tripterygium

Summary

Summary: A plant genus of the family CELASTRACEAE that is a source of triterpenoids and diterpene epoxides such as triptolide.

Top Publications

  1. Tao X, Cush J, Garret M, Lipsky P. A phase I study of ethyl acetate extract of the chinese antirheumatic herb Tripterygium wilfordii hook F in rheumatoid arthritis. J Rheumatol. 2001;28:2160-7 pubmed
    To explore the efficacy and safety of ethyl acetate (EA) extracts of the Chinese herbal remedy Tripterygium wilfordii Hook F (TWHF) for treatment of patients with a variety of inflammatory and autoimmune diseases including rheumatoid ..
  2. Ji S, Li L, Wen J, Sha G, Cheng Z, Cheng D, et al. Therapeutic effect of Tripterygium wilfordii on proteinuria associated with sirolimus in renal transplant recipients. Transplant Proc. 2008;40:3474-8 pubmed publisher
    ..The aim of this study was to investigate the therapeutic effects of Tripterygium wilfordii Hook F. (T II) on proteinuria associated with SRL in renal transplant recipients...
  3. Chen M, Ni Y, Duan H, Qiu Y, Guo C, Jiao Y, et al. Mass spectrometry-based metabolic profiling of rat urine associated with general toxicity induced by the multiglycoside of Tripterygium wilfordii Hook. f. Chem Res Toxicol. 2008;21:288-94 pubmed publisher
    ..profiling strategy to elucidate the toxicity in rats induced by orally administered multiglycosides of Tripterygium wilfordii Hook. f. (GTW) in multiple organs including the kidney, liver, and testis...
  4. Ma J, Dey M, Yang H, Poulev A, Pouleva R, Dorn R, et al. Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii. Phytochemistry. 2007;68:1172-8 pubmed
    The extract of Tripterygium wilfordii Hook F...
  5. Horiuch M, Murakami C, Fukamiya N, Yu D, Chen T, Bastow K, et al. Tripfordines A-C, sesquiterpene pyridine alkaloids from Tripterygium wilfordii, and structure anti-HIV activity relationships of Tripterygium alkaloids. J Nat Prod. 2006;69:1271-4 pubmed
    ..pyridine alkaloids, tripfordines A-C (1-3), were isolated from an ethanolic extract of the roots of Tripterygium wilfordii, along with eight known pyridine alkaloids, and tested for in vitro cytotoxic and anti-HIV activity...
  6. Sylvester J, Liacini A, Li W, Dehnade F, Zafarullah M. Tripterygium wilfordii Hook F extract suppresses proinflammatory cytokine-induced expression of matrix metalloproteinase genes in articular chondrocytes by inhibiting activating protein-1 and nuclear factor-kappaB activities. Mol Pharmacol. 2001;59:1196-205 pubmed
    ..The Chinese herbal remedy Tripterygium wilfordii Hook F (TWHF) is effective for treatment of various types of arthritis...
  7. Helmstädter A. Tripterygium wilfordii Hook. f. - how a traditional Taiwanese medicinal plant found its way to the West. Pharmazie. 2013;68:643-6 pubmed
    b>Tripterygium wilfordii is regarded as a promising traditional medicinal plant showing several, mainly antiinflammatory and cytotoxic activities. It contains unusal natural products currently under investigation as lead compounds...
  8. Li J, Lu Y, Xiao C, Lu C, Niu X, He X, et al. Comparison of toxic reaction of Tripterygium wilfordii multiglycoside in normal and adjuvant arthritic rats. J Ethnopharmacol. 2011;135:270-7 pubmed publisher
    b>Tripterygium wilfordii multiglycoside (GTW), an authorized Chinese patent drug, is used for treatment of rheumatoid arthritis and other immune disease...
  9. Tao Q, Ren J, Ji Z, Li J, Wang X, Jiang X. [Maintenance effect of polyglycosides of Tripterygium wilfordii on remission in postoperative Crohn disease]. Zhonghua Wei Chang Wai Ke Za Zhi. 2009;12:491-3 pubmed
    To observe the maintenance effect of polyglycosides of Tripterygium wilfordii (GTW) on remission in postoperative Crohn disease (CD).

More Information

Publications73

  1. Liao N, Ren J, Fan C, Wang G, Zhao Y, Li J. [Efficacy of polyglycosides of Tripterygium wilfordii in preventing postoperative recurrence of Crohn disease]. Zhonghua Wei Chang Wai Ke Za Zhi. 2009;12:167-9 pubmed
    To observe the efficacy of polyglycoside of Tripterygium wilfordii(GTW) in preventing postoperative recurrence of Crohn disease(CD).
  2. Xu G, Tu W, Jiang D, Xu C. Tripterygium wilfordii Hook F treatment for idiopathic refractory nephrotic syndrome in adults: a meta-analysis. Nephron Clin Pract. 2009;111:c223-8 pubmed publisher
    b>Tripterygium wilfordii Hook F (TwHF) is a Chinese herbal medicine with immunosuppressive effects and an established history of use in the treatment of inflammatory and autoimmune diseases...
  3. Yang F, Dong X, An Z, Wu G, Zhang L, Gong N, et al. Retrospect and prospect of studies on Tripterygium Wilfordii Hook f. Chin J Integr Med. 2005;11:89-96 pubmed
  4. Wang X, Gao W, Yao Z, Zhang S, Zhang Y, Takaishi Y, et al. Immunosuppressive sesquiterpenes from Tripterygium wilfordii. Chem Pharm Bull (Tokyo). 2005;53:607-10 pubmed
    ..5), were isolated from the xylem of Tripterygium wilfordii, together with a known compound (6)...
  5. Wang B, Ma L, Tao X, Lipsky P. Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription. Arthritis Rheum. 2004;50:2995-303 pubmed
    The ethyl acetate (EA) extract of Tripterygium wilfordii Hook F (TWHF) and its major active component, triptolide, have been reported to be effective in the treatment of rheumatoid arthritis and other autoimmune inflammatory diseases...
  6. Fu Y, Zhao Z, Wu Y, Wu K, Xu X, Liu Y, et al. Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure. J Ethnopharmacol. 2012;139:26-33 pubmed publisher
    To assess the therapeutic effect of Tongmai Dasheng Tablet (TMDST) on tripterygium glycosides (TG) induced premature ovarian failure (POF) rat model and investigate the underlying mechanisms, based on the establishing method of POF model ..
  7. Wong K, Yuan Y, Luk J. Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents. Clin Exp Pharmacol Physiol. 2012;39:311-20 pubmed publisher
    ..2.?Tripterygium wilfordii (TW) is a medicinal plant that exhibits profound immunosuppressive effects and has been used in ..
  8. Bao J, Dai S. A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety. Rheumatol Int. 2011;31:1123-9 pubmed publisher
    b>Tripterygium wilfordii Hook F (TwHF) is a Chinese herb with immunosuppressive effects and an established history of use in the treatment of rheumatoid arthritis (RA)...
  9. Law S, Simmons M, Techen N, Khan I, He M, Shaw P, et al. Molecular analyses of the Chinese herb Leigongteng (Tripterygium wilfordii Hook.f.). Phytochemistry. 2011;72:21-6 pubmed publisher
    b>Tripterygium wilfordii Hook.f...
  10. He M, Liu L, Ge W, Shaw P, Jiang R, Wu L, et al. Antiangiogenic activity of Tripterygium wilfordii and its terpenoids. J Ethnopharmacol. 2009;121:61-8 pubmed publisher
    b>Tripterygium wilfordii Hook. f. (Celastraceae) has been traditionally used as folk medicine for centuries in China for the treatment of immune-inflammatory diseases.
  11. Yang H, Chen D, Cui Q, Yuan X, Dou Q. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006;66:4758-65 pubmed
    ..an active compound extracted from the root bark of the Chinese medicine "Thunder of God Vine" (Tripterygium wilfordii Hook F.), was used for years as a natural remedy for inflammatory conditions...
  12. Liu S, Cao J, An H. Molecular analysis of Tripterygium hypoglaucum (level) Hutch-induced mutations at the HPRT locus in human promyelocytic leukemia cells by multiplex polymerase chain reaction. Mutagenesis. 2003;18:77-80 pubmed
    The genotoxicity and cytotoxicity of a Chinese medicinal herb, Tripterygium hypoglaucum (level) Hutch (THH), was investigated in human promyelocytic leukemia (HL-60) cells using the hypoxanthine-guanine phosphoribosyltransferase mutation ..
  13. Cibere J, Deng Z, Lin Y, Ou R, He Y, Wang Z, et al. A randomized double blind, placebo controlled trial of topical Tripterygium wilfordii in rheumatoid arthritis: reanalysis using logistic regression analysis. J Rheumatol. 2003;30:465-7 pubmed
    To assess the efficacy of topical Tripterygium wilfordii (TW), a Chinese herbal therapy, in rheumatoid arthritis (RA).
  14. Ren J, Wu X, Liao N, Wang G, Fan C, Liu S, et al. Prevention of postoperative recurrence of Crohn's disease: Tripterygium wilfordii polyglycoside versus mesalazine. J Int Med Res. 2013;41:176-87 pubmed publisher
    To explore effectiveness and safety of polyglycosides of Tripterygium wilfordii (GTW) and mesalazine (5-aminosalicylic acid [5-ASA]) in preventing postoperative clinical and endoscopic recurrence of Crohn's disease.
  15. Lin N, Sato T, Ito A. Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook. f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human syn. Arthritis Rheum. 2001;44:2193-200 pubmed
    Various extracts of the Chinese herbal remedy Tripterygium wilfordii Hook. f. (TWHF) have been reported to be therapeutically efficacious in rheumatoid arthritis (RA) in China, but their mechanism of action remains unclear...
  16. Choi B, Sapkota K, Kim S, Lee H, Choi H, Kim S. Antioxidant activity and protective effects of Tripterygium regelii extract on hydrogen peroxide-induced injury in human dopaminergic cells, SH-SY5Y. Neurochem Res. 2010;35:1269-80 pubmed publisher
    The present work was conducted to investigate the antioxidant activity and neuroprotective effects of Tripterygium regelii extract (TRE) on H(2)O(2)-induced apoptosis in human dopaminergic cells, SH-SY5Y...
  17. Tao X, Younger J, Fan F, Wang B, Lipsky P. Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study. Arthritis Rheum. 2002;46:1735-43 pubmed
    To examine the safety and efficacy of an extract of Tripterygium wilfordii Hook F (TWHF) in the treatment of patients with rheumatoid arthritis (RA).
  18. Tao X, Fan F, Hoffmann V, Gao C, Longo N, Zerfas P, et al. Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F. Arthritis Rheum. 2008;58:1774-83 pubmed publisher
    Triptolide and tripdiolide are thought to be active components of the Chinese antirheumatic herbal remedy Tripterygium wilfordii Hook F, which has been shown to be effective in treating murine lupus nephritis...
  19. Brinker A, Ma J, Lipsky P, Raskin I. Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry. 2007;68:732-66 pubmed
    Plants in the genus Tripterygium, such as Tripterygium wilfordii Hook.f., have a long history of use in traditional Chinese medicine...
  20. Wan Y, Zhao Q, Sun W, Zhang H, Li M, Wei Q, et al. Contrasting dose-effects of multi-glycoside of Tripterygium wilfordii HOOK. f. on glomerular inflammation and hepatic damage in two types of anti-Thy1.1 glomerulonephritis. J Pharmacol Sci. 2012;118:433-46 pubmed
    Multi-glycoside, one of the extracted compounds from Tripterygium wilfordii HOOK. f. (GTW), has been shown to be clinically effective in suppressing glomerular inflammation in chronic kidney disease...
  21. Dan H, Peng R, Ao Y, Liu Y. Segment-specific proximal tubule injury in tripterygium glycosides intoxicated rats. J Biochem Mol Toxicol. 2008;22:422-8 pubmed publisher
    b>Tripterygium glycosides (TG), extracted from the Chinese herb Tripterygium wilfordii Hook. f, is a widely used anti-inflammatory and immunosuppressive agent with definite nephrotoxicity. However, its toxic mechanism remained undiscovered...
  22. Gu M, Zhou H, Xue B, Niu D, He Q, Wang X. [Effect of Chinese herb Tripterygium wilfordii Hook F monomer triptolide on apoptosis of PC12 cells induced by Abeta1-42]. Sheng Li Xue Bao. 2004;56:73-8 pubmed
    ..modle and studied the protective effect and related mechanisms of T(10), monomer extracted from Chinese herb Tripterygium wilfordii Hook F...
  23. Zhou Y, Huang Y, Xu Q, Ye M, Sun C, Zhou D. [Several monomes from Tripterygium wilfordii inhibit proliferation of glioma cells in vitro]. Ai Zheng. 2002;21:1106-8 pubmed
    Researches indicated that Tripterygium wilfordii possess antitumor activity. The current study was designed to investigate inhibitive effect of several monomes of Tripterygium wilfordii on the proliferation of glioma cells.
  24. Li Y, Tong P, Ma H. [Toxicity attenuation and efficacy potentiation effect of liquorice on treatment of rheumatoid arthritis with Tripterygium wilfordii]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006;26:1117-9 pubmed
    To investigate the toxicity attenuation and efficacy potentiation effect of liquorice on treatment of rheumatoid arthritis (RA) with Tripterygium wilfordii (TW).
  25. Yu L, Ao M, Wan J, Zhang Y. Anti-inflammatory effects of leaf and twig of Tripterygium wilfordii on paw edema in mice. Fitoterapia. 2008;79:529-32 pubmed publisher
    The root of Tripterygium wilfordii (TWH) is a traditional Chinese herb used to treat the immune-related diseases such as rheumatoid arthritis, whereas the leaf and twig of TWH was considered useless and discarded...
  26. Zhang W, Shi Q, Zhao L, Li Y, Tang F, Zhang F, et al. The safety and effectiveness of a chloroform/methanol extract of Tripterygium wilfordii Hook F (T2) plus methotrexate in treating rheumatoid arthritis. J Clin Rheumatol. 2010;16:375-8 pubmed publisher
    The objective of the study was to assess the safety and effectiveness of the chloroform/methanol extract of Tripterygium wilfordii Hook F (T2) plus methotrexate (MTX) in treating patients with rheumatoid arthritis (RA).
  27. Kumar D, Lau C, Wan J, Yang D, Hyde K. Immunomodulatory compounds from Pestalotiopsis leucothës, an endophytic fungus from Tripterygium wilfordii. Life Sci. 2005;78:147-56 pubmed
    ..compounds designated BS, GS, and YS produced by Pestalotiopsis leucothës, an endophytic fungus isolated from Tripterygium wilfordii, were evaluated...
  28. Li F, Cheng X, Liang X, Wang X, Xue B, He Q, et al. Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons. Exp Neurol. 2003;179:28-37 pubmed
    ..We investigated whether tripchlorolide, an immunosuppressive extract of Chinese herb Tripterygium wilfordii Hook F, could exert similar neurotrophic and neuroprotective effects similar to those of FK506...
  29. Fidler J, Ku G, Piazza D, Xu R, Jin R, Chen Z. Immunosuppressive activity of the Chinese medicinal plant Tripterygium wilfordii. III. Suppression of graft-versus-host disease in murine allogeneic bone marrow transplantation by the PG27 extract. Transplantation. 2002;74:445-57 pubmed
    PG27 is an active fraction purified from an extract of a Chinese medicinal plant, Tripterygium wilfordii Hook f...
  30. Siva Sundara Kumar D, Cheung H, Lau C, Chen F, Hyde K. In vitro studies of endophytic fungi from Tripterygium wilfordii with anti-proliferative activity on human peripheral blood mononuclear cells. J Ethnopharmacol. 2004;94:295-300 pubmed
    An array of endophytic fungi which habitat in a Chinese medicinal plant, Tripterygium wilfordii Hook. f...
  31. Chen Y, Gao Q, Zhao X, Chen X, Zhang F, Chen J, et al. Meta-analysis of Tripterygium wilfordii Hook F in the immunosuppressive treatment of IgA nephropathy. Intern Med. 2010;49:2049-55 pubmed
    Numerous Chinese patients with IgA nephropathy (IgAN) have benefited from Tripterygium wilfordii Hook F (TwHF) from two decades ago. However, to date there is no systematic evaluation of this remedy for IgAN.
  32. Zeng F, Wang W, Wu Y, Dey M, Ye M, Avery M, et al. Two prenylated and C-methylated flavonoids from Tripterygium wilfordii. Planta Med. 2010;76:1596-9 pubmed publisher
    ..di(3-methyl-2-butenyl)-6-methyflavanone ( 2), and 10 known compounds were isolated from the stems and roots of TRIPTERYGIUM WILFORDII...
  33. Jiang Q, Cao W, Tang X, Jiao J. [Tripterygium wilfordii extract for treating rheumatoid arthritis: systematic review]. Zhongguo Zhong Yao Za Zhi. 2009;34:2637-43 pubmed
    To evaluate the efficacy and safety of Tripterygium wilfordii extract (TWE) in treating rheumatoid arthritis.
  34. Han R, Rostami Yazdi M, Gerdes S, Mrowietz U. Triptolide in the treatment of psoriasis and other immune-mediated inflammatory diseases. Br J Clin Pharmacol. 2012;74:424-36 pubmed publisher
    ..In China an extract of the herb Tripterygium wilfordii Hook F...
  35. Marks W. Tripterygium wilfordii Hook F. versus Sulfasalazine in the treatment of rheumatoid arthritis: a well-designed clinical trial of a botanical demonstrating effectiveness. Fitoterapia. 2011;82:85-7 pubmed publisher
    ..However, the results of a clinical trial that demonstrated the clinical efficacy of Tripterygium wilfordii Hook F...
  36. Goldbach Mansky R, Wilson M, Fleischmann R, Olsen N, Silverfield J, Kempf P, et al. Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial. Ann Intern Med. 2009;151:229-40, W49-51 pubmed
    Extracts of the medicinal plant Tripterygium wilfordii Hook F (TwHF) have been used in China for centuries to treat a spectrum of inflammatory diseases...
  37. Ren J, Tao Q, Wang X, Wang Z, Li J. Efficacy of T2 in active Crohn's disease: a prospective study report. Dig Dis Sci. 2007;52:1790-7 pubmed
    ..The traditional Chinese medicine, Tripterygium wilfordii Hook F (TWHF), has both immunomodulatory and anti-inflammatory activities...
  38. Ji S, Wang Q, Chen J, Sha G, Liu Z, Li L. Clinical trial of Tripterygium Wilfordii Hook F. in human kidney transplantation in China. Transplant Proc. 2006;38:1274-9 pubmed
    ..In this study, the effects of Triptergium Wilfordii Hook F.(T II) were assessed on human kidney allograft rejection and long-term survival...
  39. Bai J, Shi Y. Inhibition of Ca(2+) channels in mouse spermatogenic cells by male antifertility compounds from Tripterygium wilfordii Hook. f. Contraception. 2002;65:441-5 pubmed
    The male antifertility effect of a water-chloroform extract (GTW) from the root xylem of Tripterygium wilfordii has attracted worldwide interest...
  40. Chen Y, Gong Z, Chen X, Tang L, Zhao X, Yuan Q, et al. Tripterygium wilfordii Hook F (a traditional Chinese medicine) for primary nephrotic syndrome. Cochrane Database Syst Rev. 2013;:CD008568 pubmed publisher
    b>Tripterygium wilfordii Hook F (TwHF), a traditional Chinese herbal medicine used as an immunosuppressive agent, has been prescribed in China for patients with primary nephrotic syndrome (NS) for more than two decades...
  41. Li J, Huang D, He L. [Effects of glycosides of Tripterygium wilfordii and Cistanche deserticola on the fertility of male mice]. Zhonghua Nan Ke Xue. 2009;15:569-72 pubmed
    To study the impact of glycosides of tripterygium wilfordii (GTW) on fertility, and the reversibility of this impact following intervention with cistanche deserticola (CD) and after withdrawal of GTW.
  42. Wang X, Zhang Z. [Effect of tripterygium polyglucoside on T-lymphocyte subsets and serum interleukin-5 level in asthma patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21:25-7 pubmed
    To investigate the therapeutic mechanism of Tripterygium polyglucoside (TII) in treating asthma patients.
  43. Zhuang W, Fong C, Cao J, Ao L, Leung C, Cheung H, et al. Involvement of NF-kappaB and c-myc signaling pathways in the apoptosis of HL-60 cells induced by alkaloids of Tripterygium hypoglaucum (levl.) Hutch. Phytomedicine. 2004;11:295-302 pubmed
    b>Tripterygium hypoglaucum (levl.) Hutch (Celastraceae) (THH) root is a Chinese medicinal herb commonly used for treating autoimmune diseases...
  44. Canter P, Lee H, Ernst E. A systematic review of randomised clinical trials of Tripterygium wilfordii for rheumatoid arthritis. Phytomedicine. 2006;13:371-7 pubmed
    b>Tripterygium wilfordii is a Chinese herb with immunosuppressive effects and an established history of use in the treatment of rheumatoid arthritis (RA)...
  45. Yang H, Kim J, Lee J, Lee B, Park K, Shim K, et al. Celastrol isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and -independent pathways in human breast cancer cells. Food Chem Toxicol. 2011;49:527-32 pubmed publisher
    ..was to evaluate the underlying apoptotic mechanisms of celastrol, a major biologically active component of Tripterygium regelii, in human breast adenocarcinoma MCF-7 cells. Celastrol was isolated from T...
  46. Liu Y, Chen H, Yang G. Extract of Tripterygium wilfordii Hook F protect dopaminergic neurons against lipopolysaccharide-induced inflammatory damage. Am J Chin Med. 2010;38:801-14 pubmed
    ..Although it is believed that Chinese herbs, such as Tripterygium wilfordii Hook F, can ease inflammatory diseases, little is known about its benefit to neurodegenerative ..
  47. Qiu D, Kao P. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f. Drugs R D. 2003;4:1-18 pubmed
    Extracts of Tripterygium wilfordii hook. f...
  48. Jie Y, Jia C. Chromosomal composition of micronuclei in mouse NIH 3T3 cells treated with acrylamide, extract of Tripterygium hypoglaucum (level) hutch, mitomycin C and colchicine, detected by multicolor FISH with centromeric and telomeric DNA probes. Mutagenesis. 2001;16:145-9 pubmed
    ..mitomycin (MMC) and colchicine (COL) as well as by acrylamide (AA) and the traditional Chinese medicine Tripterygium hypoglaucum (level) hutch (THH) in NIH 3T3 cells was analyzed by multicolor fluorescence in situ hybridization (..
  49. Liu J, Jiang Z, Xiao J, Zhang Y, Lin S, Duan W, et al. Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines. Phytomedicine. 2009;16:1006-13 pubmed publisher
    ..The results showed that triptolide is much more sensitive to ERalpha-positive MCF-7 cells than to ERalpha-negative MDA-MB-231 cells, and the sensitivity is significantly associated with the ERalpha and p53 status...
  50. Lee J, Lee B, Kim N, Lee J. Celastrol blocks binding of lipopolysaccharides to a Toll-like receptor4/myeloid differentiation factor2 complex in a thiol-dependent manner. J Ethnopharmacol. 2015;172:254-60 pubmed publisher
    b>Tripterygium wilfordii (lei gong teng; Thunder of God Vine), which belongs to the Celastraceae family, has long been used in traditional Chinese medicine to treat inflammation and rheumatoid arthritis...
  51. Xin W, Wang Q, Zhang D, Wang C. A new mechanism of inhibition of IL-1? secretion by celastrol through the NLRP3 inflammasome pathway. Eur J Pharmacol. 2017;814:240-247 pubmed publisher
    ..Celastrol, a pharmacologically active ingredient extracted from Tripterygium wilfordii Hook, has anti-inflammatory activities based on its inhibition of IL-1? secretion...
  52. Cui Y, Wang Q, Zhang D, Wang J, Xiao B, Zheng Y, et al. Triptolide Rescues Spatial Memory Deficits and Amyloid-β Aggregation Accompanied by Inhibition of Inflammatory Responses and MAPKs Activity in APP/PS1 Transgenic Mice. Curr Alzheimer Res. 2016;13:288-96 pubmed
    ..Triptolide, a natural compound extracted from the Chinese medicinal herb Tripterygium wilfordii Hook F., has shown anti-inflammatory effects...
  53. Wang X, Wu Q, Yang X, Zhang L, Wu Y, Lu C. Effects of Celastrol on growth inhibition of U937 leukemia cells through the regulation of the Notch1/NF-kappaB signaling pathway in vitro. Chin J Cancer. 2010;29:385-90 pubmed
    ..05). Celastrol inhibited cell proliferation and induced apoptosis in U937 cells in a concentration-dependent manner. The possible mechanism might be involved in the regulation of a survival signaling pathway, such as Notch or NF-kappaB. ..
  54. Tseng C, Hsu S, Lin C, Wu Y, Lee J, Young K. Celastrol inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK/Nrf2 pathway in human hepatoma cells. Antiviral Res. 2017;146:191-200 pubmed publisher
    Celastrol, a quinone methide triterpene isolated from the root extracts of Tripterygium wilfordii, can greatly induce the gene expression activity of heme oxygenase-1 (HO-1) to achieve disease prevention and control...
  55. Dong X, An Z, Guo Y, Zhou J, Qin T. Effect of triptolide on expression of oxidative carbonyl protein in renal cortex of rats with diabetic nephropathy. J Huazhong Univ Sci Technolog Med Sci. 2017;37:25-29 pubmed publisher
    The traditional Chinese medicine (Tripterygium wilfordiiHook.f., TWH) has been clinically used to treat primary and secondary renal diseases and proteinuria for nearly 40 years...
  56. Jiang H, Jiang D, Huang Y, Chang S. [Experimental study on demyelination and immunological rejection of rats' sciatic nerve allograft with tripterygium wilfordii's pretreatment]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2008;22:1378-83 pubmed
    To investigate the appropriate concentration of tripterygium wilfordii and immunological rejection of rats' sciatic nerve allograft with the tripterygium wilfordii's pretreatment so as to explore tripterygium wilfordii's suppression...
  57. Xiao Y, Chen D, Yan J, Yokoyama Y. Mechanism of action of Tripterygium Wilfordii polyglycoside on experimental endometriosis. Eur J Gynaecol Oncol. 2002;23:63-7 pubmed
    This study was designed to examine the therapeutic effectiveness and mechanism of action of Tripterygium Wilfordii polyglycoside (TWP) in the treatment of endometriosis...
  58. Zhang Y, Jiang Z, Xue M, Zhang S, Wang Y, Zhang L. Toxicogenomic analysis of the gene expression changes in rat liver after a 28-day oral Tripterygium wilfordii multiglycoside exposure. J Ethnopharmacol. 2012;141:170-7 pubmed publisher
    b>Tripterygium wilfordii multiglycoside (GTW), which is an extract derived from Tripterygium wilfordii Hook.f., has been used for the treatment of rheumatoid arthritis and other immune diseases in China...
  59. Cao X, Li C, Yang J, Wei B, Luo Y, Zhang D. [Study on chemical constituents from leaves of Tripterygium wilfordii]. Zhongguo Zhong Yao Za Zhi. 2011;36:1028-31 pubmed
    In order to study the chemical constituents of the leaves of Tripterygium wilfordii and provide references for the bio-active study, we isolated nine compounds from the dried leaves of Tripterygium wilfordii...
  60. OuYang X, Cai M, Chen X, Jin M. Development and validation of a liquid chromatography coupled with atmospheric-pressure chemical ionization ion trap mass spectrometric method for the simultaneous determination of triptolide, tripdiolide, and tripterine in human serum. J Anal Toxicol. 2008;32:737-43 pubmed
    ..9% and 13.0%, respectively. This method was found to effectively and simultaneously determine trace triptolide, tripdiolide, and tripterine in human serum and can be suitable for clinical and toxicological studies. ..
  61. Zhou Z, Yang Y, Ding J, Li Y, Miao Z. Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms. Nat Prod Rep. 2012;29:457-75 pubmed publisher
    Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid triepoxide and multiple biological activities...
  62. Wang J, Wang Y, Shao J, Wang X, Du H. [Immunosuppressive therapies in patients with Graves' ophthalmopathy]. Zhonghua Nei Ke Za Zhi. 2004;43:125-7 pubmed
    ..To compare the efficacy and tolerability of 4 immunosuppressants in treating Graves' ophthalmopathy (GO)...
  63. You G, Liang L, Zheng L, Luo X, Li J, Qiu J. [An observation of repair of burn wound with consanguineous skin pretreated with Tripterygium wilfordii]. Zhonghua Shao Shang Za Zhi. 2002;18:372-4 pubmed
    ..To explore new source of skin for burn wound coverage...
  64. Lin K, Wang C, Qian G. [Effect of Tripterygium wilfordii on Th1, Th2 cytokines production in asthma patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21:22-4 pubmed
    To observe the effect of Tripterygium wilfordii on Th1, Th2 cytokines in asthma patients for further study on the therapeutic mechanism.