ginger

Summary

Summary: Deciduous plant rich in volatile oil (OILS, VOLATILE). It is used as a flavoring agent and has many other uses both internally and topically.

Top Publications

  1. Ajith T, Aswathy M, Hema U. Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity. Food Chem Toxicol. 2008;46:3178-81 pubmed publisher
    ..001) in the Z. officinale (400mg/kg) plus DXN treated group. The nephroprotection is mediated by preventing the DXN-induced decline of renal antioxidant status, and also by increasing the activity of GST. ..
  2. Lin R, Chen C, Lee J, Lu C, Chung L, Yen C. Larvicidal constituents of Zingiber officinale (ginger) against Anisakis simplex. Planta Med. 2010;76:1852-8 pubmed publisher
    ..Zingiberaceae (ginger), against Anisakis simplex. The above compounds kill or reduce spontaneous movement in A. simplex larvae...
  3. Black C, Herring M, Hurley D, O Connor P. Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. J Pain. 2010;11:894-903 pubmed publisher
    b>Ginger has been shown to exert anti-inflammatory effects in rodents, but its effect on human muscle pain is uncertain. Heat treatment of ginger has been suggested to enhance its hypoalgesic effects...
  4. Kundu J, Na H, Surh Y. Ginger-derived phenolic substances with cancer preventive and therapeutic potential. Forum Nutr. 2009;61:182-92 pubmed publisher
    b>Ginger, the rhizomes of Zingiber officinale Roscoe (Zingiberaceae), has widely been used as a spice and condiment in different societies...
  5. Ghasemzadeh A, Jaafar H, Rahmat A. Synthesis of phenolics and flavonoids in ginger (Zingiber officinale Roscoe) and their effects on photosynthesis rate. Int J Mol Sci. 2010;11:4539-55 pubmed publisher
    ..between phenolics and flavonoids synthesis/accumulation and photosynthesis rate was investigated for two Malaysian ginger (Zingiber officinale) varieties grown under four levels of glasshouse light intensity, namely 310, 460, 630 and ..
  6. Kim J, Lee S, Park H, Yang J, Shin T, Kim Y, et al. Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe. Arch Pharm Res. 2008;31:415-8 pubmed publisher
    ..6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53(-/-), c-myc, K-ras) and C2 (genotype: p53(-/-), c-myc, Akt), with ED(50) values of 0.58 microM (C1) and 10.7 microM (C2). ..
  7. Peng F, Tao Q, Wu X, Dou H, Spencer S, Mang C, et al. Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger. Fitoterapia. 2012;83:568-85 pubmed publisher
    Twenty-nine phenolic compounds were isolated from the root bark of fresh (Yunnan) ginger and their structures fully characterized...
  8. Chan K, Atkinson S, Mathee K, Sam C, Chhabra S, Camara M, et al. Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber officinale (ginger) rhizosphere: co-existence of quorum quenching and quorum sensing in Acinetobacter and Burkholderia. BMC Microbiol. 2011;11:51 pubmed publisher
    ..AHL)-dependent QS and QQ strains by investigating a bacterial community associated with the rhizosphere of ginger (Zingiber officinale) growing in the Malaysian rainforest...
  9. Rahnama P, Montazeri A, Huseini H, Kianbakht S, Naseri M. Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial. BMC Complement Altern Med. 2012;12:92 pubmed publisher
    Zingiber officinale R. rhizome (ginger) is a popular spice that has traditionally been used to combat the effects of various inflammatory diseases...

More Information

Publications88

  1. Baliga M, Haniadka R, Pereira M, D Souza J, Pallaty P, Bhat H, et al. Update on the chemopreventive effects of ginger and its phytochemicals. Crit Rev Food Sci Nutr. 2011;51:499-523 pubmed publisher
    The rhizomes of Zingiber officinale Roscoe (Zingiberaceae), commonly known as ginger, is one of the most widely used spice and condiment...
  2. Beattie J, Nicol F, Gordon M, Reid M, Cantlay L, Horgan G, et al. Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: a proteomic and biomarker network analysis. Mol Nutr Food Res. 2011;55 Suppl 2:S203-13 pubmed publisher
    ..We aimed to identify key hepatic pathways targeted by anti-obsogenic ginger phytochemicals fed to mice...
  3. Nievergelt A, Marazzi J, Schoop R, Altmann K, Gertsch J. Ginger phenylpropanoids inhibit IL-1beta and prostanoid secretion and disrupt arachidonate-phospholipid remodeling by targeting phospholipases A2. J Immunol. 2011;187:4140-50 pubmed publisher
    The rhizome of ginger (Zingiber officinale) is employed in Asian traditional medicine to treat mild forms of rheumatoid arthritis and fever...
  4. Ramadan G, El Menshawy O. Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis. Int J Rheum Dis. 2013;16:219-29 pubmed publisher
    ..Here, we evaluated and compared the protective activity of two different doses of mixture of ginger and turmeric rhizomes powder (1 : 1) suspended in distilled water (GTaq) in alleviating both articular and extra-..
  5. Ghasemzadeh A, Jaafar H, Rahmat A. Elevated carbon dioxide increases contents of flavonoids and phenolic compounds, and antioxidant activities in Malaysian young ginger (Zingiber officinale Roscoe.) varieties. Molecules. 2010;15:7907-22 pubmed publisher
    ..b>Ginger varieties are rich in physiologically active phenolics and flavonoids with a range of pharmacological activities...
  6. Shanmugam K, Mallikarjuna K, Kesireddy N, Sathyavelu Reddy K. Neuroprotective effect of ginger on anti-oxidant enzymes in streptozotocin-induced diabetic rats. Food Chem Toxicol. 2011;49:893-7 pubmed publisher
    The aim of the present study was to investigate the effect of ginger on oxidative stress markers in the mitochondrial fractions of cerebral cortex (CC), cerebellum (CB), hippocampus (HC) and hypothalamus (HT) of diabetic rats...
  7. Shati A, Elsaid F. Effects of water extracts of thyme (Thymus vulgaris) and ginger (Zingiber officinale Roscoe) on alcohol abuse. Food Chem Toxicol. 2009;47:1945-9 pubmed publisher
    ..This study aimed to investigate the role of water extracts of thyme (Thymus vulgaris) and ginger (Zingiber officinale Roscoe) as natural product extracts to detoxify the injuries of alcohol abuse on liver and ..
  8. Sahebkar A. Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. World J Gastroenterol. 2011;17:271-2 pubmed publisher
    ..Here, ginger has been hypothesized to prevent NAFLD or blunt its progression via several mechanisms, such as sensitizing ..
  9. Ghlissi Z, Atheymen R, Boujbiha M, Sahnoun Z, Makni Ayedi F, Zeghal K, et al. Antioxidant and androgenic effects of dietary ginger on reproductive function of male diabetic rats. Int J Food Sci Nutr. 2013;64:974-8 pubmed publisher
    This study evaluated the antioxidant and androgenic properties of ginger roots on the reproductive function of male diabetic rats...
  10. Ghasemzadeh A, Jaafar H, Rahmat A. Identification and concentration of some flavonoid components in Malaysian young ginger (Zingiber officinale Roscoe) varieties by a high performance liquid chromatography method. Molecules. 2010;15:6231-43 pubmed publisher
    ..b>Ginger (Zingiber officinale Roscoe) is a famous and widely used herb, especially in Asia, that contains several ..
  11. Kubra I, Jaganmohanrao L. An overview on inventions related to ginger processing and products for food and pharmaceutical applications. Recent Pat Food Nutr Agric. 2012;4:31-49 pubmed
    The rhizome of Zingiber officinale Roscoe (Zingiberaceae), commonly known as ginger, is one of the most widely used spice and condiment...
  12. Hung J, Hsu Y, Li C, Ko Y, Ni W, Huang M, et al. 6-Shogaol, an active constituent of dietary ginger, induces autophagy by inhibiting the AKT/mTOR pathway in human non-small cell lung cancer A549 cells. J Agric Food Chem. 2009;57:9809-16 pubmed publisher
    ..Taken together, these findings suggest that 6-shogaol may be a promising chemopreventive agent against human non-small cell lung cancer. ..
  13. Shanmugam K, Ramakrishna C, Mallikarjuna K, Reddy K. Protective effect of ginger against alcohol-induced renal damage and antioxidant enzymes in male albino rats. Indian J Exp Biol. 2010;48:143-9 pubmed
    ..However, treatment with ethanolic extract of ginger (100 mg/kg, 200 mg/kg body weight, po, once daily for 30 days) these parameters came to normalcy showing the ..
  14. Singh P, Kaur I. Synbiotic (probiotic and ginger extract) loaded floating beads: a novel therapeutic option in an experimental paradigm of gastric ulcer. J Pharm Pharmacol. 2012;64:207-17 pubmed publisher
    This study investigated the use of a bioactive phytochemical, namely ginger extract (GE), for its antioxidant and antiulcer effects, and also for supporting probiotic growth and activity...
  15. Ghasemzadeh A, Jaafar H, Karimi E, Ibrahim M. Combined effect of CO(2) enrichment and foliar application of salicylic acid on the production and antioxidant activities of anthocyanin, flavonoids and isoflavonoids from ginger. BMC Complement Altern Med. 2012;12:229 pubmed publisher
    ..on the production and antioxidant activities of anthocyanin, flavonoids and isoflavonoids from two Malaysian ginger varieties, namely Halia Bentong and Halia Bara...
  16. Kim M, Miyamoto S, Yasui Y, Oyama T, Murakami A, Tanaka T. Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice. Int J Cancer. 2009;124:264-71 pubmed publisher
    Zerumbone (ZER), present in subtropical ginger Zingiber zerumbet Smith, possesses anti-growth and anti-inflammatory properties in several human cancer cell lines...
  17. Ghasemzadeh A, Jaafar H, Rahmat A. Antioxidant activities, total phenolics and flavonoids content in two varieties of Malaysia young ginger (Zingiber officinale Roscoe). Molecules. 2010;15:4324-33 pubmed publisher
    b>Ginger (Zingiber officinale Roscoe) is a well known and widely used herb, especially in Asia, which contains several interesting bioactive constituents and possesses health promoting properties...
  18. Dugasani S, Pichika M, Nadarajah V, Balijepalli M, Tandra S, Korlakunta J. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol. 2010;127:515-20 pubmed publisher
    ..Although gingerols and shogaols are the major bioactive compounds present in Zingiber officinale, their molecular mechanisms of actions and the relationship between their structural features and the activity have not been well studied...
  19. Chen H, Soroka D, Hu Y, Chen X, Sang S. Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol. Mol Nutr Food Res. 2013;57:447-58 pubmed publisher
    Shogaols, a series of major constituents in dried ginger with the most abundant being [6]-, [8]-, and [10]-shogaols, show much higher anticancer potencies than gingerols...
  20. Zick S, Ruffin M, Lee J, Normolle D, Siden R, Alrawi S, et al. Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting. Support Care Cancer. 2009;17:563-72 pubmed publisher
    b>Ginger has been used to treat numerous types of nausea and vomiting. Ginger has also been studied for its efficacy for acute chemotherapy-induced nausea and vomiting (CINV)...
  21. Liu Y, Whelan R, Pattnaik B, Ludwig K, Subudhi E, Rowland H, et al. Terpenoids from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells through the activation of p53. PLoS ONE. 2012;7:e53178 pubmed publisher
    ..Here, we demonstrate that terpenoids present in the Steam Distilled Extract of Ginger (SDGE) are potent inhibitors of proliferation of endometrial cancer cells...
  22. Mostafa O, Eid R, Adly M. Antischistosomal activity of ginger (Zingiber officinale) against Schistosoma mansoni harbored in C57 mice. Parasitol Res. 2011;109:395-403 pubmed publisher
    ..The present work aimed to evaluate antischistosomal activity of crude aqueous extract of ginger against Schistosoma mansoni...
  23. Heitmann K, Nordeng H, Holst L. Safety of ginger use in pregnancy: results from a large population-based cohort study. Eur J Clin Pharmacol. 2013;69:269-77 pubmed publisher
    The objective of the study was to examine the safety of ginger use during pregnancy on congenital malformations and selected pregnancy outcomes.
  24. Chen B, Wu P, Chen K, Fu T, Wang H, Chen C. Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger). J Nat Prod. 2009;72:950-3 pubmed publisher
    In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3) cells were incubated with these ..
  25. Butt M, Sultan M. Ginger and its health claims: molecular aspects. Crit Rev Food Sci Nutr. 2011;51:383-93 pubmed publisher
    ..b>Ginger is one of the classic examples of an herb used for not only culinary preparations but also for unique therapeutic ..
  26. Ling H, Yang H, Tan S, Chui W, Chew E. 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-?B activation. Br J Pharmacol. 2010;161:1763-77 pubmed publisher
    ..However, the antimetastatic potential of shogaols remains unexplored. This study was performed to assess the effects of shogaols against breast cancer cell invasion and to investigate the underlying mechanisms...
  27. ElRokh E, Yassin N, El Shenawy S, Ibrahim B. Antihypercholesterolaemic effect of ginger rhizome (Zingiber officinale) in rats. Inflammopharmacology. 2010;18:309-15 pubmed publisher
    ..Many herbal medicinal products have potential hypocholesterolaemic activity and encouraging safety profiles. However, only a limited amount of clinical research exists to support their efficacy...
  28. Darvishzadeh Mahani F, Esmaeili Mahani S, Komeili G, Sheibani V, Zare L. Ginger (Zingiber officinale Roscoe) prevents the development of morphine analgesic tolerance and physical dependence in rats. J Ethnopharmacol. 2012;141:901-7 pubmed publisher
    b>Ginger (Zingiber officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments such as opiates withdrawal-induced disorders...
  29. Madkor H, Mansour S, Ramadan G. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. Br J Nutr. 2011;105:1210-7 pubmed publisher
    ..The present study aimed to compare the modulatory effects of garlic, ginger, turmeric and their mixture on the metabolic syndrome and oxidative stress in streptozotocin (STZ)-nicotinamide ..
  30. Mohammadbeigi R, Shahgeibi S, Soufizadeh N, Rezaiie M, Farhadifar F. Comparing the effects of ginger and metoclopramide on the treatment of pregnancy nausea. Pak J Biol Sci. 2011;14:817-20 pubmed
    This study assesses the effects of ginger on nausea and vomiting caused by pregnancy and compares it with metoclopramide medicine. This study was a randomized double-blind controlled trial...
  31. Ghayur M, Gilani A, Janssen L. Ginger attenuates acetylcholine-induced contraction and Ca2+ signalling in murine airway smooth muscle cells. Can J Physiol Pharmacol. 2008;86:264-71 pubmed publisher
    ..The past decade has seen increased use of herbal treatments for many chronic illnesses. Ginger (Zingiber officinale) is a common food plant that has been used for centuries in treating respiratory illnesses...
  32. Zick S, Turgeon D, Vareed S, Ruffin M, Litzinger A, Wright B, et al. Phase II study of the effects of ginger root extract on eicosanoids in colon mucosa in people at normal risk for colorectal cancer. Cancer Prev Res (Phila). 2011;4:1929-37 pubmed publisher
    ..b>Ginger has shown downregulation of COX in vitro and decreased incidence/multiplicity of adenomas in rats...
  33. Niempoog S, Pawa K, Amatyakul C. The efficacy of powdered ginger in osteoarthritis of the knee. J Med Assoc Thai. 2012;95 Suppl 1:S59-64 pubmed
    b>Ginger is an effective treatment against nausea and vomiting but there are only a few clinical studies of the effect as an anti-inflammatory or analgesic agent...
  34. Pan M, Hsieh M, Kuo J, Lai C, Wu H, Sang S, et al. 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. Mol Nutr Food Res. 2008;52:527-37 pubmed publisher
    b>Ginger, the rhizome of Zingiber officinale, is a traditional medicine with anti-inflammatory and anticarcinogenic properties...
  35. Waggas A. Neuroprotective evaluation of extract of ginger (Zingiber officinale) root in monosodium glutamate-induced toxicity in different brain areas male albino rats. Pak J Biol Sci. 2009;12:201-12 pubmed
    In this study, the neuroprotective effect of the extract of ginger (Zingiber officinale) was investigated against MSG-induced neurotoxicity of male albino rat. The daily dose (4 mg kg(-1) b.wt.) i.p...
  36. Taha M, Abdul A, Abdullah R, Ibrahim T, Abdelwahab S, Mohan S. Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chem Biol Interact. 2010;186:295-305 pubmed publisher
    Zerumbone (ZER), a monosesquiterpene found in the subtropical ginger (Zingiber zerumbet Smith), possesses antiproliferative properties to several cancer cells lines, including the cervical, skin and colon cancers...
  37. Kleiner Hancock H, Shi R, Remeika A, Robbins D, Prince M, Gill J, et al. Effects of ATRA combined with citrus and ginger-derived compounds in human SCC xenografts. BMC Cancer. 2010;10:394 pubmed publisher
    ..The citrus coumarin, auraptene (AUR), and the ethno-medicinal ginger (Alpinia galanga) phenylpropanoid, 1'-acetoxychavicol acetate (ACA), were previously shown to suppress 12-O-..
  38. Haniadka R, Rajeev A, Palatty P, Arora R, Baliga M. Zingiber officinale (ginger) as an anti-emetic in cancer chemotherapy: a review. J Altern Complement Med. 2012;18:440-4 pubmed publisher
    ..The rhizome of Zingiber officinale, commonly known as ginger, is globally an important spice...
  39. Pillai A, Sharma K, Gupta Y, Bakhshi S. Anti-emetic effect of ginger powder versus placebo as an add-on therapy in children and young adults receiving high emetogenic chemotherapy. Pediatr Blood Cancer. 2011;56:234-8 pubmed publisher
    Chemotherapy-induced nausea and vomiting (CINV) are major adverse effects of chemotherapy. Ginger has been used in postoperative and pregnancy-induced nausea and vomiting...
  40. Koo H, McDowell E, Ma X, Greer K, Kapteyn J, Xie Z, et al. Ginger and turmeric expressed sequence tags identify signature genes for rhizome identity and development and the biosynthesis of curcuminoids, gingerols and terpenoids. BMC Plant Biol. 2013;13:27 pubmed publisher
    b>Ginger (Zingiber officinale) and turmeric (Curcuma longa) accumulate important pharmacologically active metabolites at high levels in their rhizomes...
  41. Zeng G, Zhang Z, Lu L, Xiao D, Zong S, He J. Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats. Rejuvenation Res. 2013;16:124-33 pubmed publisher
    The aim of this study was to assess the ability of a traditional Chinese medicinal ginger root extract (GRE) to prevent behavioral dysfunction in the Alzheimer disease (AD) rat model...
  42. Matsuda A, Wang Z, Takahashi S, Tokuda T, Miura N, Hasegawa J. Upregulation of mRNA of retinoid binding protein and fatty acid binding protein by cholesterol enriched-diet and effect of ginger on lipid metabolism. Life Sci. 2009;84:903-7 pubmed publisher
    ..retinoid binding protein (RBP), heart fatty acid binding protein (H-FABP), and cutaneous fatty acid binding protein (C-FABP), in liver and adipose tissue, and examined the effect of ginger on the expression of these genes.
  43. Li M, Chen P, Yue Q, Li J, Chu R, Zhang W, et al. Pungent ginger components modulates human cytochrome P450 enzymes in vitro. Acta Pharmacol Sin. 2013;34:1237-42 pubmed publisher
    b>Ginger rhizome is used worldwide as a spicy flavor agent...
  44. el Sharaky A, Newairy A, Kamel M, Eweda S. Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats. Food Chem Toxicol. 2009;47:1584-90 pubmed publisher
    ..The bromobenzene (BB)-induced hepatotoxicity comes from its reactive metabolites. The efficacy of different doses of ginger (Zingiber officinalesRose) extract in alleviating hepatotoxicity was investigated in male albino rats...
  45. Renner T, Bragg J, Driscoll H, Cho J, Jackson A, Specht C. Virus-induced gene silencing in the culinary ginger (Zingiber officinale): an effective mechanism for down-regulating gene expression in tropical monocots. Mol Plant. 2009;2:1084-94 pubmed publisher
    ..Zingiberaceae, and that BSMV-VIGS can be applied to specifically down-regulate phytoene desaturase in the culinary ginger Zingiber officinale...
  46. Hamed M, Ali S, El Rigal N. Therapeutic potential of ginger against renal injury induced by carbon tetrachloride in rats. ScientificWorldJournal. 2012;2012:840421 pubmed publisher
    The objective of this study was to evaluate the potential of successive ginger extracts (petroleum ether, chloroform, and ethanol) against nephrotoxicity induced by CCl(4) in rats...
  47. Bak M, Ok S, Jun M, Jeong W. 6-shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice. Molecules. 2012;17:8037-55 pubmed publisher
    The rhizome of ginger (Zingiber officinale Roscoe) is known to have several bioactive compounds including gingerols and shogaols which possess beneficial health properties such as anti-inflammatory and chemopreventive effects...
  48. Brown A, Shah C, Liu J, Pham J, Zhang J, Jadus M. Ginger's (Zingiber officinale Roscoe) inhibition of rat colonic adenocarcinoma cells proliferation and angiogenesis in vitro. Phytother Res. 2009;23:640-5 pubmed publisher
    b>Ginger's (Zingiber officinale Roscoe) natural bioactives, specifically ginger extract and 6-gingerol, were measured for their in vitro inhibition of two key aspects of colon cancer biology--cancer cell proliferation and angiogenic ..
  49. Zielinski H, Del Castillo M, Przygodzka M, Ciesarov√° Z, Kukurov√° K, Zielinska D. Changes in chemical composition and antioxidative properties of rye ginger cakes during their shelf-life. Food Chem. 2012;135:2965-73 pubmed publisher
    Changes in chemical composition and antioxidative properties of rye ginger cakes during their shelf-life were investigated in this study...
  50. Yip Y, Tam A. An experimental study on the effectiveness of massage with aromatic ginger and orange essential oil for moderate-to-severe knee pain among the elderly in Hong Kong. Complement Ther Med. 2008;16:131-8 pubmed publisher
    ..To assess the efficacy of an aromatic essential oil (1% Zingiber officinale and 0.5% Citrus sinesis) massage among the elderly with moderate-to-severe knee pain...
  51. Kota N, Panpatil V, Kaleb R, Varanasi B, Polasa K. Dose-dependent effect in the inhibition of oxidative stress and anticlastogenic potential of ginger in STZ induced diabetic rats. Food Chem. 2012;135:2954-9 pubmed publisher
    b>Ginger is an important medicinal herb has numerous bioactive components and is used in the management, control and/or treatment of diseases including diabetes mellitus...
  52. Huang H, Chiu S, Chang T. Inhibitory effect of [6]-gingerol on melanogenesis in B16F10 melanoma cells and a possible mechanism of action. Biosci Biotechnol Biochem. 2011;75:1067-72 pubmed
    6]-Gingerol is an active component of ginger that shows antipyretic and anti-inflammation activities. To find a novel skin-whitening agent, the melanogeneis inhibitory effects and action mechanisms of [6]-gingerol were investigated...
  53. Tuntiwechapikul W, Taka T, Songsomboon C, Kaewtunjai N, Imsumran A, Makonkawkeyoon L, et al. Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells. J Med Food. 2010;13:1347-54 pubmed publisher
    The rhizome of ginger (Zingiber officinale Roscoe) has been reputed to have many curative properties in traditional medicine, and recent publications have also shown that many agents in ginger possess anticancer properties...
  54. Mahmoud M, Diaai A, Ahmed F. Evaluation of the efficacy of ginger, Arabic gum, and Boswellia in acute and chronic renal failure. Ren Fail. 2012;34:73-82 pubmed publisher
    This study was conducted to evaluate the effects of Zingiber officinale Roscoe (Ginger), Arabic gum (AG), and Boswellia on both acute and chronic renal failure (CRF) and the mechanisms underlying their effects...
  55. Habib S, Makpol S, Abdul Hamid N, Das S, Ngah W, Yusof Y. Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats. Clinics (Sao Paulo). 2008;63:807-13 pubmed
    To evaluate the effect of ginger extract on the expression of NFkappaB and TNF-alpha in liver cancer-induced rats.
  56. Isa Y, Miyakawa Y, Yanagisawa M, Goto T, Kang M, Kawada T, et al. 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2008;373:429-34 pubmed publisher
    In this study, we demonstrated that the two ginger-derived components have a potent and unique pharmacological function in 3T3-L1 adipocytes via different mechanisms...
  57. Ozgoli G, Goli M, Moattar F. Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. J Altern Complement Med. 2009;15:129-32 pubmed publisher
    To compare the effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea.
  58. Uz E, Karatas O, Mete E, Bayrak R, Bayrak O, Atmaca A, et al. The effect of dietary ginger (Zingiber officinals Rosc) on renal ischemia/reperfusion injury in rat kidneys. Ren Fail. 2009;31:251-60 pubmed publisher
    ..The aim of this study was to analyze the possible protective effect of dietary ginger (Zingiber officinals Rosc), a free radical scavenger, on renal I/R injury in rats...
  59. Park G, Kim H, Ju M, Ha S, Park Y, Kim S, et al. 6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation. Acta Pharmacol Sin. 2013;34:1131-9 pubmed publisher
    6-Shogaol [1-(4-hydroxy-methoxyphenyl)-4-decen-one], a pungent compound isolated from ginger, has shown various neurobiological and anti-inflammatory effects...
  60. Ramadan G, Al Kahtani M, El Sayed W. Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation. 2011;34:291-301 pubmed publisher
    Turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes have been widely used as dietary spices and to treat different diseases in Ayurveda/Chinese medicine since antiquity...
  61. Shariatpanahi Z, Taleban F, Mokhtari M, Shahbazi S. Ginger extract reduces delayed gastric emptying and nosocomial pneumonia in adult respiratory distress syndrome patients hospitalized in an intensive care unit. J Crit Care. 2010;25:647-50 pubmed publisher
    The purpose of this study was to evaluate the effect of ginger extract on delayed gastric emptying, developing ventilator-associated pneumonia, and clinical outcomes in adult respiratory distress syndrome (ARDS).
  62. Maghsoudi S, Gol A, Dabiri S, Javadi A. Preventive effect of ginger (Zingiber officinale) pretreatment on renal ischemia-reperfusion in rats. Eur Surg Res. 2011;46:45-51 pubmed publisher
    The present study examined the preventive effect of ginger against renal ischemia-reperfusion (I-R) injury.
  63. Oboh G, Ademiluyi A, Akinyemi A. Inhibition of acetylcholinesterase activities and some pro-oxidant induced lipid peroxidation in rat brain by two varieties of ginger (Zingiber officinale). Exp Toxicol Pathol. 2012;64:315-9 pubmed publisher
    b>Ginger has been reportedly used for the management or treatment of Alzheimer's disease in folklore medicine...
  64. Haleagrahara N, Jackie T, Chakravarthi S, Rao M, Kulur A. Protective effect of Etlingera elatior (torch ginger) extract on lead acetate--induced hepatotoxicity in rats. J Toxicol Sci. 2010;35:663-71 pubmed
    ..The efficacy of Etlingera elatior (torch ginger) to protect hepatotoxicity induced by lead acetate was evaluated experimentally in male Sprague - Dawley rats...
  65. Fujisawa M, Harada H, Kenmoku H, Mizutani S, Misawa N. Cloning and characterization of a novel gene that encodes (S)-beta-bisabolene synthase from ginger, Zingiber officinale. Planta. 2010;232:121-30 pubmed publisher
    b>Ginger, Zingiber officinale Roscoe, contains a fragrant oil mainly composed of sesquiterpenes and monoterpenes. We isolated a cDNA that codes for a sesquiterpene synthase from young rhizomes of ginger, Z...
  66. Asami A, Shimada T, Mizuhara Y, Asano T, Takeda S, Aburada T, et al. Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I). J Nat Med. 2010;64:281-7 pubmed publisher
    ..When these results are combined with those obtained with the labeled compound, it would suggest that [6]-shogaol is mostly metabolized in the body and excreted as metabolites...
  67. Choudhury D, Das A, Bhattacharya A, Chakrabarti G. Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells. Food Chem Toxicol. 2010;48:2872-80 pubmed publisher
    b>Ginger has a long history of use as traditional medicine for varied human disease...
  68. Mehrdad M, Messripour M, Ghobadipour M. The effect of ginger extract on blood urea nitrogen and creatinine in mice. Pak J Biol Sci. 2007;10:2968-71 pubmed
    The present study is going to determine whether ginger has positive or negative effects of kidney. A hydro alcoholic extract of ginger was administered intraperitoneally (IP) every 48 h to male mice for a period of 20 days...
  69. El Abhar H, Hammad L, Gawad H. Modulating effect of ginger extract on rats with ulcerative colitis. J Ethnopharmacol. 2008;118:367-72 pubmed publisher
    b>Ginger rhizomes are used traditionally for management of different gastrointestinal disturbances...
  70. Hsiang C, Lo H, Huang H, Li C, Wu S, Ho T. Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice via modulation of nuclear factor-?B activity and interleukin-1? signalling pathway. Food Chem. 2013;136:170-7 pubmed publisher
    b>Ginger is a commonly used spice with anti-inflammatory potential. Colitis is the common pathological lesion of inflammatory bowel diseases...
  71. Hsu Y, Chen C, Hou M, Tsai E, Jong Y, Hung C, et al. 6-Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human breast cancer cells. Mol Nutr Food Res. 2010;54:1307-17 pubmed publisher
    ..is the first to investigate the anticancer effect of 6-dehydrogingerdione (DGE), an active constituent of dietary ginger, in human breast cancer MDA-MB-231 and MCF-7 cells...
  72. Kubra I, Rao L. An impression on current developments in the technology, chemistry, and biological activities of ginger (Zingiber officinale Roscoe). Crit Rev Food Sci Nutr. 2012;52:651-88 pubmed publisher
    b>Ginger rhizome (Zingiber officinale Roscoe) is widely cultivated as a spice for its aromatic and pungent components. The essential oil and oleoresins from ginger are valuable products responsible for the characteristic flavor and pungency...
  73. Lee H, Park S, Lee M, Kim H, Ryu S, Kim N, et al. 1-Dehydro-[10]-gingerdione from ginger inhibits IKK? activity for NF-?B activation and suppresses NF-?B-regulated expression of inflammatory genes. Br J Pharmacol. 2012;167:128-40 pubmed publisher
    Pungent constituents of ginger (Zingiber officinale) have beneficial effects on inflammatory pain and arthritic swelling. However, the molecular basis for these pharmacological properties is only partially understood...
  74. Pertz H, Lehmann J, Roth Ehrang R, Elz S. Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors. Planta Med. 2011;77:973-8 pubmed publisher
    The herbal drug ginger (Zingiber officinale Roscoe) may be effective for treating nausea, vomiting, and gastric hypomotility. In these conditions, cholinergic M (3) receptors and serotonergic 5-HT (3) and 5-HT (4) receptors are involved...
  75. Hu M, Rayner C, Wu K, Chuah S, Tai W, Chou Y, et al. Effect of ginger on gastric motility and symptoms of functional dyspepsia. World J Gastroenterol. 2011;17:105-10 pubmed publisher
    To evaluate the effects of ginger on gastric motility and emptying, abdominal symptoms, and hormones that influence motility in dyspepsia.
  76. van Breemen R, Tao Y, Li W. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011;82:38-43 pubmed publisher
    b>Ginger roots have been used to treat inflammation and have been reported to inhibit cyclooxygenase (COX)...
  77. Oboh G, Akinyemi A, Ademiluyi A. Antioxidant and inhibitory effect of red ginger (Zingiber officinale var. Rubra) and white ginger (Zingiber officinale Roscoe) on Fe(2+) induced lipid peroxidation in rat brain in vitro. Exp Toxicol Pathol. 2012;64:31-6 pubmed publisher
    ..The present study compares the protective properties of two varieties of ginger [red ginger (Zingiber officinale var...
  78. Abdulrazaq N, Cho M, Win N, Zaman R, Rahman M. Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats. Br J Nutr. 2012;108:1194-201 pubmed
    Zingiber officinale (ZO), commonly known as ginger, has been traditionally used in the treatment of diabetes mellitus. Several studies have reported the hypoglycaemic properties of ginger in animal models...
  79. Black C, O Connor P. Acute effects of dietary ginger on muscle pain induced by eccentric exercise. Phytother Res. 2010;24:1620-6 pubmed publisher
    Zingiber officinale, commonly known as ginger, has analgesic and antiinflammatory properties. The acute effects of ginger on muscle pain, inflammation and dysfunction induced by eccentric exercise were examined...