uncaria

Summary

Summary: A plant genus of the family RUBIACEAE. Members contain uncarine and other cytotoxic and hypotensive oxindole alkaloids.

Top Publications

  1. Shi J, Yu J, Chen X, Xu R. Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline. Acta Pharmacol Sin. 2003;24:97-101 pubmed
    The pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline extracted from Uncaria rhynchophylla Miq Jacks were reviewed...
  2. Carvalho M, Penido C, Siani A, Valente L, Henriques M. Investigations on the anti-inflammatory and anti-allergic activities of the leaves of Uncaria guianensis (Aublet) J. F. Gmelin. Inflammopharmacology. 2006;14:48-56 pubmed
    b>Uncaria guianensis (Aublet) J. F. Gmelin is an herbal medicine from tropical areas of South and Central America. We investigated the anti-inflammatory and anti-allergic properties of an ethanolic extract of U...
  3. Sheng Y, Bryngelsson C, Pero R. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000;69:115-26 pubmed
    Female W/Fu rats were gavaged daily with a water-soluble extract (C-MED-100) of Uncaria tomentosa supplied commercially by CampaMed at the doses of 0, 5, 10, 20, 40 and 80 mg/kg for 8 consecutive weeks...
  4. Tang N, Liu C, Su S, Jan Y, Hsieh C, Cheng C, et al. Uncaria rhynchophylla (miq) Jack plays a role in neuronal protection in kainic acid-treated rats. Am J Chin Med. 2010;38:251-63 pubmed
    b>Uncaria rhynchophylla (Miq) Jack (UR) is one of many Chinese herbs. Our previous studies have shown that UR has both anticonvulsive and free radical-scavenging activities in kainic acid (KA)-treated rats...
  5. Heitzman M, Neto C, Winiarz E, Vaisberg A, Hammond G. Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae). Phytochemistry. 2005;66:5-29 pubmed
    The Uncaria genus is an important source of medicinal natural products, particularly alkaloids and triterpenes...
  6. Liu W, Zhang Z, Zhao X, Gao Y. [Protective effect of Uncaria rhynchophylla total alkaloids pretreatment on hippocampal neurons after acute hypoxia]. Zhongguo Zhong Yao Za Zhi. 2006;31:763-5 pubmed
    To investigate the effect of Uncaria rhynchophylla total alkaloids (RTA) pretreatment on the voltage-gated sodium currents of the rat hippocampal neurons after acute hypoxia.
  7. Yuan D, Ma B, Wu C, Yang J, Zhang L, Liu S, et al. Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. J Nat Prod. 2008;71:1271-4 pubmed publisher
    ..acid B (1) and 18,19-dehydrocorynoxinic acid (2), were isolated from the CHCl3 extract of the leaves of Uncaria rhynchophylla, together with four known rhynchophylline-type alkaloids, corynoxeine (3), isocorynoxeine (4), ..
  8. Lee J, Son D, Lee P, Kim D, Shin M, Jang M, et al. Protective effect of methanol extract of Uncaria rhynchophylla against excitotoxicity induced by N-methyl-D-aspartate in rat hippocampus. J Pharmacol Sci. 2003;92:70-3 pubmed
    b>Uncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine...
  9. Zhang W, Chen C, Sim S, Kwan C. In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel). Naunyn Schmiedebergs Arch Pharmacol. 2004;369:232-8 pubmed
    Rhynchophylline (Rhy) and isorhynchophylline (Isorhy), indole alkaloids from Uncaria hooks, reportedly exert hypotensive and vasodilatory effects, but the mechanism of action is unclear...

More Information

Publications110 found, 100 shown here

  1. Na M, Kim Y, Min B, Bae K, Kamiryo Y, Senoo Y, et al. Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Uncaria sinensis Havil. J Ethnopharmacol. 2004;95:127-32 pubmed
    The ethanol extract from the hooks and stems of Uncaria sinensis Havil (Rubiaceae) exhibited significant inhibitory activity on oxidative stress and the age-dependent shortening of the telomeric DNA length...
  2. Lee J, Yoo H, Suh Y, Jung J, Kim J. Structure-activity relationship of pentacylic triterpene esters from Uncaria rhynchophylla as inhibitors of phospholipase Cgamma1. Planta Med. 2008;74:1481-7 pubmed publisher
    ..relationship of 3beta-hydroxy-27- P- E-coumaroyloxyurs-12-en-28-oic acid ( 7), a triterpene ester isolated from UNCARIA RHYNCHOPHYLLA as a phospholipase Cgamma1 inhibitor, was undertaken with a view toward elucidating its chemical ..
  3. Chou C, Gong C, Chao C, Lin C, Kwan C, Hsieh C, et al. Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels. J Nat Prod. 2009;72:830-4 pubmed publisher
    Rhynchophylline (1), a neuroprotective agent isolated from the traditional Chinese medicinal herb Uncaria rhynchophylla, was shown to affect voltage-gated K(+) (Kv) channel slow inactivation in mouse neuroblastoma N2A cells...
  4. Hsieh C, Ho T, Su S, Lo W, Liu C, Tang N. Uncaria rhynchophylla and Rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-kappaB activity in kainic acid-treated rats. Am J Chin Med. 2009;37:351-60 pubmed
    Our previous studies have shown that Uncaria rhynchophylla (UR) can reduce epileptic seizures...
  5. Imamura S, Tabuchi M, Kushida H, Nishi A, Kanno H, Yamaguchi T, et al. The blood-brain barrier permeability of geissoschizine methyl ether in Uncaria hook, a galenical constituent of the traditional Japanese medicine yokukansan. Cell Mol Neurobiol. 2011;31:787-93 pubmed publisher
    Geissoschizine methyl ether (GM) in Uncaria hook, a galenical constituent of yokukansan is thought to be one of active components in the psychotropic effect of yokukansan, a traditional Japanese medicine (kampo medicine)...
  6. Sheng Y, Li L, Holmgren K, Pero R. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine. 2001;8:275-82 pubmed
    The Uncaria tomentosa water extracts (C-Med-100) have been shown to enhance DNA repair, mitogenic response and leukocyte recovery after chemotherapy-induced DNA damage in vivo...
  7. Sekiya N, Shimada Y, Shibahara N, Takagi S, Yokoyama K, Kasahara Y, et al. Inhibitory effects of Choto-san (Diao-teng-san), and hooks and stems of Uncaria sinensis on free radical-induced lysis of rat red blood cells. Phytomedicine. 2002;9:636-40 pubmed
    The present study is designed to test our hypothesis that the ingestion of Uncaria sinensis (US), the main medicinal plant of Choto-san (Diao-teng-san, CS), would protect red blood cell (RBC) membrane from free radical-induced oxidation ..
  8. Lee J, Son D, Lee P, Kim S, Kim H, Kim C, et al. Alkaloid fraction of Uncaria rhynchophylla protects against N-methyl-D-aspartate-induced apoptosis in rat hippocampal slices. Neurosci Lett. 2003;348:51-5 pubmed
    b>Uncaria rhynchophylla is a medicinal herb which has sedative and anticonvulsive effects and has been applied in the treatment of epilepsy in Oriental medicine. In this study, the effect of alkaloid fraction of U...
  9. De Martino L, Martinot J, Franceschelli S, Leone A, Pizza C, De Feo V. Proapoptotic effect of Uncaria tomentosa extracts. J Ethnopharmacol. 2006;107:91-4 pubmed
    b>Uncaria tomentosa ("Uña de gato") (Rubiaceae) is widely used in South America for treatment of gastritis, arthritis, cancer and inflammatory conditions...
  10. Fujiwara H, Iwasaki K, Furukawa K, Seki T, He M, Maruyama M, et al. Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins. J Neurosci Res. 2006;84:427-33 pubmed
    ..on fibril formation of both Abeta(1-40) and Abeta(1-42) in concentration-dependent manners; in particular, Uncaria rhynchophylla inhibited Abeta aggregation most intensively...
  11. Nakazawa T, Banba K, Hata K, Nihei Y, Hoshikawa A, Ohsawa K. Metabolites of hirsuteine and hirsutine, the major indole alkaloids of Uncaria rhynchophylla, in rats. Biol Pharm Bull. 2006;29:1671-7 pubmed
    The metabolic fate of hirsuteine (HT) and hirsutine (HS), the major indole alkaloids of Uncaria rhynchophylla, was investigated using rats...
  12. Shim J, Kim H, Ju M, Choi J, Jeong S, Oh M. Effects of the hook of Uncaria rhynchophylla on neurotoxicity in the 6-hydroxydopamine model of Parkinson's disease. J Ethnopharmacol. 2009;126:361-5 pubmed publisher
    While the hook of Uncaria rhynchophylla (URH) is a traditional herb used in northeast Asia for the treatment of Parkinson's disease (PD)-like symptoms such as tremor, it has not been experimentally evaluated in a PD model.
  13. Jang J, Kim H, Kim Y, Hong J, Choi Y, Choi Y, et al. Hexane extract from Uncaria sinensis exhibits anti-apoptotic properties against glutamate-induced neurotoxicity in primary cultured cortical neurons. Int J Mol Med. 2012;30:1465-72 pubmed publisher
    We explored the neuroprotective effects of a hexane extract from Uncaria sinensis (HEUS) against glutamate-induced toxicity focusing on its anti-apoptotic mechanism in primary cultured cortical neurons...
  14. Akesson C, Lindgren H, Pero R, Leanderson T, Ivars F. An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death. Int Immunopharmacol. 2003;3:1889-900 pubmed
    Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses...
  15. Umeyama A, Yahisa Y, Okada M, Okayama E, Uda A, Shoji N, et al. Triterpene esters from Uncaria rhynchophylla drive potent IL-12-dependent Th1 polarization. J Nat Med. 2010;64:506-9 pubmed publisher
    ..that two triterpene esters, uncarinic acid C (1) and uncarinic acid D (2), which are isolated from the hooks of Uncaria rhynchophylla, activate phenotypic and cytokine production alterations in DC...
  16. Lo W, Tsai F, Liu C, Tang N, Su S, Lin S, et al. Uncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysis. Am J Chin Med. 2010;38:745-59 pubmed
    b>Uncaria rhynchophylla (Miq) Jack (UR) is a traditional Chinese herb and is used for the treatment of convulsive disorders, including epilepsy...
  17. Park S, Kim J, Park S, Bae S, Choi Y, Hong J, et al. Protective effect of hexane extracts of Uncaria sinensis against photothrombotic ischemic injury in mice. J Ethnopharmacol. 2011;138:774-9 pubmed publisher
    b>Uncaria sinensis (US) has been used in traditional Korean medicine to treat vascular disease and to relieve various neurological symptoms.
  18. Taniguchi S, Kuroda K, Doi K, Inada K, Yoshikado N, Yoneda Y, et al. [Evaluation of gambir quality based on quantitative analysis of polyphenolic constituents]. Yakugaku Zasshi. 2007;127:1291-300 pubmed
    Gambir (asen'yaku in Japanese), an aqueous extract of leaves and young twigs of Uncaria gambir Roxb., has traditionally been used as a treatment for diarrhea and dysentery as an internal medicine and for sore throat as a gargle...
  19. Kim T, Lee J, Lee J, Yu J, Hwang B, Ye S, et al. Corynoxeine isolated from the hook of Uncaria rhynchophylla inhibits rat aortic vascular smooth muscle cell proliferation through the blocking of extracellular signal regulated kinase 1/2 phosphorylation. Biol Pharm Bull. 2008;31:2073-8 pubmed
    ..b>Uncaria rhynchophylla is traditional Chinese herb that has been applied to the treatment of convulsive disorders, such as ..
  20. Tan S, Yong J, Teo C, Ge L, Chan Y, Hew C. Determination of metabolites in Uncaria sinensis by HPLC and GC-MS after green solvent microwave-assisted extraction. Talanta. 2011;83:891-8 pubmed publisher
    b>Uncaria sinensis (Oliv.) Havil (Rubiaceae) has been used as an important Traditional Chinese Medicine (TCM) herb for the treatment of fevers and various nervous disorders...
  21. Xian Y, Lin Z, Zhao M, Mao Q, Ip S, Che C. Uncaria rhynchophylla ameliorates cognitive deficits induced by D-galactose in mice. Planta Med. 2011;77:1977-83 pubmed publisher
    The stem with hooks of Uncaria rhynchophylla is a component herb of many traditional formulae for the treatment of neurodegenerative diseases...
  22. Akesson C, Pero R, Ivars F. C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo. Phytomedicine. 2003;10:23-33 pubmed
    Water extracts of the bark of Uncaria tomentosa, a vine indigenous to South America, has been used for generations as an "immuno modulator"...
  23. Mammone T, Akesson C, Gan D, Giampapa V, Pero R. A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin. Phytother Res. 2006;20:178-83 pubmed
    Cat's Claw (Uncaria tomentosa) water extracts, essentially free of oxindole alkaloids, have been shown to possess a broad spectrum of biological activity including DNA repair enhancement and antiinflammatory properties...
  24. Lin Y, Hsieh C. Oral Uncaria rhynchophylla (UR) reduces kainic acid-induced epileptic seizures and neuronal death accompanied by attenuating glial cell proliferation and S100B proteins in rats. J Ethnopharmacol. 2011;135:313-20 pubmed publisher
    ..Here we aim to determine the protective role of Uncaria rhynchophylla (UR), an herbal drug belong to Traditional Chinese Medicine (TCM), on epileptic rats.
  25. Nishi A, Yamaguchi T, Sekiguchi K, Imamura S, Tabuchi M, Kanno H, et al. Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin ?A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan. Neuroscience. 2012;207:124-36 pubmed publisher
    ..We previously demonstrated that YKS and Uncaria hook (UH), which is a constituent herb of YKS, had a partial agonistic effect to 5-HT(1A) receptors in vitro...
  26. Hou W, Lin R, Chen C, Lee M. Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla. J Ethnopharmacol. 2005;100:216-20 pubmed
    ..The hook of Uncaria rhynchophylla (Miq.) Jacks...
  27. Jung J, Ahn N, Oh H, Lee B, Lee K, Kim S, et al. Anxiolytic effects of the aqueous extract of Uncaria rhynchophylla. J Ethnopharmacol. 2006;108:193-7 pubmed
    ..this study was to characterize the putative anxiolytic-like effects of the aqueous extract of hooks with stem of Uncaria rhynchophylla using the elevated plus maze (EPM) and the hole-board apparatus in rats and mice...
  28. Wang S, Chen Y, He D, He L, Yang Y, Chen J, et al. Inhibition of vascular smooth muscle cell proliferation by serum from rats treated orally with Gastrodia and Uncaria decoction, a traditional Chinese formulation. J Ethnopharmacol. 2007;114:458-62 pubmed
    ..This study was to investigate the effect of serum from rats treated orally with GUD on vascular smooth muscle cells (VSMCs) proliferation in vitro...
  29. Jung T, Pham T, Umeyama A, Shoji N, Hashimoto T, Lee J, et al. Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4+ naïve T cells. Eur J Pharmacol. 2010;643:297-303 pubmed publisher
    Ursolic acid is triterpene isolated from Uncaria rhynchophylla and is a pharmacologically active substance...
  30. Wang J, Liu Z, Long Y, Xin L. [HPLC determination of rhynchophylline and isorhynchophylline in Anshen Yangxue oral liquid]. Zhong Yao Cai. 2009;32:1134-7 pubmed
    ..08 -0.80 microg, there were good linear relationships (r1 = 0.9999, r2 = 0.9993). This method is simple, sensitive, accurate and can be used for the quality control of Anshen Yangxue oral liquid. ..
  31. Shao H, Mi Z, Ji W, Zhang C, Zhang T, Ren S, et al. Rhynchophylline Protects Against the Amyloid β-Induced Increase of Spontaneous Discharges in the Hippocampal CA1 Region of Rats. Neurochem Res. 2015;40:2365-73 pubmed publisher
    ..Rhynchophylline (RIN) is an important active tetracyclic oxindole alkaloid isolated from Uncaria rhynchophylla which is a traditional Chinese medicine and often used to treat central nervous system illnesses ..
  32. Honório I, Bertoni B, Telles M, Braga R, França S, Coppede J, et al. Genetic and chemical diversity of Uncaria tomentosa (Willd. ex. Schult.) DC. in the Brazilian Amazon. PLoS ONE. 2017;12:e0177103 pubmed publisher
    b>Uncaria tomentosa (Willd. ex Schult.) DC., a plant native to the Amazon region, is used widely in popular medicine and by the pharmaceutical industry because of its anti-inflammatory activity...
  33. Zhu W, Zhang Y, Huang Y, Lu L. Chinese Herbal Medicine for the Treatment of Drug Addiction. Int Rev Neurobiol. 2017;135:279-295 pubmed publisher
    ..Rhizoma Corydalis (Yanhusuo) may be used to prevent relapse to chronic drug dependence. Alkaloids of Uncaria rhynchophylla (Gouteng) appear to have positive effects on methamphetamine and ketamine addiction...
  34. Wang D, Wang W, Sun X, Zhao D, Du G. [Effect of tianma gouteng recipe on interfering LV and aortic hypertrophy in renovascular hypertension rats]. Zhongguo Zhong Yao Za Zhi. 2005;30:606-9 pubmed
    ..To investigate the effect of Tianma Gouteng recipe (TGR) on interfering left ventricular (LV) and aortic hypertrophy and tissue angiotensin II (Ang II) in rats with renovascular hypertension...
  35. Li R, Cheng J, Jiao M, Li L, Guo C, Chen S, et al. New phenylpropanoid-substituted flavan-3-ols and flavonols from the leaves of Uncaria rhynchophylla. Fitoterapia. 2017;116:17-23 pubmed publisher
    ..flavonol enantiomers, together with nine known compounds (5-13), were isolated from the leaves of Uncaria rhynchophylla. The structures of 1-4 were established primarily by NMR and HRESIMS experiments...
  36. Li L, Xu L, Chen M, Zhang G, Zhang H, Chen A. Simultaneous separation and determination of four uncaria alkaloids by capillary electrophoresis using dual cyclodextrin system. J Pharm Biomed Anal. 2017;141:39-45 pubmed publisher
    ..a simple, quick and precise capillary zone electrophoresis method (CZE) for the separation and determination of uncaria alkaloids using dual cyclodextrins as additives for the separation...
  37. Sugiyama S. [Recognize uncalia ganbir]. Yakushigaku Zasshi. 2004;39:355-62 pubmed
    The Latin name for Jicha, which is used in bethel chewing, is Uncaria gambir. The plant belongs to the Rubiaceae family, and although its Chinese name is Jicha-Kou-tou, it is more commonly called Katsu-Jicha or Ho-Jicha...
  38. Wang J, Qi P, Hou J, Shen Y, Yang M, Bi Q, et al. The profiling of the metabolites of hirsutine in rat by ultra-high performance liquid chromatography coupled with linear ion trap Orbitrap mass spectrometry: An improved strategy for the systematic screening and identification of metabolites in multi. J Pharm Biomed Anal. 2017;134:149-157 pubmed publisher
    ..Using hirsutine (HTI), an active components of Uncaria rhynchophylla (Gouteng in Chinese) as a model and its plasma, urine, bile, feces and various tissues were ..
  39. Churqui M, Lind L, Thörn K, Svensson A, Savolainen O, Aranda K, et al. Extracts of Equisetum giganteum L and Copaifera reticulate Ducke show strong antiviral activity against the sexually transmitted pathogen herpes simplex virus type 2. J Ethnopharmacol. 2018;210:192-197 pubmed publisher
    ..Arg. and Uncaria tomentosa (Willd. ex Schult.) DC...
  40. Iwasa M, Nakaya S, Maki Y, Marumoto S, Usami A, Miyazawa M. Identification of Aroma-active Compounds in Essential Oil from Uncaria Hook by Gas Chromatography- Mass Spectrometry and Gas Chromatography-Olfactometry. J Oleo Sci. 2015;64:825-33 pubmed publisher
    The chemical composition of essential oil extracted from Uncaria Hook ("Chotoko" in Japanese), the branch with curved hook of the herbal medicine Uncaria rhynchophylla has been investigated by GC and GC-MS analyses...
  41. Kaiser S, Carvalho A, Pittol V, Dietrich F, Manica F, Machado M, et al. Genotoxicity and cytotoxicity of oxindole alkaloids from Uncaria tomentosa (cat's claw): Chemotype relevance. J Ethnopharmacol. 2016;189:90-8 pubmed publisher
    b>Uncaria tomentosa (Willdenow ex Roemer & Schultes) DC. (Rubiaceae) or cat's claw is a climber vine from the South American rainforest used in folk medicine for cancer treatment...
  42. Pan H, Yang W, Yao C, Shen Y, Zhang Y, Shi X, et al. Mass defect filtering-oriented classification and precursor ions list-triggered high-resolution mass spectrometry analysis for the discovery of indole alkaloids from Uncaria sinensis. J Chromatogr A. 2017;1516:102-113 pubmed publisher
    ..mass spectrometry analysis, and to validate it by discovering new indole alkaloids from the medicinal herb Uncaria sinensis. Rapid chromatographic separation was achieved on a Kinetex® EVO C18 column (<16min)...
  43. Garcia R, Cayunao C, Bocic R, Backhouse N, Delporte C, Zaldivar M, et al. Antimicrobial activity of isopteropodine. Z Naturforsch C. 2005;60:385-8 pubmed
    Bioassay-directed fractionation for the determination of antimicrobial activity of Uncaria tomentosa, has led to the isolation of isopteropodine (0...
  44. Zhang Q, Lin C, Duan W, Wang X, Luo A. Preparative separation of six rhynchophylla alkaloids from Uncaria macrophylla wall by pH-zone refining counter-current chromatography. Molecules. 2013;18:15490-500 pubmed publisher
    ..successfully applied to the preparative isolation and purification of six alkaloids from the ethanol extracts of Uncaria macrophylla Wall. Because of the low content of alkaloids (about 0.2%, w/w) in U...
  45. Moura M, Lopes L, Biavatti M, Busse J, Wang L, Kennedy S, et al. Brazilian oral herbal medication for osteoarthritis: a systematic review protocol. Syst Rev. 2016;5:86 pubmed publisher
    ..prospero 42015019793. ..
  46. Ueki T, Nishi A, Imamura S, Kanno H, Mizoguchi K, Sekiguchi K, et al. Effects of geissoschizine methyl ether, an indole alkaloid in Uncaria hook, a constituent of yokukansan, on human recombinant serotonin 7 receptor. Cell Mol Neurobiol. 2013;33:129-35 pubmed publisher
    ..methyl ether (GM), hirsutine, hirsuteine, rhynchophylline, isorhynchophylline, corynoxeine and isocorynoxeine, in Uncaria hook, a constituent of the kampo medicine yokukansan, on serotonin(7) (5-HT(7)) receptor were investigated using ..
  47. Shao H, Yang Y, Mi Z, Zhu G, Qi A, Ji W, et al. Anticonvulsant effect of Rhynchophylline involved in the inhibition of persistent sodium current and NMDA receptor current in the pilocarpine rat model of temporal lobe epilepsy. Neuroscience. 2016;337:355-369 pubmed publisher
    Rhynchophylline (RIN) is a significant active component isolated from the Chinese herbal medicine Uncaria rhynchophylla...
  48. Zhao B, Huang Y, Chen Q, Chen Q, Miao H, Zhu S, et al. Characteristic component profiling and identification of different Uncaria species based on high-performance liquid chromatography-photodiode array detection tandem ion trap and time of flight mass spectrometry coupled with rDNA ITS sequence. Biomed Chromatogr. 2017;: pubmed publisher
    b>Uncaria is a multi-source herb and its species identification has become a bottleneck in quality control...
  49. Lin R, Hou W, Yen K, Lee M. Inhibition of monoamine oxidase B (MAO-B) by Chinese herbal medicines. Phytomedicine. 2003;10:650-6 pubmed
    ..colchesteri, Lycium chinense, and Uncaria rhynchophylla, exhibited the best activity and selectivity towards MAO-B with IC50 values of 0.44, 0.29, 0...
  50. Meng Q, Pang Q, Ma J, Zhang H, Zhao J. [Transmission spectral imaging research on folium uncariae from Guangdong]. Zhong Yao Cai. 2010;33:696-9 pubmed
    ..Spectral imaging analysis techniques can be used to construct fingerprints of traditioanal Chinese medicine, quality evaluation and study of plant phylogenetic relationships, etc., the operation method is simple, rapid. ..
  51. Xie S, Shi Y, Wang Y, Wu C, Liu W, Feng F, et al. Systematic identification and quantification of tetracyclic monoterpenoid oxindole alkaloids in Uncaria rhynchophylla and their fragmentations in Q-TOF-MS spectra. J Pharm Biomed Anal. 2013;81-82:56-64 pubmed publisher
    b>Uncaria rhynchophylla (UR) is a species of Uncaria that is distributed mainly in China and Japan...
  52. Zhang L, Koyyalamudi S, Jeong S, Reddy N, Bailey T, Longvah T. Immunomodulatory activities of polysaccharides isolated from Taxillus chinensis and Uncaria rhyncophylla. Carbohydr Polym. 2013;98:1458-65 pubmed publisher
    Taxillus chinensis and Uncaria rhyncophylla are the herbs used in traditional Chinese anticancer formulations...
  53. Sazwi N, Nalina T, Abdul Rahim Z. Antioxidant and cytoprotective activities of Piper betle, Areca catechu, Uncaria gambir and betel quid with and without calcium hydroxide. BMC Complement Altern Med. 2013;13:351 pubmed publisher
    ..682). The betel quid has higher TPC, and antioxidant and cytoprotective activities than betel quid with calcium hydroxide. The quinic acid in betel quid may play an important role in the oral health protection. ..
  54. Wei B, Yang Z, Chen X, Zhou S, Yu H, Sun J, et al. Colletotrilactam A-D, novel lactams from Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla. Fitoterapia. 2016;113:158-63 pubmed publisher
    ..5-10) were isolated from the culture broth of Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla. The structures of these compounds were elucidated by comprehensive NMR spectroscopy...
  55. Wang X, Qiao Z, Liu J, Zheng M, Liu W, Wu C. Stereoselective in vitro metabolism of rhynchophylline and isorhynchophylline epimers of Uncaria rhynchophylla in rat liver microsomes. Xenobiotica. 2017;:1-9 pubmed publisher
    ..5.?In conclusion, data revealed that due to the spatial configurations at C-7 position, RIN and IRN epimers possessed different hepatic metabolic pathways and elimination rates which were mainly mediated by CYP3A...
  56. de Fatima Fernandes Vattimo M, da Silva N. [Uncaria tomentosa and acute ischemic kidney injury in rats]. Rev Esc Enferm USP. 2011;45:194-8 pubmed
    The objective of this study was to evaluate the renoprotective effects of Uncaria Tomentosa (cat's claw) on ischemic acute kidney injury induced by renal clamping in rats...
  57. Kośmider A, Czepielewska E, Kuraś M, Gulewicz K, Pietrzak W, Nowak R, et al. Uncaria tomentosa Leaves Decoction Modulates Differently ROS Production in Cancer and Normal Cells, and Effects Cisplatin Cytotoxicity. Molecules. 2017;22: pubmed publisher
    i>Uncaria tomentosa is a woody vine with a long history of use in traditional Peruvian medicine and nowadays supplements containing this vine as ingredient are available...
  58. Wu T, Chen C, Chen C, Jinn T. Traditional Chinese medicines and Alzheimer's disease. Taiwan J Obstet Gynecol. 2011;50:131-5 pubmed publisher
    ..the latest research progress on six herbs for AD therapy-Huperzia serrata, Amaryllidaceae family, Ginkgo biloba, Uncaria rhynchophylla, Polygala tenuifolia, and Salvia officinalis-and focus on the analysis of their active components ..
  59. Pan H, Yang W, Zhao D, Luo C, Yao C, Shi X, et al. New monoterpenoid oxindole alkaloid derivatives from the stems of Uncaria hirsuta Havil. and their cytotoxicity and tandem mass spectrometric fragmentation. Fitoterapia. 2017;116:85-92 pubmed publisher
    ..B N-oxide, 4), together with four known heteroyohimbine-type oxindole alkaloids, were isolated from the stems of Uncaria hirsuta Havil. Structures of 1-4 were elucidated by extensive NMR and HR-ESIMS data analyses...
  60. Wu J, Li G, Wang D. [Chemical constituents of the non-alkaloid fraction of Uncaria macrophylla]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27:226-7 pubmed
    To analyze the chemical constituents of the non-alkaloid fraction of Uncaria macrophylla...
  61. Zeng K, Thompson K, Yates C, Miller D. Synthesis and biological evaluation of quinic acid derivatives as anti-inflammatory agents. Bioorg Med Chem Lett. 2009;19:5458-60 pubmed publisher
    Quinic acid (QA) esters found in hot water extracts of Uncaria tomentosa (a.k.a...
  62. Nudo L, Catap E. Immunostimulatory effects of Uncaria perrottetii (A. Rich.) Merr. (Rubiaceae) vinebark aqueous extract in Balb/C mice. J Ethnopharmacol. 2011;133:613-20 pubmed publisher
    Crude extract of Uncaria perrottetii (A. Rich.) Merr. vinebark was evaluated for its immunomodulating activity in Balb/C mice...
  63. Kanno H, Kawakami Z, Iizuka S, Tabuchi M, Mizoguchi K, Ikarashi Y, et al. Glycyrrhiza and Uncaria Hook contribute to protective effect of traditional Japanese medicine yokukansan against amyloid ? oligomer-induced neuronal death. J Ethnopharmacol. 2013;149:360-70 pubmed publisher
    ..Among the seven constituents of yokukansan, Glycyrrhiza and Uncaria Hook (60-200 µg/mL) suppressed A? oligomer-induced neuronal damage, DNA fragmentation, karyopyknosis, and ..
  64. Yang W, Zhang Y, Pan H, Yao C, Hou J, Yao S, et al. Supercritical fluid chromatography for separation and preparation of tautomeric 7-epimeric spiro oxindole alkaloids from Uncaria macrophylla. J Pharm Biomed Anal. 2017;134:352-360 pubmed publisher
    ..Spiro oxindole alkaloids (SOAs), as the markers for the medicinal Uncaria herbs, can easily isomerize in polar or aqueous solvent via a retro-Mannich reaction...
  65. Kang T, Murakami Y, Takayama H, Kitajima M, Aimi N, Watanabe H, et al. Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action. Life Sci. 2004;76:331-43 pubmed
  66. Gewartowska M, Olszewski W. The new approaches to preservation of graft cell integrity in preservation for transplantation. Ann Transplant. 2005;10:6-10 pubmed
    ..We review the new experimentally studied cytoprotective substances and their application in cell membrane protection. Moreover, we present our data on the effects of hyperosmolarity and its protective effect on cell internal structure. ..
  67. Mistrangelo M, Cornaglia S, Pizzio M, Rimonda R, Gavello G, Dal Conte I, et al. Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial. Colorectal Dis. 2010;12:799-803 pubmed publisher
    ..Human papillomavirus is the most common cause of sexually transmitted disease. It is associated with immunosuppression and shows a marked tendency to recur. We investigated a natural immunostimulant aimed to reduce recurrence...
  68. Zhou J, Mo Z, Zhou S. Effect of rhynchophylline on central neurotransmitter levels in amphetamine-induced conditioned place preference rat brain. Fitoterapia. 2010;81:844-8 pubmed publisher
    ..These findings show that rhynchophylline reverses the expression of amphetamine-induced rewarding effect which is partly mediated by regulation of central neurotransmitter levels in the rat brain. ..
  69. Zhang J, Geng C, Huang X, Chen X, Ma Y, Zhang X, et al. Chemical and biological comparison of different sections of Uncaria rhynchophylla (Gou-Teng). Eur J Mass Spectrom (Chichester). 2017;23:11-21 pubmed publisher
    b>Uncaria rhynchophylla (Gou-Teng in Chinese) is officially documented in Chinese pharmacopoeia as one of the authentic sources for the crude drug of Gou-Teng which has long been used for mental and cardiovascular diseases...
  70. Ciani F, Tafuri S, Troiano A, Cimmino A, Fioretto B, Guarino A, et al. Anti-proliferative and pro-apoptotic effects of Uncaria tomentosa aqueous extract in squamous carcinoma cells. J Ethnopharmacol. 2018;211:285-294 pubmed publisher
    b>Uncaria tomentosa (Willd.) DC. (Rubiacee), also known as uña de gato, is a plant that grows wild in the upper Amazon region of Peru and has been widely used in folk medicine to treat several health conditions including cancer...
  71. Sun X, Wang W, Wang D, Zhao D, Du G. [Effects of Tianzhi Keli on extracellular acetylcholine and catecholamine levels in striatum of rats with neuromitochondrial impairment]. Zhongguo Zhong Yao Za Zhi. 2005;30:141-5 pubmed
    ..TZ also has tendency to protect the impairment of epinephrine and dopamine neurosystem. ..
  72. Pero R, Amiri A, Sheng Y, Welther M, Rich M. Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements. Phytomedicine. 2005;12:255-63 pubmed
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    ..Optimize the technic condition of Duzhong Jiangya prescription with Semi-bionic Extraction...
  74. Wang W, Ma C, Hattori M. Metabolism of isorhynchophylline in rats detected by LC-MS. J Pharm Pharm Sci. 2010;13:27-37 pubmed
    ..ISOR was involved in the circulatory system after oral administration. Cytochrome P450 (CYP) in rat liver microsomes played a key role in ISOR hydroxylation. ..
  75. Almeida I, Soares L, Lucio F, Cantagalli L, Reusing A, Vicentini V. Chemotherapeutical effects of the herbal medicine Uncaria tomentosa (Willd.) DC. Genet Mol Res. 2017;16: pubmed publisher
    ..The medicinal plant named Uncaria tomentosa (Willd.) DC...
  76. Akesson C, Lindgren H, Pero R, Leanderson T, Ivars F. Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100. Int Immunopharmacol. 2005;5:219-29 pubmed
    We have previously reported that the C-Med 100 extract of the plant Uncaria tomentosa induces prolonged lymphocyte half life and hence increased spleen cell number in mice receiving the extract in their drinking water...
  77. Förster T, López Tosco S, Ziegler S, Antonchick A, Waldmann H. Enantioselective Organocatalytic Synthesis of a Secoyohimbane-Inspired Compound Collection with Neuritogenic Activity. Chembiochem. 2017;18:1098-1108 pubmed publisher
    ..Rhynchophylline is the major component of Uncaria species, and has been used to treat neurological diseases in Chinese traditional medicine...
  78. Laus G. Advances in chemistry and bioactivity of the genus Uncaria. Phytother Res. 2004;18:259-74 pubmed
    The alkaloids of the pantropical genus Uncaria (Rubiaceae) were reviewed extensively by Phillipson et al. in (1978) Since then a host of papers with new results has been published...
  79. Yokoyama K, Shimada Y, Hori E, Nakagawa T, Takagi S, Sekiya N, et al. Effects of Choto-san and hooks and stems of Uncaria sinensis on antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia. J Ethnopharmacol. 2004;95:335-43 pubmed
    Previously, we revealed that oral administrations of Choto-san, a Kampo formula, and the hooks and stems of Uncaria sinensis Haviland (Rubiaceae), a medicinal plant comprising Choto-san, enhanced superoxide anion and hydroxyl radical ..
  80. Hu X, Sun A, Sui Y. [Effects of combined use of total alkaloids of Uncaria rhynchophylla and Coryadlis ambailis migo on cerebral ischemia-reperfusion injury in rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27:1007-9 pubmed
    To study the effects of combined use of total alkaloids (TA) of Uncaria rhynchophylla (UR) and Coryadlis ambailis migo (CAM) on cerebral ischemia/reperfusion injury in rats.
  81. Matsuo H, Okamoto R, Zaima K, Hirasawa Y, Ismail I, Lajis N, et al. New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. Bioorg Med Chem. 2011;19:4075-9 pubmed publisher
    Villocarines A-D (1-4), four new indole alkaloids have been isolated from the leaves of Uncaria villosa (Rubiaceae) and their structures were elucidated by 2D NMR methods and chemical correlations...
  82. Yang X, Hong Y, Wu F, Ruan K, Feng Y. [Determination of rhynchophylline and isorhynchophylline in Uncaria rhynchophylla by HPLC]. Zhongguo Zhong Yao Za Zhi. 2013;38:720-4 pubmed
    To explore an HPLC method for determination of rhnchophylline and isorhnchophylline in Uncaria rhnchophylla.
  83. Zhang M, Liu B, Liao S, Xu Y, Feng D, Ji K, et al. Uncarilic acid and secouncarilic acid, two new triterpenoids from Uucaria sessilifructus. Molecules. 2013;18:9727-34 pubmed publisher
    ..A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated. ..
  84. Yuzurihara M, Ikarashi Y, Goto K, Sakakibara I, Hayakawa T, Sasaki H. Geissoschizine methyl ether, an indole alkaloid extracted from Uncariae Ramulus et Uncus, is a potent vasorelaxant of isolated rat aorta. Eur J Pharmacol. 2002;444:183-9 pubmed
  85. Sun G, Zhang X, Xu X, Yang J, Zhong M, Yuan J. A new triterpene From Uncaria macrophylla and its antitumor activity. Molecules. 2012;17:1883-9 pubmed publisher
    ..acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla...
  86. Ndagijimana A, Wang X, Pan G, Zhang F, Feng H, Olaleye O. A review on indole alkaloids isolated from Uncaria rhynchophylla and their pharmacological studies. Fitoterapia. 2013;86:35-47 pubmed publisher
    b>Uncaria rhynchophylla (Miq.) Jacks, Rubiaceae, is one of the original plants of the important Chinese crude drug, Gou-teng, mainly used for the treatment of convulsion, hypertension, epilepsy, eclampsia, and cerebral diseases...
  87. Antonchick A, López Tosco S, Parga J, Sievers S, Schürmann M, Preut H, et al. Highly enantioselective catalytic synthesis of neurite growth-promoting secoyohimbanes. Chem Biol. 2013;20:500-9 pubmed publisher
    ..The spirocyclic secoyohimbane alkaloid rhynchophylline is the major component of the extracts of Uncaria species used in Chinese traditional medicine for treatment of disorders of the central nervous system...
  88. Murakami Y, Zhao Q, Harada K, Tohda M, Watanabe H, Matsumoto K. Choto-san, a Kampo formula, improves chronic cerebral hypoperfusion-induced spatial learning deficit via stimulation of muscarinic M1 receptor. Pharmacol Biochem Behav. 2005;81:616-25 pubmed
    ..Choto-san and Uncaria, a major constituent of Choto-san, caused an improvement in 2VO-induced learning deficits, whereas Uncaria-free ..
  89. Choi D, Huh J, Lee J, Cho E, Baek Y, Yang H, et al. Uncaria rhynchophylla induces angiogenesis in vitro and in vivo. Biol Pharm Bull. 2005;28:2248-52 pubmed
    ..The aim of this study was to determine the angiogenic properties of Uncaria rhynchophylla...
  90. Chen X, Zhang H, Shao S, Liang Z, Mo Z. [Pharmacognostical identification of the leaf of Uncaria hirsuta Havil]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:269-71 pubmed
    To perform a pharmacognostical study of the leaf of Uncaria hirsuta Havil.
  91. Jiang H, Nie L, Li Y, Xie J. Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription. J Sep Sci. 2012;35:483-9 pubmed publisher
    ..This study suggests that the metabonomic method may be a valuable and feasible tool to explore the therapeutic effect and mechanism of traditional Chinese medicine (TCM)...
  92. Hu Y, Huo K, Xiang H. [Policy recommendations based on SWOT analysis for agricultural industrialization of traditional Chinese medicinal materials--a case study of uncariae ramulus cum uncis from Jianhe county in Guizhou province]. Zhongguo Zhong Yao Za Zhi. 2013;38:2894-7 pubmed
    ..It also utilizes SWOT analysis method to discuss the industrialization of traditional Chinese medicinal materials in Jianhe county, and finally it puts forward the recommendations for its further development...