juglans

Summary

Summary: A plant genus of the family JUGLANDACEAE that provides the familiar walnut.

Top Publications

  1. Maguire L, O Sullivan S, Galvin K, O Connor T, O Brien N. Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut. Int J Food Sci Nutr. 2004;55:171-8 pubmed
    ..2 to 2071.7 microg/g oil. Campesterol and stigmasterol were also present in significant concentrations. Our data indicate that all five nuts are a good source of monounsaturated fatty acid, tocopherols, squalene and phytosterols...
  2. Fukuda T, Ito H, Yoshida T. Antioxidative polyphenols from walnuts (Juglans regia L.). Phytochemistry. 2003;63:795-801 pubmed
    ..with adenosine, adenine, and 13 known tannins were isolated from the n-BuOH extract of walnuts (the seeds of Juglans regia L.)...
  3. Haque R, Bin Hafeez B, Parvez S, Pandey S, Sayeed I, Ali M, et al. Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamide-induced biochemical toxicity. Hum Exp Toxicol. 2003;22:473-80 pubmed
    Walnut (Juglans regia L.) is extensively used in traditional systems of medicine for treatment of various ailments. It is described as an anticancer, tonic, blood purifier and detoxifier agent...
  4. Li L, Tsao R, Yang R, Liu C, Zhu H, Young J. Polyphenolic profiles and antioxidant activities of heartnut (Juglans ailanthifolia Var. cordiformis) and Persian walnut (Juglans regia L.). J Agric Food Chem. 2006;54:8033-40 pubmed
    The polyphenolic compositions of three heartnut (Juglans ailanthifolia var. cordiformis) varieties (Imshu, Campbell CW1, and Campbell CW3) were examined and compared with those of two Persian walnut (Juglans regia L...
  5. Pereira J, Oliveira I, Sousa A, Valentão P, Andrade P, Ferreira I, et al. Walnut (Juglans regia L.) leaves: phenolic compounds, antibacterial activity and antioxidant potential of different cultivars. Food Chem Toxicol. 2007;45:2287-95 pubmed
    Different cultivars of walnut (Juglans regia L.) leaves (Cv...
  6. Machida K, Matsuoka E, Kasahara T, Kikuchi M. Studies on the constituents of Juglans species. I. Structural determination of (4S)- and (4R)-4-hydroxy-alpha-tetralone derivatives from the fruit of Juglans mandshurica MAXIM. var. sieboldiana MAKINO. Chem Pharm Bull (Tokyo). 2005;53:934-7 pubmed
    ..4S)-4,8-dihydroxy-5-methoxy-alpha-tetralone and (4S)- and (4R)-4-hydroxy-alpha-tetralones, from the fruit of Juglans mandshurica MAXIM. var. sieboldiana MAKINO. Their structures were established on the basis of spectral analysis...
  7. Charrier G, Bonhomme M, Lacointe A, Ameglio T. Are budburst dates, dormancy and cold acclimation in walnut trees (Juglans regia L.) under mainly genotypic or environmental control?. Int J Biometeorol. 2011;55:763-74 pubmed publisher
  8. Xu H, Yu X, Qu S, Sui D. Juglone, isolated from Juglans mandshurica Maxim, induces apoptosis via down-regulation of AR expression in human prostate cancer LNCaP cells. Bioorg Med Chem Lett. 2013;23:3631-4 pubmed publisher
    Juglone is a natural compound which has been isolated from Juglans mandshurica Maxim. Recent studies have shown that juglone had various pharmacological effects such as anti-viral, anti-bacterial and anti-cancer...
  9. Ahn C, Song C, Kim W, Kim Y. Effects of Juglans sinensis Dode extract and antioxidant on mercury chloride-induced acute renal failure in rabbits. J Ethnopharmacol. 2002;82:45-9 pubmed
    This study was undertaken to determine if Juglans sinensis Dode, an oriental medicinal herb, extract (JSE) and antioxidant exert beneficial effect against mercury-induced acute renal failure in rabbits...

More Information

Publications77

  1. Hoban S, Borkowski D, Brosi S, McCleary T, Thompson L, McLachlan J, et al. Range-wide distribution of genetic diversity in the North American tree Juglans cinerea: a product of range shifts, not ecological marginality or recent population decline. Mol Ecol. 2010;19:4876-91 pubmed publisher
    ..as the clear determinant of genetic diversity, differentiation and bottlenecks in 29 populations of butternut, Juglans cinerea L., a North American outcrossing forest tree...
  2. Canales A, Benedi J, Nus M, Librelotto J, Sánchez Montero J, Sanchez Muniz F. Effect of walnut-enriched restructured meat in the antioxidant status of overweight/obese senior subjects with at least one extra CHD-risk factor. J Am Coll Nutr. 2007;26:225-32 pubmed
    ..Despite its high energy content, it also appears adequate for overweight and obese people because did not exert negative effect upon body weight. ..
  3. Xu H, Yu X, Qu S, Zhang R, Qu X, Chen Y, et al. Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway. Eur J Pharmacol. 2010;645:14-22 pubmed publisher
    ..Juglone, a major chemical constituent of Juglans mandshurica Maxim, possesses several bioactivities including anti-tumor...
  4. Amaral J, Cunha S, Alves M, Pereira J, Seabra R, Oliveira B. Triacylglycerol composition of walnut (Juglans regia L.) cultivars: characterization by HPLC-ELSD and chemometrics. J Agric Food Chem. 2004;52:7964-9 pubmed
    A total of 26 walnut (Juglans regia L...
  5. Hardman W, Ion G, Akinsete J, Witte T. Dietary walnut suppressed mammary gland tumorigenesis in the C(3)1 TAg mouse. Nutr Cancer. 2011;63:960-70 pubmed publisher
    ..The results of this study indicate that walnut consumption could contribute to a healthy diet to reduce risk for breast cancer. ..
  6. Damasceno N, Pérez Heras A, Serra M, Cofan M, Sala Vila A, Salas Salvado J, et al. Crossover study of diets enriched with virgin olive oil, walnuts or almonds. Effects on lipids and other cardiovascular risk markers. Nutr Metab Cardiovasc Dis. 2011;21 Suppl 1:S14-20 pubmed publisher
    ..We designed a study in hypercholesterolemic patients to assess the effects on serum lipids and other intermediate markers of cardiovascular risk of replacing 40% of the fat in the background diet with VOO, walnuts or almonds...
  7. Chauhan N, Wang K, Wegiel J, Malik M. Walnut extract inhibits the fibrillization of amyloid beta-protein, and also defibrillizes its preformed fibrils. Curr Alzheimer Res. 2004;1:183-8 pubmed
    ..It is proposed that polyphenolic compounds (such as flavonoids) present in walnuts may be responsible for its anti-amyloidogenic activity. ..
  8. Morgan J, Horton K, Reese D, Carey C, Walker K, Capuzzi D. Effects of walnut consumption as part of a low-fat, low-cholesterol diet on serum cardiovascular risk factors. Int J Vitam Nutr Res. 2002;72:341-7 pubmed
    ..However, these changes may not explain all of the beneficial effects that walnut consumption has on cardiovascular disease. ..
  9. Banel D, Hu F. Effects of walnut consumption on blood lipids and other cardiovascular risk factors: a meta-analysis and systematic review. Am J Clin Nutr. 2009;90:56-63 pubmed publisher
    ..Larger and longer-term trials are needed to address the effects of walnut consumption on cardiovascular risk and body weight. ..
  10. Simon J, Tanzman J, Sabate J. Lack of effect of walnuts on serum levels of prostate specific antigen: a brief report. J Am Coll Nutr. 2007;26:317-20 pubmed
    ..06 mug/L, 95% CI [0.81, 1.38]) (P = 0.86) (or a mean proportional decrease in PSA of -1%). Our results suggest that short-term consumption of walnuts is unlikely to affect PSA levels adversely among otherwise normal men. ..
  11. Colaric M, Veberic R, Solar A, Hudina M, Stampar F. Phenolic acids, syringaldehyde, and juglone in fruits of different cultivars of Juglans regia L. J Agric Food Chem. 2005;53:6390-6 pubmed
    ..The ratio between the contents in pellicle and kernel varied by at least 14.8-fold for caffeic acid (cv. Adams) and by up to 752.0-fold for p-coumaric acid (cv. Elit)...
  12. Bai W, Zeng Y, Zhang D. Mating patterns and pollen dispersal in a heterodichogamous tree, Juglans mandshurica (Juglandaceae). New Phytol. 2007;176:699-707 pubmed
    ..Here, mating patterns and pollen dispersal were studied in Juglans mandshurica, a heterodichogamous wind-pollinated species that is widely distributed in northern and north-eastern ..
  13. Tapsell L, Gillen L, Patch C, Batterham M, Owen A, Bare M, et al. Including walnuts in a low-fat/modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes. Diabetes Care. 2004;27:2777-83 pubmed
    ..The aim of this study was to examine the effect of a moderate-fat diet inclusive of walnuts on blood lipid profiles in patients with type 2 diabetes...
  14. Papoutsi Z, Kassi E, Chinou I, Halabalaki M, Skaltsounis L, Moutsatsou P. Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483. Br J Nutr. 2008;99:715-22 pubmed
    ..In the present study, we sought a role of walnuts (Juglans regia L.) in endothelial and bone-cell function...
  15. Spaccarotella K, Kris Etherton P, Stone W, Bagshaw D, Fishell V, West S, et al. The effect of walnut intake on factors related to prostate and vascular health in older men. Nutr J. 2008;7:13 pubmed publisher
    ..Tocopherols may protect against prostate cancer and cardiovascular disease (CVD)...
  16. Ma Y, Njike V, Millet J, Dutta S, Doughty K, Treu J, et al. Effects of walnut consumption on endothelial function in type 2 diabetic subjects: a randomized controlled crossover trial. Diabetes Care. 2010;33:227-32 pubmed publisher
    ..To determine the effects of daily walnut consumption on endothelial function, cardiovascular biomarkers, and anthropometric measures in type 2 diabetic individuals...
  17. McKay D, Chen C, Yeum K, Matthan N, Lichtenstein A, Blumberg J. Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study. Nutr J. 2010;9:21 pubmed publisher
    Compared with other common plant foods, walnuts (Juglans regia) are consistently ranked among the highest in antioxidant capacity...
  18. Bai W, Zeng Y, Liao W, Zhang D. Flowering phenology and wind-pollination efficacy of heterodichogamous Juglans mandshurica (Juglandaceae). Ann Bot. 2006;98:397-402 pubmed
    ..This study aims to quantify the flowering pattern and pollination efficacy in Juglans mandshurica, a wind-pollinated heterodichogamous tree.
  19. Davis P, Valacchi G, Pagnin E, Shao Q, Gross H, Calo L, et al. Walnuts reduce aortic ET-1 mRNA levels in hamsters fed a high-fat, atherogenic diet. J Nutr. 2006;136:428-32 pubmed
    ..Finally, the results indicate that the walnut fat compartment is a likely location for the components responsible for the reduced aortic CE concentration...
  20. Kolařík M, Freeland E, Utley C, Tisserat N. Geosmithia morbida sp. nov., a new phytopathogenic species living in symbiosis with the walnut twig beetle (Pityophthorus juglandis) on Juglans in USA. Mycologia. 2011;103:325-32 pubmed publisher
    Widespread morbidity and mortality of Juglans nigra has occurred in the western USA over the past decade...
  21. Kaur K, Michael H, Arora S, Härkönen P, Kumar S. Studies on correlation of antimutagenic and antiproliferative activities of Juglans regia L. J Environ Pathol Toxicol Oncol. 2003;22:59-67 pubmed
    We investigated the effect of water and acetone extract of Juglans regia L. to evaluate its antimutagenic and antiproliferative activities...
  22. Hardman W, Ion G. Suppression of implanted MDA-MB 231 human breast cancer growth in nude mice by dietary walnut. Nutr Cancer. 2008;60:666-74 pubmed publisher
    ..Tumor cell proliferation was decreased, but apoptosis was not altered due to walnut consumption. Further work is merited to investigate applications to cancer in humans...
  23. Haider S, Batool Z, Tabassum S, Perveen T, Saleem S, Naqvi F, et al. Effects of walnuts (Juglans regia) on learning and memory functions. Plant Foods Hum Nutr. 2011;66:335-40 pubmed publisher
    ..The findings suggest that walnut may exert its hypophagic and nootropic actions via an enhancement of brain 5-HT metabolism...
  24. Pereira J, Oliveira I, Sousa A, Ferreira I, Bento A, Estevinho L. Bioactive properties and chemical composition of six walnut (Juglans regia L.) cultivars. Food Chem Toxicol. 2008;46:2103-11 pubmed publisher
    The chemical composition, antioxidant potential and antimicrobial activity were studied in six walnuts (Juglans regia L.) cultivars (cv. Franquette, Lara, Marbot, Mayette, Mellanaise and Parisienne) produced in Portugal...
  25. Beritognolo I, Magel E, Abdel Latif A, Charpentier J, Jay Allemand C, Breton C. Expression of genes encoding chalcone synthase, flavanone 3-hydroxylase and dihydroflavonol 4-reductase correlates with flavanol accumulation during heartwood formation in Juglans nigra. Tree Physiol. 2002;22:291-300 pubmed
    ..We monitored seasonal changes in flavanol concentration across the stems of 23-year-old Juglans nigra L. trees by sampling growth rings extending from the differentiating xylem to the heartwood...
  26. Orhan I, Süntar I, Akkol E. In vitro neuroprotective effects of the leaf and fruit extracts of Juglans regia L. (walnut) through enzymes linked to Alzheimer's disease and antioxidant activity. Int J Food Sci Nutr. 2011;62:781-6 pubmed publisher
    Several extracts of the leaves and fruits of Juglans regia L. were assessed for their neuroprotective effects through antioxidant and anti-cholinesterase methods...
  27. Amarowicz R, Dykes G, Pegg R. Antibacterial activity of tannin constituents from Phaseolus vulgaris, Fagoypyrum esculentum, Corylus avellana and Juglans nigra. Fitoterapia. 2008;79:217-9 pubmed publisher
    ..extract preparations of phenolic compounds from Phaseolus vulgaris, Fagoypyrum esculentum, Corylus avellana and Juglans nigra. Wide variations in antibacterial activities ranging from MICs of 62.5 to 500 microg/ml were apparent...
  28. Davis L, Stonehouse W, Loots D, Mukuddem Petersen J, van der Westhuizen F, Hanekom S, et al. The effects of high walnut and cashew nut diets on the antioxidant status of subjects with metabolic syndrome. Eur J Nutr. 2007;46:155-64 pubmed
    ..It is hypothesized that the inclusion of nuts in the diet will improve the antioxidant status of subjects with metabolic syndrome who may be vulnerable to impaired antioxidant status...
  29. Fukuda T, Ito H, Yoshida T. Effect of the walnut polyphenol fraction on oxidative stress in type 2 diabetes mice. Biofactors. 2004;21:251-3 pubmed
    ..These results imply that walnut polyphenols have both in vitro and in vivo antioxidant effects...
  30. Griel A, Kris Etherton P. Tree nuts and the lipid profile: a review of clinical studies. Br J Nutr. 2006;96 Suppl 2:S68-78 pubmed
  31. Pellegrini N, Serafini M, Salvatore S, Del Rio D, Bianchi M, Brighenti F. Total antioxidant capacity of spices, dried fruits, nuts, pulses, cereals and sweets consumed in Italy assessed by three different in vitro assays. Mol Nutr Food Res. 2006;50:1030-8 pubmed
    ..The complete TAC database could be utilized to properly investigate the role of dietary antioxidants in disease prevention...
  32. Cortés B, Núñez I, Cofan M, Gilabert R, Pérez Heras A, Casals E, et al. Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function. J Am Coll Cardiol. 2006;48:1666-71 pubmed
  33. Amaral J, Casal S, Pereira J, Seabra R, Oliveira B. Determination of sterol and fatty acid compositions, oxidative stability, and nutritional value of six walnut (Juglans regia L.) cultivars grown in Portugal. J Agric Food Chem. 2003;51:7698-702 pubmed
    Six cultivars (Franquette, Marbot, Mayette, Mellanaise, Lara, and Parisienne) of walnuts (Juglans regia L.) were collected during the 2001 crop, from Bragança, Portugal...
  34. Wu H, Pan A, Yu Z, Qi Q, Lu L, Zhang G, et al. Lifestyle counseling and supplementation with flaxseed or walnuts influence the management of metabolic syndrome. J Nutr. 2010;140:1937-42 pubmed publisher
    ..Flaxseed and walnut supplementation may ameliorate central obesity. Further studies with larger sample sizes and of longer duration are needed to examine the role of these foods in the prevention and management of MetS...
  35. Fitschen P, Rolfhus K, Winfrey M, Allen B, Manzy M, Maher M. Cardiovascular effects of consumption of black versus English walnuts. J Med Food. 2011;14:890-8 pubmed publisher
  36. Mahoney N, Molyneux R. Phytochemical inhibition of aflatoxigenicity in Aspergillus flavus by constituents of walnut (Juglans regia). J Agric Food Chem. 2004;52:1882-9 pubmed
    ..Regulation of gallic acid levels in the hydrolyzable tannins of walnuts by conventional breeding or genetic manipulation has the potential to provide new cultivars with high resistance to aflatoxigenesis...
  37. Olmedilla Alonso B, Granado Lorencio F, Herrero Barbudo C, Blanco Navarro I, Blázquez García S, Pérez Sacristán B. Consumption of restructured meat products with added walnuts has a cholesterol-lowering effect in subjects at high cardiovascular risk: a randomised, crossover, placebo-controlled study. J Am Coll Nutr. 2008;27:342-8 pubmed
    ..Nut consumption, particularly walnut intake, has been inversely related to incident coronary heart disease (CHD) in observational studies and to improved lipid profiles in short-term feeding trials...
  38. Aronis K, Vamvini M, Chamberland J, Sweeney L, Brennan A, Magkos F, et al. Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomi. Metabolism. 2012;61:577-82 pubmed publisher
    ..Four days of walnut consumption (48 g/d) leads to mild increases in apolipoprotein A concentrations, changes that may precede and lead to the beneficial effects of walnuts on lipid profile in obese subjects with the metabolic syndrome...
  39. Oliveira I, Sousa A, Ferreira I, Bento A, Estevinho L, Pereira J. Total phenols, antioxidant potential and antimicrobial activity of walnut (Juglans regia L.) green husks. Food Chem Toxicol. 2008;46:2326-31 pubmed publisher
    The total phenols content and antioxidant and antimicrobial activities were studied in walnut (Juglans regia L.) green husks aqueous extracts of five different cultivars (Franquette, Mayette, Marbot, Mellanaise and Parisienne)...
  40. Davis P, Vasu V, Gohil K, Kim H, Khan I, Cross C, et al. A high-fat diet containing whole walnuts (Juglans regia) reduces tumour size and growth along with plasma insulin-like growth factor 1 in the transgenic adenocarcinoma of the mouse prostate model. Br J Nutr. 2012;108:1764-72 pubmed publisher
    ..Moreover, as the two HF diets had dissimilar effects on prostate tumour growth rate and size, and yet had the same total fat and tocopherol composition and content, this suggests that these are not strongly linked to PCa growth...
  41. Blomhoff R, Carlsen M, Andersen L, Jacobs D. Health benefits of nuts: potential role of antioxidants. Br J Nutr. 2006;96 Suppl 2:S52-60 pubmed
    ..Further studies are needed to clarify whether antioxidants contribute to this apparent beneficial health effect of nuts...
  42. Ito H, Okuda T, Fukuda T, Hatano T, Yoshida T. Two novel dicarboxylic Acid derivatives and a new dimeric hydrolyzable tannin from walnuts. J Agric Food Chem. 2007;55:672-9 pubmed
    ..hydrolyzable tannin, glansrin D (3), were isolated, together with 15 known compounds from walnuts, the seeds of Juglans regia...
  43. Min B, Lee S, Kim J, Lee J, Kim T, Kim D, et al. Anti-complement activity of constituents from the stem-bark of Juglans mandshurica. Biol Pharm Bull. 2003;26:1042-4 pubmed
    Four known flavonoids and two galloyl glucoses isolated from the stem-bark of Juglans mandshurica (Juglandaceae), namely taxifolin (1), afzelin (2), quercitrin (3), myricitrin (4), 1,2,6-trigalloylglucose (5), and 1,2,3,6-..
  44. West S, Krick A, Klein L, Zhao G, Wojtowicz T, McGuiness M, et al. Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function. J Am Coll Nutr. 2010;29:595-603 pubmed
    ..In a previous article, we showed significant reductions in low-density lipoprotein cholesterol and several markers of inflammation with increasing intake of alpha-linolenic acid (ALA) from walnuts and flax...
  45. Hasan T, B L, Shafi G, Al Hazzani A, Alshatwi A. Anti-proliferative effects of organic extracts from root bark of Juglans Regia L. (RBJR) on MDA-MB-231 human breast cancer cells: role of Bcl-2/Bax, caspases and Tp53. Asian Pac J Cancer Prev. 2011;12:525-30 pubmed
    ..The present study was undertaken to investigate the effect of root bark of Juglans regia (RBJR) organic extracts on cell proliferation, and to determine the molecular mechanism of RBJR-induced ..
  46. Yang H, Cho H, Sim S, Chung Y, Kim D, Sung S, et al. Cytotoxic terpenoids from Juglans sinensis leaves and twigs. Bioorg Med Chem Lett. 2012;22:2079-83 pubmed publisher
    ..The cytotoxicity of compounds (1-7) against four cancer cell lines such as B16F10, Hep-2, MCF-7 and U87-MG was evaluated. Compounds 1, 2, 6 and 7 showed potent cytotoxicity against all of four cancer cell lines, respectively...
  47. Qadan F, Thewaini A, Ali D, Afifi R, Elkhawad A, Matalka K. The antimicrobial activities of Psidium guajava and Juglans regia leaf extracts to acne-developing organisms. Am J Chin Med. 2005;33:197-204 pubmed
    This study aims to present the in vitro inhibitory effect of Psidium guajava and Juglans regia leaf extracts on the main developer of acne lesions, Propionibacterium acnes (P...
  48. Mukuddem Petersen J, Stonehouse Oosthuizen W, Jerling J, Hanekom S, White Z. Effects of a high walnut and high cashew nut diet on selected markers of the metabolic syndrome: a controlled feeding trial. Br J Nutr. 2007;97:1144-53 pubmed
    ..Subjects displayed no improvement in the markers of the metabolic syndrome after following a walnut diet or a cashew nut diet compared to a control diet while maintaining body weight...
  49. Bonhomme M, Peuch M, Ameglio T, Rageau R, Guilliot A, Decourteix M, et al. Carbohydrate uptake from xylem vessels and its distribution among stem tissues and buds in walnut (Juglans regia L.). Tree Physiol. 2010;30:89-102 pubmed publisher
    ..use the xylem sap carbohydrates, the fluxes between xylem vessels and parenchyma cells, bark and buds of walnut (Juglans regia cv 'Franquette') were measured during the rest period until bud break...
  50. Brennan A, Sweeney L, Liu X, Mantzoros C. Walnut consumption increases satiation but has no effect on insulin resistance or the metabolic profile over a 4-day period. Obesity (Silver Spring). 2010;18:1176-82 pubmed publisher
    ..Walnut consumption over 4 days increased satiety by day 3. Long-term studies are needed to confirm the physiologic role of walnuts, the duration of time needed for these effects to occur, and to elucidate the underlying mechanisms...
  51. Shimoda H, Tanaka J, Kikuchi M, Fukuda T, Ito H, Hatano T, et al. Walnut polyphenols prevent liver damage induced by carbon tetrachloride and d-galactosamine: hepatoprotective hydrolyzable tannins in the kernel pellicles of walnut. J Agric Food Chem. 2008;56:4444-9 pubmed publisher
    ..Telliamgrandin I especially completely suppressed both CCl 4- and d-GalN-induced cell damage, and thus is likely the principal constituent for the hepatoprotective effect of WP...
  52. Huang Z, Meilan R, Woeste K. A KNAT3-like homeobox gene from Juglans nigra L., JnKNAT3-like, highly expressed during heartwood formation. Plant Cell Rep. 2009;28:1717-24 pubmed publisher
    The value of black walnut (Juglans nigra L.) is affected by the quality and quantity of darkly colored heartwood in its stem...
  53. Sabate J, Cordero MacIntyre Z, Siapco G, Torabian S, Haddad E. Does regular walnut consumption lead to weight gain?. Br J Nutr. 2005;94:859-64 pubmed
    ..Our findings show that regular walnut intake resulted in weight gain much lower than expected and which became non-significant after controlling for differences in energy intake...
  54. Zhang Y, Cui Y, Zhu J, Li H, Mao J, Jin X, et al. The anti-tumor effect and biological activities of the extract JMM6 from the stem-barks of the Chinese Juglans mandshurica Maxim on human hepatoma cell line BEL-7402. Afr J Tradit Complement Altern Med. 2013;10:258-69 pubmed
    b>Juglans mandshurica Maxim is a traditional herbal medicines in China, and its anti-tumor bioactivities are of research interest...
  55. Bhatia K, Rahman S, Ali M, Raisuddin S. In vitro antioxidant activity of Juglans regia L. bark extract and its protective effect on cyclophosphamide-induced urotoxicity in mice. Redox Rep. 2006;11:273-9 pubmed
    Walnut (Juglans regia L.) bark has been claimed to possess anti-inflammatory, blood purifying, anticancer, depurative, diuretic and laxative activities. It contains several therapeutically active constituents, especially polyphenols...
  56. Ross Davis A, Huang Z, McKenna J, Ostry M, Woeste K. Morphological and molecular methods to identify butternut (Juglans cinerea) and butternut hybrids: relevance to butternut conservation. Tree Physiol. 2008;28:1127-33 pubmed
    Butternut (Juglans cinerea L.) is a native, cold-tolerant, hard-mast species formerly valued for its nuts and wood, which is now endangered...
  57. Tapsell L, Batterham M, Teuss G, Tan S, Dalton S, Quick C, et al. Long-term effects of increased dietary polyunsaturated fat from walnuts on metabolic parameters in type II diabetes. Eur J Clin Nutr. 2009;63:1008-15 pubmed publisher
    ..This study assessed the effect of sustained high polyunsaturated fatty acids (PUFA) intake through walnut consumption on metabolic outcomes in type II diabetes...
  58. Gonzalez Sarrias A, Giménez Bastida J, García Conesa M, Gómez Sánchez M, García Talavera N, Gil Izquierdo A, et al. Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice. Mol Nutr Food Res. 2010;54:311-22 pubmed publisher
    ..Our results suggest that urolithin glucuronides and dimethyl ellagic acid may be the molecules responsible for the beneficial effects of PJ against PCa...
  59. Amaral J, Alves M, Seabra R, Oliveira B. Vitamin E composition of walnuts (Juglans regia L.): a 3-year comparative study of different cultivars. J Agric Food Chem. 2005;53:5467-72 pubmed
    The tocopherol and tocotrienol composition of walnuts (Juglans regia L.) was determined for nine cultivars (cvs. Arco, Franquette, Hartley, Lara, Marbot, Mayette, Mellanaise, Parisienne, and Rego)...
  60. Martínez M, Labuckas D, Lamarque A, Maestri D. Walnut (Juglans regia L.): genetic resources, chemistry, by-products. J Sci Food Agric. 2010;90:1959-67 pubmed publisher
    Walnut (Juglans regia L.) is the most widespread tree nut in the world. There is a great diversity of genotypes differing in forestry, productivity, physical and chemical nut traits...
  61. Torabian S, Haddad E, Cordero MacIntyre Z, Tanzman J, Fernandez M, Sabate J. Long-term walnut supplementation without dietary advice induces favorable serum lipid changes in free-living individuals. Eur J Clin Nutr. 2010;64:274-9 pubmed publisher
    ..Walnuts have been shown to reduce serum lipids in short-term well-controlled feeding trials. Little information exists on the effect and sustainability of walnut consumption for longer duration in a free-living situation...
  62. Negi A, Luqman S, Srivastava S, Krishna V, Gupta N, Darokar M. Antiproliferative and antioxidant activities of Juglans regia fruit extracts. Pharm Biol. 2011;49:669-73 pubmed publisher
    Cancer chemopreventive action of walnut [Juglans regia L. (Juglandaceae)] has been explored.
  63. Wallowitz M, Peterson W, Uratsu S, Comstock S, Dandekar A, Teuber S. Jug r 4, a legumin group food allergen from walnut (Juglans regia Cv. Chandler). J Agric Food Chem. 2006;54:8369-75 pubmed
    ..Serum IgE from 21 of 37 (57%) patients bound the rJug r 4 fusion protein. In vitro cross-reactivity was demonstrated with hazelnut, cashew, and peanut protein extracts...
  64. Carvalho M, Ferreira P, Mendes V, Silva R, Pereira J, Jeronimo C, et al. Human cancer cell antiproliferative and antioxidant activities of Juglans regia L. Food Chem Toxicol. 2010;48:441-7 pubmed publisher
    ..phenolic contents and antioxidant properties of methanolic and petroleum ether extracts obtained from walnut (Juglans regia L.) seed, green husk and leaf...
  65. Decourteix M, Alves G, Brunel N, Am glio T, Guillio A, Lemoine R, et al. JrSUT1, a putative xylem sucrose transporter, could mediate sucrose influx into xylem parenchyma cells and be up-regulated by freeze-thaw cycles over the autumn-winter period in walnut tree (Juglans regia L.). Plant Cell Environ. 2006;29:36-47 pubmed
    ..A putative sucrose transporter cDNA (JrSUT1: Juglans regia sucrose transporter 1) was isolated...
  66. Cruz Vega D, Verde Star M, Salinas González N, Rosales Hernández B, Estrada Garcia I, Méndez Aragón P, et al. Antimycobacterial activity of Juglans regia, Juglans mollis, Carya illinoensis and Bocconia frutescens. Phytother Res. 2008;22:557-9 pubmed publisher
    ..Bark and leaf crude extracts of Juglans regia L., Juglans mollis Engelm., Carya illinoensis (Wangenh) K...
  67. Reiter R, Manchester L, Tan D. Melatonin in walnuts: influence on levels of melatonin and total antioxidant capacity of blood. Nutrition. 2005;21:920-4 pubmed
    We investigated whether melatonin is present in walnuts (Juglans regia L.) and, if so, tested whether eating walnuts influences melatonin levels and the total antioxidant status of the blood.
  68. Sordet C, Culerrier R, Granier C, Rance F, Didier A, Barre A, et al. Expression of Jug r 1, the 2S albumin allergen from walnut (Juglans regia), as a correctly folded and functional recombinant protein. Peptides. 2009;30:1213-21 pubmed publisher
    ..Recombinant Jug r 1 could be used for a component-resolved diagnosis of food-allergy...