alpinia

Summary

Summary: A plant genus of the family ZINGIBERACEAE. Members contain galangin, yakuchinone-A, and diarylheptanoids.

Top Publications

  1. Khattak S, Saeed ur Rehman -, Ullah Shah H, Ahmad W, Ahmad M. Biological effects of indigenous medicinal plants Curcuma longa and Alpinia galanga. Fitoterapia. 2005;76:254-7 pubmed
    The ethanolic extracts of Curcuma longa and Alpinia galanga exhibited excellent (100%) phytotoxic activity against Lemma minor...
  2. Roy S, Pahwa S, Nandanwar H, Jachak S. Phenylpropanoids of Alpinia galanga as efflux pump inhibitors in Mycobacterium smegmatis mc² 155. Fitoterapia. 2012;83:1248-55 pubmed publisher
    ..5, 6.25 and 5.0 mg/L respectively. 1'-S-1'-acetoxyeugenol acetate enhanced the accumulation and inhibited the efflux of EtBr in Mycobacterium smegmatis mc² 155 cells...
  3. Trakranrungsie N, Chatchawanchonteera A, Khunkitti W. Ethnoveterinary study for antidermatophytic activity of Piper betle, Alpinia galanga and Allium ascalonicum extracts in vitro. Res Vet Sci. 2008;84:80-4 pubmed
    Crude ethanolic extracts of Piper betle leaves (Piperaceae), Alpinia galanga rhizomes (Zingiberaceae) and Allium ascalonicum bulbs (Liliaceae) were tested against selected zoonotic dermatophytes (Microsporum canis, Microsporum gypseum ..
  4. Aziz A, Ibrahim H, Rosmy Syamsir D, Mohtar M, Vejayan J, Awang K. Antimicrobial compounds from Alpinia conchigera. J Ethnopharmacol. 2013;145:798-802 pubmed publisher
    The rhizome of Alpinia conchigerahas been used as a condiment in the northern states of Peninsular Malaysia and occasionally in folk medicine in the east coast to treat fungal infections...
  5. Luo J, Rui W, Jiang M, Tian Q, Ji X, Feng Y. Separation and identification of diarylheptanoids in supercritical fluid extract of Alpinia officinarum by UPLC-MS-MS. J Chromatogr Sci. 2010;48:795-801 pubmed
    ..MS) was developed to identify and characterize the diarylheptanoids in the supercritical fluid extract (SFE) of Alpinia officinarum...
  6. Lin L, Peng C, Liang Y, Yeh W, Wang H, Yu T, et al. Alpinia zerumbet potentially elevates high-density lipoprotein cholesterol level in hamsters. J Agric Food Chem. 2008;56:4435-43 pubmed publisher
    In folkloric plant medicines, Alpinia zerumbet (AZ) has been popularly recognized as an exellent hepatoprotector...
  7. Tabata K, Yamazaki Y, Okada M, Fukumura K, Shimada A, Sun Y, et al. Diarylheptanoids derived from Alpinia officinarum induce apoptosis, S-phase arrest and differentiation in human neuroblastoma cells. Anticancer Res. 2009;29:4981-8 pubmed
    ..natural products for their cytotoxic effects on neuroblastoma cell lines, and two diarylheptanoids derived from Alpinia officinarum, 7-(4''-hydroxy-3''-methoxyphenyl)-1-phenyl-4E-hepten-3-one (Compound 1) and (5R)-5-methoxy-7-(4''-..
  8. Matsuda H, Pongpiriyadacha Y, Morikawa T, Ochi M, Yoshikawa M. Gastroprotective effects of phenylpropanoids from the rhizomes of Alpinia galanga in rats: structural requirements and mode of action. Eur J Pharmacol. 2003;471:59-67 pubmed
    The effects of 1'S-1'-acetoxychavicol acetate and related phenylpropanoids isolated from the rhizomes of Alpinia galanga on ethanol-induced gastric lesions in rats were examined...
  9. Tang J, Li N, Dai H, Wang K. [Chemical constituents from seeds of Alpinia katsumadai, inhibition on NF-kappaB activation and anti-tumor effect]. Zhongguo Zhong Yao Za Zhi. 2010;35:1710-4 pubmed

More Information

Publications73

  1. Chow Y, Lee K, Vidyadaran S, Lajis N, Akhtar M, Israf D, et al. Cardamonin from Alpinia rafflesiana inhibits inflammatory responses in IFN-?/LPS-stimulated BV2 microglia via NF-?B signalling pathway. Int Immunopharmacol. 2012;12:657-65 pubmed publisher
    ..of the treatment spectrum, our group has shown that cardamonin (2',4'-dihydroxy-6'-methoxychalcone) isolated from Alpinia rafflesiana exerts potential anti-inflammatory activity in activated macrophages...
  2. Malek S, Phang C, Ibrahim H, Norhanom A, Sim K. Phytochemical and cytotoxic investigations of Alpinia mutica rhizomes. Molecules. 2011;16:583-9 pubmed publisher
    The methanol and fractionated extracts (hexane, ethyl acetate and water) of Alpinia mutica (Zingiberaceae) rhizomes were investigated for their cytotoxic effect against six human carcinoma cell lines, namely KB, MCF7, A549, Caski, HCT116,..
  3. Chuang C, Wang H, Peng C, Chen K, Peng R. Hypolipidemic effects of different angiocarp parts of Alpinia zerumbet. Pharm Biol. 2011;49:1257-64 pubmed publisher
    In utilization of Alpinia zerumbet (Pers.) Burtt and Smith (Zingiberaceae) (AZ), usually the angiocarps are discarded without further use. We speculate whether the angiocarps could show hypolipidemic effect...
  4. Padalia R, Verma R, Sundaresan V, Chanotiya C. Chemical diversity in the genus Alpinia (Zingiberaceae): comparative composition of four Alpinia species grown in Northern India. Chem Biodivers. 2010;7:2076-87 pubmed publisher
    The essential-oil compositions of leaves, flowers, and rhizomes of Alpinia galanga (L.) Willd., Alpinia calcarata Rosc., Alpinia speciosa K. Schum., and Alpinia allughas Rosc. were examined and compared by capillary GC and GC/MS...
  5. Arambewela L, Arawwawala L, Ratnasooriya W. Antinociceptive activities of aqueous and ethanolic extracts of Alpinia calcarata rhizomes in rats. J Ethnopharmacol. 2004;95:311-6 pubmed
    Rhizomes of Alpinia calcarata Roscoe (Zingiberaceae) posses several bio-activities and are used in traditional medicine of Sri Lanka. However, their antinociceptive activity has not been investigated so far...
  6. Chompoo J, Upadhyay A, Fukuta M, Tawata S. Effect of Alpinia zerumbet components on antioxidant and skin diseases-related enzymes. BMC Complement Altern Med. 2012;12:106 pubmed publisher
    ..b>Alpinia zerumbet, a traditionally important economic plant in Okinawa, contains several interesting bioactive ..
  7. Wang H, Liu T, Zhu Y, Guan S, Ma X, Cui Z. Effect of protocatechuic acid from Alpinia oxyphylla on proliferation of human adipose tissue-derived stromal cells in vitro. Mol Cell Biochem. 2009;330:47-53 pubmed publisher
    The effect of protocatechuic acid (PCA) from Alpinia oxyphylla and catapol from Rehmannia on the proliferation capacity of human adipose tissue-derived stromal cells (hADSCs) was investigated in vitro...
  8. Yang X, Rohr M, Jordan J. Identification of dihydrogalangal acetate in galangal [Alpinia galangal (L.) Swartz] extracts. J Agric Food Chem. 2009;57:3286-90 pubmed publisher
    Dihydrogalangal acetate has been discovered for the first time in galangal roots [Alpinia galangal (L.) Swartz]...
  9. Latha C, Shriram V, Jahagirdar S, Dhakephalkar P, Rojatkar S. Antiplasmid activity of 1'-acetoxychavicol acetate from Alpinia galanga against multi-drug resistant bacteria. J Ethnopharmacol. 2009;123:522-5 pubmed publisher
    b>Alpinia galanga (L.) Swartz is traditionally used in the treatment of various ailments across India, China, and Southeast Asian countries...
  10. Xu J, Tan N, Zeng G, Han H, Huang H, Ji C, et al. [Studies on chemical constituents in fruit of Alpinia oxyphylla]. Zhongguo Zhong Yao Za Zhi. 2009;34:990-3 pubmed
    To study the chemical constituents in fruit of Alpinia oxyphylla and their cytotoxicities on cancer cell lines.
  11. Gröblacher B, Kunert O, Bucar F. Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis. Bioorg Med Chem. 2012;20:2701-6 pubmed publisher
    ..2), (3S,5S)-trans-1,7-diphenylhept-1-ene-3,5-diol (3) and the flavonoid pinocembrin (4), from Alpinia katsumadai, Zingiberaceae, were examined for their antimycobacterial activity and their synergistic effects with ..
  12. Zhang J, Wang S, Li Y, Xu P, Chen F, Tan Y, et al. Anti-diarrheal constituents of Alpinia oxyphylla. Fitoterapia. 2013;89:149-56 pubmed publisher
    Isolation, screening and in vivo assays have been used for evaluating anti-diarrhea bioactive of Alpinia oxyphylla...
  13. Ghosh S, Indukuri K, Bondalapati S, Saikia A, Rangan L. Unveiling the mode of action of antibacterial labdane diterpenes from Alpinia nigra (Gaertn.) B. L. Burtt seeds. Eur J Med Chem. 2013;66:101-5 pubmed publisher
    ..A) and its epoxide analogue, (E)-8?, 17-Epoxylabd-12-ene-15, 16-dial (compound B) were isolated from the seeds of Alpinia nigra for the first time...
  14. Satou T, Murakami S, Matsuura M, Hayashi S, Koike K. Anxiolytic effect and tissue distribution of inhaled Alpinia zerumbet essential oil in mice. Nat Prod Commun. 2010;5:143-6 pubmed
    ..In this report, GC-MS analysis was used to observe the tissue distribution of the multiple components of Alpinia zerumbet (Pers.) B.L. Burtt. et Sm...
  15. Sirat H, Basar N, Jani N. Chemical compositions of the rhizome oils of two Alpinia species of Malaysia. Nat Prod Res. 2011;25:982-6 pubmed publisher
    The essential oils obtained by hydrodistillation of the rhizomes of Alpinia aquatica Rosc. syn. Alpinia melanocarpa and Alpinia malaccensis Roscoe were analysed by capillary gas chromatography and gas chromatography-mass spectrometry...
  16. Awang K, Ibrahim H, Rosmy Syamsir D, Mohtar M, Mat Ali R, Azah Mohamad Ali N. Chemical constituents and antimicrobial activity of the leaf and rhizome oils of Alpinia pahangensis Ridl., an endemic wild ginger from peninsular Malaysia. Chem Biodivers. 2011;8:668-73 pubmed publisher
    The essential oils from the leaves and rhizomes of Alpinia pahangensis Ridl., collected from Pahang, Peninsular Malaysia, were obtained by hydrodistillation, and their chemical compositions were determined by GC and GC/MS analyses...
  17. Yang H, Chen S, Chen C, Wang S, Hseu Y. Alpinia pricei rhizome extracts induce apoptosis of human carcinoma KB cells via a mitochondria-dependent apoptotic pathway. Food Chem Toxicol. 2008;46:3318-24 pubmed publisher
    b>Alpinia pricei Hayata (A. pricei) is well known in Taiwan as a traditional Chinese medicine. In this study, the ability of ethanol (70%) extracts of A...
  18. Yadav P, Liu Z, Rafi M. A diarylheptanoid from lesser galangal (Alpinia officinarum) inhibits proinflammatory mediators via inhibition of mitogen-activated protein kinase, p44/42, and transcription factor nuclear factor-kappa B. J Pharmacol Exp Ther. 2003;305:925-31 pubmed
    ..HMP) is a naturally occurring phytochemical found in lesser galangal (Alpinia officinarum)...
  19. Xia Y, Gao X, Li Q. Identification and expression of floral organ homeotic genes from Alpinia oblongifolia (Zingiberaceae). J Integr Plant Biol. 2009;51:155-66 pubmed publisher
    ..genes in monocots, we report the sequence characteristic and transcript expression of three new MADS-box genes in Alpinia oblongifolia Hayata. Sequence and phylogenetic analysis reveals that these genes are FUL-like and AP3-like...
  20. In L, Azmi M, Ibrahim H, Awang K, Nagoor N. 1'S-1'-acetoxyeugenol acetate: a novel phenylpropanoid from Alpinia conchigera enhances the apoptotic effects of paclitaxel in MCF-7 cells through NF-?B inactivation. Anticancer Drugs. 2011;22:424-34 pubmed publisher
    ..compound 1'S-1'-acetoxyeugenol acetate (AEA), extracted from rhizomes of the Malaysian ethnomedicinal plant Alpinia conchigera Griff. (Zingiberaceae), on MCF-7 human breast cancer cells were investigated for the first time...
  21. Lee M, Seo C, Lee J, Shin I, Kim S, Ha H, et al. Alpinia katsumadai H(AYATA) seed extract inhibit LPS-induced inflammation by induction of heme oxygenase-1 in RAW264.7 cells. Inflammation. 2012;35:746-57 pubmed publisher
    In the present study, we investigated the effects of Alpinia katsumadai H(AYATA) (Zingiberaceae) seed ethanolic extract (AKEE) and its three components on the production of inflammatory mediators and some potential underlying mechanisms ..
  22. Shi G, An L, Jiang B, Guan S, Bao Y. Alpinia protocatechuic acid protects against oxidative damage in vitro and reduces oxidative stress in vivo. Neurosci Lett. 2006;403:206-10 pubmed
    In this study, the neuroprotective effects of Alpinia protocatechuic acid (PCA), a phenolic compound isolated from the dried fruits of Alpinia Oxyphylla Miq. was found...
  23. Mustahil N, Sukari M, Abdul A, Ali N, Lian G. Evaluation of biological activities of Alpinia mutica Roxb. and its chemical constituents. Pak J Pharm Sci. 2013;26:391-5 pubmed
    Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6-dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with ?-sitosterol (5)...
  24. Kwon H, Kim H, Yoon S, Ryu Y, Chang J, Cho K, et al. In vitro inhibitory activity of Alpinia katsumadai extracts against influenza virus infection and hemagglutination. Virol J. 2010;7:307 pubmed publisher
    b>Alpinia katsumadai (AK) extracts and fractions were tested for in vitro antiviral activities against influenza virus type A, specially human A/PR/8/34 (H1N1) and avian A/Chicken/Korea/MS96/96 (H9N2), by means of time-of-addition ..
  25. Koo B, Lee W, Chang Y, Kim C. Protective effects of alpinae oxyphyllae fructus (Alpinia oxyphylla MIQ) water-extracts on neurons from ischemic damage and neuronal cell toxicity. Phytother Res. 2004;18:142-8 pubmed
    Alpinae Oxyphyllae Fructus (Alpinia oxyphylla MIQ) (Korean name Ik-Jj-In) is a medicinal plant used in Korea for the treatment of various symptoms accompanying hypertension and cerebrovascular disorders...
  26. Shin J, Joo Han M, Kim D. 3-Methylethergalangin isolated from Alpinia officinarum inhibits pancreatic lipase. Biol Pharm Bull. 2003;26:854-7 pubmed
    The pancreatic lipase inhibitory activity of the rhizome of Alpinia officinarum (AO) and its antihyperlipidemic activity were measured...
  27. An L, Guan S, Shi G, Bao Y, Duan Y, Jiang B. Protocatechuic acid from Alpinia oxyphylla against MPP+-induced neurotoxicity in PC12 cells. Food Chem Toxicol. 2006;44:436-43 pubmed
    An ethyl acetate extract of Alpinia oxyphylla was found to possess neuroprotective activity against 1-methyl-4-phenylpyridinium ion (MPP(+)) induced apotosis and oxidative stress in cultured PC12 cells...
  28. de Araújo F, Silva M, Moura B, de Oliveira G, Leal L, Vasconcelos S, et al. Central nervous system effects of the essential oil of the leaves of Alpinia zerumbet in mice. J Pharm Pharmacol. 2009;61:1521-7 pubmed publisher
    b>Alpinia zerumbet, known in Brazil as colônia, is popularly used as a diuretic, antihypertensive, anti-ulcerogenic and sedative. Based on this, we have investigated the central effects of the essential oil isolated from A. zerumbet leaves.
  29. Lee J, Jung H, Giang P, Jin X, Lee S, Son P, et al. Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera. J Pharmacol Exp Ther. 2006;316:271-8 pubmed
    ..we identified cardamomin, 2',4'-dihydroxy-6'-methoxychalcone, as an inhibitor of NF-kappaB activation from Alpinia conchigera Griff (Zingiberaceae)...
  30. Song J, Chen Z, Liao J. Isolation and characterization of a SEP- like gene from Alpinia hainanensis (Zingiberaceae). Mol Biol Rep. 2010;37:917-22 pubmed publisher
    A cDNA clone, AhSEP3 was isolated from the young inflorescences of Alpinia hainanensis. AhSEP3 cDNA is 891 bp long with an open reading frame of 726 bp that encodes a 241-amino acid protein...
  31. de Moura R, Emiliano A, de Carvalho L, Souza M, Guedes D, Tano T, et al. Antihypertensive and endothelium-dependent vasodilator effects of Alpinia zerumbet, a medicinal plant. J Cardiovasc Pharmacol. 2005;46:288-94 pubmed
    b>Alpinia zerumbet (K. Schum), a medicinal plant originated from West Asia, is used in the northeast and southeast of Brazil as infusions or decoctions as a diuretic, antihypertensive, and antiulcerogenic...
  32. An N, Zou Z, Tian Z, Luo X, Yang S, Xu L. Diarylheptanoids from the rhizomes of Alpinia officinarum and their anticancer activity. Fitoterapia. 2008;79:27-31 pubmed
    Two new diarylheptanoids (1, 2), together with two known analogs (3, 4), were isolated from the rhizomes of Alpinia officinarum...
  33. Lee S, Shin H, Hwang H, Kim J. Antioxidant activity of extracts from Alpinia katsumadai seed. Phytother Res. 2003;17:1041-7 pubmed
    b>Alpinia katsumadai (Zingiberaceae) has been widely used in traditional Chinese medicine to treat a variety of conditions such as emesis and gastric disorders...
  34. Kuo Y, Su Y, Tseng Y, Wang S, Wang H, Chueh P. Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. Free Radic Biol Med. 2010;49:214-26 pubmed publisher
    ..We have isolated the novel chalcone flavokawain B from Alpinia pricei Hayata, a plant native to Taiwan that is used in food and traditional Chinese medicine...
  35. Shui Guan -, Bao Y, Bo Jiang -, An L. Protective effect of protocatechuic acid from Alpinia oxyphylla on hydrogen peroxide-induced oxidative PC12 cell death. Eur J Pharmacol. 2006;538:73-9 pubmed
    The neuroprotective effects of protocatechuic acid (PCA), a phenolic compound isolated from the kernels of Alpinia oxyphylla, on hydrogen peroxide (H(2)O(2))-induced apoptosis and oxidative stress in cultured PC12 cells were investigated...
  36. Hanish Singh J, Alagarsamy V, Diwan P, Sathesh Kumar S, Nisha J, Narsimha Reddy Y. Neuroprotective effect of Alpinia galanga (L.) fractions on A?(25-35) induced amnesia in mice. J Ethnopharmacol. 2011;138:85-91 pubmed publisher
    The rhizomes of Alpinia galanga (L.) Willd (Zingiberaceae), a ginger substitute for flavouring food was traditionally used as nervine tonic and stimulant.
  37. Jung C, Jang S, Ahn J, Gwon S, Jeon T, Kim T, et al. Alpinia officinarum inhibits adipocyte differentiation and high-fat diet-induced obesity in mice through regulation of adipogenesis and lipogenesis. J Med Food. 2012;15:959-67 pubmed publisher
    Although Alpinia officinarum has been used in traditional medicine for the treatment of several conditions, such as abdominal pain, emesis, diarrhea, impaired renal function, and dysentery, little is known about its function in obesity...
  38. Eumkeb G, Sakdarat S, Siriwong S. Reversing ?-lactam antibiotic resistance of Staphylococcus aureus with galangin from Alpinia officinarum Hance and synergism with ceftazidime. Phytomedicine. 2010;18:40-5 pubmed publisher
    The purpose of this investigation was to extract and identify the bioactive phytochemicals from smaller galanga (Alpinia officinarum Hance)...
  39. Min H, Nam J, Yu E, Hong J, Seo E, Hwang E. Effect of naturally occurring hydroxychavicol acetate on the cytokine production in T helper cells. Int Immunopharmacol. 2009;9:448-54 pubmed publisher
    ..chavicol acetate analogues, acetoxychavicol acetate (ACA) and hydroxychavicol acetate (HCA) from the rhizomes of Alpinia galanga...
  40. Leal Cardoso J, Moreira M, da Cruz G, de Morais S, Lahlou M, Coelho de Souza A. Effects of essential oil of Alpinia zerumbet on the compound action potential of the rat sciatic nerve. Phytomedicine. 2004;11:549-53 pubmed
    b>Alpinia zerumbet, known popularly as "colônia" in Northeastern Brazil, is a medicinal plant that has been used widely in folk medicine as teas and infusions for the treatment of intestinal and cardiovascular diseases, ..
  41. Seo J, Cho S, Park S, Lee E, Lee J, Han S, et al. 1'-Acetoxychavicol acetate isolated from Alpinia galanga ameliorates ovalbumin-induced asthma in mice. PLoS ONE. 2013;8:e56447 pubmed publisher
    ..In this study we evaluated the effect of 1'-acetoxychavicol acetate (ACA) isolated from Alpinia galanga rhizomes in a mouse model of ovalbumin (OVA)-induced asthma...
  42. Tamura S, Shiomi A, Kaneko M, Ye Y, Yoshida M, Yoshikawa M, et al. New Rev-export inhibitor from Alpinia galanga and structure-activity relationship. Bioorg Med Chem Lett. 2009;19:2555-7 pubmed publisher
    ..disclosed 1'-acetoxychavicol acetate (ACA, 1) as a new inhibitor for nuclear export of Rev from the roots of Alpinia galanga...
  43. Wang C, Yuan H, Bao X, Lan M. In vitro antioxidant and cytotoxic properties of ethanol extract of Alpinia oxyphylla fruits. Pharm Biol. 2013;51:1419-25 pubmed publisher
    b>Alpinia oxyphylla Miquel (Zingiberaceae) is a traditional Chinese herbal medicine widely used for the treatment of intestinal disorders, urosis and diuresis...
  44. Kaushik D, Yadav J, Kaushik P, Sacher D, Rani R. Current pharmacological and phytochemical studies of the plant Alpinia galanga. Zhong Xi Yi Jie He Xue Bao. 2011;9:1061-5 pubmed
    ..b>Alpinia galanga (family Zingiberaceae) is commonly known as galangal and has been used for its emmenagogue, aphrodisiac, ..
  45. Lin R, Yen C, Chou T, Chiang F, Wang G, Tseng Y, et al. Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla. BMC Complement Altern Med. 2013;13:237 pubmed publisher
    b>Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities.
  46. Kaur A, Singh R, Dey C, Sharma S, Bhutani K, Singh I. Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd. Indian J Exp Biol. 2010;48:314-7 pubmed
    Hexane, chloroform and ethyl acetate extracts (100 microg/ml) of Alpinia galanga rhizomes exhibited significant activity in vitro against promastigotes of L. donovani...
  47. He Z, Ge W, Yue G, Lau C, He M, But P. Anti-angiogenic effects of the fruit of Alpinia oxyphylla. J Ethnopharmacol. 2010;132:443-9 pubmed publisher
    The fruit of Alpinia oxyphylla, an herb commonly used in East Asian medicine, is variously used for the treatment of cancer and inflammatory conditions, which may possibly be mediated through anti-angiogenesis...
  48. Banjerdpongchai R, Punyati P, Nakrob A, Pompimon W, Kongtawelert P. 4'-Hydroxycinnamaldehyde from Alpinia galanga (Linn.) induces human leukemic cell apoptosis via mitochondrial and endoplasmic reticulum stress pathways. Asian Pac J Cancer Prev. 2011;12:593-8 pubmed
    Rhizomes of Alpinia galanga (Linn.) or 'Kha' in Thai are used in food and as folk medicine in South and Southeast Asia...
  49. Chou Y, Wang S, Chen G, Lin Y, Chao P. The functional assessment of Alpinia pricei on metabolic syndrome induced by sucrose-containing drinking water in mice. Phytother Res. 2009;23:558-63 pubmed publisher
    This study was designed to test whether Alpinia pricei (AP), a member of the ginger family indigenous to Taiwan, reduced metabolic syndrome induced by sucrose-containing drinking water in C57BL/6J mice...
  50. Ratnasooriya W, Jayakody J. Effects of aqueous extract of Alpinia calcarata rhizomes on reproductive competence of male rats. Acta Biol Hung. 2006;57:23-35 pubmed
    This study examined the effects of rhizomes of Alpinia calcarata Roscoe (Zingiberaceae) on male sexual competence and fertility, using a hot water extract (HWE) and rats...
  51. Morikawa T, Ando S, Matsuda H, Kataoka S, Muraoka O, Yoshikawa M. Inhibitors of nitric oxide production from the rhizomes of Alpinia galanga: structures of new 8-9' linked neolignans and sesquineolignan. Chem Pharm Bull (Tokyo). 2005;53:625-30 pubmed
    The 80% aqueous acetone extract from the rhizomes of Alpinia galanga showed nitric oxide (NO) production inhibitory activities in mouse peritoneal macrophages...
  52. Morikawa T, Matsuda H, Toguchida I, Ueda K, Yoshikawa M. Absolute stereostructures of three new sesquiterpenes from the fruit of Alpinia oxyphylla with inhibitory effects on nitric oxide production and degranulation in RBL-2H3 cells. J Nat Prod. 2002;65:1468-74 pubmed
    The 80% aqueous acetone extract and the ethyl acetate-soluble portion from the dried fruit of Alpinia oxyphylla MIQUEL were found to show inhibitory effects on nitric oxide production in lipopolysaccharide-activated macrophages and ..
  53. de Araújo F, de Oliveira G, Gomes P, Soares M, Silva M, Carvalho A, et al. Inhibition of ketamine-induced hyperlocomotion in mice by the essential oil of Alpinia zerumbet: possible involvement of an antioxidant effect. J Pharm Pharmacol. 2011;63:1103-10 pubmed publisher
    The antipsychotic, hypnotic, myorelaxant and antioxidant effects of the essential oil of Alpinia zerumbet (EOAZ) were studied.
  54. Awang K, Azmi M, Aun L, Aziz A, Ibrahim H, Nagoor N. The apoptotic effect of 1's-1'-acetoxychavicol acetate from Alpinia conchigera on human cancer cells. Molecules. 2010;15:8048-59 pubmed publisher
    1'-(S)-1'-Acetoxychavicol acetate (ACA) isolated from the Malaysian ethno-medicinal plant Alpinia conchigera Griff. was investigated for its potential as an anticancer drug...
  55. Bendjeddou D, Lalaoui K, Satta D. Immunostimulating activity of the hot water-soluble polysaccharide extracts of Anacyclus pyrethrum, Alpinia galanga and Citrullus colocynthis. J Ethnopharmacol. 2003;88:155-60 pubmed
    ..Link. (family Compositae) Citrullus colocynthis (L.) Schrad. (family Cucurbitaceae) and Alpinia galanga (L.) Willd. (family Zingiberaceae) were tested for their immunostimulating activity in mice...
  56. Sukhirun N, Pluempanupat W, Bullangpoti V, Koul O. Bioefficacy of Alpinia galanga (Zingiberaceae) rhizome extracts, (E)-p-acetoxycinnamyl alcohol, and (E)-p-coumaryl alcohol ethyl ether against Bactrocera dorsalis (Diptera: Tephritidae) and the impact on detoxification enzyme activities. J Econ Entomol. 2011;104:1534-40 pubmed
    ..However, we evaluated four extracts of Alpinia galanga Wild Linn (Zingiberaceae) rhizomes against adult flies and found hexane and ethanol extracts to be most ..
  57. Grienke U, Schmidtke M, Kirchmair J, Pfarr K, Wutzler P, Durrwald R, et al. Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. J Med Chem. 2010;53:778-86 pubmed publisher
    ..In the search for new antiviral drug leads from nature, the seed extract of Alpinia katsumadai has been phytochemically investigated...
  58. Lee J, Kim K, Jeong S, Lee S, Park H, Kim N, et al. Anti-inflammatory, anti-nociceptive, and anti-psychiatric effects by the rhizomes of Alpinia officinarum on complete Freund's adjuvant-induced arthritis in rats. J Ethnopharmacol. 2009;126:258-64 pubmed publisher
    b>Alpinia officinarum Hance (Zingiberaceae) is an annual plant. Its rhizome has long been used as an anti-inflammatory, an analgesic, a stomachic and a carminative in traditional medicine.
  59. Panich U, Kongtaphan K, Onkoksoong T, Jaemsak K, Phadungrakwittaya R, Thaworn A, et al. Modulation of antioxidant defense by Alpinia galanga and Curcuma aromatica extracts correlates with their inhibition of UVA-induced melanogenesis. Cell Biol Toxicol. 2010;26:103-16 pubmed publisher
    ..Therefore, developing effective antimelanogenic agents is of importance. Alpinia galanga (AG) and Curcuma aromatica (CA) are traditional medicinal plants widely used for skin problems...
  60. Hua S, Luo J, Wang X, Wang J, Kong L. Two novel monoterpene-chalcone conjugates isolated from the seeds of Alpinia katsumadai. Bioorg Med Chem Lett. 2009;19:2728-30 pubmed publisher
    ..compounds isorubraine (2) and sumadain C (3), and a known compound rubraine (1) were isolated from the seeds of Alpinia katsumadai...
  61. Matsuda H, Ando S, Kato T, Morikawa T, Yoshikawa M. Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharide-activated macrophages and the structural requirements of diarylheptanoids for the activity. Bioorg Med Chem. 2006;14:138-42 pubmed
    The 80% aqueous acetone extract from the rhizomes of Alpinia officinarum, a Chinese medicinal herb, were found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated mouse peritoneal macrophages...
  62. Murakami S, Li W, Matsuura M, Satou T, Hayashi S, Koike K. Composition and seasonal variation of essential oil in Alpinia zerumbet from Okinawa Island. J Nat Med. 2009;63:204-8 pubmed publisher
    The composition of steam-distilled essential oils from the leaves of Alpinia zerumbet (Pers.) B. L. Burtt. et R. M. Sm. cultivated in Okinawa Island was investigated by GC-MS analysis...
  63. Chang N, Wu C, Wang S, Pei R, Lin C. Alpinia pricei Hayata rhizome extracts have suppressive and preventive potencies against hypercholesterolemia. Food Chem Toxicol. 2010;48:2350-6 pubmed publisher
    The aim of this study was to investigate the effects of 70% ethanol extracts of Alpinia pricei (APE) on lipid profiles and lipid peroxidation...
  64. Upadhyay A, Chompoo J, Kishimoto W, Makise T, Tawata S. HIV-1 integrase and neuraminidase inhibitors from Alpinia zerumbet. J Agric Food Chem. 2011;59:2857-62 pubmed publisher
    ..In this regard, the leaves and rhizomes of Alpinia zerumbet, a traditionally important economic plant in Okinawa, were investigated for activity against HIV-1 ..