fritillaria

Summary

Summary: A plant genus of the family LILIACEAE. Members of this genus produce imperialine, a steroidal alkaloid which acts at muscarinic receptors.

Top Publications

  1. Zhang G, Li J, Zhang P, Ruan H, Zhang Y, Pi H, et al. [HPLC fingerprint of Fritillaria hupehensis]. Yao Xue Xue Bao. 2005;40:850-3 pubmed
    To establish a fingerprint analysis method of Fritillaria hupehensis. fingerprint was performed by HPLC-ELSD. Hypersil ODS column was used; the mobile phase was composed of methanol (with 0...
  2. Xiao P. [A review on the study of hubeibeimu]. Zhongguo Zhong Yao Za Zhi. 2002;27:726-8 pubmed
    ..Modern research is in accordance with the traditional experiences of TCM, and Hubeibeimu has been recorded in the latest Chinese Pharmacopoeia (2000 ed.), which is worthy of further development. ..
  3. Kang D, Oh H, Cho D, Kwon E, Han J, Lee H. Effects of bulb of Fritillaria ussuriensis maxim. on angiotensin converting enzyme and vascular release of NO/cGMP in rats. J Ethnopharmacol. 2002;81:49-55 pubmed
    The present study was designed to investigate whether the Bulbus Fritillaria shows a hypotensive effect via the angiotensin converting enzyme (ACE) inhibition and elicit NO/cGMP release in rat aortic rings...
  4. Atta Ur Rahman -, Akhtar M, Choudhary M, Tsuda Y, Sener B, Khalid A, et al. New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities. Chem Pharm Bull (Tokyo). 2002;50:1013-6 pubmed
    ..along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis...
  5. Wang C, Li P, Ding J, Jin G, Yuan C. Identification of Fritillaria pallidiflora using diagnostic PCR and PCR-RFLP based on nuclear ribosomal DNA internal transcribed spacer sequences. Planta Med. 2005;71:384-6 pubmed
    b>Fritillaria pallidiflora Schrenk (Liliaceae) is a commonly used antitussive herb. There are 9 species of Fritillaria recorded as herbal drugs in the Chinese Pharmacopoeia. The other species are often marketed as F...
  6. Kang D, Sohn E, Lee Y, Lee A, Han J, Kim T, et al. Effects of bulbus Fritillaria water extract on blood pressure and renal functions in the L-NAME-induced hypertensive rats. J Ethnopharmacol. 2004;91:51-6 pubmed
    ..The present study was aimed at investigating whether Bulbus Fritillaria water extract (BFWE) ameliorates NG-nitro-L-arginine methylester (L-NAME)-induced hypertension...
  7. Yuan X, Shi J, Yang Y, Luan J, Gao J, Wang Y. Establishment of element fingerprint and multielement analysis of Fritillaria thunbergii by inductively coupled plasma optical emission spectrometry. Biol Trace Elem Res. 2010;135:304-13 pubmed publisher
    Element fingerprints were deciphered for Fritillaria thunbergii from Chinese ten major fritillaria-producing regions for the purpose of examining differences in element composition with region of origin and identifying elements' ..
  8. Cao X, Li J, Chen S, Li X, Xiao P, Chen S, et al. Simultaneous determination of nine nucleosides and nucleobases in different Fritillaria species by HPLC-diode array detector. J Sep Sci. 2010;33:1587-94 pubmed publisher
    ..uracil, cytidine, guanine, uridine, thymine, inosine, guanosine, thymidine and adenosine in 13 different Fritillaria species...
  9. Wang D, Wang S, Chen X, Xu X, Zhu J, Nie L, et al. Antitussive, expectorant and anti-inflammatory activities of four alkaloids isolated from Bulbus of Fritillaria wabuensis. J Ethnopharmacol. 2012;139:189-93 pubmed publisher
    Bulbus Fritillaria Cirrhosae (BFC), known by the Chinese name "Chuan-Bei-Mu", is used as an antitussive, antiasthmatic and expectorant drug for more than 2000 years in China, and Bulbus of Fritillaria wabuensis S. Y...

More Information

Publications123 found, 100 shown here

  1. Lin B, Ji H, Li P, Fang W, Jiang Y. Inhibitors of acetylcholine esterase in vitro--screening of steroidal alkaloids from Fritillaria species. Planta Med. 2006;72:814-8 pubmed
    18 alkaloids were successfully isolated from five Fritillaria species and 5 derivatives were synthesized. Their effects on the bioactivity of human whole blood cholinesterase (ChE) were assessed...
  2. Ambrozová K, Mandáková T, Bures P, Neumann P, Leitch I, Koblizkova A, et al. Diverse retrotransposon families and an AT-rich satellite DNA revealed in giant genomes of Fritillaria lilies. Ann Bot. 2011;107:255-68 pubmed publisher
    The genus Fritillaria (Liliaceae) comprises species with extremely large genomes (1C = 30 000-127 000 Mb) and a bicontinental distribution...
  3. Zych M, Stpiczynska M. Neither protogynous nor obligatory out-crossed: pollination biology and breeding system of the European Red List Fritillaria meleagris L. (Liliaceae). Plant Biol (Stuttg). 2012;14:285-94 pubmed publisher
    For 4 years we studied pollination biology and breeding system of the critically endangered, Red List plant Fritillaria meleagris L. (Liliaceae), in the larger of the two remaining populations of the plant in SE Poland...
  4. Liu H, Li F, Luo Y, Zhu W, Yan D, Huang X. [Diterpenoids from bulbus of Fritillaria monanth]. Yao Xue Xue Bao. 2007;42:1152-4 pubmed
    To study the chemical constituents of Fritillaria monanth Migo, the constituents were separated and purified by column chromatography on silica gel, and the structures were identified by NMR, MS spectral data...
  5. Wang Y, He Z, Sun Y, Ma L, Liu Y, Lin K. [Study on the production of alkaloid by cell mass suspension culture of Fritillaria cirrhosa]. Zhong Yao Cai. 2011;34:183-6 pubmed
    Set up Fritillaria cirrhosa cell mass suspension culture system to rapidly screen the best culture conditions for cell mass proliferation and hormone combination...
  6. Wang Q, Tong L, Yao L, Zhang P, Xu L. Fingerprinting of traditional Chinese medicines on the C18-Diol mixed-mode column in online or offline two-dimensional liquid chromatography on the single column modes. J Pharm Biomed Anal. 2016;125:205-11 pubmed publisher
    ..The separation of total alkaloids extracted from Fritillaria hupehensis was compared on the C18-Diol and conventional C18 column with the greater resolving power and better ..
  7. Ma L, Hatlen A, Kelly L, Becher H, Wang W, Kovarik A, et al. Angiosperms Are Unique among Land Plant Lineages in the Occurrence of Key Genes in the RNA-Directed DNA Methylation (RdDM) Pathway. Genome Biol Evol. 2015;7:2648-62 pubmed publisher
    ..SHH1 (SAWADEE homeodomain homolog 1), KTF1, and SUVR2, although we failed to find the latter three proteins in Fritillaria persica, a species with a giant genome. Small RNAs of 24 nt in length were abundant only in angiosperms...
  8. Wang S, Xu X, Li T. [Determination and contrastion of alkaloids and saponins in Bulbus Fritillariae Cirrhosae and in other beimus]. Zhongguo Zhong Yao Za Zhi. 2002;27:342-4 pubmed
    ..The contents of alkaloids and saponins in 4 species of Bulbus Fritillariae Cirrhosae (each specie including 3 samples) Zhe Beimu, Yi Beimu and Pin Beimu (each specie including 2 samples) were determined. ..
  9. Du Y, Zheng Z, Yu Y, Wu Z, Liang D, Li P, et al. Rapid discovery of cyclopamine analogs from Fritillaria and Veratrum plants using LC-Q-TOF-MS and LC-QqQ-MS. J Pharm Biomed Anal. 2017;142:201-209 pubmed publisher
    ..mass spectrometry (LC-QqQ-MS) for rapid screening and targeted isolation of cyclopamine analogs in Fritillaria and Veratrum plants...
  10. Pae H, Oh H, Choi B, Oh G, Paik S, Jeong S, et al. Differentiation-inducing effects of verticinone, an isosteroidal alkaloid isolated from the bulbus of Fritillaria ussuriensis, on human promyelocytic leukemia HL-60 cells. Biol Pharm Bull. 2002;25:1409-11 pubmed
    ..Verticinone, one of the major isosteroidal alkaloids from the bulbus of Fritillaria ussuriensis, was found to inhibit the growth of HL-60 cells by inducing these cells to differentiate toward ..
  11. Jiang Y, Li H, Li P, Cai Z, Ye W. Steroidal alkaloids from the bulbs of Fritillaria puqiensis. J Nat Prod. 2005;68:264-7 pubmed
    ..and puqietinonoside (4), along with a known steroidal alkaloid, puqietinone, were isolated from the bulbs of Fritillaria puqiensis. The structures of these compounds were elucidated on the basis of spectroscopic analysis...
  12. Lei Y, Yang F, Tang L, Chen K, Zhang G. Identification of Chinese Herbs Using a Sequencing-Free Nanostructured Electrochemical DNA Biosensor. Sensors (Basel). 2015;15:29882-92 pubmed publisher
    ..sequencing-free electrochemical biosensor, which enables easy differentiation between two closely related Fritillaria species...
  13. Bi Y, Zhang M, Xue J, Dong R, Du Y, Zhang X. Chloroplast genomic resources for phylogeny and DNA barcoding: a case study on Fritillaria. Sci Rep. 2018;8:1184 pubmed publisher
    The genus Fritillaria comprises approximately 130 perennial herbaceous species. In the Pharmacopoeia of the People's Republic of China, the bulbs of 11 Fritillaria species are used in Chinese herbal medicines...
  14. Rønsted N, Law S, Thornton H, Fay M, Chase M. Molecular phylogenetic evidence for the monophyly of Fritillaria and Lilium (Liliaceae; Liliales) and the infrageneric classification of Fritillaria. Mol Phylogenet Evol. 2005;35:509-27 pubmed
    We present phylogenetic analyses of 37 taxa of Fritillaria (Liliaceae), 15 species of Lilium, and several outgroup taxa from Liliaceae s.s...
  15. Wu J, Zhan X, Zou Y, Chen S, Lu G, Lai F. [Investigation of organophosphorous insecticides residue in Chinese crude drugs]. Zhongguo Zhong Yao Za Zhi. 2007;32:798-800 pubmed
    ..It provides a method for the risk assessment of organophosphorous pesticide in Chinese crude drugs. ..
  16. Xu J, Liu C, Guo P, Guo Y, Jin D, Song X, et al. Neuroprotective labdane diterpenes from Fritillaria ebeiensis. Fitoterapia. 2011;82:772-6 pubmed publisher
    By bioactivity-guided isolation, two labdane diterpenes (1 and 2) have been isolated from the bulbs of Fritillaria ebeiensis...
  17. Zhang P, Li J, Zhang G, Pi H, Zhang Y, Ruan H, et al. Analysis of hupehenine in the total alkaloids from Fritillaria hupehensis by HPLC-ELSD. J Huazhong Univ Sci Technolog Med Sci. 2008;28:118-20 pubmed publisher
    ..detection (ELSD) has been developed for the quantitative analysis of hupehenine in the total alkaloids from Fritillaria hupehensis...
  18. Wang D, Yang J, Du Q, Li H, Wang S. The total alkaloid fraction of bulbs of Fritillaria cirrhosa displays anti-inflammatory activity and attenuates acute lung injury. J Ethnopharmacol. 2016;193:150-158 pubmed publisher
    Bulb of Fritillaria cirrhosa D...
  19. Guo X, Ni J, Xue J, Wang X. Extract of bulbus Fritillaria cirrhosa perturbs spindle assembly checkpoint, induces mitotic aberrations and genomic instability in human colon epithelial cell line. Exp Toxicol Pathol. 2017;69:163-171 pubmed publisher
    Bulbus Fritillaria cirrhosa D. Don (BFC) has been used in China as a folk medicine for the treatment of cough and asthma for more than 2000 years...
  20. Petrić M, Subotić A, Jevremović S, Trifunović Momčilov M, Tadić V, Grujić M, et al. Esterase and peroxidase isoforms in different stages of morphogenesis in Fritillaria meleagris L. in bulb-scale culture. C R Biol. 2015;338:793-802 pubmed publisher
    ..We investigated esterase and peroxidase isoforms detected in bulb scale, during Fritillaria meleagris morphogenesis...
  21. Xue Y, Gu H. [Determination of peimine and peiminine in Fritillaria thunbergii by HPLC-ELSD]. Yao Xue Xue Bao. 2005;40:550-2 pubmed
    To determine peimine and peiminine in Fritillaria drug simultaneously by RP-HPLC-ELSD. HPLC was carried out with a Waters Alliance, Model 2690, equipped with XTerra RP18 column (150 mm x 3...
  22. Liu C, Chang J, Zhang L, Zhang J, Li S. Purification and antioxidant activity of a polysaccharide from bulbs of Fritillaria ussuriensis Maxim. Int J Biol Macromol. 2012;50:1075-80 pubmed publisher
    A water-soluble polysaccharide (FUP-1) was obtained from Fritillaria ussuriensis Maxim through warm water extraction, ethanol precipitation, anion-exchange and gel-permeation chromatography...
  23. Liu L, You W, Zheng L, Chen F, Jia Z. Determination of peimine and peiminine in Bulbus Fritillariae Thunbergii by capillary electrophoresis by indirect UV detection using N-(1-naphthyl)ethylenediamine dihydrochloride as probe. Electrophoresis. 2012;33:2152-8 pubmed publisher
    ..9995-0.9996) between the peak area of each analyte and the concentration. The method developed was successfully applied to quantify peimine and peiminine in chloroform extracts of the ground Bulbus Fritillariae Thunbergii. ..
  24. Zhu Y, Chen F, Xue J, Zhang A, Sheng W, Song Y. [Study on preservation of Fritillaria anhuiensis by vitrification in vitro]. Zhongguo Zhong Yao Za Zhi. 2011;36:2462-4 pubmed
    To establish cryopreservation system of shoot-tips from Fritillaria anhuiensis. Taking vitrification as system of cryopreservation, the shoot tips with length 2-3 mm were precultured in MS medium enriched with 0...
  25. Dong X, Wang S, Li X, Song F, Liu Z, Liu S. [Determination of content changes of three diester-diterpenoid alkaloids in compatibility of radix aconiti laterlis preparata and Rhizoma pinelliae, Fructus trichosanthis, Bulbus fritillariae, Radix ampelopsis, Rhizoma bletillae by HPLC]. Zhong Yao Cai. 2011;34:1891-4 pubmed
  26. Li P, Zeng L, Li S, Bi Z, Lin G. Simultaneous determination of the major isosteroidal alkaloids and their glucosides in the bulbs of Fritillaria by high performance liquid chromatography coupled with evaporative light scattering detection. Yao Xue Xue Bao. 2004;39:56-9 pubmed
    ..simultaneous determination of five major bioactive isosteroidal alkaloids and gluco-alkaloids in the bulbs of Fritillaria namely peimissine, imperialine, sinpeinine A, imperialine-3 beta-glucoside and yibeinoside A...
  27. Yu H, Jiang Y, Li P, Li S, Wang Y. [Study on analytical method for alkaloids in Bulbus Fritillariae cirrhosae]. Zhongguo Zhong Yao Za Zhi. 2005;30:572-5 pubmed
    ..The developed method is simple, rapid, accurate and sensitive for determining the content of peimisine in crude Bulbus Fritillariae Cirrhosae. ..
  28. Lakey -, Dorji K. Ecological status of high altitude medicinal plants and their sustainability: Lingshi, Bhutan. BMC Ecol. 2016;16:45 pubmed
    ..were critically low in plant density with less than a plant per m2 while Delphinium glaciale, Fritillaria delavayi and Aconitum orochryseum were confined to narrow altitude range...
  29. Kan L, Zhao W, Pan L, Xu J, Chen Q, Xu K, et al. Peimine inhibits hERG potassium channels through the channel inactivation states. Biomed Pharmacother. 2017;89:838-844 pubmed publisher
    b>Fritillaria is a Chinese traditional herb. It has a long history and many medicinal usages including antitussive, anti-inflammatory and pain relieving actions. It is also used as food. However, its cardiac safety has not been tested...
  30. Chen J, Zheng H, Shi Y, Adams M, Wei C, Lin L, et al. Detection and characterisation of a second potyvirus from Thunberg fritillary in China. Arch Virol. 2006;151:439-47 pubmed
    Plants of Thunberg fritillary (Fritillaria thunbergii Miq.) from Zhejiang Province, were found to be co-infected with two distinct potyviruses. One was an isolate of the recently reported Thunberg fritillary mosaic virus (TFMV; Wei et al...
  31. de Carvalho P, Bonecker S, Nassar C. Analysis of the Appendicularia class (subphylum Urochordata) as a possible tool for biomonitoring four estuaries of the tropical region. Environ Monit Assess. 2016;188:606 pubmed
    ..were Oikopleura longicauda (Vogt, 1854), Oikopleura dioica Fol, 1872, Oikopleura fusiformis Fol, 1872, and Fritillaria haplostoma Fol, 1872. The density of appendicularians and O...
  32. Pi H, Ruan H, Zhan Y, Wu J. Two new steroidal alkaloids from bulbs of Fritillaria lichuanensis. J Asian Nat Prod Res. 2006;8:253-7 pubmed
    ..Li et C.P. Yang. Their structures were determined to be (20S,25R)-5alpha, 14alpha-cevanine-3beta, 6beta-diol (1) and (20S,25S)-5alpha,14alpha-cevanine-3beta,6beta-diol-N-oxide (2) by means of spectral analysis and chemical evidence. ..
  33. An J, Zhou J, Li H, Jiang Y, Li P. Puqienine E: an angiotensin converting enzyme inhibitory steroidal alkaloid from Fritillaria puqiensis. Fitoterapia. 2010;81:149-52 pubmed publisher
    ..A, puqienine B, puqienine C, puqienine D, puqienine E, puqietinone, puqiedine and peimisine were isolated from Fritillaria puqiensis G. D. Yu et. G. Y...
  34. Duan B, Huang L, Chen S. Chemical fingerprint analysis of Fritillaria delavayi Franch. by high-performance liquid chromatography. J Sep Sci. 2012;35:513-8 pubmed publisher
    Bulbus of Fritillaria delavayi Franch. is the most commonly used antitussive and apophlegmatic in China and commonly prepared by water decoction...
  35. Wang C, Li P, Ding J, Peng X, Yuan C. Simultaneous identification of Bulbus Fritillariae cirrhosae using PCR-RFLP analysis. Phytomedicine. 2007;14:628-32 pubmed
    Bulbus Fritillariae (BF) is the most commonly used antitussive herb in China. There are nine species of Fritillaria recorded as the drug BF in the Chinese Pharmacopoeia...
  36. Liang J, Cao X, Li J, Ren H, Wu S. [Analysis of volatile components of flowers of Fritillaria thunbergii by GC-TOF-MS]. Zhongguo Zhong Yao Za Zhi. 2011;36:2689-92 pubmed
    To determine the structures and contents of the volatile components of flowers of Fritillaria thunbergii, and investigate the effects of operation modes on its volatile components...
  37. Mohammat A, Yili A, Aisa H. Rapid Quantification and Quantitation of Alkaloids in Xinjiang Fritillaria by Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. Molecules. 2017;22: pubmed publisher
    The Fritillaria genus, including different kinds of medicinal and edible plants belonging to the Liliaceae family which have the function of treating and relieving a cough and eliminating phlegm, is widely planted in Xinjiang (..
  38. Tsoi P, Woo H, Wong M, Chen S, Fong W, Xiao P, et al. Genotyping and species identification of Fritillaria by DNA chips. Yao Xue Xue Bao. 2003;38:185-90 pubmed
    To investigate the genetic polymorphism of several species of Fritillaria and to develop a DNA chip for the genotyping and identification of the origin of various species of Fritillaria at molecular level...
  39. Li H, Jiang Y, Li P, Ye W. Puqienine F, a novel veratramine alkaloid from the bulbs of Fritillaria puqiensis. Chem Pharm Bull (Tokyo). 2006;54:722-4 pubmed
    ..veratramine alkaloid, called puqienine F (1) and possessing a 12,16-epoxy ring, was isolated from the bulbs of Fritillaria puqiensis G. D. Yu et G. Y. Chen (Liliaceae)...
  40. Kang L, Zhou J, Shen Z. A new diterpenoid from Fritillaria anhuiensis. Yao Xue Xue Bao. 2007;42:58-60 pubmed
    The aim of this study was to look for the chemical constituents of the bulbs of Fritillaria anhuiensis S. C. Chen et S. E. Yin. The bulbs of Fritillaria anhuiensis were extracted with 95% EtOH at reflux...
  41. Li K, Wu W, Zheng Y, Dai Y, Xiang L, Liao K. [Genetic diversity of Fritillaria from Sichuan province based on ISSR]. Zhongguo Zhong Yao Za Zhi. 2009;34:2149-54 pubmed
    To provide more proofs for expounding the genetic relationships among the (varietal) species in genus Fritillaria from Sichuan province...
  42. Li Y, Li Y, Lin J, Xu Y, Yan F, Tang L, et al. Identification of bulb from Fritillaria cirrhosa by PCR with specific primers. Planta Med. 2003;69:186-8 pubmed
    Bulb of Fritillaria cirrhosa is an important traditional Chinese herbal medicine. According to the Chinese Pharmacopoeia (1995), it is commonly used as an antitussive and expectorant...
  43. Xue J, Zhang A, Geng M, Ma L. [Study on bulblet induction of Fritillaria anhuiensis in vitro]. Zhongguo Zhong Yao Za Zhi. 2008;33:2603-6 pubmed
    To study the optimal condition for bulb induction of Fritillaria anhuiensis in vitro...
  44. Wang D, Zhu J, Wang S, Wang X, Ou Y, Wei D, et al. Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus Fritillariae Cirrhosae. Fitoterapia. 2011;82:1290-4 pubmed publisher
    ..These results confirmed that the four alkaloids imperialine, chuanbeinone, verticinone and verticine may be the active ingredients of the Bulbus F. Cirrhosae (BFC). ..
  45. Yang Z, Duan D. A new alkaloid from Fritillaria ussuriensis Maxim. Fitoterapia. 2012;83:137-41 pubmed publisher
    ..cevane-3,6,16,20-tetrol (3), ebeiedinone (4), pingbeimine C (5) and verticine (6) were isolated from Fritillaria ussuriensis. The structure was elucidated on the basis of spectral analysis (IR, NMR and MS spectroscopy)...
  46. Xue Y, Wang F. [Simultaneous determination of peimine, peiminine and zhebeinine in Fritillaria thunbergii from different habitat by HPLC-ELSD]. Zhongguo Zhong Yao Za Zhi. 2007;32:1628-30 pubmed
    To determine peimine, peiminine and zhebeinine in Fritillaria thunbergii simultaneously by RP-HPLC-ELSD. The HPLC was carried out with a Waters Alliance, Model 2690, equipped with an Xterra RP18 column (3.9 mm x 150 mm, ...
  47. Zheng S, Tan H, Tao J, Shen Z. A convenient and efficient one-pot conversion of peimisine into cyclopamine. Fitoterapia. 2012;83:1238-41 pubmed publisher
    ..The mild reaction conditions, high overall yield as well as an easy purification indicate this process can potentially be used for the scale-up preparation of cyclopamine. ..
  48. Hao D, Gu X, Xiao P, Peng Y. Phytochemical and biological research of Fritillaria medicine resources. Chin J Nat Med. 2013;11:330-44 pubmed publisher
    The genus Fritillaria is a botanical source for various pharmaceutically active components, which have been commonly used in traditional Chinese medicine for thousands of years...
  49. Tan S, Liu C, Wang C, Wang D, Zhang Y, Lin N. [Valuation on analgesic, expectorant and antitussive effects of compatible use of Aconiti radix cocta and Fritillaria cirrhosa or Fritillaria thunbergii]. Zhongguo Zhong Yao Za Zhi. 2013;38:2706-13 pubmed
    To study the analgesic, expectorant and antitussive effects of the compatible use of Aconiti Radix Cocta and Fritillaria cirrhosa or F. thunbergii with different matching ratio or dose in mice...
  50. Ruan X, Yang L, Cui W, Zhang M, Li Z, Liu B, et al. Optimization of Supercritical Fluid Extraction of Total Alkaloids, Peimisine, Peimine and Peiminine from the Bulb of Fritillaria thunbergii Miq, and Evaluation of Antioxidant Activities of the Extracts. Materials (Basel). 2016;9: pubmed publisher
    ..extraction (SFE) was used to extract total alkaloids, peimisine, peimine and peiminine from the bulb of Fritillaria thunbergii Miq...
  51. Chen S, Jia M, Wang Y, Xue G, Xiao P. [Study on the plant community of Fritillaria cirrhosa]. Zhongguo Zhong Yao Za Zhi. 2003;28:398-402 pubmed
    To provide scientific basis for natural cultivation of Fritillaria cirrhosa. The cluster analysis to the Bray--Curtis distance coefficient of community plot was carried out to divide the community types of F. cirrhosa. The community of F...
  52. Yu R, Cheng Z, Gong X. [Determination and comparison of trace elements in four sorts of Bulbus Fritillariae by microwave digestion-atomic absorption spectrometry]. Guang Pu Xue Yu Guang Pu Fen Xi. 2007;27:2591-4 pubmed
    ..Zn, Fe, Mn, Cu, Na, Mg, K, Ca, As, Pb, Cd, Co, Cr, Sr, and Al in four sorts of Bulbus Fritillariae, namaly from Fritillaria thunbergii Miq. (Panan and Ningbo), Fritillaria thunbergii Miq. Var. chekiangensis Hsiao et K. C...
  53. Li H, Jiang Y, Li P. Characterizing distribution of steroidal alkaloids in Fritillaria spp. and related compound formulas by liquid chromatography-mass spectrometry combined with hierarchial cluster analysis. J Chromatogr A. 2009;1216:2142-9 pubmed publisher
    Bulbus Fritillariae (BF), referred to the bulbs of several Fritillaria species (Liliaceae), is a commonly used antitussive and expectorant herb in traditional Chinese medicine (TCM)...
  54. Liu H, Chen S, Yao H, Li X, Zhang Y. [Research progress on resources in Bulbus Fritillariae Cirrhosae]. Zhongguo Zhong Yao Za Zhi. 2008;33:1645-8 pubmed
    ..The present problems and the future research direction on bulbus fritillariae cirrhosae were also discussed. ..
  55. Cho I, Lee M, Kim J, Han N, Shin K, Sohn Y, et al. Fritillaria ussuriensis extract inhibits the production of inflammatory cytokine and MAPKs in mast cells. Biosci Biotechnol Biochem. 2011;75:1440-5 pubmed
    b>Fritillaria ussuriensis (FU, derived from the bulbs of various species of the genus Fritillaria, including Fritillaria thunbergii Miq.) is used in herbal medicine to treat conditions such as eczema, skin burns, and frostbite...
  56. Zarei O, Yaghoobi M. Cytotoxic effects of Fritillaria imperialis L. extracts on human liver cancer cells, breast cancer cells and fibroblast-like cells. Biomed Pharmacother. 2017;94:598-604 pubmed publisher
    In this study, we evaluated the cytotoxic effects of Fritillaria imperialis L. aqueous and ethanolic extracts on human liver cancer cells (LCL-PI 11), breast adenocarcinoma cells (MCF-7) and fibroblast-like cells (HSkMC)...
  57. Yeum H, Lee Y, Kim S, Roh S, Lee J, Seo Y. Fritillaria cirrhosa, Anemarrhena asphodeloides, Lee-Mo-Tang and cyclosporine a inhibit ovalbumin-induced eosinophil accumulation and Th2-mediated bronchial hyperresponsiveness in a murine model of asthma. Basic Clin Pharmacol Toxicol. 2007;100:205-13 pubmed
    ..b>Fritillaria cirrhosa, Anemarrhena asphodeloides and Lee-Mo-Tang are well-known herbs used in oriental medicine for the ..
  58. Zhou J, Li P, Li H, Jiang Y, Ren M, Liu Y. Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species. J Chromatogr A. 2008;1177:126-37 pubmed
    ..naturally occurring nitrogen-containing compounds in many edible or medicinal plants, such as potato, tomato, Fritillaria and American hellebore, which possess a variety of toxicological and pharmacological effects on humans...
  59. Zheng Z, Li D, Chen X. [Study on the compound Fritilaria thunbergii Miq particles to the subcellular accumulation ability and inducing apoptosis of K562/A02 cells]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010;30:167-9 pubmed
    To investigate the effects of the Compound Fritillaria thunbergii Miq Particles (CFMP) to the sub-cellular accumulation ability and inducing the apoptosis of K562/A02 cells, explore the mechanism of the CFMP reserve the multi-drug ..
  60. Wang H, Ma P, Peng R. [Quantitative determination of peimisin and total alkaloids in Fritillaria taipaiensis of different growing stage]. Zhong Yao Cai. 2011;34:1034-7 pubmed
    ..taipaiensis increased with growing stage, from five to six years, it decreased with growing stage. It is suitable to harvest F. taipaienssi of four years growing stage. ..
  61. Chen L, Zhang H, Guan Z, Zhu W, Yi W, Guan Y, et al. Sex dependent pharmacokinetics, tissue distribution and excretion of peimine and peiminine in rats assessed by liquid chromatography-tandem mass spectrometry. J Ethnopharmacol. 2013;145:77-84 pubmed publisher
    b>Fritillaria thunbergii Miq. has been traditionally used in China as antitussive and expectorant herbs, and newly used in the clinical treatment of leukemia in recent years...
  62. Wang L, Yao Z, Li P, Chen S, So P, Shi Z, et al. Global detection and semi-quantification of Fritillaria alkaloids in Fritillariae Ussuriensis Bulbus by a non-targeted multiple reaction monitoring approach. J Sep Sci. 2016;39:287-95 pubmed publisher
    ..Applying this strategy, 59 Fritillaria alkaloids in Fritillariae Ussuriensis Bulbus have been classified, and 51 of these Fritillaria alkaloids were ..
  63. Hua R, Sun S, Zhou Q, Noda I, Wang B. Discrimination of Fritillary according to geographical origin with Fourier transform infrared spectroscopy and two-dimensional correlation IR spectroscopy. J Pharm Biomed Anal. 2003;33:199-209 pubmed
    b>Fritillaria is a traditional Chinese herbal medicine for eliminating phlegm and relieving a cough with a long history in China and some other Asian countries...
  64. Helsper J, Bücking M, Muresan S, Blaas J, Wietsma W. Identification of the volatile component(s) causing the characteristic foxy odor in various cultivars of Fritillaria imperialis L. (Liliaceae). J Agric Food Chem. 2006;54:5087-91 pubmed
    To identify the component(s) causing the foxy odor, characteristic for some Fritillaria imperialis cultivars, the headspace of flower bulbs was analyzed using gas chromatography-olfactometry (GC-O) and GC-mass spectrometry (GC-MS)...
  65. Mohammadi Dehcheshmeh M, Khalighi A, Naderi R, Ebrahimie E, Sardari M. Indirect somatic embryogenesis from petal explant of endangered wild population of Fritillaria imperialis. Pak J Biol Sci. 2007;10:1875-9 pubmed
    b>Fritillaria imperialis is an endangered bulbous plant and therefore in vitro micropropagation of this plant will have a great importance for germplasm conservation and commercial production...
  66. Wang Y, Dai Y, He Z, Sun Y, Yan S, Xu S, et al. [The effects of in vitro culture conditions on regeneration of Fritillaria cirrhosa]. Zhong Yao Cai. 2010;33:854-6 pubmed
    The optimal in vitro culture conditions for the regeneration of Fritillaria cirrhosa were screened.
  67. Chen L, Liu L, Zhu W, Zhang H, Yan Z, Liu H. Comparative pharmacokinetic studies of peimine and peiminine in rat plasma by LC-MS-MS after oral administration of Fritillaria thunbergii Miq. and Fritillaria thunbergii Miq. - Glycyrrhiza uralensis Fisch. couple extract. Pharmazie. 2011;66:684-9 pubmed
    ..applied to pharmacokinetic study of peimine and peiminine in rat plasma after oral administration of Fritillaria thunbergii Miq. exact and Fritillaria thunbergii Miq. - Glycyrrhiza uralensis Fisch. couple extract...
  68. Akhtar M, Atta Ur Rahman -, Choudhary M, Sener B, Erdogan I, Tsuda Y. New class of steroidal alkaloids from Fritillaria imperialis. Phytochemistry. 2003;63:115-22 pubmed
    ..and a known base, korsevine (4). were isolated from the bulbs of Fritillaria imperialis...
  69. Zhang Y, Ruan H, Pi H, Wu J, Sun H, Fujita T. Structural elucidation of fritillahupehin from bulbs of Fritillaria hupehensis Hsiao et K.C. Hsia. J Asian Nat Prod Res. 2004;6:29-34 pubmed
    ..fatty acids, palmitic acid (2), lignoceric acid (3) and azelaric acid (4), have been isolated from the bulbs of Fritillaria hupehensis Hsiao et K.C. Hsia...
  70. Ye X, Yu H, Li P. [Analysis of Chinese drug beimu and its fake species with clustering analysis and FTIR spectra]. Zhong Yao Cai. 2005;28:89-91 pubmed
    ..To identify Chinese drug Beimu from its fake species...
  71. Shou Q, Tan Q, Wu Shen Z. Two 22S-solanidine-type steroidal alkaloids from Fritillaria anhuiensis. Fitoterapia. 2010;81:81-4 pubmed publisher
    Phytochemical investigation of the fresh bulbs of Fritillaria anhuiensis S. C. Chen et S. E...
  72. Zhang S, Wei J, Chen S, Dai Y, Li X. [Floral dynamic and pollination habit of Fritillaria cirrhosa]. Zhongguo Zhong Yao Za Zhi. 2010;35:27-9 pubmed
    To find the sexual reproduction characteristics and improve the seed propagation and new variety breeding of Fritillaria cirrhosa.
  73. Zhang J, Song C, Chen B, Yao S. [Simultaneous determination of five nucleotides in Bulbus Fritillariae by RP-HPLC]. Zhongguo Zhong Yao Za Zhi. 2010;35:67-70 pubmed
    ..thunberqii > F. cirrhosa approximately F. ussuriensis. The method is simple, convenient and accurate. It can be used for the determination of nucleosides and supplying evidence for exploiting and applying of Bulbus Fritillariae...
  74. Zhang Y, Lu B, Wang K, Zhang X, Wu W. [Karyotype and pollen morphology of main Fritillaria thunbergii cultivars]. Zhongguo Zhong Yao Za Zhi. 2013;38:3265-70 pubmed
    ..To study the differences in pollen morphology and karyotype among main Fritillari thunbergii cultivars...
  75. Li Y, Yili A, Li J, Muhamat A, Aisa H. New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk. Bioorg Med Chem Lett. 2016;26:1983-7 pubmed publisher
    ..5), imperialine (6), imperialine β-N-oxide (7), and dongbeinine (8), were isolated from the bulbs of Fritillaria pallidiflora...
  76. Li P, Zeng L, Li S, Lin G. The extraction of imperialine and imperialine-3 beta-glucoside from Fritillaria pallidiflora Schrenk and quantitative determination by HPLC-evaporative light scattering detection. Phytochem Anal. 2002;13:158-61 pubmed
    ..of the main bioactive components, namely, imperialine (1) and imperialine-3 beta-glucoside (2), of bulbs of Fritillaria pallidiflora Schrenk have been investigated...
  77. Tsuda Y, Atta Ur Rahman -, Akhtar M, Sener B, Parvez M, Sashida Y, et al. The structure of a new crystalline cevane alkaloid: its identity with persicanidine B and harepermine. Nat Prod Res. 2004;18:205-9 pubmed
    The structure of a new crystalline base (melting point (mp) 167-169 degrees C) obtained from Fritillaria imperialis was elucidated as (20R, 25R)-5alpha,17beta-cevanine-3beta,6beta-diol, X-ray diffraction analysis of the mono-hydrate...
  78. Chen Q, Zhu L, Xu Y, Fan J. [A new steroidal alkaloid from the bulbus of Fritillaria wabuensia]. Yao Xue Xue Bao. 2004;39:348-50 pubmed
    To investigate the chemical constituents of the bulbs of Fritillaria wabuensia.
  79. Atta Ur Rahman -, Akhtar M, Choudhary M, Tsuda Y, Yasin A, Sener B, et al. New diterpene isopimara-7,15-dien-19-oic acid and its prolyl endopeptidase inhibitory activity. Nat Prod Res. 2005;19:13-22 pubmed
    The ethanolic extract of the bulbs of Fritillaria imperialis was subjected to fractionation by solvent-solvent extraction. The nonpolar fraction showed inhibitory activity against prolyl endopeptidase (PEP) (EC.3.4.21...
  80. Yao Y, Xu G, Zhang J, Li C, Li D. [Determination of trace elements in traditional Chinese medicine from Changbai Mountain by ICP-MS]. Guang Pu Xue Yu Guang Pu Fen Xi. 2008;28:1165-7 pubmed
    The effects of different digestives for the fritillaria and atractylodes were compared...
  81. Chen L, Liu L, Liu H, Zhu W, Yi W, Zhao Y. [Simultaneous determination of peimine and peiminine in rat plasma by LC-MS/MS and its application in the pharmacokinetic study]. Yao Xue Xue Bao. 2010;45:891-4 pubmed
    ..simultaneous determination of peimine and peiminine in rat plasma after oral and intravenous administration of Fritillaria thunbergii Miq. extract, the pharmacokinetic parameters were calculated as well...
  82. Niitepõld K, Mattila A, Harrison P, Hanski I. Flight metabolic rate has contrasting effects on dispersal in the two sexes of the Glanville fritillary butterfly. Oecologia. 2011;165:847-54 pubmed publisher
    ..Thus, flight capacity has opposite associations with dispersal rate in the two sexes...
  83. Xu J, Guo P, Liu C, Sun Z, Gui L, Guo Y, et al. Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis. Biosci Biotechnol Biochem. 2011;75:1386-8 pubmed
    ..ent-3?-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis...
  84. Wei C, Yao H, Yang Y, Liu C. [Prokaryotic expression of LMoV CP gene and preparation of its antiserum]. Zhong Yao Cai. 2011;34:1182-6 pubmed
    ..To prepare antiserum against the CP of Lilg mottle virus (LMoV)...
  85. Kim E, Yoon Y, Woo K, Kim J, Min S, Lee H, et al. Verticine, ebeiedine and suchengbeisine isolated from the bulbs of Fritillaria thunbergii Miq. inhibited the gene expression and production of MUC5AC mucin from human airway epithelial cells. Phytomedicine. 2016;23:95-104 pubmed publisher
    The bulb of Fritillaria thunbergii has been utilised as mucoregulators and expectorants for controlling the airway inflammatory diseases in folk medicine...
  86. Liu Y, Feng Y, Lu X, Nie J, Li W, Wang L, et al. Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii. Eur J Med Chem. 2017;137:280-291 pubmed publisher
    ..A (1), walujewine B (4), walujewine C (5), walujewine D (6), walujewine E (10) were isolated from the bulbs of Fritillaria walujewii together with seven known isosteroidal alkaloids (2, 3, 7-9, 11, 12)...
  87. Evtushenko L, Dorofeeva L, Krausova V, Gavrish E, Yashina S, Takeuchi M. Okibacterium fritillariae gen. nov., sp. nov., a novel genus of the family Microbacteriaceae. Int J Syst Evol Microbiol. 2002;52:987-93 pubmed
    ..IFO 16404T) is proposed for aerobic, oxidase- and catalase-positive, coryneform bacteria isolated from seeds of Fritillaria ruthenica Wikstr. and Clematis recta L...
  88. Li S, Li P, Zheng L. [Determination of imperialine and imperialine-3 beta-D-glucoside in bulbs of Fritillaria pallidiflora by HPLC-ELSD]. Yao Xue Xue Bao. 2001;36:300-2 pubmed
    ..HPLC (high performance liquid chromatography)-ELSD (evaporative light scattering detector) method for the quantification of chromophore-lacking imperialine (I) and imperialine-3 beta-D-glucoside (II) in bulbs of Fritillaria pallidiflora.
  89. Wang S, Gao W, Yu J, Xiao P. [Identification of Fritillaria herbal drugs by X-ray diffraction of starch grains]. Zhongguo Zhong Yao Za Zhi. 2005;30:805-7 pubmed
    To provide a simple method to identify different of herbal drugs of Fritillaria.
  90. Wang S, Gao W, Yu J, Xiao P. [Progress of taxonomic study on Fritillaria (Liliaceae) medicinal plant]. Zhongguo Zhong Yao Za Zhi. 2007;32:1609-14 pubmed
    In this review, we described the taxonomic study of the Fritillaria medicinal plant in the recent years...
  91. Li K, Wu W, Zheng Y, Dai Y, Mou L, Liao K. [Effect of temperature on physiologic indexes, bulb yielding and total alkaloids contents of Fritillaria cirrhosa]. Zhongguo Zhong Yao Za Zhi. 2008;33:1948-51 pubmed
    To study the physiologic indexes, yield and the contents of alkaloids of Fritillaria cirrhosa D. Don under different temperature.
  92. Chen T, Zhang L, Zhou X, Shu G, Zhou Y. [Preliminary study of fertilizer effect on yield and quality of Fritillaria ussuriensis]. Zhongguo Zhong Yao Za Zhi. 2009;34:544-6 pubmed
    To preliminarily study the effect of fertilizer methods on the yield and quality of Fritillaria ussuriensis.