polygonatum

Summary

Summary: A plant genus of the family Asparagaceae. Members contain benzoquinones, steroidal saponin, and ribosome-inactivating proteins.

Top Publications

  1. Ahn M, Kim C, Yoon K, Ryu M, Cheong J, Chin Y, et al. Steroidal saponins from the rhizomes of Polygonatum sibiricum. J Nat Prod. 2006;69:360-4 pubmed
    Four new steroidal saponins, named neosibiricosides A-D (1-4), were isolated from the rhizomes of Polygonatum sibiricum, along with two known spirostanol glycosides...
  2. Shu X, Lv J, Tao J, Li G, Li H, Ma N. Antihyperglycemic effects of total flavonoids from Polygonatum odoratum in STZ and alloxan-induced diabetic rats. J Ethnopharmacol. 2009;124:539-43 pubmed publisher
    Total flavonids of Polygonatum(P) odoratum (TFP) were tested for anti-diabetic activity in streptozotocin (STZ)-induced diabetic mice and alloxan-induced diabetic rats.
  3. Lu M, Hsieh M, Wu C, Cheng H, Hsieh C, Lin Y, et al. Ameliorating effect of emodin, a constitute of Polygonatum multiflorum, on cycloheximide-induced impairment of memory consolidation in rats. J Ethnopharmacol. 2007;112:552-6 pubmed
  4. Liu B, Cheng Y, Zhang B, Bian H, Bao J. Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway. Cancer Lett. 2009;275:54-60 pubmed publisher
    b>Polygonatum cyrtonema lectin (PCL), a mannose-binding lectin, has been reported to induce cytotoxicity and apoptosis. Herein, we demonstrated that PCL-induced apoptosis and autophagy in A375 cells...
  5. Liu B, Cheng Y, Bian H, Bao J. Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells. Autophagy. 2009;5:253-5 pubmed
    b>Polygonatum cyrtonema lectin (PCL), a mannose/sialic acid-binding lectin, has been reported to display remarkable inhibitory and cytotoxic activity toward cancer cells...
  6. Ahn M, Kim J. Identification and quantification of steroidal saponins in Polygonatum species by HPLC/ESI/MS. Arch Pharm Res. 2005;28:592-7 pubmed
    ..method has been developed to identify and quantify the spirostanol glycosides in the rhizomes of five Polygonatum species...
  7. Liu F, Liu Y, Meng Y, Yang M, He K. Structure of polysaccharide from Polygonatum cyrtonema Hua and the antiherpetic activity of its hydrolyzed fragments. Antiviral Res. 2004;63:183-9 pubmed
    A neutral polysaccharide named PD was isolated from the traditional Chinese medicinal herb, Polygonatum cyrtonema Hua. Five fragments were isolated by Bio-Gel P4 chromatography from hydrolysates of PD...
  8. Khan H, Saeed M, Gilani A, Khan M, Dar A, Khan I. The antinociceptive activity of Polygonatum verticillatum rhizomes in pain models. J Ethnopharmacol. 2010;127:521-7 pubmed publisher
    The current study was designed to establish the pharmacological rationale for the traditional use of the rhizomes of Polygonatum verticillatum in the treatment of painful conditions and as a plant diuretic.
  9. Wang D, Zeng L, Li D, Pu W. Antioxidant activities of different extracts and homoisoflavanones isolated from the Polygonatum odoratum. Nat Prod Res. 2013;27:1111-4 pubmed publisher
    The antioxidant activities of five extracts from Polygonatum odoratum rhizomes were measured by three antioxidant assays in vitro...

More Information

Publications99

  1. Zhang H, Yang F, Qi J, Song X, Hu Z, Zhu D, et al. Homoisoflavonoids from the fibrous roots of Polygonatum odoratum with glucose uptake-stimulatory activity in 3T3-L1 adipocytes. J Nat Prod. 2010;73:548-52 pubmed publisher
    The EtOAc-soluble fraction of a 90% MeOH extract of the fibrous roots of Polygonatum odoratum was found to potentiate insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes...
  2. Zeng G, Zhang Z, Lu L, Xiao D, Xiong C, Zhao Y, et al. Protective effects of Polygonatum sibiricum polysaccharide on ovariectomy-induced bone loss in rats. J Ethnopharmacol. 2011;136:224-9 pubmed publisher
    To assess the ability of traditional Chinese medicine Polygonatum sibiricum polysaccharide to prevent bone loss in the ovariectomized rat.
  3. Wang Y, Mu T, Chen J, Luo S. [Studies on chemical constituents from the root of Polygonatum kingianum]. Zhongguo Zhong Yao Za Zhi. 2003;28:524-7 pubmed
    To investigate the anti-HIV constituents from the root of Polygonatum kingianum.
  4. Deng Y, He K, Ye X, Chen X, Huang J, Li X, et al. Saponin rich fractions from Polygonatum odoratum (Mill.) Druce with more potential hypoglycemic effects. J Ethnopharmacol. 2012;141:228-33 pubmed publisher
    The root of Polygonatum odoratum (YuZhu), also a medicinal food has long been used for the treatment of diabetes. The objective of the study was to characterize the anti-diabetic active fractions or compounds in this herb.
  5. Park S, Hong S, Ahn I, Kim Y, Lee J. Huang-Lian-Jie-Du-Tang supplemented with Schisandra chinensis Baill. and Polygonatum odoratum Druce improved glucose tolerance by potentiating insulinotropic actions in islets in 90% pancreatectomized diabetic rats. Biosci Biotechnol Biochem. 2009;73:2384-92 pubmed
    ..The rise in hyperplasia was associated with elevated IRS2 and PDX-1 expression in the islets. In conclusion, HLJDT-M worked as an anti-diabetic prescription by enhancing insulinotropic actions in diabetic rats...
  6. Liu B, Zhang B, Min M, Bian H, Chen L, Liu Q, et al. Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L929 cells. Biochim Biophys Acta. 2009;1790:840-4 pubmed publisher
  7. Wang S, Yu Q, Bao J, Liu B. Polygonatum cyrtonema lectin, a potential antineoplastic drug targeting programmed cell death pathways. Biochem Biophys Res Commun. 2011;406:497-500 pubmed publisher
    b>Polygonatum cyrtonema lectin (PCL), a mannose/sialic acid-binding plant lectin, has recently drawn a rising attention for cancer biologists because PCL bears remarkable anti-tumor activities and thus inducing programmed cell death (PCD) ..
  8. Zhang X, Gereltu B, Zhaorigetu -, Narisu -. [Determination of relative molecular mass and composition for Polygonatum sibiricum polysaccharide by high performance liquid chromatography]. Se Pu. 2005;23:394-6 pubmed
    b>Polygonatum sibiricum Redoute (PSR) is a traditional Chinese medicine and Mongolia herbal medicine growing in Inner Mongolia...
  9. Guo H, Zhao H, Kanno Y, Li W, Mu Y, Kuang X, et al. A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate-activated protein kinase. Bioorg Med Chem Lett. 2013;23:3137-9 pubmed publisher
    ..From the rhizomes of Polygonatum odoratum (Mill...
  10. Yang Y, Xu H, Zhang Z, Liu J, Li W, Ming H, et al. Characterization, molecular cloning, and in silico analysis of a novel mannose-binding lectin from Polygonatum odoratum (Mill.) with anti-HSV-II and apoptosis-inducing activities. Phytomedicine. 2011;18:748-55 pubmed publisher
    b>Polygonatum odoratum lectin (POL), a novel mannose-binding lectin with anti-viral and apoptosis-inducing activities, was isolated from rhizomes of Polygonatum odoratum (Mill.) Druce. POL was a homo-tetramer with molecular weight of 11953...
  11. Choi S, Park S. A steroidal glycoside from Polygonatum odoratum (Mill.) Druce. improves insulin resistance but does not alter insulin secretion in 90% pancreatectomized rats. Biosci Biotechnol Biochem. 2002;66:2036-43 pubmed
    ..study was to investigate the effects of three steroidal glycosides (SG-100, SG-280, and SG-460) obtained from Polygonatum odoratum (Mill.) Druce...
  12. Kramp K, Huck S, Niketic M, Tomović G, Schmitt T. Multiple glacial refugia and complex postglacial range shifts of the obligatory woodland plant Polygonatum verticillatum (Convallariaceae). Plant Biol (Stuttg). 2009;11:392-404 pubmed publisher
    ..Therefore, we analysed the AFLPs of 198 individuals of Polygonatum verticillatum over a major part of its European distribution...
  13. Liu B, Wu J, Li J, Liu J, Li W, Li C, et al. Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways. Biochimie. 2010;92:1934-8 pubmed publisher
    b>Polygonatum cyrtonema lectin (PCL), a mannose/sialic acid-binding lectin, has been reported to display remarkable anti-proliferative and apoptosis-inducing activities toward a variety of cancer cells; however, the precise molecular ..
  14. Khan H, Saeed M, Gilani A, Khan M, Khan I, Ashraf N. Antinociceptive activity of aerial parts of Polygonatum verticillatum: attenuation of both peripheral and central pain mediators. Phytother Res. 2011;25:1024-30 pubmed publisher
    b>Polygonatum verticillatum All. is used traditionally as an analgesic and plant diuretic. The methanol extract of aerial parts of Polygonatum verticillatum (PA) was assessed in various experimental paradigms...
  15. Jiang Q, Lv Y, Dai W, Miao X, Zhong D. Extraction and bioactivity of polygonatum polysaccharides. Int J Biol Macromol. 2013;54:131-5 pubmed publisher
    The present study is to explore the optimal extraction parameters and liver protective effect of the polygonatum polysaccharides in vivo...
  16. Jin J, Zhang Y, Li H, Yang C. Cytotoxic steroidal saponins from Polygonatum zanlanscianense. J Nat Prod. 2004;67:1992-5 pubmed
    Four new steroidal saponins, polygonatosides A-D (1-4), were isolated from the rhizomes of Polygonatum zanlanscianense, together with six known spirostanols (5-10) and a known megastigmane glycoside (11)...
  17. Long T, Liu Z, Shang J, Zhou X, Yu S, Tian H, et al. Polygonatum sibiricum polysaccharides play anti-cancer effect through TLR4-MAPK/NF-?B signaling pathways. Int J Biol Macromol. 2018;111:813-821 pubmed publisher
    To investigate the anti-cancer effect of Polygonatum sibiricum polysaccharides (PSP) and the underlying mechanism...
  18. Li L, Thakur K, Liao B, Zhang J, Wei Z. Antioxidant and antimicrobial potential of polysaccharides sequentially extracted from Polygonatum cyrtonema Hua. Int J Biol Macromol. 2018;114:317-323 pubmed publisher
    We examined the antioxidant and antimicrobial attributes of Polygonatum cyrtonema Hua polysaccharides (HBSS, CHSS, DASS, CASS). The UV spectra and FT-IR results showed the purity and acidic nature of polysaccharides with ?-configurations...
  19. Liu H, Sun W, Gu L, Tu Y, Yu B, Hu H. Huaiqihuang Granules () reduce proteinuria by enhancing nephrin expression and regulating necrosis factor κB signaling pathway in adriamycin-induced nephropathy. Chin J Integr Med. 2017;23:279-287 pubmed publisher
    ..Granules (, HQH), a mixture of Chinese herbs including Trametes robiniophila Murr, Fructus Lycii and Polygonatum sibiricum, on adriamycininduced nephropathy (ADRN) in rats and its underlying mechanisms...
  20. Jiao J, Jia X, Liu P, Zhang Q, Liu F, Ma C, et al. Species identification of polygonati rhizoma in China by both morphological and molecular marker methods. C R Biol. 2018;341:102-110 pubmed publisher
    ..Of the five species identified: Polygonatum kingianum, P. cirrhifolium, P. alternicirrhosum, and P. sibiricum belonged to one cluster, and P...
  21. Yan H, Lu J, Wang Y, Gu W, Yang X, Yu J. Intake of total saponins and polysaccharides from Polygonatum kingianum affects the gut microbiota in diabetic rats. Phytomedicine. 2017;26:45-54 pubmed publisher
    The gut microbiota has been reported to play a critical role in metabolic diseases, including in diabetes. Polygonatum kingianum has been used in the treatment of diabetes and related diseases in China for centuries...
  22. Wang H, Shi S, Wang S. Can highly cited herbs in ancient Traditional Chinese medicine formulas and modern publications predict therapeutic targets for diabetes mellitus?. J Ethnopharmacol. 2018;213:101-110 pubmed publisher
    ..rhizoma, dried; Morus alba L., folium, dried, Morus alba L., fructus, dried; and Polygonatum odoratum (Mill...
  23. Lee J, Kim E, Kim M, Hong J, Yang W. Polygonatum stenophyllum improves menopausal obesity via regulation of lipolysis-related enzymes. J Nat Med. 2016;70:789-96 pubmed publisher
    ..b>Polygonatum stenophyllum (PS) rhizome, which is a traditional herbal remedy, has been used to treat various diseases ..
  24. Khan H, Saeed M, Muhammad N, Ghaffar R, Khan S, Hassan S. Antimicrobial activities of rhizomes of Polygonatum verticillatum: attributed to its total flavonoidal and phenolic contents. Pak J Pharm Sci. 2012;25:463-7 pubmed
    The current study was undertaken to evaluate the rhizomes of Polygonatum verticillatum against various pathogenic bacteria and fungi...
  25. Wang Y, Wang G, Wang L, Xu X, Xia J, Huang X, et al. [Isolation and identification of an endophytic fungus of Polygonatum cyrtonema and its antifungal metabolites]. Wei Sheng Wu Xue Bao. 2010;50:1036-43 pubmed
    ..In this study, an endophytic fungus zjqy610 with antifungal activity was isolated from Polygonatum cyrtonema in Zhejiang Qingyuan Baishanzu Mountain nature reserve...
  26. Khan H, Saeed M, Gilani A, Muhammad N, Haq I, Ashraf N, et al. Antipyretic and anticonvulsant activity of Polygonatum verticillatum: comparison of rhizomes and aerial parts. Phytother Res. 2013;27:468-71 pubmed publisher
    The current study was undertaken to explore the antipyretic and anticonvulsant profile of the Polygonatum verticillatum in established pharmacological paradigms...
  27. Wang D, Li D, Zhu W, Zhang J, Peng P. Steroidal saponins from the rhizomes of Polygonatum odoratum. Nat Prod Res. 2009;23:940-7 pubmed publisher
    Three steroidal saponins were isolated and characterised from the rhizomes of Polygonatum odoratum...
  28. Li L, Liao B, Thakur K, Zhang J, Wei Z. The rheological behavior of polysaccharides sequential extracted from Polygonatum cyrtonema Hua. Int J Biol Macromol. 2018;109:761-771 pubmed publisher
    ..investigated the rheological properties of polysaccharides (HBSS, CHSS, DASS, CASS) sequentially extracted from Polygonatum cyrtonema Hua...
  29. Wang J, Yue Y, Tang F, Tao W. [Comparative analysis of volatile fractions in Polygonati rhizoma and its processed products by GC-MS]. Zhongguo Zhong Yao Za Zhi. 2011;36:2187-91 pubmed
    ..Fifty-one compounds were checked out with SD-GC-MS, while 11 compounds with P&T-TD-GC-MS. This study is useful to illustrate the mechanism of decreasing toxicity and stimulating components after being processed. ..
  30. Luan W, Qian Y, Ni X, Chanda T, Xia Y, Wang J, et al. Polygonatum odoratum lectin promotes BECN1 expression and induces autophagy in malignant melanoma by regulation of miR1290. Onco Targets Ther. 2017;10:4569-4577 pubmed publisher
    ..i>Polygonatum odoratum lectin (POL) displays apoptosis- and autophagy-inducing effects in many human tumors...
  31. Liu N, Dong Z, Zhu X, Xu H, Zhao Z. Characterization and protective effect of Polygonatum sibiricum polysaccharide against cyclophosphamide-induced immunosuppression in Balb/c mice. Int J Biol Macromol. 2018;107:796-802 pubmed publisher
    In this study, the polysaccharide from Polygonatum sibiricum (PSP) was evaluated for the immunomodulatory activity by the cyclophosphamide (Cy)-induced immunosuppressed-model in vivo...
  32. Stefanowicz Hajduk J, Filipowicz N, Kosinski I, Ochocka J. Capillary electrophoresis with dual laser detection in separation of amplified fragment length polymorphism fragments. J Sep Sci. 2009;32:3539-43 pubmed publisher
    ..CE equipped with both argon ion and diode lasers is a good alternative for sequencers and might be applied in analyses of PCR products generated by various fingerprinting methods. ..
  33. Cheng M, Wang D. [The vicissitude of Huangjing (rhizome of king solomonseal) germplasm]. Zhonghua Yi Shi Za Zhi. 2009;39:17-20 pubmed
    Huangjing (rhizome of king solomonseal), originally recorded in Ming yi bie lu involved several kinds of Polygonatum plant. The Huangjing of Northern and Southern dynasties was derived from rhizome nodular groups of Polygonatum plant...
  34. Wang J, Yang Y, Sun H, Wen J, Deng T, Nie Z, et al. The Biogeographic South-North Divide of Polygonatum (Asparagaceae Tribe Polygonateae) within Eastern Asia and Its Recent Dispersals in the Northern Hemisphere. PLoS ONE. 2016;11:e0166134 pubmed publisher
    ..b>Polygonatum is an important medicinal genus widely distributed in the Northern Hemisphere with its highest species richness ..
  35. Keller T, Michel S, Frohlich J, Fink D, Caduff R, Marincek B, et al. USPIO-enhanced MRI for preoperative staging of gynecological pelvic tumors: preliminary results. Eur Radiol. 2004;14:937-44 pubmed
    ..However, the low sensitivity in the present study is a limitation for the clinical application of this technique. ..
  36. Khan H, Saeed M, Gilani A, Mehmood M, Rehman N, Muhammad N, et al. Bronchodilator activity of aerial parts of Polygonatum verticillatum augmented by anti-inflammatory activity: attenuation of Ca²? channels and lipoxygenase. Phytother Res. 2013;27:1288-92 pubmed publisher
    b>Polygonatum verticillatum is commonly used for the treatment of asthma and inflammation. The current study was aimed to scrutinize the pharmacological profile of methanolic extract of the aerial parts (PA)...
  37. Zhang H, Hu W, Ma G, Zhu N, Sun X, Wu H, et al. A new steroidal saponin from Polygonatum sibiricum. J Asian Nat Prod Res. 2017;:1-7 pubmed publisher
    ..saponin, kingianoside Z (1), along with four known compounds (2-5), was isolated from the ethanolic extract of Polygonatum sibiricum Delar. ex Redoute...
  38. Yang X, Chen S, Chen S, Yang D, Liu T. [Studies on TLC fingerprint of flavonoids in rhizome of Polygonatum odoratum]. Zhongguo Zhong Yao Za Zhi. 2005;30:104-6 pubmed
    To study the thin layer chromatographic (TLC) fingerprint of flavonoid constituents from Polygonatum odoratum, to set up the identification protocol of the herbal and provide scientific information for its quality control...
  39. Haupt H. [Poisonous and less poisonous plants]. Kinderkrankenschwester. 2002;21:164 pubmed
  40. Chen Y, Lu K, Li J, Liang D, Luo H, Wang X, et al. Structure and function analysis of Polygonatum cyrtonema lectin by site-directed mutagenesis. Acta Biochim Biophys Sin (Shanghai). 2017;:1-13 pubmed publisher
    The crystal structure of mature Polygonatum cyrtonema lectin (PCL) showed three similar carbohydrate-binding sites (CBS I, CBS II, and CBS III). The Gln58 and Asp60 residues of CBS II are substituted with His58 and Asn60...
  41. Yang Y, Xu M, Feng Y, He H. [Determination of 5-hydroxymethyl furfuraldehyde in different processed products of polygonatum]. Zhong Yao Cai. 2008;31:17-9 pubmed
    By finding the changing regularity of 5-Hydroxymethyl furfuraldehyde (5-HMF) content in Polygonatum for different time, this provides basis for the technology of processing Polygonatum and quality standards of its prepared pieces...
  42. Sharma V, Wani M, Singh V, Kaur K, Gupta R. Development and characterization of novel microsatellite markers in Trillium govanianum: a threatened plant species from North-Western Himalaya. 3 Biotech. 2017;7:190 pubmed publisher
    ..385. The cross-transferability in a related species, namely, Polygonatum verticillatum, showed amplification of ten markers...
  43. Sun L, Li X, Wang S. Two new alkaloids from the rhizome of Polygonatum sibiricum. J Asian Nat Prod Res. 2005;7:127-30 pubmed
    Two new alkaloids named polygonatine A (1) and polygonatine B (2) have been isolated from the rhizome of Polygonatum sibiricum Redoute (Liliaceae)...
  44. Bu J, Li D, Wang D. [Correlations between wild Polygonatum odoratum quality and main ecological factors]. Ying Yong Sheng Tai Xue Bao. 2012;23:1447-54 pubmed
    ..polysaccharides and water- and alcohol-soluble substances) contents and antioxidant activity of wild Polygonatum odoratum in different places and the ecological factors...
  45. Liu T, Wu L, Wang D, Wang H, Chen J, Yang C, et al. Role of reactive oxygen species-mediated MAPK and NF-?B activation in polygonatum cyrtonema lectin-induced apoptosis and autophagy in human lung adenocarcinoma A549 cells. J Biochem. 2016;160:315-324 pubmed
    b>Polygonatum cyrtonema lectin (PCL), a mannose/sialic acid-binding lectin isolated from the rhizomes of Polygonatum cyrtonema Hua, has been reported to possess remarkable anti-tumour effects via inducing apoptosis and autophagy...
  46. Lu J, Wang Y, Yan H, Lin P, Gu W, Yu J. Antidiabetic effect of total saponins from Polygonatum kingianum in streptozotocin-induced daibetic rats. J Ethnopharmacol. 2016;179:291-300 pubmed publisher
    b>Polygonatum kingianum has been used in the prevention and treatment of diabetes, hyperlipidemia and related metabolic syndrome in Asian counties for centuries...
  47. Li S, Guo X, Shu S, Huang R, Zhang X, Yang Z. [Cultivated technique of high yield for Polygonatum officinale]. Zhong Yao Cai. 1997;20:487-90 pubmed
    By studying cultivated materials, hided crops, cultivated way, applied fertilizer about the cultivation of Polygonatum officinale, put forward following the methods of cultivation of P. officinale...
  48. Zhang Z, Peng H, Li C, Liu J, Zhou T, Yan Y, et al. Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspase-dependent pathway as compared to Ophiopogon japonicus lectin. Phytomedicine. 2010;18:25-31 pubmed publisher
    ..In this study, we showed that Polygonatum cyrtonema lectin (PCL) and Ophiopogon japonicus lectin (OJL), the two mannose-binding GNA-related lectins, ..
  49. Jeon S, Lee M, Park Y, Park H, Choi M. Polygonatum rhizoma affects antioxidant defense systems without changing mRNA expression in diet-induced hypercholesterolemic rabbits. J Med Food. 2004;7:358-65 pubmed
    This study was conducted to determine the antioxidant effects of a Polygonatum extract compared with the major antioxidant, vitamin E, in rabbits fed a high-cholesterol diet. Rabbits were given a high-cholesterol (0...
  50. Liu T, Zheng X, Yang X, Lin L, Li Z. [Quantity study of cultivated and wild Rhizoma Polygonati Odorati]. Zhong Yao Cai. 2005;28:14-6 pubmed
    ..Contents of odoratan of Rhizoma Polygonati Odorati: wild Rhizoma Polygonati Odorati 9.67%, cultivated Rhizoma Polygonati Odorait 8.05%, wild > cultivated. ..
  51. Khan H, Saeed M, Gilani A, Muhammad N, Ur Rehman N, Mehmood M, et al. Antispasmodic and antidiarrheal activities of rhizomes of Polygonatum verticillatum maneuvered predominately through activation of K? channels: Components identification through TLC. Toxicol Ind Health. 2016;32:677-85 pubmed publisher
    b>Polygonatum verticillatum has traditionally been used for various purposes. The present study was aimed to validate the antispasmodic and antidiarrheal properties of crude methanolic extract of rhizomes of P. verticillatum (PR)...
  52. Zhao P, Zhao C, Li X, Gao Q, Huang L, Xiao P, et al. The genus Polygonatum: A review of ethnopharmacology, phytochemistry and pharmacology. J Ethnopharmacol. 2018;214:274-291 pubmed publisher
    The genus Polygonatum (Asparagaceae) comprises 71 species distributed throughout the temperate Northern Hemisphere...
  53. Cheng M, Wang D. [Anatomical structure and histochemical localization about rhizomes of five species of Polygonatum]. Zhongguo Zhong Yao Za Zhi. 2013;38:2068-72 pubmed
    The microscopic structure and histochemical localization of the Polygonatum sibiricum, P. cytonema, P. filipes, P. zanlanscianense and P. odoratum was studied.
  54. Wu B, Isobe K, Ishii R. Arbuscular mycorrhizal colonization of the dominant plant species in primary successional volcanic deserts on the Southeast slope of Mount Fuji. Mycorrhiza. 2004;14:391-5 pubmed
    ..Cirsium purpuratum and Campanula punctata ssp. hondoensis formed single structural types of Arum- and Paris-type, respectively, whereas P. cuspidatum and Clematis stans formed both Arum- and Paris-type morphologies...
  55. Wei X, Zhang J, Li J, Chen S. Astragalus mongholicus and Polygonum multiflorum's protective function against cyclophosphamide inhibitory effect on thymus. Am J Chin Med. 2004;32:669-80 pubmed
    ..Their protective effects partly attribute to reduced apoptosis. Astragalus mongholicus-polygonum multiflorum in combination has better effects than either of the two herbs...
  56. Wang D, Li D, Zhu W, Peng P. A new C-methylated homoisoflavanone and triterpenoid from the rhizomes of Polygonatum odoratum. Nat Prod Res. 2009;23:580-9 pubmed publisher
    ..and one known 9,19-cyclolart triterpenoid were isolated and characterised from the rhizomes of Polygonatum odoratum...
  57. Xian Y, Lin Z, Xu X, Su Z, Chen J, Lai X, et al. Effect of Rhizoma Polygonati on 12-O-tetradecanoylphorbol-acetate-induced ear edema in mice. J Ethnopharmacol. 2012;142:851-6 pubmed publisher
    Rhizoma Polygonati is originated from the dried rhizomes of Polygonatum sibircum Red. It has long been used in traditional Chinese medicine for the treatment of inflammatory disorders.
  58. Guitian J, Medrano M, Oti J. Variation in floral sex allocation in Polygonatum odoratum (Liliaceae). Ann Bot. 2004;94:433-40 pubmed
    ..The purpose of this study was to investigate variations in sexual investment at different levels (flower, plant and population) in Polygonatum odoratum, a plant with sequentially opening flowers.
  59. Liu B, Peng H, Yao Q, Li J, Van Damme E, Balzarini J, et al. Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities. Phytomedicine. 2009;16:601-8 pubmed publisher
    In the present study, three typical monocot mannose-binding lectins (e.g., Polygonatum cyrtonema lectin [PCL], Ophiopogon japonicus lectin [OJL] and Liparis noversa lectin [LNL]), were reported to possess a similar tertiary structure ..
  60. Zhang J, Ma B, Kang L, Yu H, Yang Y, Yan X, et al. Furostanol saponins from the fresh rhizomes of Polygonatum kingianum. Chem Pharm Bull (Tokyo). 2006;54:931-5 pubmed
    Ten furostanol saponins were isolated as five pairs of 25R and 25S epimers from the fresh rhizomes of Polygonatum kingianum...
  61. Wong L, Liang Z, Chen H, Zhao Z. Authentication of Chinese Materia Medica decoction dregs. Part II: comparison before and after decoction of four Chinese Materia Medica that mainly comprise storage tissue. Microsc Res Tech. 2012;75:164-75 pubmed publisher
    ..These differences could be used to authenticate CMM dregs...
  62. Meng L, Geng Z, Yin J, Wang H, Ji P. [Chemical properties and enzyme activities of rhizosphere and non-rhizosphere soils under six Chinese herbal medicines on Mt. Taibai of Qinling Mountains, Northwest China]. Ying Yong Sheng Tai Xue Bao. 2012;23:2685-92 pubmed
    ..soils in different habitats of six Chinese herbal medicines, including Pyrola decorata, Cephalotaxus fortunei, Polygonatum odoratum, Potentilla glabra, Polygonum viviparum, and Potentilla fruticosa, on the Mt...
  63. Ding J, Bao J, Zhu D, Zhang Y, Wang D. Crystallization and preliminary x-ray diffraction analysis of a novel mannose-binding lectin with antiretroviral properties from Polygonatum cyrtonema hua. Protein Pept Lett. 2008;15:411-4 pubmed
    A novel antiretroviral protein Polygonatum cyrtonema lectin (PCL) belonging to the monocot mannose-binding lectin (MMBL) superfamily has been crystallized using hanging-drop vapor-diffusion method. The crystals diffract to 2...
  64. Fu L, Zhou C, Yao S, Yu J, Liu B, Bao J. Plant lectins: targeting programmed cell death pathways as antitumor agents. Int J Biochem Cell Biol. 2011;43:1442-9 pubmed publisher
    ..these above-mentioned lectins, we demonstrate that mistletoe lectins (MLs), Ricin, Concanavalin A (ConA) and Polygonatum cyrtonema lectin (PCL) can lead to cancer cell programmed death via targeting apoptotic pathways...
  65. Yang Q, Yang C. Cytotoxic steroidal saponins from Polygonatum punctatum. Chem Biodivers. 2006;3:1349-55 pubmed
    Four new steroidal saponins, polypunctosides A-D (1-4, resp.), were isolated from the rhizomes of Polygonatum punctatum, together with five known steroidal saponins...
  66. Wu B, Hogetsu T, Isobe K, Ishii R. Community structure of arbuscular mycorrhizal fungi in a primary successional volcanic desert on the southeast slope of Mount Fuji. Mycorrhiza. 2007;17:495-506 pubmed publisher
    ..The inconsistencies in the species composition of spore communities with those in roots and the change in species diversity with altitude are discussed...
  67. Dong W, Shi H, Ma H, Miao Y, Liu T, Wang W. Homoisoflavanones from Polygonatum odoratum rhizomes inhibit advanced glycation end product formation. Arch Pharm Res. 2010;33:669-74 pubmed publisher
    Protein glycation inhibitors from Polygonatum odoratum rhizomes were investigated using a bioassay-guided procedure to characterize active compounds for preventing and treating diabetic complications...
  68. Ding J, Bao J, Zhu D, Zhang Y, Wang D. Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure. J Struct Biol. 2010;171:309-17 pubmed publisher
    b>Polygonatum cyrtonema lectin (PCL) is a novel anti-HIV mannose-binding lectin from Galanthus nivalis agglutinin (GNA)-related lectin family...
  69. Xu D, Hu C, Zhang Y. Two new steroidal saponins from the rhizome of Polygonatum sibiricum. J Asian Nat Prod Res. 2009;11:1-6 pubmed publisher
    ..A (1) and B (2), along with three known compounds, were obtained from the ethanolic extract of the rhizome of Polygonatum sibiricum Redoute...
  70. Coppini G, Diciotti S, Falchini M, Villari N, Valli G. Neural networks for computer-aided diagnosis: detection of lung nodules in chest radiograms. IEEE Trans Inf Technol Biomed. 2003;7:344-57 pubmed
    ..7-98.0%. When the second data set was used comparable results were obtained. The observed system performances support the undertaking of system validation in clinical settings...
  71. Khan H, Saeed M, Mehmood M, Rehman N, Muhammad N, Haq I, et al. Studies on tracheorelaxant and anti-inflammatory activities of rhizomes of Polygonatum verticillatum. BMC Complement Altern Med. 2013;13:197 pubmed publisher
    The present study describes the tracheorelaxant and anti-inflammatory effects of Polygonatum verticillatum which may support its medicinal use in hyperactive airway complaints and inflammatory disorders.
  72. Liu B, Xu X, Cheng Y, Huang J, Liu Y, Liu Z, et al. Apoptosis-inducing effect and structural basis of Polygonatum cyrtonema lectin and chemical modification properties on its mannose-binding sites. BMB Rep. 2008;41:369-75 pubmed
    b>Polygonatum cyrtonema Lectin (PCL), which is classified as a monocot mannose-binding lectin, has received great regards for its uniquely biological activities and potentially medical applications in cancer cells...
  73. Wu S, Li Y, Wu X. [Effect of polygona-polysaccharids on atheromatous plaque: experiment with rabbits]. Zhonghua Yi Xue Za Zhi. 2008;88:127-30 pubmed
    ..To study the effect of polygona-polysaccharids on the elimination of atheromatous plaque...
  74. Wang J, Lu C, Liu D, Xu Y, Zhu Y, Wu H. Constituents from Polygonatum sibiricum and their inhibitions on the formation of advanced glycosylation end products. J Asian Nat Prod Res. 2016;18:697-704 pubmed publisher
    ..1), together with twelve known compounds, were isolated from the rhizomes of Polygonatum sibiricum. The structures of these compounds were elucidated by analysis of their 1D/2D NMR and MS data...
  75. Khan H, Saeed M, Muhammad N, Khan F, Ibrar M, Hassan S, et al. Report: Comprehensive nutrients analysis of rhizomes of Polygonatum verticillatum. Pak J Pharm Sci. 2012;25:871-5 pubmed
    ..It is concluded that the extracts of rhizomes accumulated significant quantities of life indispensible nutrients and validated the ethnobotanical uses of the plant as tonic and energizer...
  76. Han S, Hu M, Qi G, Ma C, Wang Y, Ma F, et al. Polysaccharides from Polygonatum Inhibit the Proliferation of Prostate Cancer-Associated Fibroblasts. Asian Pac J Cancer Prev. 2016;17:3829-33 pubmed
    ..Polysaccharide extracted from polygonatum can selectively inhibit the growth of prostate-CAFs (<...
  77. Wang Y, Cheung Y, Yang Z, Chiu J, Che C, He Q. Proteomic approach to study the cytotoxicity of dioscin (saponin). Proteomics. 2006;6:2422-32 pubmed
    Dioscin, extracted from the root of Polygonatum zanlanscianense pamp, exhibits cytotoxicity towards human myeloblast leukemia HL-60 cells...
  78. Yu H, Ma B, Kang L, Zhang T, Jiang F, Zhang J, et al. Saponins from the processed rhizomes of Polygonatum kingianum. Chem Pharm Bull (Tokyo). 2009;57:1011-4 pubmed
    ..saponins, named kingianoside H (1) and kingianoside I (2), were isolated from the processed rhizomes of Polygonatum kingianum, along with a known triterpenoid saponin ginsenoside-Rc (3), four known spirostanol saponins Tg (4), (..
  79. Lei G, Feng W, Feng Y, Yang Y. [Quality standard of stewed rhizoma polygonati with yellow wine]. Zhong Yao Cai. 2011;34:1346-8 pubmed
    ..To improve the quality standard of stewed Rhizoma Polygonati with yellow wine...
  80. Tian Q, Zhao Z, Gu F. [Studies on phonological phases of cultivated Polygonatum]. Zhong Yao Cai. 2010;33:168-70 pubmed
    To determine the phonological phases of cultivated Polygonatum by investigating the dynamic pattern of its growth and development, which would provide the guides for normal planting in the field.
  81. Wu L, Liu T, Xiao Y, Li X, Zhu Y, Zhao Y, et al. Polygonatum odoratum lectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a-3p in human lung adenocarcinoma A549 cells. Int J Biol Macromol. 2016;85:217-26 pubmed publisher
    b>Polygonatum odoratum lectin (POL), a mannose-binding specific Galanthus nivalis agglutinin (GNA)-related lectin has been reported with remarkable anti-proliferative and apoptosis-inducing effects against several tumor cells...
  82. Hu C, Xu D, Wu Y, Ou S. Triterpenoid saponins from the rhizome of Polygonatum sibiricum. J Asian Nat Prod Res. 2010;12:801-8 pubmed publisher
    ..saponins, polygonoides C (1), D (2), and E (3), were obtained from the ethanolic extract of the rhizome of Polygonatum sibiricum Redoute...
  83. Liu Z, Luo Y, Zhou T, Zhang W. Could plant lectins become promising anti-tumour drugs for causing autophagic cell death?. Cell Prolif. 2013;46:509-15 pubmed publisher
    ..review, we provide a brief outline of structures of some representative plant lectins such as concanavalin A, Polygonatum cyrtonema lectin and mistletoe lectins...
  84. Park U, Jeong J, Jang J, Sung M, Youn H, Lee S, et al. Negative regulation of adipogenesis by kaempferol, a component of Rhizoma Polygonati falcatum in 3T3-L1 cells. Biol Pharm Bull. 2012;35:1525-33 pubmed
    ..Overall, our data suggests that kaempferol, a major component of RPF, may be beneficial in obesity, by reducing adipogenesis and balancing lipid homeostasis partly through the down-regulation of PPAR?...
  85. Zhong L, Zhang Y, Huo H, Gong Q. [Study on the composition and pharmacological function change of rhizoma polygonati before and after processing]. Zhong Yao Cai. 2011;34:1508-11 pubmed
    ..To discuss the processing mechanism of Rhizoma Polygonati (RP) through studying the correlation between the change of composition and pharmacological function in raw and processed RP...
  86. Li L, Ren F, Chen S, Gao Y. [New homoisoflavanones from Polygonatum odoratum (Mill.) Druce]. Yao Xue Xue Bao. 2009;44:764-7 pubmed
    To study chemical constituents of Polygonatum odoratum (Mill.) Druce, the compounds were separated with column chromatography and HPLC. On the basis of physicochemical properties and spectral data, their structures were confirmed...
  87. Chande N, Laidlaw M, Adams P, Marotta P. Yo Jyo Hen Shi Ko (YHK) improves transaminases in nonalcoholic steatohepatitis (NASH): a randomized pilot study. Dig Dis Sci. 2006;51:1183-9 pubmed
    ..YHK is well tolerated. Further studies are justified to assess the impact of YHK in the natural history of NASH...
  88. Qin H, Li Z, Wang P, Si L. [The new secondary metabolite from Polygonatum odoratum]. Zhongguo Zhong Yao Za Zhi. 2004;29:42-4 pubmed
    To investigate the chemical constituents of Polygonatum odoratum.
  89. Sun S, Zhang Z, Li S, Hu J, Zhang F. [Cloning, sequencing analysis and expression of a putative mannose-binding lectin gene from Polygonatum roseum in Xinjiang]. Sheng Wu Gong Cheng Xue Bao. 2008;24:387-94 pubmed
    The genomic DNA were extracted from the leaves of Polygonatum roseum (Liliaceae) in Xinjiang and the primers were designed according to conservative sequences of Polygonatum lectins gene...
  90. Wang Y, Lu C, Lai G, Cao J, Luo S. A new indolizinone from Polygonatum kingianum. Planta Med. 2003;69:1066-8 pubmed
    ..3-ethoxymethyl-5,6,7,8-tetrahydro-8-indolizinone (2) and isomucronulatol (3) were isolated from the rhizome of Polygonatum kingianum. Their structures were elucidated mainly on the basis of spectral data...