karwinskia

Summary

Summary: A plant genus of the family RHAMNACEAE that contains tullidinol (toxin T-544) and peroxisomicine (toxin T-514). It is sometimes called buckthorn but should not be confused with other plants called that.

Top Publications

  1. Carcaño Díaz K, Garcia Garcia A, Segoviano Ramirez J, Rodriguez Rocha H, Loera Arias M, Garcia Juarez J. Damage to pancreatic acinar cells and preservation of islets of Langerhans in a rat model of acute pancreatitis induced by Karwinskia humboldtiana (buckthorn). Histol Histopathol. 2016;31:1001-10 pubmed publisher
    b>Karwinskia humboldtiana (Kh) is a poisonous plant that grows in some regions of the American continent. Consuming large amounts of Kh fruit results in acute intoxication leading to respiratory failure, culminating in death within days...
  2. Garza Ocañas L, Zanatta Calderón M, Acosta D, Torres Alanis O, Piñeyro Lopez A. Production of reactive oxygen species by toxin T-514 of genus Karwinskia in vitro. Toxicol In Vitro. 2003;17:19-25 pubmed
    In the present study we have analyzed the production of reactive oxygen species by toxin T-514 of the genus Karwinskia in vitro (primary liver cell cultures and microsomes), as well as their possible role in its cytotoxicity...
  3. Gómez Silva M, Garza Ocañas L, Waksman N, Rivas V, Piñeyro Lopez A. In vitro metabolism and toxicity assessment of toxin T-514 (Peroxisomicine A1) of Karwinskia humboldtiana in microsomes and primary cultured hepatocytes. Toxicol In Vitro. 2005;19:47-53 pubmed
    T-514 (Peroxisomicine A(1)) from Karwinskia humboldtiana is a dimeric hydroxyanthracenone with a highly selective cytotoxic effect on tumor cells...
  4. Becerra Verdin E, Bermúdez Barba M, Salazar Leal M, Ancer Rodriguez J, Romero Diaz V, Soto Domínguez A, et al. Karwinskia humboldtiana (buckthorn) fruit causes central nervous system damage during chronic intoxication in the rat. Toxicon. 2009;53:645-51 pubmed publisher
    b>Karwinskia humboldtiana fruit (Kh) causes a neurological disorder 3-4 weeks after ingestion, characterized by flaccid, symmetrical, ascending paralysis, similar to the Guillain-Barre syndrome...
  5. Díaz Pérez R, Castillo González J, Carcaño Díaz K, García Juárez J, Salazar Leal M, Muñoz Maldonado G, et al. Histopathological alterations in the striatum caused by Karwinskia humboldtiana (Buckthorn) fruit in an experimental model of peripheral neuropathy. Histol Histopathol. 2016;31:393-402 pubmed publisher
    The accidental ingestion of Karwinskia humboldtiana (Kh) fruit in humans and animals causes chronic or acute intoxication. Acute poisoning induces respiratory failure that progresses rapidly to death...
  6. Jaramillo Juárez F, Rodríguez Vázquez M, Muñoz Martínez J, Quezada Tristán T, Posadas del rio F, Llamas Viramontes J, et al. The ATP levels in kidneys and blood are mainly decreased by acute ingestion of tullidora (Karwinskia humboldtiana). Toxicon. 2005;46:99-103 pubmed
    Our previous acute toxicity studies with Karwinskia humboldtiana (Kh) in rats showed renal hemodynamic changes with a marked increase in the fractional excretion of sodium and morphological damage...
  7. Salazar R, Rivas V, Gonzalez G, Waksman N. Antimicrobial activity of coupled hydroxyanthracenones isolated from plants of the genus Karwinskia. Fitoterapia. 2006;77:398-400 pubmed
    The in vitro activity of some isolated hydroxyanthracenones belonging to the genus Karwinskia against four bacteria, six filamentous fungi and four yeast are reported...
  8. Salazar Leal M, Flores M, Sepulveda Saavedra J, Romero Diaz V, Becerra Verdin E, Tamez Rodriguez V, et al. An experimental model of peripheral neuropathy induced in rats by Karwinskia humboldtiana (buckthorn) fruit. J Peripher Nerv Syst. 2006;11:253-61 pubmed
    Intoxication by Karwinskia humboldtiana (buckthorn) fruit presents a neurological picture similar to that of Guillain-Barré syndrome...
  9. Ocampo Roosens L, Ontiveros Nevares P, Fernández Lucio O. Intoxication with buckthorn (Karwinskia humboldtiana): report of three siblings. Pediatr Dev Pathol. 2007;10:66-8 pubmed
    ..The ingestion of the green or ripe fruit of the Karwinskia humboldtiana (buckthorn), a bush known in Mexico as coyotillo or tullidora, causes a flaccid, symmetric, ..