garcinia mangostana

Summary

Summary: A plant genus of the family CLUSIACEAE. It is the source of the mangosteen fruit.

Top Publications

  1. Suksamrarn S, Suwannapoch N, Phakhodee W, Thanuhiranlert J, Ratananukul P, Chimnoi N, et al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo). 2003;51:857-9 pubmed
    Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential...
  2. Nguyen L, Venkatraman G, Sim K, Harrison L. Xanthones and benzophenones from Garcinia griffithii and Garcinia mangostana. Phytochemistry. 2005;66:1718-23 pubmed
    ..The acetone extract of the heartwood of Garcinia mangostana contained one new diprenylated xanthone (mangoxanthone) and a new benzophenone (3',6-dihydroxy-2,4,4'-..
  3. Jung H, Su B, Keller W, Mehta R, Kinghorn A. Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J Agric Food Chem. 2006;54:2077-82 pubmed
    As part of ongoing research on cancer chemopreventive agents from botanical dietary supplements, Garcinia mangostana L. (commonly known as mangosteen) was selected for detailed study...
  4. Chin Y, Jung H, Chai H, Keller W, Kinghorn A. Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (Mangosteen). Phytochemistry. 2008;69:754-8 pubmed
    Bioactivity-guided fractionation of a dichloromethane-soluble extract of Garcinia mangostana fruits has led to the isolation and identification of five compounds, including two xanthones, 1,2-dihydro-1,8,10-trihydroxy-2-(2-hydroxypropan-..
  5. Ee G, Daud S, Izzaddin S, Rahmani M. Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line. J Asian Nat Prod Res. 2008;10:475-9 pubmed publisher
    ..for natural anti-cancer lead compounds from plants has led us to the discovery that the stem and roots of Garcinia mangostana can be a source of such compounds...
  6. Han A, Kim J, Lantvit D, Kardono L, Riswan S, Chai H, et al. Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen). J Nat Prod. 2009;72:2028-31 pubmed publisher
    Bioassay-guided fractionation of a chloroform-soluble extract of Garcinia mangostana stem bark, using the HT-29 human colon cancer cell line and an enzyme-based ELISA NF-kappaB assay, led to the isolation of a new xanthone, 11-hydroxy-3-..
  7. Bumrungpert A, Kalpravidh R, Chitchumroonchokchai C, Chuang C, West T, Kennedy A, et al. Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes. J Nutr. 2009;139:1185-91 pubmed publisher
    ..Taken together, these data demonstrate that MG attenuates LPS-mediated inflammation and insulin resistance in human adipocytes, possibly by inhibiting the activation of MAPK, NF-kappaB, and AP-1...
  8. Pedraza Chaverri J, Cárdenas Rodríguez N, Orozco Ibarra M, Perez Rojas J. Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol. 2008;46:3227-39 pubmed publisher
    Many tropical plants have interesting biological activities with potential therapeutic applications. Garcinia mangostana Linn. (GML) belongs to the family of Guttiferae and is named "the queen of fruits"...
  9. Devi Sampath P, Vijayaraghavan K. Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxicol. 2007;21:336-9 pubmed
    ..These findings indicate the protective effect of alpha-mangostin on lipid peroxidation and antioxidant tissue defense system during ISO-induced myocardial infarction in rats...

More Information

Publications72

  1. Chomnawang M, Surassmo S, Nukoolkarn V, Gritsanapan W. Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes. Fitoterapia. 2007;78:401-8 pubmed
    ..Antioxidant activity was determined by DPPH scavenging and NBT reduction assay. The result showed that Garcinia mangostana possessed the most significant antioxidant activity and reduced reactive oxygen species production...
  2. Charernsriwilaiwat N, Rojanarata T, Ngawhirunpat T, Sukma M, Opanasopit P. Electrospun chitosan-based nanofiber mats loaded with Garcinia mangostana extracts. Int J Pharm. 2013;452:333-43 pubmed publisher
    ..of this study was to prepare electrospun chitosan-based nanofiber mats and to incorporate the fruit hull of Garcinia mangostana (GM) extracts into the mats...
  3. Kaomongkolgit R, Jamdee K, Chaisomboon N. Antifungal activity of alpha-mangostin against Candida albicans. J Oral Sci. 2009;51:401-6 pubmed
    ..The strong antifungal activity and low toxicity of alpha-mangostin make it a promising agent for treatment of oral candidiasis...
  4. Rassameemasmaung S, Sirikulsathean A, Amornchat C, Hirunrat K, Rojanapanthu P, Gritsanapan W. Effects of herbal mouthwash containing the pericarp extract of Garcinia mangostana L on halitosis, plaque and papillary bleeding index. J Int Acad Periodontol. 2007;9:19-25 pubmed
  5. Kosem N, Ichikawa K, Utsumi H, Moongkarndi P. In vivo toxicity and antitumor activity of mangosteen extract. J Nat Med. 2013;67:255-63 pubmed publisher
    Mangosteen (Garcinia mangostana) has been widely used in the traditional medicine of Thailand to treat various ailments, especially diseases of the digestive system and infections...
  6. Chang H, Huang W, Chen H, Yang L. Apoptotic effects of ?-mangostin from the fruit hull of Garcinia mangostana on human malignant glioma cells. Molecules. 2010;15:8953-66 pubmed publisher
    ..effects of ?-mangostin, a xanthone derivative isolated and purified from the hull of the tropical fruit Garcinia mangostana. The ?-mangostin showed potent antiproliferative activity toward MGs in dose- and time-dependent manners...
  7. Jang H, Kwon O, Oh S, Lee H, Ahn K, Chin Y. Mangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma. Food Chem Toxicol. 2012;50:4042-50 pubmed publisher
    and ?-Mangostin, which are the major xanthones purified from a Mangosteen, Garcinia mangostana Linn., exhibit a wide range of anticancer, antioxidant, and anti-inflammatory activities...
  8. Tewtrakul S, Wattanapiromsakul C, Mahabusarakam W. Effects of compounds from Garcinia mangostana on inflammatory mediators in RAW264.7 macrophage cells. J Ethnopharmacol. 2009;121:379-82 pubmed publisher
    The fruit hull of Garcinia mangostana Linn. has been used in Thai traditional medicine for treatment of abscess and skin infection.
  9. Ramaiya A, Li G, Petiwala S, Johnson J. Single dose oral pharmacokinetic profile of ?-mangostin in mice. Curr Drug Targets. 2012;13:1698-704 pubmed
    The mangosteen fruit (Garcinia mangostana) is a rich source of dietary xanthones with the most prominent being ?-mangostin. Dietary xanthones have been reported to have a variety of health promoting properties...
  10. Ngawhirunpat T, Opanasopi P, Sukma M, Sittisombut C, Kat A, Adachi I. Antioxidant, free radical-scavenging activity and cytotoxicity of different solvent extracts and their phenolic constituents from the fruit hull of mangosteen (Garcinia mangostana). Pharm Biol. 2010;48:55-62 pubmed publisher
    ..and cytotoxicity of three extracts (water, methanol, and hexane) from the fruit hull of mangosteen (Garcinia mangostana Linn...
  11. Balunas M, Su B, Brueggemeier R, Kinghorn A. Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. J Nat Prod. 2008;71:1161-6 pubmed publisher
    Twelve xanthone constituents of the botanical dietary supplement mangosteen (the pericarp of Garcinia mangostana) were screened using a noncellular, enzyme-based microsomal aromatase inhibition assay...
  12. Gutierrez Orozco F, Chitchumroonchokchai C, Lesinski G, Suksamrarn S, Failla M. ?-Mangostin: anti-inflammatory activity and metabolism by human cells. J Agric Food Chem. 2013;61:3891-900 pubmed publisher
    ..The anti-inflammatory activities of xanthones and their metabolites in different tissues merit consideration...
  13. Tangpong J, Miriyala S, Noel T, Sinthupibulyakit C, Jungsuwadee P, St Clair D. Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of Garcinia mangostana. Neuroscience. 2011;175:292-9 pubmed publisher
    ..The present study tested the protective effect of a xanthone derivative of Garcinia Mangostana against Dox-induced neuronal toxicity...
  14. Itoh T, Ohguchi K, Iinuma M, Nozawa Y, Akao Y. Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation. Bioorg Med Chem. 2008;16:4500-8 pubmed publisher
    Mangostin, Garcinia mangostana L. is used as a traditional medicine in southeast Asia for inflammatory and septic ailments...
  15. Chitchumroonchokchai C, Riedl K, Suksumrarn S, Clinton S, Kinghorn A, Failla M. Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults. J Nutr. 2012;142:675-80 pubmed publisher
    ..These results show that xanthones in mangosteen juice are absorbed when ingested along with a high-fat meal, although release of xanthones from pericarp particles during digestion may be limited...
  16. Nakatani K, Nakahata N, Arakawa T, Yasuda H, Ohizumi Y. Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells. Biochem Pharmacol. 2002;63:73-9 pubmed
    The fruit hull of mangosteen, Garcinia mangostana L., has been used for many years as a medicine for treatment of skin infection, wounds, and diarrhea in Southeast Asia...
  17. Jiang H, Quan X, Tian W, Hu J, Wang P, Huang S, et al. Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana. Bioorg Med Chem Lett. 2010;20:6045-7 pubmed publisher
    ..The bioassay-guided chemical investigation of the hulls of Garcinia mangostana led to the isolation of 13 phenolic compounds (1-13) mainly including xanthone and benzophenone, in which ..
  18. Johnson J, Petiwala S, Syed D, Rasmussen J, Adhami V, Siddiqui I, et al. ?-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth. Carcinogenesis. 2012;33:413-9 pubmed publisher
    ..01). The ability of ?-mangostin to inhibit PCa in vitro and in vivo suggests ?-mangostin may be a novel agent for the management of PCa...
  19. Aisha A, Abu Salah K, Ismail Z, Majid A. In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract. BMC Complement Altern Med. 2012;12:104 pubmed
    ..Xanthones are a group of oxygen-containing heterocyclic compounds with remarkable pharmacological effects such as anti-cancer, antioxidant, anti-inflammatory, and antimicrobial activities...
  20. Nabandith V, Suzui M, Morioka T, Kaneshiro T, Kinjo T, Matsumoto K, et al. Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat. Asian Pac J Cancer Prev. 2004;5:433-8 pubmed
    ..study was to examine whether crude alpha-mangostin (a major xanthone derivative in mangosteen pericarp (Garcinia mangostana)) has short-term chemopreventive effects on putative preneoplastic lesions involved in rat colon ..
  21. Tang Y, Li P, Kondo M, Ji H, Kou Y, Ou B. Effect of a mangosteen dietary supplement on human immune function: a randomized, double-blind, placebo-controlled trial. J Med Food. 2009;12:755-63 pubmed publisher
    ..001). The results indicated that the intake of an antioxidant-rich product significantly enhanced immune responses and improved the subject's self-appraisal on his or her overall health status...
  22. Shan T, Ma Q, Guo K, Liu J, Li W, Wang F, et al. Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs. Curr Mol Med. 2011;11:666-77 pubmed
    ..Xanthones, from the pericarp, whole fruit, heartwood, and leaf of mangosteen (Garcinia mangostana Linn...
  23. Li L, Brunner I, Han A, Hamburger M, KINGHORN A, Frye R, et al. Pharmacokinetics of ?-mangostin in rats after intravenous and oral application. Mol Nutr Food Res. 2011;55 Suppl 1:S67-74 pubmed publisher
    The xanthone ?-mangostin is one of the major bioactive secondary metabolites in Garcinia mangostana. Until now, in vivo studies on the absorption, bioavailability, disposition, and metabolism of ?-mangostin are limited.
  24. Sampath P, Vijayaragavan K. Ameliorative prospective of alpha-mangostin, a xanthone derivative from Garcinia mangostana against beta-adrenergic cathecolamine-induced myocardial toxicity and anomalous cardiac TNF-alpha and COX-2 expressions in rats. Exp Toxicol Pathol. 2008;60:357-64 pubmed publisher
    ..Restoration of cellular normalcy accredits the cytoprotective role of alpha-mangostin...
  25. Chen L, Yang L, Wang C. Anti-inflammatory activity of mangostins from Garcinia mangostana. Food Chem Toxicol. 2008;46:688-93 pubmed
    The fruit hull of Garcinia mangostana Linn (Guttiferae) is used as an anti-inflammatory drug in Southeast Asia. Two xanthones, alpha- and gamma-mangostins, were isolated from the fruit hull of G...
  26. Loo A, Huang D. Assay-guided fractionation study of alpha-amylase inhibitors from Garcinia mangostana pericarp. J Agric Food Chem. 2007;55:9805-10 pubmed
    Alpha-amylase inhibitor (alpha-AI) activity of Garcinia mangostana, commonly known as mangosteen, pericarp extracts was studied by assay guided fractionations from lipophilic to hydrophilic using combined solvent extraction and Amberlite ..
  27. Ji X, Avula B, Khan I. Quantitative and qualitative determination of six xanthones in Garcinia mangostana L. by LC-PDA and LC-ESI-MS. J Pharm Biomed Anal. 2007;43:1270-6 pubmed
    ..The developed methods were applied to the determination of six xanthones in Garcinia mangostana products. The satisfactory results showed that the methods are effective for the analysis of real samples.
  28. Nakatani K, Atsumi M, Arakawa T, Oosawa K, Shimura S, Nakahata N, et al. Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant. Biol Pharm Bull. 2002;25:1137-41 pubmed
    The fruit hull of mangosteen, Garcinia mangostana L. has been used as a Thai indigenous medicine for many years. However, its mechanism of action as a medicine has not been elucidated...
  29. Sampath P, Kannan V. Mitigation of mitochondrial dysfunction and regulation of eNOS expression during experimental myocardial necrosis by alpha-mangostin, a xanthonic derivative from Garcinia mangostana. Drug Chem Toxicol. 2009;32:344-52 pubmed publisher
  30. Doi H, Shibata M, Shibata E, Morimoto J, Akao Y, Iinuma M, et al. Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer. Anticancer Res. 2009;29:2485-95 pubmed
  31. Rassameemasmaung S, Sirikulsathean A, Amornchat C, Maungmingsook P, Rojanapanthu P, Gritsanaphan W. Topical application of Garcinia mangostana L. pericarp gel as an adjunct to periodontal treatment. Complement Ther Med. 2008;16:262-7 pubmed
    To evaluate the effects of gel containing Garcinia mangostana L. pericarp extract (GM gel) applied topically as an adjunct to periodontal treatment.
  32. Watanapokasin R, Jarinthanan F, Jerusalmi A, Suksamrarn S, Nakamura Y, Sukseree S, et al. Potential of xanthones from tropical fruit mangosteen as anti-cancer agents: caspase-dependent apoptosis induction in vitro and in mice. Appl Biochem Biotechnol. 2010;162:1080-94 pubmed publisher
    The pericarp of mangosteen (Garcinia mangostana L.) is rich in various xanthones that are known to possess unique biological activities...
  33. Walker E. HPLC analysis of selected xanthones in mangosteen fruit. J Sep Sci. 2007;30:1229-34 pubmed
    ..This analytical method is applied to the analysis of these xanthones in the rind of the mangosteen fruit, Garcinia mangostana.
  34. Sakagami Y, Iinuma M, Piyasena K, Dharmaratne H. Antibacterial activity of alpha-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics. Phytomedicine. 2005;12:203-8 pubmed
    alpha-Mangostin, isolated from the stem bark of Garcinia mangostana L., was found to be active against vancomycin resistant Enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA), with MIC values of 6.25 and 6.25 to 12...
  35. Wang J, Shi Q, Zhang W, Sanderson B. Anti-skin cancer properties of phenolic-rich extract from the pericarp of mangosteen (Garcinia mangostana Linn.). Food Chem Toxicol. 2012;50:3004-13 pubmed publisher
    ..Apoptosis was significantly increased after MPEE treatment of SK-MEL-28 cells. Hence, MPEE showed strong anti-skin cancer effect on these two skin cancer cell lines, with potential as an anti-skin cancer agent...
  36. Bumrungpert A, Kalpravidh R, Chuang C, Overman A, Martinez K, Kennedy A, et al. Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. J Nutr. 2010;140:842-7 pubmed publisher
  37. Shibata M, Iinuma M, Morimoto J, Kurose H, Akamatsu K, Okuno Y, et al. ?-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation. BMC Med. 2011;9:69 pubmed publisher
  38. Quan G, Oh S, Kim J, Lee H, Kinghorn A, Chin Y. Xanthone constituents of the fruits of Garcinia mangostana with anticomplement activity. Phytother Res. 2010;24:1575-7 pubmed publisher
    Phytochemical investigation of a chloroform-soluble fraction of the freeze-dried fruits of Garcinia mangostana (Clusiaceace) with anticomplement activity in the classical pathway led to the identification of five known xanthones...
  39. Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M. Garcinia mangostana L.: a phytochemical and pharmacological review. Phytother Res. 2009;23:1047-65 pubmed publisher
    b>Garcinia mangostana L. (mangosteen, Clusiaceae) has a long history of use as a medical plant, mostly in Southeast Asia. This is a review of the phytochemistry and pharmacology of mangosteen...
  40. Udani J, Singh B, Barrett M, Singh V. Evaluation of Mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study. Nutr J. 2009;8:48 pubmed publisher
    ..The purpose of this study was to evaluate the effect of multiple dosages of a proprietary Mangosteen Juice blend on indicators of inflammation and antioxidant levels in obese patients with elevated C-reactive protein (CRP) levels...
  41. Kondo M, Zhang L, Ji H, Kou Y, Ou B. Bioavailability and antioxidant effects of a xanthone-rich Mangosteen (Garcinia mangostana) product in humans. J Agric Food Chem. 2009;57:8788-92 pubmed publisher
    ..Overall, this study demonstrated the bioavailability of antioxidants from a xanthone-rich mangosteen product and its in vivo antioxidant effects...
  42. Palapol Y, Ketsa S, Lin Wang K, Ferguson I, Allan A. A MYB transcription factor regulates anthocyanin biosynthesis in mangosteen (Garcinia mangostana L.) fruit during ripening. Planta. 2009;229:1323-34 pubmed publisher
    Mangosteen (Garcinia mangostana L.) fruit undergo rapid red colour development, both on the tree and after harvest, resulting in high anthocyanin production in the pericarp...
  43. Weecharangsan W, Opanasopit P, Sukma M, Ngawhirunpat T, Sotanaphun U, Siripong P. Antioxidative and neuroprotective activities of extracts from the fruit hull of mangosteen (Garcinia mangostana Linn.). Med Princ Pract. 2006;15:281-7 pubmed
    The aim of this study was to investigate the antioxidative and neuroprotective activities of various extracts from the fruit hull of mangosteen (Garcinia mangostana Linn., GM).
  44. Fukuda M, Sakashita H, Hayashi H, Shiono J, Miyake G, Komine Y, et al. Synergism between ?-mangostin and TRAIL induces apoptosis in squamous cell carcinoma of the oral cavity through the mitochondrial pathway. Oncol Rep. 2017;38:3439-3446 pubmed publisher
    Mangosteen (Garcinia mangostana) is a tree found in South-East Asia and the pericarp of its fruit has been used in folk medicine for the treatment of many human illnesses...
  45. Teh S, Ahmad R, Wan Abdullah W, Liong M. Enhanced growth of lactobacilli in soymilk upon immobilization on agrowastes. J Food Sci. 2010;75:M155-64 pubmed publisher
    ..the effects of agrowastes from durian (Durio zibethinus), cempedak (Artocarpus champeden), and mangosteen (Garcinia mangostana) as immobilizers for lactobacilli grown in soymilk...
  46. Phuong N, Van Quang N, Mai T, Anh N, Kuhakarn C, Reutrakul V, et al. Antibiofilm activity of α-mangostin extracted from Garcinia mangostana L. against Staphylococcus aureus. Asian Pac J Trop Med. 2017;10:1154-1160 pubmed publisher
    To isolate α-mangostin (AMG) from the peels of mangosteen (Garcinia mangostana L.), grown in Vietnam, and to investigate antibiofilm activity of this compound against three Staphylococcus aureus (S...
  47. Yostawonkul J, Surassmo S, Namdee K, Khongkow M, Boonthum C, Pagseesing S, et al. Nanocarrier-mediated delivery of ?-mangostin for non-surgical castration of male animals. Sci Rep. 2017;7:16234 pubmed publisher
    ..Mangosteen (Garcinia mangostana L) pericarp extract has been shown to exhibit anti-fertility property...
  48. Pan T, Wu D, Cai N, Chen R, Shi X, Li B, et al. Alpha-Mangostin protects rat articular chondrocytes against IL-1?-induced inflammation and slows the progression of osteoarthritis in a rat model. Int Immunopharmacol. 2017;52:34-43 pubmed publisher
    ..Mangostin (?-MG), which can be isolated from the fruit of the tropical evergreen tree Garcinia mangostana-L, is known to have anti-inflammatory properties...
  49. Hsu J, Skover G, Goldman M. Evaluating the efficacy in improving facial photodamage with a mixture of topical antioxidants. J Drugs Dermatol. 2007;6:1141-8 pubmed
    ..9 mm3. The addition of 3 antioxidants, green and white teas, mangosteen, and pomegranate, have an additive effect to enhance the improvement of age-related changes in the skin. ..
  50. Chang H, Yang L. Gamma-mangostin, a micronutrient of mangosteen fruit, induces apoptosis in human colon cancer cells. Molecules. 2012;17:8010-21 pubmed publisher
    ..The treatment of colorectal cancer includes surgery, radiation therapy and chemotherapy. Mangosteen (Garcinia mangostana) is a famous Asian tropical fruit. ?-Mangostin is a xanthone derivative isolated from the fruit hull...
  51. Bhadra B, Begum Z, Shivaji S. Pichia garciniae sp. nov., isolated from a rotten mangosteen fruit (Garcinia mangostana L., Clusiaceae). Int J Syst Evol Microbiol. 2008;58:2665-9 pubmed publisher
    Ascogenous yeasts were isolated from a decaying mangosteen fruit (Garcinia mangostana L., Clusiaceae). Based on colony morphology and RAPD analysis, the strains were grouped into four groups (G-I, G-II, G-III and G-IV)...
  52. Nualkaew N, Morita H, Shimokawa Y, Kinjo K, Kushiro T, De Eknamkul W, et al. Benzophenone synthase from Garcinia mangostana L. pericarps. Phytochemistry. 2012;77:60-9 pubmed publisher
    ..III polyketide synthase (PKS), was cloned and the recombinant protein expressed from the fruit pericarps of Garcinia mangostana L., which contains mainly prenylated xanthones...
  53. Arunrattiyakorn P, Suksamrarn S, Suwannasai N, Kanzaki H. Microbial metabolism of ?-mangostin isolated from Garcinia mangostana L. Phytochemistry. 2011;72:730-4 pubmed publisher
    Mangostin (1), a prenylated xanthone isolated from the fruit hull of Garcinia mangostana L., was individually metabolized by two fungi, Colletotrichum gloeosporioides (EYL131) and Neosartorya spathulata (EYR042), repectively...
  54. Kurose H, Shibata M, Iinuma M, Otsuki Y. Alterations in cell cycle and induction of apoptotic cell death in breast cancer cells treated with ?-mangostin extracted from mangosteen pericarp. J Biomed Biotechnol. 2012;2012:672428 pubmed publisher
    ..In conclusion, ?-mangostin may be useful as a therapeutic agent for breast cancer carrying a p53 mutation and having HER2- and hormone receptor-negative subtypes...
  55. Taher M, Tg Zakaria T, Susanti D, Zakaria Z. Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats. BMC Complement Altern Med. 2016;16:135 pubmed publisher
    Various parts of Garcinia mangostana Linn., including its pericarp, have been traditionally used to treat a variety of ailments...
  56. Zhao Y, Liu J, Lu D, Li P, Zhang L. Two new xanthones from the pericarp of Garcinia mangostana. Nat Prod Res. 2012;26:61-5 pubmed publisher
    ..1,6-dihydroxy-7-methoxy-8-(3-methylbut-3-enyl)-6',6'-dimethyl-4',5'-dihydropyrano[2'3'?:?3,2]xanthone (2), were isolated from the pericarp of Garcinia mangostana. Their structures were elucidated by spectral means (1-D and 2-D NMR, MS).
  57. Wang J, Sanderson B, Zhang W. Significant anti-invasive activities of ?-mangostin from the mangosteen pericarp on two human skin cancer cell lines. Anticancer Res. 2012;32:3805-16 pubmed
    ..This study aimed at investigating the anti-invasive activities of ?-mangostin on human melanoma SK-MEL-28 and squamous cell carcinoma A-431 cell lines...
  58. Buelna Chontal M, Correa F, Hernández Reséndiz S, Zazueta C, Pedraza Chaverri J. Protective effect of ?-mangostin on cardiac reperfusion damage by attenuation of oxidative stress. J Med Food. 2011;14:1370-4 pubmed publisher
    This study was designed to investigate if ?-mangostin (?-M), a xanthone present in the pericarp of Garcinia mangostana L., was able to protect against reperfusion injury in Langendorff-reperfused hearts...
  59. Fu M, Qiu S, Xu Y, Wu J, Chen Y, Yu Y, et al. A new xanthone from the pericarp of Garcinia mangostana. Nat Prod Commun. 2013;8:1733-4 pubmed
    ..1), was isolated from the EtOAc-soluble partition of the ethanol extract of the pericarp of Garcinia mangostana L., along with three known compounds, namely 8-deoxygartanin (2), 1-isomangostin (3), and garcinone C (4)...
  60. Polyorach S, Wanapat M, Cherdthong A, Kang S. Rumen microorganisms, methane production, and microbial protein synthesis affected by mangosteen peel powder supplement in lactating dairy cows. Trop Anim Health Prod. 2016;48:593-601 pubmed publisher
    ..assigned according to a 4 × 4 Latin square design to study the effect of mangosteen (Garcinia mangostana) peel powder (MSP) supplementation on rumen microorganisms, methane production, and microbial protein ..
  61. Ryu H, Cho J, Curtis Long M, Yuk H, Kim Y, Jung S, et al. ?-Glucosidase inhibition and antihyperglycemic activity of prenylated xanthones from Garcinia mangostana. Phytochemistry. 2011;72:2148-54 pubmed publisher
    ..Furthermore, the most active ?-glucosidase inhibitors (6, 9, and 14) were proven to be present in high quantities in the native seedcase by a HPLC chromatogram...
  62. Asfour H. Antimicrobial and quorum sensing inhibitory activities of the pericarp of Garcinia mangostana. Pak J Pharm Sci. 2016;29:1353-7 pubmed
    A prenylated xanthone, ?-mangostin was separated from the alcoholic extract of Garcinia mangostana pericarp. Its structure was established by different spectroscopic analysis...
  63. Zhang C, Bu Q, Zheng Y, Song B, Li W. [Study on ultraviolet-screening effect of extracts from mangosteen (Garcinia mangostana Linn.) pericarp]. Wei Sheng Yan Jiu. 2011;40:505-6 pubmed
    ..To analyze the ultraviolet-screening of the n-butanol extracts of mangosteen pericarp and alpha-mangostin, compare the ultraviolet-screening effect of the extracts with rutin and ultramicro-titanium dioxide (TiO2)...