veratrum

Summary

Summary: A plant genus of the family Melanthiaceae with roots that contain VERATRUM ALKALOIDS used as emetics, parasiticides, antihypertensives. The common name "black hellebore" is used for both Veratrum nigrum and HELLEBORUS NIGER.

Top Publications

  1. Keeler R. Early embryonic death in lambs induced by Veratrum californicum. Cornell Vet. 1990;80:203-7 pubmed
    ..Both field and laboratory observations have suggested the possibility of embryonic death from 14th day ingestion of Veratrum californicum by pregnant sheep...
  2. Lee S, Panter K, Gaffield W, Stegelmeier B. Development of an enzyme-linked immunosorbent assay for the veratrum plant teratogens: cyclopamine and jervine. J Agric Food Chem. 2003;51:582-6 pubmed
    b>Veratrum californicum was responsible for large losses of sheep grazing high mountain ranges in central Idaho in the 1950s...
  3. Tang J, Li H, Shen Y, Jin H, Yan S, Liu X, et al. Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum. Phytother Res. 2010;24:821-6 pubmed publisher
    ..3-angyloylzygadenine, 3-veratroyl zygadenine, 15-veratroylgermine, germine, veratrosine and pseudojervine - from Veratrum dahuricum, together with the ethanol extract and total alkaloids, were evaluated for their antitumor and ..
  4. Kleijn D, Treier U, Müller Schärer H. The importance of nitrogen and carbohydrate storage for plant growth of the alpine herb Veratrum album. New Phytol. 2005;166:565-75 pubmed
    We examined whether nitrogen (N) and carbohydrates reserves allow Veratrum album, an alpine forb, to start spring growth earlier than the neighbouring vegetation and to survive unpredictable disturbances resulting in loss of above-ground ..
  5. Gaillard Y, Pepin G. LC-EI-MS determination of veratridine and cevadine in two fatal cases of Veratrum album poisoning. J Anal Toxicol. 2001;25:481-5 pubmed
    ..the presence of a very large number of small blackish granules, which were later identified as seeds of a Veratrum species...
  6. Kikuchi R, Jae Hong P, Takahashi H, Maki M. Disjunct distribution of chloroplast DNA haplotypes in the understory perennial Veratrum album ssp. oxysepalum (Melanthiaceae) in Japan as a result of ancient introgression. New Phytol. 2010;188:879-91 pubmed publisher
    ..To investigate such signatures, we performed a phylogeographical study on the perennial plant Veratrum album ssp. oxysepalum, which may have hybridized long ago with another congeneric species, V. stamineum...
  7. Kim D, Kim J, Baek S, Seo J, Kho Y, Oh T, et al. Enhancement of tyrosinase inhibition of the extract of Veratrum patulum using cellulase. Biotechnol Bioeng. 2004;87:849-54 pubmed
    Inhibitors of melanin biosynthesis were screened by using three different methods. The extract of Veratrum patulum contains hydroxystilbene compounds that are potent tyrosinase inhibitors...
  8. Do H, Kim J, Kim J. Comparative genomics of four Liliales families inferred from the complete chloroplast genome sequence of Veratrum patulum O. Loes. (Melanthiaceae). Gene. 2013;530:229-35 pubmed publisher
    ..In this study, the nucleotide sequence of the chloroplast genome (cpDNA) of Veratrum patulum Loes. (Melanthiaceae, Liliales) was analyzed completely...
  9. Tang J, Li H, Shen Y, Jin H, Yan S, Liu R, et al. Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum. Phytother Res. 2008;22:1093-6 pubmed publisher
    ..fraction, CHCl(3) fraction, ethyl acetate fraction, n-butanol fraction and total alkaloids) from the rhizomes of Veratrum dahuricum, and six compounds (veratramine (1), jervine (2), germine (3), veramitaline (4), veratrosine (5) and ..

More Information

Publications75

  1. Ivanova A, Serly J, Christov V, Stamboliyska B, Molnar J. Alkaloids derived from genus Veratrum and Peganum of Mongolian origin as multidrug resistance inhibitors of cancer cells. Fitoterapia. 2011;82:570-5 pubmed publisher
    ..The ability of six alkaloids from Veratrum lobelianum, one from Veratrum nigrum and three from Peganum nigellastrum to modify transport activity of MDR1 was ..
  2. Welch K, Panter K, Lee S, Gardner D, Stegelmeier B, Cook D. Cyclopamine-induced synophthalmia in sheep: defining a critical window and toxicokinetic evaluation. J Appl Toxicol. 2009;29:414-21 pubmed publisher
    Cyclopamine, a steroidal alkaloid, from the plant Veratrum californicum is teratogenic, causing a range of different birth defects...
  3. Chen J. I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs. Nat Prod Rep. 2016;33:595-601 pubmed publisher
    ..In this highlight I describe how these mysterious incidents were traced to the grazing of Veratrum californicum wildflowers by pregnant ewes, leading to the discovery of cyclopamine () as a plant-derived ..
  4. Schmiderer C, Ruzicka J, Novak J. DNA-based identification of Peucedanum ostruthium specimens and detection of common adulterants by high-resolution melting curve analysis. Mol Cell Probes. 2015;29:343-350 pubmed publisher
    ..A multiplex PCR/HRM was developed to detect adulterations with Gentiana spp., Aconitum napellus and Veratrum album.
  5. Maepa M, Razwinani M, Motaung S. Effects of resveratrol on collagen type II protein in the superficial and middle zone chondrocytes of porcine articular cartilage. J Ethnopharmacol. 2016;178:25-33 pubmed publisher
    Resveratrol (RSV) was first isolated in 1940 from the roots of white hellebore (Veratrum grandiflorum (Maxim. ex Miq) O. Loes) and in 1963 from the roots of Japanese knotweed (Polygonum cuspidatum Siebold & Zucc.)...
  6. Lyu C, Zhang Y, Zhou W, Zhang S, Kou F, Wei H, et al. Gender-Dependent Pharmacokinetics of Veratramine in Rats: In Vivo and In Vitro Evidence. AAPS J. 2016;18:432-44 pubmed publisher
    Veratramine, a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. Our previous study indicated that veratramine had severe toxicity toward male rats...
  7. Kikkawa H, Tsuge K, Kubota S, Aragane M, Ohta H, Sugita R. Species identification of white false hellebore (Veratrum album subsp. oxysepalum) using real-time PCR. Forensic Sci Int. 2017;275:160-166 pubmed publisher
    ..False helleborine (Veratrum album) is one of the most common plants involved in such accidents...
  8. Gao L, Chen F, Li X, Xu S, Huang W, Ye Y. Three new alkaloids from Veratrum grandiflorum Loes with inhibition activities on Hedgehog pathway. Bioorg Med Chem Lett. 2016;26:4735-4738 pubmed publisher
    ..new steroidal alkaloids 1-3, together with four known compounds 4-7, were isolated from the ethanol extract of Veratrum grandiflorum Loes. Their structures were elucidated by NMR (1D and 2D NMR) and MS spectroscopic data...
  9. Du Y, Zheng Z, Yu Y, Wu Z, Liang D, Li P, et al. Rapid discovery of cyclopamine analogs from Fritillaria and Veratrum plants using LC-Q-TOF-MS and LC-QqQ-MS. J Pharm Biomed Anal. 2017;142:201-209 pubmed publisher
    ..spectrometry (LC-QqQ-MS) for rapid screening and targeted isolation of cyclopamine analogs in Fritillaria and Veratrum plants...
  10. Wei Z, Dong X, Zhang H, Gao S, Shi W, Yang F, et al. Hydrophilic interaction and reversed-phase ultra-performance liquid chromatography TOF-MS for metabolomic analysis of Veratrum nigrum-induced cardiotoxicity. Biomed Chromatogr. 2017;31: pubmed publisher
    The acute cardiotoxicity induced by Veratrum nigrum (VN) is explored by analyzing heart tissue metabolic profiles in mouse models and applying reversed-phase liquid chromatography mass spectrometry and hydrophilic interaction liquid ..
  11. Zhao W, Guo Y, Wang S, Shao T, Tezuka Y, Kikuchi T. [Chemical research on stilbenes from Veratrum macckii Reg]. Zhongguo Zhong Yao Za Zhi. 1998;23:619-20, 640 pubmed
    To study the components in rhizome of Veratrum macckii. Column chromatography and preparative thin layer chromatography with silica gel were employed for the isolation and purification of constituents...
  12. Turner M, Cruz R, Mattos J, Baughman N, Elwell J, Fothergill J, et al. Cyclopamine bioactivity by extraction method from Veratrum californicum. Bioorg Med Chem. 2016;24:3752-7 pubmed publisher
    b>Veratrum californicum, commonly referred to as corn lily or Californian false hellebore, grows in high mountain meadows and produces the steroidal alkaloid cyclopamine, a potent inhibitor of the Hedgehog (Hh) signaling pathway...
  13. Christov V, Mikhova B, Selenge D. (-)-Veranigrine, a new steroidal alkaloid from Veratrum nigrum L. Fitoterapia. 2009;80:25-7 pubmed publisher
    A new steroidal alkaloid, (-)-veranigrine (1) was isolated from the roots and rhizomes of Veratrum nigrum L. By means of spectroscopic methods its structure was established as (20S, 25S)-iminocholesta-5,22(N)-diene-1beta,3beta-diol.
  14. White S, Adelberg J, Naylor Adelberg J, Mann D, Song J, Sun Y. Micropropagation, Acclimatization, and Greenhouse Culture of Veratrum californicum. Methods Mol Biol. 2016;1391:187-99 pubmed publisher
    Micropropagation and production of Veratrum californicum is most successful when using a premixed Murishage and Skoog basal medium with vitamins and a 5-week subculture cycle at 16 °C for multiplication...
  15. Li Q, Yang K, Zhao Y, Qin X, Yang X, Liu L, et al. Potent anti-inflammatory and analgesic steroidal alkaloids from Veratrum taliense. J Ethnopharmacol. 2016;179:274-9 pubmed publisher
    Pimacao" (the roots and rhizomes of Veratrum taliense Loes.) has been used as traditional folk medicine in Yunnan province (PR China) for the treatment of pain, swelling, and inflammation...
  16. Wang Y, Wang Y, Liang Q, Ma Z, Xiao C, Tan H, et al. [Study on toxicity of uniform design-based compatible use of Veratrum nigrum and asarum]. Zhongguo Zhong Yao Za Zhi. 2012;37:2139-42 pubmed
    The compatible use of Veratrum nigrum with asarum, is one of the eighteen incompatible pairs. To research the toxic regularity of the compatible use of V...
  17. Keeler R, Stuart L. The nature of congenital limb defects induced in lambs by maternal ingestion of Veratrum californicum. J Toxicol Clin Toxicol. 1987;25:273-86 pubmed
    Groups of ewes were gavaged Veratrum californicum root-rhizome material over various 3 day periods during early gestation and their late-term fetuses examined...
  18. Liao W, Zhang D. Increased maleness at flowering stage and femaleness at fruiting stage with size in an andromonoecious perennial, Veratrum nigrum. J Integr Plant Biol. 2008;50:1024-30 pubmed publisher
    ..investment between female and male reproduction, and their size-dependence in a perennial andromonoecious herb, Veratrum nigrum L...
  19. Wilson S, Strand M, Krapp A, Rise F, Herstad G, Malterud K, et al. Hedgehog antagonists cyclopamine and dihydroveratramine can be mistaken for each other in Veratrum album. J Pharm Biomed Anal. 2010;53:497-502 pubmed publisher
    A toxic plant, Veratrum album (ssp...
  20. Gilotta I, Brvar M. Accidental poisoning with Veratrum album mistaken for wild garlic (Allium ursinum). Clin Toxicol (Phila). 2010;48:949-52 pubmed publisher
    b>Veratrum album (white or false hellebore) is a poisonous plant containing steroidal alkaloids that cause nausea, vomiting, headache, visual disturbances, paresthesia, dizziness, bradycardia, atrioventricular block, hypotension, and ..
  21. Rauber Lüthy C, Halbsguth U, Kupferschmidt H, König N, Mégevand C, Zihlmann K, et al. Low-dose exposure to Veratrum album in children causes mild effects--a case series. Clin Toxicol (Phila). 2010;48:234-7 pubmed publisher
    White or false hellebore (Veratrum album) has a toxicological relevance because of the potential for misidentification of this plant as yellow gentian (Gentiana lutea).
  22. Li H, Tang J, Liu R, Lin M, Wang B, Lv Y, et al. Characterization and identification of steroidal alkaloids in the Chinese herb Veratrum nigrum L. by high-performance liquid chromatography/electrospray ionization with multi-stage mass spectrometry. Rapid Commun Mass Spectrom. 2007;21:869-79 pubmed
    ..4 protoverine-type alkaloids, 10 germine-type alkaloids and 3 zygadenin-type alkaloids) from the Chinese herb Veratrum nigrum L...
  23. Iler A, Inouye D. Effects of climate change on mast-flowering cues in a clonal montane herb, Veratrum tenuipetalum (Melanthiaceae). Am J Bot. 2013;100:519-25 pubmed publisher
    ..Climate change may therefore alter the frequency of masting, in turn affecting species in the community that use pulsed resources. •..
  24. Koo N, Cho D, Kim Y, Choi H, Kim K. Effects of resveratrol on mast cell degranulation and tyrosine phosphorylation of the signaling components of the IgE receptor. Planta Med. 2006;72:659-61 pubmed
    ..These results suggest that FcepsilonRI-mediated tyrosine phosphorylation of PLCgamma1 and ERK could be potential cellular targets of resveratrol for the inhibition of mast cell degranulation...
  25. Alfaro de la Vega G, Juárez M, Inclan S. [Eclampsia: treatment with Veratrum viride, procaine, magnesium sulfate and dextrose. 1951]. Ginecol Obstet Mex. 2006;74:68-73 pubmed
  26. Adomnicăi M, Dobrescu G, Ionescu G, Costea I, Mungiu O, Teslariu E, et al. [The evaluation of the teratogenesis and embryotoxicity of the pharmaceutical product Boicil tablets. I. The effect of the pharmaceutical product Boicil tablets on fertilization and implantation in rats and mice]. Rev Med Chir Soc Med Nat Iasi. 1990;94:369-73 pubmed
    ..It was concluded that Boicil tablets is not teratogenic...
  27. Wang G, Rong M, Li Q, Liu Y, Long C, Meng P, et al. Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5. Toxins (Basel). 2015;8: pubmed publisher
    Several species of the genus Veratrum that produce steroid alkaloids are commonly used to treat pain and hypertension in China and Europe. However, Veratrum alkaloids (VAs) induce serious cardiovascular toxicity...
  28. Zhou J, Wang Y, Chen Z, Gao Y. [Modulation of activities and mRNA expression of cytochrome P450 isoenzymes in rat liver by Sophora flaveacens and coadministration with Veratrum nigrum]. Zhongguo Zhong Yao Za Zhi. 2010;35:1845-9 pubmed
    To study the modulatory effect of Sophora flaveacens and co-administration with Veratrum nigrum on the activity and mRNA expression of cytochrome P450 isoenzymes in rat liver.
  29. Mader E, Ruzicka J, Schmiderer C, Novak J. Quantitative high-resolution melting analysis for detecting adulterations. Anal Biochem. 2011;409:153-5 pubmed publisher
    ..tool in detecting admixtures, able to detect a ratio of 1:1000 with unknown species, and of 1:200,000 with Veratrum nigrum. The example proves the ability of HRM for quantification in multiplex PCR...
  30. Tanaka N, Suto S, Kobayashi J. Veramadines A and B, New Steroidal Alkaloids from Veratrum maackii var. japonicum. Chem Pharm Bull (Tokyo). 2011;59:909-12 pubmed
    ..alkaloids possessing a cevanine-type skeleton, veramadines A (1) and B (2), were isolated from the aerial parts of Veratrum maackii var. japonicum. The structures of 1 and 2 were elucidated on the basis of their spectroscopic data.
  31. Song Q, Wang S, Zhao W. Total steroidal alkaloids from Veratrum patulum L. Inhibit platelet aggregation, thrombi formation and decrease bleeding time in rats. J Ethnopharmacol. 2012;141:183-6 pubmed publisher
    b>Veratrum patulum L. (Liliaceae) is used as one source of the Chinese traditional drug "Lilu" which has been used in the treatment of aphasia arising from apoplexy, wind type dysentery, headache, etc. for thousands of years.
  32. Chandler C, Habig J, Fisher A, Ambrose K, Jiménez S, McDougal O. Improved extraction and complete mass spectral characterization of steroidal alkaloids from Veratrum californicum. Nat Prod Commun. 2013;8:1059-64 pubmed
    Four steroidal alkaloids extracted from the roots and rhizomes of Veratrum californicum were separated by high performance liquid chromatography (HPLC) and identified using high resolution electrospray ionization time of flight tandem ..
  33. Cong Y, Guo L, Yang J, Li L, Zhou Y, Chen J, et al. Steroidal alkaloids from Veratrum japonicum with genotoxicity on brain cell DNA of the cerebellum and cerebral cortex in mice. Planta Med. 2007;73:1588-91 pubmed
    ..1), together with three known steroidal alkaloids ( 2 - 4), has been isolated from the roots and rhizomes of Veratrum japonicum (Baker) Loes. f....
  34. Quatrehomme G, Bertrand F, Chauvet C, Ollier A. Intoxication from Veratrum album. Hum Exp Toxicol. 1993;12:111-5 pubmed
    Two new cases of Veratrum poisoning are described. Clinical symptoms occurred quickly, within 30 min. Vomiting, a fall in blood pressure and bradycardia were observed...
  35. Cong Y, Zhou Y, Chen J, Zeng Y, Wang J. Alkaloid profiling of crude and processed Veratrum nigrum L. through simultaneous determination of ten steroidal alkaloids by HPLC-ELSD. J Pharm Biomed Anal. 2008;48:573-8 pubmed publisher
    b>Veratrum nigrum L., a traditional Chinese herb, has been used for treatment of hypertension, blood-stroke, excessive phlegm, epilepsy, etc...
  36. Bogdan I, Nechifor A, Băşea I, Hruban E. [From Rumanian folk medicine: Non-specific stimulus therapy using transcutaneous implantation of hellebore (Helleborus purpurascens, Fam. Ranunculaceae) in agriculturally useful animals]. Dtsch Tierarztl Wochenschr. 1990;97:525-9 pubmed
    ..Pigs and sheep tolerate this procedure without any problems, so that the methods may be used in modern treatment...
  37. Schep L, Slaughter R, Vale J, Wheatley P. Was the death of Alexander the Great due to poisoning? Was it Veratrum album?. Clin Toxicol (Phila). 2014;52:72-7 pubmed publisher
    ..To investigate the death of Alexander the Great to determine if he died from natural causes or was poisoned and, if the latter, what was the most likely poison...
  38. Hovhannisyan A, Matz M, Gebhardt R. From teratogens to potential therapeutics: natural inhibitors of the Hedgehog signaling network come of age. Planta Med. 2009;75:1371-80 pubmed publisher
    Steroidal alkaloids from Veratrum californicum (Durand) are known to exert teratogenic effects (e.g...
  39. Ma R, Ritala A, Oksman Caldentey K, Rischer H. Development of in vitro techniques for the important medicinal plant Veratrum californicum. Planta Med. 2006;72:1142-8 pubmed
    b>VERATRUM CALIFORNICUM (Liliaceae) is an important monocotyledonous medicinal plant which is the only source of the anticancer compound cyclopamine...
  40. Cong Y, Wang J, Wang R, Zeng Y, Liu C, Li X. A study on the chemical constituents of Veratrum nigrum L. processed by rice vinegar. J Asian Nat Prod Res. 2008;10:619-24 pubmed publisher
    ..2), jervine (3), veramarine (4), and veratroylzygadenine (5), have been isolated from the roots and rhizomes of Veratrum nigrum L. processed by rice vinegar...
  41. Grobosch T, Binscheck T, Martens F, Lampe D. Accidental intoxication with Veratrum album. J Anal Toxicol. 2008;32:768-73 pubmed
    ..The initial suspicion of Veratrum poisoning could be confirmed by identifying protoveratrines A (ProA) and protoveratrine B (ProB) in a sample from ..
  42. Sun B, Hoshino J, Jermihov K, Marler L, Pezzuto J, Mesecar A, et al. Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010;18:5352-66 pubmed publisher
    ..The aromatase and quinone reductase inhibitors resulting from these studies have potential value in the treatment and prevention of cancer...
  43. Zhao L, Ou Z, Wang K, Fu H. [Steroidal alkaloids of from Veratrum dahuricum]. Zhongguo Zhong Yao Za Zhi. 2009;34:3039-42 pubmed
    To study the steroidal alkaloids in Veratrum dahuricum.
  44. Bechtel L, Lawrence D, Haverstick D, Powers J, Wyatt S, Croley T, et al. Ingestion of false hellebore plants can cross-react with a digoxin clinical chemistry assay. Clin Toxicol (Phila). 2010;48:435-42 pubmed publisher
    ..This patient presented with nausea, vomiting, bradycardia, and hypotension after ingesting Veratrum viride (false hellebore). The patient's serum specimen demonstrated a positive digoxin level (0...
  45. Fan Q, Gu D, He M, Liu H, Sheng T, Xie G, et al. Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling. Chin J Cancer. 2011;30:472-81 pubmed publisher
    ..Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein...
  46. Zhang S, Zhou J, Shou Q, Peng Y, Shen Z. [Determination of jervine and veratramine in Veratrum plants using high performance liquid chromatography coupled with evaporative light scattering detection]. Se Pu. 2008;26:56-9 pubmed
    ..evaporative light scattering detection (ELSD) was developed for the determination of jervine and veratramine in veratrum plants. The extraction method of total active alkaloids from the raw material was also established...
  47. Christov V, Mikhova B, Ivanova A, Serly J, Molnar J, Selenge D, et al. Steroidal alkaloids of Veratrum lobelianum Bernh. and Veratrum nigrum L. Z Naturforsch C. 2010;65:195-200 pubmed
    Twelve steroidal alkaloids were isolated from four populations of Veratrum lobelianum Bernh. and Veratrum nigrum L...
  48. Zhou X, Lin X, Xiong Y, Jiang L, Li W, Li J, et al. Chondroprotective effects of palmatine on osteoarthritis in vivo and in vitro: A possible mechanism of inhibiting the Wnt/β-catenin and Hedgehog signaling pathways. Int Immunopharmacol. 2016;34:129-138 pubmed publisher
    ..Pal may be useful in the treatment of OA, in which its effect is likely mediated via the Wnt/β-catenin and Hedgehog signaling pathways. ..
  49. Wang Y, Gao Y, Chai B, Chen P, Tan H, Zhao Y, et al. [Modulation of the activities and mRNA expression of cytochrome P450 isoenzymes in rat liver by Panax gingseng and coadministration with Veratrum nigrum]. Zhongguo Zhong Yao Za Zhi. 2004;29:366-70 pubmed
    To study the modulatory effect of Panax gingseng and coadministration with Veratrum nigrum on the activity and mRNA expression of cytochrome P450 isoenzymes in rat liver.
  50. Panter K, Welch K, Gardner D, Green B. Poisonous plants: effects on embryo and fetal development. Birth Defects Res C Embryo Today. 2013;99:223-34 pubmed publisher
    ..associated with poisonous plants, such as locoweeds, selenium accumulating plants, poison-hemlock, larkspurs, Veratrum, lupines, death camas, water hemlock, and others...
  51. Miller S, Yu T. Cyclopamine as a potential therapeutic agent for treatment of tumors related to hedgehog pathway mutations. Dermatol Surg. 2002;28:187 pubmed
  52. Van Wassenhoven M. Towards an evidence-based repertory: clinical evaluation of Veratrum album. Homeopathy. 2004;93:71-7 pubmed
    ..As an example of clinical verification the outcomes of patients prescribed Veratrum album are correlated against rubrics...
  53. Zagler B, Zelger A, Salvatore C, Pechlaner C, De Giorgi F, Wiedermann C. Dietary poisoning with Veratrum album--a report of two cases. Wien Klin Wochenschr. 2005;117:106-8 pubmed
    b>Veratrum album is a poisonous plant that can easily be mistaken for the yellow gentian, Gentiana lutea, used in beverages. Two adult men were brought to the emergency department six hours after drinking gentian spirit...
  54. McFerren M. Useful plants of dermatology. VIII. The false hellebore (Veratrum californicum). J Am Acad Dermatol. 2006;54:718-20 pubmed
    ..In recent years, cyclopamine, a steroidal alkaloid isolated from Veratrum californicum, has been instrumental in dissecting the sonic hedgehog pathway...
  55. Wang L, Li W, Liu Y. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie. 2008;63:606-10 pubmed
    Total alkaloids (VTA) and veratramine of Veratrum nigrum L. were tested for hypotensive effect using spontaneously hypertensive rats (SHR). Acute toxicities were also evaluated...
  56. Prince L, Stork C. Prolonged cardiotoxicity from poison lilly (Veratrum viride). Vet Hum Toxicol. 2000;42:282-5 pubmed
    ..At this time, the regional poison control center botanist identified a sample of the ingested material as Veratrum viride...
  57. Hao Y, Huang W, Liao M, Zhu Y, Liu H, Hao C, et al. The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice. Fitoterapia. 2013;86:84-91 pubmed publisher
    ..Resveratrol (Res) is one type of polyphenolic compound which was first identified from the roots of Veratrum grandinorum in 1940...
  58. Chen Y, Lin Y, Tan T, Tsai H. Effects of veratrine and paeoniflorin on isolated mouse vas deferens. Phytomedicine. 2002;9:296-301 pubmed
    ..8 x 10(-5) g/ml) and ryanodine (1 x 10(-5) M) did not potentiate the inhibition of paeoniflorin in the veratrine-induced contraction in both the epididymal and the prostatic portions of isolated mouse vas deferens...
  59. Jaffe A, Gephardt D, Courtemanche L. Poisoning due to ingestion of Veratrum viride (false hellebore). J Emerg Med. 1990;8:161-7 pubmed
    We present six cases of poisoning due to ingestion of Veratrum viride (false hellebore) and review the physiology of veratrum alkaloids...
  60. Dyer S. Plant exposures: wilderness medicine. Emerg Med Clin North Am. 2004;22:299-313, vii pubmed
    ..This article discusses poisonous plants, the symptoms that might arise if they are ingested, and the treatments that should be administered to patients...
  61. Aggarwal B, Bhardwaj A, Aggarwal R, Seeram N, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004;24:2783-840 pubmed
    ..trans-3,5,4'-trihydroxystilbene, was first isolated in 1940 as a constituent of the roots of white hellebore (Veratrum grandiflorum O. Loes), but has since been found in various plants, including grapes, berries and peanuts...
  62. Johnson L. Gitksan medicinal plants--cultural choice and efficacy. J Ethnobiol Ethnomed. 2006;2:29 pubmed
    ..I examine use of medicinal plants from a "biobehavioral" perspective to illuminate cultural selection of plants used for medicine by the Gitksan of northwestern British Columbia, Canada...
  63. Schep L, Schmierer D, Fountain J. Veratrum poisoning. Toxicol Rev. 2006;25:73-8 pubmed
    Several species of the Veratrum genus are associated with toxicity in humans and animals. The principal toxins are steroid alkaloids; some have a modified steroid template, whereas others differ in their esterified acid moieties...
  64. Hesse E, Rees M, Müller Schärer H. Life-history variation in contrasting habitats: flowering decisions in a clonal perennial herb (Veratrum album). Am Nat. 2008;172:196-213 pubmed publisher
    ..We conclude that habitat is an important aspect of the selective environment and a significant factor in predicting the ESSs...
  65. Wang L, Zhao D, Tao H, Liu Y. [Determination of vetatramine in Veratrum nigrum by HPLC-ELSD]. Zhongguo Zhong Yao Za Zhi. 2008;33:791-2 pubmed
    To develop an HPLC-ELSD method for determination of vetatramine. in Veratrum nigrum.
  66. Li H, Tang J, Liu R, Zhang C, Zhang W. Two new flavanone glycosides from Veratrum nigrum L. Nat Prod Res. 2009;23:122-6 pubmed publisher
    Two new flavanone glycosides have been isolated from the water soluble part of Veratrum nigrum L., belonging to the family Lilica...