rhodiola

Summary

Summary: A plant genus of the family CRASSULACEAE. Members contain rhodioloside. This roseroot is unrelated to the familiar rose (ROSA). Some species in this genus are called stonecrop which is also a common name for SEDUM.

Top Publications

  1. Ali Z, Fronczek F, Khan I. Phenylalkanoids and monoterpene analogues from the roots of Rhodiola rosea. Planta Med. 2008;74:178-81 pubmed publisher
    Roots extract of Rhodiola rosea L. is the source of important commercial preparations widely used throughout Europe, Asia, and the USA...
  2. Mattioli L, Perfumi M. Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats. J Psychopharmacol. 2007;21:742-50 pubmed
    b>Rhodiola rosea L. is one of the most popular adaptogen and anti-stress plants in European and Asiatic traditional medicine...
  3. Walker T, Robergs R. Does Rhodiola rosea possess ergogenic properties?. Int J Sport Nutr Exerc Metab. 2006;16:305-15 pubmed
    b>Rhodiola rosea is an herb purported to possess adaptogenic and ergogenic properties and has recently been the subject of increased interest The purpose of this article was to review and summarize recent investigations of the potential ..
  4. Gupta V, Lahiri S, Sultana S, Kumar R. Mechanism of action of Rhodiola imbricata Edgew during exposure to cold, hypoxia and restraint (C-H-R) stress induced hypothermia and post stress recovery in rats. Food Chem Toxicol. 2009;47:1239-45 pubmed publisher
    Mechanism of rhodiola root extract adaptogenic activity was studied in rats...
  5. Gupta V, Lahiri S, Sultana S, Tulsawani R, Kumar R. Anti-oxidative effect of Rhodiola imbricata root extract in rats during cold, hypoxia and restraint (C-H-R) exposure and post-stress recovery. Food Chem Toxicol. 2010;48:1019-25 pubmed publisher
    Anti-oxidative potential of Rhodiola imbricata root aqueous extract was examined in rats, administered orally at a dose of 100 mg/kg both in single and multiple doses, 30 min prior to cold (5 degrees C)-hypoxia (428 mmHg)-restraint (C-H-R)..
  6. Tu Y, Roberts L, Shetty K, Schneider S. Rhodiola crenulata induces death and inhibits growth of breast cancer cell lines. J Med Food. 2008;11:413-23 pubmed publisher
    ..Phenolic phytochemicals from Rhodiola crenulata has such potential...
  7. Zuo G, Li Z, Chen L, Xu X. Activity of compounds from Chinese herbal medicine Rhodiola kirilowii (Regel) Maxim against HCV NS3 serine protease. Antiviral Res. 2007;76:86-92 pubmed
    ..fractionation and isolation were performed on a crude ethanol extract from rhizomes of the Chinese medicinal herb Rhodiola kirilowii (Regel) Maxim using column chromatography (CC) techniques and in vitro inhibitory activity against HCV ..
  8. Huang S, Lee F, Kuo T, Yang J, Chien C. Attenuation of long-term Rhodiola rosea supplementation on exhaustive swimming-evoked oxidative stress in the rat. Chin J Physiol. 2009;52:316-24 pubmed
    b>Rhodiola rosea improves exercise endurance and fatigue. We hypothesized that ingredients in Rhodiola rosea may increase antioxidant capability against swimming induced oxidative stress...
  9. Zhang J, Ma L, Yu H, Zhang H, Wang H, Qin Y, et al. A tyrosine decarboxylase catalyzes the initial reaction of the salidroside biosynthesis pathway in Rhodiola sachalinensis. Plant Cell Rep. 2011;30:1443-53 pubmed publisher
    Salidroside, the 8-O-?-D-glucoside of tyrosol, is the main bioactive component of Rhodiola species and is found mainly in the plant roots...

More Information

Publications113 found, 100 shown here

  1. Zhao Y, Qi L, Wang W, Saxena P, Liu C. Melatonin improves the survival of cryopreserved callus of Rhodiola crenulata. J Pineal Res. 2011;50:83-8 pubmed publisher
    ..melatonin in stress protection during the process of cryopreservation using callus of an endangered plant species Rhodiola crenulata...
  2. Cifani C, Micioni Di B M, Vitale G, Ruggieri V, Ciccocioppo R, Massi M. Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating. Physiol Behav. 2010;101:555-62 pubmed publisher
    Stress is a key determinant of binge eating (BE). Since Rhodiola rosea is known to modulate stress responses, its effect in a model of BE was investigated...
  3. Jeong H, Ryu Y, Park S, Kim J, Kwon H, Kim J, et al. Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg Med Chem. 2009;17:6816-23 pubmed publisher
    Five flavonols (3, 5, and 9-11) were isolated from Rhodiola rosea, and compared with commercially available flavonoids (1, 2, 4, 6-8, and 12-14) to facilitate analysis of their structure-activity relationship (SAR)...
  4. Mook Jung I, Kim H, Fan W, Tezuka Y, Kadota S, Nishijo H, et al. Neuroprotective effects of constituents of the oriental crude drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis. Biol Pharm Bull. 2002;25:1101-4 pubmed
    We tested the constituents of two Rhodiola plants, Rhodiola sacra S. H. Fu and R. sachalinensis A. BOR, and an Oriental crude drug, Tokaku-joki-to, for their neuroprotective effects...
  5. Mishra K, Padwad Y, Dutta A, Ganju L, Sairam M, Banerjee P, et al. Aqueous extract of Rhodiola imbricata rhizome inhibits proliferation of an erythroleukemic cell line K-562 by inducing apoptosis and cell cycle arrest at G2/M phase. Immunobiology. 2008;213:125-31 pubmed publisher
    b>Rhodiola imbricata is a medicinal plant having immunostimulating properties. The anti-proliferative effects of Rhodiola aqueous extract (RAE), were studied in human erythroleukemic cell line K-562 using MTT cell proliferation assay...
  6. Sun L, Isaak C, Zhou Y, Petkau J, O K, Liu Y, et al. Salidroside and tyrosol from Rhodiola protect H9c2 cells from ischemia/reperfusion-induced apoptosis. Life Sci. 2012;91:151-8 pubmed publisher
    ..Ischemia-reperfusion injury can lead to apoptotic death of heart cells and subsequently heart failure. Rhodiola is an herbal medicine with two main bioactive compounds--salidroside (SAL) and tyrosol (TYR)...
  7. Mannucci C, Navarra M, Calzavara E, Caputi A, Calapai G. Serotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in rats. Phytomedicine. 2012;19:1117-24 pubmed publisher
    b>Rhodiola rosea has been used for centuries in the traditional medicine to stimulate nervous system, to enhance physical and mental performance and to treat fatigue...
  8. Hou Y, Lou A. Phylogeographical patterns of an alpine plant, Rhodiola dumulosa (Crassulaceae), inferred from chloroplast DNA sequences. J Hered. 2014;105:101-10 pubmed publisher
    The phylogeographical patterns of Rhodiola dumulosa, an alpine plant species restrictedly growing in the crevices of rock piles, were investigated based on 4 fragments of the chloroplast genome. To cover the full distribution of R...
  9. Tolonen A, Hohtola A, Jalonen J. Comparison of electrospray ionization and atmospheric pressure chemical ionization techniques in the analysis of the main constituents from Rhodiola rosea extracts by liquid chromatography/mass spectrometry. J Mass Spectrom. 2003;38:845-53 pubmed
    b>Rhodiola rosea L. (Golden Root) has been used for a long time as an adaptogen in Chinese traditional medicine and is reported to have many pharmacological properties...
  10. Zhou X, Wu Y, Wang X, Liu B, Xu H. Salidroside production by hairy roots of Rhodiola sachalinensis obtained after transformation with Agrobacterium rhizogenes. Biol Pharm Bull. 2007;30:439-42 pubmed
    ..Salidroside has been identified as the major compounds from the roots of Rhodiola sachalinensis A. BOR...
  11. Mattioli L, Funari C, Perfumi M. Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats. J Psychopharmacol. 2009;23:130-42 pubmed publisher
    b>Rhodiola rosea L. is one of the most popular adaptogen and an antistress plant in European and Asiatic traditional medicine. Our previous studies have confirmed the adaptogenic and antistress properties of a single administration of R...
  12. Schriner S, Avanesian A, Liu Y, Luesch H, Jafari M. Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radic Biol Med. 2009;47:577-84 pubmed publisher
    b>Rhodiola rosea root has been long used in traditional medical systems in Europe and Asia as an adaptogen to increase an organism's resistance to physical stress...
  13. Hou Y, Lou A. Population genetic diversity and structure of a naturally isolated plant species, Rhodiola dumulosa (Crassulaceae). PLoS ONE. 2011;6:e24497 pubmed publisher
    b>Rhodiola dumulosa (Crassulaceae) is a perennial diploid species found in high-montane areas. It is distributed in fragmented populations across northern, central and northwestern China...
  14. Chan S. Panax ginseng, Rhodiola rosea and Schisandra chinensis. Int J Food Sci Nutr. 2012;63 Suppl 1:75-81 pubmed publisher
    Panax ginseng (Ginseng), Rhodiola rosea (Hong Jing Tian) and Schisandra chinensis (Wu Wei Zi) are well-known herbs in traditional Chinese medicine (TCM). Recently, there have been a number of studies on these three herbs...
  15. Nakamura S, Li X, Matsuda H, Ninomiya K, Morikawa T, Yamaguti K, et al. Bioactive constituents from Chinese natural medicines. XXVI. Chemical structures and hepatoprotective effects of constituents from roots of Rhodiola sachalinensis. Chem Pharm Bull (Tokyo). 2007;55:1505-11 pubmed
    The methanolic extract from the roots of Rhodiola sachalinensis was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes...
  16. Panossian A, Nikoyan N, Ohanyan N, Hovhannisyan A, Abrahamyan H, Gabrielyan E, et al. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine. 2008;15:84-91 pubmed
    The antidepressant-like activity of an extract of the roots of Rhodiola rosea (RR), its combination with piperine containing extract (RPE), pure substances isolated from Rhodiola, such as rhodioloside, rosavin, rosin, rosarin, tyrosol, ..
  17. Lee F, Kuo T, Liou S, Chien C. Chronic Rhodiola rosea extract supplementation enforces exhaustive swimming tolerance. Am J Chin Med. 2009;37:557-72 pubmed
    We explored the effects and mechanisms of Rhodiola rosea extract supplementation on swimming-induced fatigue in rats...
  18. Cheng Y, Chen L, Lee W, Chen M, Jung Lin H, Cheng J. Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats. J Ethnopharmacol. 2012;144:234-9 pubmed publisher
    b>Rhodiola rosea (also known as golden root or roseroot) is a perennial plant of the Crassulaceae family that grows in the Arctic and in the mountainous regions of Europe, Asia, and North America...
  19. Abidov M, Grachev S, Seifulla R, Ziegenfuss T. Extract of Rhodiola rosea radix reduces the level of C-reactive protein and creatinine kinase in the blood. Bull Exp Biol Med. 2004;138:63-4 pubmed
    The effects of extracts of Rhodiola rosea radix on blood levels of inflammatory C-reactive protein and creatinine kinase were studied in healthy untrained volunteers before and after exhausting exercise...
  20. Ming D, Hillhouse B, Guns E, Eberding A, Xie S, Vimalanathan S, et al. Bioactive compounds from Rhodiola rosea (Crassulaceae). Phytother Res. 2005;19:740-3 pubmed
    The methanol extract of the underground part of Rhodiola rosea was found to show inhibitory activity against Staphylococcus aureus. Bioactivity-guided fractionation of a 95% ethanol extract from the stems of R...
  21. Skarpanska Stejnborn A, Pilaczynska Szczesniak L, Basta P, Deskur Smielecka E. The influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowers. Int J Sport Nutr Exerc Metab. 2009;19:186-99 pubmed
    The aim of this study was to investigate the effect of Rhodiola rosea supplementation on the balance of oxidants and antioxidants in the serum and erythrocytes of competitive rowers...
  22. Zhong H, Xin H, Wu L, Zhu Y. Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway. J Pharmacol Sci. 2010;114:399-408 pubmed
    In the present study, we investigated cardioprotective effects of salidroside, isolated from Rhodiola rosea L, on oxygen-glucose deprivation (OGD)-induced cardiomyocyte death and ischemic injury evoked by acute myocardial infarction (AMI) ..
  23. Ma L, Liu B, Gao D, Pang X, Lu S, Yu H, et al. Molecular cloning and overexpression of a novel UDP-glucosyltransferase elevating salidroside levels in Rhodiola sachalinensis. Plant Cell Rep. 2007;26:989-99 pubmed
    Salidroside is a novel effective adaptogenic drug extracted from the medicinal plant Rhodiola sachalinensis A. Bor...
  24. Chen Q, Zeng Y, Qu Z, Tang J, Qin Y, Chung P, et al. The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Phytomedicine. 2009;16:830-8 pubmed publisher
    The purpose of this study was to investigate the effects of Rhodiola rosea extract and depression on the serotonin (5-HT) level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats induced by Chronic Mild ..
  25. Kucinskaite A, Briedis V, Savickas A. [Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine]. Medicina (Kaunas). 2004;40:614-9 pubmed
    The paper presents a review of the scientific publications on Rhodiola rosea L. known for its adaptogenic characteristics...
  26. Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull Exp Biol Med. 2003;136:585-7 pubmed
    We studied the effects of oral treatment with extracts from Rhodiola rosea (50 mg/kg) and Rhodiola crenulata (50 mg/kg) roots on the duration of exhaustive swimming and ATP content in mitochondria of skeletal muscles in rats...
  27. Mattioli L, Perfumi M. Effects of a Rhodiola rosea L. extract on acquisition and expression of morphine tolerance and dependence in mice. J Psychopharmacol. 2011;25:411-20 pubmed publisher
    This study investigated the effect of Rhodiola rosea L. extract on acquisition and expression of morphine tolerance and dependence in mice...
  28. Goel H, Bala M, Prasad J, Singh S, Agrawala P, Swahney R. Radioprotection by Rhodiola imbricata in mice against whole-body lethal irradiation. J Med Food. 2006;9:154-60 pubmed
    b>Rhodiola imbricata, an Indian medicinal plant, was investigated for protection against whole-body lethal gamma irradiation (10 Gy)-induced mortality in Swiss albino strain "A" mice...
  29. Mishra K, Padwad Y, Jain M, Karan D, Ganju L, Sawhney R. Aqueous extract of Rhodiola imbricata rhizome stimulates proinflammatory mediators via phosphorylated IkappaB and transcription factor nuclear factor-kappaB. Immunopharmacol Immunotoxicol. 2006;28:201-12 pubmed
    ..We have evaluated the immunomodulatory activity of aqueous extract of Rhodiola rhizome in human peripheral blood mononuclear cells (PBMCs) and mouse macrophage cell line RAW 264.7...
  30. Nakamura S, Li X, Matsuda H, Yoshikawa M. Bioactive constituents from Chinese natural medicines. XXVIII. Chemical structures of acyclic alcohol glycosides from the roots of Rhodiola crenulata. Chem Pharm Bull (Tokyo). 2008;56:536-40 pubmed
    Five new glycosides, creosides I, II, III, IV, and V, were isolated from the methanolic extract of the roots of Rhodiola crenulata, together with 21 known compounds...
  31. Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010;17:481-93 pubmed publisher
    ..information related to chemical composition, pharmacological activity, traditional and official use of Rhodiola rosea L. in medicine...
  32. Kanupriya -, Prasad D, Sai Ram M, Kumar R, Sawhney R, Sharma S, et al. Cytoprotective and antioxidant activity of Rhodiola imbricata against tert-butyl hydroperoxide induced oxidative injury in U-937 human macrophages. Mol Cell Biochem. 2005;275:1-6 pubmed
    The present study reports cytoprotective and antioxidant activity of aqueous and alcoholic extracts of Rhodiola imbricata rhizome on tert-butyl hydroperoxide (tert-BHP) induced cytotoxicity in U-937 human macrophages...
  33. Wiedenfeld H, Dumaa M, Malinowski M, Furmanowa M, Narantuya S. Phytochemical and analytical studies of extracts from Rhodiola rosea and Rhodiola quadrifida. Pharmazie. 2007;62:308-11 pubmed
    Column chromatography of hydrophilic extracts from Rhodiola rosea and Rodiola quadrifida led to the isolation of cinnamic alcohol, chlorogenic acid, rhodiooctanoside, rosiridin, rosavin and the phenolic compounds salidroside, rhodiolin ..
  34. Jafari M, Felgner J, Bussel I, Hutchili T, Khodayari B, Rose M, et al. Rhodiola: a promising anti-aging Chinese herb. Rejuvenation Res. 2007;10:587-602 pubmed
    Using the fruit fly, Drosophila melanogaster, we investigated the effects of Rhodiola on life-span. Rhodiola is a plant root used in traditional Chinese medicine that may increase an organism's resistance to stress...
  35. Qu Z, Zhou Y, Zeng Y, Li Y, Chung P. Pretreatment with Rhodiola rosea extract reduces cognitive impairment induced by intracerebroventricular streptozotocin in rats: implication of anti-oxidative and neuroprotective effects. Biomed Environ Sci. 2009;22:318-26 pubmed publisher
    To investigate the pretreatment effects of Rhodiola rosea (R. rosea) extract on cognitive dysfunction, oxidative stress in hippocampus and hippocampal neuron injury in a rat model of Alzheimer's disease (AD)...
  36. De Bock K, Eijnde B, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. 2004;14:298-307 pubmed
    The purpose of this study was to investigate the effect of acute and 4-week Rhodiola rosea intake on physical capacity, muscle strength, speed of limb movement, reaction time, and attention...
  37. Kucinskaite A, Pobłocka Olech L, Krauze Baranowska M, Sznitowska M, Savickas A, Briedis V. Evaluation of biologically active compounds in roots and rhizomes of Rhodiola rosea L. cultivated in Lithuania. Medicina (Kaunas). 2007;43:487-94 pubmed
    Salidroside and rosavins (rosavin, rosarin, and rosin), biologically active compounds of Rhodiola rosea L...
  38. Qu Z, Zhou Y, Zeng Y, Lin Y, Li Y, Zhong Z, et al. Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat. PLoS ONE. 2012;7:e29641 pubmed publisher
    Previously we have demonstrated that a Rhodiola crenulata extract (RCE), containing a potent antioxidant salidroside, promotes neurogenesis in the hippocampus of depressive rats...
  39. Qian E, Ge D, Kong S. Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. J Nat Prod. 2012;75:531-7 pubmed publisher
    b>Rhodiola rosea is a commonly used folk medicine for the treatment of high altitude sickness, mountain malhypoxia, and anoxia...
  40. Ishaque S, Shamseer L, Bukutu C, Vohra S. Rhodiola rosea for physical and mental fatigue: a systematic review. BMC Complement Altern Med. 2012;12:70 pubmed publisher
    b>Rhodiola rosea (R. rosea) is grown at high altitudes and northern latitudes...
  41. Lan X, Chang K, Zeng L, Liu X, Qiu F, Zheng W, et al. Engineering salidroside biosynthetic pathway in hairy root cultures of Rhodiola crenulata based on metabolic characterization of tyrosine decarboxylase. PLoS ONE. 2013;8:e75459 pubmed publisher
    ..Metabolic characterization of tyrosine decarboxylase gene from Rhodiola crenulata (RcTYDC) revealed that it played an important role in salidroside biosynthesis...
  42. Sheng C, Hu T, Bi H, Yuan Y, Jiang Y. [Effects of plant growth substances on induction and culture of callus from Rhodiola quadrifida]. Zhongguo Zhong Yao Za Zhi. 2005;30:1237-40 pubmed
    To investigate the effect of plant growth substances on induction and culture of callus from Rhodiola quadrifida and also to analyze salidroside contents in the callus...
  43. Olsson E, von Scheele B, Panossian A. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009;75:105-12 pubmed publisher
    The aim of the study was to assess the efficacy of the standardised extract SHR-5 of roots of Rhodiola Rosea L. in the treatment of individuals suffering from stress-related fatigue...
  44. Mishra K, Ganju L, Singh S. Anti-cellular and immunomodulatory potential of aqueous extract of Rhodiola imbricata rhizome. Immunopharmacol Immunotoxicol. 2012;34:513-8 pubmed publisher
    In the present study, we have evaluated the anti-cellular and immunomodulatory potential of aqueous extract of Rhodiola imbricata rhizome (RAE)...
  45. De Sanctis R, De Bellis R, Scesa C, Mancini U, Cucchiarini L, Dachà M. In vitro protective effect of Rhodiola rosea extract against hypochlorous acid-induced oxidative damage in human erythrocytes. Biofactors. 2004;20:147-59 pubmed
    b>Rhodiola rosea L. (Crassulaceae) is a plant living at high altitudes in Europe and Asia...
  46. Park S, Kim D, Park S, Shin J, Youn S, Park K. Inhibitory effect of p-coumaric acid by Rhodiola sachalinensis on melanin synthesis in B16F10 cells. Pharmazie. 2008;63:290-5 pubmed
    b>Rhodiola has been widely used in traditional Asian medicine. In this study, we tested the hypopigmentation effects of R. sachalinensis and its active compounds including catechin, chlorogenic acid, p-coumaric acid, and p-tyrosol...
  47. Qin Y, Zeng Y, Zhou C, Li Y, Zhong Z. [Effects of Rhodiola rosea on level of 5-hydroxytryptamine, cell proliferation and differentiation, and number of neuron in cerebral hippocampus of rats with depression induced by chronic mild stress]. Zhongguo Zhong Yao Za Zhi. 2008;33:2842-6 pubmed
    To explore the effects of Rhodiola rosea on the level of 5-hydroxytryptamine (5-HT), cell proliferation and differentiation, and number of neuron in cerebral hippocampus of rats with depression induced by chronic mild stress.
  48. György Z, Jaakola L, Neubauer P, Hohtola A. Isolation and genotype-dependent, organ-specific expression analysis of a Rhodiola rosea cDNA encoding tyrosine decarboxylase. J Plant Physiol. 2009;166:1581-6 pubmed publisher
    ..The difference in the expression intensity suggests a decisive role for this enzyme in the salidroside biosynthesis...
  49. Calcabrini C, De Bellis R, Mancini U, Cucchiarini L, Potenza L, De Sanctis R, et al. Rhodiola rosea ability to enrich cellular antioxidant defences of cultured human keratinocytes. Arch Dermatol Res. 2010;302:191-200 pubmed publisher
    ..In this work it was paid attention to the extract of Rhodiola rosea L...
  50. Liu Z, Li X, Simoneau A, Jafari M, Zi X. Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Mol Carcinog. 2012;51:257-67 pubmed publisher
    ..b>Rhodiola rosea, growing in high altitude or cold regions of the world, has been reported to have anti-aging effects in ..
  51. Wing S, Askew E, Luetkemeier M, Ryujin D, Kamimori G, Grissom C. Lack of effect of Rhodiola or oxygenated water supplementation on hypoxemia and oxidative stress. Wilderness Environ Med. 2003;14:9-16 pubmed
    ..This study investigated the effects of 2 potentially "oxygen promoting" dietary supplements on hypoxia and oxidative stress at a simulated altitude of 4600 m...
  52. Yousef G, Grace M, Cheng D, Belolipov I, Raskin I, Lila M. Comparative phytochemical characterization of three Rhodiola species. Phytochemistry. 2006;67:2380-91 pubmed
    In comparison to the well-recognized adaptogenic herb Rhodiola rosea, phytochemical constituents of two other Rhodiola species (R. heterodonta and R. semenovii) were elucidated and characterized...
  53. Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmstrom C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry. 2007;61:343-8 pubmed
    The objective of this study was to assess the efficacy and safety of standardized extract SHR-5 of rhizomes of Rhodiola rosea L. in patients suffering from a current episode of mild/moderate depression...
  54. Mishra K, Chanda S, Shukla K, Ganju L. Adjuvant effect of aqueous extract of Rhodiola imbricata rhizome on the immune responses to tetanus toxoid and ovalbumin in rats. Immunopharmacol Immunotoxicol. 2010;32:141-6 pubmed publisher
    In the present study we have evaluated the immunopotentiating activity of Rhodiola aqueous extract (RAE) in rats. The efficacy of RAE was determined by using strong antigen tetanus toxoid (TT) and weak antigen Ovalbumin (OVA)...
  55. Hung S, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011;18:235-44 pubmed publisher
    To critically assess the current evidence from randomized clinical trials (RCTs) for or against the effectiveness or efficacy of Rhodiola rosea.
  56. Guan S, Xiong Y, Song B, Song Y, Wang D, Chu X, et al. Protective effects of salidroside from Rhodiola rosea on LPS-induced acute lung injury in mice. Immunopharmacol Immunotoxicol. 2012;34:667-72 pubmed publisher
    Salidroside is a major component extracted from Rhodiola rosea. In this study, we investigated protective effects of salidroside on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice...
  57. Colson S, Wyatt F, Johnston D, Autrey L, FitzGerald Y, Earnest C. Cordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturation. J Strength Cond Res. 2005;19:358-63 pubmed
    Cordyceps sinensis (Cs) and Rhodiola rosea (Rr) are herbs used in traditional Chinese medicine to treat a multitude of ailments as well as to enhance performance...
  58. Wang H, Ding Y, Zhou J, Sun X, Wang S. The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3. Phytomedicine. 2009;16:146-55 pubmed publisher
    The aim of this study was to investigate the antiviral effects of salidroside, a major component of Rhodiola rosea L. First, the antiviral effects of salidroside against coxsackievirus B3 (CVB3) were determined in vitro and in vivo...
  59. Zhang Z, Tong Y, Zou J, Chen P, Yu D. Dietary supplement with a combination of Rhodiola crenulata and Ginkgo biloba enhances the endurance performance in healthy volunteers. Chin J Integr Med. 2009;15:177-83 pubmed publisher
    To determine whether the ingestion of a herbal supplement called Rhodiola-Gingko Capsule (RGC) would enhance the endurance performance of healthy volunteers and change relevant hormones in a favorable manner.
  60. Ioset K, Nyberg N, van Diermen D, Malnoe P, Hostettmann K, Shikov A, et al. Metabolic profiling of Rhodiola rosea rhizomes by ¹H NMR spectroscopy. Phytochem Anal. 2011;22:158-65 pubmed publisher
    b>Rhodiola rosea is a broadly used medicinal plant with largely unexplored natural variability in secondary metabolite levels.
  61. Qian E, Ge D, Kong S. Salidroside promotes erythropoiesis and protects erythroblasts against oxidative stress by up-regulating glutathione peroxidase and thioredoxin. J Ethnopharmacol. 2011;133:308-14 pubmed publisher
    b>Rhodiola rosea is commonly used in China and Tibet folk medicine for the treatment of high altitude sickness, anoxia and mountain malhypoxia.
  62. Bayliak M, Lushchak V. The golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiae. Phytomedicine. 2011;18:1262-8 pubmed publisher
    ..cerevisiae cells, what sensitizes yeast cells to oxidative stress at exponential phase, but induces adaptation in stationary phase cells demonstrating the positive effect on yeast survival without activation of major antioxidant enzymes...
  63. Peschel W, Prieto J, Karkour C, Williamson E. Effect of provenance, plant part and processing on extract profiles from cultivated European Rhodiola rosea L. for medicinal use. Phytochemistry. 2013;86:92-102 pubmed publisher
    The demand for plant material of Rhodiola rosea L. (Crassulaceae) for medicinal use has increased recently, amid concerns about its quality and sustainability...
  64. Kwon Y, Jang H, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr. 2006;15:425-32 pubmed
    In the current study, we investigated 2 species of the genus Rhodiola for the inhibition of alpha-amylase,alpha-glucosidase and angiotensin converting enzyme (ACE) inhibitory activity...
  65. Perfumi M, Mattioli L. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother Res. 2007;21:37-43 pubmed
    b>Rhodiola rosea L...
  66. Li T, Zhang H. Application of microscopy in authentication of traditional Tibetan medicinal plants of five Rhodiola (Crassulaceae) alpine species by comparative anatomy and micromorphology. Microsc Res Tech. 2008;71:448-58 pubmed publisher
    A comparative analysis was undertaken to conduct an anatomical and micromorphological study of five species of Rhodiola-R. kirilowii, R. yunnanensis, R. crenulata, R. fastigata, and R...
  67. Skopńska Rózewska E, Wojcik R, Siwicki A, Sommer E, Wasiutynski A, Furmanowa M, et al. The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats. Pol J Vet Sci. 2008;11:105-11 pubmed
    b>Rhodiola quadrifida (Rq) roots and rhizomes are traditionally used in Asia as a tonic, adaptogen, antidepressant and anti-inflammatory drug...
  68. Bawa A, Khanum F. Anti-inflammatory activity of Rhodiola rosea--"a second-generation adaptogen". Phytother Res. 2009;23:1099-102 pubmed publisher
    b>Rhodiola rosea (golden root), a unique phytoadaptogen grown in high-altitude regions has gained attention for its various therapeutic properties...
  69. Mishra K, Ganju L, Chanda S, Karan D, Sawhney R. Aqueous extract of Rhodiola imbricata rhizome stimulates Toll-like receptor 4, granzyme-B and Th1 cytokines in vitro. Immunobiology. 2009;214:27-31 pubmed publisher
    b>Rhodiola imbricata is a medicinal plant, native to mountainous regions of Asia, parts of Europe, and the Arctic. Traditionally it is recommended to help combat fatigue and restore energy...
  70. Schriner S, Abrahamyan A, Avanessian A, Bussel I, Maler S, Gazarian M, et al. Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radic Res. 2009;43:836-43 pubmed publisher
    The root extract from Rhodiola rosea has been reported to have numerous health benefits in human and animal studies. Its molecular mechanism is currently unknown; however, it has been suggested to act as an antioxidant...
  71. Gao D, Li Q, Liu Z, Feng J, Li J, Han Z, et al. Antidiabetic potential of Rhodiola sachalinensis root extract in streptozotocin-induced diabetic rats. Methods Find Exp Clin Pharmacol. 2009;31:375-81 pubmed publisher
    In this study, we examined the antidiabetic effect and probable mechanisms of Rhodiola sachalinensis root extract (RS)...
  72. Wojcik R, Siwicki A, Skopinska Rozewska E, Wasiutynski A, Sommer E, Furmanowa M. The effect of Chinese medicinal herb Rhodiola kirilowii extracts on cellular immunity in mice and rats. Pol J Vet Sci. 2009;12:399-405 pubmed
    b>Rhodiola kirilowii (RK) roots and rhizomes are traditionally used in China as a tonic, adaptogen, antimicrobial and anti-inflammatory drug...
  73. Lee O, Kwon Y, Apostolidis E, Shetty K, Kim Y. Rhodiola-induced inhibition of adipogenesis involves antioxidant enzyme response associated with pentose phosphate pathway. Phytother Res. 2011;25:106-15 pubmed publisher
    The aim of this study was to investigate whether Rhodiola crenulata extract and tyrosol, a major bioactive phenolic compound present in Rhodiola, change the activities of endogenous antioxidant enzyme response (AER) and energy pathways ..
  74. Edwards D, Heufelder A, Zimmermann A. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study. Phytother Res. 2012;26:1220-5 pubmed publisher
    The trial was conducted to investigate the therapeutic effects and safety of a 4?week treatment with Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms...
  75. Tolonen A, Pakonen M, Hohtola A, Jalonen J. Phenylpropanoid glycosides from Rhodiola rosea. Chem Pharm Bull (Tokyo). 2003;51:467-70 pubmed
    b>Rhodiola rosea L. (Golden Root) has been used for a long time as an adaptogen in Chinese traditional medicine and is reported to have many pharmacological properties...
  76. Shevtsov V, Zholus B, Shervarly V, Vol skij V, Korovin Y, Khristich M, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003;10:95-105 pubmed
    ..with an extra non-treatment group was performed to measure the effect of a single dose of standardized SHR-5 Rhodiola rosea extract on capacity for mental work against a background of fatigue and stress...
  77. Arora R, Chawla R, Sagar R, Prasad J, Singh S, Kumar R, et al. Evaluation of radioprotective activities Rhodiola imbricata Edgew--a high altitude plant. Mol Cell Biochem. 2005;273:209-23 pubmed
    The present study reports the radioprotective properties of a hydro-alcoholic rhizome extract of Rhodiola imbricata (code named REC-7004), a plant native to the high-altitude Himalayas...
  78. Battistelli M, De Sanctis R, De Bellis R, Cucchiarini L, Dacha M, Gobbi P. Rhodiola rosea as antioxidant in red blood cells: ultrastructural and hemolytic behaviour. Eur J Histochem. 2005;49:243-54 pubmed
    b>Rhodiola rosea L. (Crassulaceae) is a plant that lives at high altitude in Europe and Asia, widely used for its high capacity to increase the organism resistance to different stress conditions...
  79. Gupta A, Kumar R, Upadhyay N, Pal K, Kumar R, Sawhney R. Effects of Rhodiola imbricata on dermal wound healing. Planta Med. 2007;73:774-7 pubmed
    b>Rhodiola imbricata (Crassulaceae) is a perennial herb growing at high-altitude (4000 - 5000 m) in the western Himalayas. The present study was aimed at investigating the healing efficacy of R...
  80. Fintelmann V, Gruenwald J. Efficacy and tolerability of a Rhodiola rosea extract in adults with physical and cognitive deficiencies. Adv Ther. 2007;24:929-39 pubmed
    During a 12-wk drug monitoring study, the efficacy and safety of a Rhodiola rosea extract given in combination with vitamins and minerals (vigodana(R)) were tested in 120 adults (83 women and 37 men, ages 50-89 y) with physical and ..
  81. Gupta V, Saggu S, Tulsawani R, Sawhney R, Kumar R. A dose dependent adaptogenic and safety evaluation of Rhodiola imbricata Edgew, a high altitude rhizome. Food Chem Toxicol. 2008;46:1645-52 pubmed publisher
    To examine the dose dependent adaptogenic activity aqueous extract of Rhodiola imbricata root was orally administered in rats at different doses, 30 min prior to cold (5 degrees C)-hypoxia (428 mm Hg)-restraint (C-H-R) exposure...
  82. Wiegant F, Surinova S, Ytsma E, Langelaar Makkinje M, Wikman G, Post J. Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology. 2009;10:27-42 pubmed publisher
    Extracts of plant adaptogens such as Eleutherococcus senticosus (or Acanthopanax senticosus) and Rhodiola rosea can increase stress resistance in several model systems...
  83. Skopinska Rozewska E, Malinowski M, Wasiutynski A, Sommer E, Furmanowa M, Mazurkiewicz M, et al. The influence of Rhodiola quadrifida 50% hydro-alcoholic extract and salidroside on tumor-induced angiogenesis in mice. Pol J Vet Sci. 2008;11:97-104 pubmed
    The genus Rhodiola (Crassulaceae) consists of more than 100 species. They grow mainly in Tibet, China and Mongolia and are traditionally used as tonic, adaptogen, antidepressant and anti-inflammatory drugs...
  84. Shen W, Fan W, Shi H. [Effects of rhodiola on expression of vascular endothelial cell growth factor and angiogenesis in aortic atherosclerotic plaque of rabbits]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008;28:1022-5 pubmed
    To investigate the effects of rhodiola on expression of vascular endothelial cell growth factor (VEGF) and angiogenesis in aortic atherosclerotic plaque of rabbits.
  85. Chen X, Zhang Q, Cheng Q, Ding F. Protective effect of salidroside against H2O2-induced cell apoptosis in primary culture of rat hippocampal neurons. Mol Cell Biochem. 2009;332:85-93 pubmed publisher
    Salidroside, a phenylpropanoid glycoside separated from a medicinal plant Rhodiola rosea, has been documented to have protective effects on neuronal cells in vitro...
  86. Ouyang J, Lou J, Yan C, Ren Z, Qiao H, Hong D. In-vitro promoted differentiation of mesenchymal stem cells towards hepatocytes induced by salidroside. J Pharm Pharmacol. 2010;62:530-8 pubmed publisher
    ..The present study aimed to investigate whether salidroside can induce differentiation of rat mesenchymal stem cells (rMSCs) towards hepatocytes in vitro and the mechanism of hepatic differentiation of rMSCs...
  87. Tayade A, Dhar P, Kumar J, Sharma M, Chauhan R, Chaurasia O, et al. Chemometric profile of root extracts of Rhodiola imbricata Edgew. with hyphenated gas chromatography mass spectrometric technique. PLoS ONE. 2013;8:e52797 pubmed publisher
    b>Rhodiola imbricata Edgew. (Rose root or Arctic root or Golden root or Shrolo), belonging to the family Crassulaceae, is an important food crop and medicinal plant in the Indian trans-Himalayan cold desert...
  88. Cui S, Hu X, Chen X, Hu Z. Determination of p-tyrosol and salidroside in three samples of Rhodiola crenulata and one of Rhodiola kirilowii by capillary zone electrophoresis. Anal Bioanal Chem. 2003;377:370-4 pubmed
    ..CZE) method has been developed for simultaneous assay of two bioactive components (p-tyrosol and salidroside) in Rhodiola crenulata and Rhodiola kirilowii for the first time...
  89. Ruan X, Hou P, Zhou J, Wang Q, Li G. [Analysis on the trace element and amino acid content in xinjiang 6 series Rhodiola L. plant]. Guang Pu Xue Yu Guang Pu Fen Xi. 2001;21:542-4 pubmed
    Trace elements Na, K, Mg, Ca, Mn, Fe, Cu, Zn, Se and 20 kinds of amino acid in Xinjiang 6 series of Rhodiola's root and rootstalk were measured. The result shows that contents of 9 kinds of trace elements in them are different...
  90. Wu S, Zu Y, Wu M. High yield production of salidroside in the suspension culture of Rhodiola sachalinensis. J Biotechnol. 2003;106:33-43 pubmed
    Salidroside has been identified as the most potent ingredient of the Chinese medicine herb, Rhodiola sachalinensis...
  91. Earnest C, Morss G, Wyatt F, Jordan A, Colson S, Church T, et al. Effects of a commercial herbal-based formula on exercise performance in cyclists. Med Sci Sports Exerc. 2004;36:504-9 pubmed
    ..1 (1.8) yr; height: 178.5 (1.8) cm; weight: 77.1 (1.6) kg]...
  92. Zhang L, Yu H, Sun Y, Lin X, Chen B, Tan C, et al. Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Eur J Pharmacol. 2007;564:18-25 pubmed
    ..Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L, shows potent antioxidant property...