galanthus

Summary

Summary: A plant genus in the family Amaryllidaceae. Galanthus nivalis L. is the source of GALANTHAMINE.

Top Publications

  1. Poulsen M, Kroghsbo S, Schrøder M, Wilcks A, Jacobsen H, Miller A, et al. A 90-day safety study in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA). Food Chem Toxicol. 2007;45:350-63 pubmed
    ..The present 90-day feeding study was designed to assess the safety of a rice variety expressing the snowdrop Galanthus nivalis lectin (GNA lectin), and forms part of a EU-funded project where the objective has been to develop and ..
  2. Balzarini J, Schols D, Neyts J, Van Damme E, Peumans W, De Clercq E. Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro. Antimicrob Agents Chemother. 1991;35:410-6 pubmed
    The alpha-(1-3)-D-mannose- and alpha-(1-6)-D-mannose-specific agglutinins (lectins) from Galanthus nivalis, Hippeastrum hybrid, Narcissus pseudonarcissus, and Listera ovata inhibited infection of MT-4 cells by human immunodeficiency ..
  3. Shibuya N, Goldstein I, Van Damme E, Peumans W. Binding properties of a mannose-specific lectin from the snowdrop (Galanthus nivalis) bulb. J Biol Chem. 1988;263:728-34 pubmed
    ..Glycopeptides which carry Man(alpha 1-3)Man units were retarded on the immobilized GNA column whereas those lacking this unit or with hybrid type glycan chains were not retarded on the column...
  4. Raemaekers R, de Muro L, Gatehouse J, Fordham Skelton A. Functional phytohemagglutinin (PHA) and Galanthus nivalis agglutinin (GNA) expressed in Pichia pastoris correct N-terminal processing and secretion of heterologous proteins expressed using the PHA-E signal peptide. Eur J Biochem. 1999;265:394-403 pubmed
    Phytohemagglutinin (Phaseolus vulgaris agglutinin; PHA; E- and L-forms) and snowdrop lectin (Galanthus nivalis agglutinin; GNA) were expressed in Pichia pastoris using native signal peptides, or the Saccharomyces alpha-factor ..
  5. Baumgartner P, Harper K, Raemaekers R, Durieux A, Gatehouse A, Davies H, et al. Large-scale production and purification of recombinant Galanthus nivalis agglutinin (GNA) expressed in the methylotrophic yeast Pichia pastoris. Biotechnol Lett. 2003;25:1281-5 pubmed
    The gene coding for agglutinin from Galanthus nivalis (GNA) was expressed in, and secreted by, the methylotrophic yeast, Pichia pastoris. Transformants of P...
  6. Berkov S, Sidjimova B, Evstatieva L, Popov S. Intraspecific variability in the alkaloid metabolism of Galanthus elwesii. Phytochemistry. 2004;65:579-86 pubmed
    Alkaloid pattern of individuals from 16 Bulgarian Galanthus elwesii populations was investigated by GC/MS and TLC. Twenty-one Amaryllidaceae alkaloids were detected and 14 of them were identified...
  7. Berkov S, Reyes Chilpa R, Codina C, Viladomat F, Bastida J. Revised NMR data for incartine: an alkaloid from Galanthus elwesii. Molecules. 2007;12:1430-5 pubmed
    Phytochemical studies on Galanthus elwesii resulted in the isolation of five alkaloids: incartine, hordenine, hippeastrine, 8-O-demethylhomolycorine and lycorine...
  8. Hsieh L, Lin C, Su B, Jan T, Chen C, Wang C, et al. Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus. Antiviral Res. 2010;88:25-30 pubmed publisher
    ..The results showed that Galanthus nivalis agglutinin (GNA) and nelfinavir effectively inhibited FCoV replication...
  9. Fouquaert E, Peumans W, Gheysen G, Van Damme E. Identical homologs of the Galanthus nivalis agglutinin in Zea mays and Fusarium verticillioides. Plant Physiol Biochem. 2011;49:46-54 pubmed publisher
    The structural domain corresponding to the Galanthus nivalis agglutinin (GNA) is a mannose-binding motif that was originally discovered in plants but according to recent data also occurs in other eukaryotes and prokaryotes...

More Information

Publications114 found, 100 shown here

  1. Berkov S, Bastida J, Sidjimova B, Viladomat F, Codina C. Alkaloid diversity in Galanthus elwesii and Galanthus nivalis. Chem Biodivers. 2011;8:115-30 pubmed publisher
    ..lycorine, homolycorine, tazettine, haemanthamine, narciclasine, and tyramine types were detected by GC/MS in 25 Galanthus elwesii and seven Galanthus nivalis populations, collected from different locations in Bulgaria...
  2. Wu L, Bao J. Anti-tumor and anti-viral activities of Galanthus nivalis agglutinin (GNA)-related lectins. Glycoconj J. 2013;30:269-79 pubmed publisher
    b>Galanthus nivalis agglutinin (GNA)-related lectin family, a superfamily of strictly mannose-binding specific lectins widespread among monocotyledonous plants, is well-known to possess a broad range of biological functions such as anti-..
  3. Van Damme E, Kaku H, Perini F, Goldstein I, Peeters B, Yagi F, et al. Biosynthesis, primary structure and molecular cloning of snowdrop (Galanthus nivalis L.) lectin. Eur J Biochem. 1991;202:23-30 pubmed
    Poly(A)-rich RNA isolated from ripening ovaries of snowdrop (Galanthus nivalis L.) yielded a single 17-kDa lectin polypeptide upon translation in a wheat-germ cell-free system. This lectin was purified by affinity chromatography...
  4. Hester G, Kaku H, Goldstein I, Wright C. Structure of mannose-specific snowdrop (Galanthus nivalis) lectin is representative of a new plant lectin family. Nat Struct Biol. 1995;2:472-9 pubmed
    Tetrameric Galanthus nivalis agglutinin (50,000 M(r)) belongs to a super-family of alpha-D-mannose-specific plant bulb lectins known to be potent inhibitors of retroviruses. The 2...
  5. Hester G, Wright C. The mannose-specific bulb lectin from Galanthus nivalis (snowdrop) binds mono- and dimannosides at distinct sites. Structure analysis of refined complexes at 2.3 A and 3.0 A resolution. J Mol Biol. 1996;262:516-31 pubmed
    b>Galanthus nivalis agglutinin (GNA, a 50 kDa tetramer) is a mannose-specific lectin of the Amaryllidaceae family of bulb lectins...
  6. Naughton P, Grant G, Bardocz S, Pusztai A. Modulation of Salmonella infection by the lectins of Canavalia ensiformis (Con A) and Galanthus nivalis (GNA) in a rat model in vivo. J Appl Microbiol. 2000;88:720-7 pubmed
    The plant lectins, Concanavalin A (Con A) and Galanthus nivalis agglutinin (GNA) have been prefed to rats for 3 d pre- and 6 d postinfection with Salmonella typhimurium S986 or Salm. enteritidis 857...
  7. Balzarini J, Hatse S, Vermeire K, Princen K, Aquaro S, Perno C, et al. Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection. Antimicrob Agents Chemother. 2004;48:3858-70 pubmed
    The plant lectins derived from Galanthus nivalis (Snowdrop) (GNA) and Hippeastrum hybrid (Amaryllis) (HHA) selectively inhibited a wide variety of human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains and clinical (CXCR4- and ..
  8. Balzarini J, Van Laethem K, Hatse S, Froeyen M, Van Damme E, Bolmstedt A, et al. Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis. Mol Pharmacol. 2005;67:1556-65 pubmed
    The plant lectins from Hippeastrum hybrid (HHA) and Galanthus nivalis (GNA) are 50,000-D tetramers showing specificity for alpha-(1,3) and/or alpha-(1,6)-mannose oligomers...
  9. Berkov S, Codina C, Viladomat F, Bastida J. Alkaloids from Galanthus nivalis. Phytochemistry. 2007;68:1791-8 pubmed
    Phytochemical studies on Galanthus nivalis of Bulgarian origin resulted in the isolation of five compounds: 11-O-(3'-hydroxybutanoyl)hamayne, 3,11-O-(3',3''-dihydroxybutanoyl)hamayne, 3-O-(2''-butenoyl)-11-O-(3'-hydroxybutanoyl)hamayne, ..
  10. Fouquaert E, Hanton S, Brandizzi F, Peumans W, Van Damme E. Localization and topogenesis studies of cytoplasmic and vacuolar homologs of the Galanthus nivalis agglutinin. Plant Cell Physiol. 2007;48:1010-21 pubmed
    The Galanthus nivalis agglutinin (GNA) is synthesized as a preproprotein...
  11. Fouquaert E, Smith D, Peumans W, Proost P, Balzarini J, Savvides S, et al. Related lectins from snowdrop and maize differ in their carbohydrate-binding specificity. Biochem Biophys Res Commun. 2009;380:260-5 pubmed publisher
    Searches in an EST database from maize revealed the expression of a protein related to the Galanthus nivalis (GNA) agglutinin, referred to as GNA(maize)...
  12. Bharathi Y, Vijaya Kumar S, Pasalu I, Balachandran S, Reddy V, Rao K. Pyramided rice lines harbouring Allium sativum (asal) and Galanthus nivalis (gna) lectin genes impart enhanced resistance against major sap-sucking pests. J Biotechnol. 2011;152:63-71 pubmed publisher
    ..through sexual crosses made between two stable transgenic rice lines containing Allium sativum (asal) and Galanthus nivalis (gna) lectin genes...
  13. Hoorelbeke B, Van Damme E, Rouge P, Schols D, Van Laethem K, Fouquaert E, et al. Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea mays strongly determine their eventual anti-HIV activity. Retrovirology. 2011;8:10 pubmed publisher
    In a recent report, the carbohydrate-binding specificities of the plant lectins Galanthus nivalis (GNA) and the closely related lectin from Zea mays (GNAmaize) were determined by glycan array analysis and indicated that GNAmaize ..
  14. Fukushima K, Yamashita K. Interleukin-2 carbohydrate recognition modulates CTLL-2 cell proliferation. J Biol Chem. 2001;276:7351-6 pubmed
    ..Among the components of this complex, only the IL-2 receptor alpha subunit was stained with Galanthus nivalis agglutinin which specifically recognizes high-mannose type glycans...
  15. Heinrich M, Lee Teoh H. Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol. 2004;92:147-62 pubmed
    ..Narcissus species, Galanthus spp...
  16. Hammar L, Hirsch I, Machado A, de Mareuil J, Baillon J, Bolmont C, et al. Lectin-mediated effects on HIV type 1 infection in vitro. AIDS Res Hum Retroviruses. 1995;11:87-95 pubmed
    ..In this study we show that one such agent, the Galanthus nivalis lectin (GNA), also blocks infection at the target cell level...
  17. da Silva R, Gordon S. Phagocytosis stimulates alternative glycosylation of macrosialin (mouse CD68), a macrophage-specific endosomal protein. Biochem J. 1999;338 ( Pt 3):687-94 pubmed
    ..The phagocytic glycoform displays increased binding of agglutinins from peanut, Amaranthus caudatus and Galanthus nivalis, whereas binding of the sialic-acid-specific Maakia amurensis agglutinin is slightly reduced...
  18. Gomez Santos L, Alonso E, Diaz Flores L, Madrid J, Sáez F. Transdifferentiation of mucous neck cells into chief cells in fundic gastric glands shown by GNA lectin histochemistry. Tissue Cell. 2017;49:746-750 pubmed publisher
    ..The aim of our work was to analyze the expression of Mannose (Man) in the rat gastric glands by means of Galanthus nivalis lectin (GNA) histochemistry to identify the differences between MNC, pre-ZCs and ZCs and to establish ..
  19. Wallis G, Hemming F, Peberdy J. Secretion of two beta-fructofuranosidases by Aspergillus niger growing in sucrose. Arch Biochem Biophys. 1997;345:214-22 pubmed
    ..however, SUC 1 had approximately 10-fold more mannose and this was utilized to separate it from SUC 2 by Galanthus nivalis lectin affinity...
  20. Fahlbusch B, Rudeschko O, Schumann C, Steurich F, Henzgen M, Schlenvoigt G, et al. Further characterization of IgE-binding antigens in kiwi, with particular emphasis on glycoprotein allergens. J Investig Allergol Clin Immunol. 1998;8:325-32 pubmed
    ..In contrast, strong binding of Galanthus nivalis agglutinin (indicating mannose residues) and concanavalin A was found on birch pollen blots...
  21. Hägerbäumer P, Vieth M, Anders M, Schumacher U. Lectin Histochemistry Shows WGA, PHA-L and HPA Binding Increases During Progression of Human Colorectal Cancer. Anticancer Res. 2015;35:5333-9 pubmed
    ..HPA), Phaseolus vulgaris (PHA-L), Ulex europaeus (UEA-I), Sambucus nigra (SNA-I), Canavalia ensiformis (Con A), Galanthus nivalis (GNA) and Dolichos biflorus (DBA)...
  22. Kilgore M, Holland C, Jez J, Kutchan T. Identification of a Noroxomaritidine Reductase with Amaryllidaceae Alkaloid Biosynthesis Related Activities. J Biol Chem. 2016;291:16740-52 pubmed publisher
    ..and Galanthus spp...
  23. Savage S, Donaldson L, Sopori M. T cell-B cell interaction: autoreactive T cells recognize B cells through a terminal mannose-containing superantigen-like glycoprotein. Cell Immunol. 1993;146:11-27 pubmed
    ..Furthermore, pretreatment of B cells with GNA (a lectin from Galanthus nivalis that reacts with free terminal-mannose residues on glycoconjugates) also inhibits their ability to ..
  24. Barre A, Van Damme E, Peumans W, Rouge P. Homology modelling of the core domain of the endogenous lectin comitin: structural basis for its mannose-binding specificity. Plant Mol Biol. 1999;39:969-78 pubmed
    ..discoideum has been modelled from the X-ray coordinates of the monocot mannose-binding lectin from snowdrop (Galanthus nivalis)...
  25. Mi X, Liu X, Yan H, Liang L, Zhou X, Yang J, et al. Expression of the Galanthus nivalis agglutinin (GNA) gene in transgenic potato plants confers resistance to aphids. C R Biol. 2017;340:7-12 pubmed publisher
    ..In this study, transgenic potato plants expressing Galanthus nivalis agglutinin (GNA) gene were developed using CaMV 35S and ST-LS1 promoters generating six transgenic lines ..
  26. Petersen A, Becker W, Moll H, Blümke M, Schlaak M. Studies on the carbohydrate moieties of the timothy grass pollen allergen Phl p I. Electrophoresis. 1995;16:869-75 pubmed
    ..to Phl p I components: Aleuria aurantia agglutinin showed strong reactivity (indicating fucose residues), while Galanthus nivalis agglutinin (indicating mannose residues) and concanavalin A (indicating mannose, glucose or N-..
  27. Wright C, Hester G. The 2.0 A structure of a cross-linked complex between snowdrop lectin and a branched mannopentaose: evidence for two unique binding modes. Structure. 1996;4:1339-52 pubmed
    b>Galanthus nivalis agglutinin (GNA), a mannose-specific lectin from snowdrop bulbs, is a tetrameric member of the family of Amaryllidaceae lectins that exhibit antiviral activity towards HIV...
  28. Focarelli R, Leotta F, Lampariello R, Rosati F. Vitelline coat of Unio elongatulus: III. Glycan chain analysis of the 220- and 180-kD components by means of lectins. Mol Reprod Dev. 1995;40:205-10 pubmed
    ..The lectin from Galanthus nivalis, which recognizes terminal mannose residues of N-linked high mannose type oligosaccharide chains, bound ..
  29. Gilljam G. Envelope glycoproteins of HIV-1, HIV-2, and SIV purified with Galanthus nivalis agglutinin induce strong immune responses. AIDS Res Hum Retroviruses. 1993;9:431-8 pubmed
    ..The glycoproteins were purified by a one-step procedure to a high level of purity by using Galanthus nivalis agglutinin (GNA). The purified glycoprotein had CD4-binding and antigenic reactivities...
  30. Mroczek T. Highly efficient, selective and sensitive molecular screening of acetylcholinesterase inhibitors of natural origin by solid-phase extraction-liquid chromatography/electrospray ionisation-octopole-orthogonal acceleration time-of-flight-mass spectromet. J Chromatogr A. 2009;1216:2519-28 pubmed publisher
    ..In this way, more potent than galanthamine AChE inhibitor namely 1,2-dihydrogalanthamine in Narcissus jonquilla 'Pipit' extract could be found (with IC(50) value 0.19 microM lower of about 42% than that of galanthamine)...
  31. Kasper M, Sakai K, Koslowski R, Wenzel K, Haroske G, Schuh D, et al. Localization of surfactant protein A (SP-A) in alveolar macrophage subpopulations of normal and fibrotic rat lung. Histochemistry. 1994;102:345-52 pubmed
    ..biflorus lectin (DBA), soybean agglutinin (SBA)] and of the mannose group [Canavalia ensiformis lectin (ConA), Galanthus nivalis lectin (GNA)] was studied in normal and fibrotic rat lung tissues...
  32. Pereira P, Meagher J, Winter H, Goldstein I, Paschoalin V, Silva J, et al. High-resolution crystal structures of Colocasia esculenta tarin lectin. Glycobiology. 2017;27:50-56 pubmed publisher
    ..91 Å, respectively. Each tarin monomer forms a canonical β-prism II fold, common to all members of Galanthus nivalis agglutinin (GNA) family, which is partially stabilized by a disulfide bond and a conserved hydrophobic ..
  33. Burger A, Kaur G, Hollingshead M, Fischer R, Nagashima K, Malspeis L, et al. Antiproliferative activity in vitro and in vivo of the spicamycin analogue KRN5500 with altered glycoprotein expression in vitro. Clin Cancer Res. 1997;3:455-63 pubmed
    ..Western blotting after prolonged (40-48 h) incubation with lectins that target mannose-containing carbohydrates, Galanthus nivalis agglutinin and concanavalin A, a qualitative change in the pattern of mannose-containing glycoproteins ..
  34. Heffer Lauc M, Latin V, Breyer B, Flogel M, Muller W, Lauc G. Glycoprotein and ganglioside changes in human trophoblasts after exposure to pulsed Doppler ultrasound. Ultrasound Med Biol. 1995;21:579-84 pubmed
    ..Glycoproteins were detected using alpha-D-mannose specific lectins from Galanthus nivalis and Narcissus pseudonarcissus...
  35. Kreimer G, Brohsonn U, Melkonian M. Isolation and partial characterization of the photoreceptive organelle for phototaxis of a flagellate green alga. Eur J Cell Biol. 1991;55:318-27 pubmed
    ..The presence of glycoproteins in fraction 2a was demonstrated by binding of the mannose-specific lectin Galanthus nivalis agglutinin to several high molecular weight polypeptides...
  36. Pusztai A, Grant G, Spencer R, Duguid T, Brown D, Ewen S, et al. Kidney bean lectin-induced Escherichia coli overgrowth in the small intestine is blocked by GNA, a mannose-specific lectin. J Appl Bacteriol. 1993;75:360-8 pubmed
    ..common carbohydrate specificity, the inclusion in the diet of the mannose-specific agglutinin from snowdrop (Galanthus nivalis) bulbs (GNA) significantly reduced the extent of E...
  37. Letaïef S, Landemore G, Oulhaj N, Izard J. Characterization of the non-sulphated highly anionic Kurloff cell glycoconjugates by lectin- and immunoblotting: evidence for the presence of alpha (2,8)-linked polysialic acid-bearing molecules. Biol Cell. 1993;77:269-76 pubmed
    ..A large amount of these glycoproteins is not of the high-mannose type since Galanthus nivalis agglutinin reacted weakly with peak IV...
  38. Russo P, Frustaci A, Del Bufalo A, Fini M, Cesario A. Multitarget drugs of plants origin acting on Alzheimer's disease. Curr Med Chem. 2013;20:1686-93 pubmed
    ..This review is limited to plant chemicals having different targets with actual (galantamine) or promising (drugs from Crocus sativus, Ginkgo biloba, Salvia species, and Huperzia serrata) clinical evidence in people with dementia or AD. ..
  39. Maslanka M, Panis B, Bach A. Cryopreservation of Galanthus elwesii Hook. apical meristems by droplet vitrification. Cryo Letters. 2013;34:1-9 pubmed
    The aim of this study was to develop an efficient cryopreservation protocol for the geophyte giant snowdrop (Galanthus elwesii Hook.) that guarantees a high rate of survival and plant regeneration after cryopreservation...
  40. Sahoo A, Dandapat J, Dash U, Kanhar S. Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease. J Ethnopharmacol. 2018;215:42-73 pubmed publisher
    ..Most of drugs are synthetic or natural products as galanthamine is an alkaloid obtained from Galanthus spp. Huperzine A, an alkaloid found in Huperzia spp...
  41. Van Leuven F, Torrekens S, Van Damme E, Peumans W, Van den Berghe H. Mannose-specific lectins bind alpha-2-macroglobulin and an unknown protein from human plasma. Protein Sci. 1993;2:255-63 pubmed
    GNA, the mannose-specific lectin from Galanthus nivalis was confirmed to bind alpha-2-macroglobulin (A2M) but another protein was copurified with A2M from total human plasma...
  42. Tsakadze D, Samsoniya S, Ziaev R, Abdusamatov A. Alkaloid and phenolic compounds of Galanthus caucasicus, Magnolia obovata, Cocculus laurifolius, and Veratrum lobelianum grown in Georgia. Mol Divers. 2005;9:41-4 pubmed
    A collection of plants from the country of Georgia (Galanthus caucasicus, Magnolia obovata, Cocculus laurifolius, and Veratrum lobelianum) has been studied for their alkaloid content...
  43. van der Meer F, de Haan C, Schuurman N, Haijema B, Peumans W, Van Damme E, et al. Antiviral activity of carbohydrate-binding agents against Nidovirales in cell culture. Antiviral Res. 2007;76:21-9 pubmed
    ..In this article the application of the plant lectins Hippeastrum hybrid agglutinin (HHA), Galanthus nivalis agglutinin (GNA), Cymbidium sp...
  44. Berkov S, Cuadrado M, Osorio E, Viladomat F, Codina C, Bastida J. Three new alkaloids from Galanthus nivalis and Galanthus elwesii. Planta Med. 2009;75:1351-5 pubmed publisher
    Phytochemical studies on Galanthus species resulted in the isolation of three new compounds: 3,3'-O-(3',3''-dihydroxybutanoyl)hamayne and 11,3'-O-(3',3''-dihydroxybutanoyl)hamayne from G...
  45. Benallal M, Anner B. Major organ-specific glycoproteins in isolated brain and kidney membranes identified as Na,K-ATPase subunits by combined glycan-, lectin-, and immunoblotting. Biosci Rep. 1995;15:21-36 pubmed
    ..Further, Datura stramonium and Galanthus nivalis agglutinins recognize the Na,K-ATPase subunits in a mutually exclusive manner in membranes from human, ..
  46. Amin K, Beillevaire D, Mahmoud E, Hammar L, Mardh P, Froman G. Binding of Galanthus nivalis lectin to Chlamydia trachomatis and inhibition of in vitro infection. APMIS. 1995;103:714-20 pubmed
    ..present in Chlamydia trachomatis, serotype L1, elementary bodies (EBs) was earlier found to bind the lectin from Galanthus nivalis (GNA)...
  47. Barisic K, Lauc G, Dumic J, Pavlovic M, Flogel M. Changes of glycoprotein patterns in sera of humans under stress. Eur J Clin Chem Clin Biochem. 1996;34:97-101 pubmed
    ..Using SDS-electrophoresis, blotting and digoxigenin-labelled lectins (Sambucus nigra agglutinin, Galanthus nivalis agglutinin, Datura stramonium agglutinin, Maackia amurensis agglutinin and peanut (Arachis hypogaea) ..
  48. Litynska A, Przybyło M. Age-related profile of beta-N-acetylhexosaminidase glycosylation in rat liver. Acta Biochim Pol. 1998;45:791-7 pubmed
    ..were present in all the groups except for 1-week-old rats in which only a positive reaction with lectins from Galanthus nivalis and Aleuria aurantia was observed...
  49. Bacon D, Johnson W, Rodgers F. Identification and characterisation of a cytotoxic porin-lipopolysaccharide complex from Campylobacter jejuni. J Med Microbiol. 1999;48:139-48 pubmed
    ..lysate test, indicating that the co-purifying carbohydrate was LPS, and had specificity for the lectins Galanthus nivalis agglutinin, Maackia amurensis agglutinin and Datura stramonium agglutinin...
  50. Valentin J, Bruijn J, Paul L. Donor treatment with mycophenolate mofetil: protection against ischemia-reperfusion injury in the rat. Transplantation. 2000;69:344-50 pubmed
    ..was examined after stimulation with interleukin 1 in the presence or absence of mycophenolic acid using labeled Galanthus nivalis agglutinin...
  51. Chervenak M, Toone E. Calorimetric analysis of the binding of lectins with overlapping carbohydrate-binding ligand specificities. Biochemistry. 1995;34:5685-95 pubmed
    ..system of lectins consists of concanavalin A, the lectin isolated from Dioclea grandiflora, and the lectin from Galanthus nivalis...
  52. Bishop P, Boulton M, McLeod D, Stoddart R. Glycan localization within the human interphotoreceptor matrix and photoreceptor inner and outer segments. Glycobiology. 1993;3:403-12 pubmed
    ..In addition, both the rod and cone outer segments bound strongly Galanthus nivalis agglutinin (which binds terminal Man alpha 1, 3Man-) and the rod outer segments bound selectively the ..
  53. Bertalanffy P, Dubsky P, Wolner E, Weigel G. Alterations of endothelial nucleotide levels by mycophenolic acid result in changes of membrane glycosylation and E-selectin expression. Clin Chem Lab Med. 1999;37:259-64 pubmed
    ..The staining of the endothelial cell membranes with lectins specific for fucose and mannose (Ulex europaeus- and Galanthus nivalis agglutinin, respectively) was reduced, reflecting an inhibition of fucose and mannose incorporation into ..
  54. Turville S, Vermeire K, Balzarini J, Schols D. Sugar-binding proteins potently inhibit dendritic cell human immunodeficiency virus type 1 (HIV-1) infection and dendritic-cell-directed HIV-1 transfer. J Virol. 2005;79:13519-27 pubmed
    ..potential microbicidal compounds, including cyanovirin (CNV); the plant lectins Hippeastrum hybrid agglutinin, Galanthus nivalis agglutinin, Urtica dioica agglutinin, and Cymbidium hybrid agglutinin; and the glycan mannan...
  55. Unver N, Kaya G, Werner C, Verpoorte R, Gözler B. Galanthindole: a new indole alkaloid from Galanthus plicatus ssp. byzantinus. Planta Med. 2003;69:869-71 pubmed
    A new indole alkaloid, galanthindole, was isolated from Galanthus plicatus ssp. byzantinus (Amaryllidaceae), a plant native to northwestern Turkey...
  56. Bakış Y, Otu H, Taşçı N, Meydan C, Bilgin N, Yüzbaşıoğlu S, et al. Testing robustness of relative complexity measure method constructing robust phylogenetic trees for Galanthus L. using the relative complexity measure. BMC Bioinformatics. 2013;14:20 pubmed publisher
    ..present an application of the RCM method to reconstruct robust phylogenetic trees using sequence data for genus Galanthus obtained from different regions in Turkey...
  57. Sarikaya B, Berkov S, Bastida J, Kaya G, Onur M, Somer N. GC-MS investigation of Amaryllidaceae alkaloids in Galanthus xvalentinei nothosubsp. subplicatus. Nat Prod Commun. 2013;8:327-8 pubmed
    A GC-MS analysis of alkaloids in the aerial parts and bulbs of Galanthus xvalentinei nothosubsp. subplicatus was performed for the first time...
  58. Morgan G, Kail M, Hollinshead M, Vaux D. Combined biochemical and cytological analysis of membrane trafficking using lectins. Anal Biochem. 2013;441:21-31 pubmed publisher
    ..pre-Golgi intermediates are found to contain a subset of N-linked ?-mannose glycans that bind the lectins Galanthus nivalis agglutinin (GNA), Pisum sativum agglutinin (PSA), and Lens culinaris agglutinin (LCA) but not lectins ..
  59. Resetár A, Demeter Z, Ficsor E, Balazs A, Mosolygó A, Szoke E, et al. Growth regulator requirement for in vitro embryogenic cultures of snowdrop (Galanthus nivalis L.) suitable for germplasm preservation. Acta Biol Hung. 2014;65:165-77 pubmed publisher
    ..scale-derived tissue cultures capable of efficient shoot and plant regeneration in three genotypes of snowdrop (Galanthus nivalis L., Amaryllidaceae), a protected ornamental plant...
  60. Brunden K. Age-dependent changes in the oligosaccharide structure of the major myelin glycoprotein, P0. J Neurochem. 1992;58:1659-66 pubmed
    ..adult nerve during concanavalin A chromatography and (b) the inability of P0 from adult nerve to interact with Galanthus nivalis agglutinin...
  61. Jones C, Morrison C, Stoddart R. Histochemical analysis of rat testicular glycoconjugates. 1. Subsets of N-linked saccharides in seminiferous tubules. Histochem J. 1992;24:319-26 pubmed
    The distribution of N-linked glycans in rat testis has been probed using a panel of lectins derived from Galanthus nivalis (snowdrop, GNA), Canavalia ensiformis (jack bean, Con A), Lens culinaris (lentil, LCA), Pisum sativum (garden pea, ..
  62. Rao K, Rathore K, Hodges T, Fu X, Stoger E, Sudhakar D, et al. Expression of snowdrop lectin (GNA) in transgenic rice plants confers resistance to rice brown planthopper. Plant J. 1998;15:469-77 pubmed
    Snowdrop lectin (Galanthus nivalis agglutinin; GNA) has been shown previously to be toxic towards rice brown planthopper (Nilaparvata lugens; BPH) when administered in artificial diet...
  63. Garcia de Yebenes J. [Zoofilia as late complication of Parkinson's disease. Circe drugs and Mercury antidotes]. Neurologia. 2003;18:351 pubmed
  64. Rousseau C, Felin M, Doyennette Moyne M, Seve A. CBP70, a glycosylated nuclear lectin. J Cell Biochem. 1997;66:370-85 pubmed
    ..chromatography on immobilized lectins [Ricinus communis-l agglutinin (RCA-I), Arachis hypogaea agglutinin (PNA), Galanthus nivalis agglutinin (GNA), and wheat germ agglutinin (WGA)] and by lectin-blotting analysis Sambucus nigra ..
  65. Wood S, Wright L, Reynolds C, Rizkallah P, Allen A, Peumans W, et al. Structure of the native (unligated) mannose-specific bulb lectin from Scilla campanulata (bluebell) at 1.7 A resolution. Acta Crystallogr D Biol Crystallogr. 1999;55:1264-72 pubmed
    ..The fold of the polypeptide backbone closely resembles that found in the lectins from Galanthus nivalis (snowdrop) and Hippeastrum (amaryllis) and contains a threefold symmetric beta-prism made up of three ..
  66. Siridewa K, Froman G, Hammar L, Mardh P. Characterization of glycoproteins from Chlamydia trachomatis using lectins. APMIS. 1993;101:851-7 pubmed
    ..Terminal mannosidic structures were demonstrated in a 72 kDa glycopeptide (gp72) by its selective binding of Galanthus nivalis lectin (GNA)...
  67. Madan T, Banerjee B, Bhatnagar P, Shah A, Sarma P. Identification of 45 kD antigen in immune complexes of patients of allergic bronchopulmonary aspergillosis. Mol Cell Biochem. 1997;166:111-6 pubmed
    ..using various lectins (Maackia amurensis agglutinin, Sambucus nigra agglutinin, Peanut agglutinin, Galanthus nivalis agglutinin and Datura stramonium agglutinin) showed presence of both N-linked and O-linked sugar ..
  68. Kaya G, Gözler B. Quantitative and cytotoxic activity determinations on Galanthus nivalis subsp. cilicicus. Fitoterapia. 2005;76:340-3 pubmed
    Aerial and underground parts of Galanthus nivalis subsp. cilicicus, a wild-growing species in Turkey, were collected during two different vegetation periods in flowering and fruiting seasons...
  69. Devesly P, Cade C, Polokoff M, Botelho L. Evidence of glycosylated sites on the endothelin-1 receptor in Swiss 3T3 cells. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S134-6 pubmed
    ..1 h at 37 degrees C with concanavalin A, soybean agglutinin, Ulex europaeus agglutinin I, peanut agglutinin, or Galanthus nivalis agglutinin...
  70. Jones C, Koob B, Stoddart R, Hoffmann B, Leiser R. Lectin-histochemical analysis of glycans in ovine and bovine near-term placental binucleate cells. Cell Tissue Res. 1994;278:601-10 pubmed
    ..Several sub-types of N-glycan were present, with highly branched structures being abundant, as shown by Galanthus nivalis, Pisum sativum and Phaseolus vulgaris (leuko) agglutinins...
  71. Vandenbroeck K, Willems L, Billiau A, Opdenakker G, Huybrechts R. Glycoform heterogeneity of porcine interferon-gamma expressed in Sf9 cells. Lymphokine Cytokine Res. 1994;13:253-8 pubmed
    ..and the results of lectin blots, revealing strong affinity of the 19- and 21-kDa species for Galanthus nivalis agglutinin, support the presence of N-glycosidically linked high mannose-type chains in the carbohydrate ..
  72. Ooi L, Wang H, Ng T, Ooi V. Isolation and characterization of a mannose-binding lectin from leaves of the Chinese daffodil Narcissus tazetta. Biochem Cell Biol. 1998;76:601-8 pubmed
    ..lectin revealed considerable homology to lectins from the daffodil Narcissus pseudonarcissus, the snowdrop Galanthus nivalis (family Amaryllidaceae), the tulip Tulipa, and Kidachi aloe Aloe arborescens (family Liliaceae), and the ..
  73. Greenblatt H, Kryger G, Lewis T, Silman I, Sussman J. Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution. FEBS Lett. 1999;463:321-6 pubmed
    Galanthamine (GAL), an alkaloid from the flower, the common snowdrop (Galanthus nivalis), shows anticholinesterase activity...
  74. Wright L, Reynolds C, Rizkallah P, Allen A, Van Damme E, Donovan M, et al. Structural characterisation of the native fetuin-binding protein Scilla campanulata agglutinin: a novel two-domain lectin. FEBS Lett. 2000;468:19-22 pubmed
    ..Unlike most monocot mannose-binding lectins, such as Galanthus nivalis agglutinin from snowdrop bulbs, which fold into a single domain, SCAfet contains two domains with ..
  75. Roetzer T, Wittenzeller M, Haeckel H, Nekovar J. Phenology in central Europe--differences and trends of spring phenophases in urban and rural areas. Int J Biometeorol. 2000;44:60-6 pubmed
    ..the differences in the starting dates of the pre-spring phenophases, the beginning of flowering of the snowdrop (Galanthus nivalis) and forsythia (Forsythia sp...
  76. Conforti F, Loizzo M, Marrelli M, Menichini F, Statti G, Uzunov D, et al. Quantitative determination of Amaryllidaceae alkaloids from Galanthus reginae-olgae subsp. vernalis and in vitro activities relevant for neurodegenerative diseases. Pharm Biol. 2010;48:2-9 pubmed publisher
    ..work the qualitative and quantitative analysis of Amaryllidaceae-type alkaloids in the aerial parts and bulbs of Galanthus reginae-olgae Orph. subsp. vernalis Kamari is presented for the first time using GC-MS analysis...
  77. Weiler B, Schäcke H, Bachmann M, Brigido L, Gilbert M, Mills J, et al. Human immunodeficiency virus: novel enzyme-linked immunoassays for quantitation of envelope glycoprotein 120. J Virol Methods. 1991;32:287-301 pubmed
    ..specific interaction between gp120 and the mannose-specific lectins from Narcissus pseudonarcissus (NPL) and Galanthus nivalis (GNL)...
  78. Hinkula J, Gidlund M, Persson C, Osterhaus A, Wahren B. Enzyme immunoassay (ELISA) for the evaluation of antibodies directed to the CD4 receptor-binding site of the HIV gp120 molecule. J Immunol Methods. 1994;175:37-46 pubmed
    ..We have developed an ELISA, utilizing Galanthus nivalis agglutinin (GNA) which selectively binds native HIV envelope gp120 in culture medium...
  79. Crothers J, Chow D, Scalley M, Forte J. In vivo trafficking of nascent H(+)-K(+)-ATPase in rabbit parietal cells. Am J Physiol. 1995;269:G883-91 pubmed
    ..enriched in pre-beta, alpha-subunit was coprecipitated with pre-beta by a terminal mannose-specific lectin, Galanthus nivalis agglutinin, in the same ratio as the mature alpha:beta ratio...
  80. Wright L, Levy E, Patel N, Alhadeff J. Purification and characterization of cathepsin D from normal human breast tissue. J Protein Chem. 1997;16:171-81 pubmed
    ..3. Lectin blotting indicated that cathepsin D is a glycoprotein which is recognized by Galanthus nivalis agglutinin and concanavalin A, suggesting the presence of mannose residues...
  81. Bartoszewicz Z, Jaffe H, Sasaki M, Moller J, Stebbins J, Gebrekristos H, et al. Prominent 85-kDa oligomannosidic glycoproteins of rat brain are signal regulatory proteins and include the SHP substrate-1 for tyrosine phosphatases. J Neurochem. 1999;72:1688-93 pubmed
    The glycoprotein component in rat brain reacting most strongly with Galanthus nivalis agglutinin (GNA) on western blots migrates as an 85-kDa band...
  82. Bell H, Fitches E, Marris G, Bell J, Edwards J, Gatehouse J, et al. Transgenic GNA expressing potato plants augment the beneficial biocontrol of Lacanobia oleracea (Lepidoptera; Noctuidae) by the parasitoid Eulophus pennicornis (Hymenoptera; Eulophidae). Transgenic Res. 2001;10:35-42 pubmed
    The effect of expressing the gene encoding snowdrop lectin (Galanthus nivalis agglutinin, GNA) in transgenic potato plants, on parasitism of the phytophagous insect pest Lacanobia oleracea by the gregarious ectoparasitoid Eulophus ..
  83. Becker D, Melkonian M. N-linked glycoproteins associated with flagellar scales in a flagellate green alga: characterization of interactions. Eur J Cell Biol. 1992;57:109-16 pubmed
    ..flagellate green alga Tetraselmis striata (Prasinophyceae) were shown to bind the mannose-specific lectin GNA (Galanthus nivalis agglutinin)...
  84. Wright C, Kaku H, Goldstein I. Crystallization and preliminary X-ray diffraction results of snowdrop (Galanthus nivalis) lectin. J Biol Chem. 1990;265:1676-7 pubmed
    Well-ordered single crystals have been grown for a mannose-specific lectin from snowdrop (Galanthus nivalis) bulbs in the presence of methyl-alpha-D-mannoside...
  85. Akif F, Gabius H, Danguy A. Estrous cycle-related alterations in the expression of glycoconjugates and lectins in the mouse endometrium shown histochemically. Tissue Cell. 1995;27:197-206 pubmed
    ..Stage-specific changes were observed with Galanthus nivalis agglutinin (GNA), Ulex europaeus-I agglutinin (UEA-1), Sambucus nigra agglutinin (SNA), Ricinus communis ..
  86. Saito K, Misaki A, Goldstein I. Purification and characterization of a new mannose-specific lectin from Sternbergia lutea bulbs. Glycoconj J. 1997;14:889-96 pubmed
    ..The primary structure of SLA appears to be quite similar to that of the snow drop (Galanthus nivalis) bulb lectin which is a mannose-binding lectin from the same plant family Amaryllidaceae...
  87. Takahashi M, Tsujioka Y, Yamada T, Tsuboi Y, Okada H, Yamamoto T, et al. Glycosylation of microtubule-associated protein tau in Alzheimer's disease brain. Acta Neuropathol. 1999;97:635-41 pubmed
    ..tau, detected with the monoclonal antibodies AT-8 and anti-tau-2, were also positive with lectin Galanthus nivalis agglutinin (GNA) which recognizes both the N- and O-glycosidically linked saccharides...
  88. Branderhorst H, Ruijtenbeek R, Liskamp R, Pieters R. Multivalent carbohydrate recognition on a glycodendrimer-functionalized flow-through chip. Chembiochem. 2008;9:1836-44 pubmed publisher
    ..Furthermore kinetic and thermodynamic data on binding events can be deduced. Inhibition experiments are also possible with the system as was shown for ConA with alpha-methyl mannose as the inhibitor...
  89. Pusztai A, Ewen S, Grant G, Peumans W, Van Damme E, Rubio L, et al. Relationship between survival and binding of plant lectins during small intestinal passage and their effectiveness as growth factors. Digestion. 1990;46 Suppl 2:308-16 pubmed
    ..six pure plant lectins: PHA (Phaseolus vulgaris); SBL (Glycine maxima); SNA-I and SNA-II (Sambucus nigra); GNA (Galanthus nivalis) and VFL (Vicia faba), covering most sugar specificities found in nature, were studied in vivo...
  90. Bezerra I, Castro L, Neshich G, de Almeida E, de Sa M, Mello L, et al. A corm-specific gene encodes tarin, a major globulin of taro (Colocasia esculenta L. Schott). Plant Mol Biol. 1995;28:137-44 pubmed
    ..protein found in the fruit pulp of Curculigo latifolia and 40% homologous to a mannose-binding lectin from Galanthus nivalis...
  91. Haynes K, Tuinstra P, Hughes T, Wijnands L, Rogers T, Allen A. Purification and characterization of a 93 kDa Aspergillus fumigatus antigen with diagnostic potential. J Med Vet Mycol. 1996;34:421-6 pubmed
    ..of Aspergillus fumigatus NCPF 2109 by single step affinity chromatography using the mannose-specific snowdrop (Galanthus nivalis) lectin coupled to agarose. The carbohydrate moiety contained only mannose and galactose...
  92. Barre A, Van Damme E, Peumans W, Rouge P. Curculin, a sweet-tasting and taste-modifying protein, is a non-functional mannose-binding lectin. Plant Mol Biol. 1997;33:691-8 pubmed
    ..of Curculigo latifolia, was built from the X-ray coordinates of GNA, a mannose-binding lectin from snowdrop (Galanthus nivalis)...