clusiaceae

Summary

Summary: The mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.

Top Publications

  1. Poumale H, Randrianasolo R, Rakotoarimanga J, Raharisololalao A, Krebs H, Tchouankeu J, et al. Flavonoid glycosides and other constituents of Psorospermum androsaemifolium BAKER (Clusiaceae). Chem Pharm Bull (Tokyo). 2008;56:1428-30 pubmed
    ..The structures of these secondary metabolites were established using detailed spectroscopic analysis and by comparison with published data. Compounds 1, 1a, 1b, 2, 3, 3a and 4 showed weak antifungal and antibacterial activities...
  2. Kuete V, Nguemeving J, Beng V, Azebaze A, Etoa F, Meyer M, et al. Antimicrobial activity of the methanolic extracts and compounds from Vismia laurentii De Wild (Guttiferae). J Ethnopharmacol. 2007;109:372-9 pubmed
    ..These results provide promising baseline information for the potential use of these crude extracts as well as some of the isolated compounds in the treatment of bacterial and fungal infections...
  3. Suffredini I, Paciencia M, Nepomuceno D, Younes R, Varella A. Antibacterial and cytotoxic activity of Brazilian plant extracts--Clusiaceae. Mem Inst Oswaldo Cruz. 2006;101:287-90 pubmed
    Twelve extracts obtained from nine plants belonging to six different genera of Clusiaceae were analyzed against Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus and Enterococcus faecalis)..
  4. Nguemeving J, Azebaze A, Kuete V, Eric Carly N, Beng V, Meyer M, et al. Laurentixanthones A and B, antimicrobial xanthones from Vismia laurentii. Phytochemistry. 2006;67:1341-6 pubmed
    ..The structures of compounds were established by means of spectroscopic methods. Furthermore, the compounds were screened for antimicrobial activities in vitro...
  5. Teh S, Cheng Lian Ee G, Mah S, Lim Y, Rahmani M. Mesua beccariana (Clusiaceae), a source of potential anti-cancer lead compounds in drug discovery. Molecules. 2012;17:10791-800 pubmed publisher
  6. Coqueiro A, Regasini L, Skrzek S, Queiroz M, Silva D, da Silva Bolzani V. Free radical scavenging activity of Kielmeyera variabilis (Clusiaceae). Molecules. 2013;18:2376-85 pubmed publisher
    ..we screened the free radical scavenging activity of two extracts and eight fractions of Kielmeyera variabilis (Clusiaceae) using DPPH· (2,2-diphenyl-1-picrylhydrazyl-hydrate) and ABTS·+ [2,2'-azinobis(3-ethylenebenzothiazoline-6-..
  7. Acuña U, Jancovski N, Kennelly E. Polyisoprenylated benzophenones from Clusiaceae: potential drugs and lead compounds. Curr Top Med Chem. 2009;9:1560-80 pubmed
    ..3.1]-nonane-2,4,9-trione core structure have been isolated from plants in the Clusiaceae family, and their potent biological properties have been the subject of several studies...
  8. Wabo H, Kouam S, Krohn K, Hussain H, Tala M, Tane P, et al. Prenylated anthraquinones and other constituents from the seeds of Vismia laurentii. Chem Pharm Bull (Tokyo). 2007;55:1640-2 pubmed
    ..Compounds 1, 4 and 5 exhibited moderate algicidal activity against Chlorella fusca and 3 showed moderate activity against the gram-positive bacterium Bacillus megaterium...
  9. Lavaud A, Soleti R, Hay A, Richomme P, Guilet D, Andriantsitohaina R. Paradoxical effects of polyphenolic compounds from Clusiaceae on angiogenesis. Biochem Pharmacol. 2012;83:514-23 pubmed publisher
    b>Clusiaceae plants display high contents of xanthones and coumarins, the effects of which on endothelium, more particularly on angiogenesis, have not been assessed yet...

More Information

Publications93

  1. Kouam S, Khan S, Krohn K, Ngadjui B, Kapche D, Yapna D, et al. Alpha-glucosidase inhibitory anthranols, kenganthranols A-C, from the stem bark of Harungana madagascariensis. J Nat Prod. 2006;69:229-33 pubmed
    ..Some isolated compounds (3-5, 7-11) were evaluated for their alpha-glucosidase inhibition activity. Compounds 3, 4, 8, and 11 showed significant activity, whereas compounds 7, 9, and 10 were inactive in this test...
  2. Marti G, Eparvier V, Moretti C, Prado S, Grellier P, Hue N, et al. Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae). Phytochemistry. 2010;71:964-74 pubmed publisher
    ..1 to 10.1 microM. A LC/ESI-MS(n) study performed on polyprenylated benzophenones previously isolated from Moronobea coccinea provided a reliable method for their detection in the extract and structural elucidation...
  3. Budde K, González Martínez S, Hardy O, Heuertz M. The ancient tropical rainforest tree Symphonia globulifera L. f. (Clusiaceae) was not restricted to postulated Pleistocene refugia in Atlantic Equatorial Africa. Heredity (Edinb). 2013;111:66-76 pubmed publisher
    ..f. (Clusiaceae), using plastid DNA sequences (chloroplast DNA [cpDNA], psbA-trnH intergenic spacer) and nuclear microsatellites ..
  4. Tamokou J, Tala M, Wabo H, Kuiate J, Tane P. Antimicrobial activities of methanol extract and compounds from stem bark of Vismia rubescens. J Ethnopharmacol. 2009;124:571-5 pubmed publisher
    ..The plant, Vismia rubescens (Guttiferae) is popularly used in Cameroon and in several parts of Africa as febrifugal and for the treatment of various microbial infections (skin diseases, diarrhoea and venereal diseases)...
  5. Bilanda D, Dimo T, Dzeufiet Djomeni P, Bella N, Aboubakar O, Nguelefack T, et al. Antihypertensive and antioxidant effects of Allanblackia floribunda Oliv. (Clusiaceae) aqueous extract in alcohol- and sucrose-induced hypertensive rats. J Ethnopharmacol. 2010;128:634-40 pubmed publisher
    Allanblackia floribunda Oliv. (Clusiaceae), an evergreen tree of the rain-forest has long been used in traditional African medicine to treat hypertension...
  6. Tsaffack M, Nguemeving J, Kuete V, Ndejouong Tchize B, Mkounga P, Penlap Beng V, et al. Two new antimicrobial dimeric compounds: febrifuquinone, a vismione-anthraquinone coupled pigment and adamabianthrone, from two Psorospermum species. Chem Pharm Bull (Tokyo). 2009;57:1113-8 pubmed
    ..Their structures were determined using modern spectroscopic methods including one and two dimensional-NMR techniques as well as MS. Compounds 1 and 2 showed significant antimicrobial activities against a wide range of bacteria and fungi...
  7. Acuña U, Figueroa M, Kavalier A, Jancovski N, Basile M, Kennelly E. Benzophenones and biflavonoids from Rheedia edulis. J Nat Prod. 2010;73:1775-9 pubmed publisher
    ..Compound 1 showed significant antioxidant activity in both DPPH and ABTS free radical scavenging assays, whereas compound 2 was inactive. ..
  8. Pecchio M, Solis P, López Pérez J, Vasquez Y, Rodriguez N, Olmedo D, et al. Cytotoxic and antimicrobial benzophenones from the leaves of Tovomita longifolia. J Nat Prod. 2006;69:410-3 pubmed
  9. Souza E, Follett P, Price D, Stacy E. Field suppression of the invasive ant Wasmannia auropunctata (Hymenoptera: Formicidae) in a tropical fruit orchard in Hawaii. J Econ Entomol. 2008;101:1068-74 pubmed
    ..Absolute density estimates from shallow core samples taken from the orchard floor indicated the W. auropunctata supercolony exceeded 244 million ants and 22.7 kg wet weight per ha. ..
  10. Leão M, Gomes S, Pedraza Chaverri J, Machado N, Sousa E, Pinto M, et al. ?-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach. J Nat Prod. 2013;76:774-8 pubmed publisher
    ..Altogether, this work provides a new insight concerning the molecular basis of activity for these compounds. ..
  11. Lenta B, Vonthron Sénécheau C, Weniger B, Devkota K, Ngoupayo J, Kaiser M, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007;12:1548-57 pubmed
    In a preliminary antiprotozoal screening of several Clusiaceae species, the methanolic extracts of Allanblackia monticola and Symphonia globulifera showed high in vitro leishmanicidal activity...
  12. Pieme C, Ambassa P, Yankep E, Saxena A. Epigarcinol and isogarcinol isolated from the root of Garcinia ovalifolia induce apoptosis of human promyelocytic leukemia (HL-60 cells). BMC Res Notes. 2015;8:700 pubmed publisher
    ..the mechanism of apoptosis induced by epigarcinol and isogarcinol isolated from the root of Garcinia ovalifolia (Clusiaceae) on human promyelocytic leukemia (HL-60 cells). Epigarcinol and isogarcinol were isolated from the root of G...
  13. Laphookhieo S, Syers J, Kiattansakul R, Chantrapromma K. Cytotoxic and antimalarial prenylated xanthones from Cratoxylum cochinchinense. Chem Pharm Bull (Tokyo). 2006;54:745-7 pubmed
    ..65 to 5.2 microg/ml. Compounds 1, 2, 6 and 7 also showed antimalarial activity against Plasmodium falciparum with IC(50) values of 3.2, 4.9, 7.2 and 2.6 microg/ml, respectively. ..
  14. Tchakam P, Lunga P, Kowa T, Lonfouo A, Wabo H, Tapondjou L, et al. Antimicrobial and antioxidant activities of the extracts and compounds from the leaves of Psorospermum aurantiacum Engl. and Hypericum lanceolatum Lam. BMC Complement Altern Med. 2012;12:136 pubmed publisher
    ..aurantiacum and H. lanceolatum stem bark possess significant antimicrobial and antioxidant activities justifying the use of these plants in traditional medicine, which may be developed as phytomedicines. ..
  15. Mazumder R, Dastidar S, Basu S, Mazumder A. Effect of Mesua ferrea Linn. flower extract on Salmonella. Indian J Exp Biol. 2005;43:566-8 pubmed
    ..Typhimurium NCTC 74. Further, the extract caused statistically significant reduction in viable count of the strain in liver, spleen and heart blood of challenged mice. ..
  16. Moulari B, Pellequer Y, Lboutounne H, Girard C, Chaumont J, Millet J, et al. Isolation and in vitro antibacterial activity of astilbin, the bioactive flavanone from the leaves of Harungana madagascariensis Lam. ex Poir. (Hypericaceae). J Ethnopharmacol. 2006;106:272-8 pubmed
    ..The minimal inhibitory quantity (MIQs) of astilbin ranged from 50 to 100 microg. ..
  17. Roy S, Kumari N, Pahwa S, Agrahari U, Bhutani K, Jachak S, et al. NorA efflux pump inhibitory activity of coumarins from Mesua ferrea. Fitoterapia. 2013;90:140-50 pubmed publisher
    ..Dose-dependent activity at sub-inhibitory concentration (6.25 ?g/mL) suggested that compounds 4 and 5 are promising EPI compared to verapamil against 1199B and MRSA 831 strains. ..
  18. da Silva A, Oliveira G, Medeiros S, Sousa A, Lopes L, David J, et al. Pre-clinical toxicology of garcinielliptone FC, a tautomeric pair of polyprenylated benzophenone, isolated from Platonia insignis Mart seeds. Phytomedicine. 2016;23:477-82 pubmed publisher
    ..The acute toxicity study indicated that GFC treatment, at selected doses given orally and intraperitoneally, showed relatively low risk of toxicity in all test animals, suggesting that it is safe for further investigation. ..
  19. Verotta L, Lovaglio E, Vidari G, Finzi P, Neri M, Raimondi A, et al. 4-Alkyl- and 4-phenylcoumarins from Mesua ferrea as promising multidrug resistant antibacterials. Phytochemistry. 2004;65:2867-79 pubmed
    ..Biological investigations towards the screening on a number of bacteria strains and Plasmodium falciparum, identified compounds 1-9 as weak antiprotozoal agents and potent antibacterials on resistant Gram-positive strains. ..
  20. Nguemfo E, Dimo T, Dongmo A, Azebaze A, Alaoui K, Asongalem A, et al. Anti-oxidative and anti-inflammatory activities of some isolated constituents from the stem bark of Allanblackia monticola Staner L.C (Guttiferae). Inflammopharmacology. 2009;17:37-41 pubmed publisher
    ..89%, 57.14% and 38.70%, respectively. Methylene chloride fraction of Allanblackia monticola and some derivatives, have antioxidant and anti-inflammatory activities. ..
  21. Djoufack G, Valant Vetschera K, Schinnerl J, Brecker L, Lorbeer E, Robien W. Xanthones, biflavanones and triterpenes from Pentadesma grandifolia (Clusiaceae): structural determination and bioactivity. Nat Prod Commun. 2010;5:1055-60 pubmed
    Stem bark, roots, leaves and fruits of Pentadesma grandifolia Baker f. (Clusiaceae) have been analyzed for the presence of xanthones, biflavonoids and triterpenoids...
  22. Grams T, Thiel S. High light-induced switch from C(3)-photosynthesis to Crassulacean acid metabolism is mediated by UV-A/blue light. J Exp Bot. 2002;53:1475-83 pubmed
    ..Based on these experiments and evidence from the literature, it is suggested that a UV-A/blue light receptor mediates the light-induced C(3)-photosynthesis/CAM switch in C. minor. ..
  23. Kengni F, Fodouop S, Tala D, Djimeli M, Fokunang C, Gatsing D. Antityphoid properties and toxicity evaluation of Harungana madagascariensis Lam (Hypericaceae) aqueous leaf extract. J Ethnopharmacol. 2016;179:137-45 pubmed publisher
    ..The results obtained showed that H. madagascariensis has a promising antisalmonellal effect and, therefore, the potential to provide an effective treatment against salmonellosis, including typhoid fever. ..
  24. Laphookhieo S, Maneerat W, Koysomboon S. Antimalarial and cytotoxic phenolic compounds from Cratoxylum maingayi and Cratoxylum cochinchinense. Molecules. 2009;14:1389-95 pubmed publisher
    ..Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC(50) of 0.22 microg/mL, while vismione B (7) had the highest activity against Plasmodium falciparum, with an IC(50) of 0.66 microg/mL. ..
  25. Branco de Almeida L, Murata R, Franco E, dos Santos M, de Alencar S, Koo H, et al. Effects of 7-epiclusianone on Streptococcus mutans and caries development in rats. Planta Med. 2011;77:40-5 pubmed publisher
    ..05), without reducing the S. mutans viable population from the animals' dental biofilms. In conclusion, the natural compound 7-epiclusianone may be a potentially novel pharmacological agent to prevent and control dental caries disease. ..
  26. Kuete V, Azebaze A, Mbaveng A, Nguemfo E, Tshikalange E, Chalard P, et al. Antioxidant, antitumor and antimicrobial activities of the crude extract and compounds of the root bark of Allanblackia floribunda. Pharm Biol. 2011;49:57-65 pubmed publisher
    ..The overall results of the present work provide baseline information for the potential use of the root bark extract of A. floribunda as an antimicrobial, antitumor and antioxidant phytomedicine. ..
  27. Li P, AnandhiSenthilkumar H, Wu S, Liu B, Guo Z, Fata J, et al. Comparative UPLC-QTOF-MS-based metabolomics and bioactivities analyses of Garcinia oblongifolia. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1011:179-95 pubmed publisher
    Garcinia oblongifolia Champ. ex Benth. (Clusiaceae) is a well-known medicinal plant from southern China, with edible fruits. However, the phytochemistry and bioactivity of the different plant parts of G...
  28. Ngouamegne E, Fongang R, Ngouela S, Boyom F, Rohmer M, Tsamo E, et al. Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. Chem Pharm Bull (Tokyo). 2008;56:374-7 pubmed
    ..All the compounds were found to be active with IC50 values ranging from 7.2 to 23.6 microM. The IC50 of endodesmiadiol was found to be 11.8 microM. ..
  29. Yadav A, Bhatnagar D. Inhibition of iron induced lipid peroxidation and antioxidant activity of Indian spices and Acacia in vitro. Plant Foods Hum Nutr. 2010;65:18-24 pubmed publisher
    ..Cobra's saffron and Acacia showed the highest antioxidant activity, probably due to the higher polyphenol content as compared to other test samples...
  30. Britt A, Randriamandratonirina N, Glasscock K, Iambana B. Diet and feeding behaviour of Indri indri in a low-altitude rain forest. Folia Primatol (Basel). 2002;73:225-39 pubmed
    ..The most important plant families in the diet of Indri were Lauraceae, Clusiaceae and Myristicaceae. Most feeding at Betampona was observed at 5-20 m above the forest floor amongst small (2.1-5...
  31. Ymele E, Dongmo A, Dimo T. Analgesic and anti-inflammatory effect of aqueous extract of the stem bark of Allanblackia gabonensis (Guttiferae). Inflammopharmacology. 2013;21:21-30 pubmed publisher
    ..These results suggest a peripheral and central analgesic activities as well as an anti-inflammatory effect of the stem bark of A. gabonensis. ..
  32. Song J, Liu X, Zhu Y, Han L, Mao C. [Identification on Herba Hyperici Japonici and its adulterant]. Zhong Yao Cai. 2008;31:663-5 pubmed
    ..The distinct characteristic features reveal this study can serve as evidence for the identification of Herba Hyperici Japonici. ..
  33. Pailee P, Kuhakarn C, Sangsuwan C, Hongthong S, Piyachaturawat P, Suksen K, et al. Anti-HIV and cytotoxic biphenyls, benzophenones and xanthones from stems, leaves and twigs of Garcinia speciosa. Phytochemistry. 2018;147:68-79 pubmed publisher
    ..b>Clusiaceae). Their structures were established by extensive spectroscopic analysis...
  34. Mbwambo Z, Apers S, Moshi M, Kapingu M, Van Miert S, Claeys M, et al. Anthranoid compounds with antiprotozoal activity from Vismia orientalis. Planta Med. 2004;70:706-10 pubmed
    A phytochemical investigation of the 80% ethanolic extract of stem bark of Vismia orientalis Engl. (Guttiferae or Clusiaceae), a plant used in traditional medicine in Tanzania, resulted in the isolation and spectroscopic characterisation ..
  35. Zagoto J, Bracht A, Pagadigorria C, Ishii Iwamoto E, Cortez D, Yamamoto N. Effects of the Kielmeyera coriacea extract on energy metabolism in the rat liver. J Ethnopharmacol. 2006;105:47-54 pubmed
    ..The impairment of mitochondrial energy metabolism could lead to adverse metabolic effects by the use of the crude extract, but it could equally be the basis of its antiprotozoan and antifungal effects. ..
  36. Chaturvedula V, Schilling J, Kingston D. New cytotoxic coumarins and prenylated benzophenone derivatives from the bark of Ochrocarpos punctatus from the Madagascar rainforest. J Nat Prod. 2002;65:965-72 pubmed
    ..The structures of compounds 1-10 were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. All compounds exhibited cytotoxicity against the A2780 ovarian cancer cell line. ..
  37. Ovalle Magallanes B, Eugenio Pérez D, Pedraza Chaverri J. Medicinal properties of mangosteen (Garcinia mangostana L.): A comprehensive update. Food Chem Toxicol. 2017;109:102-122 pubmed publisher
    Garcinia mangostana L. (Clusiaceae) is a tropical tree native to Southeast Asia known as mangosteen which fruits possess a distinctive and pleasant taste that has granted them the epithet of "queen of the fruits"...
  38. Awang K, Chan G, Litaudon M, Ismail N, Martin M, Guéritte F. 4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity. Bioorg Med Chem. 2010;18:7873-7 pubmed publisher
    ..AChE) inhibitory activity was observed for the hexane extract from the bark of Mesua elegans (Clusiaceae)...
  39. Ndjakou Lenta B, Devkota K, Ngouela S, Fekam Boyom F, Naz Q, Choudhary M, et al. Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum. Chem Pharm Bull (Tokyo). 2008;56:222-6 pubmed
    ..All tested compounds showed good butyrylcholinesterase inhibition activities with compound 12 displaying the best potency (IC(50) 9.25+/-0.25 microM). All the tested compounds showed weak inhibitory activity against acetylcholinesterase...
  40. Nguemfo E, Dimo T, Azebaze A, Asongalem E, Alaoui K, Dongmo A, et al. Anti-inflammatory and anti-nociceptive activities of the stem bark extracts from Allanblackia monticola STANER L.C. (Guttiferae). J Ethnopharmacol. 2007;114:417-24 pubmed
    ..These results show that Allanblackia monticola has an anti-inflammatory and analgesic activities with gastric ulcerative side effects...
  41. Ndjakou Lenta B, Vonthron Sénécheau C, Fongang Soh R, Tantangmo F, Ngouela S, Kaiser M, et al. In vitro antiprotozoal activities and cytotoxicity of some selected Cameroonian medicinal plants. J Ethnopharmacol. 2007;111:8-12 pubmed
    ..to antiplasmodial activity (SI(a)=14) was established for the methanolic leaf extract of Symphonia globulifera (Clusiaceae), while the methanolic stem bark extract of Albizia zygia showed the best ratio of cytotoxicity to ..
  42. Almeida Cortez J, Melo De Pinna G. Morphology and anatomy of a leaf mine in Vismia guianensis (Aubl.) Choisy (Clusiaceae) in a fragment of Brazilian Atlantic forest. Braz J Biol. 2006;66:759-63 pubmed
    ..There is not a pattern of leaf mining, but the larvae did not consume the druses observed on mesophyll and the vascular tissues of the mid-vein and lateral vein...
  43. Duan Y, Dai Y, Chen L, Liu M, Li Y, Yao X. Xanthones from the stems of Cratoxylum cochinchinense. Magn Reson Chem. 2012;50:642-5 pubmed publisher
    ..The structures of new compounds were determined by extensive spectroscopic analyses, mainly 1D and 2D NMR and HRESIMS data...
  44. Azebaze A, Meyer M, Valentin A, Nguemfo E, Fomum Z, Nkengfack A. Prenylated xanthone derivatives with antiplasmodial activity from Allanblackia monticola STANER L.C. Chem Pharm Bull (Tokyo). 2006;54:111-3 pubmed
    ..45 and 30.46. The antimicrobial activities against a range of microorganisms of the crude extract and some of these compounds are also reported...
  45. Rains K, Nadkarni N, Bledsoe C. Epiphytic and terrestrial mycorrhizas in a lower montane Costa Rican cloud forest. Mycorrhiza. 2003;13:257-64 pubmed
    ..We assessed the mycorrhizal status of epiphytic (Araceae, Clusiaceae, Ericaceae, and Piperaceae) and terrestrial (Clusiaceae, Ericaceae) plants in a lower montane cloud forest in ..
  46. Câmara D, Lemos V, Santos M, Nagem T, Cortes S. Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries. Phytomedicine. 2010;17:690-2 pubmed publisher
  47. Costa Júnior J, de Almeida A, de Barros Falcão Ferraz A, Rossatto R, Silva T, Silva P, et al. Cytotoxic and leishmanicidal properties of garcinielliptone FC, a prenylated benzophenone from Platonia insignis. Nat Prod Res. 2013;27:470-4 pubmed publisher
    Garcinielliptone FC (GFC), a natural prenylated benzophenone, was extracted from Platonia insignis Mart. (Clusiaceae), a native plant commonly known as bacuri and used in traditional Brazilian medicine for the treatment of skin diseases...
  48. Marti G, Eparvier V, Moretti C, Susplugas S, Prado S, Grellier P, et al. Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae). Phytochemistry. 2009;70:75-85 pubmed publisher
    ..The phytochemical investigation of this extract led to the isolation of eleven polycyclic polyprenylated acylphloroglucinols (PPAPs), from which eight showed potent antiplasmodial activity with IC50 ranged from 3.3microM to 37.2microM...
  49. Dutta S, Karak N, Saikia J, Konwar B. Biocompatible epoxy modified bio-based polyurethane nanocomposites: mechanical property, cytotoxicity and biodegradation. Bioresour Technol. 2009;100:6391-7 pubmed publisher
    ..The study reveals that the epoxy modified MFLSO based polyurethane nanocomposites deserve the potential to be applicable as biomaterials...
  50. Baraloto C, Morneau F, Bonal D, Blanc L, Ferry B. Seasonal water stress tolerance and habitat associations within four neotropical tree genera. Ecology. 2007;88:478-89 pubmed
    ..in lowland tropical rain forests of French Guiana, including Virola and Iryanthera (Myristicaceae), Symphonia (Clusiaceae), and Eperua (Caesalpiniaceae)...
  51. Hussein A, Bozzi B, Correa M, Capson T, Kursar T, Coley P, et al. Bioactive constituents from three Vismia species. J Nat Prod. 2003;66:858-60 pubmed
    ..The structure of ferruginin C was elucidated by spectroscopic means. Compounds 6-8 were the most active, and the cytotoxic activity of compounds 2-5 and 7 is reported for the first time...
  52. Moulari B, Lboutounne H, Chaumont J, Guillaume Y, Millet J, Pellequer Y. Potentiation of the bactericidal activity of Harungana madagascariensis Lam. ex Poir. (Hypericaceae) leaf extract against oral bacteria using poly (D, L-lactide-co-glycolide) nanoparticles: in vitro study. Acta Odontol Scand. 2006;64:153-8 pubmed
    ..875 x 10(2) mg/l. Incorporation of the HLE into a colloidal carrier optimized its antibacterial performance...
  53. Jin S, Wang N, Zhang X, Dai Y, Yao X. Two new xanthones from the stems of Cratoxylum cochinchinense. J Asian Nat Prod Res. 2009;11:322-5 pubmed publisher
    ..Blume. Their structures were established on the basis of spectroscopic analysis...
  54. Saraiva L, Fresco P, Pinto E, Kijjoa A, Gonzalez M, Goncalves J. Differential activation of protein kinase C isoforms by euxanthone, revealed by an in vivo yeast phenotypic assay. Planta Med. 2002;68:1039-41 pubmed
    ..Furthermore, euxanthone presents differences on its potency towards individual PKC isoforms, showing a remarkable selectivity for PKC-zeta. These results can help to clarify the molecular basis of the euxanthone-mediated effects...
  55. Olmedo D, López Pérez J, Del Olmo E, Vasquez Y, San Feliciano A, Gupta M. A new cytotoxic friedelane acid--pluricostatic acid--and other compounds from the leaves of Marila pluricostata. Molecules. 2008;13:2915-24 pubmed publisher
    ..The new triterpenoid acid 1 showed cytotoxicity against the MCF-7, H-460, and SF-268 human cancer cell lines with GI(50) values from 1.2 to 3.3 microg/mL...
  56. Tayanin G, Bratthall D. Black teeth: beauty or caries prevention? Practice and beliefs of the Kammu people. Community Dent Oral Epidemiol. 2006;34:81-6 pubmed
    ..To be beautiful and caries-free, Kammu women in Laos and Vietnam habitually paint their teeth black. Although this practice existed for many generations, it is now known only among the elderly...
  57. Leet J, Liu X, Drexler D, Cantone J, Huang S, Mamber S, et al. Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest. J Nat Prod. 2008;71:460-3 pubmed publisher
    ..A new hydroxyprenylated xanthone ( 5) is also described. Xanthones 1 and 4 showed selective in vitro cytotoxicity against ABAE cells (bovine endothelial cell line)...
  58. Obici S, Otobone F, da Silva Sela V, Ishida K, da Silva J, Nakamura C, et al. Preliminary toxicity study of dichloromethane extract of Kielmeyera coriacea stems in mice and rats. J Ethnopharmacol. 2008;115:131-9 pubmed
    Kielmeyera coriacea Mart. (Clusiaceae), known as "Pau Santo" or "Saco de Boi" in the central Brazilian plateau region, is used to treat several tropical diseases...
  59. Liu A, Luo Y, Lin Y. [A review of the study on kudingcha]. Zhong Yao Cai. 2002;25:148-50 pubmed
  60. Tang S, Whiteman M, Peng Z, Jenner A, Yong E, Halliwell B. Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines. Free Radic Biol Med. 2004;36:1575-87 pubmed
  61. Santos J, Calheiros A, Nascimento D, Bérenger A, Amendoeira F, Castro Faria Neto H, et al. Chemical profile and antinociceptive efficacy of Rheedia longifolia leaf extract. J Med Food. 2011;14:1039-45 pubmed publisher
    Different species of the family Clusiaceae, including Rheedia longifolia, are used in folk medicine to treat inflammatory diseases...
  62. Ee G, Lim C, Rahmat A, Lee H. Cytotoxic activities of chemical constituents from Mesua daphnifolia. Trop Biomed. 2005;22:99-102 pubmed
    ..3, 4.0 and 6.7 microg/ml respectively. Meanwhile, the other compounds 1, 2, 3, 5, 6 and 7 gave only selective activities against the cell lines...
  63. Boonsri S, Karalai C, Ponglimanont C, Kanjana Opas A, Chantrapromma K. Antibacterial and cytotoxic xanthones from the roots of Cratoxylum formosum. Phytochemistry. 2006;67:723-7 pubmed
    ..Their structures were established on the basis of analysis of spectroscopic evidence. In addition, antibacterial and cytotoxic activities of the isolates were also evaluated...
  64. Cao S, Brodie P, Miller J, Ratovoson F, Birkinshaw C, Randrianasolo S, et al. Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest. J Nat Prod. 2007;70:686-8 pubmed
    ..Both compounds were tested for their antiproliferative activity against the A2780 human ovarian cancer cell line...
  65. Tiani G, Ahmed I, Krohn K, Green I, Nkengfack A. Kenganthranol F, a new anthranol from Psorospermum aurantiacum. Nat Prod Commun. 2013;8:103-4 pubmed
    ..The structure of the new isomer of kenganthranol F was determined to be 1,8,10-trihydroxy-3,4-[2,2-dimethyldihydropyrano]-6-methyl-2,5-bis-(3,3-dimethylallyl)-anthrone...
  66. Almanza G, Quispe R, Mollinedo P, Rodrigo G, Fukushima O, Villagomez R, et al. Antioxidant and antimutagenic polyisoprenylated benzophenones and xanthones from Rheedia acuminata. Nat Prod Commun. 2011;6:1269-74 pubmed
    ..typhimurium TA102, with or without S9, showed by the compounds 1 (more than 93%) and 4 (more than 88%) at 0.02 microg/plate...
  67. Melo e Silva F, de Paula J, Espindola L. Evaluation of the antifungal potential of Brazilian Cerrado medicinal plants. Mycoses. 2009;52:511-7 pubmed publisher
    ..rubrum, presented geometric means of the MIC values between 170.39 and 23.23 microg ml(-1). Extracts of Cerrado plants are of particular interest as source of new agents for the treatment of dermatophytic infections...
  68. Omer F, Hashim N, Ibrahim M, Dehghan F, Yahayu M, Karimian H, et al. Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G0/G1 cell-cycle arrest. Tumour Biol. 2017;39:1010428317731451 pubmed publisher
    ..Overall, the results for ?-mangostin showed an antiproliferative effect in HL60 via stopping the cell cycle at the G0/G1 phase and prompted the intrinsic apoptosis pathway...
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    ..elegans model in the search for disease-modifying agents to treat Alzheimer's disease and indicate the potential of the extract from C. formosum ssp. pruniflorum as a source for the development of anti-Alzheimer's drugs. ..
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    ..Co-occurrence of the two new benzophenone O-arabinosides along with the biogenetically related 1,5,7-trihydroxy-3-methoxyxanthone was not found...
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    ..Compounds 1 and 5 showed moderate activity against the human small cell lung cancer NCI-H187 cell line with the IC50 values of 3.69 +/- 1.27 microg/mL and 3.08 +/- 0.73 microg/mL, respectively...
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    Rheedia longifolia Planch et Triana belongs to the Clusiaceae family. This plant is widely distributed in Brazil, but its chemical and pharmacological properties have not yet been studied. We report here that leaves aqueous extract of R...
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    ..In contrast, neither acetylation, benzoylation, nor methylation enhanced the cytotoxicity of cochinchinone A (6)...
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    ..An antiplasmodial assay was performed with the isolates, in which compounds 1- 3 and 5 exhibited potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC?? values below 3 µM...
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    ..This last features have carried out to a wrong interpretation that the fruit of this species is a drupe. The embryo is pseudo-conferruminate, with two massive foodstoring cotyledons, rich in starch, firmly attached...
  78. López Pérez J, Olmedo D, Del Olmo E, Vasquez Y, Solis P, Gupta M, et al. Cytotoxic 4-phenylcoumarins from the leaves of Marila pluricostata. J Nat Prod. 2005;68:369-73 pubmed
    ..Their structures were established by spectroscopic means. All compounds were tested in cytotoxicity assays against the MCF-7, H-460, and SF-268 human cancer cell lines...
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    Polyisoprenylated benzophenones have been isolated from plants, particularly in the Clusiaceae family, and their biological properties recently have received considerable attention from a pharmacological point of view...
  80. Murata R, Branco de Almeida L, Franco E, Yatsuda R, Dos Santos M, de Alencar S, et al. Inhibition of Streptococcus mutans biofilm accumulation and development of dental caries in vivo by 7-epiclusianone and fluoride. Biofouling. 2010;26:865-72 pubmed publisher
    ..The data show that 7-epiclusianone is a novel and effective antibiofilm/anticaries agent, which may enhance the cariostatic properties of fluoride...
  81. Rodanant P, Boonnak N, Surarit R, Kuvatanasuchati J, Lertsooksawat W. Antibacterial, anti-inflammatory and anti-oxidatant activities of various isolated compounds from Cratoxylum species. Pak J Pharm Sci. 2017;30:667-674 pubmed
    ..Accordingly, selected pure compounds from plants of Cratoxylum genus might be of benefit in developing medications that are important in treating periodontal diseases...
  82. Duan Y, Dai Y, Wang G, Zhang X, Chen H, Chen J, et al. Bioactive xanthones from the stems of Cratoxylum formosum ssp. pruniflorum. J Nat Prod. 2010;73:1283-7 pubmed publisher
    ..pruniflorum. The structures of the new compounds were established on the basis of extensive spectroscopic data interpretation. In addition, their RXRalpha transcriptional activities were evaluated using an in vitro assay...
  83. Noungoue D, Chaabi M, Ngouela S, Antheaume C, Boyom F, Gut J, et al. Antimalarial compounds from the stem bark of Vismia laurentii. Z Naturforsch C. 2009;64:210-4 pubmed
    ..The structure of all these compounds was elucidated by spectroscopic means. The stem bark extract and compounds 1 and 3 showed good antimalarial activity against the W2 strain of Plasmodium falciparum...
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    ..The putative pathway by which 7-epiclusianone affects cancer cell development may involve cathepsin inhibition...