Summary: A plant genus of the family Asparagaceae. This should not be confused with Broom or Scotch Broom (CYTISUS) or Desert Broom (BACCHARIS) or Spanish Broom (SPARTIUM) or Brome (BROMUS).

Top Publications

  1. Maswadeh H, Semreen M, Naddaf A. Anti-inflammatory activity of Achillea and Ruscus topical gel on carrageenan-induced paw edema in rats. Acta Pol Pharm. 2006;63:277-80 pubmed
    The anti-inflammatory activity of Achillea and Ruscus extracts was studied in comparison with diclofenac sodium topical gel (diclosal Emulgel), using the carrageenan induced paw edema model in Albino rats...
  2. Allaert F. Combination of Ruscus aculeatus extract, hesperidin methyl chalcone and ascorbic acid: a comprehensive review of their pharmacological and clinical effects and of the pathophysiology of chronic venous disease. Int Angiol. 2016;35:111-6 pubmed
    This paper focuses on Ruscus aculeatus extract (Ruscus extract) and its combination with hesperidin methyl chalcone (HMC) and ascorbic acid (AA), which have been safely and effectively used in CVD treatment for more than 50 years in some ..
  3. Kakkos S, Allaert F. Efficacy of Ruscus extract, HMC and vitamin C, constituents of Cyclo 3 fort®, on improving individual venous symptoms and edema: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials. Int Angiol. 2017;36:93-106 pubmed publisher
    ..The aim of the present systematic review and meta-analysis was to study the effectiveness of VADs containing Ruscus across the spectrum of defined venous symptoms...
  4. Jawien A, Bouskela E, Allaert F, Nicolaides A. The place of Ruscus extract, hesperidin methyl chalcone, and vitamin C in the management of chronic venous disease. Int Angiol. 2017;36:31-41 pubmed publisher
    ..The symposium "The place of Ruscus extract, hesperidin methyl chalcone, and vitamin C in the management of CVD", held at the Annual Meeting of the ..
  5. Rauly Lestienne I, Heusler P, Cussac D, Lantoine Adam F, de Almeida Cyrino F, Bouskela E. Contribution of muscarinic receptors to in vitro and in vivo effects of Ruscus extract. Microvasc Res. 2017;114:1-11 pubmed publisher
    ..of this study were to evaluate, in vitro and in vivo, the contribution of muscarinic receptors to the effects of Ruscus extract...
  6. Masullo M, Pizza C, Piacente S. Ruscus Genus: A Rich Source of Bioactive Steroidal Saponins. Planta Med. 2016;82:1513-1524 pubmed
    The genus Ruscus (Asparagaceae family) is native to the Mediterranean, Southern and Western Europe and is represented by perennial, rhizomatous, and evergreen shrubs...
  7. Del Gaudio F, Festa C, Mozzicafreddo M, Vasaturo M, Casapullo A, De Marino S, et al. Biomolecular proteomics discloses ATP synthase as the main target of the natural glycoside deglucoruscin. Mol Biosyst. 2016;12:3132-8 pubmed publisher
    Extracts of Ruscus aculeatus are a rich source of bioactive steroidal glycosides, such as ruscogenins which are reported to act against chronic venous disorders...
  8. de Almeida Cyrino F, Balthazar D, Sicuro F, Bouskela E. Effects of venotonic drugs on the microcirculation: Comparison between Ruscus extract and micronized diosmine1. Clin Hemorheol Microcirc. 2018;68:371-382 pubmed publisher
    ..In this investigation we have tested the effects of two commonly used venotonic substances, Ruscus extract and micronized diosmine, on the microcirculation in vivo...
  9. Zhang H, Xu T, Gao L, Liu X, Liu J, Yu B. A Novel Fluoroimmunoassay for Detecting Ruscogenin with Monoclonal Antibodies Conjugated with CdSe/ZnS Quantum Dots. Molecules. 2017;22: pubmed publisher
    Ruscogenin (RUS) is a steroidal sapogenin found in Ruscus aculeatus and Ophiopogon japonicus with several pharmacological activities...

More Information


  1. Dehghan H, Sarrafi Y, Salehi P. Antioxidant and antidiabetic activities of 11 herbal plants from Hyrcania region, Iran. J Food Drug Anal. 2016;24:179-188 pubmed publisher
    ..caucasicum, Heracleum persicum, Pimpinella affinis, Parrotia persica, Primula heterochroma, Pyrus boissieriana, Ruscus hyrcanus, and Smilax excelsa were investigated...
  2. Kakkos S, Bouskela E, Jawien A, Nicolaides A. New data on chronic venous disease: a new place for Cyclo 3® Fort. Int Angiol. 2018;37:85-92 pubmed publisher
    ..of the European Venous Forum on June 30th, 2017 in Porto, Portugal, reported the recent developments on the Ruscus, hesperidin methyl chalcone (HMC), and vitamin C combination (Cyclo 3® Fort), including the results of a series ..
  3. De Combarieu E, Falzoni M, Fuzzati N, Gattesco F, Giori A, Lovati M, et al. Identification of Ruscus steroidal saponins by HPLC-MS analysis. Fitoterapia. 2002;73:583-96 pubmed
    ..HPLC-UV method has been developed for the fingerprint analysis of the steroidal saponins in the rhizomes of three Ruscus species (Ruscus aculeatus, Ruscus hypoglossum and Ruscus colchicus). Saponins were identified by HPLC-ESI-MS...
  4. Chudek J, Mikosiński J, Kobielski A, Hering A, Aleksiejew Kleszczyński T, Umiński J, et al. Patients' satisfaction with therapy methods of advanced chronic venous disease. Int Angiol. 2016;35:98-107 pubmed
    ..6% with VADs ‑ with highest rate of satisfied patients in the group taking Ruscus aculeatus and HMC and ascorbic acid (51.4%)...
  5. Sadarmin P, Timperley J. An unusual case of Butcher's Broom precipitating diabetic ketoacidosis. J Emerg Med. 2013;45:e63-5 pubmed publisher
    ..Herbal medicines are readily available and commonly perceived to be relatively harmless. Butcher's Broom is used in various medicinal preparations and contains substances having ?-adrenergic-stimulating properties...
  6. De Marino S, Festa C, Zollo F, Iorizzi M. Novel steroidal components from the underground parts of Ruscus aculeatus L. Molecules. 2012;17:14002-14 pubmed publisher
    ..saponins 1–2 and three new sulphated glycosides 3a,b and 4 were isolated from the underground parts of Ruscus aculeatus L., along with four known furostanol and one spirostanol saponins 5–9 and three free sterols...
  7. Barbic M, Schmidt T, Jürgenliemk G. Novel phenyl-1-benzoxepinols from butcher's broom (Rusci rhizoma). Chem Biodivers. 2012;9:1077-83 pubmed publisher
    ..The structures were elucidated by spectroscopic methods such as 1D- and 2D-NMR (COSY, HSQC, HMBC, ROESY), and HR-EI-MS experiments. The absolute configuration of the ruscozepines was determined by electronic circular dichroism...
  8. Allaert F, Hugue C, Cazaubon M, Renaudin J, Clavel T, Escourrou P. Correlation between improvement in functional signs and plethysmographic parameters during venoactive treatment (Cyclo 3 Fort). Int Angiol. 2011;30:272-7 pubmed functional signs of venous insufficiency and venous refilling time measured by mercury strain-gauge plethysmography under the effects of the combination of Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid (Cyclo 3 Fort).
  9. Perrone A, Muzashvili T, Napolitano A, Skhirtladze A, Kemertelidze E, Pizza C, et al. Steroidal glycosides from the leaves of Ruscus colchicus: isolation and structural elucidation based on a preliminary liquid chromatography-electrospray ionization tandem mass spectrometry profiling. Phytochemistry. 2009;70:2078-88 pubmed publisher
    ..tool to rapidly identify and guide the isolation of target saponins from the ethanol extract of the leaves of Ruscus colchicus Y. Yeo...
  10. Longo L, Vasapollo G. Determination of anthocyanins in Ruscus aculeatus L. berries. J Agric Food Chem. 2005;53:475-9 pubmed
    Red berries of Ruscus aculeatus L., a wild shrub typical of Mediterranean Europe and Africa, were investigated for the first time in order to determine the profile of anthocyanins...
  11. Maleki Dizaji N, Fathiazad F, Garjani A. Antinociceptive properties of extracts and two flavonoids isolated from leaves of Danae racemosa. Arch Pharm Res. 2007;30:1536-42 pubmed
    ..Finally, the active principle(s) responsible for the antinociceptive action of D. racemosa is likely to be partially related to the presence of quercetin and kaempferol...
  12. Ramírez Hernández M, García Sellés J, Mérida Fernández C, Martinez Escribano J. Allergic contact dermatitis to ruscogenins. Contact Dermatitis. 2006;54:60 pubmed
  13. Palazon J, Moyano E, Bonfill M, Osuna L, Cusido R, Piñol M. Effect of organogenesis on steroidal saponin biosynthesis in calli cultures of Ruscus aculeatus. Fitoterapia. 2006;77:216-20 pubmed
    Calli cultures derived from Ruscus aculeatus rhizomes were investigated for their potential to biosynthesize saponins...
  14. Napolitano A, Muzashvili T, Perrone A, Pizza C, Kemertelidze E, Piacente S. Steroidal glycosides from Ruscus ponticus. Phytochemistry. 2011;72:651-61 pubmed publisher
    A comparative metabolite profiling of the underground parts and leaves of Ruscus ponticus was obtained by an HPLC-ESIMS(n) method, based on high-performance liquid chromatography coupled to electrospray positive ionization multistage ion ..
  15. Mesbah H, Fata A, Moursi K, Mourad A, Abdel Razak S. The population dynamics of Fiorinia fioriniae (Targioni) (Homoptera: Diaspididae) and factors affecting its seasonal abundance in Egypt. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2001;66:537-44 pubmed
    ..was observed attacking Callistemon lanceolatus at the Experimental Farm of the Agricultural Research Station and Ruscus hypoglossum at Antoniades park in Alexandria Governorate; Egypt...
  16. Consoli A. [Chronic venous insufficiency: an open trial of FLEBS Crema]. Minerva Cardioangiol. 2003;51:411-6 pubmed
    ..This compound acts as vasoconstrictor thanks to the vegetable extract of Ruscus aculeatus, but it is also able to reduce the edema, thanks to the vegetable extract of Melilotus officinalis.
  17. Seaver B, Smith J. Inhibition of COX isoforms by nutraceuticals. J Herb Pharmacother. 2004;4:11-8 pubmed
    ..Positive results were seen for ipriflavone, resveratrol, MSV-60, amentoflavone, ruscus extract and notoginseng. Glucosamine, nexrutine, and berberine did not inhibit either isoform.
  18. Bylka W, Kornobis J. [Butcher's Broom, in the treatment of venous insufficiency]. Pol Merkur Lekarski. 2005;19:234-6 pubmed
    ..This review is concerning Rusci aculeati rhizoma, which recently taken in Poland on the symptoms of chronic venous insufficiency and hemorrhoids...
  19. Mangas S, Bonfill M, Osuna L, Moyano E, Tortoriello J, Cusido R, et al. The effect of methyl jasmonate on triterpene and sterol metabolisms of Centella asiatica, Ruscus aculeatus and Galphimia glauca cultured plants. Phytochemistry. 2006;67:2041-9 pubmed
    ..we have studied Centella asiatica and Galphimia glauca (both synthesizing triterpenoid secondary compounds) and Ruscus aculeatus (which synthesizes steroidal secondary compounds) for their growth rate and content of free sterols and ..
  20. Stoianova V. [Cyclo 3 fort--alternative in chronic venous insufficiency]. Akush Ginekol (Sofiia). 2006;45 Suppl 3:78-80 pubmed
  21. Calapai G, Minciullo P, Miroddi M, Chinou I, Gangemi S, Schmidt R. Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - Part 3: Mentha × piperita - Solanum dulcamara. Contact Dermatitis. 2016;74:131-44 pubmed publisher
    ..Part 3: Mentha × piperita L.-Solanum dulcamara L. ..
  22. Cesarone M, Belcaro G, Grossi M, Pellegrini L, Ledda A, Vinciguerra G, et al. LINFAVENIX: improvement of signs and symptoms of chronic venous insufficiency and microangiopathy. Minerva Cardioangiol. 2008;56:55-61 pubmed
    ..In conclusion venous microangiopathy and edema were improved by the treatment with Linfavenix (better in comparison with compression) in a few days...
  23. Guex J, Enriquez Vega D, Avril L, Boussetta S, Taieb C. Assessment of quality of life in Mexican patients suffering from chronic venous disorder - impact of oral Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid treatment - 'QUALITY Study'. Phlebology. 2009;24:157-65 pubmed publisher
    The present study assessed the effect of Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid (HMC-AA) on the quality of life (QoL) of patients suffering from chronic venous disorders (CVDs).
  24. Vlase L, Kiss B, Balica G, Tamas M, Crisan G, Leucuta S. High-throughput LC/MS/MS analysis of ruscogenin and neoruscogenin in Ruscus aculeatus L. J AOAC Int. 2009;92:1055-9 pubmed
    ..LC/MS/MS method was developed for the quantification of ruscogenin and neoruscogenin in hydrolyzed extracts from Ruscus aculeatus L. (Liliaceae). The two sapogenins were separated on a Zorbax SB-C18 column under isocratic conditions...
  25. Aguilar Peralta G, Arévalo Gardoqui J, Llamas Macías F, Navarro Ceja V, Mendoza Cisneros S, Martínez Macías C. Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients. Int Angiol. 2007;26:378-84 pubmed
    Clinical and capillaroscopic evaluation of an association of Ruscus aculeatus, hesperidin methylchalcone (HMC) and ascorbic acid in chronic venous insufficiency
  26. Guex J, Avril L, Enrici E, Enriquez E, Lis C, Taieb C. Quality of life improvement in Latin American patients suffering from chronic venous disorder using a combination of Ruscus aculeatus and hesperidin methyl-chalcone and ascorbic acid (quality study). Int Angiol. 2010;29:525-32 pubmed
    The present study assessed the effect of Ruscus aculeatus, hesperidin methyl-chalcone and ascorbic acid (HMC-AA), in the treatment of chronic venous disorders (CVD) in Latin American patients.