liriope plant

Summary

Summary: A plant genus of the family Asparagaceae. Members contain ruscogenin. Do not confuse with the Liriope jellyfish (CNIDARIA).

Top Publications

  1. Jiang T, Huang B, Zhang Q, Han T, Zheng H, Qin L. [Effect of Liriope platyphylla total saponin on learning, memory and metabolites in aging mice induced by D-galactose]. Zhong Xi Yi Jie He Xue Bao. 2007;5:670-4 pubmed
    ..To investigate the effects of Liriope platyphylla total saponin (LPTS) on learning, memory, neuromediators and metabolites in aging mice induced by D-galactose...
  2. Zhou Q, Zhou J, Cheng J, Wang J, Chen J. [Cytological comparison of anther and pollen growth in Liriope spicata var. prolifera and L. spicata]. Zhong Yao Cai. 2009;32:1188-91 pubmed
    ..To compare the difference of anther and pollen growth between Liriope spicata var. prolifera and L. spicate, and investigate the mechanism of the sterility of Liriope spicata var. prolifera...
  3. Liu J, Chen T, Yu B, Xu Q. Ruscogenin glycoside (Lm-3) isolated from Liriope muscari inhibits lymphocyte adhesion to extracellular matrix. J Pharm Pharmacol. 2002;54:959-65 pubmed
    ..These results suggest that the blockade of lymphocyte adhesion to extracellular matrix through interference with the protein kinase C pathway may be one of the mechanisms by which Lm-3 exerts anti-inflammatory activity...
  4. Choi S, Wha J, Park S. The insulin sensitizing effect of homoisoflavone-enriched fraction in Liriope platyphylla Wang et Tang via PI3-kinase pathway. Life Sci. 2004;75:2653-64 pubmed
    ..GLUT4 translocation was increased through insulin receptor substrate 1 (IRS1)-PI3 kinase-Akt signaling mechanism. Thus, homoisoflavone-enriched fraction in LPWT extract played an important role as an insulin sensitizer in adipocytes...
  5. Lee Y, Kim J, Nam S, Goo J, Choi S, Choi Y, et al. Differential regulation of the biosynthesis of glucose transporters by the PI3-K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla. Int J Mol Med. 2011;27:319-27 pubmed publisher
    ..Thus, these results suggest the possibility that the LP9M80-H-induced regulation of Glut-1 and Glut-3 biosynthesis may be mediated by the Akt and p38 MAPK signaling of the insulin signaling pathway in the liver and brain of mice...
  6. Sun L, Lin S, Zhao R, Yu B, Yuan S, Zhang L. The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue factor. Biol Pharm Bull. 2010;33:1192-8 pubmed
    ..Our data suggest that DT-13 inhibits MDA-MB-435 cells metastasis during hypoxia via regulation of TF, and the effect of DT-13 on TF is partly mediated by Egr-1...
  7. Choi S, Goo J, Kim J, Nam S, Hwang I, Lee H, et al. Differential effects of the steaming time and frequency for manufactured red Liriope platyphylla on nerve growth factor secretion ability, nerve growth factor receptor signaling pathway and regulation of calcium concentration. Mol Med Rep. 2012;6:1160-70 pubmed publisher
    ..These results suggest the possibility that steaming-processed LP may aid in the relief of neurodegenerative diseases through the NGF secretion ability and NGF signaling pathway...
  8. Lin M, Cheng D, Ding Z, Chen Y, Pan P. [Study on tissue culture technique of Liriope spicata]. Zhong Yao Cai. 2004;27:893-4 pubmed
    ..To study the tissue culture technique of Liriope spicata...
  9. Chen X, Bai X, Liu Y, Tian L, Zhou J, Zhou Q, et al. Anti-diabetic effects of water extract and crude polysaccharides from tuberous root of Liriope spicata var. prolifera in mice. J Ethnopharmacol. 2009;122:205-9 pubmed
    ..var. prolifera Y. T. Ma, which is widely used in prescriptions of traditional Chinese medicine for the treatment of diabetes mellitus...

More Information

Publications44

  1. Han Y, Jung H, Lee D, Kwon S, Son K, Park Y. Anti-inflammatory effects of prosapogenin III from the dried roots of Liriope platyphylla in LPS-stimulated RAW264.7 cells. J Asian Nat Prod Res. 2013;15:1038-49 pubmed publisher
    ..These results indicate that prosapogenin III of Liriopis Tuber has anti-inflammatory effects in activated macrophages through inhibition of production of inflammatory mediators by blockade of the MAPK/NF-?B pathway. ..
  2. Lee H, Kim J, Goo J, Choi S, Hwang I, Lee Y, et al. Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats. Int J Mol Med. 2012;30:905-13 pubmed publisher
    ..The data presented here highlight the possibility that RLP can be considered a candidate for the prevention or alleviation of obesity-related diseases...
  3. Chen X, Liu Y, Bai X, Wen L, Fang J, Ye M, et al. Hypoglycemic polysaccharides from the tuberous root of Liriope spicata. J Nat Prod. 2009;72:1988-92 pubmed publisher
    ..These results suggest that LSP1 and LSP2 show high potential to be explored as natural oral hypoglycemic agents...
  4. Jiang C, Liu Z, Li L, Lin B, Yang F, Qin M. A new eudesmane sesquiterpene glycosides from Liriope muscari. J Asian Nat Prod Res. 2012;14:491-5 pubmed publisher
    ..Their structures were confirmed by 1D and 2D NMR spectroscopy. Among them, compounds 1, 2, 4, and 5 were the first reported from the genus Liriope. Ophiopogonoside B (1) showed moderate inhibitory activity to glycogen phosphorylase a...
  5. Ma S, Kou J, Yu B. Safety evaluation of steroidal saponin DT-13 isolated from the tuber of Liriope muscari (Decne.) Baily. Food Chem Toxicol. 2011;49:2243-51 pubmed publisher
    ..Necropsy, hematological and biochemical analysis, and histopathological examination did not reveal any remarkable and treatment related changes. In conclusion, DT-13 is of low toxicity at the tested doses...
  6. Zhang J, Chen R. [Genetic diversity of Liriope Muscari by TRAP analysis]. Zhongguo Zhong Yao Za Zhi. 2010;35:3108-13 pubmed
    ..Target region amplification polymorphism (TRAP) marker was occupied to study on the genetic diversity of fifty Liriope Muscari clones...
  7. Liu X, Liu Z, Yang M, Chen K. [Study on diversity of Liriope spicata var. prolifera and its affinis species with ISSR method]. Zhong Yao Cai. 2010;33:1052-5 pubmed
    ..To study the identification of Liriope spicata var. prolifera and its affinis species, which are difficult to be differentiated with routine method, based on ISSR molecular marker technology and explore their relationship...
  8. Zhou Q, Zhou J, Wang X, Wang J, Li J, Chen J. [Callus induction and plant regeneration of Liriope spicata var. prolifera anther]. Zhongguo Zhong Yao Za Zhi. 2009;34:2160-2 pubmed
    ..To study the technique of the callus induction from anther and plant regeneration of medicinal plants Liriope spicata var. prolifera...
  9. Zhang Y, Liu J, Kou J, Yu J, Yu B. DT-13 suppresses MDA-MB-435 cell adhesion and invasion by inhibiting MMP-2/9 via the p38 MAPK pathway. Mol Med Rep. 2012;6:1121-5 pubmed publisher
    ..In conclusion, the results suggest that DT-13 possesses anticancer and antimetastatic properties by inhibiting the invasion of cancer cells...
  10. Qiu C, Jozsef L, Yu B, Yu J. Saponin monomer 13 of dwarf lilyturf tuber (DT-13) protects serum withdrawal-induced apoptosis through PI3K/Akt in HUVEC. Biochem Biophys Res Commun. 2014;443:74-9 pubmed publisher
    ..Thus, DT-13 could improve survival of EC and therefore be a potential clinical use in the treatment of cardiovascular diseases. ..
  11. Kim M, Yoo Y, Sung N, Lee J, Park S, Shon E, et al. Anti-Inflammatory Effects of Liriope platyphylla in LPS-Stimulated Macrophages and Endotoxemic Mice. Am J Chin Med. 2016;44:1127-1143 pubmed
  12. Tsai Y, Chiang S, El Shazly M, Wu C, Beerhues L, Lai W, et al. The oestrogenic and anti-platelet activities of dihydrobenzofuroisocoumarins and homoisoflavonoids from Liriope platyphylla roots. Food Chem. 2013;140:305-14 pubmed publisher
    ..Several components exhibited significant oestrogenic and anti-platelet activities; demonstrating for the first time the potential use of L. platyphylla as a nutritional supplement for cardiovascular and endocrine diseases...
  13. Xiao Z, Wang Y, Yue Y, Zhang Y, Chen C, Wan L, et al. Preventive effects of polysaccharides from Liriope spicata var. prolifera on diabetic nephropathy in rats. Int J Biol Macromol. 2013;61:114-20 pubmed publisher
    ..In conclusion, LSP had potential preventive effects on diabetic nephropathy in diabetic rats. ..
  14. Li W, Zhang Z, Cheng X, Liu J, He Y, Zhou C, et al. Two new compounds isolated from Liriope muscari. Molecules. 2012;17:8773-81 pubmed publisher
    ..The structures of these compounds were elucidated and characterized on the basis of 1D NMR, 2D NMR, CD and MS data. The in vitro antioxidant activities of compounds 1-3 were assessed by the DPPH and ABTS scavenging methods...
  15. Kim J, Lee Y, Kwak M, Ko J, Hong J, Hwang D. Aqueous extracts of Liriope platyphylla induced significant laxative effects on loperamide-induced constipation of SD rats. BMC Complement Altern Med. 2013;13:333 pubmed publisher
    ..platyphylla (AEtLP)...
  16. Zhang H, Wang G, Bai C, Liu P, Liu Z, Liu Q, et al. A new eudesmane sesquiterpene glucoside from Liriope muscari fibrous roots. Molecules. 2011;16:9017-24 pubmed publisher
    ..39 ?g/mL) also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC(50) value of 182.56 ?g/mL...
  17. Hur J, Lee P, Kim J, Kim A, Kim H, Kim S. Induction of nerve growth factor by butanol fraction of Liriope platyphylla in C6 and primary astrocyte cells. Biol Pharm Bull. 2004;27:1257-60 pubmed
    ..GF109203X also decreased NGF expression in C6 cells. Taken together, our results suggest that astroglial NGF enhanced by BLP in a PKC-dependent pathway contributed to the induction of neurite outgrowth of PC12 cells...
  18. Jiang T, Huang B, Zhang Q, Han T, Zheng H, Qin L. [Studies on chemical constituents of Liriope platyphylla]. Zhong Yao Cai. 2007;30:1079-81 pubmed
    ..Compound I, II and V were isolated from this genus of Liriope for the first time. Compound III and IV were isolated from this plant for the first time...
  19. Mei L, Zhen Chang W, Hao Jie D, Li C, Qing Gang X, Jing L. Response surface optimization of polysaccharides extraction from Liriope roots and its modulatory effect on Sjogren syndrome. Int J Biol Macromol. 2009;45:284-8 pubmed publisher
    ..Therefore, the present results revealed that liriope polysaccharides exert a protective effect against tissue damage in rats with sjogren syndrome (SS)...
  20. Bai X, Chen X, Liu Y, Tian L, Zhou Q, Liu S, et al. Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice. J Ethnopharmacol. 2009;125:482-6 pubmed publisher
    ..prolifer on the InsR/IRS-1/PI3K pathway and glucose metabolism in type 2 diabetic mice...
  21. Li W, Cheng X, Liu J, Lin R, Wang G, Du S, et al. Phenolic compounds and antioxidant activities of Liriope muscari. Molecules. 2012;17:1797-808 pubmed publisher
    ..Their in vitro antioxidant activities were assessed by the DPPH and ABTS scavenging methods with microplate assays. The structure-activity relationships of compounds 1-3 are discussed...
  22. Kim H, Park S, Kim D, Park S, Lee H, Hwang D, et al. Effects of the roots of Liriope Platyphylla Wang Et tang on gastrointestinal motility function. J Ethnopharmacol. 2016;184:144-53 pubmed publisher
    ..Therefore, this study shows that LPE offers a basis for the development of a prokinetic agent that prevents or alleviates GI motility dysfunctions. ..
  23. Wu Y, Zhang L, Huang Q, Xiang Z, Guo Q. [Residuals of organochlorine pesticides and heavy metals in soil and water of planting base and Liriope muscari]. Zhongguo Zhong Yao Za Zhi. 2009;34:1351-4 pubmed
    ..To analyze the residuals of organochlorine pesticides and heavy metals in soil, water and Radix Liriopes from planting bases in Quanzhou city, and evaluate the quality of the herb...
  24. Hu Z, Chen L, Qi J, Wang Y, Zhang H, Yu B. Two new benzofuran derivatives with anti-inflammatory activity from Liriope spicata var. prolifera. Fitoterapia. 2011;82:190-2 pubmed publisher
    ..Compounds 1 and 2 exhibited significant inhibitory activity against neutrophil respiratory burst stimulated by phorbol 12-myristate 13-acetate (PMA) with IC(50) value of 4.15 ± 0.07 and 5.96 ± 0.37 ?M, respectively...
  25. Hu Z, Jiang C, Qin M, Qi J, Yu B. [Determination of 25(R, S) ruscogenin 1-O-[beta-D-glucopyranosyl (1 --> 2)] [beta-D-xylopyranosyl (1 --> 3)] beta-D-fucopyranoside in Liriope muscari from different habitats and different harvest time by HPLC-ELSD]. Zhongguo Zhong Yao Za Zhi. 2010;35:2508-10 pubmed
  26. Wang K, Ju X, Zhang L, Wang W, Shen L. [A novel C27-steroidal glycoside sulfate from Liriope graminifolia]. Yao Xue Xue Bao. 2012;47:619-23 pubmed
    ..Compound 1 has cytotoxic activities against K562 and HL60 cells with IC50 values of 18.6 microg x mL(-1) and 16.5 microg x mL(-1), respectively...
  27. Zhou Q, Zhou J, Wang J, Lu W, Wang X, Chen J. [Comparative study on meiotic behavior and pollen development of medicinal plants Liriope spicata var. prolifera and L. spicata]. Zhongguo Zhong Yao Za Zhi. 2009;34:1199-203 pubmed
    ..To reveal the mechanism of sterility of Liriope spicata var. prolifera...
  28. Kwak M, Kim J, Hwang I, Lee Y, An B, Hong J, et al. Quantitative evaluation of therapeutic effect of Liriope platyphylla on phthalic anhydride-induced atopic dermatitis in IL-4/Luc/CNS-1 Tg mice. J Ethnopharmacol. 2013;148:880-9 pubmed publisher
    ..A variety of previous pharmacological studies have suggested that Liriope platyphylla may exert beneficial biological effects on inflammation, diabetes, neurodegenerative disorder, obesity, and atopic dermatitis (AD)...
  29. Tian Y, Ma S, Lin B, Kou J, Yu B. Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari. Indian J Pharmacol. 2013;45:283-5 pubmed publisher
    ..To investigate the anti-thrombotic activity of DT-13 in experimental animal models...
  30. Wan X, Huang Y, Lai Z, Chen J. [Callus induction of Liriope muscari and its dynamic accumulation of polysaccharide]. Zhong Yao Cai. 2012;35:171-5 pubmed
    ..To study the induction rate of callus tissue in four different explants of stem, root, leaf and fruit of Liriope muscari...
  31. Mao C, Xie H, Chen S, Valverde B, Qiang S. Multiple mechanism confers natural tolerance of three lilyturf species to glyphosate. Planta. 2016;243:321-35 pubmed publisher
    ..Therefore, a combination of unique EPSPS structure and increased gene copy number and expression contribute to natural glyphosate tolerance in the three lilyturf species. ..
  32. Li G, Park Y. SCAR markers for discriminating species of two genera of medicinal plants, Liriope and Ophiopogon. Genet Mol Res. 2012;11:2987-96 pubmed
    ..This is the first report of a species-specific SCAR marker for this group. These markers will be useful for rapid identification of closely related Liriope and Ophiopogon species...
  33. Jiang T, Tang X, Wu J, Wang L, Huang M, Han T, et al. [Study on chemical constituents of the root of Liriope platyphylla]. Zhong Yao Cai. 2011;34:1537-9 pubmed
    ..To study the constituents from the root of Liriope platypgylla...
  34. Zhao R, Sun L, Lin S, Bai X, Yu B, Yuan S, et al. The saponin monomer of dwarf lilyturf tuber, DT-13, inhibits angiogenesis under hypoxia and normoxia via multi-targeting activity. Oncol Rep. 2013;29:1379-86 pubmed publisher
    ..Our data suggest that DT-13 inhibits angiogenesis under normoxia and hypoxia and also inhibits angiogenesis induced by vascular endothelial growth factor via targeting at multi elements...
  35. Cheng Z, Wu T, Bligh S, Bashall A, Yu B. cis-Eudesmane sesquiterpene glycosides from Liriope muscari and Ophiopogon japonicus. J Nat Prod. 2004;67:1761-3 pubmed
    ..The structure and the relative configuration of compound 1 were confirmed by X-ray crystallographic analysis. This is the first time that cis-eudesmane-type sesquiterpenes have been reported from the genera Ophiopogon and Liriope...