curcuma

Summary

Summary: A plant genus of the family ZINGIBERACEAE that contains CURCUMIN and curcuminoids.

Top Publications

  1. Intapad S, Saengsirisuwan V, Prasannarong M, Chuncharunee A, Suvitayawat W, Chokchaisiri R, et al. Long-term effect of phytoestrogens from Curcuma comosa Roxb. on vascular relaxation in ovariectomized rats. J Agric Food Chem. 2012;60:758-64 pubmed publisher
    ..The present study investigated the long-term effects of phytoestrogens from Curcuma comosa Roxb. on vascular relaxation of isolated thoracic aorta from ovariectomized (OVX) rats...
  2. Padhye S, Chavan D, Pandey S, Deshpande J, Swamy K, Sarkar F. Perspectives on chemopreventive and therapeutic potential of curcumin analogs in medicinal chemistry. Mini Rev Med Chem. 2010;10:372-87 pubmed
    Curcumin is a natural polyphenol derived from the plant Curcuma longa, commonly called turmeric...
  3. Su J, Sripanidkulchai B, Sripanidkulchai K, Piyachaturawat P, Wara aswapati N. Effect of Curcuma comosa and estradiol on the spatial memory and hippocampal estrogen receptor in the post-training ovariectomized rats. J Nat Med. 2011;65:57-62 pubmed publisher
    b>Curcuma comosa was reported to have uterotrophic effects in ovariectomized (OVX) rats. The present study aims to investigate the plant estrogenic-like effects of C...
  4. Park S, Lim H, Hwang S. Evaluation of antioxidant, rheological, physical and sensorial properties of wheat flour dough and cake containing turmeric powder. Food Sci Technol Int. 2012;18:435-43 pubmed publisher
    ..A 6% substitution of wheat flour with turmeric powder showed acceptable sensory scores which were comparable to those of 0-4% turmeric cakes. This indicated that up to 6% level of turmeric powder might be included in cake formulation. ..
  5. El Shahat M, El Abd S, Alkafafy M, El Khatib G. Potential chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis in rats: myrrh (Commiphora molmol) vs. turmeric (Curcuma longa). Acta Histochem. 2012;114:421-8 pubmed publisher
    ..turmeric (Curcuma longa) in hepatocarcinogenic rats induced by a single intraperitoneal injection of diethylnitrosamine (DENA) (200 ..
  6. Singh G, Kapoor I, Singh P, de Heluani C, de Lampasona M, Catalan C. Comparative study of chemical composition and antioxidant activity of fresh and dry rhizomes of turmeric (Curcuma longa Linn.). Food Chem Toxicol. 2010;48:1026-31 pubmed publisher
    The phytoconstituents of essential oil and ethanol oleoresin of fresh and dry rhizomes of turmeric (Curcuma longa Linn.) were analyzed by GC-MS. The major constituents were aromatic-turmerone (24.4%), alpha-turmerone (20...
  7. Ramadan G, Al Kahtani M, El Sayed W. Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation. 2011;34:291-301 pubmed publisher
    ..05), respectively. The present study proves the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin, which may have beneficial effects against rheumatoid arthritis onset/progression as shown in AIA rat model...
  8. Lekshmi P, Arimboor R, Indulekha P, Menon A. Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes. Int J Food Sci Nutr. 2012;63:832-4 pubmed publisher
    Anti-diabetic capacity of Curcuma longa volatile oil in terms of its ability to inhibit glucosidase activities was evaluated. Turmeric volatile oils inhibited glucosidase enzymes more effectively than the reference standard drug acarbose...
  9. Liu J, Feng L, Zhu M, Wang R, Zhang M, Hu S, et al. The in vitro protective effects of curcumin and demethoxycurcumin in Curcuma longa extract on advanced glycation end products-induced mesangial cell apoptosis and oxidative stress. Planta Med. 2012;78:1757-60 pubmed publisher
    b>Curcuma longa L. (CLL), a traditional herbal medicine, has been widely used for the prevention of diabetic vascular complications in recent years...

More Information

Publications78

  1. Maehara S, Ikeda M, Haraguchi H, Kitamura C, Nagoe T, Ohashi K, et al. Microbial conversion of curcumin into colorless hydroderivatives by the endophytic fungus Diaporthe sp. associated with Curcuma longa. Chem Pharm Bull (Tokyo). 2011;59:1042-4 pubmed
    We investigated the microbial conversion of curcumin (1) using endophytic fungi associated with the rhizome of Curcuma longa (Zingiberaceae). We found that Diaporthe sp...
  2. Xiang Z, Wang X, Cai X, Zeng S. Metabolomics study on quality control and discrimination of three curcuma species based on gas chromatograph-mass spectrometry. Phytochem Anal. 2011;22:411-8 pubmed publisher
    ..To discriminate and assess the quality of Curcuma phaeocaulis, C. kwangsiensis and C. wenyujin from different ecotypes...
  3. Madhu K, Chanda K, Saji M. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology. 2013;21:129-36 pubmed publisher
    b>Curcuma longa Linn. is widely used for the treatment of disorders associated with inflammation and was evaluated for its safety and efficacy in the treatment of painful knee osteoarthritis (OA)...
  4. Tantikanlayaporn D, Robinson L, Suksamrarn A, Piyachaturawat P, Blair H. A diarylheptanoid phytoestrogen from Curcuma comosa, 1,7-diphenyl-4,6-heptadien-3-ol, accelerates human osteoblast proliferation and differentiation. Phytomedicine. 2013;20:676-82 pubmed publisher
    b>Curcuma comosa Roxb. is ginger-family plant used to relieve menopausal symptoms. Previous work showed that C...
  5. Policegoudra R, Aradhya S, Singh L. Mango ginger (Curcuma amada Roxb.)--a promising spice for phytochemicals and biological activities. J Biosci. 2011;36:739-48 pubmed
    Mango ginger (Curcuma amada Roxb.) is a unique spice having morphological resemblance with ginger but imparts a raw mango flavour. The main use of mango ginger rhizome is in the manufacture of pickles and culinary preparations...
  6. Cerný D, Lekić N, Vanova K, Muchova L, Horinek A, Kmoníčková E, et al. Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant system. Fitoterapia. 2011;82:786-91 pubmed publisher
    ..4-fold, p=0.001), but reduced NOS-2 (4.1-fold, p=0.01) expressions. In conclusion, the tuning of CO/NO pathways is important in shedding light on curcumin's cytoprotective effects in this model. ..
  7. Kim J, Gupta S, Park B, Yadav V, Aggarwal B. Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-?B and NF-?B-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis. Mol Nutr Food Res. 2012;56:454-65 pubmed publisher
    ..Our results indicate that turmeric can effectively block the proliferation of tumor cells through the suppression of NF-?B and STAT3 pathways. ..
  8. Nagarathnam R, Rengasamy A, Balasubramanian R. Purification and properties of cysteine protease from rhizomes of Curcuma longa (Linn.). J Sci Food Agric. 2010;90:97-105 pubmed publisher
    Turmeric rhizome (Curcuma domestica Linn.) contains proteases and has proteolytic activity. Curcumin from turmeric rhizomes has been used for healing many ailments, including cancer...
  9. Annadurai R, Neethiraj R, Jayakumar V, Damodaran A, Rao S, Katta M, et al. De Novo transcriptome assembly (NGS) of Curcuma longa L. rhizome reveals novel transcripts related to anticancer and antimalarial terpenoids. PLoS ONE. 2013;8:e56217 pubmed publisher
    ..b>Curcuma longa L...
  10. Wickenberg J, Ingemansson S, Hlebowicz J. Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutr J. 2010;9:43 pubmed publisher
    Previous animal studies have shown that Curcuma (C.) longa lowers plasma glucose. C. longa may thus be a promising ingredient in functional foods aimed at preventing type 2 diabetes. The purpose of the study is to study the effect of C...
  11. Witkin J, Li X. Curcumin, an active constiuent of the ancient medicinal herb Curcuma longa L.: some uses and the establishment and biological basis of medical efficacy. CNS Neurol Disord Drug Targets. 2013;12:487-97 pubmed
    ..Although multiple approaches to this problem are being examined, a solution to the bioavailability issue will be needed to ensure appropriate tissue exposures of curcumin in clinical investigation. Progress in this regard is underway. ..
  12. Cheng S, Wu L, Hsieh Y, Wu C, Chan Y, Chang L, et al. Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells. J Agric Food Chem. 2012;60:9620-30 pubmed
    ..and antitumor activities of aromatic turmerone (ar-turmerone), a volatile turmeric oil isolated from Curcuma longa Linn., have been largely unknown...
  13. Saxena P, Anand S, Saxena N, Bajaj P. Effect of arsenic trioxide on renal functions and its modulation by Curcuma aromatica leaf extract in albino rat. J Environ Biol. 2009;30:527-31 pubmed
    The protective effects of Curcuma aromatica leaf extract were studied on nehrotoxicity induced by arsenic trioxide in albino rats. LD50 estimated for arsenic trioxide was 14.98 mg kg(-1) body weight...
  14. Madkor H, Mansour S, Ramadan G. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. Br J Nutr. 2011;105:1210-7 pubmed publisher
  15. Devaraj S, Esfahani A, Ismail S, Ramanathan S, Yam M. Evaluation of the antinociceptive activity and acute oral toxicity of standardized ethanolic extract of the rhizome of Curcuma xanthorrhiza Roxb. Molecules. 2010;15:2925-34 pubmed publisher
    Ethanolic extract of Curcuma xanthorrhiza was used to evaluate the analgesic and toxicity effects in vivo. The extract was standardized using GC-MS, which showed that 1 mg of Curcuma xanthorrhiza ethanolic extract contains 0...
  16. Sathishkumar M, Sneha K, Yun Y. Immobilization of silver nanoparticles synthesized using Curcuma longa tuber powder and extract on cotton cloth for bactericidal activity. Bioresour Technol. 2010;101:7958-65 pubmed publisher
    ..present study reports the synthesis of silver (Ag) nanoparticles from silver precursor using plant biomaterials, Curcuma longa tuber powder and extract...
  17. Su J, Sripanidkulchai K, Suksamrarn A, Hu Y, Piyachuturawat P, Sripanidkulchai B. Pharmacokinetics and organ distribution of diarylheptanoid phytoestrogens from Curcuma comosa in rats. J Nat Med. 2012;66:468-75 pubmed publisher
    b>Curcuma comosa is widely used as a traditional herbal medicine for gynecological diseases in South East Asia...
  18. Yue G, Chan B, Hon P, Kennelly E, Yeung S, Cassileth B, et al. Immunostimulatory activities of polysaccharide extract isolated from Curcuma longa. Int J Biol Macromol. 2010;47:342-7 pubmed publisher
    Several curcuminoids and sesquiterpenoids isolated from Curcuma longa (CL) have been shown to have many pharmacological activities...
  19. El Sayed N, Ismail K, Ahmed S, Hetta M. In vitro amoebicidal activity of ethanol extracts of Arachis hypogaea L., Curcuma longa L. and Pancratium maritimum L. on Acanthamoeba castellanii cysts. Parasitol Res. 2012;110:1985-92 pubmed publisher
    ..peanut), Curcuma longa L. (turmeric), and Pancratium maritimum L. (sea daffodil) on A. castellanii cysts...
  20. Kaur C, Saraf S. Topical vesicular formulations of Curcuma longa extract on recuperating the ultraviolet radiation-damaged skin. J Cosmet Dermatol. 2011;10:260-5 pubmed publisher
    ..Botanical extracts are multifunctional in nature having various properties like photoprotection, anti-aging, moisturizing, antioxidant, astringent, anti-irritant, and antimicrobial activity...
  21. Weerachayaphorn J, Chuncharunee A, Mahagita C, Lewchalermwongse B, Suksamrarn A, Piyachaturawat P. A protective effect of Curcuma comosa Roxb. on bone loss in estrogen deficient mice. J Ethnopharmacol. 2011;137:956-62 pubmed publisher
    b>Curcuma comosa Roxb. or Wan chak motluk is an indigenous medicinal herb and has traditionally been used among postmenopausal women for relief of unpleasant menopausal symptoms.
  22. Lee K, Kim B, Keum K, Yu H, Kim Y, Chang B, et al. Essential oil of Curcuma longa inhibits Streptococcus mutans biofilm formation. J Food Sci. 2011;76:H226-30 pubmed publisher
    b>Curcuma longa (C. longa) has been used as a spice in foods and as an antimicrobial in Oriental medicine. In this study, we evaluated the inhibitory effects of an essential oil isolated from C...
  23. Taheri S, Abdullah T, Abdullah N, Ahmad Z. Genetic relationships among five varieties of Curcuma alismatifolia (Zingiberaceae) based on ISSR markers. Genet Mol Res. 2012;11:3069-76 pubmed
    The genus Curcuma is a member of the ginger family (Zingiberaceae) that has recently become popular for use as flowering pot plants, both indoors and as patio and landscape plants...
  24. Funk J, Frye J, Oyarzo J, Zhang H, Timmermann B. Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.). J Agric Food Chem. 2010;58:842-9 pubmed publisher
    Turmeric (Curcuma longa L., Zingiberaceae) rhizomes contain two classes of secondary metabolites, curcuminoids and the less well-studied essential oils...
  25. Charoenwanthanang P, Lawanprasert S, Phivthong Ngam L, Piyachaturawat P, Sanvarinda Y, Porntadavity S. Effects of Curcuma comosa on the expression of atherosclerosis-related cytokine genes in rabbits fed a high-cholesterol diet. J Ethnopharmacol. 2011;134:608-13 pubmed publisher
    b>Curcuma comosa has been known to have potential use in cardiovascular diseases, but its immunoregulatory role in atherosclerosis development and liver toxicity has not been well studied...
  26. Liju V, Jeena K, Kuttan R. Acute and subchronic toxicity as well as mutagenic evaluation of essential oil from turmeric (Curcuma longa L). Food Chem Toxicol. 2013;53:52-61 pubmed publisher
    The present study investigated the acute, subchronic and genotoxicity of turmeric essential oil (TEO) from Curcuma longa L...
  27. Soontornchainaksaeng P, Jenjittikul T. Chromosome number variation of phytoestrogen-producing Curcuma (Zingiberaceae) from Thailand. J Nat Med. 2010;64:370-7 pubmed publisher
    Wan-chak-motluk is a Thai local name for native species of Curcuma (Zingiberaceae) that produce phytoestrogen in their rhizomes...
  28. Su J, Sripanidkulchai K, Wyss J, Sripanidkulchai B. Curcuma comosa improves learning and memory function on ovariectomized rats in a long-term Morris water maze test. J Ethnopharmacol. 2010;130:70-5 pubmed publisher
    b>Curcuma comosa extract and some purified compounds from this plant have been reported to have estrogenic-like effects, and estrogen improves learning in some animals and potentially in postmenopausal women; therefore, this study tested ..
  29. Sigrist M, Pinheiro J, Filho J, Zucchi M. Genetic diversity of turmeric germplasm (Curcuma longa; Zingiberaceae) identified by microsatellite markers. Genet Mol Res. 2011;10:419-28 pubmed publisher
    Turmeric (Curcuma longa) is a triploid, vegetatively propagated crop introduced early during the colonization of Brazil...
  30. Kumar A, Prakash A, Dogra S. Protective effect of curcumin (Curcuma longa) against D-galactose-induced senescence in mice. J Asian Nat Prod Res. 2011;13:42-55 pubmed publisher
    ..In conclusion, the present study highlights the therapeutic potential of curcumin against d-galactose induced senescence in mice...
  31. Mythri R, Bharath M. Curcumin: a potential neuroprotective agent in Parkinson's disease. Curr Pharm Des. 2012;18:91-9 pubmed
    ..Curcumin is a polyphenol and an active component of turmeric (Curcuma longa), a dietary spice used in Indian cuisine and medicine...
  32. Chen W, Lu Y, Gao M, Wu J, Wang A, Shi R. Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo. J Ethnopharmacol. 2011;133:220-6 pubmed publisher
    b>Curcuma zedoaria (Berg.) Rosc., a traditional Chinese herb, was used widely but absolutely prohibited for the pregnant in clinic...
  33. Wright L, Frye J, Timmermann B, Funk J. Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) is dependent on extract composition. J Agric Food Chem. 2010;58:9498-504 pubmed publisher
    Extracts prepared from turmeric (Curcuma longa L., [Zingiberaceae]) containing bioactive phenolic curcuminoids were evaluated for bone-protective effects in a hypogonadal rat model of postmenopausal osteoporosis...
  34. Lee J, Oh J, Lee Y. Biliary excretion of curcumin is mediated by multidrug resistance-associated protein 2. Biol Pharm Bull. 2012;35:777-80 pubmed
    ..This study may be helpful to the potential use of curcumin as a treatment for bile duct cancer, and to understanding the genetic polymorphism of Mrp2 for clinical trials of curcumin...
  35. Yue G, Chan B, Hon P, Lee M, Fung K, Leung P, et al. Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food Chem Toxicol. 2010;48:2011-20 pubmed publisher
    The rhizome of Curcuma longa (CL) has been commonly used in Asia as a potential candidate for the treatment of different diseases, including inflammatory disorders and cancers...
  36. Kurapati K, Samikkannu T, Kadiyala D, Zainulabedin S, Gandhi N, Sathaye S, et al. Combinatorial cytotoxic effects of Curcuma longa and Zingiber officinale on the PC-3M prostate cancer cell line. J Basic Clin Physiol Pharmacol. 2012;23:139-46 pubmed publisher
    ..The present study investigates the effects of some medicinal plant extracts from generally recognized as safe plants that may be useful in the prevention and treatment of cancer...
  37. Kamazeri T, Samah O, Taher M, Susanti D, Qaralleh H. Antimicrobial activity and essential oils of Curcuma aeruginosa, Curcuma mangga, and Zingiber cassumunar from Malaysia. Asian Pac J Trop Med. 2012;5:202-9 pubmed publisher
    To analyze the chemical composition of the essential oils of Curcuma aeruginosa (C. aeruginosa), Curcuma mangga (C. mangga), and Zingiber cassumunar (Z. cassumunar), and study their antimicrobial activity.
  38. Neyrinck A, Alligier M, Memvanga P, Névraumont E, Larondelle Y, Préat V, et al. Curcuma longa extract associated with white pepper lessens high fat diet-induced inflammation in subcutaneous adipose tissue. PLoS ONE. 2013;8:e81252 pubmed publisher
    Supra-nutritional doses of curcumin, derived from the spice Curcuma longa, have been proposed as a potential treatment of inflammation and metabolic disorders related to obesity...
  39. Policegoudra R, Rehna K, Rao L, Aradhya S. Antimicrobial, antioxidant, cytotoxicity and platelet aggregation inhibitory activity of a novel molecule isolated and characterized from mango ginger (Curcuma amada Roxb.) rhizome. J Biosci. 2010;35:231-40 pubmed
    Mango ginger (Curcuma amada Roxb.) rhizome is used in the manufacture of pickles and other food preparations due to its unique raw mango flavour...
  40. Ferreira F, Kemmelmeier C, Arrotéia C, da Costa C, Mallmann C, Janeiro V, et al. Inhibitory effect of the essential oil of Curcuma longa L. and curcumin on aflatoxin production by Aspergillus flavus Link. Food Chem. 2013;136:789-93 pubmed publisher
    ..Turmeric, Curcuma longa L., is a native plant of Southeast Asia and has antimicrobial, antioxidant and antifungal properties...
  41. Liu Z, Zhao N, Liu C, Zhou L, Du S. Identification of insecticidal constituents of the essential oil of Curcuma wenyujin rhizomes active against Liposcelis bostrychophila Badonnel. Molecules. 2012;17:12049-60 pubmed publisher
    ..aim of this research was to determine the chemical composition and insecticidal activity of the essential oil of Curcuma wenyujin Y.H. Chen et C...
  42. Matsumoto T, Nakamura S, Nakashima S, Yoshikawa M, Fujimoto K, Ohta T, et al. Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells. Bioorg Med Chem Lett. 2013;23:5178-81 pubmed publisher
    The methanolic extract from the dried rhizomes of Curcuma comosa cultivated in Thailand was found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells...
  43. Salama S, Abdulla M, Alrashdi A, Ismail S, Alkiyumi S, Golbabapour S. Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats. BMC Complement Altern Med. 2013;13:56 pubmed publisher
    ..Thus, this study evaluated mechanisms of the hepatoprotective activity of Curcuma longa rhizome ethanolic extract (CLRE) on thioacetamide-induced liver cirrhosis in rats.
  44. Taty Anna K, Elvy Suhana M, Das S, Faizah O, Hamzaini A. Anti-inflammatory effect of Curcuma longa (turmeric) on collagen-induced arthritis: an anatomico-radiological study. Clin Ter. 2011;162:201-7 pubmed
    b>Curcuma longa (CL) or turmeric is an Ayurvedic herb that has been traditionally used to treat inflammatory conditions like rheumatoid arthritis (RA)...
  45. Packiavathy I, Priya S, Pandian S, Ravi A. Inhibition of biofilm development of uropathogens by curcumin - an anti-quorum sensing agent from Curcuma longa. Food Chem. 2014;148:453-60 pubmed publisher
    ..In the present investigation, an anti-quorum sensing (anti-QS) agent curcumin from Curcuma longa (turmeric) was shown to inhibit the biofilm formation of uropathogens, such as Escherichia coli, ..
  46. Schaffer M, Schaffer P, Zidan J, Bar Sela G. Curcuma as a functional food in the control of cancer and inflammation. Curr Opin Clin Nutr Metab Care. 2011;14:588-97 pubmed publisher
    ..Turmeric is a spice that comes from the root Curcuma longa...
  47. Karim M, Haque A, Islam K, Ali N, Salam K, Saud Z, et al. Protective effects of the dietary supplementation of turmeric (Curcuma longa L.) on sodium arsenite-induced biochemical perturbation in mice. Bangladesh Med Res Counc Bull. 2010;36:82-8 pubmed
    ..Therefore, ameliorating effect of turmeric on Sa-treated mice suggested the future application of turmeric to reduce or to prevent arsenic toxicity in human...
  48. Bamba Y, Yun Y, Kunugi A, Inoue H. Compounds isolated from Curcuma aromatica Salisb. inhibit human P450 enzymes. J Nat Med. 2011;65:583-7 pubmed publisher
    b>Curcuma species (Zingiberaceae) are used as both food and medicine in Asia. Ten sesquiterpenes (1-10) and two curcuminoids (11 and 12) were isolated from the rhizomes of Curcuma aromatica Salisb. and identified...
  49. Haddad M, Sauvain M, Deharo E. Curcuma as a parasiticidal agent: a review. Planta Med. 2011;77:672-8 pubmed publisher
    Members of the Curcuma plant species (Zingiberaceae) have been used for centuries in cooking, cosmetics, staining and in traditional medicine as "omnipotent" remedies...
  50. Adaramoye O, Odunewu A, Farombi E. Hepatoprotective effect of Curcuma longa L. in D-galactosamine induced liver injury in mice: evidence of antioxidant activity. Afr J Med Med Sci. 2010;39 Suppl:27-34 pubmed
    The aim of this study was to investigate the hepatoprotective effect of methanolic extract of Curcuma longa L (CLME) in D-galactosamine (GNH2) induced liver injury and the mechanism(s) involved...
  51. Orellana Paucar A, Serruys A, Afrikanova T, Maes J, De Borggraeve W, Alen J, et al. Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models. Epilepsy Behav. 2012;24:14-22 pubmed publisher
    Turmeric, obtained from the rhizomes of Curcuma longa, is used in South Asia as a traditional medicine for the treatment of epilepsy...
  52. Weerachayaphorn J, Chuncharunee A, Jariyawat S, Lewchalermwong B, Amonpatumrat S, Suksamrarn A, et al. Protection of centrilobular necrosis by Curcuma comosa Roxb. in carbon tetrachloride-induced mice liver injury. J Ethnopharmacol. 2010;129:254-60 pubmed publisher
    To investigate the protective effect and possible mechanism of Curcuma comosa hexane extract on CCl(4)-induced liver injury in adult male mice.
  53. Pistelli L, Bertoli A, Gelli F, Bedini L, Ruffoni B, Pistelli L. Production of Curcuminoids in different in vitro organs of Curcuma longa. Nat Prod Commun. 2012;7:1037-42 pubmed
    b>Curcuma longa L. (turmeric) is one of the most important spice and safe food additives. Its main constituents, curcuminoids, showed anti-inflammatory, antitumor and antioxidant effects...
  54. Balaji S, Chempakam B. Toxicity prediction of compounds from turmeric (Curcuma longa L). Food Chem Toxicol. 2010;48:2951-9 pubmed publisher
    ..Hence, the cost-effective approach presented in this paper could be used to filter toxic compounds from the drug discovery lifecycle...
  55. Lee H, Li L, Kim H, Bilehal D, Li W, Lee D, et al. The protective effects of Curcuma longa Linn. extract on carbon tetrachloride-induced hepatotoxicity in rats via upregulation of Nrf2. J Microbiol Biotechnol. 2010;20:1331-8 pubmed
    This study was designed to investigate the potentially protective effects of Curcuma longa Linn. extract (CLE) on carbon tetrachloride (CCl4)-induced hepatotoxicity in rats...
  56. Liao K, Wu M, Chen P, Huang S, Chiu S, Ho C, et al. Curcuminoids promote neurite outgrowth in PC12 cells through MAPK/ERK- and PKC-dependent pathways. J Agric Food Chem. 2012;60:433-43 pubmed publisher
    Curcuminoids, the predominant polyphenolic compounds in the rhizome of Curcuma longa Linn., consist of curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC)...
  57. Lee J, Yoon H, Lee Y, Park J, You Y, Kim K, et al. The potential effects of ethyl acetate fraction from Curcuma longa L. on lipolysis in differentiated 3T3-L1 adipocytes. J Med Food. 2010;13:364-70 pubmed publisher
    The effects of the turmeric ethyl acetate fraction (TEF) from the methanolic extract from Curcuma longa L. on lipid metabolism and underlying mechanisms of lipolysis were investigated in 3T3-L1 adipocytes...
  58. Mohankumar S, McFarlane J. An aqueous extract of Curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro. Phytother Res. 2011;25:396-401 pubmed publisher
    b>Curcuma longa (turmeric) has been used widely as a spice, particularly in Asian countries. It is also used in the Ayurvedic system of medicine as an antiinflammatory and antimicrobial agent and for numerous other curative properties...
  59. Prakash P, Misra A, Surin W, Jain M, Bhatta R, Pal R, et al. Anti-platelet effects of Curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis. Thromb Res. 2011;127:111-8 pubmed publisher
    Extensive research on the mechanism of action and medicinal importance of curcumin obtained from turmeric (Curcuma longa) has unfolded its potential therapeutic value against many chronic ailments. Curcuma oil (C...
  60. Kimura Y, Sumiyoshi M, Tamaki T. Effects of the extracts and an active compound curcumenone isolated from Curcuma zedoaria rhizomes on alcohol-induced drunkenness in mice. Fitoterapia. 2013;84:163-9 pubmed publisher
    The Curcuma zedoaria rhizome has been used traditionally to treat gastrointestinal diseases as an aromatic stomachic drug, and this is currently used to treat alcohol-induced loss of appetite and nausea in Japan...
  61. Das A, Kesari V, Satyanarayana V, Parida A, Rangan L. Genetic relationship of Curcuma species from Northeast India using PCR-based markers. Mol Biotechnol. 2011;49:65-76 pubmed publisher
    Molecular genetic fingerprints of nine Curcuma species from Northeast India were developed using PCR-based markers...
  62. Sindhu S, Chempakam B, Leela N, Suseela Bhai R. Chemoprevention by essential oil of turmeric leaves (Curcuma longa L.) on the growth of Aspergillus flavus and aflatoxin production. Food Chem Toxicol. 2011;49:1188-92 pubmed publisher
    Turmeric is well known for a wide range of medicinal properties. Essential oil of turmeric leaves (Curcuma longa L.) were evaluated at varying concentrations of 0.01, 0.05, 0.1, 0.5, 0.75, 1.0 and 1...
  63. Shehzad A, Ha T, Subhan F, Lee Y. New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. Eur J Nutr. 2011;50:151-61 pubmed publisher
    ..knowledge regarding the anti-obesity role of curcumin (diferuloylmethane), which is isolated from the herb curcuma longa, known to possess anti-inflammatory activities...
  64. Yiu W, Kwan P, Wong C, Kam T, Chiu S, Chan S, et al. Attenuation of fatty liver and prevention of hypercholesterolemia by extract of Curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase. J Food Sci. 2011;76:H80-9 pubmed publisher
    The extract of?Curcuma longa, better known as turmeric, was orally administered to experimental rats that were fed a high-cholesterol diet to investigate whether it could regulate plasma lipids and cholesterol levels and possibly improve ..
  65. Xia Q, Wang X, Xu D, Chen X, Chen F. Inhibition of platelet aggregation by curdione from Curcuma wenyujin essential Oil. Thromb Res. 2012;130:409-14 pubmed publisher
    ..The purpose of the study was to explore an inhibitor of platelet aggregation, which promised to be a preventive or therapeutic agent for various vascular diseases...
  66. Shameli K, Ahmad M, Zamanian A, Sangpour P, Shabanzadeh P, Abdollahi Y, et al. Green biosynthesis of silver nanoparticles using Curcuma longa tuber powder. Int J Nanomedicine. 2012;7:5603-10 pubmed publisher
    ..nanoparticles were biosynthesized from aqueous silver nitrate through a simple and eco-friendly route using Curcuma longa tuber-powder extracts, which acted as a reductant and stabilizer simultaneously...
  67. Hu B, Shen K, An H, Wu Y, Du Q. Aqueous extract of Curcuma aromatica induces apoptosis and G2/M arrest in human colon carcinoma LS-174-T cells independent of p53. Cancer Biother Radiopharm. 2011;26:97-104 pubmed publisher
    b>Curcuma aromatica is a common Chinese herb for treating diseases with blood stasis and has been regarded as an anticancer herb in modern clinical practice...
  68. Joshi R, Mohanty S, Subudhi E, Nayak S. Isolation and characterization of NBS-LRR- resistance gene candidates in turmeric (Curcuma longa cv. surama). Genet Mol Res. 2010;9:1796-806 pubmed publisher
    Turmeric (Curcuma longa), an important asexually reproducing spice crop of the family Zingiberaceae is highly susceptible to bacterial and fungal pathogens...
  69. Bao W, Li K, Rong S, Yao P, Hao L, Ying C, et al. Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction. J Ethnopharmacol. 2010;128:549-53 pubmed publisher
    Curcumin is the main bioactive constituent derived from the rhizome of turmeric (Curcuma longa Linn.), which has been used traditionally as hepatoprotective agents in ayurvedic and traditional Chinese medicine for centuries.