ophiopogon

Summary

Summary: A plant genus of the family Asparagaceae. Members contain steroidal glycosides and provide an ingredient of shengmaisan (DRUGS, CHINESE HERBAL).

Top Publications

  1. Cheng D, Yu Z, Pan P, Lin M, Chen Y. [Study on endophyte and the growth stages of Ophiopogon japonicus]. Zhong Yao Cai. 2006;29:205-6 pubmed
    To study on the relationship between the endophyte and the life cycle of Ophiopogon japonicus in Zhejiang...
  2. Lin X, Xu D, Feng Y, Shen L. Determination of Ophiopogon japonicus polysaccharide in plasma by HPLC with modified postcolumn fluorescence derivatization. Anal Biochem. 2005;342:179-85 pubmed
    ..antimyocardial ischemic activity of a graminan-type fructosan with an average molecular weight of 5,000 Da from Ophiopogon japonicus (FOJ-5) has necessitated the development of a sensitive and specific method to study its ..
  3. Xu D, Feng Y, Lin X, Deng H, Fang J, Dong Q. [Isolation, purification and structural analysis of a polysaccharide MDG-1 from Ophiopogon japonicus]. Yao Xue Xue Bao. 2005;40:636-9 pubmed
    To separate and purify the anti-myocardial ischemic polysaccharide fraction with a homogenous molecular weight from Ophiopogon japonicus, then study the chemical structure of the parts.
  4. Lin X, Xu D, Feng Y, Li S, Lu Z, Shen L. Release-controlling absorption enhancement of enterally administered Ophiopogon japonicus polysaccharide by sodium caprate in rats. J Pharm Sci. 2006;95:2534-42 pubmed
    The aim of this study was to improve the intestinal absorption of Ophiopogon japonicus polysaccharide (OJP) by incorporating it together with sodium caprate (SC) into erodible matrices, designed to release OJP and SC at various rates over ..
  5. Lin X, Wang Z, Sun G, Shen L, Xu D, Feng Y. A sensitive and specific HPGPC-FD method for the study of pharmacokinetics and tissue distribution of Radix Ophiopogonis polysaccharide in rats. Biomed Chromatogr. 2010;24:820-5 pubmed publisher
  6. Lin Y, Zhu D, Qi J, Qin M, Yu B. Characterization of homoisoflavonoids in different cultivation regions of Ophiopogon japonicus and related antioxidant activity. J Pharm Biomed Anal. 2010;52:757-62 pubmed publisher
    Homoisoflavonoids were identified in Ophiopogon japonicus of two cultivation regions in China: Hang-maidong (grown in Zhejiang province) and Chuan-maidong (grown in Sichuan province)...
  7. Liang H, Xing Y, Chen J, Zhang D, Guo S, Wang C. Antimicrobial activities of endophytic fungi isolated from Ophiopogon japonicus (Liliaceae). BMC Complement Altern Med. 2012;12:238 pubmed publisher
    ..b>Ophiopogon japonicus, containing compounds with antibacterial activity, is a traditional Chinese medicinal plant used for ..
  8. Wang Y, Yan T, Shen J, Guo H, Xiang X. Preventive effect of Ophiopogon japonicus polysaccharides on an autoallergic mouse model for Sjogren's syndrome by regulating the Th1/Th2 cytokine imbalance. J Ethnopharmacol. 2007;114:246-53 pubmed
    ..Currently, only palliative treatment is available. Ophiopogon japonicus, a common Chinese herbal, has been used to treat sicca-associated disorders in traditional Chinese ..
  9. Ma C, Li G, Zhang J, Zheng Q, Fan X, Wang Z. An efficient combination of supercritical fluid extraction and high-speed counter-current chromatography to extract and purify homoisoflavonoids from Ophiopogon japonicus (Thunb.) Ker-Gawler. J Sep Sci. 2009;32:1949-56 pubmed publisher
    Supercritical fluid extraction (SFE) was used to extract homoisoflavonoids from Ophiopogon japonicus (Thunb.) Ker-Gawler...

More Information

Publications120 found, 100 shown here

  1. Zheng Q, Feng Y, Xu D, Lin X, Chen Y. Influence of sulfation on anti-myocardial ischemic activity of Ophiopogon japonicus polysaccharide. J Asian Nat Prod Res. 2009;11:306-21 pubmed publisher
    b>Ophiopogon japonicus polysaccharide (FOJ-5) from Radix ophiopogonis has shown anti-myocardial ischemic action in vitro and in vivo in our previous studies...
  2. Hung T, Thu C, Dat N, Ryoo S, Lee J, Kim J, et al. Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity. Bioorg Med Chem Lett. 2010;20:2412-6 pubmed publisher
    Three new homoisoflavonoids (1-3) were isolated from the roots of Ophiopogon japonicus (Liliaceae). The structures of new metabolites were determined on the basis of spectroscopic analyses including 2D NMR...
  3. Lin X, Wang S, Jiang Y, Wang Z, Sun G, Xu D, et al. Poly(ethylene glycol)-radix Ophiopogonis polysaccharide conjugates: preparation, characterization, pharmacokinetics and in vitro bioactivity. Eur J Pharm Biopharm. 2010;76:230-7 pubmed publisher
    ..These findings demonstrate that PEGylation would be a promising approach for improving the clinical efficacy of ROP by prolonged retention in plasma...
  4. Lin X, Wang Z, Wang S, Shen L, Feng Y, Ruan K, et al. Comparison of tissue distribution of a PEGylated Radix Ophiopogonis polysaccharide in mice with normal and ischemic myocardium. Eur J Pharm Biopharm. 2011;79:621-6 pubmed publisher
    ..6, and 1.3 times, respectively, whereas it was increased by approximately 1.3-fold in the liver. The results of this study are highly instructive for the further pharmaceutical development of PEGylated ROP...
  5. Li N, Zhang J, Zeng K, Zhang L, Che Y, Tu P. Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus. Fitoterapia. 2012;83:1042-5 pubmed publisher
    ..1) and ophiopogonanone H (2), together with thirteen known ones (3-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analyses...
  6. Wang L, Wang Y, Xu D, Ruan K, Feng Y, Wang S. MDG-1, a polysaccharide from Ophiopogon japonicus exerts hypoglycemic effects through the PI3K/Akt pathway in a diabetic KKAy mouse model. J Ethnopharmacol. 2012;143:347-54 pubmed publisher
    b>Ophiopogon japonicus is a traditional Chinese medicine that might be helpful for the treatment of type 2 diabetes. Recent studies have confirmed its beneficial properties, but not the mechanism of action.
  7. Chen X, Tang J, Xie W, Wang J, Jin J, Ren J, et al. Protective effect of the polysaccharide from Ophiopogon japonicus on streptozotocin-induced diabetic rats. Carbohydr Polym. 2013;94:378-85 pubmed publisher
    The present study was designed to investigate the effect of OJP1, a polysaccharide isolated from the roots of Ophiopogon japonica, on blood lipid metabolism, antioxidant activity, as well as its protective effect on the liver and kidneys ..
  8. Wang Y, Xu J, Qu H. Structure characterization and identification steroidal saponins from Ophiopogon japonicus Ker-Gawler (Liliaceae) by high-performance liquid chromatography with ion trap mass spectrometry. Phytochem Anal. 2011;22:166-71 pubmed publisher
    Steroidal saponins are the main active constituents in Ophiopogon japonicus Ker-Gawler (Liliaceae)...
  9. Chen X, Zhao Z, Chen Y, Gou X, Zhou Z, Zhong G, et al. Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats. J Ethnopharmacol. 2016;192:362-369 pubmed publisher
    ..Mazz., Panax ginseng C.A. Mey, Ophiopogon japonicas (Thunb.) Ker-Gawl. and Schisandra chinensis (Turcz.) Baill...
  10. Lan S, Yi F, Shuang L, Chenjie W, Zheng X. Chemical constituents from the fibrous root of Ophiopogon japonicus, and their effect on tube formation in human myocardial microvascular endothelial cells. Fitoterapia. 2013;85:57-63 pubmed publisher
    ..cardiovascular system, a systematic study on macroporous resin adsorption of extracts from the fibrous root of Ophiopogon japonicus was performed in a human myocardial microvascular endothelial cell line (HMMEC) based assay...
  11. Fan Y, Ma X, Ma L, Zhang J, Zhang W, Song X. Antioxidative and immunological activities of ophiopogon polysaccharide liposome from the root of Ophiopogon japonicus. Carbohydr Polym. 2016;135:110-20 pubmed publisher
    The antioxidative and immunoregulatory activities of ophiopogon polysaccharide liposome (OPL) were investigated...
  12. Zhang W, Zhang Q, Jiang Y, Li F, Xin H. Effects of ophiopogonin B on the proliferation and apoptosis of SGC?7901 human gastric cancer cells. Mol Med Rep. 2016;13:4981-6 pubmed publisher
    Ophiopogonin B (OP?B) is a bioactive component of Radix Ophiopogon japonicus, which is often used in traditional Chinese medicine to treat cancer. The present study aimed to investigate the antitumor activity of OP?B in gastric cancer...
  13. Chen J, Yuan J, Zhou L, Zhu M, Shi Z, Song J, et al. Regulation of different components from Ophiopogon japonicus on autophagy in human lung adenocarcinoma A549Cells through PI3K/Akt/mTOR signaling pathway. Biomed Pharmacother. 2017;87:118-126 pubmed publisher
    ..b>Ophiopogon japonicus (L...
  14. Guo Y, Liu Y, Kang L, Zhang T, Yu H, Zhao Y, et al. Two novel furostanol saponins from the tubers of Ophiopogon japonicus. J Asian Nat Prod Res. 2013;15:459-65 pubmed publisher
    Phytochemical investigation of the fresh tubers of Ophiopogon japonicus led to the isolation of two new furostanol saponins (1 and 2) together with two known steroidal saponins (3 and 4)...
  15. Zhang W, Zhi D, Ren H, Wang D, Wang X, Zhang Z, et al. Shengmai Formula Ameliorates Pathological Characteristics in AD C. elegans. Cell Mol Neurobiol. 2016;36:1291-1302 pubmed
    Shengmai (SM) formula, a classical traditional Chinese medicine formula, is composed of Panax ginseng (Pg), Ophiopogon japonicus (Oj), and Schisandra Chinesis (Sc)...
  16. Gong Y, Zhang J, Gao F, Zhou J, Xiang Z, Zhou C, et al. Structure features and in vitro hypoglycemic activities of polysaccharides from different species of Maidong. Carbohydr Polym. 2017;173:215-222 pubmed publisher
    ..Liriope spicata polysaccharide (LSP), Ophiopogon japonicus polysaccharide (OJP) and Liriope muscari polysaccharide (LMP) were composed of ?-fructose and ?-..
  17. Zhang Z, Peng H, Li C, Liu J, Zhou T, Yan Y, et al. Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspase-dependent pathway as compared to Ophiopogon japonicus lectin. Phytomedicine. 2010;18:25-31 pubmed publisher
    ..In this study, we showed that Polygonatum cyrtonema lectin (PCL) and Ophiopogon japonicus lectin (OJL), the two mannose-binding GNA-related lectins, could induce murine fibrosarcoma L929 cell ..
  18. Zhang H, Xu T, Gao L, Liu X, Liu J, Yu B. A Novel Fluoroimmunoassay for Detecting Ruscogenin with Monoclonal Antibodies Conjugated with CdSe/ZnS Quantum Dots. Molecules. 2017;22: pubmed publisher
    Ruscogenin (RUS) is a steroidal sapogenin found in Ruscus aculeatus and Ophiopogon japonicus with several pharmacological activities...
  19. He Z, Lu X, Qu B. [Protective effects of shenmai injection on the delayed injury of the cerebral neurons in rat induced by intracerebral hemorrhage]. Zhongguo Zhong Yao Za Zhi. 2005;30:526-30 pubmed
    ..SM injection might attenuate the delayed injury induced by intracerebral hemorrhage via regulating the expression of PDGF. ..
  20. Wang L, Jiang X, Zhang W, Li F, Khan A, Liu X, et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogon japonicus. Phytochemistry. 2017;136:125-132 pubmed publisher
    Phytochemical investigation of the tubers of Ophiopogon japonicus led to the isolation of five previously undescribed steroidal saponins, ophiojaponins A-E, together with twelve known ones...
  21. Kou J, Yu B, Xu Q. Inhibitory effects of ethanol extract from Radix Ophiopogon japonicus on venous thrombosis linked with its endothelium-protective and anti-adhesive activities. Vascul Pharmacol. 2005;43:157-63 pubmed
    The in-vivo inhibitory effects of the ethanol extract of Radix Ophiopogon japonicus (ROJ-ext) on venous thrombosis were studied in mouse and rat models and in-vitro endothelial cell-protective and anti-adhesive activities were observed in ..
  22. Liu C, Ju A, Zhou D, Li D, Kou J, Yu B, et al. Simultaneous Qualitative and Quantitative Analysis of Multiple Chemical Constituents in YiQiFuMai Injection by Ultra-Fast Liquid Chromatography Coupled with Ion Trap Time-of-Flight Mass Spectrometry. Molecules. 2016;21: pubmed publisher
    ..However, its chemical composition has not been fully elucidated, particularly for the preparation derived from Ophiopogon japonicus...
  23. Wang X, Shi L, Joyce S, Wang Y, Feng Y. MDG-1, a Potential Regulator of PPARα and PPARγ, Ameliorates Dyslipidemia in Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..MDG-1, a β-d-fructan polysaccharide extracted from Ophiopogon japonicus, has been shown to improve abnormal blood lipid levels and alleviate diabetes...
  24. Liu B, Peng H, Yao Q, Li J, Van Damme E, Balzarini J, et al. Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities. Phytomedicine. 2009;16:601-8 pubmed publisher
    In the present study, three typical monocot mannose-binding lectins (e.g., Polygonatum cyrtonema lectin [PCL], Ophiopogon japonicus lectin [OJL] and Liparis noversa lectin [LNL]), were reported to possess a similar tertiary structure with ..
  25. Koyama R, Matsumoto A, Inahashi Y, Omura S, Takahashi Y. Isolation of actinomycetes from the root of the plant, Ophiopogon japonicus, and proposal of two new species, Actinoallomurus liliacearum sp. nov. and Actinoallomurus vinaceus sp. nov. J Antibiot (Tokyo). 2012;65:335-40 pubmed publisher
    Actinomycete strains K10-0485(T) and K10-0528(T) were isolated from the roots of Ophiopogon japonicus collected in Yokohama, Kanagawa Prefecture, Japan...
  26. Cao G, Jiang N, Hu Y, Zhang Y, Wang G, Yin M, et al. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci. 2016;17: pubmed publisher
    Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, has been shown to inhibit cerebral ischemic injury...
  27. Lin X, Lu Z, Xu D, Feng Y. [Comparison of distribution of Ophiopogon japonicas polysaccharide in hearts of normal rats and myocardial ischemic rats]. Zhongguo Zhong Yao Za Zhi. 2009;34:230-3 pubmed
    To investigate the distribution of Ophiopogon Japonicas polysaccharide (OJP) in hearts of normal rats and myocardial ischemic rats, and obtain the further evidences for determining the mechanism of its anti-myocardial ischemia...
  28. Yue L, Zhu D, Yan Y, Yu B. [Relationship between components changes and efficacy of Shengmaisan VII. Chemical dynamic change of schisandrin in Shengmaisan]. Zhongguo Zhong Yao Za Zhi. 2006;31:1010-2 pubmed
    ..To extract Schisandra chinensis with ginseng, ophiopogon, general ginsenoside or ginsenoside Rg1 could promote the content of schisandrin...
  29. Zhang J, Chen J, Wang D, Hu Y, Zhang C, Qin T, et al. Immune-enhancing activity comparison of sulfated ophiopogonpolysaccharide and sulfated jujube polysaccharide. Int J Biol Macromol. 2013;52:212-7 pubmed publisher
    ..These results indicated that sulfation modification could enhance the immune-enhancing activity of OPS and JPS, sOPS(80) possessed the best efficacy and would be expected as a component drug of new-type immunopotentiator. ..
  30. Haijiang Z, Yongjiang W, Yiyu C. Analysis of 'SHENMAI' injection by HPLC/MS/MS. J Pharm Biomed Anal. 2003;31:175-83 pubmed
    An HPLC/MS/MS method was developed for the analysis of 'SHENMAI' injection, composed of red ginseng and ophiopogon. The constituents of 'SHENMAI' were found to be similar with those of ginseng and 39 ginsenosides were detected...
  31. Duan C, Ma X, Jiang Y, Liu J, Tu P. Two new furostanol glycosides from the fibrous root of Ophiopogon japonicus (Thunb.) Ker-Gawl. J Asian Nat Prod Res. 2010;12:745-51 pubmed publisher
    Two new furostanol glycosides, ophiopogonins H (1) and I (2), were isolated from the fibrous root of Ophiopogon japonicus...
  32. Liu C, Qi J, Zhou D, Ju A, Yu B. Influence of ultrafiltration membrane on ophiopogonins and homoisoflavonoids in Ophiopogon japonicus as measured by ultra-fast liquid chromatography coupled with ion trap time-of-flight mass spectrometry. Chin J Nat Med. 2017;15:121-141 pubmed publisher
    ..In this work, Ophiopogon japonicus (L.f) Ker-Gawl...
  33. Zhang Y, Xi M, Choi Y, Lee B. Antithrombotic Effect of Fermented Ophiopogon japonicus in Thrombosis-Induced Rat Models. J Med Food. 2017;20:637-645 pubmed publisher
    In this study, the antithrombotic and thrombolytic ability of second fermented extract of Ophiopogon japonicus (FEOJ) was verified in thrombosis-induced rats. Thrombosis was induced by oral administration of 2% carrageenan for 4 weeks...
  34. Liu H, Wang Y, Wang T, Ying X, Wu R, Chen H. De novo assembly and annotation of the Zhe-Maidong (Ophiopogon japonicus (L.f.) Ker-Gawl) transcriptome in different growth stages. Sci Rep. 2017;7:3616 pubmed publisher
    Zhe-Maidong (Ophiopogon japonicus (L.f.) Ker-Gawl) is a traditional medicinal herb in the family Liliaceae that has significant pharmacological effects on immunity and cardiovascular disease...
  35. Lin M, Cheng D, Ding Z, Chen Y, Pan P. [Study on tissue culture technique of Liriope spicata]. Zhong Yao Cai. 2004;27:893-4 pubmed
    ..To study the tissue culture technique of Liriope spicata...
  36. Huang B, Yao C, Bian Q, Wang Z, Mo J. [Determination of diosgenin and ruscogenin in Radix Ophiopogonis by nonaqueous capillary electrophoresis]. Yao Xue Xue Bao. 2011;46:443-6 pubmed
    ..018 mg x g(-1) and ruscogenin was 0.008 mg x g(-1). The average recoveries of diosgenin and ruscogenin were 102% and 99.2%, respectively. A new method of the quality control of diosgenin and ruscogenin in Radix Ophiopogonis is provided. ..
  37. O Brien D, Morris M, Lee M, Tai S, King M. Ophiopogon root (Radix Ophiopogonis) prevents ultra-structural damage by SO2 in an epithelial injury model for studies of mucociliary transport. Life Sci. 2004;74:2413-22 pubmed
    We studied the action of the herb, Ophiopogon root (OR) in a epithelial injury model, hypothesizing that it may have beneficial effects on mucociliary transport following injury to the palate induced by sodium metabisulphite (MB) which ..
  38. Mao C, Xie H, Chen S, Valverde B, Qiang S. Multiple mechanism confers natural tolerance of three lilyturf species to glyphosate. Planta. 2016;243:321-35 pubmed publisher
    ..Here, the basis for natural tolerance to glyphosate in three lilyturf species, Ophiopogon japonicus (OJ), Liriope spicata (LS), and Liriope platyphylla (LP), is characterized...
  39. Fan Y, Ma X, Hou W, Guo C, Zhang J, Zhang W, et al. The adjuvanticity of ophiopogon polysaccharide liposome against an inactivated porcine parvovirus vaccine in mice. Int J Biol Macromol. 2016;82:264-72 pubmed publisher
    In this study, the adjuvant activity of ophiopogon polysaccharide liposome (OPL) was investigated. The effects of OPL on the splenic lymphocyte proliferation of mice were measured in vitro...
  40. Li G, Park Y. SCAR markers for discriminating species of two genera of medicinal plants, Liriope and Ophiopogon. Genet Mol Res. 2012;11:2987-96 pubmed
    The development of DNA markers that can closely discriminate between Liriope and Ophiopogon species is vital for efficient and accurate identification of these species, and to ensure the quality, safety, and efficacy of medicines made ..
  41. Hatier J, Clearwater M, Gould K. The functional significance of black-pigmented leaves: photosynthesis, photoprotection and productivity in Ophiopogon planiscapus 'Nigrescens'. PLoS ONE. 2013;8:e67850 pubmed publisher
    ..The data indicate a light-screening, photoprotective role of foliar anthocyanins. However, limitations to photosynthetic carbon assimilation are relatively small, insufficient to explain the natural scarcity of black-leafed plants. ..
  42. Chen S, Li X, Liu L, Liu C, Han X. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. FASEB J. 2018;32:1139-1153 pubmed publisher
    ..Ophiopogonin D (OP-D), a steroidal glycoside and an active component extracted from the root of the plant Ophiopogon japonicus (also known as radix ophiopogonis), can regulate multiple physiologic processes...
  43. Xia C, Sun J, Wang G, Shang L, Zhang X, Zhang R, et al. Herb-drug interactions: in vivo and in vitro effect of Shenmai injection, a herbal preparation, on the metabolic activities of hepatic cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in rats. Planta Med. 2010;76:245-50 pubmed publisher
    ..9 %, respectively. These in vivo and in vitro results demonstrated that SMI had the potential to inhibit the activities of hepatic CYP3A1/2 and CYP2C6, but might not significantly affect CYP1A2 and CYP2E1-mediated metabolism in rats. ..
  44. Leong P, Chen N, Chiu P, Leung H, Ma C, Tang Q, et al. Long-term treatment with shengmai san-derived herbal supplement (Wei Kang Su) enhances antioxidant response in various tissues of rats with protection against carbon tetrachloride hepatotoxicity. J Med Food. 2010;13:427-38 pubmed publisher
    ..Long-term WKS treatment may prevent diseases by enhancing the resistance of mitochondria to oxidative stress. ..
  45. Qu Y, Zhang Y, Pei L, Wang Y, Gao L, Huang Q, et al. New neuritogenic steroidal saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl. Biosci Biotechnol Biochem. 2011;75:1201-4 pubmed
    A new steroidal saponin was isolated from Ophiopogon japonicus. This saponin possesses a modification by 2-hydroxy-3-methylvalerylation of the hydroxyl group at C-4' of the sugar, linked to C-1 of the aglycone...
  46. Zhu Y, Cong W, Shen L, Wei H, Wang Y, Wang L, et al. Fecal metabonomic study of a polysaccharide, MDG-1 from Ophiopogon japonicus on diabetic mice based on gas chromatography/time-of-flight mass spectrometry (GC TOF/MS). Mol Biosyst. 2014;10:304-12 pubmed publisher
    ..b>Ophiopogon japonicus is a traditional Chinese medicine used to treat diabetes for thousands of years...
  47. Liu J, Liu S, Chen X, Zhang S, Zou Y. [Comprehensive comparison between erective and creepy Ophiopogon japonicus of Sichuan]. Zhongguo Zhong Yao Za Zhi. 2009;34:2449-53 pubmed
    ..characters, HPLC fingerprints, the content of main component and amino acid between erective and creepy Ophiopogon japonicus of Sichuan...
  48. Wu B, Liu P, Gao Y, Wang Y. [Effect of water extract from traditional Chinese medicines Rehmannia glutinosa, Scrophularia ningpoensis, Asparagus cochinchinensis and Ophiopogon japonicas on contents of CYP450 and activities of CYP3A, CYP2E1 and CYP1A2 in rat]. Zhongguo Zhong Yao Za Zhi. 2011;36:2710-4 pubmed
    ..the effects of the water extract of Rehmannia glutionsa, Scrophularia ningpoensis, Asparagus cochinchinensis and Ophiopogon japonicas, which are the drug from Tianwang Buxin Wan from nourishing vin, on the content of cytohrome P450 (..
  49. Xie T, Liang Y, Hao H, A J, Xie L, Gong P, et al. Rapid identification of ophiopogonins and ophiopogonones in Ophiopogon japonicus extract with a practical technique of mass defect filtering based on high resolution mass spectrometry. J Chromatogr A. 2012;1227:234-44 pubmed publisher
    ..The full-scan LC-MS/MS data of the Ophiopogon japonicus extract was acquired using high performance liquid chromatography coupled with hybrid quadrupole-time ..
  50. Hoang Anh N, Van Sung T, Porzel A, Franke K, Wessjohann L. Homoisoflavonoids from Ophiopogon japonicus Ker-Gawler. Phytochemistry. 2003;62:1153-8 pubmed
    From the ethyl acetate extract of the tuberous roots of Ophiopogon japonicus (Liliaceae) eight known and five new homoisoflavonoidal compounds were isolated...
  51. Ye M, Guo D, Ye G, Huang C. Analysis of homoisoflavonoids in Ophiopogon japonicus by HPLC-DAD-ESI-MSn. J Am Soc Mass Spectrom. 2005;16:234-43 pubmed
    The homoisoflavonoids in Ophiopogon japonicus (Thunb.) Ker-Gawler were analyzed by high-performance liquid chromatography-diode array detection-electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MSn)...
  52. Dai H, Mei W. Ophiopojaponin D, a new phenylpropanoid glycoside from Ophiopogon japonicus Ker-Gawl. Arch Pharm Res. 2005;28:1236-8 pubmed
    ..D (1), together with two known compounds, was isolated from the tubers of a famous traditional Chinese herb-Ophiopogon japonicus Ker-Gawl...
  53. Liu J, Chen X, Liu S, Yang W, Du G, Liu W. [Evaluation of germplasm resource of Ophiopogon japonicus in Sichuan basin based on principal component and cluster analysis]. Zhongguo Zhong Yao Za Zhi. 2010;35:569-73 pubmed
    To compare and appraise the quality of germplasm resource of Ophiopogon japonicus in Sichuan basin. According to the main contents and yield traits, 24 wild germplasm resources of O...
  54. Zhu Y, Zhao M, Ren L, Tian D, Dou F, Wang J. [Studies on the chemical constituents from the flowers of Ophiopogon japonicus]. Zhong Yao Cai. 2011;34:720-3 pubmed
    To study the chemical constituents from the flowers of Ophiopogon japonicus. Column chromatography and spectral analysis were used to isolate and identify the constituents...
  55. Wang Q, Lu W, Lu H, Liu F, Yang S, Hua Y, et al. [Protective effect of qi dong yi xin on acute myocardial infarction in dogs]. Zhongguo Zhong Yao Za Zhi. 2003;28:449-52 pubmed
    ..0,2.0 mg.kg-1. QDYX can decrease cardial oxygen consumption in dogs, thus having protective effect on myocardial ischemia. ..
  56. Zhang L, Ye Z, Guo Q. [Effects of soil factor on active components of Radix Ophiopogonis]. Zhongguo Zhong Yao Za Zhi. 2010;35:1372-7 pubmed
    ..K, Fe, Mn, B, Ba, Zn of soil also had much influence on it then others inorganic elements. ..
  57. Zeng P, Zhou H, Zheng Y, Xu X, Fu S. [Simultaneous determination of three homoisoflavonoids in Ophiopogon japonicus by HPLC]. Zhongguo Zhong Yao Za Zhi. 2012;37:71-4 pubmed
    Three homoisoflavonoids, 6-aldehydo-3-ophiopogonanone A, methyl ophiopogonanone A and ophiopogonanone A from Ophiopogon japonicus were analyzed simultaneously by HPLC with acetonitrile-water containing 0...
  58. Wu L, Ding X, Zhu D, Yu B, Yan Y. Study on the radical scavengers in the traditional Chinese medicine formula shengmai san by HPLC-DAD coupled with chemiluminescence (CL) and ESI-MS/MS. J Pharm Biomed Anal. 2010;52:438-45 pubmed publisher
    ..This study demonstrated that HPLC-DAD-CL on-line assay was a useful technique for rapidly screening and identifying bioactive components from complex multi-herbal prescription. ..
  59. Zhang T, Zou P, Kang L, Yu H, Liu Y, Song X, et al. Two novel furostanol saponins from Ophiopogon japonicus. J Asian Nat Prod Res. 2009;11:824-31 pubmed publisher
    Two novel furostanol saponins were isolated from the fresh tubers of Ophiopogon japonicus...
  60. Han X, Ye Y, Guo B, Liu S. [Effects of platycodin D in combination with different active ingredients of Chinese herbs on proliferation and invasion of 4T1 and MDA-MB-231 breast cancer cell lines]. Zhong Xi Yi Jie He Xue Bao. 2012;10:67-75 pubmed
    ..The effective doses of platycodin D, Ophiopogon total saponins, curcumenol and osthole in inhibiting proliferation of breast cancer cell lines 4T1 and MDA-MB-..
  61. Li P, Lin W, Wang Y, Peng W, Cai X, Su W. Antidiabetic activities of oligosaccharides of Ophiopogonis japonicus in experimental type 2 diabetic rats. Int J Biol Macromol. 2012;51:749-55 pubmed publisher
    ..This study demonstrates, for the first time to our knowledge, that OOJ exerts remarkable antidiabetic effect in experimental type 2 diabetes mellitus, thus justifying its traditional usage. ..
  62. Lin Y, Wu C, Lin C, Hsieh M. The ameliorating effects of cognition-enhancing Chinese herbs on scopolamine- and MK-801-induced amnesia in rats. Am J Chin Med. 2003;31:543-9 pubmed
    The study was to investigate the ameliorating effects of three Chinese herbs--Achyranthes bidentata (AB), Ophiopogon japonicus (OJ) and Cnidium monnieri (CM) on scopolamine (SCOP)- and MK-801-induced amnesia by using a passive avoidance ..
  63. Wang Y, Liang Z, Li Q, Yang H, Chen H, Zhao Z, et al. Identification of powdered Chinese herbal medicines by fluorescence microscopy, Part 1: Fluorescent characteristics of mechanical tissues, conducting tissues, and ergastic substances. Microsc Res Tech. 2011;74:269-80 pubmed publisher
    ..Hence, fluorescence microscopy could be a useful additional method for the authentication of powdered CHMs if the fluorescent characteristics of specific CHMs are known...
  64. Wang Z, Lin X, Shen L, Feng Y, Xu D, Ruan K. [Pharmacokinetics of a long-circulating PEGylated Radix Ophiopogonis polysaccharide]. Yao Xue Xue Bao. 2011;46:1257-61 pubmed
    ..1 h, increased 2.4 times compared to those of iv administration. In general, linear pharmacokinetics was observed for the conjugate within the dose range studied, and sc should be a promising administration route for the conjugate. ..
  65. Chang J, Shen C, Huang Y, Chien M, Ou J, Shieh B, et al. Five new homoisoflavonoids from the tuber of Ophiopogon japonicus. J Nat Prod. 2002;65:1731-3 pubmed
    ..E (4) and ophiopogonanone F (5), and six known compounds were isolated from an ethanol extract of the tubers of Ophiopogon japonicus (Thunb) Ker-Gawl. Spectroscopic analyses were used to elucidate the structures of these compounds.
  66. Xu M, Wang G, Xie H, Huang Q, Wang W, Jia Y. Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus Schisandrae aqueous extract and Sheng-Mai-San to rats. J Ethnopharmacol. 2008;115:483-8 pubmed
    ..A. Mey., Araliaceae), Radix Ophiopogonis (Ophiopogon japonicus (Thunb.) Ker-Gawl., Liliaceae) and Fructus Schisandrae (Schisandra chinensis (Turcz.) Baill...
  67. Zheng Q, Feng Y, Xu D. [Protective effect of Ophiopogonis polysaccharide MDG-1 on experimental myocardial ischemic rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27:1116-20 pubmed
    ..To investigate the protective effect of Ophiopogonis polysaccharide (MDG-1) on isolated myocardium ischemia/reperfusion injury (IRI) and subcutaneous injection of isoprenaline induced acute myocardial ischemia...
  68. Ding X, Chen G, Liu Y. [Effects of shengmai for injection on cardiogenic shock]. Zhongguo Zhong Yao Za Zhi. 2007;32:2298-305 pubmed
    ..To study the protective effects and the possible mechanism of shengmai for injection(SM) against the experimental acute cardiogenic shock...
  69. Xia C, Sun J, Hao H, Wang G, Yan B, Gu S, et al. Quantitative determination of ophiopogonin d by liquid chromatography/electrospray ionization mass spectrometry and its pharmacokinetics in rat. Planta Med. 2008;74:1832-6 pubmed publisher
    ..007 +/- 0.002 L/min/kg) for the latter formulation, consistent with an inhibition by one or more other components in the formulation...
  70. Li N, Zhang L, Zeng K, Zhou Y, Zhang J, Che Y, et al. Cytotoxic steroidal saponins from Ophiopogon japonicus. Steroids. 2013;78:1-7 pubmed publisher
    ..named ophiopogonin P-S (1-4), together with eleven known ones (5-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analysis...
  71. Wang J, Liu H, Liu L, Tang H, Zhang P, Tang Y. [Development of full-quantified HPLC fingerprint for quality evaluation of ophiopogonis radix of sichuan]. Zhong Yao Cai. 2013;36:721-5 pubmed
    ..To establish HPLC fingerprint of Ophiopogonis Radix of Sichuan and simultaneously determine two homoisoflavonoids (methylophiopogonanones A and B)...
  72. Cheng Z, Wu T, Bligh S, Bashall A, Yu B. cis-Eudesmane sesquiterpene glycosides from Liriope muscari and Ophiopogon japonicus. J Nat Prod. 2004;67:1761-3 pubmed
    ..liriopeoside A (1) and ophiopogonoside A (2), were extracted and purified from tubers of Liriope muscari and Ophiopogon japonicus, respectively, along with three known compounds...
  73. Shen L, Xu D, Feng Y, Li X, Wu X. [Effect of intestinal bacteria on metabolism of ophiopognin saponin D' in rats]. Zhongguo Zhong Yao Za Zhi. 2005;30:618-20 pubmed
    ..To explore the metabolic transformation and the absorbed metabolites of ophiopognin saponin D' (OD') given orally in rats...
  74. Chen X, Yagn W, Liu W. [Study on biological characteristics and relative yield of Ophiopogon japonicus]. Zhongguo Zhong Yao Za Zhi. 2006;31:1141-3 pubmed
    ..To study the biological characteristics and the relative yield of Ophiopgon japonicus...
  75. Lin X, Lu Z, Xu D, Feng Y, Shen L. [Oral absorption enhancers of Ophiopogon japonicas polysaccharides]. Zhongguo Zhong Yao Za Zhi. 2009;34:1498-502 pubmed
    To investigate suitable oral absorption enhancer (s) for Ophiopogon japonicas polysaccharides (OJP) and provide bases of utilizing the absorption enhancer to realize the oral administration of OJP.
  76. Duan C, Kang Z, Lin C, Jiang Y, Liu J, Tu P. Two new homoisoflavonoids from the fibrous roots of Ophiopogon japonicus (Thunb.) Ker-Gawl. J Asian Nat Prod Res. 2009;11:876-9 pubmed publisher
    Two new homoisoflavonoids ophiopogonone D (1) and ophiopogonanone G (2) were isolated from the fibrous roots of Ophiopogon japonicus...
  77. Qi J, Xu D, Zhou Y, Qin M, Yu B. New features on the fragmentation patterns of homoisoflavonoids in Ophiopogon japonicus by high-performance liquid chromatography/diode-array detection/electrospray ionization with multi-stage tandem mass spectrometry. Rapid Commun Mass Spectrom. 2010;24:2193-206 pubmed publisher
    ..to study the fragmentation behavior of 11 homoisoflavonoid standards and to analyze homoisoflavonoids in Ophiopogon japonicus. In total, 28 homoisoflavonoids (including seven novel constituents) were characterized...
  78. Xu J, Wang Y, Xu D, Ruan K, Feng Y, Wang S. Hypoglycemic effects of MDG-1, a polysaccharide derived from Ophiopogon japonicas, in the ob/ob mouse model of type 2 diabetes mellitus. Int J Biol Macromol. 2011;49:657-62 pubmed publisher
    b>Ophiopogon japonicus is a traditional Chinese medicine used to treat diabetes mellitus. We investigate the anti-ischemic properties of a water-soluble ?-D-fructan (MDG-1) from O. japonicus, and assess the antidiabetic effects of MDG-1...
  79. Wang H. Preventive effects of ophiopogon-polysaccharide on apiponectin in gestational diabetes mellitus rat. Asian Pac J Trop Med. 2013;6:296-9 pubmed publisher
    To investigate the effect of ophiopogon-polysaccharide on adiponectin (APN) in gestational diabetic mellitus rat. The model of gestational diabetes mellitus rat were established with streptozotocin by intraperitoneal injection...
  80. Bao Y, Jing C, Shi W. Effects of Chinese herbal recipes on immunity in immunosuppressive mice. Afr J Tradit Complement Altern Med. 2012;9:548-52 pubmed
    ..These results indicate that Chinese herbal medicine prescription can enhance humoral immunity and cellular immune function of the immunosuppressive mouse...
  81. She G, Shi J. [Structural features of two neutral polysaccharides Md-1, Md-2 from Ophiopogon japonocus]. Zhong Yao Cai. 2003;26:100-1 pubmed
    To study the chemical feature of Md-1, Md-2 polysaccharides which extracted from Ophiopogon japonocus.
  82. Chen X, Yang W, Liu H. [Study on N, P and K absorption and accumulation in Ophiopogon japonicus]. Zhongguo Zhong Yao Za Zhi. 2005;30:1233-6 pubmed
    ..To study the absorption and accumulation of N, P and K in Ophiopgon japonicus...
  83. Ito Y, Kanamaru A, Tada A. Effects of methylophiopogonanone B on melanosome transfer and dendrite retraction. J Dermatol Sci. 2006;42:68-70 pubmed
  84. Liu N, Wen X, Liu J, Liang M, Zeng H, Lin Y, et al. Determination of ruscogenin in crude Chinese medicines and biological samples by immunoassay. Anal Bioanal Chem. 2006;386:1727-33 pubmed
    Ruscogenin is a major bioactive steroidal aglycone found in the Chinese medicine, Ophiopogon japonicus...
  85. Wu X, Dai H, Huang L, Gao X, Tsim K, Tu P. A fructan, from Radix ophiopogonis, stimulates the proliferation of cultured lymphocytes: structural and functional analyses. J Nat Prod. 2006;69:1257-60 pubmed
    A fructan, Opaw-2, with molecular mass of about 14 kDa, was isolated from the tuberous roots of Ophiopogon japonicus. Opaw-2 comprises fructose and glucose with a molar ratio of 30:1...
  86. Lou Q, Xu R. [Determination of trace elements in radix ophiopogonis by HG-ICP-AES]. Guang Pu Xue Yu Guang Pu Fen Xi. 2007;27:1218-21 pubmed
    ..The result will provide scientific data for the study on the elements in radix ophiopogonis and on their relativity of medicine efficacy...
  87. Huang Y, Kou J, Ma L, Song J, Yu B. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. J Pharmacol Sci. 2008;108:198-205 pubmed
    ..RUS), first isolated from Ruscus aculeatus, also a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been found to exert significant anti-inflammatory and anti-thrombotic activities...
  88. Song J, Jeong G, Park S, Won S, Paek N, Lee B, et al. Inhibitory effects of fermented extract of Ophiopogon japonicas on thrombin-induced vascular smooth muscle cells. Mol Med Rep. 2016;13:426-32 pubmed publisher
    b>Ophiopogon japonicus is known to have various pharmacological effects. The present study investigated the effects of an extract of fermented Ophiopogon japonicas (FEOJ) on thrombin?treated vascular smooth muscle cells (VSMCs)...
  89. Ma L, Lei Y, Xue Q, Wang S, Yang D, Lu Z. [Effects of shenqifuxin oral liquid on the plasma kaliuretic peptide, the myocardial contractility and relaxation of left ventricle and the left ventricular remodeling in experimental rats with heart failure]. Zhongguo Zhong Yao Za Zhi. 2003;28:656-60 pubmed
  90. Liu Y, Yang L, Zeng X, Deng Y, Feng Y, Liang W. [Pharmacokinetics of ginsenosides Rg1 and Re in Shenmai injection]. Yao Xue Xue Bao. 2005;40:365-8 pubmed
    ..To study the pharmacokinetics of ginsenosides Rg1 and Re after iv infusion of Shenmai injection in human...
  91. Tang Q, Hu H, Zhang H. [Influence of Shenmai injection on blood serum tumor necrosis factor and bone marrow CD34+ cell's apoptosis of chronic aplastic anemia patient]. Zhongguo Zhong Yao Za Zhi. 2005;30:1296-8 pubmed
    ..To investigate the effect of Shenmai injection on chronic aplastic anemia patients and its mechanism...
  92. Xu T, Xu Y, Xie S, Zhao H, Han D, Li Y, et al. A novel steroidal glycoside, ophiofurospiside A from Ophiopogon japonicus (Thunb.) Ker-Gawl. J Asian Nat Prod Res. 2008;10:415-8 pubmed publisher
    ..ophiofurospiside A (1), was isolated together with the known steroidal glycosides 2, 3, and 4 from the tubers of Ophiopogon japonicus (Thunb.) Ker-Gawl...