cinnamomum aromaticum


Summary: A plant species of the genus CINNAMOMUM that contains CINNAMATES and has been used in traditional Chinese medicine (DRUGS, CHINESE HERBAL).

Top Publications

  1. Lin C, Wu S, Chang C, Ng L. Antioxidant activity of Cinnamomum cassia. Phytother Res. 2003;17:726-30 pubmed
    ..16 mg/mL vs 0.27 mg/mL) and in xanthine oxidase inhibition test (IC(50) = 0.09 mg/mL vs 0.19 mg/mL). The present study concludes that EECC could be used as a good source of antioxidant in the dietary supplement...
  2. Yang Y, Lee E, Lee H, Lee D, Ahn Y. Repellency of aromatic medicinal plant extracts and a steam distillate to Aedes aegypti. J Am Mosq Control Assoc. 2004;20:146-9 pubmed
    ..Relatively short duration of repellency was observed in P. suffruticosa root bark extract and C. camphora steam distillate. The plants described merit further study as potential mosquito repellent agents...
  3. Koppikar S, Choudhari A, Suryavanshi S, Kumari S, Chattopadhyay S, Kaul Ghanekar R. Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Cancer. 2010;10:210 pubmed publisher
    ..In the present study, we have reported the anti-neoplastic activity of cinnamon in cervical cancer cell line, SiHa...
  4. Sung Y, Yoon T, Jang J, Park S, Jeong G, Kim H. Inhibitory effects of Cinnamomum cassia extract on atopic dermatitis-like skin lesions induced by mite antigen in NC/Nga mice. J Ethnopharmacol. 2011;133:621-8 pubmed publisher
    ..cassia have not been fully verified using scientific tools. This study investigated the effectiveness of C. cassia extract (CCE) as an antiallergic agent in atopic dermatitis model and underlying mechanism...
  5. Zenner L, Callait M, Granier C, Chauve C. In vitro effect of essential oils from Cinnamomum aromaticum, Citrus limon and Allium sativum on two intestinal flagellates of poultry, Tetratrichomonas gallinarum and Histomonas meleagridis. Parasite. 2003;10:153-7 pubmed
    ..The anti-flagellate activity of essential oils obtained from fresh leaves of Cinnamomum aromaticum, Citrus limon pericarps and Allium sativum bulbs was investigated in vitro on Tetratrichomonas gallinarum ..
  6. Verspohl E, Bauer K, Neddermann E. Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro. Phytother Res. 2005;19:203-6 pubmed
    ..The elevation in plasma insulin was direct since a stimulatory in vitro effect of insulin release from INS-1 cells (an insulin secreting cell line) was observed. Thus the cassia extract has a direct antidiabetic potency...
  7. Ngoc T, Lee I, Ha D, Kim H, Min B, Bae K. Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia. J Nat Prod. 2009;72:1205-8 pubmed publisher
    ..The structures of the new compounds were determined by spectroscopic data interpretation. Compounds 1-6 and 8-13 showed strong inhibitory activity against tyrosinase, with IC(50) values ranging from 0.24 to 0.94 mM...
  8. Lee H, Kim B, Kim M. Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase. J Agric Food Chem. 2002;50:7700-3 pubmed
    ..As a naturally occurring therapeutic agent, trans-cinnamaldehyde could be useful for developing new types of NO inhibitors...
  9. Lee S, Lee S, Son D, Lee H, Yoo H, Song S, et al. Inhibitory effect of 2'-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells. Biochem Pharmacol. 2005;69:791-9 pubmed
    ..The present results provided evidence that HCA, among cinnamaledhyde derivatives, has the most inhibitory effect on NO production through inhibition of NF-kappa B activation, and thus can be used as an anti-inflammatory agent...

More Information

Publications114 found, 100 shown here

  1. Zhao X, Zhu J, Mo S, Pan Y, Kong L. Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. J Ethnopharmacol. 2006;103:357-65 pubmed
    ..These results suggested that hypouricemic effects of cassia oil could be explained, at least partly, by inhibiting liver in vivo activities of XDH/XOD...
  2. Giordani R, Regli P, Kaloustian J, Portugal H. Potentiation of antifungal activity of amphotericin B by essential oil from Cinnamomum cassia. Phytother Res. 2006;20:58-61 pubmed
    ..1 microL/mL of essential oil. This potentiation of amphotericin B obtained in vitro may show promise for the development of less toxic and more effective therapies especially for the treatment of HIV infection...
  3. Zhang L, Zhang Z, Fu Y, Yang P, Qin Z, Chen Y, et al. Trans-cinnamaldehyde improves memory impairment by blocking microglial activation through the destabilization of iNOS mRNA in mice challenged with lipopolysaccharide. Neuropharmacology. 2016;110:503-518 pubmed publisher
    ..This study demonstrates that TCA suppressed microglial activation by destabilizing iNOS mRNA, which leads to improved memory impairment in mice suffering neuroinflammation. ..
  4. Zeng J, Zhu H, Lu J, Hu L, Song J, Zhang Y. Two new geranylphenylacetate glycosides from the barks of Cinnamomum cassia. Nat Prod Res. 2017;31:1812-1818 pubmed publisher
    ..Compounds 1-5 were investigated for their immunomodulatory activities, and compounds 1, 3 and 4 showed differential immunosuppressive activities against murine lymphocytes...
  5. Shin W, Shim D, Kim M, Sun X, Koppula S, Yu S, et al. Protective effects of Cinnamomum cassia (Lamaceae) against gout and septic responses via attenuation of inflammasome activation in experimental models. J Ethnopharmacol. 2017;205:173-177 pubmed publisher
    ..CA treatment significantly attenuated danger signals-induced inflammatory responses via regulation of inflammasome activation, substantiating the traditional claims of its use in the treatment of inflammation-related disorders. ..
  6. Chang C, Chang W, Hsu J, Shih Y, Chou S. Chemical composition and tyrosinase inhibitory activity of Cinnamomum cassia essential oil. Bot Stud. 2013;54:10 pubmed publisher
    ..71 ± 0.09 mg/mL and 2.38 ± 0.09 mg/mL, respectively. These results demonstrate that CC-EO and its major component, cinnamaldehyde, possess potent anti-tyrosinase activities and may be a good source for skin-whitening agents. ..
  7. Yuan X, Han L, Fu P, Zeng H, Lv C, Chang W, et al. Cinnamaldehyde accelerates wound healing by promoting angiogenesis via up-regulation of PI3K and MAPK signaling pathways. Lab Invest. 2018;98:783-798 pubmed publisher
    ..Such a small non-peptide molecule may have clinical applications for promoting therapeutic angiogenesis in chronic diabetic wounds and myocardial infarction. ..
  8. Yun J, You J, Kim Y, Kim S, Cho E, Yoon J, et al. In vitro and in vivo safety studies of cinnamon extract (Cinnamomum cassia) on general and genetic toxicology. Regul Toxicol Pharmacol. 2018;95:115-123 pubmed publisher
    ..Further study is needed to clarify the mechanism involved in its induction of liver and kidney injury. ..
  9. Li J, Teng Y, Liu S, Wang Z, Chen Y, Zhang Y, et al. Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway. Oncol Rep. 2016;35:1501-10 pubmed publisher
    ..The mechanisms of action involve the regulation of expression of genes involved in apoptosis, invasion and adhesion via inhibition of the PI3K/Akt signaling pathway. ..
  10. Chen P, Yu J, Lu F, Lin M, Cheng H. Differentiating parts of Cinnamomum cassia using LC-qTOF-MS in conjunction with principal component analysis. Biomed Chromatogr. 2016;30:1449-57 pubmed publisher
    ..Cinnamon twig was also shown to depart from the other clusters. The proposed method provides a fast and efficient means of identifying cinnamon herbs for quality control purposes. Copyright © 2016 John Wiley & Sons, Ltd. ..
  11. Abtew A, Subramanian S, Cheseto X, Kreiter S, Garzia G, Martin T. Repellency of Plant Extracts against the Legume Flower Thrips Megalurothrips sjostedti (Thysanoptera: Thripidae). Insects. 2015;6:608-25 pubmed publisher
    ..In this regard, the specific modes of action of the identified compounds need to be investigated to incorporate them into the existing crop protection strategies. ..
  12. Wang Y, Zhou S, Wang M, Liu S, Hu Y, He C, et al. UHPLC/Q-TOFMS-based metabolomics for the characterization of cold and hot properties of Chinese materia medica. J Ethnopharmacol. 2016;179:234-42 pubmed publisher
    ..There is a strong connection between the cold/hot property of CMMs and lysophosphatidylcholines metabolism. This study offers new insight into CMM properties and their clinical application. ..
  13. Kim J, Ha W, Park J, Lee G, Choi G, Lee S, et al. Influence of herbal combinations on the extraction efficiencies of chemical compounds from Cinnamomum cassia, Paeonia lactiflora, and Glycyrrhiza uralensis, the herbal components of Gyeji-tang, evaluated by HPLC method. J Pharm Biomed Anal. 2016;129:50-59 pubmed publisher
    ..In conclusion, chemical interactions between compositional herbal medicines may occur when herbs are co-decocted. This study provides insight of understanding the herbal interactions in herbal formulae. ..
  14. Sun L, Liu L, Li J, Lv Y, Zong S, Zhou J, et al. The essential oil from the twigs of Cinnamomum cassia Presl inhibits oxytocin-induced uterine contraction in vitro and in vivo. J Ethnopharmacol. 2017;206:107-114 pubmed publisher
    ..Both in vivo and in vitro results suggest that the EOCC possesses significant spasmolytic effect on uterine contraction. Thus, the EOCC yields a possible therapeutic choice for the prevention and treatment of primary dysmenorrhea. ..
  15. Lee W, Wu C, Chuang Y, Tain Y, Chiang P. Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) can ameliorate cyclophosphamide-induced ongoing bladder overactivity and acidic adenosine triphosphate solution-induced hyperactivity on rats prestimulated bladder. J Ethnopharmacol. 2016;184:1-9 pubmed publisher
    ..BWDHW pretreatment can reduce acidic ATP solution-provoked hyperactivity by preventing TRPV1 receptor overexpression in CYP-treated bladder mucosa and inhibiting P2X3 receptor overexpression in naïve bladder mucosa. ..
  16. Luo Q, Wang S, Lu Q, Luo J, Cheng Y. Identification of compounds from the water soluble extract of Cinnamomum cassia barks and their inhibitory effects against high-glucose-induced mesangial cells. Molecules. 2013;18:10930-43 pubmed publisher
  17. Sandner D, Krings U, Berger R. Volatiles from Cinnamomum cassia buds. Z Naturforsch C. 2017;: pubmed publisher
    ..The strongly lignified C. cassia buds combine a high abundance of cinnamaldehyde with comparably low coumarin concentrations (<0.48 mg/g), and provide a large cinnamaldehyde depot for slow release applications...
  18. Fatima M, Zaidi N, Amraiz D, Afzal F. In Vitro Antiviral Activity of Cinnamomum cassia and Its Nanoparticles Against H7N3 Influenza A Virus. J Microbiol Biotechnol. 2016;26:151-9 pubmed publisher
    ..The tested concentrations of extract and nanoparticles (up to 500 ?g/ml) were found non-toxic to Vero cells. The biosynthesized nanoparticles may, hence, be a promising approach to provide treatment against influenza virus infections. ..
  19. Kim G, Lee J, Choi H, Kim S, Kim E, Shim S, et al. Cinnamomulactone, a new butyrolactone from the twigs of Cinnamomum cassia and its inhibitory activity of matrix metalloproteinases. Arch Pharm Res. 2017;40:304-310 pubmed publisher
    ..Among them, compound 1 has been revealed to suppress the gene expression of MMP-3 and interleukin (IL)-1? as well as MMP-1 in tumor necrosis factor (TNF)-? stimulated rheumatoid arthritis synovial fibroblasts. ..
  20. Park S, Sung Y, Jang S, Nho K, Choi G, Kim H. The Korean herbal medicine, Do In Seung Gi-Tang, attenuates atherosclerosis via AMPK in high-fat diet-induced ApoE(-/-) mice. BMC Complement Altern Med. 2016;16:352 pubmed publisher
    ..As a result, the expression of inflammatory factors was reduced. Our data provide evidence that DISGT may have strong therapeutic potential in treating vascular diseases, such as atherosclerosis. ..
  21. Chen G, Yang X, Yang X, Li L, Luo J, Dong H, et al. Jia-Wei-Jiao-Tai-Wan ameliorates type 2 diabetes by improving ? cell function and reducing insulin resistance in diabetic rats. BMC Complement Altern Med. 2017;17:507 pubmed publisher
    ..This study suggests that JWJTW can ameliorate type 2 diabetes by improving ? cell function and reducing insulin resistance in diabetic rats. ..
  22. Sun L, Zong S, Li J, Lv Y, Liu L, Wang Z, et al. The essential oil from the twigs of Cinnamomum cassia Presl alleviates pain and inflammation in mice. J Ethnopharmacol. 2016;194:904-912 pubmed publisher
    ..These results demonstrate that the antinociceptive and anti-inflammatory properties of the EO from the twigs of Cinnamomum cassia Presl, corroborating its use in folk medicine. ..
  23. Kang Y, Seo D, Park S. Phenylpropanoids from cinnamon bark reduced β-amyloid production by the inhibition of β-secretase in Chinese hamster ovarian cells stably expressing amyloid precursor protein. Nutr Res. 2016;36:1277-1284 pubmed publisher
    ..The extract of cinnamon bark contains potentially valuable antiamyloidogenic agents for the prevention and treatment of AD. ..
  24. Uchi H, Yasumatsu M, Morino Koga S, Mitoma C, Furue M. Inhibition of aryl hydrocarbon receptor signaling and induction of NRF2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes. J Dermatol Sci. 2017;85:36-43 pubmed publisher
    ..Through these dual functions, cinnamaldehyde may be beneficial for the treatment of disorders related to oxidative stress such as dioxin intoxication, acne, and vitiligo. ..
  25. Moein E, Hajimehdipoor H, Toliyat T, Choopani R, Hamzeloo Moghadam M. Formulation of an aloe-based product according to Iranian traditional medicine and development of its analysis method. Daru. 2017;25:19 pubmed publisher
    ..0%), LOD & LOQ (0.0053 & 0.0161 ?g/ml). The formulated tablets could be a good substitute for powder and capsules of AF in ITM clinics with a feasible and precise method for its quality control. Ayarij-e-Faiqra formulation. ..
  26. Le T, Beaufay C, Nghiem D, Mingeot Leclercq M, Quetin Leclercq J. In Vitro Anti-Leishmanial Activity of Essential Oils Extracted from Vietnamese Plants. Molecules. 2017;22: pubmed publisher
    ..85 ± 1.65 nL/mL and SI > 10. It contained 86.5% eugenol, which was demonstrated to be effective on Lmm with IC50 of 2.57 ± 0.57 nL/mL and not toxic on mammalian cells, explaining the observed activity. ..
  27. Chang B, Kim D, Kim H, Kim S. Evaluation of estrogenic potential by herbal formula, HPC 03 for in vitro and in vivo. Reproduction. 2018;155:105-115 pubmed publisher
    ..HPC 03 may be a promising candidate for the treatment of menopause, but further research is necessary to determine whether the observed effects also occur in humans. ..
  28. Lakshmi B, Sujatha S, Anand S, Sangeetha K, Narayanan R, Katiyar C, et al. Cinnamic acid, from the bark of Cinnamomum cassia, regulates glucose transport via activation of GLUT4 on L6 myotubes in a phosphatidylinositol 3-kinase-independent manner. J Diabetes. 2009;1:99-106 pubmed publisher
    ..However, the detailed mechanism of action requires further analysis. ..
  29. Ranasinghe P, Galappaththy P, Constantine G, Jayawardena R, Weeratunga H, Premakumara S, et al. Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial. Trials. 2017;18:446 pubmed publisher
    ..Sri Lanka Clinical Trials Registry (SLCTR), identifier: SLCTR/2017/010 ( ). Registered on 5 April 2017; study protocol version 3.1 21 March 2017. ..
  30. Han Y, Jung H, Bae H, Kang J, Park Y. The extract of Cinnamomum cassia twigs inhibits adipocyte differentiation via activation of the insulin signaling pathway in 3T3-L1 preadipocytes. Pharm Biol. 2013;51:961-7 pubmed publisher
    ..These results suggest that CR extract may have therapeutic potential as a natural agent for the improvement of T2D via regulation of the insulin-dependent signaling pathway. ..
  31. Campana R, Casettari L, Fagioli L, Cespi M, Bonacucina G, Baffone W. Activity of essential oil-based microemulsions against Staphylococcus aureus biofilms developed on stainless steel surface in different culture media and growth conditions. Int J Food Microbiol. 2017;241:132-140 pubmed publisher
    ..The obtained data suggest the potential use of EOs, alone or in combination, for the formulation of sanitizers as alternative or in support in the disinfection of contaminated surfaces. ..
  32. Shakeel M, Jabeen F, Iqbal R, Chaudhry A, Zafar S, Ali M, et al. Assessment of Titanium Dioxide Nanoparticles (TiO2-NPs) Induced Hepatotoxicity and Ameliorative Effects of Cinnamomum cassia in Sprague-Dawley Rats. Biol Trace Elem Res. 2018;182:57-69 pubmed publisher
    ..It aided in the recovery of the antioxidant system as well as protective role in histological damages and some haematological parameters in the rat liver treated with titanium dioxide nanoparticles or titanium dioxide bulk salt. ..
  33. Bub S, Brinckmann J, Cicconetti G, Valentine B. Efficacy of an herbal dietary supplement (Smooth Move) in the management of constipation in nursing home residents: A randomized, double-blind, placebo-controlled study. J Am Med Dir Assoc. 2006;7:556-61 pubmed
    ..017). Smooth Move herbal tea, when added to the standard treatment regimen for nursing home residents with chronic constipation, increased the average number of bowel movements compared to the addition of a placebo tea. ..
  34. Wu C, Zhuang Y, Jiang S, Tian F, Teng Y, Chen X, et al. Cinnamaldehyde induces apoptosis and reverses epithelial-mesenchymal transition through inhibition of Wnt/?-catenin pathway in non-small cell lung cancer. Int J Biochem Cell Biol. 2017;84:58-74 pubmed publisher
  35. Lee S, Siaw J, Kang H. Stimulatory Effects of Cinnamon Extract (Cinnamomum cassia) during the Initiation Stage of 3T3-L1 Adipocyte Differentiation. Foods. 2016;5: pubmed publisher
  36. Park G, Song H, Park S, Son H, Um Y, Kim H, et al. Cytotoxic activity of the twigs of Cinnamomum cassia through the suppression of cell proliferation and the induction of apoptosis in human colorectal cancer cells. BMC Complement Altern Med. 2018;18:28 pubmed publisher
    ..From these findings, TC-HW has potential to be a candidate for the development of chemoprevention or therapeutic agents for human colorectal cancer. ..
  37. Yang Z, Pei J, Liu R, Cheng J, Wan D, Hu R. [Study on relative bioavailability of ferulic acid of combination Radix Angelicae Sinensis and Cortex Cinnamomi in mice]. Zhongguo Zhong Yao Za Zhi. 2006;31:1012-5 pubmed
    ..75%. By the statistical analysis, Cortex Cinnamomi combined with Radix Angelicae Sinensis can increase the relative bioavailability of ferulic acid. ..
  38. Lv C, Yuan X, Zeng H, Liu R, Zhang W. Protective effect of cinnamaldehyde against glutamate-induced oxidative stress and apoptosis in PC12 cells. Eur J Pharmacol. 2017;815:487-494 pubmed publisher
    ..These results indicate that cinnamaldehyde exists a potential protective effect against glutamate-induced oxidative stress and apoptosis in PC12 cells. ..
  39. Lafeuille J, Buniak M, Vioujas M, Lefevre S. Natural formation of styrene by cinnamon mold flora. J Food Sci. 2009;74:M276-83 pubmed publisher
    ..A standardized inoculation with the 3 mold species was carried out on 10 g cinnamon samples of various origins followed by a 10-d incubation and highlighting styrene production except for Sri Lanka origin. ..
  40. Lim C, Kim E, Lee H, Soh Y, Sohn Y, Kim S, et al. Protective effects of Cinnamomum cassia Blume in the fibrogenesis of activated HSC-T6 cells and dimethylnitrosamine-induced acute liver injury in SD rats. Biosci Biotechnol Biochem. 2010;74:477-83 pubmed
    ..We suggest that CC inhibits fibrogenesis, followed by HSC-T6 cell activation and increased restoration of liver function, ultimately resulting in acute liver injury. ..
  41. Hwang H, Jeon H, Ock J, Hong S, Han Y, Kwon B, et al. 2'-Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharide-induced microglial activation. J Neuroimmunol. 2011;230:52-64 pubmed publisher
    ..Our results suggest that HCA/BCA be anti-inflammatory and neuroprotective in the CNS by targeting LRP1, and may have a therapeutic potential against neuroinflammatory diseases. ..
  42. Mehta M, Kumar A. Green and Efficient Processing of Cinnamomum cassia Bark by Using Ionic Liquids: Extraction of Essential Oil and Construction of UV-Resistant Composite Films from Residual Biomass. Chem Asian J. 2017;12:3150-3155 pubmed publisher
    ..The films showed excellent UV-light resistance and mechanical properties, thereby making it a material suitable for packaging and light-sensitive applications. ..
  43. Huang X, Zhong G, Zhang X, Zhang Y. [Determination of aurantio-obtusin and chrysophanol in cassiae semen by HPLC]. Zhongguo Zhong Yao Za Zhi. 2010;35:2065-7 pubmed
    ..The average recover were 100.3% (RSD 3.1%), and 99.5% (RSD 2.5%) respectively. This method is specific, accurate and reproducible, and can be used for the assay of Cassiae Semen in the new edition of Chinese pharmacopoeia. ..
  44. Patil M, Choudhari A, Pandita S, Islam M, Raina P, Kaul Ghanekar R. Cinnamaldehyde, Cinnamic Acid, and Cinnamyl Alcohol, the Bioactives of Cinnamomum cassia Exhibit HDAC8 Inhibitory Activity: An In vitro and In silico Study. Pharmacogn Mag. 2017;13:S645-S651 pubmed publisher
    ..Recently, plant secondary metabolites, particularly phenolic compounds, have been shown to possess HDAC inhibitory activity...
  45. Akram M, Rashid A. Anti-coagulant activity of plants: mini review. J Thromb Thrombolysis. 2017;44:406-411 pubmed publisher
    ..This review shows that medicinal plants should be prescribed with care to patients on anticoagulant therapy. ..
  46. Fu Y, Yang P, Zhao Y, Zhang L, Zhang Z, Dong X, et al. trans-Cinnamaldehyde Inhibits Microglial Activation and Improves Neuronal Survival against Neuroinflammation in BV2 Microglial Cells with Lipopolysaccharide Stimulation. Evid Based Complement Alternat Med. 2017;2017:4730878 pubmed publisher
    ..Our results suggest that TCA, a natural product, has the potential of being used as a therapeutic agent against neuroinflammation for ameliorating neurodegenerative disorders. ..
  47. Reddy A, Seo J, Ryu S, Kim Y, Kim Y, Min K, et al. Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia. Planta Med. 2004;70:823-7 pubmed
    ..Both trans-cinnamaldehyde and 2-methoxycinnamaldehyde inhibited LPS-induced DNA binding activity of NF-KB in addition to NF-KB transcription-al activity. ..
  48. Lv G, Huang W, Yang F, Li J, Li S. Pressurized liquid extraction and GC-MS analysis for simultaneous determination of seven components in Cinnamomum cassia and the effect of sample preparation. J Sep Sci. 2010;33:2341-8 pubmed publisher
    ..cassia. The contents of the investigated components were significantly variant and cinnamaldehyde is the most abundant compound, but safrole was not detected in all samples. ..
  49. Yang C, Li R, Chuang L. Antioxidant activity of various parts of Cinnamomum cassia extracted with different extraction methods. Molecules. 2012;17:7294-304 pubmed publisher
    ..Based on the results, the ethanol extracts of Cinnamon barks have potential value as an antioxidant substitute and this study also provide a better technique to extract the natural antioxidant substances from C. cassia. ..
  50. Lee M, Park H, Chung H, Kim W, Lee S. Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of ?-catenin signaling. J Nat Prod. 2013;76:1278-84 pubmed publisher
    ..The suppression of the Wnt/?-catenin signaling pathway is a plausible mechanism of action underlying the antiproliferative and antitumor activity of 1 in human colorectal cancer cells. ..
  51. Zou C, Yan H, Fang H. [Chromatographic fingerprint peak matching of Semen Cassiae by asymptotic window orthoganality projection analytical method]. Zhongguo Zhong Yao Za Zhi. 2009;34:2876-9 pubmed
    ..The asymptotic window orthogonal projection analytical method can progress the matching of different fingerprint collection of illustrative plates peak matching well and truly. ..
  52. Tian F, Yu C, Ye W, Wang Q. Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer. Biochem Biophys Res Commun. 2017;493:1260-1266 pubmed publisher
    ..Above all, we characterized a new mechanism mediated by hsa_circ_0043256/miR-1252/ITCH axis in CA function against NSCLC, providing a novel insight into lung cancer therapy. ..
  53. Taguchi Y, Hasumi Y, Abe S, Nishiyama Y. The effect of cinnamaldehyde on the growth and the morphology of Candida albicans. Med Mol Morphol. 2013;46:8-13 pubmed publisher
    ..These findings indicate that cinnamaldehyde has both fungistatic and fungicidal activities against C. albicans and affects the structure of the cells. ..
  54. Abraham K, Pfister M, Wöhrlin F, Lampen A. Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: a four-way crossover study in human volunteers. Mol Nutr Food Res. 2011;55:644-53 pubmed publisher
    ..Heavy consumption of this spice may result in a dose exceeding the tolerable daily intake (TDI). In this context, the question was raised whether coumarin in the plant matrix of cinnamon has the same bioavailability as isolated coumarin...
  55. Jung Y, Kwon S, Hong S, Lee S, Kim S, Lee S, et al. 5-HT(1A) receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia. Pharmacol Biochem Behav. 2012;103:367-72 pubmed publisher
    ..Taken together, the anxiolytic-like effect of the 50% EtOH extract of C. cassia might be mediated by region specific change of 5-HT(1A) receptors in the dorsal raphe nucleus...
  56. Kim J. Extraction time and temperature affect the extraction efficiencies of coumarin and phenylpropanoids from Cinnamomum cassia bark using a microwave-assisted extraction method. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1063:196-203 pubmed publisher
    ..cassia bark when a water-based MAE method was used. This study provides a novel approach to the preparation of the water extract of C. cassia bark using MAE. ..
  57. He Z, Qiao C, Han Q, Cheng C, Xu H, Jiang R, et al. Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography. J Agric Food Chem. 2005;53:2424-8 pubmed
    ..cassia. It is suggested that five characteristic peaks by HPLC are suitable for distinguishing genuine cassia bark from the adulterants and could be applied in the quality control of this commodity...
  58. Kim S, Kim H, Koh Y, Clark J, Ahn Y. Toxicity of spray and fumigant products containing cassia oil to Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae). Pest Manag Sci. 2006;62:768-74 pubmed
    ..097 m(3) at 4 days after application. Two fumigant devices gave 88% mortality in a space of 1.73 m(3). Cassia oil applied as sprays or in fumigant devices appears to provide effective protection of humans from house dust mites...
  59. Dhyani A, Arora N, Gaur S, Jain V, Sridhara S, Singh B. Analysis of IgE binding proteins of mesquite (Prosopis juliflora) pollen and cross-reactivity with predominant tree pollens. Immunobiology. 2006;211:733-40 pubmed
    ..juliflora. The findings suggest that purification of cross-reactive allergens will be helpful for diagnosis and immunotherapy of tree pollen allergic patients...
  60. Suppapitiporn S, Kanpaksi N, Suppapitiporn S. The effect of cinnamon cassia powder in type 2 diabetes mellitus. J Med Assoc Thai. 2006;89 Suppl 3:S200-5 pubmed
    ..Cinnamon is expected to have some degree of anti-diabetic efficacy without troublesome side effects. The objective of the present study was to investigate the anti-diabetic effect of cinnamon cassia powder in type 2 diabetic patients..
  61. Yu T, Lee S, Yang W, Jang H, Lee Y, Kim T, et al. The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action. J Ethnopharmacol. 2012;139:566-73 pubmed publisher
    ..However, the anti-inflammatory mechanism of Cinnamomum cassia has not been fully elucidated. This study examined the anti-inflammatory mechanism of 95% ethanol extract (Cc-EE) of Cinnamomum cassia...
  62. Hwa J, Jin Y, Lee Y, Ko Y, Kim Y, Shi L, et al. 2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction. J Ethnopharmacol. 2012;139:605-15 pubmed publisher
    ..Cinnamomum cassia Blume has been used as a traditional Chinese herbal medicine for alleviation of fever, inflammation, chronic bronchitis, and to improve blood circulation...
  63. Kocevski D, Du M, Kan J, Jing C, Lačanin I, Pavlović H. Antifungal effect of Allium tuberosum, Cinnamomum cassia, and Pogostemon cablin essential oils and their components against population of Aspergillus species. J Food Sci. 2013;78:M731-7 pubmed publisher
    ..cassia in different food systems due to its strong inhibitory effect against tested Aspergillus species. In real food system (table grapes), C. cassia essential oil exhibited stronger antifungal activity compared to cinnamaldehyde...
  64. Zada W, Zeeshan S, Bhatti H, Mahmood W, Rauf K, Abbas G. Cinnamomum cassia: an implication of serotonin reuptake inhibition in animal models of depression. Nat Prod Res. 2016;30:1212-4 pubmed publisher
    ..The aforementioned results are similar to that caused by fluoxetine. The standardised methanolic extract of C. cassia demonstrated antidepressant activity that can be attributed to rise in serotonin levels...
  65. Lee J, Lee J, Cho W, Han J, Ma J. Herbal composition of Cinnamomum cassia, Pinus densiflora, Curcuma longa and Glycyrrhiza glabra prevents atherosclerosis by upregulating p27 (Kip1) expression. BMC Complement Altern Med. 2016;16:253 pubmed publisher
    ..These results indicate that Kiom-18 exerts anti-atherosclerotic effects by inhibiting VSMC proliferation via G0/G1 arrest, which upregulates p27(Kip1) expression. ..
  66. Kim S, Hyun S, Choung S. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors. 2006;26:209-19 pubmed
    ..Extract treatment also significantly decreased lipid peroxidation. Cinnamomi cassiae and Rhodiola rosea extracts may be effective for correcting hyperglycemia and preventing diabetic complications...
  67. Lungarini S, Aureli F, Coni E. Coumarin and cinnamaldehyde in cinnamon marketed in Italy: a natural chemical hazard?. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008;25:1297-305 pubmed publisher
    ..As far as cinnamon-containing foods are concerned, the samples often exceeded the maximum level fixed in the European Flavourings Directive of 2 mg kg(-1)...
  68. Liu C, Zhong S, Chen R, Wu Y, Zhu X. Two new compounds from the dried tender stems of Cinnamomum cassia. J Asian Nat Prod Res. 2009;11:845-9 pubmed publisher
    ..7 microM. Compounds 3-8 were isolated from the title plant for the first time...
  69. Diao Y, Wang R, Zhang C, Chen J, Liu B. A new comprehensive procedure for the quality control of Semen Cassiae and its application in evaluating commercially available material in China. Chin J Nat Med. 2013;11:433-41 pubmed publisher
    ..To establish a more comprehensive and suitable procedure for the quality control of Semen Cassiae which can be used to supplement the evaluation procedure adopted by the Pharmacopoeia of the Peoples Republic of China...
  70. Chou S, Chang W, Chang C, Hsu S, Lin Y, Shih Y. Cinnamomum cassia essential oil inhibits ?-MSH-induced melanin production and oxidative stress in murine B16 melanoma cells. Int J Mol Sci. 2013;14:19186-201 pubmed publisher
    ..Therefore, CC-EO may be a good source of skin-whitening agents and may have potential as an antioxidant in the future development of complementary and alternative medicine-based aromatherapy...
  71. Xu Y, Wei L, Wang Y. [Determination of cinnamic acid in Cinnamomum cassia presl after compatibility in Coptis chinensis Franch]. Zhongguo Zhong Yao Za Zhi. 2001;26:47-9 pubmed
    ..Studying changes of chemical constituents of Cinnamomum cassia after compatibility in Coptis chinensis; determining the amount of cinnamic acid in the decoction...
  72. Gao Q, Chen X, Bi K. Comparative pharmacokinetic behavior of glycyrrhetic acid after oral administration of glycyrrhizic acid and Gancao-Fuzi-Tang. Biol Pharm Bull. 2004;27:226-8 pubmed
    ..0+/-2.0 h and 40.9+/-9.6 microg.h/ml, respectively). The results suggest the increased effect of GA after oral administration of KF in comparison with GL...
  73. Wu S, Ng L. MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells. Food Chem Toxicol. 2007;45:2446-53 pubmed
    ..These results suggest that p53 induction and MAPK signaling pathways are required for Cin-mediated apoptosis in PLC/PRF/5 cells...
  74. Choi D, Baek Y, Huh J, Ko J, Woo H, Lee J, et al. Stimulatory effect of Cinnamomum cassia and cinnamic acid on angiogenesis through up-regulation of VEGF and Flk-1/KDR expression. Int Immunopharmacol. 2009;9:959-67 pubmed publisher
    ..These data suggest that CCE and its active compound CA induce angiogenesis in vivo and in vitro, and this pathway is related with VEGF and Flk-1/KDR expression of endothelial cells...
  75. Woehrlin F, Fry H, Abraham K, Preiss Weigert A. Quantification of flavoring constituents in cinnamon: high variation of coumarin in cassia bark from the German retail market and in authentic samples from indonesia. J Agric Food Chem. 2010;58:10568-75 pubmed publisher
    ..Interestingly, a high variation was observed in one of the trees, whereas no coumarin was detected in the samples of two other trees. In conclusion, coumarin levels in cassia cinnamon can vary widely even within a single tree...
  76. Peter K, Schinnerl J, Felsinger S, Brecker L, Bauer R, Breiteneder H, et al. A novel concept for detoxification: complexation between aconitine and liquiritin in a Chinese herbal formula ('Sini Tang'). J Ethnopharmacol. 2013;149:562-9 pubmed publisher
    ..We now demonstrate that Glycyrrhiza uralensis, which is often used in Traditional Chinese Medicine for detoxification, reduces the concentration of free aconitine in decoctions by forming a complex between liquiritin and aconitine...
  77. Tanaka N, Sekiya N, Hattori M, Goto H, Shibahara N, Shimada Y, et al. Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat. Phytomedicine. 2003;10:122-6 pubmed
    ..01% acetic acid; B: methanol with 0.01% acetic acid) in a linear gradient at a flow-rate of 1.0 ml/min, and fluorescence detection at excitation and emission wavelengths of 220 and 327 nm...
  78. Xu H, Zhang J, Zheng M, Yuan W. [Isolation of genomic DNA from Cinnamomum cassia Presl]. Zhong Yao Cai. 2004;27:326-9 pubmed
    ..To extract high-quality DNA for RAPD and other molecular biology research from Chinese traditional medicine Cinnamomum cassia Presl....
  79. Kwon K, Kim E, Jeong E, Lee Y, Lee Y, Park J, et al. Cortex cinnamomi extract prevents streptozotocin- and cytokine-induced beta-cell damage by inhibiting NF-kappaB. World J Gastroenterol. 2006;12:4331-7 pubmed
    ..To clarify the mechanism underlying the anti-diabetic activities of cortex cinnamomi extract (CCE)...
  80. Shen L, Li H, Zhou Y, Gu S, Lou Y. [Ovicidal activity of nine essential oils against Chrysomya megacephara in bacon and kipper]. Ying Yong Sheng Tai Xue Bao. 2007;18:2343-6 pubmed
    ..33%) was 0.281 mg x ml(-1), being a little higher than the LC50 of C. cassia oil, suggesting that cinamaldehyde was the main ovicidal component of C. cassia oil and could replace the latter as an ovicide against harmful flies...
  81. Killday K, Davey M, Glinski J, Duan P, Veluri R, Proni G, et al. Bioactive A-type proanthocyanidins from Cinnamomum cassia. J Nat Prod. 2011;74:1833-41 pubmed publisher
    ..Proanthocyanidins (1-4) possess significant in vitro inhibitory activity against cyclooxygenase-2 (COX-2) at micromolar concentrations...
  82. Raffo A, D Aloise A, Magrì A, Leclercq C. Quantitation of tr-cinnamaldehyde, safrole and myristicin in cola-flavoured soft drinks to improve the assessment of their dietary exposure. Food Chem Toxicol. 2013;59:626-35 pubmed publisher
    ..The lowest MOE values, from 1900 to 3000, were observed for children and teen agers in the United Kingdom and Ireland. ..
  83. Aguiar T, Vidal C, Phansalkar R, Todorova I, Napolitano J, McAlpine J, et al. Dentin biomodification potential depends on polyphenol source. J Dent Res. 2014;93:417-22 pubmed publisher
    ..The findings provide clear evidence that the dentin bioactivities of PACs are source dependent, resulting from a combination of concentration and specific chemical constitution of the complex PAC mixtures. ..
  84. Sun H, Li T, Sun L, Qiu Y, Huang B, Yi B, et al. Inhibitory effect of traditional Chinese medicine Zi-Shen Pill on benign prostatic hyperplasia in rats. J Ethnopharmacol. 2008;115:203-8 pubmed
    ..These results suggest that ZSPE has a definite inhibitory effect on BPH and might be an alternative medicine for treatment of human BPH...
  85. Kim H, Yun Y, Ahn Y. Fumigant toxicity of cassia bark and cassia and cinnamon oil compounds to Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae). Exp Appl Acarol. 2008;44:1-9 pubmed publisher
    ..farinae, the test compounds described were much more effective in closed--but not in open--containers, indicating that the effect of these compounds was largely a result of action in the vapour phase...
  86. Lu Z, Jia Q, Wang R, Wu X, Wu Y, Huang C, et al. Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks. Phytomedicine. 2011;18:298-302 pubmed publisher
    ..These results suggest that both A- and B-type procyanidin oligomers in different Cinnamon species have hypoglycemic activities and may improve insulin sensitivity in type 2 DM...
  87. Wickenberg J, Lindstedt S, Berntorp K, Nilsson J, Hlebowicz J. Ceylon cinnamon does not affect postprandial plasma glucose or insulin in subjects with impaired glucose tolerance. Br J Nutr. 2012;107:1845-9 pubmed publisher
    ..cassia by C. zeylanicum or the use of aqueous extracts of C. cassia to lower coumarin exposure. However, the positive effects seen with C. cassia in subjects with poor glycaemic control would then be lost...
  88. Guoruoluo Y, Zhou H, Zhou J, Zhao H, Aisa H, Yao G. Isolation and Characterization of Sesquiterpenoids from Cassia Buds and Their Antimicrobial Activities. J Agric Food Chem. 2017;65:5614-5619 pubmed publisher
    ..The present investigation indicated that sesquiterpenoids from cassia buds might be used as potential antimicrobial agents to preserve food...
  89. Mi Z, Liu S, Cao Y, Yang X. [Adjustive effect of yi qi tong lin chongji on the three growth factors in rats prostatic tissues]. Zhongguo Zhong Yao Za Zhi. 2003;28:653-5 pubmed
    ..To study the mechanisim of Yi Qi Tong Lin Chingji in treating benign prostatic hyperplasia...
  90. Zhou J, Li C, Huo H, Kang X, Li L, Jiang N, et al. [Effect of guizhi decoction on PKA and PKC activities of hypothalamus in fever rats]. Zhongguo Zhong Yao Za Zhi. 2006;31:66-9 pubmed
    ..To investigate the changes of the activity of both protein kinase A and C and the mechanisms of antipyretic action of Guizhi decoction...
  91. Blevins S, Leyva M, Brown J, Wright J, Scofield R, Aston C. Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes. Diabetes Care. 2007;30:2236-7 pubmed
  92. Dugoua J, Seely D, Perri D, Cooley K, Forelli T, Mills E, et al. From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark. Can J Physiol Pharmacol. 2007;85:837-47 pubmed
    ..pylori infection. Common cinnamon showed weak to very weak evidence of efficacy in treating oral candidiasis in HIV patients and chronic salmonellosis...