed publisher
  32. Yan J, Li J, Zhao H, Chen N, Cao J, Jiang W. Effects of oligochitosan on postharvest Alternaria rot, storage quality, and defense responses in Chinese jujube (Zizyphus jujuba Mill. cv. Dongzao) fruit. J Food Prot. 2011;74:783-8 pubmed publisher
    ..OCH could be a viable alternative to conventional control of postharvest diseases of horticultural products. ..
  33. Ji X, Peng Q, Yuan Y, Shen J, Xie X, Wang M. Isolation, structures and bioactivities of the polysaccharides from jujube fruit (Ziziphus jujuba Mill.): A review. Food Chem. 2017;227:349-357 pubmed publisher
    Jujube (Ziziphus Jujuba Mill.) has been eaten as a fruit and nutraceutical food in China for thousands of years...
  34. Mitsuhashi Y, Furusawa Y, Aradate T, Zhao Q, Moniruzzaman R, Kanamori M, et al. 3-O-trans-p-coumaroyl-alphitolic acid, a triterpenoid from Zizyphus jujuba, leads to apoptotic cell death in human leukemia cells through reactive oxygen species production and activation of the unfolded protein response. PLoS ONE. 2017;12:e0183712 pubmed publisher
    ..These findings reveal for the first time that 3OTPCA induces apoptotic cell death through the generation of reactive oxygen species and activation of UPR. ..
  35. Singh D, Maurya S, Singh S, Singh M, Singh U. Chemotaxonomic variability in Zizyphus mouritiana varieties and its pharmacological properties in relation to human health. J Herb Pharmacother. 2007;7:229-37 pubmed
    ..3.00 min) was also detected. Pharmacological properties of phenolic acids of fruits in relation to human health and the possible implications of different phenolic acids in chemotaxonomy of different varieties of ber are discussed. ..
  36. Yadav R, Lone S, Gaikwad K, Singh N, Padaria J. Transcriptome sequence analysis and mining of SSRs in Jhar Ber (Ziziphus nummularia (Burm.f.) Wight & Arn) under drought stress. Sci Rep. 2018;8:2406 pubmed publisher
    b>Ziziphus nummularia (Burm.f.) Wight & Arn., a perennial shrub that thrives in the arid regions, is naturally tolerant to drought. However, there are limited studies on the genomics of drought tolerance in Ziziphus sp...
  37. Yu F, Guan X, Zhao Z, Zhang M, Guo P, Pan J, et al. [Application of biogas fermentation residue in Ziziphus jujuba cultivation]. Ying Yong Sheng Tai Xue Bao. 2006;17:345-7 pubmed
    ..It was suggested that biogas fermentation residue application could bring better economic and environmental benefits for Z. jujuba cultivation, and also, provide a new approach for no-pollution production of jujube. ..
  38. Albrecht C, Pellarin M, Baronetti J, Rojas M, Albesa I, Eraso A. Chemiluminescence determination of antioxidant property of Zizyphus mistol and Prosopis alba during oxidative stress generated in blood by Hemolytic Uremic Syndrome-producing Escherichia coli. Luminescence. 2011;26:424-8 pubmed publisher
    ..Both fruits studied reduce the induction of ROS, and in this way help to prevent the development of complications related to oxidative stress generated in the blood of patients with HUS...
  39. Ji X, Liu F, Peng Q, Wang M. Purification, structural characterization, and hypolipidemic effects of a neutral polysaccharide from Ziziphus Jujuba cv. Muzao. Food Chem. 2018;245:1124-1130 pubmed publisher
    A neutral polysaccharide (PZMP1) with a molecular weight of 16.97?kDa was isolated from Ziziphus Jujuba cv...
  40. Borgi W, Chouchane N. Anti-spasmodic effects of Zizyphus lotus (L.) Desf. extracts on isolated rat duodenum. J Ethnopharmacol. 2009;126:571-3 pubmed publisher
    ..This could explain the traditional use of Zizyphus lotus in the treatment of the intestinal diseases. ..
  41. Collado González J, Cruz Z, Rodriguez P, Galindo A, Díaz Baños F, Garcia de la Torre J, et al. Effect of water deficit and domestic storage on the procyanidin profile, size, and aggregation process in pear-jujube (Z. jujuba) fruits. J Agric Food Chem. 2013;61:6187-97 pubmed publisher
    No information exists on the proanthocyanidin content of pear-jujube (Ziziphus jujuba Mill) fruit, their polymeric types and sizes, and their self-aggregation, or on the effect of different water deficit levels during the fruit maturation ..
  42. Aljabali A, Akkam Y, Al Zoubi M, Al Batayneh K, Al Trad B, Abo Alrob O, et al. Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity. Nanomaterials (Basel). 2018;8: pubmed publisher
    ..TGA analysis revealed that biomolecules, which were present in the plant extract, capped the nanoparticles and acted as stabilizing agents. ..
  43. Tel Zur N, Schneider B. Floral biology of Ziziphus mauritiana (Rhamnaceae). Sex Plant Reprod. 2009;22:73-85 pubmed publisher
    Floral development of the synchronous dichogamous species Ziziphus mauritiana, as followed by light and scanning electron microscopy (SEM), was divided into 11 stages using a series of landmark events...
  44. Zare Zardini H, Tolueinia B, Hashemi A, Ebrahimi L, Fesahat F. Antioxidant and cholinesterase inhibitory activity of a new peptide from Ziziphus jujuba fruits. Am J Alzheimers Dis Other Demen. 2013;28:702-9 pubmed publisher
    ..In this study, a new peptide from Ziziphus jujuba fruits was investigated for its inhibitory activity against acetylcholinesterase (AChE) and ..
  45. WojdyÅ‚o A, Carbonell Barrachina Ã, Legua P, Hernández F. Phenolic composition, ascorbic acid content, and antioxidant capacity of Spanish jujube (Ziziphus jujube Mill.) fruits. Food Chem. 2016;201:307-14 pubmed publisher
    The interest in Ziziphus jujube is growing because it is an excellent source of nutrients and phytochemicals, and can contribute to a healthy diet...
  46. Suksamrarn S, Panseeta P, Kunchanawatta S, Distaporn T, Ruktasing S, Suksamrarn A. Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana. Chem Pharm Bull (Tokyo). 2006;54:535-7 pubmed
    One new and eight known ceanothane- and lupane-type triterpenes were isolated from the root bark of Ziziphus cambodiana PIERRE (Rhamnaceae)...
  47. Yang H, An S, Sun O, Shi Z, She X, Sun Q, et al. Seasonal variation and correlation with environmental factors of photosynthesis and water use efficiency of Juglans regia and Ziziphus jujuba. J Integr Plant Biol. 2008;50:210-20 pubmed publisher
    Both the photosynthetic light curves and CO(2) curves of Juglans regia L. and Ziziphus jujuba Mill. var. spinosa in three seasons were measured using a LI-6400 portable photosynthesis system...
  48. Fatima I, Waheed S, Zaidi J. Essential and toxic elements in three Pakistan's medicinal fruits (Punica granatum, Ziziphus jujuba and Piper cubeba) analysed by INAA. Int J Food Sci Nutr. 2012;63:310-7 pubmed publisher
    ..and minor trace elements (essential, toxic and non-essential) were identified in Punica granatum (pomegranate), Ziziphus jujuba (jujube) and Piper cubeba L. (cubeb) by employing instrumental neutron activation analysis technique...
  49. Nyanga L, Gadaga T, Nout M, Smid E, Boekhout T, Zwietering M. Nutritive value of masau (Ziziphus mauritiana) fruits from Zambezi Valley in Zimbabwe. Food Chem. 2013;138:168-72 pubmed publisher
    b>Ziziphus mauritiana (masau) fruits are consumed by many people in Zimbabwe. The fruits contribute significantly to people's diet when they are in season...
  50. Pellarín M, Albrecht C, Rojas M, Aguilar J, Konigheim B, Paraje M, et al. Inhibition of cytotoxicity of Shiga toxin of Escherichia coli O157:H7 on vero cells by Prosopis alba Griseb (Fabaceae) and Ziziphus mistol Griseb (Rhamnaceae) extracts. J Food Prot. 2013;76:1733-9 pubmed publisher
    The capacity of Prosopis alba Griseb. and Ziziphus mistol Griseb. fruit extracts to inhibit the toxic action of Shiga toxin (Stx) was investigated...
  51. Maciuk A, Lavaud C, Thépenier P, Jacquier M, Ghedira K, Zèches Hanrot M. Four new dammarane saponins from Zizyphus lotus. J Nat Prod. 2004;67:1639-43 pubmed
  52. Shi G, Wang Y, Miao Z, Li D, Zhang T, Yu T, et al. [Community structure and its dynamics of predatory arthropod in jujube orchards intercropped with different herbage species]. Ying Yong Sheng Tai Xue Bao. 2006;17:2088-92 pubmed
    ..05) than that of predatory insects in all test jujube orchards. The individuals of Coccinellidae, Pentatomidae, inoccllidae, Chrysopidae, Thomisidae, Araneidae and Phytoseiidae played the dominant role in the community. ..
  53. He L, Shen P, Fu Q, Li J, Dan M, Wang X, et al. Nephro-protective effect of Kangqianling decoction on chronic renal failure rats. J Ethnopharmacol. 2009;122:367-73 pubmed publisher
    ..The results indicate that KQL is able to protect renal function via ameliorating experimental rat renal failure as found in these renal functional parameters. ..
  54. Li J, Ai L, Yang Q, Liu Y, Shan L. Isolation and structural characterization of a polysaccharide from fruits of Zizyphus jujuba cv. Junzao. Int J Biol Macromol. 2013;55:83-7 pubmed publisher
    ..The branches were composed of 1,5-L-Araf, 1,3,5-L-Araf, 1,3-L-Araf, 1,6-D-Galp, 1,4,6-D-Galp and 1,4-D-Glcp. The branches were attached to the backbone at the O-4 position of Rhap residues. ..
  55. Singh J, Dentino A, Maki J. Can jua be a weapon in combating oral diseases?. Gen Dent. 2007;55:559-63 pubmed
    ..This article presents information about the Ziziphus joazeiro plant, its medicinal use, and its chemical components while also reviewing the literature concerning Jua ..
  56. Kubota H, Morii R, Kojima Yuasa A, Huang X, Yano Y, Matsui Yuasa I. Effect of Zizyphus jujuba extract on the inhibition of adipogenesis in 3T3-L1 preadipocytes. Am J Chin Med. 2009;37:597-608 pubmed
    ..These results suggest that CHCl(3)-F may block adipogenesis, at least in part, by decreasing the expression of PPARgamma, C/EBPalpha and beta. ..
  57. Olajuyigbe O, Afolayan A. Evaluation of combination effects of ethanolic extract of Ziziphus mucronata Willd. subsp. mucronata Willd. and antibiotics against clinically important bacteria. ScientificWorldJournal. 2013;2013:769594 pubmed publisher
    ..This study evaluated the interactions between the ethanolic bark extract of Ziziphus mucronata with known antimicrobial agents in vitro...
  58. Xu M, Lee S, Kang S, Kim Y. Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy. J Nat Prod. 2014;77:370-6 pubmed publisher
    ..Taken together, these results demonstrate that 1 induced protective autophagy to retard extrinsic pathway-mediated apoptosis. ..
  59. Amin A, Mahmoud Ghoneim D. Zizyphus spina-christi protects against carbon tetrachloride-induced liver fibrosis in rats. Food Chem Toxicol. 2009;47:2111-9 pubmed publisher
    ..These results demonstrate that administration of ZSC may be useful in the treatment and prevention of hepatic fibrosis. ..
  60. Al Reza S, Bajpai V, Kang S. Antioxidant and antilisterial effect of seed essential oil and organic extracts from Zizyphus jujuba. Food Chem Toxicol. 2009;47:2374-80 pubmed publisher
    ..3 microg/ml). Furthermore, the amount of total phenolic compounds was determined. The results indicate that the essential oil and extracts of Z. jujuba could serve as natural antimicrobial and antioxidant agents for the food industry. ..
  61. Elaloui M, Ghazghazi H, Ennajah A, Manaa S, Guezmir W, Karray N, et al. Phenolic profile, antioxidant capacity of five Ziziphus spina-christi (L.) Willd provenances and their allelopathic effects on Trigonella foenum-graecum L. and Lens culinaris L. seeds. Nat Prod Res. 2017;31:1209-1213 pubmed publisher
    ..of this work was to evaluate some secondary metabolites, antioxidant activity of methanolic leaf extracts of five Ziziphus spina-christi provenances (INRGREF, Tozeur, Degueche, Nafta and Kebelli) and their allelopathic effects on ..
  62. Wang Y, Yu T, Li Y, Cai D, Liu X, Lu H, et al. Postharvest biocontrol of Alternaria alternata in Chinese winter jujube by Rhodosporidium paludigenum. J Appl Microbiol. 2009;107:1492-8 pubmed publisher
    ..Rhodosporidium paludigenum can be used as a nonchemical agent in postharvest biological control of Chinese winter jujube. ..
  63. Adzu B, Amos S, Amizan M, Gamaniel K. Evaluation of the antidiarrhoeal effects of Zizyphus spina-christi stem bark in rats. Acta Trop. 2003;87:245-50 pubmed
    ..It is suggested that the extract may contain biologically active components that may be useful against diarrhoea, thereby justifying its use in ethnomedical practice as an antidiarrhoeal agent. ..
  64. Tripathi G, Kumari R, Sharma B. Mesofaunal biodiversity and its importance in Thar desert. J Environ Biol. 2007;28:503-15 pubmed
    ..The present study suggests that the plantation may be done for improvement of physicochemical and biological health of soil on a sustainable basis in desert. ..
  65. Wang Q, Lai T, Qin G, Tian S. Response of jujube fruits to exogenous oxalic acid treatment based on proteomic analysis. Plant Cell Physiol. 2009;50:230-42 pubmed publisher
    ..These results indicated that OA treatment might affect ethanol and ethylene metabolism, resulting in delaying senescence, and increase resistance of jujube fruits against fungal pathogens. ..
  66. Li L, Meng Y, Cao Q, Yang Y, Wang F, Jia H, et al. Type 1 Metallothionein (ZjMT) Is Responsible for Heavy Metal Tolerance in Ziziphus jujuba. Biochemistry (Mosc). 2016;81:565-73 pubmed publisher
    ..a. metallothionein type 1 protein (ZjMT), was isolated from the cDNA library of Ziziphus jujuba...
  67. Boakye Gyasi E, Henneh I, Abotsi W, Ameyaw E, Woode E. Hydro-ethanolic leaf extract of Ziziphus abyssinica Hochst Ex A. Rich (Rhamnaceae) exhibits anti-nociceptive effects in murine models. BMC Complement Altern Med. 2017;17:231 pubmed publisher
    ..Various parts of Ziziphus abyssinica have been used in folk medicine in several African countries as painkillers...
  68. Shahat A, Mahmoud E, Al Mishari A, Alsaid M. ANTIMICROBIAL ACTIVITIES OF SOME SAUDI ARABIAN HERBAL PLANTS. Afr J Tradit Complement Altern Med. 2017;14:161-165 pubmed publisher
    ..extracts of Echium arabicum (SY-176), Rhantarium epapposum (SY-Rumex vesicarus (SY-181), Ziziphus nummularia (SY-188), Caylusea hexagyna (SY-197) and Artemisia monosperma (SY-198) have anti-..
  69. Huang W, Wang Y, Jiang X, Sun Y, Zhao Z, Li S. Protective Effect of Flavonoids from Ziziphus jujuba cv. Jinsixiaozao against Acetaminophen-Induced Liver Injury by Inhibiting Oxidative Stress and Inflammation in Mice. Molecules. 2017;22: pubmed publisher
    ..to investigate the chemical composition, antioxidant activities and hepatoprotective effect of flavonoids from Ziziphus jujuba cv. Jinsixiaozao (ZJF)...
  70. Nisar M, Kaleem W, Khan I, Adhikari A, Khan N, Shah M, et al. Molecular simulations probing Kushecarpin A as a new lipoxygenase inhibitor. Fitoterapia. 2011;82:1008-11 pubmed publisher
    ..oxyphylla Edgew. In vitro and in vivo anti-inflammatory inflammatory activities were found in good agreement with the folk medicinal use of Z. oxyphylla Edgew in inflammatory disorders. ..
  71. Pandey M, Singh A, Singh V, Pandey V. Cyclopeptide alkaloids from Zizyphus sativa bark. Nat Prod Res. 2008;22:219-21 pubmed publisher
    ..A new cyclopeptide alkaloid, sativanine-M (1), together with known alkaloid nummularine-P have been isolated from the stem bark of Zizyphus sativa and identified by spectral analysis. ..
  72. Wang B, Liu H, Zheng J, Fan M, Cao W. Distribution of phenolic acids in different tissues of jujube and their antioxidant activity. J Agric Food Chem. 2011;59:1288-92 pubmed publisher
    ..Our results show that most phenolic compounds with antioxidant activity in different tissues of jujube are present as the glycosided and insoluble-bound forms. ..
  73. Guo S, Duan J, Qian D, Tang Y, Qian Y, Wu D, et al. Rapid determination of amino acids in fruits of Ziziphus jujuba by hydrophilic interaction ultra-high-performance liquid chromatography coupled with triple-quadrupole mass spectrometry. J Agric Food Chem. 2013;61:2709-19 pubmed publisher
    ..Then the method was applied for the analysis of the free amino acids in 46 batches of Ziziphus jujuba fruits which comprised 39 cultivars from 26 cultivation regions...
  74. Sabzghabaee A, Khayam I, Kelishadi R, Ghannadi A, Soltani R, Badri S, et al. Effect of Zizyphus jujuba fruits on dyslipidemia in obese adolescents: a triple-masked randomized controlled clinical trial. Med Arch. 2013;67:156-9 pubmed
    This study aimed to assess the effects of Ziziphus jujuba (ZJ) fruit on controlling dyslipidemia in obese adolescents...
  75. Ebrahimi S, Mollaei H, Hoshyar R. Ziziphus Jujube: a review study of its anticancer effects in various tumor models invitro and invivo. Cell Mol Biol (Noisy-le-grand). 2017;63:122-127 pubmed publisher
    ..b>Ziziphus jujube is one of these plants whose pharmaceutical effects have been studied for a long time...
  76. Nesseem D, Michel C, Sleem A, El Alfy T. Formulation and evaluation of antihyperglycemic leaf extracts of Zizyphus spina-christi (L.) Willd. Pharmazie. 2009;64:104-9 pubmed
    ..01) on acute and long-term administration and highest saponin release. This formula (Sc) contained poly-oxyethylene (20) cetyl ether (BC-20TX), PEG 400, PEG 6000, purified water, meglyol 810, ascorbic acid and 200 mg of extract (c). ..
  77. Shen X, Tang Y, Yang R, Yu L, Fang T, Duan J. The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. J Ethnopharmacol. 2009;122:555-60 pubmed publisher
    ..The study was aimed to investigate the protective effect against hepatic injury induced by CCl(4) for the ethanolic extract of FZJ...
  78. Saif M, Lansigan F, Ruta S, Lamb L, Mezes M, Elligers K, et al. Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies. Phytomedicine. 2010;17:161-9 pubmed publisher
    ..We conducted a Phase I study using PHY906 in combination with capecitabine in patients with advanced pancreatic and gastrointestinal malignancies to determine the maximum tolerated dose (MTD) of capecitabine in combination with PHY906...
  79. Panchal J, Aery N. Remediation potential of certain wild and native species for manganese and iron contaminated waste. J Environ Sci Eng. 2009;51:7-12 pubmed
    ..Only few of the plants survived and showed a tendency to establish and stabilize the waste. In 10% soil + 2 NPK amended waste, Ziziphus mauritiana showed good growth and resulted in an increase of 1966.66% after a period of six months.
  80. Liu C, Li Y, Zhong Y, Huang X, Zheng X, Li N, et al. An LC-MS/MS method for determination of jujuboside A in rat plasma and its application to pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;899:21-6 pubmed publisher
    ..3%. The analyte was stable under various conditions (at room temperature, during freeze-thaw, in the autosampler and under deep-freeze conditions). The developed method was successfully applied to the pharmacokinetic study in rats. ..
  81. Bora D, Deka B, Sen A. Host plant selection by larvae of the muga silk moth, Antheraea assamensis, and the role of the antenna and maxillary palp. J Insect Sci. 2013;13:52 pubmed publisher
    ..Kostermans (Laurales: Lauraceae) and Litsea polyantha Juss, over the non-hosts, Litsea grandifolia Teschner and Ziziphus jujuba Miller (Rosales: Rhamnaceae). Both were competent in rejecting the non-hosts, L. grandifolia and Z. jujuba...
  82. Du L, Gao Q, Ji X, Ma Y, Xu F, Wang M. Comparison of flavonoids, phenolic acids, and antioxidant activity of explosion-puffed and sun-dried jujubes (Ziziphus jujuba Mill.). J Agric Food Chem. 2013;61:11840-7 pubmed publisher
    ..The glycosided and insoluble-bound phenolic acid fractions for each sample represented the highest TPC and the strongest antioxidant activity. The results indicated explosion puffing was a good choice for jujube processing. ..
  83. Lee S, Park J, Lee Y, Lee C, Min B, Kim J, et al. Anti-complementary activity of triterpenoides from fruits of Zizyphus jujuba. Biol Pharm Bull. 2004;27:1883-6 pubmed
    ..This suggests that the oleanane-structure plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes. ..
  84. Peng Y, Peng F, Zhou P, Zhang X. [Absorption and utilization of different applied nitrogen forms by winter jujube]. Ying Yong Sheng Tai Xue Bao. 2007;18:1265-9 pubmed
    ..Compared with urea N, amino acid N could significantly increase the number of colored fruits and their colored area, as well as the content of fruit soluble solid matter. ..
  85. Niu C, Wu C, Sheng Y, Zhang J. Identification and characterization of flavonoids from semen zizyphi spinosae by high-performance liquid chromatography/linear ion trap FTICR hybrid mass spectrometry. J Asian Nat Prod Res. 2010;12:300-12 pubmed publisher
    ..The method was useful for separation and identification of the flavonoid components from SZS and could be applied to other complex samples, especially for minor constituents. ..
  86. Niu C, Zhang J. Quantitative analysis and chromatographic fingerprinting of the semen zizyphi spinosae by ultra-high-performance liquid chromatography coupled with diode-array detector. J Sep Sci. 2011;34:2989-96 pubmed publisher
    ..These results demonstrated that the method was very suitable in the analysis and quality control of SZS. ..
  87. Gao M, Xie L, Wang Y, Chen J, Xu J, Zhang X, et al. Paenibacillus beijingensis sp. nov., a novel nitrogen-fixing species isolated from jujube garden soil. Antonie Van Leeuwenhoek. 2012;102:689-94 pubmed publisher
    ..nov. is proposed. The type strain is 7188(T) (=ACCC 03082(T) = DSM 24997(T)). ..
  88. Kim H, Lee H, Jung I, Jeon S, Zhang J, Kwon Y, et al. The memory ameliorating effects of DHP1402, an herbal mixture, on cholinergic blockade-induced cognitive dysfunction in mice. J Ethnopharmacol. 2018;211:38-46 pubmed publisher
    The seeds of Ziziphus jujuba var. spinosa (Bunge) Hu ex H.F Chow (Rhamnaceae) and the roots of Codonopsis lanceolata (Siedbold & Zucc.) Benth. & Hook. f ex Trautv...
  89. Sangare M, Fernandez Rivera S, Hiernaux P, Pandey V. The effect of supplementation with fresh browse of Ziziphus mauritiana or Combretum aculeatum on feed intake, nitrogen utilization and growth of grazing range sheep. Trop Anim Health Prod. 2003;35:465-76 pubmed
    The influence of 0, 60 or 120 min access to a grove of either Ziziphus mauritiana (Ziziphus) or Combretum aculeatum (Combretum) on forage intake and on the digestibility, growth and excretion of nutrients was determined using 40 Oudah ..
  90. Lee S, Min B, Lee C, Kim K, Kho Y. Cytotoxic triterpenoids from the fruits of Zizyphus jujuba. Planta Med. 2003;69:1051-4 pubmed
    ..These results suggest that the coumaroyl moiety at the C-3 position of the lupane-type triterpene may play an important role in enhancing cytotoxic activity. ..
  91. Huang X, Kojima Yuasa A, Xu S, Kennedy D, Hasuma T, Matsui Yuasa I. Combination of Zizyphus jujuba and green tea extracts exerts excellent cytotoxic activity in HepG2 cells via reducing the expression of APRIL. Am J Chin Med. 2009;37:169-79 pubmed
    ..We speculate that the CHCl(3)-F and GTE mixture might provide a lead to a new drug design to treat hepatocellular carcinoma in the future. ..
  92. Aiassa V, Baronetti J, Paez P, Barnes A, Albrecht C, Pellarin G, et al. Increased advanced oxidation of protein products and enhanced total antioxidant capacity in plasma by action of toxins of Escherichia coli STEC. Toxicol In Vitro. 2011;25:426-31 pubmed publisher
    ..The application of natural antioxidants was sufficient to reduce in vitro the oxidative stress provoked by both toxins in blood...